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In the United States, endometrial cancer is the most frequently diagnosed gynecologic cancer and, in women, the fourth most common cancer overall, representing 6% of all cancer cases in women. In that country, it was estimated that 52,630 women were diagnosed yearly and 8,590 would die from the disease. Northern Europe, Eastern Europe, and North America have the highest rates of endometrial cancer, whereas Africa and West Asia have the lowest rates. Asia saw 41% of the world's endometrial cancer diagnoses in 2012, whereas Northern Europe, Eastern Europe, and North America together comprised 48% of diagnoses. Unlike most cancers, the number of new cases has risen in recent years, including an increase of over 40% in the United Kingdom between 1993 and 2013. Some of this rise may be due to the increase in obesity rates in developed countries, increasing life expectancies, and lower birth rates. The average lifetime risk for endometrial cancer is approximately 2–3% in people with uteruses. In the UK, approximately 7,400 cases are diagnosed annually, and in the EU, approximately 88,000.
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https://en.wikipedia.org/wiki?curid=412809
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"The Guardian" and "The New York Times" have reported in 2013 that the National Security Agency (NSA) inserted a backdoor into a pseudorandom number generator (PRNG) of NIST SP 800-90A which allows the NSA to readily decrypt material that was encrypted with the aid of Dual_EC_DRBG. Both papers report that, as independent security experts long suspected, the NSA has been introducing weaknesses into CSPRNG standard 800-90; this being confirmed for the first time by one of the top secret documents leaked to the Guardian by Edward Snowden. The NSA worked covertly to get its own version of the NIST draft security standard approved for worldwide use in 2006. The leaked document states that "eventually, NSA became the sole editor." In spite of the known potential for a kleptographic backdoor and other known significant deficiencies with Dual_EC_DRBG, several companies such as RSA Security continued using Dual_EC_DRBG until the backdoor was confirmed in 2013. RSA Security received a $10 million payment from the NSA to do so.
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https://en.wikipedia.org/wiki?curid=182249
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Rather than testing a student's content knowledge, the ITED endeavors to evaluate students' skills in a variety of areas, especially based on problem solving and critical analysis of texts. These are considered by the authors of the ITED to be skills acquired across multiple curricular areas and skills that are important for academic success. Within the skill areas evaluated by the ITED, the test is designed to elicit information about a student's current skill level, growth and abilities within each area tested. The ITED is designed to examine and compare a student's ability in several educational fields, including vocabulary, reading comprehension, language, spelling, mathematical concepts and problem solving, computation, analysis of social studies materials, analysis of science materials, and use of sources. Although the test is broken up into these fields, the goal of the ITED is to track the development of the skills and analysis needed in each of these areas rather than the content.
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https://en.wikipedia.org/wiki?curid=3331807
| 1,880,581
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Microarrays was once the mainstay of the transcriptomics the last ten years and array based technology has subsequently branched out to other areas. However, they are limited in that only information can be obtained for probes that are on the chip. Only information for organisms for which chips are available can obtained, and they come with all the problems of hybridizing large numbers of molecules (differing hybridizing temperatures). RNA-Seq transcriptomics by next gen sequencing will mean these barriers no longer hold true. Any organism's entire transcriptome could be potentially sequenced in one run (for very small bacterial genomes) and not only would the identification of each transcript be available but expression profiling is possible as quantitative reads can also be achieved.
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https://en.wikipedia.org/wiki?curid=15236363
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One recurring problem in ACL rehabilitation is improving muscle strength of the quadriceps without re-injury. Early, high-force eccentric training can be used to increase muscle strength and volume without damage to the ACL graft, surrounding soft-tissue, and the articular cartilage. In an experiment performed on rat muscles after twenty sessions of treadmill low intensity eccentric training the wet weight of the muscles and the fiber cross-section were significantly larger than the control and level groups. These results led to the conclusion that low intensity eccentric contractions have the ability to "produce enough mechanical stress to induce muscle hypertrophy without over-stressing which could produce muscle fiber damage. Other articles have found that muscle damage is not required to reach hypertrophy. Greater mechanical stress brought on by eccentric contractions is what leads to hypertrophy in individuals undergoing eccentric training. Studies done on the elderly show that low-intensity eccentric conditioning can actually minimize muscle damage According to Gault the low cost of energy, and low oxygen demand make low-intensity eccentric exercise ideal for the elderly.
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https://en.wikipedia.org/wiki?curid=29763544
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Maciej Lewenstein was born on 21.09.1955. He graduated at the Institute for Theoretical Physics at Warsaw University in 1978, with his diploma thesis about the superradiance phenomenon written under the supervision of Prof. . After one year of working as a scientific assistant at the ITP of Warsaw University, he joined in 1979 the new Centre for Theoretical Physics of the Polish Academy of Sciences in Warsaw (CFT), newly formed by Prof. I. Białynicki-Birula. At CFT he started his PhD studies on applications of functional integration methods in quantum optics with Prof. K. Rzążewski. In 1981 he became a DAAD stipend holder at the Essen University. There, he completed his thesis under the joint supervision of Prof. F. Haake in 1983 with summa cum laude and the Prize of the University. In the years 1984-1986 he spent long term visits as a postdoc at Essen University with Prof. F. Haake working on statistical physics of disordered systems. After returning to Poland and becoming a faculty member of the CFT, he habilitated in 1986 at the Institute of Physics in Warsaw. Lewenstein's habilitation concerned cavity quantum electrodynamics and intense laser-matter interactions.
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https://en.wikipedia.org/wiki?curid=46396821
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1,139,891
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Pentax lenses were first badged as Takumar. The Takumar branded lenses were well respected for their line of Super Takumar, which designated the high performance coating applied to the lens as well as the optical formulas used to make them. The majority of the industry at the time was still satisfied with the variations of the "plumb" coating process and later some of the two and three layer processes as well. Asahi Pentax soon introduced the Takumar Super-Multi-Coated line of lenses which was a 7 layer process as the industry had just caught up with similar forms of 5 layer multi-coated optics. Eventually Asahi Optical and Pentax slowly shifted much of their lens production under the Pentax name and transitioned some of the successful designs that were first introduced under the Takumar name to use Asahi/Pentax badging as well as beginning to use the "smc" abbreviation. Eventually the Asahi partnership disappeared and the Pentax name became solely used. Pentax lenses saw many feature changes to answer the market, such as: incorporating "Auto-Aperture" with the M42, the light weight and compactness with the 'M' series, Aperture Priority overrides with the 'A' series, and Auto-Focus with the 'F' series. Modern Pentax lenses for digital SLR cameras have seen the elimination of the aperture ring completely as found on Pentax DA and D-FA series lenses. They use the Pentax K mount (and its variants, K, K and K). All of these lenses have an autofocus feature, either operated from the camera body or from an internal SDM motor. Pentax compatible lenses are also made by third-party companies.
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https://en.wikipedia.org/wiki?curid=20340164
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One mark of a good author is the ability to make a successful book out of an unpromising subject. Over the years, Donald E. Knuth has produced a slew of bestsellers on topics that might seem to have only limited appeal, most notably the arts of computer programming and mathematical typography. His latest book takes on a subject so challenging it has to hide behind a coy title: Things a Computer Scientist Rarely Talks About (CSLI Publications, $35). What is this subject that dare not speak its name? Not sex, but religion. The book is based on a series of lectures on "interactions between faith and computer science." The main topic is Knuth's approach to Bible study through random sampling (which led to an earlier book as well, titled 3:16); there is also musing on the programmer's role as god of a created universe. It's a very unpromising subject, but Knuth is a very good author.
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https://en.wikipedia.org/wiki?curid=17394241
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The John D. Odegard School of Aerospace Sciences (UND Aerospace) is a multidisciplinary college within the University of North Dakota (UND) in Grand Forks, North Dakota. The school was formed in 1968. The majority of the school's fleet of over 120 aircraft is based at nearby Grand Forks International Airport and is the largest fleet of civilian flight training aircraft in North America. UND Aerospace also operates a flight training center at Phoenix–Mesa Gateway Airport in Mesa, Arizona. Today, the school has many aerospace-related programs including commercial aviation (fixed wing and rotorcraft), Unmanned aircraft systems operations, air traffic control, airport management, Space Studies, Computer Science, Atmospheric Sciences, and Earth System Science & Policy. Currently, the school has over 500 faculty and 2,000 students making it the second largest of UND's degree-granting colleges. The present dean of the school is Robert Kraus.
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https://en.wikipedia.org/wiki?curid=6408751
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Most of the gas generated during heating of the heat-transfer oil does not come into contact the waste material and can be discharged directly to the atmosphere without emission controls. The remainder of the flue gas maintains the thermal screw purge gas exit temperature above 300 degrees F. This ensures that volatilized organics and moisture do not condense. In addition, the recycled flue gas has a low oxygen content (less than 2% by volume) which minimizes oxidation of the organics and reduces the explosion hazard. If pretreatment analytical data indicates a high organic content (greater than 4 percent), use of a thermal screw is recommended. After the treated soil exits the thermal screw, water is sprayed on the soil for cooling and dust control. Thermal screws are available with soil treatment capacities ranging from 3-15 tons per hour.
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https://en.wikipedia.org/wiki?curid=8851414
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Planar cell polarity was first described in insects and then further defined in fruit flies ("Drosophila melanogaster"). Some of the earlier work on gene controlled polarity of fly wings was published by D. Gubb and A. García-Bellido in 1982 describing how the mutation of some genes resulted in a morphology change in the cuticle orientation on the fly body. The history of the PCP pathway as it was expanded by fly genetics work, which lead to the interesting names for PCP components like "Frizzled", "Van-gogh", and "Dishevelled". These are typical nomenclature for new genes discovered in flies, which are often based on the description of the visual presentation of the mutant flies for each gene. Early PCP research focused on its role in embryology and genetics, but the discovery that PCP proteins were localized asymmetrically within the cell pushed the topic into the world of cell biology.
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https://en.wikipedia.org/wiki?curid=15592325
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The problem of counting planar perfect matchings has its roots in statistical mechanics and chemistry, where the original question was: If diatomic molecules are adsorbed on a surface, forming a single layer, how many ways can they be arranged? The partition function is an important quantity that encodes the statistical properties of a system at equilibrium and can be used to answer the previous question. However, trying to compute the partition function from its definition is not practical. Thus to exactly solve a physical system is to find an alternate form of the partition function for that particular physical system that is sufficiently simple to calculate exactly. In the early 1960s, the definition of "exactly solvable" was not rigorous. Computer science provided a rigorous definition with the introduction of polynomial time, which dates to 1965. Similarly, the notation of not "exactly solvable", for a counting problem such as this one, should correspond to #P-hardness, which was defined in 1979.
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https://en.wikipedia.org/wiki?curid=30159370
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MRSECs form a significant component of NSF's center-based research portfolio, but are also of historical importance. MRSECs were established by NSF in 1994 but have their roots in the NSF Materials Research Laboratories (MRLs) started in 1972, which in turn evolved from the Interdisciplinary Laboratories (IDLs) initiated by the Department of Defense in 1960. These cross-disciplinary, center-based activities required significant changes in how materials research and education were carried out at academic institutions and the IDLs/MRLs are credited with contributing to the accelerating growth of Materials Science and Engineering Departments in the U.S. in the 1960s to 1980s. They also made significant contributions to the National Materials Program that emerged from the early post Sputnik era, leading to a vigorous growth in science and engineering graduate education and the development of university based experimental facilities.
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https://en.wikipedia.org/wiki?curid=30862721
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The fire lance () was a gunpowder weapon and the ancestor of modern firearms. It first appeared in 10th–12th century China and was used to great effect during the Jin-Song Wars. It began as a small pyrotechnic device attached to a polearm weapon, used to gain a shock advantage at the start of a melee. As gunpowder improved, the explosive discharge was increased, and debris or pellets added, giving it some of the effects of a combination modern flamethrower and shotgun, but with a very short range (about ), and only one shot (some were designed for two shots). By the late 13th century, fire lance barrels had transitioned to metal material to better withstand the explosive blast, and the lance-point was discarded in favor of relying solely on the gunpowder blast. These became the first hand cannons.
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https://en.wikipedia.org/wiki?curid=5318699
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After the initial loop, the sequences follows to the first and longest β-sheet (sI). A second loop precedes large "amphipathic α-helix" (hA) that longitudinally spans protein site. The β-strands sII and sIII follows separated by the respective loops, loop 4 being commonly designated as "short loop" bridging sII to sIII. Following the sIII strand the sequence meets the 'S-shaped double loop' that is of primary importance for the peptide structure and catalytic activity (see further) as it extends to the cleft side "bulge", continuing to the only antiparallel β-strand sIV, which is prime importance for binding peptidic substrates or inhibitors by forming main chain hydrogen bond. Following sIV, loop Gln186-Gly192 and β-strand sV are responsible for contributing with many ligands to the several metal ions present in the protein (read further). A large open loop follows sV which has proven importance in substrate specificity within the MMPs family. A specific region (183)RWTNNFREY(191) has been identified as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity. On C-terminal part of the CAT Domain the hB α-helix, known as the "active-site helix" encompasses part of the "zinc-binding consensus sequence" HEXXHXXGXXH that is characteristic of the Metzincin superfamily. The α-helix hB finishes abruptly at Gly225 where the last loop of the domain starts. This last loop contains the "specificity loop" which is the shortest in the MMPs family. The Catalytic Domain ends at Gly261 with α-helix hC.
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https://en.wikipedia.org/wiki?curid=14027081
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Passive mass shielding of four metric tons per square meter of surface area will reduce radiation dosage to several mSv or less annually, well below the rate of some populated high natural background areas on Earth. This can be leftover material (slag) from processing lunar soil and asteroids into oxygen, metals, and other useful materials. However, it represents a significant obstacle to manoeuvring vessels with such massive bulk (mobile spacecraft being particularly likely to use less massive active shielding). Inertia would necessitate powerful thrusters to start or stop rotation, or electric motors to spin two massive portions of a vessel in opposite senses. Shielding material can be stationary around a rotating interior.
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https://en.wikipedia.org/wiki?curid=29248
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Later that year he was assigned to the Manhattan Project, and moved with his family to Los Alamos, New Mexico. There he joined the Los Alamos Laboratory's Ordnance (O) Division, which was under the command of another Naval officer, Captain William S. Parsons. Initially the goal of the O Division was to design a gun-type nuclear weapon known as Thin Man. This proved to be impractical due to contamination of the reactor-bred plutonium with plutonium-240, and in February 1944, the Division switched its attention to the development of the Little Boy, a smaller device using uranium-235. Birch used unenriched uranium to create scale models and later full-scale mock-ups of the device.
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https://en.wikipedia.org/wiki?curid=14105833
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Population-based studies in Europe and North America have identified a consistent prevalence of approximately 0.1% of children having a hearing loss of more than 40 decibels through review of health or education records, or both. Other international studies using different methods or criteria have reported higher estimates. In the United States, studies have shown a wide range of estimates for the number of children with hearing loss depending upon the reported age range, type, degree, frequency, laterality and method of ascertainment (e.g. audiometric testing, parental report, record review). Audiometric data of adolescents aged 12 to 19 years obtained through the National Health and Nutrition Examination Survey (NHANES) identified 3% to 5% of adolescents with hearing loss of 25 decibels or more and 15% to 20% with hearing losses of greater than 15 decibels.
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https://en.wikipedia.org/wiki?curid=32101377
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“The initial force of a composition is the invention of some definite theme, and not the desire to describe a given emotion by musical means. Thanks to that primitive and mysterious power, whose mode of action will forever be hidden from us, a theme, a melody flashes on the composer’s mind. The origin of this first germ cannot be explained, but must simply be accepted as a fact. When once it has taken root in the composer’s imagination, it forthwith begins to grow and develop; the principal theme being the center round which the branches group themselves in all conceivable ways, though always unmistakably related to it. The beauty of an independent and simple theme appeals to our aesthetic feeling with that directness, which tolerates no explanation, except, perhaps, that of its inherent fitness and the harmony of parts, to the exclusion of any alien factor. It pleases for its own sake, like an arabesque, a column, or some spontaneous product of nature – a leaf or a flower.”
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https://en.wikipedia.org/wiki?curid=364624
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As a black project (i.e. one that was secret and publicly unacknowledged), but one that was impossible to completely conceal, MOL needed some "white" (i.e. unclassified and publicly acknowledged) experiments as cover. An MOL Experiments Working Group was created under Colonel William Brady. Some 400 experiments proposed by several agencies were examined. These were consolidated and reduced to 59, and twelve primary and eighteen secondary ones were selected. A 499-page report on the experiments was issued on 1 April 1964. Although reconnaissance was its main purpose, "manned orbiting laboratory" was still an accurate description; the program hoped to prove that astronauts could perform militarily useful tasks in a shirt-sleeve environment in space for up to thirty days.
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https://en.wikipedia.org/wiki?curid=615373
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"Montrose" deployed in 2006 to the Persian Gulf on Operation Telic in the first half of 2006. After returning to the UK for personnel changes and maintenance, from 8 January to 27 July 2007, "Montrose" then deployed for seven months to the Mediterranean Sea as the UK contribution to the Standing NATO Maritime Group Two (SNMG2). As part of this group, she participated in NATO's Operation Active Endeavour (OAE), countering terrorist activity in the Mediterranean and preventing smuggling and other illegal activity. After Summer Leave, the ship headed to Scotland to take part in Exercise Neptune Warrior, and was visited there by Prince Michael of Kent, Honorary Rear Admiral of the Royal Naval Reserve, on 24 September 2007.
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https://en.wikipedia.org/wiki?curid=449988
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Diagnosis of BSE continues to be a practical problem. It has an incubation period of months to years, during which no signs are noticed, though the pathway of converting the normal brain prion protein (PrP) into the toxic, disease-related PrP form has started. At present, no way is known to detect PrP reliably except by examining "post mortem" brain tissue using neuropathological and immunohistochemical methods. Accumulation of the abnormally folded PrP form of PrP is a characteristic of the disease, but it is present at very low levels in easily accessible body fluids such as blood or urine. Researchers have tried to develop methods to measure PrP, but no methods for use in materials such as blood have been accepted fully.
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https://en.wikipedia.org/wiki?curid=19344418
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"H. naledi" anatomy indicates that, though they were capable of long-distance travel with a humanlike stride and gait, they were more arboreal than other "Homo", better adapted to climbing and suspensory behaviour in trees than endurance running. Tooth anatomy suggests consumption of gritty foods covered in particulates such as dust or dirt. Though they have not been associated with stone tools or any indication of material culture, they appear to have been dextrous enough to produce and handle tools, and likely manufactured Early or Middle Stone Age industries. It has also been controversially postulated that these individuals were given funerary rites, and were carried into and placed in the chamber. In December 2022, suggestions that "H. naledi" used fire for light and cooking were reported.
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https://en.wikipedia.org/wiki?curid=47774240
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Built in 1892 to serve as a laboratory for City Hospital, it was "the first institution in the nation for pathological and bacteriological research". The project was funded by the Strecker family. The building was designed by architects Frederick Clarke Withers and Walter Dickson in the Romanesque Revival style with large arched windows to provide plenty of natural lighting and ventilation. On the first floor were an autopsy room and an office, while the floor above housed laboratories where specimens were examined. The cellar was used as a mortuary and for storage. Administrative support was provided by the nearby City Hospital. An additional storey was later built, providing room for the examination of histological samples, a scientific library and a pathology museum.
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https://en.wikipedia.org/wiki?curid=25026073
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The secondary structure of group II introns is characterized by six typical stem-loop structures, also called domains I to VI (DI to DVI, or D1 to D6). The domains radiate from a central core that brings the 5' and 3' splice junctions into close proximity. The proximal helix structures of the six domains are connected by a few nucleotides in the central region (linker or joiner sequences). Due to its enormous size, the domain I was divided further into subdomains a, b, c, and d. Sequence differences of group II introns that led to a further division into subgroups IIA, IIB and IIC were identified, along with varying distance of the bulged adenosine in domain VI (the prospective branch point forming the lariat) from the 3' splice site, and the inclusion or omission of structural elements such as a coordination loop in domain I, which is present in IIB and IIC introns but not IIA. Group II introns also form very complicated RNA Tertiary Structure.
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https://en.wikipedia.org/wiki?curid=7916185
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Internet Engineering Task Force's RFC 6157 describes the necessary mechanisms to guarantee that SIP works successfully between both Internet Protocol versions during the transition to IPv6. While SIP signaling messages can be transmitted through heterogeneous IPv4/IPv6 networks as long as proxy servers and DNS entries are properly configured to relay messages across both networks according to these recommendations, user agents will need to implement extensions so that they can directly exchange media streams. These extensions are related to the Session Description Protocol offer/answer initial exchange, that will be used to gather the IPv4 and IPv6 addresses of both ends so that they can establish a direct communication.
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https://en.wikipedia.org/wiki?curid=44402859
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Hollywood featured the B-17 in its period films, such as director Howard Hawks' "Air Force" starring John Garfield and "Twelve O'Clock High" starring Gregory Peck. Both films were made with the full cooperation of the United States Army Air Forces and used USAAF aircraft and (for "Twelve O'Clock High") combat footage. In 1964, the latter film was made into a television show of the same name and ran for three years on ABC TV. Footage from "Twelve O' Clock High" was also used, along with three restored B-17s, in the 1962 film "The War Lover". An early model YB-17 also appeared in the 1938 film "Test Pilot" with Clark Gable and Spencer Tracy, and later with Clark Gable in "Command Decision" in 1948, in "Tora! Tora! Tora!" in 1970, and in "Memphis Belle" with Matthew Modine, Eric Stoltz, Billy Zane, and Harry Connick Jr. in 1990. The most famous B-17, the "Memphis Belle", toured the U. S. with her crew to reinforce national morale (and to sell war bonds). She was featured in a USAAF documentary, "".
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https://en.wikipedia.org/wiki?curid=4997
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Electrical and electrochemical detection are easily adapted for portability and miniaturization, especially in comparison to optical detection. In amperometric biosensors, an enzyme-catalyzed redox reaction causes a redox electron current that is measured by a working electrode. Amperometric biosensors have been used in bio-MEMS for detection of glucose, galactose, lactose, urea, and cholesterol, as well as for applications in gas detection and DNA hybridization. In potentiometric biosensors, measurements of electric potential at one electrode are made in reference to another electrode. Examples of potentiometric biosensors include ion-sensitive field effect transistors (ISFET), Chemical field-effect transistors (chem-FET), and light-addressable potentiometric sensors (LAPS). In conductometric biosensors, changes in electrical impedance between two electrodes are measured as a result of a biomolecular reaction. Conductive measurements are simple and easy to use because there is no need for a specific reference electrode, and have been used to detect biochemicals, toxins, nucleic acids, and bacterial cells.
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https://en.wikipedia.org/wiki?curid=19081158
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The finite element method obtained its real impetus in the 1960s and 1970s by the developments of J. H. Argyris with co-workers at the University of Stuttgart, R. W. Clough with co-workers at UC Berkeley, O. C. Zienkiewicz with co-workers Ernest Hinton, Bruce Irons and others at Swansea University, Philippe G. Ciarlet at the University of Paris 6 and Richard Gallagher with co-workers at Cornell University. Further impetus was provided in these years by available open source finite element programs. NASA sponsored the original version of NASTRAN, and UC Berkeley made the finite element program SAP IV widely available. In Norway the ship classification society Det Norske Veritas (now DNV GL) developed Sesam in 1969 for use in analysis of ships. A rigorous mathematical basis to the finite element method was provided in 1973 with the publication by Strang and Fix. The method has since been generalized for the numerical modeling of physical systems in a wide variety of engineering disciplines, e.g., electromagnetism, heat transfer, and fluid dynamics.
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https://en.wikipedia.org/wiki?curid=18233581
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The "Galileo" spacecraft, which orbited Jupiter from 1995 to 2003, provided a comprehensive coverage of Jupiter's magnetic field near the equatorial plane at distances up to 100 "R". The regions studied included the magnetotail and the dawn and dusk sectors of the magnetosphere. While Galileo successfully survived in the harsh radiation environment of Jupiter, it still experienced a few technical problems. In particular, the spacecraft's gyroscopes often exhibited increased errors. Several times electrical arcs occurred between rotating and non-rotating parts of the spacecraft, causing it to enter safe mode, which led to total loss of the data from the 16th, 18th and 33rd orbits. The radiation also caused phase shifts in "Galileo"'s ultra-stable quartz oscillator.
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https://en.wikipedia.org/wiki?curid=8482163
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FTP has become important because banks are expected to state their funding costs accurately as a regulatory requirement because funding costs affect a bank's liquidity reporting. Failure and bail-outs of banks have made reported liquidity a hot topic. FTP calculation is complicated by several factors which make the calculation of the revenue adjustment necessarily difficult. Factors affecting funding cost include the length of time an asset or liability is repaid (Liquidity Term Premium), the extent to which an asset has been or can be securitised (which affects its liquidity) and the behaviour of customers in particular product/customer niches such as customers' propensity to withdraw long-term deposits at a penalty or to repay obligations such as mortgages early, all which affect real funding cost. This behaviour factor complicates the calculation of FTP and has required significant and expensive changes to banking systems. Balance sheets now incorporate new attributes for customer and product which were not previously significant reporting dimensions.
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https://en.wikipedia.org/wiki?curid=9188656
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The work of the neuropathologist consists largely of examining autopsy or biopsy tissue from the brain and spinal cord to aid in diagnosis of disease. Tissues are also observed through the eyes, muscles, surfaces of organs, and tumors. The biopsy is usually requested after a mass is detected by radiologic imaging, the imaging in turn driven by presenting signs and symptoms of a patient. CT scans are also used to discover issues in the patient. As for autopsies, the principal work of the neuropathologist is to help in the post-mortem diagnosis of various forms of dementia and other conditions that affect the central nervous system. Tissue samples are researched within the lab for diagnosis as well as forensic investigations.
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https://en.wikipedia.org/wiki?curid=1740329
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One major area of application for microfluidic devices is the separation and sorting of different fluids or cell types. Recent developments in the microfluidics field have seen the integration of microfluidic devices with magnetophoresis: the migration of particles by a magnetic field. This can be accomplished by sending a fluid containing at least one magnetic component through a microfluidic channel that has a magnet positioned along the length of the channel. This creates a magnetic field inside the microfluidic channel which draws magnetically active substances towards it, effectively separating the magnetic and non-magnetic components of the fluid. This technique can be readily utilized in industrial settings where the fluid at hand already contains magnetically active material. For example, a handful of metallic impurities can find their way into certain consumable liquids, namely milk and other dairy products. Conveniently, in the case of milk, many of these metal contaminants exhibit paramagnetism. Therefore, before packaging, milk can be flowed through channels with magnetic gradients as a means of purifying out the metal contaminants.
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https://en.wikipedia.org/wiki?curid=18906
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Principal photography began on 4 January 2019 in Mumbai and was shot as a multilingual, with scenes simultaneously filmed in the Hindi, Tamil, and English languages. A few days after the start of the shoot, Mahadevan left the project owing to prior commitments and Madhavan took over as the project's sole director. Film director and writer Prajesh Sen, who had previously co-written "Ormakalude Bhramanapadham" and worked on a documentary titled "Nambi The Scientist", joined the project as a co-director. Sukhmani Sadana worked on the film as an additional screenplay and dialogues writer. Scenes featuring Madhavan as the aged Narayanan were filmed first, with the actor taking up to 14 hours to get into the look following extensive make-up. During the first schedule in India, Simran joined the film's cast to portray the wife of the lead character, while actors Shah Rukh Khan and Suriya agreed to make cameo appearances in the Hindi and Tamil versions respectively as themselves. Both of the actors did not charge a fee for their participation in the film. Other actors who joined the cast during the production were Tamil actor Jagan to portray a scientist, Rajit Kapur to feature as Indian physicist Vikram Sarabhai in the Hindi and English versions and Ravi Raghavendra as Vikram Sarabhai in the Tamil version.
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https://en.wikipedia.org/wiki?curid=58932491
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In 1927, D. R. Hartree introduced a procedure, which he called the self-consistent field method, to calculate approximate wave functions and energies for atoms and ions. Hartree sought to do away with empirical parameters and solve the many-body time-independent Schrödinger equation from fundamental physical principles, i.e., ab initio. His first proposed method of solution became known as the "Hartree method", or "Hartree product". However, many of Hartree's contemporaries did not understand the physical reasoning behind the Hartree method: it appeared to many people to contain empirical elements, and its connection to the solution of the many-body Schrödinger equation was unclear. However, in 1928 J. C. Slater and J. A. Gaunt independently showed that the Hartree method could be couched on a sounder theoretical basis by applying the variational principle to an ansatz (trial wave function) as a product of single-particle functions.
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https://en.wikipedia.org/wiki?curid=475393
| 768,513
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1,732,563
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On April 24, 1787, Georgetown landowner John Threlkeld donated a plot of land to Carroll, which was ultimately where he founded Holy Trinity Church. In April 1788, construction began at a larger neighboring plot on Georgetown's first building, later called "Old South", leading Carroll to write "We shall begin the building of our Academy this summer. On this Academy are built all my hopes of permanency and success of our holy religion in the United States." On January 23, 1789, John Carroll, Robert Molyneux and completed the purchase from Threlkeld and William Deakins, Jr. for "seventy five pounds current money" of the acre and a half on which construction had already started. This land became the core of Georgetown's campus. As a result, the university celebrates this date as its founding.
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https://en.wikipedia.org/wiki?curid=9623056
| 1,731,587
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In the late 1950s the Polish Navy decided to develop fast torpedo boats of own design, to supplement Soviet-origin project 183 (P-6) class torpedo boats. It was decided to use a gas turbine for propulsion and arm them with four torpedo tubes. Due to lack of previous experience in designing such craft, development was very long. In order to test the technology, a single experimental project 663D torpedo boat was built, ORP "Błyskawiczny". Her building started in 1961 and she entered service in 1965. Trials revealed some faults, and further development work was carried out. The result were the boats of the final project 664. They shared a similar silhouette, hull shape and a propulsion fit of 4 diesel and a TM-1 gas turbine engine in a CODAG arrangement. The gas turbine itself was an adaptation of a licence-built Klimov VK-1 aircraft jet engine. The gas turbine being used at speeds above 12 knots.
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https://en.wikipedia.org/wiki?curid=8441910
| 2,153,014
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This is a prolific nitrogen-fixing and phosphorus reducing species of bacteria that fixes approximately half of the nitrogen in the food chain of the ocean and contributes to the turn over of phosphorus. Unlike other bacteria, it can also photosynthesize. This is a colonial species that forms long filaments and tends to accumulate with other "Trichodesmium". It is gram-negative and motile. Some of the bacteria in the colony fix the nitrogen, and others are specialized for photosynthesis. However, the two processes must be done with two of them, because the oxygen byproduct that results from photosynthesis would interfere with the nitrogen-fixing process. This is done either by, having two separate cells share resources with each other or by separating the processes by time in the same cell. If the cells are physically separated, then one cell specializes as a diazotroph and undergoes nitrogen fixation while other cells undergo photosynthesis. Alternatively, "T. erythraeum" also has been shown to separate the processes of photosynthesis and nitrogen fixation in the same cell by separating the time at which these processes occur. When this is done "T. erythraeum" will stop photosynthesizing at midday or night and begin oxygen scavenging as it begins nitrogen fixation. Additionally, "T. erythraeum" have gas vesicles that account for 60–70% of the cell's volume. These vesicles allow "T. erythraeum" to move in the water coulomb up to 200 m using its buoyancy based on the concentrations of carbohydrates in order to search out nutrients such as nitrogen, phosphorus and iron.
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https://en.wikipedia.org/wiki?curid=51136517
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When the power company's voltage becomes distorted due to harmonics, losses in other loads such as normal fixed-speed AC motors are increased. This condition may lead to overheating and shorter operating life. Also, substation transformers and compensation capacitors are affected negatively. In particular, capacitors can cause resonance conditions that can unacceptably magnify harmonic levels. To limit the voltage distortion, owners of VFD load may be required to install filtering equipment to reduce harmonic distortion below acceptable limits. Alternatively, the utility may adopt a solution by installing filtering equipment of its own at substations affected by the large amount of VFD equipment being used. In high-power installations, harmonic distortion can be reduced by supplying multi-pulse rectifier-bridge VFDs from transformers with multiple phase-shifted windings.
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https://en.wikipedia.org/wiki?curid=1845708
| 136,497
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According to Eliasson, the decision to power the type using turboprop engines rather that jet engines had been provided as one of the reasons for Saab deciding to close down the project; another major factor had been the increasingly competitive and politicised regional airliner market in which various competing airlines were alleged to have substantially benefited from government subsidies, while the Swedish government were unwilling to make such commitments to Saab's civil projects. According to authors Sören Eriksson and Harm-Jan Steenhuis, while the 340 had been faster than jet-powered competitors such as the Fokker 100 and British Aerospace 146, it had no clear advantage in terms of payload or range; as the regional airliner market became increasingly crowded, newer types such as the Bombardier CRJ200 and Embraer ERJ 145 family, which did have an advantage over the 340, had led to diminished sales.
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https://en.wikipedia.org/wiki?curid=469211
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The season produced a domestic double of La Liga and Copa del Rey wins, with Barça coming out on top in a closely fought title race and defeating newly crowned Europa League winners Sevilla in the Copa del Rey final after extra time. However, Barça failed to clinch its second sextuple after 2009 by losing the Supercopa de España to Copa del Rey runners-up Athletic Bilbao (0–4 away, 1–1 home). Barcelona did manage to finish the year with five trophies, repeating 2011, by clinching the UEFA Super Cup and FIFA Club World Cup titles. Barcelona was also aiming and considered a favourite to repeat as Champions League winners to become the first team in the modern UCL era to do so, but they were knocked out by Atlético Madrid in the quarter-finals (2–1 home, 0–2 away) in a strange repeat of their meeting at the same stage two years prior.
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https://en.wikipedia.org/wiki?curid=46735387
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Since August 2004, an interim storage facility has been established on the grounds of the nuclear power plant for spent fuel elements with a heavy metal weight of 2,250 tonnes. It contains 192 storage spaces and was placed in operation in 2006. € 30 million have been budgeted for this. Construction of the building (104 m long, 38 m wide, and 18 m tall) was completed at the end of 2005. After interior fitting with electrical, heating, and ventilation equipment, installation of heavyweight hoists, and remaining exterior work, on 25 August 2006 the interim storage facility was opened and the first containers from the power plant moved in.
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https://en.wikipedia.org/wiki?curid=12542929
| 1,276,891
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Laser Spectroscopy (or Cavity ring-down spectroscopy, CRDS) is able to directly measure D/H, O/O and OO isotope compositions in water or methane. The application of laser spectroscopy to hydrogen isotopes was first reported by Bergamaschi et al. in 1994. They directly measured CHD/CH in atmospheric methane using a lead salt tunable diode laser spectroscopy. The development of CRDS was first reported by O'Keefe et al. in 1988. In 1999, Kerstel et al. successfully applied this technique to determine D/H in water sample. The system consists of a laser and a cavity equipped with high finesse reflectivity mirrors. Laser light is injected into the cavity, at which the resonance takes place due to the constructive interference. The laser then is turned off. The decay of light intensity is measured. In the presence of a water sample, the photo-absorption by water isotopologues follows the kinetic law. The optical spectrum is obtained by recording ring-down time of the HO spectral features of interest at certain laser wavelength. The concentration of each isotopologue is proportional to the area under each measured isotopologue spectral feature.
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https://en.wikipedia.org/wiki?curid=50525886
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Batara Surya was hit when Anoman blamed Batara Surya for what happened to his mother, Dewi Anjani and her grandmother, who had been cursed by her husband. Anoman feels Batara Surya must be responsible so Anoman with his magic collects clouds from all over the world to cover the natural world so that the rays of the sun cannot reach the earth. Fortunately, this incident can be resolved amicably so that Anoman voluntarily removes the clouds again so that the natural world is exposed to the sun again. Surya has three queens namely Saranyu (also called Saraniya, Saranya, Sanjna, or Sangya), Ragyi, and Prabha. Saranyu is the mother of Vaiwaswata Manu (seventh Manu, the present day), and twins Yama (god of death) and his sister Yami. She also bore him the twins known as Aswin, and the gods. Saranyu, unable to witness the bright light from Surya, created a clone of herself named Chaya, and orders her to act as Surya's wife during her absence. Chaya had two sons by "Surya-Sawarni Manu" (the eighth Manu, the next) and Sani (the god of the planet Saturn), and two daughters-Tapti and Vishti. Batara Surya also had a son, Rewanta, or Raiwata, from Ragyi. Interestingly, Surya's two sons – Sani and Yama – are responsible for judging humans' lives, after death. Sani gives the results of one's actions through one's life through appropriate punishments and rewards, while Yama gives the results of one's actions after death.
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IBM (which counts among its founding patents a method for mechanical tabulation of population statistics for the United States Census Bureau in 1897), launched its “Smarter Cities” marketing initiative in 2008. In 2010, Cisco Systems, with $25 million from the Clinton Foundation, established its Connected Urban Development program in partnership with San Francisco, Amsterdam, and Seoul. In 2011, a Smart City Expo World Congress was held in Barcelona, in which 6000 people from 50 countries attended. The European Commission in 2012 established the Smart Cities Marketplace, a centralized hub for urban initiatives in the European Union.
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https://en.wikipedia.org/wiki?curid=12592050
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Held 23–25 October at Physikalisch-Technischen Reichsanstalt at Charlottenburg. The 1904 Congress recommended holding an international conference to address discrepancies in the electrical units and their interpretation. Emil Warburg, president of the Physikalisch-Technische Reichsanstalt in Germany, invited representatives from corresponding national laboratories in the United States (National Bureau of Standards), the United Kingdom (National Physical Laboratory), and the official standards commissions in Austria and Belgium to an informal conference on electrical standards and units. Additionally Mascart (France), Rayleigh (United Kingdom) and Carhart (USA) were invited because of their expertise and influence. Thirteen of the fifteen invited persons participated in the conference, six from the Reichsanstalt, two from the Belgian Commission on Electrical Units, two from the Austrian Commission on Standardization, Richard Glazebrook from the National Physical Laboratory, Mascart, and Carhart. The non-attendees were Samuel Wesley Stratton, director of the National Bureau of Standard, who sent three papers outlining the positions and proposals of the Bureau, and Rayleigh. A proceedings was published.
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https://en.wikipedia.org/wiki?curid=14555039
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Like all other organisms, plants do not lead solitary lives, as there are myriads of microbes and viruses living around and within them. Some microbes, whether endophytic or epiphytic, play diverse roles in supporting healthy plant growth, whereas others are pathogenic, which can become dominant over the beneficial ones to cause disease. In recent years, various cutting-edge tools developed for studying the associations between microbes and plants and extensive modern research on plant microbiomes have dramatically furthered knowledge on ecological functions and key roles of the plant microbiome in supporting plant adaptability to dynamic environments. Currently, plant-associated microorganisms are considered reservoirs of additional genes and traits, which are critical to the growth and development of the host. Furthermore, the plant pathobiome—which represents the disease-causing agents in the context of the interaction between the microbial communities and plant host in its biotic environment—is another important component of the plant microbiome that remains relatively understudied.
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https://en.wikipedia.org/wiki?curid=65429792
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The term "android" appears in US patents as early as 1863 in reference to miniature human-like toy automatons. The term "android" was used in a more modern sense by the French author Auguste Villiers de l'Isle-Adam in his work "Tomorrow's Eve" (1886). This story features an artificial humanlike robot named Hadaly. As said by the officer in the story, "In this age of Realien advancement, who knows what goes on in the mind of those responsible for these mechanical dolls." The term made an impact into English pulp science fiction starting from Jack Williamson's "The Cometeers" (1936) and the distinction between mechanical robots and fleshy androids was popularized by Edmond Hamilton's Captain Future stories (1940–1944).
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https://en.wikipedia.org/wiki?curid=713
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On 31 December 2006, Dungeness A ceased power generation after over forty years of operation. Defuelling was completed in June 2012 with all fuel having been sent to Sellafield for reprocessing. After the site was declared fuel-free, demolition works accelerated beginning with the demolition of the turbine hall in June 2015. Similar to other legacy Magnox stations, the site will undergo decommissioning where radiologically contaminated equipment is removed and redundant structures demolished. Once complete, the reactor buildings will be re-cladded to ensure they are able to remain an effective barrier to the elements and the facility will enter a 'care and maintenance' stage.
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https://en.wikipedia.org/wiki?curid=645131
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The was a school established to train line officers for the Imperial Japanese Navy. It was originally located in Nagasaki, moved to Yokohama in 1866, and was relocated to Tsukiji, Tokyo in 1869. It moved to Etajima, Hiroshima in 1888. Students studied for three or four years, and upon graduation were ordered (warranted) as Midshipmen, commissioned to the rank of Ensign/Acting Sub-Lieutenant after a period of active duty and an overseas cruise. In 1943, a separate school for naval aviation was opened in Iwakuni, and in 1944, another naval aviation school was established in Maizuru. The Academy was closed in 1945, when the Imperial Japanese Navy was abolished. The Naval Academy Etajima opened in 1956 and the site now serves as the location for Officer Candidate School of the Japan Maritime Self-Defense Force.
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https://en.wikipedia.org/wiki?curid=6797774
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Ballast is used in surface vessels to alter the draft, trim, list and stability. It may also be used to modify structural load distribution, usually the longitudinal load distribution which affects hogging and sagging stresses. It may also be used to change the moments of inertia which affect motion in a seaway. International agreements under the Safety Of Life At Sea (SOLAS) Convention require that cargo vessels and passenger ships be constructed to withstand certain kinds of damage. The criteria specify the separation of compartments within the vessel, and the subdivision of those compartments. These International agreements rely on the states that signed the agreement to implement the regulations within their waters and on vessels entitled to fly their flag. Ballast may be used to compensate for stability losses due to flooding of some compartments.
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https://en.wikipedia.org/wiki?curid=3619680
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Carbon nanofoam clusters can be synthesized through high-repetition-rate laser ablation in inert gases such as argon. Short (fs), low-energy (µJ) pulses delivered at high rates of repetition (10 kHz – 100 MHz) generate carbon vapors for deposition. Ambient gas is heated from room temperature with the atomized carbon which leads to an increase in the partial density of the carbon in the chamber. In optimal conditions, the inert gas does not cool down but maintains its high temperature between cycles of formation. Subsequent cycles in the chamber are carried out at temperatures above the formation threshold temperature initiating sp bonding. The increase in density and temperature promotes favorable conditions for the formation of carbonaceous clusters. The rate of consumption exceeds the rate of evaporation by laser ablation and thus the formation is in a non-equilibrium state.
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https://en.wikipedia.org/wiki?curid=739628
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Barrier and Isolator designs are used throughout the industries, from sterile injectable drug filling to cytotoxic sterile drug compounding to electronics manufacturing to orange juice filling. Pharmaceutical industry and pharmacy compounding isolators are used for maintaining sterility of a drug, and that is the focus of this article. This type of strict design and control is important when producing sterile medicines because consumers receiving injections, surgical irrigation fluid, or other "parenterally"-administered drugs are often highly vulnerable to infection. As a result, contaminated drugs have caused grave (e.g., permanent injury, death) consequences for the consumer. The sterility of other dosage forms, such as ophthalmic, is similarly important, as blindness or partial loss of vision has occurred due to intrinsically contaminated eye medications.
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https://en.wikipedia.org/wiki?curid=10127780
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Follicular unit excision takes considerable time and expense to learn and to develop skills to a high standard. The first part of the procedure involves making an incision with a circular cutting punch around the hair follicle through the epidermis into the subcutaneous tissue in order to release the follicle from the underlying tissue. The hair follicle grouping or follicular unit is a full thickness skin graft containing epidermis, dermis and fat. The graft is then subsequently extracted utilizing suction, or forceps or specialized aid to extraction instruments (ATOE) and carefully preserved until it is time to reimplant into the donor scalp or recipient area. Each follicular unit is excised one at a time being very careful not to cut the underlying hair matrix cells and injure or fracture the graft with transection. Additional care must also be taken when extracting the grafts with forceps to insure the hair follicles are not crushed or manipulated too aggressively which could also affect the growth. Hence FUE requires careful attention to detail and time. Consequently, many physicians are not able to excise as many grafts in one day compared to traditional FUT due to the time involved.
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https://en.wikipedia.org/wiki?curid=9320155
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A characteristic feature of primary care is that doctors’ often care for several patients who are related to each other. They also often care for a number of individuals and families who live and/or work in close proximity, and whose lives are intimately related to each other. Particularly though not exclusively in rural areas, the same applies to the doctor and to his staff. This can be a considerable strength of general practice, since doctors gain a fuller understanding of the social context in which their patients live and become ill. It can also pose ethical problems, however particularly in conflicts between duties to different individuals – family members, employers and employees, and even between friends, when the illness of one affects the life or health of another. Confidentiality can also be a problem, as patients may not understand or accept that information given to the doctor by one family member may not be divulged to others.
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https://en.wikipedia.org/wiki?curid=34196819
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The root patents of LFP compounds are held by four organizations. University of Texas-Austin for the discovery of the material. Hydro-Québec, Université de Montréal and the French National Center for Scientific Research (CNRS) for the carbon coating that enhance its conductivity and actually makes LFP suitable for industrial developments. These patents underlie mature mass production technologies. The largest production capacity is up to 250 tons per month. The key feature of from A123 is the nano-LFP, which modifies its physical properties and adds noble metals in the anode, as well as the use of special graphite as the cathode.
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https://en.wikipedia.org/wiki?curid=13079232
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In 2011, the Dutch authority investigating child pornography discovered the IP address of a Tor onion service site called "Pedoboard" from an unprotected administrator's account and gave it to the FBI, who traced it to Aaron McGrath. After a year of surveillance, the FBI launched "Operation Torpedo" which resulted in McGrath's arrest and allowed them to install their Network Investigative Technique (NIT) malware on the servers for retrieving information from the users of the three onion service sites that McGrath controlled. The technique, exploiting a Firefox/Tor browser's vulnerability that had been patched and targeting users that had not updated, had a Flash application pinging a user's IP address directly back to an FBI server, and resulted in revealing at least 25 US users as well as numerous users from other countries. McGrath was sentenced to 20 years in prison in early 2014, with at least 18 other users including a former Acting HHS Cyber Security Director being sentenced in subsequent cases.
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https://en.wikipedia.org/wiki?curid=20556944
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SPAAG development continued through the early 1950s with ever-larger guns, improving the range and allowing the engagement to take place at longer distances where the crossing angle was smaller and aiming was easier. Examples including the 40 mm U.S. M42 Duster and the 57 mm Soviet ZSU-57-2. However, both were essentially obsolete before they entered service, and found employment solely in the ground-support role. The M42 was introduced to the Vietnam War to counter an expected North Vietnamese air offensive, but when this failed to materialize it was used as an effective direct-fire weapon. The ZSU-57 found similar use in the Yugoslav Wars, where its high-angle fire was useful in the mountainous terrain.
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https://en.wikipedia.org/wiki?curid=2288
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After the completion of the survey in 1968, it was used occasionally as an educational instrument as part of the Green Bank radio astronomy summer schools. In 1987 it was restored and upgraded for full use as an educational telescope, including by local science teachers as part of the Secondary Science Teachers Institute (SSTI). The restoration reused the 1960 dipole antenna and radome from the Tatel Telescope, which was used during the Project Ozma. A substantial part of the spectrometer was reused from the 300 Foot Telescope. In 1991 this changed to the 'Learning to Investigate the Universe' (LITU) project, changing again in 1994 to Research Experiences in Teacher Preparation (RETP). It has also been used by the annual Educational Research in Radio Astronomy (ERIRA) program since 1992, and Green Bank Observatory's "Radio Astronomer for a Day" program for K–12 students.
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https://en.wikipedia.org/wiki?curid=69514030
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Shellsort, discovered by Donald Shell in 1959, is a comparison sort which divides a list to be sorted into sublists and sorts them separately. The sorted sublists are then merged, reconstituting a partially-sorted list. This process repeats a number of times (the number of passes). The difficulty of analyzing the complexity of the sorting process is that it depends on the number formula_2 of keys to be sorted, on the number formula_89 of passes and the increments governing the scattering in each pass; the sublist is the list of keys which are the increment parameter apart. Although this sorting method inspired a large number of papers, only the worst case was established. For the average running time, only the best case for a two-pass Shellsort and an upper bound of formula_90 for a particular increment sequence for three-pass Shellsort were established. A general lower bound on an average formula_89-pass Shellsort was given which was the first advance in this problem in four decades. In every pass, the comparison sort moves a key to another place a certain distance (a path length). All these path lengths are logarithmically coded for length in the correct order (of passes and keys). This allows the reconstruction of the unsorted list from the sorted list. If the unsorted list is incompressible (or nearly so), since the sorted list has near-zero Kolmogorov complexity (and the path lengths together give a certain code length) the sum must be at least as large as the Kolmogorov complexity of the original list. The sum of the path lengths corresponds to the running time, and the running time is lower-bounded in this argument by formula_92. This was improved to a lower bound of
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https://en.wikipedia.org/wiki?curid=48885825
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The armour-piercing concept calls for more penetration capability than the target's armour thickness. The penetrator is a pointed mass of high-density material that is designed to retain its shape and carry the maximum possible amount of energy as deeply as possible into the target. Generally, the penetration capability of an armour-piercing round increases with the projectile's kinetic energy and also with concentration of that energy in a small area. Thus, an efficient means of achieving increased penetrating power is increased velocity for the projectile. However, projectile impact against armour at higher velocity causes greater levels of shock. Materials have characteristic maximum levels of shock capacity, beyond which they may shatter, or otherwise disintegrate. At relatively high impact velocities, steel is no longer an adequate material for armour-piercing rounds. Tungsten and tungsten alloys are suitable for use in even higher-velocity armour-piercing rounds, due to their very high shock tolerance and shatter resistance, and to their high melting and boiling temperatures. They also have very high density. Aircraft and tank rounds sometimes use a core of depleted uranium. Depleted-uranium penetrators have the advantage of being pyrophoric and self-sharpening on impact, resulting in intense heat and energy focused on a minimal area of the target's armour. Some rounds also use explosive or incendiary tips to aid in the penetration of thicker armour. High explosive incendiary/armour piercing ammunition combines a tungsten carbide penetrator with an incendiary and explosive tip.
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https://en.wikipedia.org/wiki?curid=79266
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Bailey returned prior to the start of 1946 season and resumed his coaching duties. From 1947–1950, the program won four consecutive PCC North Division titles. This run culminated in the program's first College World Series appearance in 1950, the first College World Series played at Rosenblatt Stadium in Omaha, Nebraska. To qualify, the Cougars defeated Stanford to win the PCC Tournament. At the World Series, WSC opened with three consecutive wins over Tufts, Alabama, and Rutgers, but lost 12–1 to defending champion Texas, who had lost their opener in the double-elimination tournament. The last two teams remaining and both with one loss, the Cougars and Longhorns met again three days later in the national championship game, which Texas won 3–0. Future major leaguers Ted Tappe and Gene Conley played on the 1950 team.
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https://en.wikipedia.org/wiki?curid=30079048
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The majority of antibiotics used to treat "M. pneumoniae" infections are targeted at bacterial rRNA in ribosomal complexes, including macrolides, tetracycline, ketolides, and fluoroquinolone, many of which can be administered orally. Macrolides are capable of reducing hyperresponsiveness and protecting the epithelial lining from oxidative and structural damage, however they are capable only of inhibiting bacteria (bacteriostatic) and are not able to cause bacterial cell death. The most common macrolides used in the treatment of infected children in Japan are erythromycin and clarithromycin, which inhibit bacterial protein synthesis by binding 23S rRNA. Administration of antibiotics has been proven to reduce the longevity and intensity of "M. pneumoniae" infections in comparison to cases left untreated. Additionally, some high-dose steroid therapies have shown to reverse neurological effects in children with complicated infections.
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https://en.wikipedia.org/wiki?curid=466746
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Without oxygen, pyruvate (pyruvic acid) is not metabolized by cellular respiration but undergoes a process of fermentation. The pyruvate is not transported into the mitochondrion but remains in the cytoplasm, where it is converted to waste products that may be removed from the cell. This serves the purpose of oxidizing the electron carriers so that they can perform glycolysis again and removing the excess pyruvate. Fermentation oxidizes NADH to NAD so it can be re-used in glycolysis. In the absence of oxygen, fermentation prevents the buildup of NADH in the cytoplasm and provides NAD for glycolysis. This waste product varies depending on the organism. In skeletal muscles, the waste product is lactic acid. This type of fermentation is called lactic acid fermentation. In strenuous exercise, when energy demands exceed energy supply, the respiratory chain cannot process all of the hydrogen atoms joined by NADH. During anaerobic glycolysis, NAD regenerates when pairs of hydrogen combine with pyruvate to form lactate. Lactate formation is catalyzed by lactate dehydrogenase in a reversible reaction. Lactate can also be used as an indirect precursor for liver glycogen. During recovery, when oxygen becomes available, NAD attaches to hydrogen from lactate to form ATP. In yeast, the waste products are ethanol and carbon dioxide. This type of fermentation is known as alcoholic or ethanol fermentation. The ATP generated in this process is made by substrate-level phosphorylation, which does not require oxygen.
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The plasma experiment's goal was to study the ionized gases (plasma) of the solar wind, the temperature and density of its electrons, and how the planets affected the velocity of the plasma stream. The experiment contained two components, facing in opposite directions. The Scanning Electrostatic Analyzer was aimed toward the Sun and could detect positive ions and electrons, which were separated by a set of three concentric hemispherical plates. The Scanning Electron Spectrometer has aimed away from the Sun, and detected only electrons, using just one hemispherical plate. The instruments could be rotated about 60° to either side. By gathering data on the solar wind's movement around Mercury, the plasma experiment could be used to verify the magnetometer's observations of Mercury's magnetic field. Using the plasma detectors, Mariner 10 gathered the first "in situ" solar wind data from inside Venus' orbit.
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For 1982 the better equipped 504 Pickup GR was added, these received some chrome touches and luxuries such as a clock and door-mounted armrests. Externally, the GR was set apart by black rubber bumper overriders, different hubcaps and a modicum of chrome ornamentation (the standard version received a grille and bumpers painted light gray). By 1984, the chrome parts were dropped in favor of a cleaner, more modern appearance. The GR was renamed "Confort" in 1987, at least in the French domestic market. This is also when the 1.6 petrol option was discontinued. The GR received an version of the 504's 1.8-liter petrol engine, while the GRD had the 2.3-liter diesel. The French models were then renamed "Entrepreneur" in 1988 (by now with a 2.1 Diesel) and was upgraded to the 2.3-liter diesel for 1990. Trim levels received differing names in various markets; in Britain, most later 504 Pickups received "GL" badging. For 1995 and 1996, subsequent to the end of pickup production in France, Argentinian 504 Pickups were exported to France. These can be recognized by the large modernized front bumper and redesigned dashboard.
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https://en.wikipedia.org/wiki?curid=456445
| 218,347
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774,008
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Human traits that emerged recently include the ability to free-dive for long periods of time, adaptations for living in high altitudes where oxygen concentrations are low, resistance to contagious diseases (such as malaria), light skin, blue eyes, lactase persistence (or the ability to digest milk after weaning), lower blood pressure and cholesterol levels, retention of the median artery, reduced prevalence of Alzheimer's disease, lower susceptibility to diabetes, genetic longevity, shrinking brain sizes, and changes in the timing of menarche and menopause.
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https://en.wikipedia.org/wiki?curid=54472601
| 773,592
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768,236
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Louis Pasteur was unable to find a causative agent for rabies and speculated about a pathogen too small to be detected by microscopes. In 1884, the French microbiologist Charles Chamberland invented the Chamberland filter (or Pasteur-Chamberland filter) with pores small enough to remove all bacteria from a solution passed through it. In 1892, the Russian biologist Dmitri Ivanovsky used this filter to study what is now known as the tobacco mosaic virus: crushed leaf extracts from infected tobacco plants remained infectious even after filtration to remove bacteria. Ivanovsky suggested the infection might be caused by a toxin produced by bacteria, but he did not pursue the idea. At the time it was thought that all infectious agents could be retained by filters and grown on a nutrient medium—this was part of the germ theory of disease.
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https://en.wikipedia.org/wiki?curid=32772
| 767,824
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Adipose tissue contains many small blood vessels. In the integumentary system, which includes the skin, it accumulates in the deepest level, the subcutaneous layer, providing insulation from heat and cold. Around organs, it provides protective padding. However, its main function is to be a reserve of lipids, which can be oxidised to meet the energy needs of the body and to protect it from excess glucose by storing triglycerides produced by the liver from sugars, although some evidence suggests that most lipid synthesis from carbohydrates occurs in the adipose tissue itself. Adipose depots in different parts of the body have different biochemical profiles. Under normal conditions, it provides feedback for hunger and diet to the brain.
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https://en.wikipedia.org/wiki?curid=419094
| 369,547
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1,934,139
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The ASRT publishes two peer-reviewed research journals. The bimonthly journal "Radiologic Technology" keeps readers informed about advances in technology and patient care. It also offers ASRT members the opportunity to earn continuing education credit through its Directed Reading program. "Radiation Therapist", published twice a year, focuses on technical advances in radiation oncology. It, too, features a Directed Reading program. "ASRT Scanner" is the society's member magazine. In addition, the ASRT operates a website which contains news, information about the profession, educational material for patients and a variety of professional resources for radiologic technologists.
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https://en.wikipedia.org/wiki?curid=12466214
| 1,933,031
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460,700
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The use of antibiotics in livestock also has the potential to introduce antibiotic-resistant bacteria to humans via environmental exposure or inhalation of airborne bacteria. Antibiotics given to livestock in sub-therapeutic concentrations to stimulate growth when there is no diagnosis of disease – a practice still permitted in some countries – may kill some, but not all, of the bacterial organisms in the animal, possibly leaving those that are naturally antibiotic-resistant in the environment. Hence the practice of using antibiotics for growth stimulation could result in selection for resistance. Antibiotics are not fully digested and processed in the animal or human gut, therefore, an estimated 40–90% of the antibiotics ingested are excreted in urine and/or faeces. This means that as well as finding antibiotics in human sewage and animal manure, both can also contain antibiotic-resistant bacteria which have developed "in vivo" or in the environment. When animal manures are stored inadequately or applied as fertiliser, this can then spread bacteria to crops and into run-off water. Antibiotics have been found in small amounts in crops grown in fertilised fields, and detected in runoff from animal waste-fertilised land. Composting has been shown to reduce the presence of various antibiotics by 20–99%, but one study found that chlortetracycline, an antibiotic used in livestock feed in China, degraded at different rates dependent on the animal it was fed to, and that manure composting was not sufficient to ensure the microbial degradation of the antibiotic.
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https://en.wikipedia.org/wiki?curid=40364158
| 460,474
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However, Nick Bostrom's "orthogonality thesis" argues against this, and instead states that, with some technical caveats, more or less any level of "intelligence" or "optimization power" can be combined with more or less any ultimate goal. If a machine is created and given the sole purpose to enumerate the decimals of formula_1, then no moral and ethical rules will stop it from achieving its programmed goal by any means necessary. The machine may utilize all physical and informational resources it can to find every decimal of pi that can be found. Bostrom warns against anthropomorphism: a human will set out to accomplish his projects in a manner that humans consider "reasonable", while an artificial intelligence may hold no regard for its existence or for the welfare of humans around it, and may instead only care about the completion of the task.
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https://en.wikipedia.org/wiki?curid=46583121
| 191,868
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The Exploratorium aimed to introduce and inspire, as well as teach. The museum exposed people to science by means of human perception. It provides a form of "educational sightseeing" as well as the understanding of the underlying principles. Its intention was not to replace a science class, but rather to inspire people to learn about science. The exhibits were arranged and structured to allow for free access to any part of the museum. Oppenheimer wanted people to be able to explore the museum and learn at their own pace, following a path that made sense to them and stimulated their curiosity. The idea of having people explore the museum in a way that appeals to everyone was an essential element. Instead of tour guides, fifteen to twenty college students or secondary students, as well as some adults, were employed as "explainers". They demonstrate the exhibits and explain the principles involved all while circulating among visitors, rather than guiding them along. Oppenheimer strove to make learning a fun and enjoyable experience for all.
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https://en.wikipedia.org/wiki?curid=788828
| 151,209
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Helium is lighter than air; larger flow rates are required. It is an inert gas, not reacting with the molten metals. Its thermal conductivity is high. It is not easy to ionize, requiring higher voltage to start the arc. Due to higher ionization potential it produces hotter arc at higher voltage, provides wide deep bead; this is an advantage for aluminium, magnesium, and copper alloys. Other gases are often added. Blends of helium with addition of 5–10% of argon and 2–5% of carbon dioxide ("tri-mix") can be used for welding of stainless steel. Used also for aluminium and other non-ferrous metals, especially for thicker welds. In comparison with argon, helium provides more energy-rich but less stable arc. Helium and carbon dioxide were the first shielding gases used, since the beginning of World War 2. Helium is used as a shield gas in laser welding for carbon dioxide lasers. Helium is more expensive than argon and requires higher flow rates, so despite its advantages it may not be a cost-effective choice for higher-volume production. Pure helium is not used for steel, as it causes an erratic arc and encourages spatter.
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https://en.wikipedia.org/wiki?curid=1924637
| 433,291
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431,209
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Clouds have also been found over the south polar region. While typically covering 1% of Titan's disk, outburst events have been observed in which the cloud cover rapidly expands to as much as 8%. One hypothesis asserts that the southern clouds are formed when heightened levels of sunlight during the Titanean summer generate uplift in the atmosphere, resulting in convection. This explanation is complicated by the fact that cloud formation has been observed not only post–summer solstice but also at mid-spring. Increased methane humidity at the south pole possibly contributes to the rapid increases in cloud size. There had been summer in Titan's southern hemisphere until 2010, when Saturn's orbit, which governs the moon's motion, tilted the northern hemisphere towards the Sun. When the seasons switch, it is expected that ethane will begin to condense over the south pole.
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https://en.wikipedia.org/wiki?curid=16074640
| 430,997
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Despite the word "primary" in its name, PGNCS data was not the main source of navigation information. Tracking data from NASA's Deep Space Network was processed by computers at Mission Control, using least squares algorithms. The position and velocity estimates that resulted were more accurate than those produced by PGNCS. As a result, the astronauts were periodically given state vector updates to enter into the AGC, based on ground data. PGNCS was still essential to maintain spacecraft orientation, to control rockets during maneuvering burns, including lunar landing and take off, and as the prime source of navigation data during planned and unexpected communications outages. PGNCS also provided a check on ground data.
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https://en.wikipedia.org/wiki?curid=954760
| 1,403,519
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275,486
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The South Pacific convergence zone (SPCZ) is a reverse-oriented, or west-northwest to east-southeast aligned, trough extending from the west Pacific warm pool southeastwards towards French Polynesia. It lies just south of the equator during the Southern Hemisphere warm season, but can be more extratropical in nature, especially east of the International Date Line. It is considered the largest and most important piece of the ITCZ, and has the least dependence upon heating from a nearby land mass during the summer than any other portion of the monsoon trough. The southern ITCZ in the southeast Pacific and southern Atlantic, known as the SITCZ, occurs during the Southern Hemisphere fall between 3° and 10° south of the equator east of the 140th meridian west longitude during cool or neutral El Niño–Southern Oscillation (ENSO) patterns. When ENSO reaches its warm phase, otherwise known as El Niño, the tongue of lowered sea surface temperatures due to upwelling off the South American continent disappears, which causes this convergence zone to vanish as well.
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https://en.wikipedia.org/wiki?curid=432961
| 275,337
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Official ACC designated rivalry games include the Virginia–Virginia Tech rivalry and the Virginia–Louisville series. These two rivalries are guaranteed an annual game in all sports, and a home-and-away series in men's and women's basketball. The Cavaliers competed against the Hokies in the "Commonwealth Challenge" and more recently competed in the "Commonwealth Clash", under new rules, for many sports in which they compete head-to-head. The Cavaliers went 2–0 against the Hokies in the "Challenge" and 3–2 in the "Clash" (5–2 overall). Perhaps the two most significant rivalry games played between the Cavaliers and Hokies were both in men's basketball, on March 1, 2007, and January 15, 2019. In the former, the two teams met with identical 10–4 ACC records and the winner would clinch a share of the regular-season conference championship. UVA won the game 69–56 and took their fifth of ten ACC titles. In the latter, No. 4 UVA beat No. 9 Virginia Tech 81–59 in the only meeting between two AP Top 10 teams in the rivalry's history.
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https://en.wikipedia.org/wiki?curid=59801
| 89,213
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1,435,335
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The first classes started on October 9, 1900. Professor Vladimir Nekrasov gave the first lecture on analytic geometry. Among the first professors of the Institute, there were notable scientists: Professor Nikolai Kischner, who discovered the Wolff–Kishner reduction; Professor Theodor Molien, who gave a foundation to higher mathematical education and mathematical research in Siberia; Evgeny Biron, who discovered the phenomena of secondary periodicity; Professor Boris Weinberg, who was an outstanding scientist in physics and glaciologist; Professor Vladimir Obruchev, who was an organizer of the Mining Department and a founder of mining and geological school in Siberia. In the autumn term of 1904/05, Adam Yensh, an outstanding Russian urban planner and a sanitary engineer, gave lectures on construction works and architecture to students of the Construction Engineering Department and on introduction to architecture to students of the Mechanical, Mining and Chemical Engineering Departments. In 1917, Tomsk Technological Institute of Emperor Nicholas II was renamed into Tomsk Technological Institute.
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https://en.wikipedia.org/wiki?curid=4563685
| 1,434,529
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1,722,045
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Sea grasses stabilize sea beds and protect shorelines from erosion by absorbing energy from waves. Shrimp, spiny lobsters, and sea urchins live in and among the grasses and feed on phytoplankton; they in turn feed larger predators such as sharks, rays, barracuda, and king mackerel ("Scomberomorus cavalla"). Due to shallow water and abundant sunlight, Florida Bay hosts communities of coral reefs and sponges, although the majority of the state's reefs are closer to the Florida Keys. Everglades keys that foster mangroves also support nurseries for wading birds such as the Great blue heron ("Ardea herodias"), which was almost wiped out in the Labor Day Hurricane of 1935 (only 146 were counted afterward). After recovering to number more than 2,000, they were further endangered by Hurricane Donna in 1960, which decreased their numbers by 35 to 40 percent.
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https://en.wikipedia.org/wiki?curid=17273354
| 1,721,075
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71,597
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The congressional and media furor over the firing of Admiral Denfeld, as well as the significant use of aircraft carriers in the Korean War, resulted in the Truman administration subsequently ousting both Johnson and Matthews in their respective secretary roles, and in the design and procurement of the subsequent of supercarriers, which were of comparable size to "United States", but with a design geared towards greater multirole use with composite air wings of fighter, attack, reconnaissance, electronic warfare, early warning and antisubmarine-warfare aircraft. At the same time, heavy manned bombers for the SAC were also deemed crucial to national defense and, as a result, the two systems were never again in competition for the same budgetary resources.
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https://en.wikipedia.org/wiki?curid=385077
| 71,570
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207,013
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During a downside regime, a large number of investors who have held positions in riskier assets such as equities or real estate may seek refuge in 'safer' investments such as cash or bonds. This is also known as a flight-to-quality effect and investors tend to exit their positions in riskier assets in large numbers in a short period of time. As a result, during downside regimes, correlations across equities are greater on the downside as opposed to the upside and this may have disastrous effects on the economy. For example, anecdotally, we often read financial news headlines reporting the loss of hundreds of millions of dollars on the stock exchange in a single day; however, we rarely read reports of positive stock market gains of the same magnitude and in the same short time frame.
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https://en.wikipedia.org/wiki?curid=1793003
| 206,906
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James S. Forrester III (born July 13, 1937) is an American cardiologist. Born in Philadelphia, Pennsylvania, he received his medical training at the University of Pennsylvania, UCLA, and Harvard University. During the 1970s through 1990s, his research led to three major advancements in the practice of cardiology. Later in his career, he would return to UCLA, this time as a professor, while simultaneously being the Chief of the Division of Cardiology at Cedars-Sinai Medical Center. Forrester has published hundreds of papers and manuscripts dealing with the subject of cardiology, and is the recipient of numerous awards, including being the second person to ever receive the Lifetime Achievement Award of the American College of Cardiology in 2009.
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https://en.wikipedia.org/wiki?curid=44523992
| 1,819,326
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2,103,323
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The building is a two storied brick and concrete structure of 1000 sq.m.area, with vertical panels of dark face brick separated by lightweight panels containing fenestration and copper sun screens. It has a parapeted form with a simple monopitch roof. The plan comprises a simple rectangular office building with a small central wing containing toilets and service areas on the upper level and air conditioning plant and laboratories on the lower floor (ground) level. It is excavated into the slope so that a broad staircase off the entry drive on its western side accesses the first floor. The only stair connecting the two levels is at one end and not accessed from the foyer, separating the ground floor activities from the public or visitors.
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https://en.wikipedia.org/wiki?curid=57714944
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Markovits proposes a different approach to meritocracy, one where socioeconomic life conveniences are freely distributed to the people who are sufficiently successful at the things they are doing rather than creating an environment of ongoing competition. He promotes the idea that striving for being the best and brightest is a road to personal destruction and the people should be more open to the idea of just being good enough. Restructuring of economic roles, organizations and institutions is desirable in order to include a wider population and hence narrow the increasing inequality gap by questioning the social hegemony of high-profile workers, and intervening with redistribution of earnings, working hours and social identity on behalf of middle class workers.
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https://en.wikipedia.org/wiki?curid=20971
| 102,858
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261,319
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Cell metabolism is necessary for the production of energy for the cell and therefore its survival and includes many pathways. For cellular respiration, once glucose is available, glycolysis occurs within the cytosol of the cell to produce pyruvate. Pyruvate undergoes decarboxylation using the multi-enzyme complex to form acetyl coA which can readily be used in the TCA cycle to produce NADH and FADH. These products are involved in the electron transport chain to ultimately form a proton gradient across the inner mitochondrial membrane. This gradient can then drive the production of ATP and H2O during oxidative phosphorylation. Metabolism in plant cells includes photosynthesis which is simply the exact opposite of respiration as it ultimately produces molecules of glucose.
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https://en.wikipedia.org/wiki?curid=6339
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The school accepts A-levels, the International Baccalaureate Diploma, Irish Leaving Certificate, Scottish Highers, Cambridge Pre-U and the European Baccalaureate as entry qualifications. Both the medical and dental degrees are open to graduate students, with a minimum of a 2:1 required. Applicants must sit the UK Clinical Aptitude Test which is used alongside the UCAS application to determine selection for interview. The school also accepts medical students from the universities of Cambridge, Oxford, the International Medical University Malaysia and St Andrews aiming to complete a 3-year direct clinical entry programme. Students applying to this scheme do not need to apply by 15 October deadline and are not required to take the UKCAT.
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https://en.wikipedia.org/wiki?curid=504928
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Sturtevant accomplished most of his work between 1910 and World War II. These years saw both World War I and the Great Depression. Prior to World War II, universities and research programs operated under private donations; the federal government was not very involved in the funding of scientific research. Much research prior to World War II concerned the chemical nature of heredity. World War II changed the course of science. Focus was shifted away from biology and genetics to nuclear chemistry and physics. During and after World War II, the government became the key financial backer of scientific research, in the hopes that funding basic research would lead to technological advances. In this same time frame, Sturtevant was an outspoken opponent of eugenics and was interested in the effects of the atomic bomb on human populations, due to his previous research on lethal genes. He warned the public of possible harmful genetic effects of nuclear fallout despite supposedly low levels of ionizing radiation.
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https://en.wikipedia.org/wiki?curid=1641423
| 1,406,106
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1,838,833
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Planet Nine can deliver extreme trans-Neptunian objects into orbits roughly perpendicular to the plane of the Solar System. Several objects with high inclinations, greater than 50°, and large semi-major axes, above 250 AU, have been observed. Their high inclination orbits can be generated by a high order secular resonance with Planet Nine involving a linear combination of the orbit's arguments and longitudes of perihelion: Δϖ - 2ω. Low inclination eTNOs can enter this resonance after first reaching low eccentricity orbits. The resonance causes their eccentricities and inclinations to increase, delivering them into perpendicular orbits with low perihelia where they are more readily observed. The orbits then evolve into retrograde orbits with lower eccentricities after which they pass through a second phase of high eccentricity perpendicular orbits before returning to low eccentricity, low inclination orbits. Unlike the Kozai mechanism this resonance causes objects to reach their maximum eccentricities when in nearly perpendicular orbits. In simulations conducted by Batygin and Brown this evolution was relatively common, with 38% of stable objects undergoing it at least once. Saillenfest et al. also observed this behavior in their study of the secular dynamics of eTNOs and noted that it caused the perihelia to fall below 30 AU for objects with semi-major axes greater than 300 AU, and with Planet Nine in an inclined orbit it could occur for objects with semi-major axes as small as 150 AU. In simulations the arguments of perihelion of the objects with roughly perpendicular orbits and reaching low perihelia are clustered near or opposite Planet Nine's and their longitudes of ascending node are clustered around 90° in either direction from Planet Nine's. This is in rough agreement with observations with the differences attributed to distant encounters with the known giant planets. Nine high inclination objects with semi-major axes greater than 250 AU and perihelia beyond Jupiter's orbit are currently known:
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https://en.wikipedia.org/wiki?curid=59389667
| 1,837,784
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Plasma-based ambient ionization is based on an electrical discharge in a flowing gas that produces metastable atoms and molecules and reactive ions. Heat is often used to assist in the desorption of volatile species from the sample. Ions are formed by chemical ionization in the gas phase. A direct analysis in real time source operates by exposing the sample to a dry gas stream (typically helium or nitrogen) that contains long-lived electronically or vibronically excited neutral atoms or molecules (or "metastables"). Excited states are typically formed in the DART source by creating a glow discharge in a chamber through which the gas flows. A similar method called atmospheric solids analysis probe [ASAP] uses the heated gas from ESI or APCI probes to vaporize sample placed on a melting point tube inserted into an ESI/APCI source. Ionization is by APCI.
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https://en.wikipedia.org/wiki?curid=326386
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The difficult portion of their schedule began after claiming the conference title when the Tigers faced their toughest opponent to date, Yale. The Bulldogs followed a similar tactic to earlier opponents by pitting two defenders against Baker but with the increased talent possessed by the Elis their efforts were more effective. While Baker was held goal-less the rest of the team was able to build a two-goal lead in the second half but a flurry of three goals in three minutes by Yale left the Tigers reeling. Kilner managed to tie the game late and push the match into overtime. The tough defensive work done by Yale in regulation appeared to be all the Elis could give and just 12 seconds into the extra frame Patterson scored. The Tigers kept the pressure on, allowing Baker to score his only goal of the night just before the end of the 5-minute session and give Princeton the win.
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https://en.wikipedia.org/wiki?curid=63123921
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In a November 26 scrum with reporters in Washington, DC, President Trump told reporters he had seen and read some of the report but he doesn't believe it. The White House dismissed the NCA4 as "inaccurate". White House spokesperson, Lindsay Walters said that the climate report was "largely based on the most extreme scenario". Walters called for future NCA reports to have a "more transparent and data-driven process that includes fuller information on the range of potential scenarios and outcomes". Katharine Hayhoe, an atmospheric scientist from Texas Tech University said that Walters' claim was "demonstrably false". Hayhoe confirmed that the report "considers all scenarios, from those where we go carbon negative before end of century to those where carbon emissions continue to rise".
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https://en.wikipedia.org/wiki?curid=59146390
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Active learning is "a method of learning in which students are actively or experientially involved in the learning process and where there are different levels of active learning, depending on student involvement." states that "students participate [in active learning] when they are doing something besides passively listening." According to Hanson and Moser (2003) using active teaching techniques in the classroom create better academic outcomes for students. Scheyvens, Griffin, Jocoy, Liu, & Bradford (2008) further noted that “by utilizing learning strategies that can include small-group work, role-play and simulations, data collection and analysis, active learning is purported to increase student interest and motivation and to build students ‘critical thinking, problem-solving and social skills”. In a report from the Association for the Study of Higher Education (ASHE), authors discuss a variety of methodologies for promoting active learning. They cite literature that indicates students must do more than just listen in order to learn. They must read, write, discuss, and be engaged in solving problems. This process relates to the three learning domains referred to as knowledge, skills and attitudes (KSA). This taxonomy of learning behaviors can be thought of as "the goals of the learning process." In particular, students must engage in such higher-order thinking tasks as analysis, synthesis, and evaluation.
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https://en.wikipedia.org/wiki?curid=445239
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There are many forms of lexical–gustatory synesthesia and the various taste sensations linked to the neurological condition vary widely from synesthete to synesthete. Examples of many well-known synesthetic taste experiences are recorded in case studies with singular participants that demonstrate the variability of the condition. In one case, PS is a patient that has taste experiences that happen in her head and not her mouth. Her tastes usually have both texture and temperature associated with the sensation. Some forms of lexical–gustatory synesthesia are triggered by thinking of the word's meaning, rather than its sound or spelling. Others are triggered by hearing or reading an inducer word. In many forms, more well-known words and words used with a higher frequency are more likely to have a strong taste association The phonological roots associated with this form of synesthesia drive the current research on lexical–gustatory synesthesia to determine which parts of the brain are active in synesthetes causing the neurological cross-talk condition and how the findings may relate to neurologically normal persons.
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https://en.wikipedia.org/wiki?curid=6541938
| 1,033,783
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The amino acids with the highest frequency in LCRs are glycine and alanine, with their respective codons GGC and GCC being the most frequent, as well as complementary. In eukaryotes and more specifically in chordates (such as human, mouse, chicken, zebrafish and sea squirt), alanine- and glycine-rich LCRs are over-represented in recently formed LCRs and probably are better tolerated by the cell. Intriguingly, it has also been suggested that they represent the very first two amino acids and codons of the early genetic code. Thus, these two codons and their respective amino acids must have been constituents of the earliest oligopeptides, with a length of 10–55 amino acids and very low complexity. Based on several different criteria and sources of data, Higgs and Pudritz suggest G, A, D, E, V, S, P, I, L, T as the early amino acids of the genetic code. Trifonov's work largely agrees with this categorization and proposes that the early amino acids in chronological order are G, A, D, V, S, P, E, L, T, R. An evolutionary analysis observed that many of the amino acids of the suggested very early genetic code (with the exception of the hydrophobic ones) are significantly enriched in bacterial LCRs. Most of the later additions to the genetic code are significantly under-represented in bacterial LCRs. They thus hypothesize and propose that, in a cell-free environment, the early genetic code may have also produced low complexity oligo-peptides from valine and leucine. However, later on, within a more complex cellular environment, these highly hydrophobic LCRs became inappropriate or even toxic from a protein interaction perspective and have been selected against ever since. In addition, they further hypothesize that the very early protopeptides did not have a nucleic acid binding role, because DNA and RNA-binding LCRs are highly enriched in glycine, arginine and lysine, however, arginine and lysine are not among the amino acids of the proposed early genetic code.
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https://en.wikipedia.org/wiki?curid=60027018
| 1,682,073
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In the 1920s, Otto Loewi determined the biomechanical mechanism for the effects of physostigmine on the body. Loewi was studying how actions that we now consider to be controlled by the parasympathetic nervous system, were directed by chemicals. During his studies, Loewi discovered acetylcholine and that physostigmine acted by preventing acetylcholine inhibition. In 1936, Loewi was awarded the Nobel Prize for his work on discovering acetylcholine and biological chemical transmitters. More important discoveries surrounding physostigmine were made at the University of Edinburgh in 1925. Edgar Stedman and George Barger determined the structure of physostigmine using a method called chemical degradation. In 1935 Percy Lavon Julian was later the first to synthesize physostigmine. English scientist Robert Robinson was also working on the synthesis of physostigmine, but surprisingly Julian, a relatively unknown scientist at the time, was the successful one.
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https://en.wikipedia.org/wiki?curid=743397
| 950,063
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Mild to moderate gastrointestinal side effects (such as nausea, cramping, bloating, and abdominal discomfort) are common after ESG (reported in over 70% of patients), but these are predictable, temporary, and can be managed with medications. Most will resolve within one week after ESG. Due to the minimally invasive nature of ESG, serious complications are rare. These include pain or nausea requiring hospitalization (1.08%); upper gastrointestinal tract bleeding (0.56%); peri-gastric leak or infected fluid collection (0.48%); pulmonary embolism (0.06%); perforation (0.06%). Similar rates of serious adverse events were reported in the multicenter, randomized controlled MERIT study. No deaths have been observed in the published ESG literature.
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https://en.wikipedia.org/wiki?curid=58563702
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As discussed below, there are several context-dependent ways of defining the expected value. The simplest and original definition deals with the case of finitely many possible outcomes, such as in the flip of a coin. With the theory of infinite series, this can be extended to the case of countably many possible outcomes. It is also very common to consider the distinct case of random variables dictated by (piecewise-)continuous probability density functions, as these arise in many natural contexts. All of these specific definitions may be viewed as special cases of the general definition based upon the mathematical tools of measure theory and Lebesgue integration, which provide these different contexts with an axiomatic foundation and common language.
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https://en.wikipedia.org/wiki?curid=9653
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In his book "Science, Faith and Society" (1946), Polanyi set out his opposition to a positivist account of science, noting that it ignores the role personal commitments play in the practice of science. Polanyi gave the Gifford Lectures in 1951–52 at Aberdeen, and a revised version of his lectures were later published as "Personal Knowledge" (1958). In this book Polanyi claims that all knowledge claims (including those that derive from rules) rely on personal judgments. He denies that a scientific method can yield truth mechanically. All knowing, no matter how formalised, relies upon commitments. Polanyi argued that the assumptions that underlie critical philosophy are not only false, they undermine the commitments that motivate our highest achievements. He advocates a fiduciary post-critical approach, in which we recognise that we believe more than we can prove, and know more than we can say.
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https://en.wikipedia.org/wiki?curid=19711
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The "Budapest rook" was an invigorating innovation of the 1980s, and gave the gambit new life. However, inconveniences arise from delaying d7–d6 in order to allow the lift: the light-square bishop has to wait a long time to develop, and any attack on the Bc5 is potentially annoying for Black (since it means either closing the sixth rank with ...d6/...b6, abandoning the active a7–g1 diagonal, or blocking the rook when deployed to a7). This, in addition to the risk of awkwardness in the king side (a knight on f5 will fork the Rh6 and the Qh4) and the single-mindedness of Black's plan (with nothing to fall back on if the direct attack is repelled), has made some revisit the old lines, where it is instead the king's rook that is developed to h6. The queen's rook can then be retained on the queenside, and will be well-placed if the b-file opens as a result of Black's Bc5 being exchanged and recaptured with a b6 pawn.
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https://en.wikipedia.org/wiki?curid=1630627
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