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1. Introduction {#sec1} =============== Vision is the most used sense among the five senses and is one of the primary means by which we collect information from our surroundings. Loss of vision, thus, severely compromises the quality of life and has a significant impact on the lives of families and society, as well as...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Allogeneic organ transplantation has emerged as the current best therapeutic option for selected patients with end stage organ failure. Tolerance induction is highly desirable in this population, because long-term immunosuppressive therapy is associated with significant risks for opport...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Developing adhesives functioning in marine environment is a great challenge. Mimicking sessile marine organisms is an efficient way. For example, catechol-based adhesives inspired from mussel have been extensively developed in the last decade^[@CR1],[@CR2]^. However, the performance o...
{ "pile_set_name": "PubMed Central" }
Human is usually sub-fertile in comparison to other mammals; in other words, reproduction process of other mammals is more effective than human. Chromosomal anomalies of early embryos are the major reason for the low fecundity of human per cycle. Most of embryos with major genetic defects may be implanted and it can be...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Increasing temperatures as a result of global climate change have led to shifts in phenology for many species ([@ref-17]; [@ref-44]; [@ref-26]; [@ref-35]), and widespread debate over the consequences of critical interaction mismatches ([@ref-42]; [@ref-16]; [@ref-1]; [@ref-45]). However, not ...
{ "pile_set_name": "PubMed Central" }
Horse racing has been conducted in the state of California since the 1800s and currently represents approximately 9% of flat races held in the United States (US). In the 2010-2011 fiscal year, California had 12 racetracks, with 40,070 horse starts and horses vying for almost US\$140 million in purses.^[@bibr4-232596711...
{ "pile_set_name": "PubMed Central" }
![](brjcancer00102-0159.tif "scanned-page"){.615}
{ "pile_set_name": "PubMed Central" }
Introduction {#section1-2151458514548577} ============ Very old patients with a hip fracture often need surgery requiring anesthesia and are presumably at a greater risk of complications. Development of postoperative cognitive dysfunction may be evident and can be a key issue for increased morbidity and delayed functi...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-materials-13-01094} =============== Dental caries in young children may affect their body weight, growth, and quality of life \[[@B1-materials-13-01094]\]. If the caries remain untreated, they can rapidly progress into cavitation, involve dental pulp, and lead to dental infection or dangerous fa...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper and its Supporting Information files. Introduction {#sec001} ============ Nowadays is not uncommon to find headlines in the media where it is stated that 3D printing is a technology called to change our lives in the near future \[[@pone.0169832.ref001], [@pone.0169832.ref002]\]....
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== *Aristolochiae Fructus* (AF), the dry-ripe fruit of perennial herb *Aristolochia contorta* BGE. or *Aristolochia debilis* SIEB. *et* ZUCC., has been used in China for thousands of years as an anti-tussive and expectorant drug with significant curative effects \[[@CR1]\]. The crude AF is b...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Regular physical activity is significant in the prevention and treatment of physical and mental health conditions including cardiovascular disease, diabetes, hypertension, osteoporosis, some cancers, anxiety and depression \[[@CR1]\]. Worldwide, the prevalence of physical activity at reco...
{ "pile_set_name": "PubMed Central" }
This article is an overview of the collection. No specific database was used to develop it. Introduction {#sec001} ============ Mitigating the effects of climate change is a major global challenge. In November 2015, the 21^st^ Conference of the Parties (COP 21) of the United Nations Framework Convention on Climate Ch...
{ "pile_set_name": "PubMed Central" }
![](brjcancer00026-0058.tif "scanned-page"){.1564} ![](brjcancer00026-0059.tif "scanned-page"){.1565} ![](brjcancer00026-0060.tif "scanned-page"){.1566} ![](brjcancer00026-0061.tif "scanned-page"){.1567} ![](brjcancer00026-0062.tif "scanned-page"){.1568} ![](brjcancer00026-0063.tif "scanned-page"){.1569}
{ "pile_set_name": "PubMed Central" }
Introduction {#sec001} ============ There is growing evidence that the sugar N-acetylglucosamine (GlcNAc) plays diverse roles in cell signaling pathways that impact the virulence properties of microbes and host cells. GlcNAc is already well known as a ubiquitous structural component at the cell surface that forms part...
{ "pile_set_name": "PubMed Central" }
The fifth author\'s name is missing the middle initial. The correct name is: Robert H. Singer. The correct citation is: Chou Y-y, Heaton NS, Gao Q, Palese P, Singer RH, et al. (2013) Colocalization of Different Influenza Viral RNA Segments in the Cytoplasm before Viral Budding as Shown by Single-molecule Sensitivity FI...
{ "pile_set_name": "PubMed Central" }
With the 22 December 2008 collapse of a Tennessee Valley Authority (TVA) ash pond in Kingston, Tennessee, and the arrival of the Obama administration the following month, the regulatory ground is shifting in regards to coal combustion waste (CCW), the millions of tons of waste left over each year from burning coal for ...
{ "pile_set_name": "PubMed Central" }
Data are available upon request from dbGaP to researchers who meet the criteria for access to data (accession numbers: phs000851.v1.p1, phs000812.v1.p1, phs000383.v1.p1, phs000147.v3.p1, and phs000799.v1.p1). African American Breast Cancer Consortium (AABC) data was provided via dbGaP project phs000851.v1.p1: <https://...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1-1} ============ Ependymomas are the most common intramedullary tumors in adults. They account for 60% of all intramedullary tumors. Most commonly they arise from cells lining of the central canal within the spinal cord and present as intramedullary tumor.\[[@ref1]\] Intradural extramedullary (IDEM)...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#sec1} ============ During the last two years, a significative number of papers have been published on the field of infection in onco-hematological patients. To choose the most relevant ten papers constitutes a challenge in several ways. On one hand, the subjectivity of the author is unavoidable; an appa...
{ "pile_set_name": "PubMed Central" }
We extracted tau filaments from the brains of three individuals with a neuropathologically confirmed diagnosis of CBD. Abundant neuronal inclusions and astrocytic plaques were stained by antibodies specific for 4R tau ([Figure 1a-c](#F1){ref-type="fig"}) and for hyperphosphorylated tau ([Figure 1e](#F1){ref-type="fig"}...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1} ============ The first case of COVID-19 infection in Italy was confirmed during the night of February 20th, 2020, in a small town of Lombardy, a district in Northern Italy with 10 million inhabitants. In the week that followed, several nearby towns experienced a very rapid increase in the number o...
{ "pile_set_name": "PubMed Central" }
Inflammatory arthritis caused by autoimmune disorders is a chronic, progressive set of diseases with worldwide prevalence.[@r1] Rheumatoid arthritis (RA), one such type of inflammatory arthritis, has symptoms of stiffness, pain, and swelling of the joints. In addition, RA synovium shows hypoxia, neoangiogenesis, and sy...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ It is now well-established that the microbiota contributes significantly to human health and disease. So far, microbiota investigations have been mainly focused on bacteria, but also archea, viruses, and micro-eukaryotes such as protozoa and fungi are part of human-associated microbial ...
{ "pile_set_name": "PubMed Central" }
Introduction {#S1} ============ *Salmonella enterica* serovar Typhimurium has been shown to possess anti-tumor activity in a mouse model, the capability to selectively amplify within tumors, and express therapeutic proteins [@R1], [@R2]. Reports have indicated that *S*. Typhimurium selectively infects and preferential...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Let $\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepack...
{ "pile_set_name": "PubMed Central" }
Sarcoma (Src) homology 2 (SH2) B adaptor protein 1 (SH2B1) is a member of a family of scaffold proteins implicated in signaling downstream of a variety of receptor tyrosine kinases and cytokine receptors that bind to Janus kinases (JAKs). These include receptors for leptin, insulin, GH, IGF-I, nerve growth factor (NGF)...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Bladder cancer (BC) remains a commonly diagnosed urological malignancy with a high recurrence rate. The standard treatment for managing BC is a complete transurethral resection of the bladder tumor (TURBT). Intravesical instillation with chemotherapeutic agents or bacillus Calmette-Gu...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== In spite of the rapid increase of research findings, a corresponding translation of available relevant knowledge into practice does not occur \[[@CR1]\]. Over the past two decades, numerous efforts to bridge the know-do gap, also referred to as efforts to increase knowledge translation (K...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ [*S. aureus*](http://dx.doi.org/10.1601/nm.6874) is a bacterial species which has been isolated from diverse hosts including humans, other mammals and birds \[[@CR1], [@CR2]\]. In humans, it is persistently present in the nares of approximately 20 % of all individuals and intermittent...
{ "pile_set_name": "PubMed Central" }
In the December 2011 issue of *Diabetes*, Kim et al. ([@B1]) reported that 4-1BB (CD137/TNFRSF9) deficiency protected against high-fat diet--induced obesity, glucose intolerance, and fatty liver disease. They found that 4-1BB deficiency reduced number and activation of macrophages/CD8^+^ T cells/Th1 cells into adipose ...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Malaria is one of the oldest documented human diseases, yet it is one of the most prevalent human infectious diseases even today. According to the latest estimates from WHO, there were 214 million new malaria cases and an estimated 4, 38,000 malaria deaths in 2015 ([@B127]). Malaria is caused...
{ "pile_set_name": "PubMed Central" }
Dear Editor, We read the article Single stage surgery for Blepharophimosis syndrome' by Bhattacharjee, *et al*.\[[@ref1]\] We do agree with the authors that single stage surgery is a useful approach, but it can't be practiced as a blanket treatment. Although the minimum age of patients in this article was 6 years and...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Maintaining critical infrastructure resilience to natural hazards during the novel coronavirus outbreak (COVID-19) is crucial yet challenging. The US Department of Homeland Security (DHS), understands critical infrastructures as infrastructure sectors such as water supply, public heal...
{ "pile_set_name": "PubMed Central" }
Déficit en glucose-6-phosphate déshydrogénase {#sec0005} ============================================= **À la suite d'un épisode hémolytique, on m'a diagnostiqué un déficit en glucose-6-phosphate déshydrogénase (G6PD). Quelles sont les précautions à prendre ?** **La réponse du pharmacien** Le déficit en glucose-6-ph...
{ "pile_set_name": "PubMed Central" }
On June 6, 2018, at 1:30 p.m., the New York City Department of Health and Mental Hygiene was notified of three related women who had arrived at a hospital 4 hours earlier for evaluation for acute nausea, dizziness, blurred vision, slurred speech, ptosis, thick-feeling tongue, and shortness of breath. Two patients devel...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Furin is a crucial member of Ca^+2^-dependent mammalian subtilases collectively known as **Proprotein Convertases (PCs)** or **Proprotein Convertase Subtilisin/Kexins (PCSKs)**. This membrane bound type 1 protease is responsible for tissue-specific endoproteolytic cleavage of a large va...
{ "pile_set_name": "PubMed Central" }
Key Points {#FPar1} ========== Amantadine absorption is not affected by renal impairmentIncreased renal impairment is associated with decreased amantadine clearanceIt is recommended that individuals with renal impairment taking 129 mg amantadine ER adhere to the proposed dosing schedule Introduction {#Sec1} =========...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Intensively managed short-rotation hardwood plantations in the southern United States offer opportunities to meet a diversity of management objectives that cannot be met through natural stand management alone ( [@R40] ; [@R41] ). Initial interest in hardwood plantation forestry coincided with...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Sickle-cell disease anemia is an inherited hemoglobin disorder characterized by defective hemoglobin synthesis with production of an abnormal form of hemoglobin, known as sickle hemoglobin (Hb S).^[@B1]^ HbS is caused by mutation in β-globin gene in which the 17^th^ nucleotide is changed fro...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== As the population ages, the prevalence of AD dramatically increases and poses tremendous impact on the provision of health care and economy, apart from its devastating social implications. According to Ziegler-Graham et al. \[[@B1]\], if it was possible to delay the onset of AD ...
{ "pile_set_name": "PubMed Central" }
Acute optic nerve injury due to nonarteritic anterior ischemic optic neuropathy (NAION) typically causes significant visual field defects and reduced visual acuity (VA), which almost always is permanent. In recent years imaging methods, such as optical coherence tomography and scanning laser polarimetry, have been used...
{ "pile_set_name": "PubMed Central" }
![](brforeignmcrev72751-0055){#sp1 .339} ![](brforeignmcrev72751-0056){#sp2 .340} ![](brforeignmcrev72751-0057){#sp3 .341} ![](brforeignmcrev72751-0058){#sp4 .342} ![](brforeignmcrev72751-0059){#sp5 .343} ![](brforeignmcrev72751-0060){#sp6 .344} ![](brforeignmcrev72751-0061){#sp7 .345} ![](brforeignmcrev72751-00...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the paper. Introduction {#sec005} ============ Clinical studies investigating the prevalence and severity of depression associated with dementia have found that depression or depressive symptoms are among the most common behavioral and psychological symptoms of Alzheimer's disease (AD) an...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Dendritic cells (DCs) are the main antigen presenting cells for initiating primary immune responses [@pbio.1001759-Ahlers1]. DCs patrol the bloodstream and tissues to sense danger signals from bacteria, viruses, or toxins. After exposure to such stimuli they undergo an extensive maturat...
{ "pile_set_name": "PubMed Central" }
As nanotechnology becomes more widespread, manufactured nanomaterials are latently discharged into the environment. The potential environmental risks to human health have been the subject of increasing attention[@b1][@b2][@b3][@b4][@b5][@b6][@b7]. Titanium dioxide nanoparticles (TiO~2~-NPs) have been considered of low ...
{ "pile_set_name": "PubMed Central" }
Background ========== The incidence of breast cancer in China has been progressively increasing with the development of the Chinese economy. Indeed, the incidence was estimated to be 272 400 in 2015, with a mortality of 70 700 \[[@b1-medscimonit-24-2465]\]. Breast cancer is especially prevalent in developed cities, su...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ In the last few decades ethnobotanical research has reflected multifarious medicinal properties of plants including analgesic (Wirth et al., [@B65]), anti-inflammatory (Kumar et al., [@B39]), anti-rheumatic (Kaur et al., [@B32]), anti-cancer (Fridlender et al., [@B15]), and anti-depress...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Hydrogen peroxide (H~2~O~2~) is a thermally instable chemical agent with high oxidative power, which dissociates into free radicals and other reactive oxygen species (ROS), such as hydroxyl radicals (OH^−^), singlet oxygen (O^2−^), and superoxide anion (O~2~ ^−^) \[[@B1]\]. This...
{ "pile_set_name": "PubMed Central" }
For the ristocetin structure described in the article by Nahoum *et al*. (2009[@bb1]), a disordered arabinose sugar was incorrectly modelled in the pyranose form and an incorrect stereochemistry was used for the ristosamine sugar. These errors have been corrected and the structure has been rerefined, yielding *R* ~crys...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Modic changes (MCs) are signal intensity changes of vertebral bone marrow adjacent to the endplates of degenerated intervertebral discs on magnetic resonance images (MRI). Modic et al.[@B13] first classified MCs into three types based on MRI findings and histological correlations. Modic type ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== The tree shrew (*Tupaia belangeri*) is a small mammal similar in appearance to squirrel, widely distributed in South Asia, Southeast Asia and Southwest China \[[@CR1]\]. Due to several specific characteristics, such as small adult body size, short reproductive and life cycle, low cost of ...
{ "pile_set_name": "PubMed Central" }
In early May 2011, an unprecedented large outbreak of hemolytic-uremic syndrome (HUS) and hemorrhagic colitis (HC) started in Germany and subsequently spread throughout Europe and North America. Nearly 4,000 individuals were affected, including almost 900 cases of HUS and 54 deaths[@b1]. The outbreak was linked to the ...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1} =============== Undiscovered knowledge of mechanisms regulating stem cell niche metabolism during quiescence, proliferation and differentiation is a current limitation to the progression of basic cell biology, tissue engineering and regenerative medicine. Various metabolic and mitochondrial fun...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-ijerph-17-01207} =============== As science and technology continue to develop, consumer goods, including home appliances, household goods, and foods, are becoming increasingly specialized. The problem is that consumer goods containing heavy metals, residual pesticides, food additives, or traces...
{ "pile_set_name": "PubMed Central" }
Genome-wide association studies (GWAS) have revolutionized complex disease genetics. In just the last few years, GWAS have been used to identify hundreds of variants affecting a diverse range of common diseases and disease associated quantitative traits (for a summary, see <http://www.genome.gov/gwastudies/>). Although...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Drugs may interact with numerous molecules in the human body. Approximately 35% of known drugs or drug leads present multi-target activity [@pone.0083922-Xie1]. Even when a drug is claimed to have high selectivity, it probably binds to proteins that are not identified as targets. Such u...
{ "pile_set_name": "PubMed Central" }
Background ========== Exercise and training have indisputably demonstrated impressive potential in inducing physiological adaptations in both the cardiovascular and muscular systems \[[@B1]-[@B4]\]. Nonetheless, researchers still strive to elucidate the most efficient ways to exercise for certain adaptations, such as ...
{ "pile_set_name": "PubMed Central" }
Chemical context   {#sec1} ================== The parent ligand 2-(4′,4′-dimethyl-2′-oxazolin­yl)aniline (H~2~-**L1**), easily prepared in high yield using established procedures (Gossage, 2009[@bb23]), has been used as a precursor to biologically active quinilones \[see, for example, Hong *et al.* (2018[@bb26])\] and...
{ "pile_set_name": "PubMed Central" }
Progeroid syndromes are rare genetic diseases characterized by reduced lifespan and by premature appearance of symptoms related to physiological aging. For a majority of progeroid syndromes the causative mutation has been identified pointing to the role of DNA function and of lamins in these diseases. We report here on...
{ "pile_set_name": "PubMed Central" }
The Veterans Health Administration (VHA) has transformed its approach to health care to one that is personalized, proactive, and patient-centered with the goal of helping Veterans achieve their greatest possible health and well-being.^[@bibr1-2515690X18801581]^ As a part of this transformation, the VHA has developed ex...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the manuscript and its Supporting Information files. Introduction {#sec001} ============ Tuberculosis (TB) is a major infectious disease that causes 1.3 million deaths per year worldwide \[[@pone.0213536.ref001]\]. The reactivation risk of the latent TB in an immunosuppressed individual a...
{ "pile_set_name": "PubMed Central" }
All relevant data are within the manuscript and its Supporting Information files. Introduction {#sec001} ============ High-throughput screening (HTS) is a fundamental step in the hierarchical and long drug development process. Discovering and developing a drug starts with libraries consisting of thousands of chemical...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ The cell envelope is crucial for growth and virulence of pathogenic mycobacteria like *M. tuberculosis*^[@CR1]^ and is a major contributor to resistance against common antibiotics^[@CR2]^. Its main component is the mycolyl-arabinogalactan-peptidoglycan complex, which consists of pepti...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Breast cancer is the most common forms of hereditary cancer worldwide. It is an important cause of morbidity and mortality. Based on the statistics released by the American Cancer Society in 2007, it is the second lethal cancer in women after lung cancer ([@b1-ijph-40-57]). Germ-line mutation...
{ "pile_set_name": "PubMed Central" }
The Council of Scientific and Industrial Research has carried out an investigation about several publications by this group in order to evaluate concerns raised about the authenticity of the data. The investigation committee at the Council of Scientific and Industrial Research has concluded that there are no data avai...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Synthetic lethality is traditionally defined as a type of genetic interaction in which the simultaneous mutation of two genes leads to cell death, while mutation of only one of them does not.^[@CR1],[@CR2]^ Recently, the concept of synthetic lethality has been extended to include chem...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Correlates of age-related cerebral small vessel disease, such as white matter lesions and lacunes are common ([@awr252-B29]), can progress rapidly ([@awr252-B48]) and are associated with cognitive impairment ([@awr252-B10]; [@awr252-B32]) to dementia ([@awr252-B37]; [@awr252-B52]), gait distu...
{ "pile_set_name": "PubMed Central" }
Background ========== Musculoskeletal conditions are a common reason for presenting to primary care where it represents up to 18% of a general practitioner\'s (GP) workload \[[@B1]\]. Although healthcare systems vary between countries, primary care is generally regarded as the point of first contact for musculoskeleta...
{ "pile_set_name": "PubMed Central" }
1.. Introduction ================ The search for pharmacological properties from natural products has led to the discovery of pharmacologically active substances, with important applications both in the experimental field and identification of active principles with therapeutic interest \[[@b1-marinedrugs-09-00307]--[...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== Perivascular Epithelioid Cell Tumor (PEComa) is a rare mesenchymal neoplasm which is thought to originate from perivascular epithelioid cells showing both melanocytic and myogenic differentiation \[[@CR1]\]. Although this tumor was first described as a benign lung tumor in 1971 by Liebow ...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== It is widely accepted that a rise in the availability of intracellular Ca^2+^, through the up-regulation of calcium influx and release pathways, underpins the development of forceful uterine contractions during labour \[[@CR1]--[@CR3]\]. However, there is little understanding of how chang...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Large polymer drugs typically have a high density of binding sites and thus a large capacity to absorb their target species ([@CR1]). As large insoluble particles (\>10 μm), they are excreted, along with the bound material, rather than being digested and absorbed into the blood stream...
{ "pile_set_name": "PubMed Central" }
Editor: Jason Kahn. Introduction {#sec1} ============ The hierarchical organization of eukaryotic DNA into nucleosomes and higher-order structures has profound implications for DNA accessibility by regulatory factors. Nucleosome arrays present a barrier to DNA-binding proteins in two ways. First, the DNA fragments wr...
{ "pile_set_name": "PubMed Central" }
![](yjbm00086-0020.tif "scanned-page"){.97} ![](yjbm00086-0021.tif "scanned-page"){.98} ![](yjbm00086-0022.tif "scanned-page"){.99} ![](yjbm00086-0023.tif "scanned-page"){.100} ![](yjbm00086-0024.tif "scanned-page"){.101} ![](yjbm00086-0025.tif "scanned-page"){.102} ![](yjbm00086-0026.tif "scanned-page"){.103} !...
{ "pile_set_name": "PubMed Central" }
Data on risk factors for influenza-associated severe disease are key to guide targeted influenza vaccination. This is particularly important in resource-limited settings where influenza vaccine availability is limited. However, in 2012 the World Health Organization (WHO) Strategic Advisory Group of Experts on Immuniza...
{ "pile_set_name": "PubMed Central" }
Introduction {#sec1} ============ The extremely diverse antibody and T cell repertoire exists as a result of early VDJ (variable (V), diversity (D) and joining (J)) recombination events, creating an enormous possibility of different sequences ([@ref1]). Any given antibody or T cell may protect from an infection or may...
{ "pile_set_name": "PubMed Central" }
Introduction ============ Receptor activator of nuclear factor (NF)-κB ligand (RANKL) and its cognate receptor RANK were initially characterized as essential factors for osteoclastogenesis (reviewed in Lacey *et al.*[@b1]). Mice in which either the *RANK* or *RANKL* genes are ablated exhibit severe osteopetrosis and a...
{ "pile_set_name": "PubMed Central" }
It has been estimated that 1.6 million to 3.8 million sports-related concussions occur each year in the United States, including those that go unreported.^[@bibr25-2325967120913020]^ The American Medical Society for Sports Medicine has defined concussion as "a traumatically induced transient disturbance of brain functi...
{ "pile_set_name": "PubMed Central" }
Background {#Sec1} ========== The productions of functional foods containing probiotic bacteria such as lactobacilli are gaining high significance throughout the world. These bacteria enhance the microbial safety and offer organoleptic, technological, nutritional, and health benefits to the consumers. As a consequence...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-foods-09-00084} =============== Infant formula (IF) powders are dehydrated emulsions consisting of protein, fat carbohydrate, vitamins, and minerals necessary to nourish infants in the absence of breast milk. As an infant grows and solid foods are introduced, complimentary follow-on (FO) formula...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-children-05-00070} =============== Childhood food allergy prevalence is estimated at 8% in the United States and has risen at a rapid rate over the past two decades \[[@B1-children-05-00070],[@B2-children-05-00070]\]. Food allergy has a high economic cost, including direct medical costs and indi...
{ "pile_set_name": "PubMed Central" }
Background ========== Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased platelet destruction and suboptimal platelet production, resulting in a decreased number of circulating platelets and increased incidence of bleeding \[[@B1],[@B2]\]. The most common symptoms of ITP are mild bruisi...
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ The importance of intraoperative safety for both patients and surgeons and the concept of "tailored surgery" have become one of the main topics in surgical research over the past few years \[[@CR1]\]. Patient-centered preoperative planning is required to achieve accurate knowledge of ...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ Curative-intent aggressive treatments for locoregionally advanced (stage III or IV) head and neck squamous cell carcinoma (HNSCC) including combined modality approaches (surgery, radiotherapy \[RT\], and/or chemotherapy \[CT\]) are generally required to optimize the likelihood of long-term co...
{ "pile_set_name": "PubMed Central" }
1. Introduction {#sec1-genes-08-00318} =============== Whole genome duplications (WGDs), the events resulting in polyploid organisms' appearance, are not very common among chordate animals (in contrast to plants, for instance) \[[@B1-genes-08-00318]\], but they played a substantial role in early vertebrate evolution \...
{ "pile_set_name": "PubMed Central" }
{ "pile_set_name": "PubMed Central" }
Introduction {#Sec1} ============ Electric double-layer capacitors (EDLCs), also known as supercapacitors or ultracapacitors, rely on the rapid and reversible adsorption/desorption of ions at the electrode--electrolyte interface for charge storage. This kind of charge storage mechanism offers EDLCs several desirable p...
{ "pile_set_name": "PubMed Central" }
Introduction {#S1} ============ The reconstruction of craniofacial tissues embraces a broad set of biological and clinical interests. Whether the particular biological or clinical concern involves bone, cartilage, salivary glands, skin and mucosa, muscle or nerve, the fundamental principles and challenges of tissue re...
{ "pile_set_name": "PubMed Central" }
Background ========== The aim of his study is to test--retest the EuroPrevall quality of life questionnaire (QoLQ), and determine the influence of nutritional instructions, access to epinephrine, and the presence of atopic dermatitis on quality of life of patients with food allergy. Furthermore, we assessed whether pa...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION {#s1} ============ Foreign bodies accidentally or intentionally ingested usually pass the entire gut without incidents. Sharp objects such as a toothpick sometimes fail to pass and may cause a perforation. This type of unusual injury may cause significant morbidity and mortality. The possible complication...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Biomarkers in breast cancer contribute essentially to adjuvant and preoperative therapy assessment. Additionally to conventional prognostic factors as tumor-size, grading or nodal status, treatment decisions include the three established predictive biomarkers as estrogen (ER) and proges...
{ "pile_set_name": "PubMed Central" }
INTRODUCTION ============ TropGeneDB is an information system initially developed by CIRAD (French Agricultural Research Centre for International Development) to manage various kinds of data on tropical crops ([@gks1105-B1]). TropGeneDB can record crop information on:molecular markers, quantitative trait loci (QTLs),...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Flavonoids are known to be produced by all terrestrial plants. They comprise a large group of natural compounds deriving from the phenylpropanoid metabolism, which has evolved in plants to produce a large number of inter-related flavonoid structures (Figure [1](#F1){ref-type="fig"}). Va...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide, and the costs of invasive and noninvasive diagnostic methods, which are performed to identify the presence and severity of CAD, are increasing dramatically. The severity of CAD, which can be analyzed ...
{ "pile_set_name": "PubMed Central" }
1. INTRODUCTION {#acm212113-sec-0001} =============== Hepatocellular carcinoma (HCC) is a highly prevalent and lethal neoplasia,[1](#acm212113-bib-0001){ref-type="ref"} comprising the majority of primary liver cancers worldwide (70--90%). An estimated 782,500 new liver cancer cases and 745,500 deaths occurred worldwid...
{ "pile_set_name": "PubMed Central" }
Introduction {#s1} ============ Cotton (*Gossypium hirsutum*) is one of the most important economic crops in the world, but productivity is constrained by various biotic and abiotic stresses ([@CIT0042]). Fungal diseases such as Fusarium and Verticillium wilt pose the largest threat to cotton ([@CIT0050]). These patho...
{ "pile_set_name": "PubMed Central" }
Background {#s1} ========== Nivolumab, the focus of this case report, has been shown to have a significant overall survival benefit compared to docetaxel in the setting of second-line treatment of non-small cell lung cancer (NSCLC). The toxicity profile of nivolumab is also better than that of docetaxel, although the ...
{ "pile_set_name": "PubMed Central" }
In the article titled "Obesity is the Most Important Factor for Gender Inequality in Type 2 Diabetes Incidence in an Iranian Population", published as allocation ID 215 in Volume 10 of International Journal of Preventive Medicine,\[[@ref1]\] the name of the Second author is written incorrectly as "Mohammad Hassan Hashe...
{ "pile_set_name": "PubMed Central" }