smiles
stringlengths
13
37
canonsmiles
stringlengths
12
39
isSmilesEqual
bool
2 classes
generic_scaffold
stringlengths
12
31
scaffold
stringlengths
0
37
rdkit_WT
float64
146
259
rdkit_MR
float64
29.7
65.2
rdkit_LogP
float64
-3.99
5.42
rdkit_HA
float64
0
7
rdkit_HD
float64
0
5
rdkit_NumAtoms
float64
10
35
rdkit_TPSA
float64
0
158
CC(C#N)S(=O)(=O)N1CC1
CC(C#N)S(=O)(=O)N1CC1
true
CCC(C)C(C)(C)C1CC1
C1CN1
160.198
35.5678
-0.45612
3
0
18
60.94
O=S1(=O)CC(C1)OCC#N
N#CCOC1CS(=O)(=O)C1
false
CCCCC1CC(C)(C)C1
O=S1(=O)CCC1
161.182
34.0068
-0.67642
4
0
17
67.16
CC1=C(Cl)C2=NCCN2O1
CC1=C(Cl)C2=NCCN2O1
true
CC1CC2CCCC2C1C
C1=CC2=NCCN2O1
158.588
38.646
1.116
3
0
17
24.83
CN1CC=CS(=O)(=O)C=C1
CN1C=CS(=O)(=O)C=CC1
false
CC1CCCC(C)(C)CC1
O=S1(=O)C=CCNC=C1
159.21
39.8298
0.3315
3
0
19
37.38
CC(=CC#N)S(=O)(=O)C#C
C#CS(=O)(=O)C(C)=CC#N
false
CCCC(C)C(C)(C)CC
155.178
37.1228
0.41928
3
0
15
57.93
CCN(CC)C(=S)N(C)O
CCN(CC)C(=S)N(C)O
true
CCC(CC)C(C)C(C)C
162.258
45.0685
0.9341
2
1
24
26.71
CC(C)(CO)CS(C)(=O)=O
CC(C)(CO)CS(C)(=O)=O
true
CCC(C)(C)CC(C)(C)C
166.242
40.5776
0.0495
3
1
24
54.37
CC1=C(CCC=O)N=NS1
Cc1snnc1CCC=O
false
CCCCC1CCCC1C
c1csnn1
156.21
39.031
0.97802
4
0
18
42.85
COC1=CN(N)C(C)=C1Cl
COc1cn(N)c(C)c1Cl
false
CCC1CC(C)C(C)C1C
c1cc[nH]c1
160.604
40.8814
1.17232
3
1
19
40.18
CC1=C(SN=C1C=O)C=C
C=Cc1snc(C=O)c1C
false
CCC1CCC(CC)C1C
c1cnsc1
153.206
42.3295
1.90702
3
0
17
29.96
NC(C#C)C1=C(O)SC=N1
C#CC(N)c1ncsc1O
false
CCC(C)C1CCCC1C
c1cscn1
154.194
39.5402
0.4817
4
2
16
59.14
O=C1CNCC2=C1N=NS2
O=C1CNCc2snnc21
false
CC1CCCC2CCCC12
O=C1CNCc2snnc21
155.182
35.9462
-0.176
5
1
15
54.88
CNN1N=C(C)C(Cl)=C1C
CNn1nc(C)c(Cl)c1C
false
CCC1CC(C)C(C)C1C
c1cn[nH]c1
159.62
41.9957
1.32664
3
1
20
29.85
OC1=CN=C(C=O)C=C1Cl
O=Cc1cc(Cl)c(O)cn1
false
CCC1CCC(C)C(C)C1
c1ccncc1
157.556
36.2993
1.2531
3
1
14
50.19
O=CC=CCS(=O)(=O)C#N
N#CS(=O)(=O)CC=CC=O
false
CCCCCC(C)(C)CC
159.166
34.6038
-0.36262
4
0
15
75
N=CN1CC2CC1S2(=O)=O
N=CN1CC2CC1S2(=O)=O
true
CCC1CC2CC1C2(C)C
O=S1(=O)C2CNC1C2
160.198
36.6025
-0.57773
3
1
18
61.23
CC1CN1CC1=CN=CS1
CC1CN1Cc1cncs1
false
CC1CC1CC1CCCC1
c1ncc(CN2CC2)s1
154.238
41.986
1.3472
3
0
20
15.9
CCCC1CN(C)S1(=O)=O
CCCC1CN(C)S1(=O)=O
true
CCCC1CC(C)C1(C)C
O=S1(=O)CCN1
163.242
40.2458
0.4303
2
0
23
37.38
OC1CN2C1=C(Cl)C=C2O
Oc1cc(Cl)c2n1CC2O
false
CC1CC(C)C2C(C)CC12
c1cc2n(c1)CC2
159.572
36.0666
0.8941
3
2
16
45.39
ClC1=C(C#C)N(C=N)N=C1
C#Cc1c(Cl)cnn1C=N
false
CCC1CCC(C)C1CC
c1cn[nH]c1
153.572
39.3537
0.97297
3
1
14
41.67
O=CS(=O)(=O)CNC1CC1
O=CS(=O)(=O)CNC1CC1
true
CCC(C)(C)CCC1CC1
C1CC1
163.198
36.695
-0.6991
4
1
19
63.24
CC=C(CO)C1=NN=NS1
CC=C(CO)c1nnns1
false
CCC(CC)C1CCCC1
c1nnns1
157.198
38.4408
0.3287
5
1
17
58.9
OC1=C2COC(C=C2)=C1Cl
Oc1c2ccc(c1Cl)OC2
false
CC1C2CCC(CC2)C1C
c1cc2ccc1CO2
156.568
37.4488
1.938
2
1
15
29.46
CCONC(=S)N(N)CC
CCONC(=S)N(N)CC
true
CCCCC(C)C(C)CC
163.246
43.9271
0.008
3
2
23
50.52
CC1=C(COS1(=O)=O)C#C
C#CC1=C(C)S(=O)(=O)OC1
false
CCC1CCC(C)(C)C1C
O=S1(=O)C=CCO1
158.178
36.4048
0.2536
3
0
16
43.37
CC1=CSC=C1OC(N)=N
Cc1cscc1OC(=N)N
false
CC(C)CC1CCCC1C
c1ccsc1
156.21
41.5981
1.32879
3
2
18
59.1
CCCS(=O)(=O)OCC#N
CCCS(=O)(=O)OCC#N
true
CCCCC(C)(C)CCC
163.198
35.6428
0.26638
4
0
19
67.16
CC1=C(SC(N)=C1O)C=C
C=Cc1sc(N)c(O)c1C
false
CCC1CC(C)C(C)C1C
c1ccsc1
155.222
45.2242
1.98732
3
2
19
46.25
CCC(N)C1COS1(=O)=O
CCC(N)C1COS1(=O)=O
true
CCC(C)C1CCC1(C)C
O=S1(=O)CCO1
165.214
36.9262
-0.5477
4
1
21
69.39
CNC1=C(CN)C=C(C)S1
CNc1sc(C)cc1CN
false
CCC1CC(C)CC1CC
c1ccsc1
156.254
46.4941
1.55692
3
2
22
38.05
NS(=O)(=O)C1(CCC1)C=C
C=CC1(S(N)(=O)=O)CCC1
false
CCC1(C(C)(C)C)CCC1
C1CCC1
161.226
39.8862
0.3836
2
1
21
60.16
OC=C1COC2=C1C=NS2
OC=C1COc2sncc21
false
CCC1CCC2CCCC12
C=C1COc2sncc21
155.178
38.2148
1.4344
4
1
15
42.35
CC(C)C1=CC(NO)=NS1
CC(C)c1cc(NO)ns1
false
CCC1CCC(C(C)C)C1
c1cnsc1
158.226
41.6122
2.0676
4
2
20
45.15
CCNS(=O)(=O)N(O)C=C
C=CN(O)S(=O)(=O)NCC
false
CCCC(C)(C)C(C)CC
166.202
36.419
-0.3246
3
2
20
69.64
O=S1(=O)CNC2=NC=CN12
O=S1(=O)CNc2nccn21
false
CC1(C)CCC2CCCC21
O=S1(=O)CNc2nccn21
159.17
35.0345
-0.556
5
1
15
63.99
CCC1CC2=C(O1)SC=N2
CCC1Cc2ncsc2O1
false
CCC1CC2CCCC2C1
c1nc2c(s1)OCC2
155.222
40.525
1.8566
3
0
19
22.12
CCS(=O)(=O)N(N)C1CC1
CCS(=O)(=O)N(N)C1CC1
true
CCC(C)(C)C(C)C1CC1
C1CC1
164.23
38.5092
-0.3258
3
1
22
63.4
CN1C(=O)C=C(N)S1(=O)=O
CN1C(=O)C=C(N)S1(=O)=O
true
CC1CC(C)C(C)(C)C1C
O=C1C=CS(=O)(=O)N1
162.17
33.9602
-1.4117
4
1
16
80.47
CC1=C(Cl)C(OC=O)=CN1
Cc1[nH]cc(OC=O)c1Cl
false
CCCC1CCC(C)C1C
c1cc[nH]c1
159.572
37.2317
1.51172
2
1
16
42.09
NC1=CS(=O)(=O)C=C1CO
NC1=CS(=O)(=O)C=C1CO
true
CCC1CC(C)(C)CC1C
O=S1(=O)C=CC=C1
161.182
36.359
-0.9089
4
2
17
80.39
OC1C=CC2NC(=S)NC12
OC1C=CC2NC(=S)NC12
true
CC1CC2CCC(C)C2C1
S=C1NC2C=CCC2N1
156.21
41.5922
-0.868
2
3
18
44.29
CC1=C2CC(=C)CC2=CS1
C=C1Cc2csc(C)c2C1
false
CC1CC2CCC(C)C2C1
C=C1Cc2cscc2C1
150.246
45.604
2.71132
1
0
20
0
ClC1=C(OC=NC1=N)C=C
C=Cc1ocnc(=N)c1Cl
false
CCC1CCCC(C)C1C
N=c1ccocn1
156.572
37.4587
1.45047
3
1
15
49.88
NC1=COC(S1)=NN1CC1
Nc1coc(=NN2CC2)s1
false
CC1CCC(CC2CC2)C1
c1csc(=NN2CC2)o1
157.198
38.1334
0.0546
5
1
17
54.53
CCC(O)C1CNS1(=O)=O
CCC(O)C1CNS1(=O)=O
true
CCC(C)C1CCC1(C)C
O=S1(=O)CCN1
165.214
37.0083
-0.9411
3
2
21
66.4
CC12CS(=O)(=O)C1NN=C2
CC12C=NNC1S(=O)(=O)C2
false
CC1(C)CC2(C)CCCC12
O=S1(=O)CC2C=NNC21
160.198
37.3095
-0.6638
4
1
18
58.53
CCS(=O)(=O)NN=CCO
CCS(=O)(=O)NN=CCO
true
CCCCCC(C)(C)CC
166.202
38.1743
-1.0962
4
2
20
78.76
CC1=NC2=C(S1)C=NOC2
Cc1nc2c(s1)C=NOC2
false
CC1CC2CCCCC2C1
C1=NOCc2ncsc21
154.194
39.234
1.31562
4
0
16
34.48
CC12CCC(C)(O1)S2(=O)=O
CC12CCC(C)(O1)S2(=O)=O
true
CC12CCC(C)(C1)C2(C)C
O=S1(=O)C2CCC1O2
162.21
36.0488
0.6576
3
0
20
43.37
NC(=S)N1C2CCNCC12
NC(=S)N1C2CCNCC21
false
CC(C)C1C2CCCCC21
C1CC2NC2CN1
157.242
43.6871
-0.7239
2
2
21
41.06
CC1C(C)C1C1=CN=CS1
CC1C(C)C1c1cncs1
false
CC1C(C)C1C1CCCC1
c1ncc(C2CC2)s1
153.25
43.183
2.5125
2
0
21
12.89
CC(C=C)C1=C(Cl)C=CS1
C=CC(C)c1sccc1Cl
false
CCC(C)C1CCCC1C
c1ccsc1
172.68
47.941
3.691
1
0
19
0
CC1C(CCO)OS1(=O)=O
CC1C(CCO)OS1(=O)=O
true
CCCC1CC(C)(C)C1C
O=S1(=O)CCO1
166.198
34.9576
-0.5141
4
1
20
63.6
ON(C1CC1)S(=O)(=O)C#C
C#CS(=O)(=O)N(O)C1CC1
false
CCC(C)(C)C(C)C1CC1
C1CC1
161.182
34.4003
-0.2395
3
1
17
57.61
CC(=N)NC(=S)NCC=C
C=CCNC(=S)NC(C)=N
false
CCCCC(C)CC(C)C
157.242
47.3341
0.63367
2
3
21
47.91
CC1=CC(O)=C(CC=O)S1
Cc1cc(O)c(CC=O)s1
false
CCCC1CC(C)CC1C
c1ccsc1
156.206
40.4888
1.50352
3
1
18
37.3
CC1CS(=O)(=O)C(O1)C#N
CC1CS(=O)(=O)C(C#N)O1
false
CCC1CC(C)CC1(C)C
O=S1(=O)CCOC1
161.182
33.7348
-0.33042
4
0
17
67.16
COC1=CN(O)C(C)=C1Cl
COc1cn(O)c(C)c1Cl
false
CCC1CC(C)C(C)C1C
c1cc[nH]c1
161.588
37.9155
1.69582
3
1
18
34.39
O=S1(=O)CC2=C(CCC2)C1
O=S1(=O)CC2=C(CCC2)C1
true
CC1(C)CC2CCCC2C1
O=S1(=O)CC2=C(CCC2)C1
158.222
39.5308
0.8953
2
0
20
34.14
CCNC(=S)NC(C)C=C
C=CC(C)NC(=S)NCC
false
CCCC(C)CC(C)CC
158.27
49.0694
1.0449
1
2
24
24.06
O=CNCCC1=NSN=C1
O=CNCCc1cnsn1
false
CCCCCC1CCCC1
c1cnsn1
157.198
37.6797
-0.1734
4
1
17
54.88
CC1CC2=C(O)SN=C2N1
CC1Cc2c(nsc2O)N1
false
CC1CC2CCC(C)C2C1
c1snc2c1CCN2
156.21
40.5675
1.2052
4
2
18
45.15
COC1=NC=NC(C)=C1Cl
COc1ncnc(C)c1Cl
false
CCC1CCCC(C)C1C
c1cncnc1
158.588
38.331
1.44702
3
0
17
35.01
CN(C)C(=S)NC(=C)C=O
C=C(C=O)NC(=S)N(C)C
false
CCC(C)CC(C)C(C)C
158.226
44.6247
0.1351
2
1
20
32.34
CC1N(CS1(=O)=O)N=CN
CC1N(N=CN)CS1(=O)=O
false
CCCC1CC(C)(C)C1C
O=S1(=O)CNC1
163.202
37.7672
-1.0777
4
1
19
75.76
CC1=CSC2=C1C1CN2C1
Cc1csc2c1C1CN2C1
false
CC1CCC2C3CC(C3)C12
c1cc2c(s1)N1CC2C1
151.234
44.01
1.97372
2
0
19
3.24
NC1=C(NSC1=N)C1CO1
N=c1s[nH]c(C2CO2)c1N
false
CC1CCC(C2CC2)C1C
N=c1cc(C2CO2)[nH]s1
157.198
37.6298
0.20917
4
3
17
78.19
CC=C1CC2=CSN=C2C1
CC=C1Cc2csnc2C1
false
CCC1CC2CCCC2C1
C=C1Cc2csnc2C1
151.234
43.279
2.188
2
0
19
12.89
CC1=CSC2=C1NC=C2Cl
Cc1csc2c(Cl)c[nH]c12
false
CC1CCC2C(C)CCC12
c1cc2sccc2[nH]1
171.652
45.9227
3.19122
1
1
16
15.79
ClC1=CNC=C(C#N)C1=N
N#Cc1c[nH]cc(Cl)c1=N
false
CCC1CCCC(C)C1C
N=c1cc[nH]cc1
153.572
36.3724
1.01925
2
2
14
63.43
OC1C2NC=CS(=O)(=O)C12
O=S1(=O)C=CNC2C(O)C21
false
CC1C2CCCC(C)(C)C12
O=S1(=O)C=CNC2CC21
161.182
34.7783
-1.4127
4
2
17
66.4
NC1=NSC2=C1C=NOC2
Nc1nsc2c1C=NOC2
false
CC1CCC2CCCCC12
C1=NOCc2sncc21
155.182
38.9094
0.5894
5
1
15
60.5
ClC1=C(C#N)C(=N)OC=C1
N#Cc1c(Cl)ccoc1=N
false
CCC1C(C)CCCC1C
N=c1cccco1
154.556
34.2877
1.28415
3
1
13
60.78
CCNC(=N)OS(C)(=O)=O
CCNC(=N)OS(C)(=O)=O
true
CCCC(C)CC(C)(C)C
166.202
37.3322
-0.49313
4
2
20
79.25
CS(=O)(=O)CC1(CC1)C#C
C#CC1(CS(C)(=O)=O)CC1
false
CCC1(CC(C)(C)C)CC1
C1CC1
158.222
40.2108
0.4444
2
0
20
34.14
CC1=NC(=O)C(Cl)=CC=C1
Cc1cccc(Cl)c(=O)n1
false
CC1CCCC(C)C(C)C1
O=c1cccccn1
155.584
40.254
1.40362
2
0
16
29.96
CCC(=NN)C1=CSC=N1
CCC(=NN)c1cscn1
false
CCC(CC)C1CCCC1
c1cscn1
155.226
43.1294
1.2159
4
1
19
51.27
CC(C)=CS(=O)(=O)NC=N
CC(C)=CS(=O)(=O)NC=N
true
CCCC(C)(C)CC(C)C
162.214
40.2702
0.43657
3
2
20
70.02
CN1SC=CC1=NCC#N
Cn1sccc1=NCC#N
false
CCCCC1CCCC1C
N=c1ccs[nH]1
153.21
39.333
0.51088
4
0
17
41.08
CC1CCC=CCS1(=O)=O
CC1CCC=CCS1(=O)=O
true
CC1CCCCCC1(C)C
O=S1(=O)CC=CCCC1
160.238
41.6228
1.1397
2
0
22
34.14
S=C1NC=CCOC=CN1
S=C1NC=CCOC=CN1
true
CC1CCCCCCCC1
S=C1NC=CCOC=CN1
156.21
43.1014
0.4656
2
2
18
33.29
C=C1NS(=O)(=O)C(=C)C1=O
C=C1NS(=O)(=O)C(=C)C1=O
true
CC1CC(C)(C)C(C)C1C
C=C1NS(=O)(=O)C(=C)C1=O
159.166
35.3425
-0.4841
3
1
15
63.24
C=CNS(=O)(=O)COC=C
C=CNS(=O)(=O)COC=C
true
CCCCC(C)(C)CCC
163.198
38.4015
0.1669
3
1
19
55.4
CC1=C(NCC#N)N=NS1
Cc1snnc1NCC#N
false
CCCCC1CCCC1C
c1csnn1
154.198
38.7487
0.782
5
1
16
61.6
C=C1C=CS(=O)(=O)C1C#C
C#CC1C(=C)C=CS1(=O)=O
false
CCC1C(C)CCC1(C)C
C=C1C=CS(=O)(=O)C1
154.19
39.8208
0.4865
2
0
16
34.14
O=S1(=O)C2CC3COC2C13
O=S1(=O)C2CC3COC2C31
false
CC1(C)C2CC3CCC2C31
O=S1(=O)C2CC3COC2C31
160.194
34.3428
-0.4293
3
0
18
43.37
COC1=C(NC=N)N=CS1
COc1scnc1NC=N
false
CCCC1CCCC1CC
c1cscn1
157.198
41.0724
1.17067
4
2
17
58
C=CC1CNC2=C1C=CS2
C=CC1CNc2sccc21
false
CCC1CCC2CCCC12
c1cc2c(s1)NCC2
151.234
45.7467
2.4432
2
1
19
12.03
CCC1=C(Cl)C=C(O)N1N
CCc1c(Cl)cc(O)n1N
false
CCC1C(C)CC(C)C1C
c1cc[nH]c1
160.604
40.6352
1.1233
3
2
19
51.18
CCOC1=C2OCC2=CS1
CCOc1scc2c1OC2
false
CCCC1CCC2CCC12
c1scc2c1CO2
156.206
39.82
2.0392
3
0
18
18.46
O=S1(=O)C2CC1C(=C2)C#C
C#CC1=CC2CC1S2(=O)=O
false
CCC1CC2CC1C2(C)C
O=S1(=O)C2C=CC1C2
154.19
38.0288
0.1153
2
0
16
34.14
CC(C)NS(=O)(=O)N(C)N
CC(C)NS(=O)(=O)N(C)N
true
CC(C)CC(C)(C)C(C)C
167.234
39.1419
-0.9653
3
2
23
75.43
CC(=C)C(=O)C1=NSC=N1
C=C(C)C(=O)c1ncsn1
false
CC(C)C(C)C1CCCC1
c1ncsn1
154.194
39.0535
1.2969
4
0
16
42.85
[O-][N+](=O)C1=NC=CC=C1Cl
O=[N+]([O-])c1ncccc1Cl
false
CC(C)C1CCCCC1C
c1ccncc1
158.544
35.9014
1.6432
3
0
13
56.03
CC1CNCS(=O)(=O)NC1
CC1CNCS(=O)(=O)NC1
true
CC1CCCC(C)(C)CC1
O=S1(=O)CNCCCN1
164.23
38.9562
-0.8974
3
2
22
58.2
CC#CC1=C(N)C(O)=CS1
CC#Cc1scc(O)c1N
false
CCCC1CCC(C)C1C
c1ccsc1
153.206
42.9482
1.4073
3
2
17
46.25
CN1C(C)=CC2CN2C1=S
CC1=CC2CN2C(=S)N1C
false
CC1CC2CC2C(C)C1C
S=C1NC=CC2CN12
154.238
44.612
0.8047
1
0
20
6.25
CCCC1=NS(=O)(=O)N=C1
CCCC1=NS(=O)(=O)N=C1
true
CCCC1CCC(C)(C)C1
O=S1(=O)N=CC=N1
160.198
39.7548
0.5567
2
0
18
58.86
CC1=NC2=C(O1)C(C)=NS2
Cc1nc2snc(C)c2o1
false
CC1CC2CCC(C)C2C1
c1nc2sncc2o1
154.194
39.155
1.90114
4
0
16
38.92
CON(CC#C)S(N)(=O)=O
C#CCN(OC)S(N)(=O)=O
false
CCCC(CC)C(C)(C)C
164.186
35.6552
-1.3135
3
1
18
72.63