smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
NS(=O)(=O)C=CC1CCO1
NS(=O)(=O)C=CC1CCO1
true
CC(C)(C)CCC1CCC1
C1COC1
163.198
36.6042
-0.4225
3
1
19
69.39
CC(=CC=O)S(=O)(=O)C#C
C#CS(=O)(=O)C(C)=CC=O
false
CCCC(C)C(C)(C)CC
158.178
37.5738
0.0946
3
0
16
51.21
NC(=S)NCCC1CNC1
NC(=S)NCCC1CNC1
true
CC(C)CCCC1CCC1
C1CNC1
159.258
45.7648
-0.5709
2
3
23
50.08
NC(C=C)(C#C)S(O)(=O)=O
C#CC(N)(C=C)S(=O)(=O)O
false
CCC(C)(CC)C(C)(C)C
161.182
37.497
-0.6516
3
2
17
80.39
CN1CC(=CS1(=O)=O)C#C
C#CC1=CS(=O)(=O)N(C)C1
false
CCC1CC(C)C(C)(C)C1
O=S1(=O)C=CCN1
157.194
38.4658
-0.2213
2
0
17
37.38
NN=C1NC=C(CC=C)S1
C=CCc1c[nH]c(=NN)s1
false
CCCC1CCC(CC)C1
N=c1[nH]ccs1
155.226
42.3211
0.5791
3
2
19
54.17
CCN1CC(C)NNC1=S
CCN1CC(C)NNC1=S
true
CCC1CC(C)CCC1C
S=C1NCCNN1
159.258
45.5784
0.0895
2
2
23
27.3
CCC=CN1C=NSC1=O
CCC=Cn1cnsc1=O
false
CCCCC1CCCC1C
O=c1[nH]cns1
156.21
41.995
1.1855
4
0
18
34.89
O=S1(=O)CCC2=C1OCC2
O=S1(=O)CCC2=C1OCC2
true
CC1(C)CCC2CCCC21
O=S1(=O)CCC2=C1OCC2
160.194
35.9988
0.4368
3
0
18
43.37
CCOC=CC1=CC=CS1
CCOC=Cc1cccs1
false
CCCCCC1CCCC1
c1ccsc1
154.234
44.979
2.7553
2
0
20
9.23
CN1NC(CNC1=S)C=O
CN1NC(C=O)CNC1=S
false
CCC1CCC(C)C(C)C1
S=C1NCCNN1
159.214
41.3514
-1.1216
3
2
19
44.37
CNC1CC(=C)OS1(=O)=O
C=C1CC(NC)S(=O)(=O)O1
false
CCC1CC(C)CC1(C)C
C=C1CCS(=O)(=O)O1
163.198
36.6095
-0.2043
4
1
19
55.4
ON1CC2(CC2)NNC1=S
ON1CC2(CC2)NNC1=S
true
CC1CCC2(CC2)CC1C
S=C1NCC2(CC2)NN1
159.214
39.3269
-0.3971
3
3
19
47.53
NCCC(=C)C1=CSN=N1
C=C(CCN)c1csnn1
false
CCCC(C)C1CCCC1
c1csnn1
155.226
42.6144
0.9001
4
1
19
51.8
CC1C2C=C(C)S(=O)(=O)C12
CC1=CC2C(C)C2S1(=O)=O
false
CC1C2CC(C)C(C)(C)C12
O=S1(=O)C=CC2CC21
158.222
39.1188
0.9531
2
0
20
34.14
CC1=C(C)N=C(S1)C=NN
Cc1nc(C=NN)sc1C
false
CCCC1CC(C)C(C)C1
c1cscn1
155.226
43.3694
1.05254
4
1
19
51.27
C=C(C#N)S(=O)(=O)CC#C
C#CCS(=O)(=O)C(=C)C#N
false
CCCC(C)(C)C(C)CC
155.178
37.3728
0.07168
3
0
15
57.93
CC1(C)NCC(=C)S1(=O)=O
C=C1CNC(C)(C)S1(=O)=O
false
CC1CCC(C)(C)C1(C)C
C=C1CNCS1(=O)=O
161.226
40.1415
0.2542
3
1
21
46.17
O=C1SC=CN1OCC#C
C#CCOn1ccsc1=O
false
CCCCC1CCCC1C
O=c1[nH]ccs1
155.178
38.859
-0.0284
4
0
15
31.23
CC1CCNC(=S)N1C=C
C=CN1C(=S)NCCC1C
false
CCC1C(C)CCCC1C
S=C1NCCCN1
156.254
46.7157
1.0986
1
1
22
15.27
NC1=C(N)N=C(CC#N)S1
N#CCc1nc(N)c(N)s1
false
CCCC1CC(C)C(C)C1
c1cscn1
154.198
40.2558
0.37358
5
2
16
88.72
CNCC#CC1=NC=CS1
CNCC#Cc1nccs1
false
CCCCCC1CCCC1
c1cscn1
152.222
42.9187
0.714
3
1
18
24.92
C1OCC(=C1)C1=CN=NS1
C1=C(c2cnns2)COC1
false
C1CCC(C2CCCC2)C1
C1=C(c2cnns2)COC1
154.194
38.705
0.9517
4
0
16
35.01
CC1CCCOS(=O)(=O)N1
CC1CCCOS(=O)(=O)N1
true
CC1CCCCC(C)(C)C1
O=S1(=O)NCCCCO1
165.214
36.7035
0.0197
3
1
21
55.4
S=C1NOC2(CC2)C=CN1
S=C1NC=CC2(CC2)ON1
false
CC1CCCC2(CC1)CC2
S=C1NC=CC2(CC2)ON1
156.21
41.0594
0.442
2
2
18
33.29
CCC(C)=CNC(=S)NN
CCC(C)=CNC(=S)NN
true
CCC(C)CCC(C)CC
159.258
47.1048
0.638
2
3
23
50.08
NCC1=C2NCCC2=NS1
NCc1snc2c1NCC2
false
CCC1CCC2CCCC12
c1snc2c1NCC2
155.226
42.1991
0.5698
4
2
19
50.94
CC1CS(=O)(=O)CCC1=C
C=C1CCS(=O)(=O)CC1C
false
CC1CCC(C)(C)CC1C
C=C1CCS(=O)(=O)CC1
160.238
41.5748
0.9972
2
0
22
34.14
CNC1CC(=N)NS1(=O)=O
CNC1CC(=N)NS1(=O)=O
true
CCC1CC(C)CC1(C)C
N=C1CCS(=O)(=O)N1
163.202
37.2469
-1.16773
4
3
19
82.05
CN1C2C=NOC2S1(=O)=O
CN1C2C=NOC2S1(=O)=O
true
CC1C2CCCC2C1(C)C
O=S1(=O)NC2C=NOC21
162.17
33.8358
-1.0277
4
0
16
58.97
CC1=CS(=O)(=O)CC1C=C
C=CC1CS(=O)(=O)C=C1C
false
CCC1CC(C)(C)CC1C
O=S1(=O)C=CCC1
158.222
41.2308
1.1208
2
0
20
34.14
NCC=C1CNS(=O)(=O)N1
NCC=C1CNS(=O)(=O)N1
true
CCCC1CCC(C)(C)C1
C=C1CNS(=O)(=O)N1
163.202
37.1956
-1.7334
3
3
19
84.22
CS(=O)(=O)C=CC#CC#N
CS(=O)(=O)C=CC#CC#N
true
CCCCCCC(C)(C)C
155.178
37.3728
0.07168
3
0
15
57.93
CC#CC1=NSN=C1C#N
CC#Cc1nsnc1C#N
false
CCCC1CCCC1CC
c1cnsn1
149.178
37.176
0.78118
4
0
13
49.57
CC1=CCCCS(=O)(=O)O1
CC1=CCCCS(=O)(=O)O1
true
CC1CCCCC(C)(C)C1
O=S1(=O)CCCC=CO1
162.21
37.8628
1.0304
3
0
20
43.37
CC12NCCC1OS2(=O)=O
CC12NCCC1OS2(=O)=O
true
CC1(C)CC2CCCC21C
O=S1(=O)OC2CCNC21
163.198
34.8175
-0.5755
4
1
19
55.4
CC1OC1C=CS(C)(=O)=O
CC1OC1C=CS(C)(=O)=O
true
CC1CC1CCC(C)(C)C
C1CO1
162.21
38.3188
0.332
3
0
20
46.67
CCC1=NOCS(=O)(=O)N1
CCC1=NOCS(=O)(=O)N1
true
CCC1CCCC(C)(C)C1
O=S1(=O)CON=CN1
164.186
35.7335
-0.383
4
1
18
67.76
N=C1C=CNC(=O)S1(=O)=O
N=C1C=CNC(=O)S1(=O)=O
true
CC1CCCC(C)C1(C)C
N=C1C=CNC(=O)S1(=O)=O
160.154
34.3182
-0.38463
4
2
14
87.09
ON=C1NCC2=NSC=C12
ON=C1NCc2nscc21
false
CCC1CCC2CCCC12
N=C1NCc2nscc21
155.182
37.2772
0.3821
4
2
15
57.51
CCC1=CC2=C(S1)N=CS2
CCc1cc2scnc2s1
false
CCC1CC2CCCC2C1
c1nc2sccc2s1
169.274
46.875
2.9202
3
0
17
12.89
CNC1CS(=O)(=O)CC1=O
CNC1CS(=O)(=O)CC1=O
true
CCC1CC(C)(C)CC1C
O=C1CCS(=O)(=O)C1
163.198
36.5085
-1.4281
4
1
19
63.24
C=CCNS(=O)(=O)NC=O
C=CCNS(=O)(=O)NC=O
true
CCCCC(C)(C)CCC
164.186
36.3192
-1.2472
3
2
18
75.27
S=C(NCCC#C)N1CC1
C#CCCNC(=S)N1CC1
false
CCCCCC(C)C1CC1
C1CN1
154.238
45.6237
0.1998
1
1
20
15.04
NC1=CSC(CCO)=C1Cl
Nc1csc(CCO)c1Cl
false
CCCC1CCC(C)C1C
c1ccsc1
177.656
44.5312
1.5185
3
2
18
46.25
CC1CCC2=NC(=O)SN12
CC1CCc2nc(=O)sn21
false
CC1CC2CCC(C)C2C1
O=c1nc2n(s1)CCC2
156.21
39.406
0.812
4
0
18
34.89
CC(=O)C=CC1=NSN=C1
CC(=O)C=Cc1cnsn1
false
CC(C)CCC1CCCC1
c1cnsn1
154.194
39.624
1.1403
4
0
16
42.85
CNS(=O)(=O)C=CC(C)=C
C=C(C)C=CS(=O)(=O)NC
false
CCC(C)(C)CCC(C)C
161.226
41.9335
0.6254
2
1
21
46.17
CC1=CC(C=C)=C(S1)C#N
C=Cc1cc(C)sc1C#N
false
CCC1CC(C)CC1CC
c1ccsc1
149.218
43.862
2.5712
2
0
17
23.79
CNN=C1SC(C)=CN1O
CNN=c1sc(C)cn1O
false
CCCC1CC(C)CC1C
N=c1[nH]ccs1
159.214
38.8532
0.13042
5
2
19
49.55
NCCN1CCONC1=S
NCCN1CCONC1=S
true
CCCC1CCCCC1C
S=C1NCCON1
161.23
42.3131
-0.9332
3
2
21
50.52
CC1CC(=C)C=CS1(=O)=O
C=C1C=CS(=O)(=O)C(C)C1
false
CC1CCC(C)(C)C(C)C1
C=C1C=CS(=O)(=O)CC1
158.222
41.2788
1.2633
2
0
20
34.14
ClC1=CC=C(Cl)C(=C1)C#C
C#Cc1cc(Cl)ccc1Cl
false
CCC1CC(C)CCC1C
c1ccccc1
171.026
44.397
2.9747
0
0
14
0
CNCC1=CC(Cl)=CN1N
CNCc1cc(Cl)cn1N
false
CCCC1CC(C)CC1C
c1cc[nH]c1
159.62
42.3561
0.5747
3
2
20
42.98
C=CC1=CN(N=C)C(=N)S1
C=Cc1cn(N=C)c(=N)s1
false
CCC1CC(C)C(CC)C1
N=c1[nH]ccs1
153.21
43.2017
1.13577
4
1
17
41.14
NC(=S)NCC1=NC=CO1
NC(=S)NCc1ncco1
false
CC(C)CCC1CCCC1
c1cocn1
157.198
40.1281
0.0078
3
2
17
64.08
CC1=C(C)C(Cl)=C(CN)O1
Cc1oc(CN)c(Cl)c1C
false
CCC1CC(C)C(C)C1C
c1ccoc1
159.616
41.0834
2.00854
2
1
20
39.16
C=CCCS(=O)(=O)CC=C
C=CCCS(=O)(=O)CC=C
true
CCCCC(C)(C)CCC
160.238
43.6648
1.1633
2
0
22
34.14
CC1C2C=NOC2S1(=O)=O
CC1C2C=NOC2S1(=O)=O
true
CC1C2CCCC2C1(C)C
O=S1(=O)CC2C=NOC21
161.182
35.2368
-0.2384
4
0
17
55.73
ClC1=CC=CC2=C1OC=C2
Clc1cccc2ccoc12
false
CC1CCCC2CCCC12
c1ccc2occc2c1
152.58
41.224
3.0862
1
0
15
13.14
CS(=O)(=O)C(=C)COC=C
C=COCC(=C)S(C)(=O)=O
false
CCCCC(C)C(C)(C)C
162.21
40.1328
0.7048
3
0
20
43.37
CNC(C)C1=CSN=C1N
CNC(C)c1csnc1N
false
CCC(C)C1CCCC1C
c1cnsc1
157.242
44.0011
1.0057
4
2
21
50.94
O=C1NCS(=O)(=O)C11CC1
O=C1NCS(=O)(=O)C12CC2
false
CC1CCC(C)(C)C12CC2
O=C1NCS(=O)(=O)C12CC2
161.182
33.8945
-0.9789
3
1
17
63.24
CN1C(CO)C=CS1(=O)=O
CN1C(CO)C=CS1(=O)=O
true
CCC1CCC(C)(C)C1C
O=S1(=O)C=CCN1
163.198
36.6966
-0.8638
3
1
19
57.61
NC1CNC(=S)N(O)C=C1
NC1C=CN(O)C(=S)NC1
false
CC1CCC(C)C(C)CC1
S=C1NC=CCCN1
159.214
41.3416
-0.5933
3
3
19
61.52
CCCC1=CSC(CN)=C1
CCCc1csc(CN)c1
false
CCCC1CCC(CC)C1
c1ccsc1
155.266
46.2054
2.1593
2
1
23
26.02
ClC1=C2CCC2=NNC1=O
O=c1[nH]nc2c(c1Cl)CC2
false
CC1CCC2CCC2C1C
O=c1cc2c(n[nH]1)CC2
156.572
37.2757
0.5219
2
1
15
45.75
CC1=CN=C(CCCN)S1
Cc1cnc(CCCN)s1
false
CCCCC1CCC(C)C1
c1cscn1
156.254
44.2264
1.34282
3
1
22
38.91
CCN(C)C1=NN=C(C)S1
CCN(C)c1nnc(C)s1
false
CCC(C)C1CCC(C)C1
c1nncs1
157.242
43.59
1.30262
4
0
21
29.02
C1OC2C1NC1=C2SC=C1
c1cc2c(s1)C1OCC1N2
false
C1CC2CC3CCC3C2C1
c1cc2c(s1)C1OCC1N2
153.206
40.4227
1.6135
3
1
17
21.26
CC1CC1C#CS(C)(=O)=O
CC1CC1C#CS(C)(=O)=O
true
CC1CC1CCC(C)(C)C
C1CC1
158.222
39.8908
0.6479
2
0
20
34.14
CC#CCOC1=NSC=N1
CC#CCOc1ncsn1
false
CCCCCC1CCCC1
c1ncsn1
154.194
38.854
0.9402
4
0
16
35.01
CNC(C)(C)C1=NSN=C1
CNC(C)(C)c1cnsn1
false
CCC(C)(C)C1CCCC1
c1cnsn1
157.242
41.9947
0.9926
4
1
21
37.81
CC1C(=C)NC(=S)NC1=O
C=C1NC(=S)NC(=O)C1C
false
CC1CC(C)C(C)C(C)C1
C=C1CC(=O)NC(=S)N1
156.21
42.1804
0.1405
2
2
18
41.13
CS(=O)(=O)C(O)C=CC=O
CS(=O)(=O)C(O)C=CC=O
true
CCCCC(C)C(C)(C)C
164.182
36.0546
-0.8955
4
1
18
71.44
CC=C(CS(C)(=O)=O)C#N
CC=C(C#N)CS(C)(=O)=O
false
CCC(CC)CC(C)(C)C
159.21
39.0808
0.50088
3
0
19
57.93
CN1C=CC(=N1)S(C)(=O)=O
Cn1ccc(S(C)(=O)=O)n1
false
CC1CCC(C(C)(C)C)C1
c1cn[nH]c1
160.198
36.3178
-0.1764
4
0
18
51.96
N=CN1CC1C1=CSC=C1
N=CN1CC1c1ccsc1
false
CCC1CC1C1CCCC1
c1cc(C2CN2)cs1
152.222
42.5497
1.71187
2
1
18
26.86
O=C1OC2=C(SC=C12)C#C
C#Cc1scc2c1OC2=O
false
CCC1CCC2C(C)CC12
O=C1Oc2cscc21
150.158
37.2125
1.262
3
0
12
26.3
CC1=C(C#C)N(O)C(=N)S1
C#Cc1c(C)sc(=N)n1O
false
CCC1C(C)CC(C)C1C
N=c1[nH]ccs1
154.194
38.0202
0.55609
4
2
16
49.01
O=C1NN=C(CC2CC2)S1
O=c1[nH]nc(CC2CC2)s1
false
CC1CCC(CC2CC2)C1
O=c1[nH]nc(CC2CC2)s1
156.21
39.1627
0.7839
3
1
18
45.75
NC1=C(SC(C=O)=N1)C#C
C#Cc1sc(C=O)nc1N
false
CCC1CC(C)C(CC)C1
c1cscn1
152.178
39.8489
0.5191
4
1
14
55.98
O=S1(=O)C=CCC11CCO1
O=S1(=O)C=CCC12CCO2
false
CC1(C)CCCC12CCC2
O=S1(=O)C=CCC12CCO2
160.194
35.9768
0.4352
3
0
18
43.37
NCC1=CC=C2SC=CN12
NCc1ccc2sccn12
false
CCC1CCC2CCCC12
c1cc2sccn2c1
152.222
43.1654
1.4595
3
1
18
30.43
CCNC1=C(OC)N=NS1
CCNc1snnc1OC
false
CCCC1CCCC1CC
c1csnn1
159.214
40.6247
0.9785
5
1
19
47.04
S=C1NCC(N1)C1COC1
S=C1NCC(C2COC2)N1
false
CC1CCC(C2CCC2)C1
S=C1NCC(C2COC2)N1
158.226
41.8334
-0.5209
2
2
20
33.29
NC1CC1C(=O)NC(N)=S
NC(=S)NC(=O)C1CC1N
false
CC(C)CC(C)C1CC1C
C1CC1
159.214
41.0105
-1.3066
3
3
19
81.14
OC1CS(=O)(=O)C(=C)C1O
C=C1C(O)C(O)CS1(=O)=O
false
CC1CC(C)(C)C(C)C1C
C=C1CCCS1(=O)=O
164.182
34.9404
-1.3497
4
2
18
74.6
CC1CNC(C1)S(N)(=O)=O
CC1CNC(S(N)(=O)=O)C1
false
CC1CCC(C(C)(C)C)C1
C1CCNC1
164.23
38.6789
-0.7696
3
2
22
72.19
CC(=O)C1=CCNS1(=O)=O
CC(=O)C1=CCNS1(=O)=O
true
CC(C)C1CCCC1(C)C
O=S1(=O)C=CCN1
161.182
35.6865
-0.6077
3
1
17
63.24
CCC(C)(O)S(=O)(=O)C=O
CCC(C)(O)S(=O)(=O)C=O
true
CCC(C)(C)C(C)(C)CC
166.198
36.5851
-0.2901
4
1
20
71.44
CC1=C(CC=O)C(N)=NS1
Cc1snc(N)c1CC=O
false
CCCC1C(C)CCC1C
c1cnsc1
156.21
41.0314
0.77512
4
1
18
55.98
NC(=S)N1OCC=C1C#C
C#CC1=CCON1C(N)=S
false
CCC1CCCC1C(C)C
C1=CNOC1
154.194
41.4924
-0.0057
2
1
16
38.49
CS(=O)(=O)NCCN=CN
CS(=O)(=O)NCCN=CN
true
CCCCCCC(C)(C)C
165.218
40.3929
-1.4774
3
2
21
84.55
CCCNC(=S)N(N)C=C
C=CN(N)C(=S)NCCC
false
CCCCC(C)C(C)CC
159.258
47.1151
0.5901
2
2
23
41.29
CC1(CC2=NSN=C12)C#C
C#CC1(C)Cc2nsnc21
false
CCC1(C)CC2CCCC21
C1Cc2nsnc21
150.206
39.798
0.9851
3
0
16
25.78
O=S1(=O)NC2C3CC2C1O3
O=S1(=O)NC2C3CC2C1O3
true
CC1(C)CC2C3CC2C1C3
O=S1(=O)NC2C3CC2C1O3
161.182
32.6115
-0.9672
3
1
17
55.4
CC(=O)C1CS(=O)(=O)CO1
CC(=O)C1CS(=O)(=O)CO1
true
CC(C)C1CCC(C)(C)C1
O=S1(=O)CCOC1
164.182
34.2078
-0.6535
4
0
18
60.44
NC1=C(CC=O)SC(O)=C1
Nc1cc(O)sc1CC=O
false
CCCC1CC(C)CC1C
c1ccsc1
157.194
40.1642
0.7773
4
2
17
63.32
NC1=CSC(O)=C1C1CN1
Nc1csc(O)c1C1CN1
false
CC1CCC(C)C1C1CC1
c1cc(C2CN2)cs1
156.21
41.1399
0.6802
4
3
18
68.19