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42413883
10.1016/j.ejpb.2026.115178
High-concentration biologic formulations: challenges, strategies, and emerging technologies for subcutaneous delivery
The growing demand for subcutaneous (SC) self-administration of biotherapeutics, driven by the rising prevalence of chronic diseases and healthcare cost-containment pressures, has accelerated the development of high-concentration formulations (HCFs). However, protein concentrations exceeding 100 mg/mL introduce signifi...
Eur J Pharm Biopharm
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2026 Sep
2,026
[ "Ma J" ]
Ma J
Ma J
[ "Humans", "Excipients", "Injections, Subcutaneous", "Biological Products", "Chemistry, Pharmaceutical", "Drug Delivery Systems", "Animals", "Solubility", "Drug Compounding", "Freeze Drying", "Viscosity", "Hyaluronoglucosaminidase", "Crystallization", "Technology, Pharmaceutical", "Protei...
[ "Journal Article", "Review" ]
226
null
115178
null
0939-6411
eng
https://pubmed.ncbi.nlm.nih.gov/42413883/
UjoTgZKqkiah7PEEk
sMHJETYjjnZkPtPfs
42412954
10.2478/acph-2026-0018
SEM/EDS analysis as a complementary tool for continuous improvement of cefixime granules for oral suspension
The aim of this study was to evaluate scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDS) as complementary analytical tools for supporting continuous improvement in pharmaceutical granule manufacturing. Pilot-scale cefixime granules for oral suspension were prepared as defined pr...
Acta Pharm
Acta pharmaceutica (Zagreb, Croatia)
2026 Jun 1
2,026
[ "Mitrevska I", "Karpicarov D", "Mihailovska A", "Mirakovski D", "Paneva O", "Petrushevski G" ]
Mitrevska I
Petrushevski G
[ "Cefixime", "Microscopy, Electron, Scanning", "Spectrometry, X-Ray Emission", "Anti-Bacterial Agents", "Suspensions", "Administration, Oral", "Chemistry, Pharmaceutical", "Drug Compounding", "Surface Properties", "Bulk Drugs" ]
[ "Journal Article" ]
76
2
1-11
null
1330-0075
eng
https://pubmed.ncbi.nlm.nih.gov/42412954/
UjoTgZKqkiah7PEEk
sMHJETYjjnZkPtPfs
42410104
10.1208/s12249-026-03494-4
Hot-Melt Extrusion of Bupropion with Three Ethylcellulose Grades for Pellet Feedstock Preparation and Screw-Based 3D Printing of Sustained-Release Tablets
3D printing has emerged as a novel technology for producing personalized dosage forms tailored to patients' therapeutic needs. Hot-melt extrusion (HME) is commonly used to produce filaments for most extrusion-based 3D printers. This study aimed to investigate the effect of three different ethylcellulose (EC) grades (7N...
AAPS PharmSciTech
AAPS PharmSciTech
2026 Jul 6
2,026
[ "Protopapa C", "Junqueira LA", "Kolipaka SS", "Economidou S", "Pappas D", "Douroumis D", "Vlachou M" ]
Protopapa C
Vlachou M
[ "Printing, Three-Dimensional", "Delayed-Action Preparations", "Cellulose", "Tablets", "Bupropion", "Drug Liberation", "Porosity", "Drug Compounding", "Solubility", "Chemistry, Pharmaceutical", "Hot Melt Extrusion Technology", "Calorimetry, Differential Scanning", "Viscosity", "Excipients",...
[ "Journal Article" ]
27
5
null
null
1530-9932
eng
https://pubmed.ncbi.nlm.nih.gov/42410104/
UjoTgZKqkiah7PEEk
sMHJETYjjnZkPtPfs
42545427
10.1007/s00122-026-05329-z
Prioritization of deleterious mutations informs genomic prediction and increases the rate of gain in common bean (Phaseolus vulgaris L.), a simulation study
Predicted deleterious mutations (SNPs) have different distributions of effects compared to random SNPs based on population composition. Variant prioritization of markers based on deleterious scores can improve the prediction of yield. Favoring mating schemes between parents with fewer highly deleterious mutations can i...
Theor Appl Genet
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
2026 Aug 3
2,026
[ "Cordoba-Novoa H", "Hoyos-Villegas V" ]
Cordoba-Novoa H
Hoyos-Villegas V
[ "Phaseolus", "Mutation", "Models, Genetic", "Genome, Plant", "Plant Breeding", "Computer Simulation", "Polymorphism, Single Nucleotide", "Genomics", "Phenotype", "Genotype", "Random Forest", "Genetic Markers" ]
[ "Journal Article" ]
139
8
null
null
0040-5752
eng
https://pubmed.ncbi.nlm.nih.gov/42545427/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42545405
10.1007/s10482-026-02392-w
Genomic and polyphasic characterization of six novel Hymenobacter species isolated from soil in Korea
Six bacterial strains (BT523T, BT559T, 15J16-1T3BT, BT730T, DG25AT, and DG25BT) were isolated from soil samples in Korea and assigned to the family Hymenobacteraceae (order Cytophagales, class Cytophagia). Phylogenetic analysis based on 16S rRNA gene sequences showed that the strains formed distinct lineages within the...
Antonie Van Leeuwenhoek
Antonie van Leeuwenhoek
2026 Aug 3
2,026
[ "Park Y", "Park S", "Maeng S", "Kim MK" ]
Park Y
Kim MK
[ "Soil Microbiology", "Phylogeny", "Republic of Korea", "RNA, Ribosomal, 16S", "Cytophagaceae", "DNA, Bacterial", "Genome, Bacterial", "Sequence Analysis, DNA", "Bacterial Typing Techniques", "Base Composition", "Genomics", "Fatty Acids" ]
[ "Journal Article" ]
119
9
null
null
0003-6072
eng
https://pubmed.ncbi.nlm.nih.gov/42545405/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42545397
10.1007/s10695-026-01762-5
Toxicoproteomic analysis reveals arsenic-induced alterations in eye lens proteins of Labeo rohita
Arsenic occurs extensively in the environment and is classified as a potent carcinogenic substance in humans. Prolonged intake of water contaminated with arsenic results in the development of arsenicosis. In the present study, a toxicoproteomic approach was employed to elucidate arsenic-induced alterations in lens prot...
Fish Physiol Biochem
Fish physiology and biochemistry
2026 Aug 3
2,026
[ "Bhattacharjee S", "Pati MK", "Bisai K", "Mohanty BP" ]
Bhattacharjee S
Mohanty BP
[ "Animals", "Lens, Crystalline", "Water Pollutants, Chemical", "Proteomics", "Crystallins", "Cyprinidae", "Arsenic", "Fish Proteins", "Arsenites", "Sodium Compounds", "Electrophoresis, Gel, Two-Dimensional", "Cataract", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization" ]
[ "Journal Article" ]
52
4
null
null
0920-1742
eng
https://pubmed.ncbi.nlm.nih.gov/42545397/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42544692
10.1111/mec.70497
Ancient Transposable Elements Sustain Global Ecological Adaptation Despite Chronically Low Nucleotide Diversity
Transposable elements (TEs) are dynamic components of eukaryotic genomes and a major source of structural and regulatory variation, yet their contribution to ecological adaptation over evolutionary time remains unresolved. This uncertainty is particularly acute in species that occupy broad environmental niches despite ...
Mol Ecol
Molecular ecology
2026 Aug
2,026
[ "Zhang A", "Bemmels JB", "Wei N" ]
Zhang A
Wei N
[ "DNA Transposable Elements", "Adaptation, Physiological", "Araceae", "Selection, Genetic", "Evolution, Molecular", "Genetics, Population", "Polymorphism, Genetic", "Sequence Analysis, DNA", "Genetic Variation", "DNA, Plant", "Polymorphism, Single Nucleotide", "Genome, Plant", "Adaptation, Bi...
[ "Journal Article" ]
35
15
e70497
null
0962-1083
eng
https://pubmed.ncbi.nlm.nih.gov/42544692/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42544045
10.1158/2159-8290.CD-26-1036
Genomics of Subsequent Neoplasms in Childhood Cancer Survivors
Brady and colleagues investigated the mutational consequences of cancer treatment on the genomes of 160 childhood cancer survivors who developed a subsequent neoplasm (SN). Their research aids in directing the next steps toward the prevention of SNs. See related article by Brady et al., p. 1590.
Cancer Discov
Cancer discovery
2026 Aug 3
2,026
[ "Bertrums EJM", "van Boxtel R" ]
Bertrums EJM
van Boxtel R
[ "Humans", "Neoplasms", "Genomics", "Cancer Survivors", "Child", "Mutation" ]
[ "Journal Article" ]
16
8
1483-1485
null
2159-8274
eng
https://pubmed.ncbi.nlm.nih.gov/42544045/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543827
10.3881/j.issn.1000-503X.16943
Application of a 64-plex Panel in the Study of Genetic Polymorphism and Population Structure of Kyrgyz Group
Objective To assess the forensic application value of 59 InDel loci and two miniSTR loci in Chinese Kyrgyz group,and to explore the genetic structure and genetic background of this group. Methods A total of 99 Kyrgyz individuals were genotyped through the 64-plex panel,which was developed independently by our lab.Allel...
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
2026 Jun
2,026
[ "Wu XL", "Liu QL", "Cai MM", "Lan Q", "Liu YF", "Zhu BF" ]
Wu XL
Zhu BF
[ "Humans", "Polymorphism, Genetic", "Genetics, Population", "Gene Frequency", "Asian People", "Microsatellite Repeats", "Genotype", "INDEL Mutation", "Kyrgyzstan" ]
[ "Journal Article" ]
48
3
422-431
null
1000-503X
eng
https://pubmed.ncbi.nlm.nih.gov/42543827/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543658
10.11406/rinketsu.67.846
[Clinical management of familial platelet disorder with associated myeloid malignancies: at the crossroads of hematology and clinical genetics]
With the widespread adoption of genomic testing, germline predisposition syndromes such as RUNX1-familial platelet disorder with associated myeloid malignancy (FPD-MM) are increasingly encountered in routine hematological practice. FPD-MM is driven by RUNX1 haploinsufficiency, which initially manifests as quantitative ...
Rinsho Ketsueki
[Rinsho ketsueki] The Japanese journal of clinical hematology
2026
2,026
[ "Watanabe M" ]
Watanabe M
Watanabe M
[ "Humans", "Blood Platelet Disorders", "Myeloproliferative Disorders", "Hematologic Neoplasms", "Genetic Predisposition to Disease", "Genetic Counseling", "Germ-Line Mutation", "Core Binding Factor Alpha 2 Subunit", "Genetic Testing", "Hematopoietic Stem Cell Transplantation", "Leukemia, Myeloid,...
[ "Journal Article", "Review", "English Abstract" ]
67
7
846-853
null
0485-1439
jpn
https://pubmed.ncbi.nlm.nih.gov/42543658/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543651
10.11406/rinketsu.67.794
[Hematopoietic cell transplantation in the era of genome analysis]
Genomic information for hematologic malignancies is now routinely available in clinical practice, supporting the adaptation of hematopoietic cell transplantation, selection of conditioning intensity, and implementation of post-transplant maintenance therapy through refinement of disease risk assessment and minimal resi...
Rinsho Ketsueki
[Rinsho ketsueki] The Japanese journal of clinical hematology
2026
2,026
[ "Nannya Y" ]
Nannya Y
Nannya Y
[ "Humans", "Hematopoietic Stem Cell Transplantation", "Myelodysplastic Syndromes", "Genomics", "Neoplasm, Residual", "Polymorphism, Single Nucleotide", "Hematologic Neoplasms", "Leukemia, Myeloid, Acute", "Graft vs Host Disease" ]
[ "Journal Article", "Review", "English Abstract" ]
67
7
794-801
null
0485-1439
jpn
https://pubmed.ncbi.nlm.nih.gov/42543651/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543640
10.11406/rinketsu.67.716
[Genomic abnormalities in myeloproliferative neoplasms]
Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are driven by recurrent driver mutations and evolve through the stepwise accumulation of additional genetic alterations and clonal evolution. Some large cohort studies have demonstrated that individual additional mutations significantly influence prog...
Rinsho Ketsueki
[Rinsho ketsueki] The Japanese journal of clinical hematology
2026
2,026
[ "Ogata H", "Minami Y" ]
Ogata H
Minami Y
[ "Humans", "Myeloproliferative Disorders", "Mutation", "Genomics", "Prognosis" ]
[ "Journal Article", "Review", "English Abstract" ]
67
7
716-724
null
0485-1439
jpn
https://pubmed.ncbi.nlm.nih.gov/42543640/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543607
10.1248/yakushi.26-00016
[Development of Drug Discovery Research Based on the Discovery of AlkB Homolog 3 and Establishment of an Academic Drug Discovery Platform]
The field of epitranscriptomics, an area of genetics concerning the regulation of gene expression via post-transcriptional RNA modification, is currently attracting substantial research attention. In epitranscriptomics, proteins, collectively termed writers, erasers, and readers, enter into complex interactions that co...
Yakugaku Zasshi
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
2026
2,026
[ "Tsujikawa K" ]
Tsujikawa K
Tsujikawa K
[ "Drug Discovery", "Humans", "Animals", "AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase", "Epitranscriptomics", "Neoplasms", "Epitranscriptome", "Drug Development", "Mice" ]
[ "Journal Article", "Review", "English Abstract" ]
146
8
683-696
null
0031-6903
jpn
https://pubmed.ncbi.nlm.nih.gov/42543607/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543364
10.19540/j.cnki.cjcmm.20260414.701
[Investigation on antidepressant mechanism of Piper laetispicum extract based on quantitative proteomics and zebrafish model of depression induced by chronic unpredictable mild stress]
This study aimed to evaluate the antidepressant activity of Piper laetispicum extract and preliminarily explore its underlying mechanism using a zebrafish model of depression combined with quantitative proteomics. A chronic unpredictable mild stress(CUMS) paradigm was employed to establish the depression model. AB stra...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jul
2,026
[ "Duan YA", "Wang YJ", "Bian XF", "Dai GL", "Ju WZ" ]
Duan YA
Ju WZ
[ "Animals", "Zebrafish", "Proteomics", "Antidepressive Agents", "Depression", "Piper", "Disease Models, Animal", "Male", "Tumor Necrosis Factor-alpha", "Interleukin-1beta", "Brain-Derived Neurotrophic Factor", "Humans", "Stress, Psychological", "Drugs, Chinese Herbal", "Brain", "Plant E...
[ "English Abstract", "Journal Article" ]
51
13
3742-3750
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543364/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42543297
10.19540/j.cnki.cjcmm.20260223.401
[Research and application of omics technologies in genetic breeding of medicinal plants]
Medicinal plants represent a critical resource for both traditional medicine and contemporary natural product research. Studies on their genetic breeding are of paramount significance in ensuring the quality of medicinal materials, enhancing the content of bioactive constituents, and cultivating elite varieties. With t...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jun
2,026
[ "Liu Y", "Qi YJ", "Quan WY", "Jia XW", "Zeng CY", "Wang HZ", "Gao SF", "Guo DQ", "Guo WC", "Zhang XJ", "Chen HG", "DU T" ]
Liu Y
DU T
[ "Plants, Medicinal", "Plant Breeding", "Genomics", "Multiomics", "Proteomics", "Metabolomics" ]
[ "Journal Article", "Review", "English Abstract" ]
51
12
3387-3395
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543297/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542532
10.1007/978-1-0716-5166-7_14
Profiling O-Acetylation in Sialoglycans Using MALDI-TOF and LC-MS/MS with Methylamidation and Permethylation Derivatization
O-acetylation of sialoglycans plays a critical role in modulating the structural and functional properties of glycoproteins, with implications in immune response, cell signaling, and disease pathology. Among sialic acids, N-acetylneuraminic acid (Neu5Ac) and its derivatives have garnered attention as biomarkers for var...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Wu Z", "Sirois I" ]
Wu Z
Sirois I
[ "Acetylation", "Tandem Mass Spectrometry", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization", "Methylation", "Liquid Chromatography-Mass Spectrometry", "Polysaccharides", "Humans", "Glycomics", "Chromatography, Liquid", "Sialic Acids" ]
[ "Journal Article" ]
3018
null
211-225
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542532/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542531
10.1007/978-1-0716-5166-7_13
PEPPI-SP3: A Gel-Based High-Resolution Sample Preparation Workflow for In-Depth Top-Down Analysis of Intact Proteoforms by Mass Spectrometry
Top-down proteomics enables large-scale identification of proteoforms by analyzing intact proteins extracted from biological samples using mass spectrometry systems coupled with liquid chromatography or capillary electrophoresis. In this chapter, we present the PEPPI-SP3 workflow, a high-resolution sample prefractionat...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Takemori A", "Kline JT", "Fornelli L", "Takemori N" ]
Takemori A
Takemori N
[ "Proteomics", "Mass Spectrometry", "Electrophoresis, Polyacrylamide Gel", "Workflow", "Proteins", "Chromatography, Liquid", "Proteome" ]
[ "Journal Article" ]
3018
null
199-209
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542531/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542530
10.1007/978-1-0716-5166-7_12
Combining SDS-PAGE with Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Top-Down Proteomics Analysis of Intact Histone Proteoforms
Mass spectrometry (MS)-based top-down proteomics (TDP) analysis of histone proteoforms provides critical information about combinatorial posttranslational modifications (PTMs), which is vital for pursuing a better understanding of epigenetic regulation of gene expression. Sodium dodecyl-sulfate polyacrylamide gel elect...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Fang F", "Sun L" ]
Fang F
Sun L
[ "Histones", "Proteomics", "Tandem Mass Spectrometry", "Electrophoresis, Capillary", "Electrophoresis, Polyacrylamide Gel", "Protein Processing, Post-Translational", "Animals", "Cattle" ]
[ "Journal Article" ]
3018
null
185-198
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542530/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542528
10.1007/978-1-0716-5166-7_10
Enrichment and Metaproteomic Analysis of Lysine Acetylation in Fecal Microbiome Samples
Among the various posttranslational modifications (PTMs) found in microbiome samples, lysine acetylation is known to be abundant and plays an important role in regulating microbial short-chain fatty acid (SCFA) metabolism. The latter is a crucial microbiome function that significantly impacts human intestinal health. T...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Zhang X", "Ning Z", "Figeys D" ]
Zhang X
Figeys D
[ "Acetylation", "Humans", "Lysine", "Proteomics", "Feces", "Protein Processing, Post-Translational", "Proteome", "Microbiota", "Gastrointestinal Microbiome" ]
[ "Journal Article" ]
3018
null
155-168
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542528/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542527
10.1007/978-1-0716-5166-7_9
Mapping Cellular Protein Lysine Methylation Using Targeted-Mass Spectrometry
Lysine methylation is a dynamic posttranslation modification (PTM) involved in the regulation of numerous biological processes. Depending on the context, site- and state-specific lysine methylation has been shown to regulate key features of proteins, such as stability, activity, and interactions. Assessing site- and st...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Chopra A", "Hoekstra M", "Willmore WG", "Biggar KK" ]
Chopra A
Biggar KK
[ "Lysine", "Humans", "Methylation", "Protein Processing, Post-Translational", "Mass Spectrometry", "Immunoprecipitation", "Proteomics" ]
[ "Journal Article" ]
3018
null
139-153
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542527/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542526
10.1007/978-1-0716-5166-7_8
Phosphoproteomics Protocol for the Identification of Novel Biomarkers from Extracellular Vesicles of Cancerous Cells
In this chapter, we describe a general sample preparation workflow for small extracellular vesicles (sEVs) from breast cancer cell lines using techniques such as protein solubilization, enzymatic digestion, and Fe3+-immobilized metal affinity chromatography (IMAC) and titanium dioxide (TiO2) enrichment prior to mass sp...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Minic Z", "Poolsup S", "Li Y", "D'Mello R", "Berezovski MV" ]
Minic Z
Berezovski MV
[ "Humans", "Proteomics", "Extracellular Vesicles", "Biomarkers, Tumor", "Chromatography, Affinity", "Titanium", "Phosphopeptides", "Phosphoproteins", "Cell Line, Tumor", "Breast Neoplasms", "Mass Spectrometry", "Female" ]
[ "Journal Article" ]
3018
null
123-137
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542526/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542525
10.1007/978-1-0716-5166-7_7
O- and N-Phosphoproteomic Analysis Using Online Alkaline-pH Reversed-Phase Nanoelectrospray-Tandem Mass Spectrometry
Protein phosphorylation (O-linked and N-linked) is associated with a wide range of biological processes and cell signaling pathways. Aberrant phosphorylation is often observed as a hallmark of diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Mass spectrometry (MS) is an indispensable to...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Wang Y", "Tang M", "Xie W" ]
Wang Y
Xie W
[ "Tandem Mass Spectrometry", "Proteomics", "Phosphoproteins", "Phosphorylation", "Spectrometry, Mass, Electrospray Ionization", "Chromatography, Reverse-Phase", "Hydrogen-Ion Concentration", "Phosphopeptides", "Humans", "Nanotechnology" ]
[ "Journal Article" ]
3018
null
111-122
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542525/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542524
10.1007/978-1-0716-5166-7_6
Endogenous Phosphopeptidomics Analysis by Using Mesoporous IMAC Materials
The analysis of endogenous phosphopeptides is crucial for identifying biomarkers of cellular signaling alterations and monitoring disease-related pathophysiological changes in vivo. While phosphoproteomics has seen remarkable progress in recent years, the field of endogenous phosphopeptidomics has lagged behind. A majo...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Wu C", "Liu B", "Ma J" ]
Wu C
Ma J
[ "Phosphopeptides", "Proteomics", "Tandem Mass Spectrometry", "Humans", "Zirconium", "Porosity", "Chromatography, High Pressure Liquid" ]
[ "Journal Article" ]
3018
null
99-109
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542524/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542521
10.1007/978-1-0716-5166-7_3
Decoding the SUMO Proteome: A Mass Spectrometry Workflow for Site-Specific Identification
Protein SUMOylation is a dynamic post-translational modification that regulates numerous cellular processes, including DNA repair, transcription, and proteostasis. SUMO modifiers are conjugated to lysine residues on substrate proteins via a conserved enzymatic cascade and can form diverse chain architectures that encod...
Methods Mol Biol
Methods in molecular biology (Clifton, N.J.)
2026
2,026
[ "Li C", "Thibault P" ]
Li C
Thibault P
[ "Sumoylation", "Proteome", "Protein Processing, Post-Translational", "Proteomics", "Mass Spectrometry", "Humans", "Small Ubiquitin-Related Modifier Proteins", "Workflow", "Animals" ]
[ "Journal Article" ]
3018
null
41-56
null
1064-3745
eng
https://pubmed.ncbi.nlm.nih.gov/42542521/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42542447
10.1007/s00401-026-03064-9
Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer's disease and advanced Alzheimer's disease
Alzheimer's disease (AD) is characterised by the intraneuronal aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles and by the extracellular deposition of β-amyloid (Aβ). Tau pathology restricted to the hippocampal formation is frequently observed in the elderly brain in the absence of any Aβ depositio...
Acta Neuropathol
Acta neuropathologica
2026 Aug 1
2,026
[ "Thierry M", "Leitner D", "Balcomb K", "Kavanagh T", "Tang L", "Kanshin E", "William C", "Oakley D", "Hyman B", "Ueberheide B", "Drummond E", "Wisniewski T" ]
Thierry M
Wisniewski T
[ "Humans", "Neurofibrillary Tangles", "Alzheimer Disease", "Hippocampus", "Proteomics", "Aged, 80 and over", "Female", "tau Proteins", "Male", "Aged", "Amyloid beta-Peptides", "Laser Capture Microdissection" ]
[ "Journal Article", "Comparative Study" ]
152
1
null
pmc-id: PMC13428778;
0001-6322
eng
https://pubmed.ncbi.nlm.nih.gov/42542447/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42541569
10.1007/s00203-026-05101-3
Emergence of gene associations in high-risk K. pneumoniae clones: bla(NDM-1) + bla(OXA-48-like) in ST15 and bla(VIM) + bla(NDM-1) in ST405
Immunocompromised patients, especially hematopoietic stem cell transplants (HSCT) / bone marrow transplant recipients, are at risk for colonization and infection with carbapenem-resistant Klebsiella pneumoniae (CR-KP) which is associated with increased bloodstream infections and mortality in this population. In this su...
Arch Microbiol
Archives of microbiology
2026 Aug 1
2,026
[ "Ben Hamza A", "Raddaoui A", "Frigui S", "Chebbi Y", "Achour W" ]
Ben Hamza A
Achour W
[ "beta-Lactamases", "Klebsiella pneumoniae", "Humans", "Multilocus Sequence Typing", "Klebsiella Infections", "Bacterial Proteins", "Anti-Bacterial Agents", "Carbapenems", "Molecular Epidemiology", "Microbial Sensitivity Tests" ]
[ "Journal Article" ]
208
10
null
null
0302-8933
eng
https://pubmed.ncbi.nlm.nih.gov/42541569/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42541045
10.23889/ijpds.v11i5.3579
Generation Scotland - Linking all the records we can
We started a family-based genetic epidemiology study in 2006-11 which recruited 24,000 adult volunteers from 7000 families across Scotland with consent for follow-up through medical record linkage and re-contact. In 2022-25 we have recruited a further 16,000 volunteers, with consent extended to administrative records, ...
Int J Popul Data Sci
International journal of population data science
2026
2,026
[ "Buchanan D" ]
Buchanan D
Buchanan D
[ "Humans", "Scotland", "Female", "Adolescent", "Adult", "Child", "Medical Record Linkage", "Male", "Young Adult", "Middle Aged", "Surveys and Questionnaires", "Molecular Epidemiology" ]
[ "Journal Article" ]
11
5
3579
pmc-id: PMC13426767;
2399-4908
eng
https://pubmed.ncbi.nlm.nih.gov/42541045/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42540726
10.23889/ijpds.v11i5.3709
Implementing a Scalable, Secure Genomics Ingest and Processing Pipeline in a Trusted Research Environment for Dementia Research
The integration of genomics data into dementia research offers transformative potential for understanding disease mechanisms and enabling precision medicine. However, its utility is constrained by significant challenges in data sharing, privacy, standardization, and computational scale. To address these barriers, we de...
Int J Popul Data Sci
International journal of population data science
2026
2,026
[ "Saraband Moghaddam A", "Hotchkiss L", "Squires E", "Thompson S" ]
Saraband Moghaddam A
Thompson S
[ "Dementia", "Genomics", "Humans", "Computer Security", "Metadata", "Information Dissemination", "Genetic Risk Score", "Computational Biology" ]
[ "Journal Article" ]
11
5
3709
pmc-id: PMC13426568;
2399-4908
eng
https://pubmed.ncbi.nlm.nih.gov/42540726/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42539859
10.3389/fcimb.2026.1713707
Application of metagenomic next-generation sequencing as an adjunct to conventional microbiological testing for the diagnosis of infection in kidney transplant recipients
Kidney transplant recipients are highly susceptible to opportunistic and nosocomial infections that demand rapid and accurate diagnosis due to the broad and complex spectrum of pathogens. Conventional microbiological testing (CMT) is often limited, particularly when patients are already receiving antimicrobial therapy ...
Front Cell Infect Microbiol
Frontiers in cellular and infection microbiology
2026
2,026
[ "Vuth H", "Wang W", "Qin W", "Yang M", "Li Y", "Zhou Q", "Xu X", "Zhang J", "Zhao H" ]
Vuth H
Zhao H
[ "Humans", "Kidney Transplantation", "High-Throughput Nucleotide Sequencing", "Metagenomics", "Retrospective Studies", "Female", "Male", "Transplant Recipients", "Bronchoalveolar Lavage Fluid", "Middle Aged", "Adult", "Sputum", "Bacteria", "Microbiological Techniques", "Aged" ]
[ "Journal Article" ]
16
null
1713707
pmc-id: PMC13424443;
2235-2988
eng
https://pubmed.ncbi.nlm.nih.gov/42539859/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42539559
10.3389/fimmu.2026.1865927
Metabolic control of RNA methylation in rheumatoid arthritis: from synovial stress to pathogenic cellular adaptation
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovitis, invasive pannus formation, cartilage degradation, and bone erosion. Although metabolic reprogramming and epigenetic dysregulation are increasingly recognized as central features of rheumatoid arthritis, the mechanisms by w...
Front Immunol
Frontiers in immunology
2026
2,026
[ "Li S", "Wan L", "Yang J", "Wang K", "Zhang X", "Liu X" ]
Li S
Liu X
[ "Humans", "Arthritis, Rheumatoid", "RNA Methylation", "Animals", "Epitranscriptome", "Metabolic Reprogramming", "Epitranscriptomics", "Synoviocytes", "Epigenesis, Genetic", "Stress, Physiological", "Synovial Membrane" ]
[ "Journal Article", "Review" ]
17
null
1865927
pmc-id: PMC13423929;
1664-3224
eng
https://pubmed.ncbi.nlm.nih.gov/42539559/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42537048
10.1111/tpj.71066
Genomic insights into flooding tolerance of Distylium chinense in the water-level fluctuation zone of the Three Gorges Reservoir
The intensification of climate change has led to frequent extreme flooding events, which threaten plant growth and food security. Studying the molecular mechanisms underlying plant flooding resistance is crucial for germplasm improvement. Distylium chinense, a perennial shrub found in the water-level fluctuation zone o...
Plant J
The Plant journal : for cell and molecular biology
2026 Aug
2,026
[ "Xia C", "Ding B", "Zhang X", "Zhang X", "Li W", "Zeng J", "Zhao F", "Jiang S", "Deng H", "Huang M" ]
Xia C
Huang M
[ "Floods", "Plant Proteins", "Genome, Plant", "Gene Expression Regulation, Plant", "Adaptation, Physiological", "Water", "Genomics", "Stress, Physiological" ]
[ "Journal Article" ]
127
3
e71066
pmc-id: PMC13427377;
0960-7412
eng
https://pubmed.ncbi.nlm.nih.gov/42537048/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42537003
10.1093/bib/bbag410
Graph designs for deep learning-based multi-omics integration
Modern sequencing technologies can now capture multiple omic layers from the same biological system, but integrating these views into a coherent model is far from trivial. Graph-based deep learning has become an attractive strategy because it can represent complex molecular interactions and sample relationships in a fl...
Brief Bioinform
Briefings in bioinformatics
2026 May 4
2,026
[ "Alif MN", "Tanvir Ahmed K", "Baul S", "Zhang W" ]
Alif MN
Zhang W
[ "Multiomics", "Deep Learning", "Humans", "Computational Biology", "Genomics" ]
[ "Journal Article", "Review" ]
27
4
null
null
1467-5463
eng
https://pubmed.ncbi.nlm.nih.gov/42537003/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42537001
10.1093/bib/bbag406
RiSpy: a feature selection-based fingerprinting framework for accurate identification of genome-edited rice lines
The European Union (EU) enforces strict regulations on the traceability and labeling of genetically modified organisms (GMOs), including genome-edited (GE) lines produced through new genomic techniques (NGTs). Identifying GE organisms created by single nucleotide variations (SNVs) is however challenging, as a single SN...
Brief Bioinform
Briefings in bioinformatics
2026 May 4
2,026
[ "Zolfaghari A", "Fraiture MA", "Vanneste K", "Stuyts A", "Frouin J", "Meunier AC", "Deforce D", "Roosens NHC", "D'aes J" ]
Zolfaghari A
D'aes J
[ "Oryza", "Genome, Plant", "Plants, Genetically Modified", "Gene Editing", "Software", "Computational Biology", "Polymorphism, Single Nucleotide", "Whole Genome Sequencing", "Genomics", "DNA Fingerprinting" ]
[ "Journal Article" ]
27
4
null
null
1467-5463
eng
https://pubmed.ncbi.nlm.nih.gov/42537001/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42536619
10.1371/journal.pone.0353347
The quantitative proteomics analysis of multi-stage gastric mucosal lesions associated with Helicobacter pylori infection
Helicobacter pylori (H. pylori) infection is the principal etiological factor for gastric cancer (GC), which ranks as the fourth leading cause of cancer-related mortality globally. Although the Correa cascade describes the stepwise progression from chronic gastritis to intestinal-type GC, the molecular events underlyin...
PLoS One
PloS one
2026
2,026
[ "Huang X", "Ma J", "Xiao Y", "Pan J", "Xu Q", "Cao X", "Liu Y", "Yi X", "Tian F" ]
Huang X
Tian F
[ "Humans", "Helicobacter Infections", "Proteomics", "Helicobacter pylori", "Gastric Mucosa", "Stomach Neoplasms", "Female", "Gastritis, Atrophic", "Male", "Middle Aged", "Tandem Mass Spectrometry", "Protein Interaction Maps", "Proteome", "Disease Progression", "Gastritis" ]
[ "Journal Article" ]
21
7
e0353347
pmc-id: PMC13426948;
1932-6203
eng
https://pubmed.ncbi.nlm.nih.gov/42536619/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42536208
10.1007/s11033-026-12517-z
Genomic and regulatory basis of visual opsin genes in the cleaner wrasse behavior: features, expression, and enhancer mechanisms
Cleaner wrasse (Labroides dimidiatus) undergoes sex reversal to male, and the two sexes exhibit distinctive cleaning behavior mediated by vision. As a keystone cleaner species in coral reef ecosystems, this fish plays an indispensable ecological role. Yet, the visual regulatory mechanisms underlying its sex-specific cl...
Mol Biol Rep
Molecular biology reports
2026 Jul 31
2,026
[ "Zhao SY", "Luo KW", "Guo HY", "Liu D" ]
Zhao SY
Liu D
[ "Animals", "Male", "Female", "Phylogeny", "Opsins", "Gene Expression Regulation", "Perciformes", "Fish Proteins", "Sex Characteristics", "Enhancer Elements, Genetic", "Behavior, Animal", "Rod Opsins", "Genomics" ]
[ "Journal Article" ]
53
1
null
null
0301-4851
eng
https://pubmed.ncbi.nlm.nih.gov/42536208/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42536097
10.1007/s11274-026-05160-0
Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach
Safer and more efficient products and processes are current global demands that drive the field of bioprospective research. Microbial sources are the main natural alternative solutions that have contributed to this biotechnological line, with environmental fungi representing important promising forces. Particularly, th...
World J Microbiol Biotechnol
World journal of microbiology & biotechnology
2026 Jul 31
2,026
[ "da Silva MK", "da Silva RC", "de Souza Melo BM", "Cavalcante TJC", "da Silva Santos L", "E Silva JGP", "Maia VRT", "da Silva Bernardo M", "da Silva Sousa K", "da Silva AV", "de Oliveira AJ", "de Queiroz AC", "Rosa LH", "Duarte AWF" ]
da Silva MK
Duarte AWF
[ "Desert Climate", "Fungi", "Biotechnology", "Genomics", "Ecosystem", "Pigments, Biological", "Cold Temperature", "Genome, Fungal", "Ascomycota", "Melanins", "Phylogeny", "Basidiomycota" ]
[ "Journal Article", "Review" ]
42
8
null
pmc-id: PMC13427916;
0959-3993
eng
https://pubmed.ncbi.nlm.nih.gov/42536097/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42536061
10.1099/mgen.0.001808
Phylogenetic analysis of serotype 19A-sequence type (ST)2331 Streptococcus pneumoniae associated with the Pneumococcal Molecular Epidemiology Network (PMEN)34 clone predominant in Japan after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7)
Following the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), serotype 19A Streptococcus pneumoniae emerged as a major cause of paediatric pneumococcal disease in Japan. Unlike global trends, in which multidrug-resistant serotype 19A-sequence type (ST)320 predominated, serotype 19A-ST2331 became one...
Microb Genom
Microbial genomics
2026 Jul
2,026
[ "Koide S", "Nakano S", "Fujisawa T", "Ito Y", "Chang B", "Suga S", "Sugawara Y", "Akeda Y", "Sugai M" ]
Koide S
Sugai M
[ "Streptococcus pneumoniae", "Japan", "Phylogeny", "Serogroup", "Humans", "Pneumococcal Infections", "Molecular Epidemiology", "Heptavalent Pneumococcal Conjugate Vaccine", "Whole Genome Sequencing", "Anti-Bacterial Agents", "Genome, Bacterial", "Drug Resistance, Multiple, Bacterial", "Pneumo...
[ "Journal Article" ]
12
7
null
pmc-id: PMC13426510;
2057-5858
eng
https://pubmed.ncbi.nlm.nih.gov/42536061/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42535825
10.1111/1755-0998.70184
Umbilical Cord: A Non-Invasive DNA Source for Sea Turtle Genomics
High-throughput sequencing has revolutionised conservation genomics by enabling genome-wide information even in non-model species. However, obtaining non-invasive samples for genomics remains challenging in species like sea turtles, which spend most of their lives in the open ocean. In addition, traditional sampling me...
Mol Ecol Resour
Molecular ecology resources
2026 Aug
2,026
[ "Marín-Capuz G", "Abella E", "Pascual M", "Pegueroles C", "Carreras C" ]
Marín-Capuz G
Carreras C
[ "Animals", "Turtles", "DNA", "Female", "Genomics", "Umbilical Cord", "Spain", "Genotype" ]
[ "Journal Article" ]
26
6
e70184
pmc-id: PMC13426248;
1755-098X
eng
https://pubmed.ncbi.nlm.nih.gov/42535825/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42535737
10.1080/0886022X.2026.2706884
Shared genetics of IgA nephropathy and cardiometabolic diseases revealed by integrative genomic analysis
Immunoglobulin A nephropathy (IgAN), the most common primary glomerular disease and a leading cause of end-stage kidney disease (ESKD), is associated with cardiovascular and metabolic abnormalities. To explore these genetic overlaps, we integrated large-scale GWAS data from IgAN, 21 pan-vascular diseases (PVDs), 13 met...
Ren Fail
Renal failure
2026 Dec
2,026
[ "Dai L", "Chen G", "Yang Y", "Yan Y", "Zhao Q", "He N", "Xiang Y", "Li Z", "Chen Y" ]
Dai L
Chen Y
[ "Humans", "Glomerulonephritis, IGA", "Genome-Wide Association Study", "Cardiovascular Diseases", "Genomics", "Genetic Predisposition to Disease", "Immunosuppressive Agents", "Gene Expression Profiling", "Multiomics", "Metabolic Diseases" ]
[ "Journal Article" ]
48
1
2706884
null
0886-022X
eng
https://pubmed.ncbi.nlm.nih.gov/42535737/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42535640
10.1093/gbe/evag146
Comparative Proteomics Reveals Conserved and Lineage-Specific Molecular Toolkits in Lophotrochozoan Biomineralization
Animal biomineralization has evolved repeatedly, yielding diverse skeletal structures. A key question is whether this diversity stems from molecular convergence or a shared ancestral toolkit. Studying lophotrochozoans-a group with carbonate, phosphate, iron, and mixed mineralization systems-provides an ideal framework ...
Genome Biol Evol
Genome biology and evolution
2026 Jul 1
2,026
[ "Chen Y", "Li J", "Peng Z", "Lv F", "Wang Y", "Teng W", "Li C", "Zhang L" ]
Chen Y
Zhang L
[ "Animals", "Biomineralization", "Proteomics", "Phylogeny", "Invertebrates", "Proteome", "Evolution, Molecular", "Calcification, Physiologic", "Animal Shells" ]
[ "Journal Article", "Comparative Study" ]
18
7
null
pmc-id: PMC13425148;
1759-6653
eng
https://pubmed.ncbi.nlm.nih.gov/42535640/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42534899
10.3389/fcimb.2026.1833734
Dynamics of archaeal diversity and functionality in the piglet gut microbiome under common antimicrobial treatments
The gut microbiota comprises a diverse and dynamic community of microorganisms that collectively enhance host metabolism, physiology, and overall functionality. In this context, the swine archaeome remains largely underexplored despite growing evidence that archaea may greatly influence host health. Advances in high-th...
Front Cell Infect Microbiol
Frontiers in cellular and infection microbiology
2026
2,026
[ "Guitart-Matas J", "Bravo M", "Tort-Miró C", "Giler-Baquerizo N", "Fraile L", "Caldas-Ramayo Y", "Ballester M", "Migura-Garcia L" ]
Guitart-Matas J
Migura-Garcia L
[ "Animals", "Archaea", "Swine", "Metagenomics", "Gastrointestinal Microbiome", "Feces", "Metagenome", "Weaning", "Biodiversity", "Anti-Infective Agents", "Gene Expression Profiling", "Phylogeny", "Diarrhea", "Anti-Bacterial Agents" ]
[ "Journal Article" ]
16
null
1833734
pmc-id: PMC13422161;
2235-2988
eng
https://pubmed.ncbi.nlm.nih.gov/42534899/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42534826
10.7717/peerj.21568
Proteomic dynamics in endochondral ossification: insights from antler tip analysis
The antler primary growth center, located at the distal tip of the growing antler, comprises five consecutive tissue zones beneath the velvet skin. Because the outermost reserve mesenchyme contains blastema progenitor cells with multipotent differentiation capacity, antler regeneration recapitulates embryonic skeletal ...
PeerJ
PeerJ
2026
2,026
[ "Xi X", "Cao X", "Zhou Y", "Tian Z", "Hou N", "Li Z", "Zhou Z", "Li X", "Su H" ]
Xi X
Su H
[ "Animals", "Antlers", "Osteogenesis", "Deer", "Proteomics", "Proteome", "Chondrogenesis" ]
[ "Journal Article" ]
14
null
e21568
pmc-id: PMC13421809;
2167-8359
eng
https://pubmed.ncbi.nlm.nih.gov/42534826/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42533578
10.24272/j.issn.2095-8137.2025.400
Phylogeographic history of the ring distribution in Malcus flavidipes (Heteroptera: Malcidae) shaped by directional dispersal and island adaptation in the South China Sea region
The ring distribution pattern offers a unique perspective for analysing the mechanisms of species or population differentiation. The semi-closed South China Sea (SCS) region, with its islands, peninsulas, and continental margins, is ideal for studying the formation of ring distribution patterns and the evolutionary dyn...
Zool Res
Zoological research
2026 Jul 18
2,026
[ "Li YF", "Guo MQ", "Chen JH", "Ai DQ", "Li ZH", "Zhang JY", "Ye Z", "Xue HJ", "Wang SJ", "Bu WJ" ]
Li YF
Bu WJ
[ "Animals", "China", "Phylogeography", "Heteroptera", "Genetic Variation", "Islands", "Animal Distribution", "Adaptation, Physiological" ]
[ "Journal Article" ]
47
4
1253-1264
null
2095-8137
eng
https://pubmed.ncbi.nlm.nih.gov/42533578/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42533568
10.1096/fj.202504206RR
From Collapse to Active Self-Repair: Integrative Multi-Omics and Machine Learning Analysis Map the Hepatic Metabolic Adaption in Response to Simulated Spaceflight Stress
Long-term spaceflight poses substantial challenges to human physiology, with the liver being highly susceptible due to its central metabolic role. To determine whether hepatic alterations represent transient stress or sustained remodeling, we performed an integrated multi-omics analysis in a rat model simulating chroni...
FASEB J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2026 Aug 15
2,026
[ "Zhang H", "Li B", "Zou Y", "Yao F", "Su W", "Li B" ]
Zhang H
Li B
[ "Animals", "Space Flight", "Rats", "Liver", "Multiomics", "Machine Learning", "Male", "Weightlessness Simulation", "Adaptation, Physiological", "Proteomics", "Metabolomics", "Stress, Physiological", "Energy Metabolism", "Lipid Metabolism", "Rats, Sprague-Dawley" ]
[ "Journal Article" ]
40
15
e72165
pmc-id: PMC13424968;
0892-6638
eng
https://pubmed.ncbi.nlm.nih.gov/42533568/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42533411
10.1002/jgc4.70268
Development and Usability Testing of an Information Needs-Based Chatbot for Individuals With Pathogenic Variants in BRCA Genes in Korea: A Methodological Study
Korean individuals with BRCA pathogenic/likely pathogenic (P/LP) variants have limited access to genetic counseling due to shortages of genetic professionals and lack of reimbursement. Despite the growing interest in digital health interventions, few digital counseling support tools have been designed to address the di...
J Genet Couns
Journal of genetic counseling
2026 Aug
2,026
[ "Park SY", "Kim Y", "Katapodi MC", "Kim S" ]
Park SY
Kim S
[ "Humans", "Female", "Republic of Korea", "Genetic Counseling", "Genes, BRCA1", "Genes, BRCA2", "Adult", "Surveys and Questionnaires", "BRCA1 Protein" ]
[ "Journal Article" ]
35
4
e70268
pmc-id: PMC13424905;
1059-7700
eng
https://pubmed.ncbi.nlm.nih.gov/42533411/
5hnMr6g7NIBaUo2Qv
kQ3aWxbeD7LUORfBe
42545593
10.1007/s12020-026-04735-z
Time in tight range and time in range in relation to diabetic retinopathy and OCTA-derived retinal microvascular parameters in hospitalized adults with type 1 diabetes
Time in Tight Range (TITR) is physiologically closer to normoglycemia than time in range (TIR) and has been linked to microvascular risk. We aimed to evaluate associations of TITR with diabetic retinopathy (DR) and optical coherence tomography angiography (OCTA)-derived retinal parameters in adults with type 1 diabetes...
Endocrine
Endocrine
2026 Aug 3
2,026
[ "Zheng R", "Zhang C", "Sun X", "Li J", "Wang L", "Huang S", "Hou R", "Dong S", "Wu S", "Li H", "Zhang L", "Kuang B", "Zheng L", "Zhang B", "Yang C", "Kuang H" ]
Zheng R
Kuang H
[ "Humans", "Diabetes Mellitus, Type 1", "Diabetic Retinopathy", "Female", "Male", "Adult", "Continuous Glucose Monitoring", "Retrospective Studies", "Tomography, Optical Coherence", "Middle Aged", "Retinal Vessels", "Blood Glucose", "Microvessels", "Hospitalization", "Time Factors" ]
[ "Journal Article" ]
91
1
null
null
1355-008X
eng
https://pubmed.ncbi.nlm.nih.gov/42545593/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545581
10.1007/s12020-026-04733-1
Prevalence and factors associated with ultrasound-detected hepatopathy in Indian adolescents with type 1 Diabetes Mellitus
Hepatic involvement in Type 1 Diabetes Mellitus (T1DM) is increasingly recognized, with hepatopathy emerging as an important but underexplored comorbidity. Data on its prevalence and associated factors, particularly in Indian children and adolescents, remain limited. To estimate the prevalence of ultrasound-diagnosed h...
Endocrine
Endocrine
2026 Aug 3
2,026
[ "Mondkar S", "Deshpande M", "Wagle S", "Khadilkar A", "Khadilkar V" ]
Mondkar S
Khadilkar V
[ "Humans", "Adolescent", "Diabetes Mellitus, Type 1", "India", "Male", "Female", "Ultrasonography", "Cross-Sectional Studies", "Prevalence", "Child", "Risk Factors", "Liver Diseases", "Comorbidity", "Insulin Resistance" ]
[ "Journal Article" ]
91
1
null
null
1355-008X
eng
https://pubmed.ncbi.nlm.nih.gov/42545581/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545547
10.1007/s12020-026-04734-0
Association of the triglyceride glucose-Chinese visceral adiposity index with incident sarcopenia among middle-aged and older adults with diabetes: a prospective cohort study
Longitudinal association of triglyceride glucose-Chinese visceral adiposity index (TyG-CVAI) with the risk of new-onset sarcopenia in middle-aged and older adults with diabetes remains unclear. This study aimed to investigate whether baseline and cumulative TyG-CVAI is associated with incident sarcopenia risk in middle...
Endocrine
Endocrine
2026 Aug 3
2,026
[ "Chen Y", "Gao T", "Gao J", "Feng X" ]
Chen Y
Feng X
[ "Humans", "Sarcopenia", "Female", "Middle Aged", "Male", "Aged", "China", "Prospective Studies", "Triglycerides", "Blood Glucose", "Adiposity", "Intra-Abdominal Fat", "Incidence", "Diabetes Mellitus", "Risk Factors", "Longitudinal Studies", "East Asian People" ]
[ "Journal Article" ]
91
1
null
null
1355-008X
eng
https://pubmed.ncbi.nlm.nih.gov/42545547/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545501
10.1007/s00394-026-04056-x
Circadian distribution of carbohydrate intake during adolescence and association with risk markers of type 2 diabetes in adulthood-the role of chronotype
Adolescence is a critical phase characterized by temporary insulin resistance and a tendency for a later chronotype, potentially influencing the risk of developing type 2 diabetes (T2D) later in life. This study explores how morning and evening carbohydrate (CHO) intake during adolescence are prospectively related to T...
Eur J Nutr
European journal of nutrition
2026 Aug 3
2,026
[ "Jankovic N", "Schmitting S", "Perrar I", "Hohoff E", "Lesani A", "Goletzke J", "Stutz B", "Herder C", "Wudy SA", "Nöthlings U", "Alexy U" ]
Jankovic N
Alexy U
[ "Humans", "Chronotype", "Diabetes Mellitus, Type 2", "Female", "Dietary Carbohydrates", "Adolescent", "Risk Factors", "Male", "Young Adult", "Biomarkers", "Circadian Rhythm", "Child", "Insulin Resistance", "Adult", "Prospective Studies" ]
[ "Journal Article" ]
65
5
null
null
1436-6207
eng
https://pubmed.ncbi.nlm.nih.gov/42545501/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545323
10.14341/probl13659
[Regional features of the main indicators of carbohydrate metabolism in young residents of various climatic and geographical zones of residence]
Vitamin D deficiency is one of the most common endocrine disorders and plays a significant role in the pathogenesis of carbohydrate metabolism disturbances. Low serum 25(OH)D levels are associated with the development of insulin resistance, metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM). However, ...
Probl Endokrinol (Mosk)
Problemy endokrinologii
2026 Jul 22
2,026
[ "Yusupova SK", "Nishanova MS", "Yusupov KA", "Abdurazakova DS", "Mukhamedova VM", "Abdulazizhojiyeva RB", "Chartakova KK", "Juliyeva YG", "Khamidova MI", "Ismoilova SK", "Khalilova SR", "Supichakov KK" ]
Yusupova SK
Supichakov KK
[ "Humans", "Female", "Vitamin D Deficiency", "Diabetes Mellitus, Type 2", "Carbohydrate Metabolism", "Prediabetic State", "Middle Aged", "Adult", "Male", "Uzbekistan", "Insulin Resistance", "Vitamin D", "Prevalence", "Climate" ]
[ "English Abstract", "Journal Article" ]
72
3
53-59
null
0375-9660
rus
https://pubmed.ncbi.nlm.nih.gov/42545323/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545322
10.14341/probl13618
Metformin's disruption of gluconeogenesis in type 2 diabetes impairments of the cori and alanine cycles as hidden drivers of metabolic waste accumulation, NF-κBHIF-1α-mediated low-grade inflammation, and multisystem dysfunction
Gluconeogenesis, a dual-purpose pathway in type 2 diabetes mellitus (T2DM), not only synthesizes glucose but also clears metabolic waste via the Cori cycle (lactate recycling through LDH, PC, PEPCK) and Alanine cycle (nitrogen disposal via ALT, GDH, urea cycle), preventing acidosis, ROS accumulation, and ammonia toxici...
Probl Endokrinol (Mosk)
Problemy endokrinologii
2026 Jul 22
2,026
[ "Akl M", "Ahmed A" ]
Akl M
Ahmed A
[ "Metformin", "Humans", "Diabetes Mellitus, Type 2", "Inflammation", "Gluconeogenesis", "Hypoglycemic Agents", "NF-kappa B", "Animals", "Alanine", "Signal Transduction" ]
[ "Journal Article", "Review" ]
72
3
44-52
null
0375-9660
eng
https://pubmed.ncbi.nlm.nih.gov/42545322/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545221
10.3928/24748307-20260409-02
Association of Functional Health Literacy Among Patients With Type-2 Diabetes in Bangladesh: A Cross-sectional Study
Functional health literacy (FHL) plays a dynamic role in diabetes care, yet research on its implications is erratic in Bangladesh. The aim of this study was to ascertain the level of FHL among patients with type 2 diabetes (T2D) in Dhaka and its correlation with their glycemic level, lifestyle, sleep quality, and socio...
Health Lit Res Pract
Health literacy research and practice
2026 Aug
2,026
[ "Islam MM", "Hossain SB", "Rahman KM", "Sinthia MK", "Chowdhury ABMA", "Khan S" ]
Islam MM
Khan S
[ "Humans", "Female", "Cross-Sectional Studies", "Diabetes Mellitus, Type 2", "Male", "Bangladesh", "Health Literacy", "Middle Aged", "Surveys and Questionnaires", "Adult", "Aged" ]
[ "Journal Article" ]
10
3
e92-e102
null
2474-8307
eng
https://pubmed.ncbi.nlm.nih.gov/42545221/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42545141
10.14715/cmb/2026.72.4.4
Antiviral ribavirin binding to human serum albumin in diabetes and uraemia: A molecular docking study
Human Serum Albumin (HSA) is abundant plasma protein in human blood. It plays a critical role in the transport and distribution of endogenous and exogenous compounds. Protein binding affects free fraction of a drug thus affecting pharmacokinetics and therapeutic efficacy. Glycation of HSA under diabetic conditions and ...
Cell Mol Biol (Noisy-le-grand)
Cellular and molecular biology (Noisy-le-Grand, France)
2026 Apr 30
2,026
[ "Almutairi FM", "Ajmal MR" ]
Almutairi FM
Ajmal MR
[ "Humans", "Molecular Docking Simulation", "Ribavirin", "Antiviral Agents", "Protein Binding", "Binding Sites", "Serum Albumin", "Uremia", "Hydrogen Bonding", "Diabetes Mellitus", "Glycosylation", "Hydrophobic and Hydrophilic Interactions" ]
[ "Journal Article" ]
72
4
22-28
null
0145-5680
eng
https://pubmed.ncbi.nlm.nih.gov/42545141/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42544576
10.1172/JCI209808
Diabetic and ER-stressed pancreatic islet β cells are in need of some JNK removal
Pancreatic β cells regulate glucose homeostasis through insulin secretion, but nutrient overload and genetic defects can trigger ER stress and apoptosis, contributing to type 2 diabetes. Within β cells, the kinases PERK, IRE1α, and ATF6 initiate the unfolded protein response (UPR) as a result of ER stress, a process th...
J Clin Invest
The Journal of clinical investigation
2026 Aug 3
2,026
[ "Palozzi JM", "Puigserver P" ]
Palozzi JM
Puigserver P
[ "Animals", "Insulin-Secreting Cells", "Endoplasmic Reticulum Chaperone BiP", "Humans", "Mice", "Diabetes Mellitus, Type 2", "Unfolded Protein Response", "Protein Serine-Threonine Kinases", "Endoplasmic Reticulum Stress", "Heat-Shock Proteins", "JNK Mitogen-Activated Protein Kinases", "Apoptosi...
[ "Journal Article" ]
136
15
null
null
0021-9738
eng
https://pubmed.ncbi.nlm.nih.gov/42544576/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42544575
10.1172/JCI193035
JNK and p53 cause human and mouse β cell death during excessive unfolded protein response
Endoplasmic reticulum (ER) stress contributes to β cell death in both Type 1 and Type 2 diabetes (T1D and T2D). However, the molecular mechanisms driving β cell death during ER stress remain insufficiently defined, limiting development of protective therapies. GRP78, an ER chaperone, is the master regulator of unfolded...
J Clin Invest
The Journal of clinical investigation
2026 Aug 3
2,026
[ "Sharma RB", "Darko C", "Wang Y", "Castro TA", "Lama TD", "Gablaski B", "Rappa A", "Redmond D", "Kim JK", "Lee AS", "Alonso LC" ]
Sharma RB
Alonso LC
[ "Animals", "Endoplasmic Reticulum Chaperone BiP", "Unfolded Protein Response", "Insulin-Secreting Cells", "Humans", "Tumor Suppressor Protein p53", "Mice", "Heat-Shock Proteins", "Protein Serine-Threonine Kinases", "Endoplasmic Reticulum Stress", "Mice, Knockout", "Endoribonucleases", "Apopt...
[ "Journal Article" ]
136
15
null
null
0021-9738
eng
https://pubmed.ncbi.nlm.nih.gov/42544575/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42544311
10.2147/DDDT.S622972
Adverse Events Associated with Incretin-Based Therapies: A Narrative Review on Mechanisms, Clinical Management, and Risk Mitigation
Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are established therapies for obesity and type 2 diabetes mellitus, providing sustained weight reduction, improved glycaemic control, cardiovascular and renal benefits. Despite these established benefits, safety concerns remain an...
Drug Des Devel Ther
Drug design, development and therapy
2026
2,026
[ "Tobaiqy M", "Alqutub ST" ]
Tobaiqy M
Alqutub ST
[ "Humans", "Incretins", "Diabetes Mellitus, Type 2", "Glucagon-Like Peptide-1 Receptor Agonists", "Obesity", "Hypoglycemic Agents" ]
[ "Journal Article", "Review" ]
20
null
622972
pmc-id: PMC13429114;
1177-8881
eng
https://pubmed.ncbi.nlm.nih.gov/42544311/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42544002
10.59556/japi.74.1567
Imeglimin in Type 2 Diabetes Mellitus: Expert Opinions and Consensus in Indian Context
Dear Editor, We read with interest the expert consensus by Seshadri et al. on imeglimin for the management of type 2 diabetes mellitus (T2DM). The article is timely and informative, particularly in view of the increasing complexity of diabetes management in India. The debate around the novel mechanism of imeglimin, whi...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jul
2,026
[ "Duraiswamy J", "Gawari NC", "Naik T", "Deshpande TA" ]
Duraiswamy J
Deshpande TA
[ "Humans", "Diabetes Mellitus, Type 2", "India", "Hypoglycemic Agents", "Insulin Resistance", "Consensus" ]
[ "Journal Article", "Consensus Statement" ]
74
7
94
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42544002/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543995
10.59556/japi.74.1615
Continuous Glucose Monitoring-Purposes, Benefits, and Problems: A Review of the Indian Scenario
One of the global epicenters of the diabetes mellitus pandemic is India. Over the past 40 years, there has been a sharp rise in the prevalence of diabetes mellitus in India due to rapid socioeconomic development, demographic shifts, and increasing susceptibility in the Indian population. Diabetes affects 74.2 million i...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jul
2,026
[ "Kushwaha A", "Kodirekkala AN", "Saharawat A", "Jaiswal R" ]
Kushwaha A
Jaiswal R
[ "Humans", "Continuous Glucose Monitoring", "India", "Blood Glucose Self-Monitoring", "Diabetes Mellitus", "Blood Glucose", "Glycated Hemoglobin" ]
[ "Journal Article", "Review" ]
74
7
70-72
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543995/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543994
10.59556/japi.74.1511
From Clinic to Community: A Public Health Framework for Metabolic Dysfunction-associated Steatotic Liver Disease Prevention in India
India is witnessing a rapid rise in metabolic dysfunction-associated steatotic liver disease (MASLD), driven by the country's expanding population with obesity, type 2 diabetes (T2D), and other metabolic comorbidities. Despite this growing burden, structured liver disease screening is absent from routine noncommunicabl...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jul
2,026
[ "Samajdar SS", "Bandyopadhyay S", "Joshi SR" ]
Samajdar SS
Joshi SR
[ "Humans", "India", "Fatty Liver", "Public Health", "Primary Health Care", "Community Health Services", "Diabetes Mellitus, Type 2", "Non-alcoholic Fatty Liver Disease" ]
[ "Journal Article" ]
74
7
67-69
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543994/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543991
10.59556/japi.74.1605
Association of Hemoglobin-Albumin-Lymphocyte-Platelet Count (HALP) Score and Type 2 Diabetes Retinopathy
Diabetic retinopathy (DR) represents a frequent microvascular consequence of type 2 diabetes mellitus (T2DM). Both inflammatory activity and nutritional status influence its development. The hemoglobin-albumin-lymphocyte-platelet (HALP) index is a composite marker that reflects these factors and has been explored in se...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jul
2,026
[ "Kumar V", "Gururaj K", "Modi P", "Kumar S", "Balivada A", "Raj A" ]
Kumar V
Raj A
[ "Humans", "Diabetic Retinopathy", "Female", "Male", "Diabetes Mellitus, Type 2", "Middle Aged", "Cross-Sectional Studies", "Platelet Count", "Hemoglobins", "Severity of Illness Index", "ROC Curve", "Aged", "Lymphocyte Count", "Biomarkers", "Serum Albumin" ]
[ "Journal Article" ]
74
7
42-48
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543991/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543983
10.59556/japi.74.1562
The Darwinization of Diabetes
Diabetes is a dynamic disease, an ever-evolving entity. In existence for centuries, the prevalence of diabetes has increased manifold over the past few decades.1 This evolution is associated with a change in classification, clinical features, comorbidities, complications, and clinical management strategies. These chang...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jul
2,026
[ "Kalra S", "Vora A", "Tiwaskar M", "Raizada N", "Verma M", "Kapoor N" ]
Kalra S
Kapoor N
[ "Humans", "Diabetes Mellitus", "History, 19th Century", "Biological Evolution", "Selection, Genetic", "History, 20th Century" ]
[ "Journal Article", "Historical Article" ]
74
7
11-12
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543983/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543967
10.59556/japi.74.1392
Index Presentation of Diabetes Mellitus as a Hyperkinetic Movement Disorder: A Thin-veiled Entity Colloquially called Diabetic Striatopathy
Often referred to as the diabetes capital of the world, new-wave urbanization and westernization of lifestyle have rendered India vulnerable to the so-called lifestyle diseases, especially diabetes mellitus. Arguably the most characterized of diseases, diabetes somehow still has a few tricks up its sleeve. Diabetic str...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jun
2,026
[ "Agrawal BK", "Singhal K", "Sharma NK", "Sharma AA" ]
Agrawal BK
Sharma AA
[ "Humans", "Male", "Aged", "Hyperkinesis", "Diabetes Mellitus, Type 2", "Diagnosis, Differential", "Chorea", "Diabetes Complications", "Movement Disorders" ]
[ "Journal Article", "Case Reports" ]
74
6S
32-33
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543967/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543958
10.59556/japi.74.1537
Consensus Guidance for the Diagnosis and Management of Diabetic Kidney Disease: Executive Summary
Diabetic kidney disease (DKD) is becoming an increasingly common consequence of diabetes in India, where the number of affected individuals is rising at an alarming pace. The illness is often silent in its early stages, and many patients are diagnosed only when kidney damage is advanced, leading to high rates of kidney...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jul
2,026
[ "Yadav K", "Jha V", "Abraham G", "Almeida AF", "Bansal S", "Bansal SB", "Bhowmik D", "Ghosh S", "Gopalakrishnan N", "Gulati S", "Joshi SR", "Kalra S", "Kesavadev J", "Kher V", "Khullar D", "Mahajan AU", "Mohan V", "Oomman A", "Parameswaran S", "Phadke U", "Ponde CK", "Praka...
Yadav K
Wangnoo SK
[ "Humans", "Diabetic Nephropathies", "India", "Sodium-Glucose Transporter 2 Inhibitors" ]
[ "Journal Article", "Consensus Statement" ]
74
7E
e24-e29
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543958/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543954
10.59556/japi.74.1363
Expert Consensus and Physician Perspectives on a Low-dose Triple Fixed-dose Combination for Type 2 Diabetes in India
Fixed-dose combinations (FDCs), particularly sulfonylurea-based triple therapies, play a central role in managing type 2 diabetes in India. With growing focus on safety and personalization, lower-dose alternatives are gaining attention, especially for early-stage and vulnerable patients. To obtain expert consensus from...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jun
2,026
[ "Kesavadev J", "Unnikrishnan AG", "Saboo B", "George J", "Kalra S", "Sen SS", "Gadia S", "Anthuvan T" ]
Kesavadev J
Anthuvan T
[ "Humans", "Diabetes Mellitus, Type 2", "India", "Hypoglycemic Agents", "Sulfonylurea Compounds", "Cross-Sectional Studies", "Metformin", "Drug Combinations", "Consensus", "Practice Patterns, Physicians'", "Male" ]
[ "Journal Article", "Consensus Statement" ]
74
6E
e42-e47
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543954/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543953
10.59556/japi.74.1501
Beyond Time in Range: Targeting Glucose Oscillations to Transform Vascular Outcomes in Diabetes
Time in range (TIR) is now widely adopted as a metric in diabetes management, offering a dynamic improvement over HbA1c alone. However, TIR does not capture the clinically relevant burden of glucose oscillations-rhythmic, intrarange fluctuations that independently drive oxidative stress, endothelial dysfunction, and in...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jun
2,026
[ "Patankar NM", "Sanghvi SJ" ]
Patankar NM
Sanghvi SJ
[ "Humans", "Continuous Glucose Monitoring", "Blood Glucose", "Oxidative Stress", "Diabetes Mellitus", "Diabetic Angiopathies", "Postprandial Period" ]
[ "Journal Article", "Review" ]
74
6E
e39-e41
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543953/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543950
10.59556/japi.74.1506
Diabetes Distress: Identifying Prevalence and Associated Factors in Type 2 Diabetes Mellitus Patients in Western India
Type 2 diabetes mellitus (T2DM) poses a significant health burden globally, with India accounting for a large proportion of cases. Beyond physical complications, diabetes distress (DD)-the emotional and psychological strain associated with diabetes management-is increasingly recognized as a critical factor affecting pa...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jun
2,026
[ "Mitra S", "Patel P", "Muley A", "Patel R", "Kella M", "Patel K" ]
Mitra S
Patel K
[ "Humans", "Diabetes Mellitus, Type 2", "India", "Female", "Male", "Cross-Sectional Studies", "Prevalence", "Middle Aged", "Adult", "Stress, Psychological", "Aged", "Risk Factors" ]
[ "Journal Article" ]
74
6E
e25-e29
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543950/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543940
10.59556/japi.74.1507
Glucagon Agonist Therapies and Vision Loss: Balancing Promise with Prudence in India
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin therapies such as tirzepatide have transformed the management of type 2 diabetes mellitus and obesity, with expanding cardiometabolic indications and rapid market growth globally and in India. However, emerging postmarketing evidence has raised con...
J Assoc Physicians India
The Journal of the Association of Physicians of India
2026 Jun
2,026
[ "Saxena A", "Prakash A" ]
Saxena A
Prakash A
[ "Humans", "India", "Diabetes Mellitus, Type 2", "Hypoglycemic Agents", "Semaglutide", "Glucagon-Like Peptide-1 Receptor Agonists", "Glucagon-Like Peptides", "Optic Neuropathy, Ischemic", "Blindness", "Diabetic Retinopathy" ]
[ "Journal Article", "Review" ]
74
6
94-96
null
0004-5772
eng
https://pubmed.ncbi.nlm.nih.gov/42543940/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543851
10.1155/jdr/1311227
Type 2 Diabetes and Cognitive Dysfunction: Cardiorespiratory Fitness and Physical Activity Matters
Diabetes is associated with an increased risk of cognitive dysfunction. We are aimed at examining cognitive performance in people with Type 2 diabetes mellitus (T2DM) and their correlation with physical activity (PA)/fitness level and mood. A cross-sectional study involving 47 individuals with T2DM, 30 diabetes-free in...
J Diabetes Res
Journal of diabetes research
2026
2,026
[ "Rojas Vega S", "Solera-Herrera A", "Vafa R", "Acero-Moreno D", "Wahrmann V", "Scheef L" ]
Rojas Vega S
Scheef L
[ "Humans", "Diabetes Mellitus, Type 2", "Cardiorespiratory Fitness", "Middle Aged", "Cross-Sectional Studies", "Male", "Female", "Exercise", "Neuropsychological Tests", "Adult", "Aged", "Cognitive Dysfunction", "Cognition", "Exercise Test", "Processing Speed" ]
[ "Journal Article" ]
2026
1
e1311227
null
2314-6753
eng
https://pubmed.ncbi.nlm.nih.gov/42543851/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543489
10.1002/psp4.70307
Bayesian Workflow for Minimal PBPK Models: Case Study of Dapagliflozin
Numerous clinical trials (CTs) and population pharmacokinetic (PK) models have been published on dapagliflozin, an approved SGLT2 inhibitor used to treat type 2 diabetes, heart failure, and chronic kidney disease. This study proposes a Bayesian workflow for the development of minimal physiologically-based PK models (mP...
CPT Pharmacometrics Syst Pharmacol
CPT: pharmacometrics & systems pharmacology
2026 Aug
2,026
[ "Mikhailova A", "Peskov K", "Helmlinger G", "Sokolov V" ]
Mikhailova A
Sokolov V
[ "Benzhydryl Compounds", "Bayes Theorem", "Glucosides", "Humans", "Models, Biological", "Sodium-Glucose Transporter 2 Inhibitors", "Workflow", "Diabetes Mellitus, Type 2" ]
[ "Journal Article" ]
15
8
e70307
null
2163-8306
eng
https://pubmed.ncbi.nlm.nih.gov/42543489/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543379
10.19540/j.cnki.cjcmm.20260401.501
[Distribution patterns and clinical characteristics of traditional Chinese medicine syndromes in diabetic peripheral neuropathy]
Using multiple statistical methods, this study investigated the core diagnostic information from the four diagnostic methods, the distribution patterns of syndrome elements, and their relationship with laboratory biochemical indicators in diabetic peripheral neuropathy(DPN). The aim is to deepen the understanding of th...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jul
2,026
[ "Li JJ", "Liu JX", "Guo JC", "Jiang AJ", "Fang ZH", "Shen GM", "Wen WB" ]
Li JJ
Wen WB
[ "Humans", "Female", "Diabetic Neuropathies", "Male", "Medicine, Chinese Traditional", "Middle Aged", "Retrospective Studies", "Aged", "Adult", "Yin Deficiency", "Diagnosis, Differential", "Bayes Theorem", "Cluster Analysis" ]
[ "English Abstract", "Journal Article" ]
51
13
3899-3910
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543379/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543355
10.19540/j.cnki.cjcmm.20260305.702
[Roles of vascular smooth muscle cells phenotype transformation in mediating progression of diabetic macroangiopathy and current status of traditional Chinese medicine treatment]
Diabetic macroangiopathy, a major chronic complication of diabetes, is characterized by atherosclerosis. Its pathological core involves the phenotype transformation of vascular smooth muscle cells(VSMCs) towards synthesis, aging, calcification, macrophage-like and fibroblast-like phenotypes. These phenotypic transforma...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jul
2,026
[ "Liu HY", "Zhang ZH", "Zhu YJ", "Li XL", "Wang XR", "Yang C", "Xie CG" ]
Liu HY
Xie CG
[ "Humans", "Muscle, Smooth, Vascular", "Animals", "Drugs, Chinese Herbal", "Phenotype", "Diabetic Angiopathies", "Medicine, Chinese Traditional", "Myocytes, Smooth Muscle", "Disease Progression" ]
[ "Journal Article", "Review", "English Abstract" ]
51
13
3657-3665
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543355/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543317
10.19540/j.cnki.cjcmm.20260428.401
[Therapeutic effect and mechanism of Qingxin Lianzi Decoction in ameliorating diabetic kidney disease based on renal metabolomics]
Renal metabolomics and molecular biology techniques were employed to investigate the interventional effect and underlying mechanism of Qingxin Lianzi Decoction(QXLZ) in rats with diabetic kidney disease(DKD). Sprague-Dawley rats were randomly assigned to the following groups: a blank group, a model group, a metformin(0...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jun
2,026
[ "Chen J", "Bai M", "Yu RS", "Liu Y", "Su X", "Zhu XD" ]
Chen J
Zhu XD
[ "Animals", "Drugs, Chinese Herbal", "Diabetic Nephropathies", "Rats", "Rats, Sprague-Dawley", "Male", "Kidney", "Metabolomics", "Humans", "Tumor Necrosis Factor-alpha", "Blood Glucose" ]
[ "English Abstract", "Journal Article" ]
51
12
3581-3589
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543317/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543305
10.19540/j.cnki.cjcmm.20260303.801
[Study on mechanism of ultrafiltration membrane extract of Angelicae Sinensis Radix and Hedysari Radix regulates mitochondrial function to ameliorate diabetic kidney disease]
This study aims to investigate the action mechanism and target molecules of the ultrafiltration membrane extract of Angelicae Sinensis Radix and Hedysari Radix in improving renal tissue injury in rats with diabetic kidney disease(DKD) from the perspective of mitochondrial function. Ten SPF-grade male Wistar rats were s...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jun
2,026
[ "Yang R", "Jia ZQ", "Wan SF", "Wei ZH", "Hu YM" ]
Yang R
Hu YM
[ "Animals", "Male", "Rats", "Mitochondria", "Diabetic Nephropathies", "Drugs, Chinese Herbal", "Rats, Wistar", "Angelica sinensis", "Ultrafiltration", "Humans", "Kidney", "Apoptosis" ]
[ "English Abstract", "Journal Article" ]
51
12
3459-3467
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543305/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42543287
10.19540/j.cnki.cjcmm.20260206.703
[Unveiling efficacy targets and differentiated mechanisms of Colquhounia Root Tablets in "homotherapy for heteropathy" of rheumatoid arthritis and diabetic kidney disease: a analysis based on topological feature identification and path priority assessment]
Based on a strategy integrating topological feature identification and path priority assessment, this study systematically explored the efficacy targets and differentiated mechanisms of Colquhounia Root Tablets(CRT) in the "homotherapy for heteropathy" of rheumatoid arthritis(RA) and diabetic kidney disease(D...
Zhongguo Zhong Yao Za Zhi
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2026 Jun
2,026
[ "Cai BB", "Mao X", "Ma ZC", "Xu MZ", "Lin Y", "Lin N", "Zhang YQ" ]
Cai BB
Zhang YQ
[ "Animals", "Arthritis, Rheumatoid", "Diabetic Nephropathies", "Plant Roots", "Drugs, Chinese Herbal", "Humans", "Protein Interaction Maps", "Tablets" ]
[ "English Abstract", "Journal Article" ]
51
11
3284-3293
null
1001-5302
chi
https://pubmed.ncbi.nlm.nih.gov/42543287/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42542856
10.11604/pamj.2026.54.5.50512
Glycemic control and its associated factors among children and adolescents with type 1 diabetes in Ethiopia: a narrative review
Glycemic control is a critical component in the management of diabetes mellitus among children and adolescents. This narrative review synthesizes existing evidence on the status of glycemic control-both good and poor-and its associated factors among Ethiopian children and adolescents living with diabetes. The objective...
Pan Afr Med J
The Pan African medical journal
2026
2,026
[ "Leake Y", "Hagos HH", "Reta BK" ]
Leake Y
Reta BK
[ "Humans", "Ethiopia", "Adolescent", "Glycemic Control", "Diabetes Mellitus, Type 1", "Blood Glucose", "Child", "Hypoglycemic Agents", "Insulin", "Blood Glucose Self-Monitoring", "Prevalence" ]
[ "Journal Article", "Review" ]
54
null
5
pmc-id: PMC13428645;
1937-8688
eng
https://pubmed.ncbi.nlm.nih.gov/42542856/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42541639
10.1007/s12020-026-04716-2
Under-recognition of autoimmune polyendocrine syndromes in T1DM: results from an extended screening workup
Type 1 diabetes mellitus (T1DM) is frequently associated with other autoimmune disorders, particularly autoimmune thyroid disease (AITD) and celiac disease. Guidelines recommend screening for thyroid and celiac disease in T1DM patients. Nevertheless, in case of their positivity, indicating the presence of an autoimmune...
Endocrine
Endocrine
2026 Aug 1
2,026
[ "Velardi V", "Sanson L", "Toffoli B", "Favaro F", "Fischetti F", "Fabris B", "Candido R", "Bernardi S" ]
Velardi V
Bernardi S
[ "Humans", "Polyendocrinopathies, Autoimmune", "Female", "Diabetes Mellitus, Type 1", "Cross-Sectional Studies", "Male", "Adult", "Celiac Disease", "Middle Aged", "Thyroiditis, Autoimmune", "Mass Screening", "Prevalence", "Autoantibodies", "Young Adult" ]
[ "Journal Article" ]
91
1
null
pmc-id: PMC13428756;
1355-008X
eng
https://pubmed.ncbi.nlm.nih.gov/42541639/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42541619
10.1007/s10735-026-10921-0
Integrated UPLC-MS/MS profiling and network pharmacology-based analysis of the anti-hyperglycemic potential of Baihu Jia Renshen Decoction combined with Sanghuangporus vaninii extract in mice
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder requiring multi-target therapeutic strategies. Traditional Chinese medicine offers potential multi-component interventions, yet the material basis and molecular mechanisms of novel formulations often remain incompletely defined. This study developed an int...
J Mol Histol
Journal of molecular histology
2026 Aug 1
2,026
[ "Zhang J", "Chen Y", "Lin Y", "Huang Z", "Ge X", "Liu B", "Huang Z" ]
Zhang J
Huang Z
[ "Animals", "Mice", "Network Pharmacology", "Drugs, Chinese Herbal", "Hypoglycemic Agents", "Tandem Mass Spectrometry", "Male", "Chromatography, High Pressure Liquid", "Diabetes Mellitus, Experimental", "Plant Extracts", "Blood Glucose", "Glycoside Hydrolase Inhibitors", "alpha-Glucosidases" ...
[ "Journal Article" ]
57
4
null
null
1567-2379
eng
https://pubmed.ncbi.nlm.nih.gov/42541619/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42541047
10.23889/ijpds.v11i5.3570
Using Linked Administrative Health Data to Examine Maternal Preconception Diabetes and Hypertension and Child Growth in Ontario, Canada: A Longitudinal Cohort Study
Research on whether maternal diabetes and hypertension prior to conception influence their children's health is limited. In Ontario, Canada, ICES is an independent research institute that securely houses population-based administrative health data, including diagnostic information, for individuals covered under the pro...
Int J Popul Data Sci
International journal of population data science
2026
2,026
[ "Li X", "Chomka L", "Keown-Stoneman C", "Allen C", "Anderson L", "Ara Begum E", "D'Annunzio D", "Thadani S", "Maguire J", "Birken C" ]
Li X
Birken C
[ "Humans", "Female", "Longitudinal Studies", "Ontario", "Child", "Hypertension", "Child, Preschool", "Pregnancy", "Body Mass Index", "Adult", "Infant", "Child Development", "Male", "Infant, Newborn", "Diabetes Mellitus", "Pregnancy in Diabetics" ]
[ "Journal Article" ]
11
5
3570
pmc-id: PMC13426783;
2399-4908
eng
https://pubmed.ncbi.nlm.nih.gov/42541047/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42540994
10.23889/ijpds.v11i5.3492
New-onset diabetes following SARS-CoV-2 Omicron infection: a matched cohort study
Understanding the longer-term health impacts of SARS-CoV-2 infection is essential for informing public health policy. While earlier studies suggested increased diabetes risk after infection, evidence for the Omicron period and the modifying effect of vaccination remains limited and inconsistent. A matched cohort study ...
Int J Popul Data Sci
International journal of population data science
2026
2,026
[ "Qian J", "Stepien S", "Cheng A", "Newall A", "Wood J", "Rowe S", "Thompson K", "O'Donnell B", "Dore G", "Macartney K" ]
Qian J
Macartney K
[ "Humans", "COVID-19", "Female", "Adult", "Diabetes Mellitus", "Cohort Studies", "Male", "Australia", "Middle Aged", "Aged", "SARS-CoV-2", "Risk Factors", "Adolescent", "Young Adult", "COVID-19 Vaccines", "Proportional Hazards Models" ]
[ "Journal Article" ]
11
5
3492
pmc-id: PMC13426669;
2399-4908
eng
https://pubmed.ncbi.nlm.nih.gov/42540994/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42540952
10.23889/ijpds.v11i5.3567
Temporal Signals of Disease: A Transformer Approach for Predicting Diabetes from Longitudinal EHRs
To develop and evaluate a Transformer-based temporal representation learning framework for predicting incident diabetes using longitudinal laboratory data, and to compare its performance with state-of-the-art pretrained models and traditional machine-learning baselines. We deterministically linked a cardiac registry co...
Int J Popul Data Sci
International journal of population data science
2026
2,026
[ "Pan J", "Lee S", "Virani A", "Riazi K", "Martin E", "Leung A", "Quan H", "Li N" ]
Pan J
Li N
[ "Humans", "Diabetes Mellitus", "Electronic Health Records", "Longitudinal Studies", "Predictive Learning Models", "Alberta", "Boosting Machine Learning Algorithms", "Registries", "Prediction Algorithms" ]
[ "Journal Article" ]
11
5
3567
pmc-id: PMC13426693;
2399-4908
eng
https://pubmed.ncbi.nlm.nih.gov/42540952/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42540905
10.23889/ijpds.v11i5.3497
Exposure to diabetes and own diabetes status using a whole population network of the Netherlands
Diabetes is one of the most common chronic diseases in the Netherlands: approximately 1.2 million people have diabetes, of which 1.1 million have type 2 diabetes. Type 2 diabetes is strongly related to lifestyle factors (e.g. unhealthy eating habits, being overweight and smoking), but also to ageing and it has a geneti...
Int J Popul Data Sci
International journal of population data science
2026
2,026
[ "van Hedel K", "de Jonge E", "van der Laan J", "Das M" ]
van Hedel K
Das M
[ "Humans", "Netherlands", "Diabetes Mellitus, Type 2", "Female", "Middle Aged", "Adult", "Male", "Life Style", "Aged", "Social Environment", "Socioeconomic Factors" ]
[ "Journal Article" ]
11
5
3497
pmc-id: PMC13426636;
2399-4908
eng
https://pubmed.ncbi.nlm.nih.gov/42540905/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42540556
10.18176/resp.00126
Dermatological lesions in diabetes
Diabetes is a chronic metabolic disease characterised by high glucose levels and altered carbohydrate and lipid metabolism, affecting an increasing number of people worldwide. Spain ranks fifth among European countries with the highest incidence of diabetes. Hyperglycaemia causes damage to numerous cell types, includin...
Rev Esp Sanid Penit
Revista espanola de sanidad penitenciaria
2026 May-Aug
2,026
[ "Casado-Hoces SV", "González-Tejedor D", "Martín-Velasco R" ]
Casado-Hoces SV
Martín-Velasco R
[ "Humans", "Diabetes Complications", "Skin Diseases", "Diabetes Mellitus", "Insulin Resistance" ]
[ "Journal Article", "Review" ]
28
2
67-75
pmc-id: PMC13426110;
1575-0620
eng
https://pubmed.ncbi.nlm.nih.gov/42540556/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42539567
10.3389/fimmu.2026.1874841
Immune checkpoint inhibitor-induced diabetes mellitus in metastatic NSCLC: a case report with extended follow-up and management considerations
Immune checkpoint inhibitors-induced diabetes mellitus (ICI-DM) is a rare but potentially life-threatening endocrine immune-related adverse event, often characterized by abrupt onset of insulin deficiency and frequent presentation with diabetic ketoacidosis and difficulty with daily management with the available therap...
Front Immunol
Frontiers in immunology
2026
2,026
[ "Nova D", "Pagliari GG", "Mambrito S", "Cortinovis DL", "Canova S" ]
Nova D
Canova S
[ "Humans", "Immune Checkpoint Inhibitors", "Lung Neoplasms", "Carcinoma, Non-Small-Cell Lung", "Antibodies, Monoclonal, Humanized", "Diabetes Mellitus", "Male", "Insulin", "Neoplasm Metastasis", "Aged" ]
[ "Case Reports", "Journal Article" ]
17
null
1874841
pmc-id: PMC13423843;
1664-3224
eng
https://pubmed.ncbi.nlm.nih.gov/42539567/
9lRAwP1dogJpvKfy0
FC5EFQkqYJAwdCVtI
42538134
10.1111/josh.70212
Improving Pain Literacy Among Future Educators: Contemporary Pain Neuroscience Education in Teacher Preparation
Persistent pain affects approximately one in five children and adolescents globally and is associated with school absenteeism, reduced academic engagement, psychosocial distress, and long-term health consequences. Schools are important settings for developing health beliefs and self-management behaviors, yet educators ...
J Sch Health
The Journal of school health
2026 Aug
2,026
[ "Curfman SE", "Best WJ", "Harrison DA", "Austin GP", "Finch DC" ]
Curfman SE
Finch DC
[ "Humans", "Neurosciences", "Health Literacy", "School Teachers", "Health Knowledge, Attitudes, Practice", "Teacher Training", "Chronic Pain", "Pain Management", "Curriculum", "School Health Services" ]
[ "Journal Article" ]
96
8
e70212
pmc-id: PMC13427623;
0022-4391
eng
https://pubmed.ncbi.nlm.nih.gov/42538134/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42536721
10.1126/sciadv.aee8595
From trade-offs to translation: An interdisciplinary roadmap for neurotechnology
Neurotechnologies are transforming how we measure, interpret, and modulate brain-body interactions, integrating real-time sensing, computation, and stimulation to enable precise physiological control. They hold transformative potential across clinical and nonclinical domains, from treating disorders to enhancing cognit...
Sci Adv
Science advances
2026 Jul 31
2,026
[ "Serrano RR", "Troughton JG", "Mirkhani N", "Martínez N", "Mariello M", "Tsigarides J", "Williamson S", "Sapriza J", "Susnoschi Luca I", "Dominguez-Alfaro A", "Cuttaz E", "Thompson N", "Swedick S", "Almulla L", "Güemes A" ]
Serrano RR
Güemes A
[ "Humans", "Neurosciences", "Translational Research, Biomedical" ]
[ "Journal Article", "Review" ]
12
31
eaee8595
pmc-id: PMC13426423;
2375-2548
eng
https://pubmed.ncbi.nlm.nih.gov/42536721/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42529859
10.1242/dev.205924
Transitions in development - an interview with Helen Willsey
Helen Willsey is an Associate Professor at the Weill Institute for Neuroscience at the University of California, San Francisco (UCSF), USA. Helen's group uses frog models to dissect how risk genes contribute to psychiatric disorders. We spoke to Helen to learn more about her career trajectory, the importance of mentors...
Development
Development (Cambridge, England)
2026 Aug 1
2,026
[]
null
null
[ "Animals", "History, 21st Century", "History, 20th Century", "Humans", "Neurosciences", "Developmental Biology", "Mentors" ]
[ "Interview", "Historical Article" ]
153
15
null
null
0950-1991
eng
https://pubmed.ncbi.nlm.nih.gov/42529859/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42525788
10.1126/scitranslmed.aeh1718
Cancer neuroscience: Mechanisms to medicine
The nervous system is now recognized as an enabling hallmark of cancer biology. Neural inputs drive tumor growth in both central nervous system tumors and extracranial tumors through different mechanisms, including synaptic signaling, adrenergic regulation, perineural invasion, neuropeptides, immune remodeling, and bio...
Sci Transl Med
Science translational medicine
2026 Jul 29
2,026
[ "Pasvolsky L", "Jones GH", "Vu Y", "Winkler F", "Amit M" ]
Pasvolsky L
Amit M
[ "Humans", "Neoplasms", "Animals", "Neurosciences" ]
[ "Journal Article", "Review" ]
18
860
eaeh1718
null
1946-6234
eng
https://pubmed.ncbi.nlm.nih.gov/42525788/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42525784
10.1126/scitranslmed.aeg9138
The neuroscience of childhood brain cancers
Nervous system activity drives both normal neurodevelopment and childhood brain cancers through paracrine and synaptic signaling. In childhood gliomas, cancer cells integrate structurally and electrically into neural networks, and neuron-cancer interactions are strongly growth-promoting. Understanding the neuroscience ...
Sci Transl Med
Science translational medicine
2026 Jul 29
2,026
[ "Monje M" ]
Monje M
Monje M
[ "Humans", "Brain Neoplasms", "Neurosciences", "Child", "Animals", "Neurodevelopment", "Glioma", "Neurons" ]
[ "Journal Article", "Review" ]
18
860
eaeg9138
null
1946-6234
eng
https://pubmed.ncbi.nlm.nih.gov/42525784/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42522123
10.1002/cne.70190
Comparative Neuroanatomy of Hydrothermal Vent Shrimps: Ecological Differentiation Among Four Alvinocaridid Species
Alvinocaridid shrimps colonize hydrothermal vent fields along the Mid-Atlantic Ridge (MAR), where they experience extreme environmental conditions including high hydrostatic pressure, steep thermal and chemical gradients, and dim light. While various aspects of the biology of the dominant vent shrimp Rimicaris exoculat...
J Comp Neurol
The Journal of comparative neurology
2026 Aug
2,026
[ "Mathou A", "Machon J", "Meth R", "Zbinden M", "Ravaux J", "Harzsch S" ]
Mathou A
Harzsch S
[ "Animals", "Brain", "Decapoda", "Species Specificity", "Hydrothermal Vents", "Ecosystem", "Neuroanatomy" ]
[ "Journal Article", "Comparative Study" ]
534
8
e70190
pmc-id: PMC13415758;
0021-9967
eng
https://pubmed.ncbi.nlm.nih.gov/42522123/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42507815
10.1111/jep.70544
Improvement in Pain Neuroscience Knowledge and Patient Perceptions Following a One-Day Multidisciplinary Pain Education Program
Pain neuroscience education is recognized as a core component of multidisciplinary chronic pain management. Although meta-analyses report small to medium clinical benefits across a range of chronic pain conditions and delivery settings, further evidence is needed to support implementation. To evaluate changes in knowle...
J Eval Clin Pract
Journal of evaluation in clinical practice
2026 Aug
2,026
[ "Chan SH", "Davis H" ]
Chan SH
Davis H
[ "Humans", "Pain Management", "Female", "Patient Education as Topic", "Health Knowledge, Attitudes, Practice", "Male", "Neurosciences", "Middle Aged", "Adult", "Chronic Pain", "Quality Improvement", "Surveys and Questionnaires", "Aged" ]
[ "Journal Article" ]
32
5
e70544
pmc-id: PMC13405248;
1356-1294
eng
https://pubmed.ncbi.nlm.nih.gov/42507815/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42499153
10.1002/alz.71634
Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study
Studies of the oldest-old show great neuropathologic heterogeneity; little is known in diverse populations after age 90. LifeAfter90 is a lifecourse cohort study of individuals aged ≥ 90 years evaluated every 6 months with optional brain donation; this study presents initial neuropathological findings. A total of 124 d...
Alzheimers Dement
Alzheimer's & dementia : the journal of the Alzheimer's Association
2026 Jul
2,026
[ "Dugger BN", "Luu MN", "Patel V", "DeCarli C", "Jin LW", "Gilsanz P", "Mungas D", "Kawas C", "Corrada MM", "Whitmer RA" ]
Dugger BN
Whitmer RA
[ "Humans", "Aged, 80 and over", "Female", "Male", "Brain", "Cohort Studies", "Alzheimer Disease", "Hippocampal Sclerosis", "Cognitive Dysfunction", "Neuropathology" ]
[ "Journal Article" ]
22
7
e71634
pmc-id: PMC13400840;
1552-5260
eng
https://pubmed.ncbi.nlm.nih.gov/42499153/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42496772
10.1007/s12021-026-09799-w
SACS: A Reproducible, Configuration-Driven Software Framework for Schematic Multi-Region Circuit Simulation and Integrated Analytics
Computational neuroscience projects often combine simulation code, configuration files, analysis scripts, plotting utilities, and provenance records through loosely coupled and difficult-to-replay workflows. SACS is presented as a configuration-driven research-software framework for reproducible schematic multi-region ...
Neuroinformatics
Neuroinformatics
2026 Jul 24
2,026
[ "Beyene ED", "Atmaca E" ]
Beyene ED
Atmaca E
[ "Software", "Computer Simulation", "Humans", "Animals", "Brain", "Models, Neurological", "Reproducibility of Results", "Neurosciences" ]
[ "Journal Article" ]
24
3
null
null
1539-2791
eng
https://pubmed.ncbi.nlm.nih.gov/42496772/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42486689
10.1523/JNEUROSCI.0172-26.2026
My Fifty Years Thinking about Emotional Consciousness in the Brain
This piece provides an overview of my fifty-year career as a neuroscientist. I spent much of this time trying to understand what emotions are and how they relate to human behavior and consciousness. I am pleased that my work on the amygdala helped bring emotion into the field. But late in the game I changed my views ab...
J Neurosci
The Journal of neuroscience : the official journal of the Society for Neuroscience
2026 Jul 22
2,026
[ "LeDoux JE" ]
LeDoux JE
LeDoux JE
[ "Humans", "Consciousness", "Emotions", "Brain", "History, 21st Century", "History, 20th Century", "Neurosciences", "Animals" ]
[ "Journal Article", "Historical Article" ]
46
29
null
pmc-id: PMC13393538;embargo-date: 2027/01/22;
0270-6474
eng
https://pubmed.ncbi.nlm.nih.gov/42486689/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42459150
10.2196/94246
Active Ingredients in Digital Cognitive Interventions: Integrating Dismantling Designs With Mechanistic Neuroscience
Digital cognitive interventions (DCIs) have emerged as scalable approaches for treating cognitive dysfunction across psychiatric, neurological, and aging populations. Despite growing evidence of efficacy, little is known about which intervention components drive therapeutic effects or through which neurocognitive mecha...
JMIR Ment Health
JMIR mental health
2026 Jul 14
2,026
[ "Morimoto SS", "Lindbergh CA", "Conley A", "Jones DR", "Steffens DC" ]
Morimoto SS
Steffens DC
[ "Humans", "Digital Media", "Research Design", "Cognitive Dysfunction", "Neurosciences", "Cognitive Behavioral Therapy" ]
[ "Journal Article" ]
13
null
e94246
pmc-id: PMC13373463;
2368-7959
eng
https://pubmed.ncbi.nlm.nih.gov/42459150/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42455665
10.1073/pnas.2610776123
Divergent philosophical commitments in neuroscience: Evidence from a global survey
The mind-brain relationship is a foundational yet underexplored dimension of contemporary neuroscience, shaping research framing, data interpretation, and public communication. We conducted a large-scale international survey of 2,657 neuroscientists to assess their views on the mind-brain problem, free will, and the fu...
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
2026 Jul 21
2,026
[ "Navarro-Peña F", "Arrondo G", "Barrett NF", "Güell F", "Madirolas G", "Murillo JI", "Sánchez-Cañizares J", "Bernacer J" ]
Navarro-Peña F
Bernacer J
[ "Neurosciences", "Humans", "Philosophy", "Brain" ]
[ "Journal Article" ]
123
29
e2610776123
pmc-id: PMC13389498;
0027-8424
eng
https://pubmed.ncbi.nlm.nih.gov/42455665/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42444549
10.1111/nyas.70336
The Importance of Studying the Cognitive Neuroscience of Aging Across Cultures
It is now widely appreciated that culture can shape cognition and neural engagement. However, research investigating the effects of culture across the adult lifespan, with a focus on cognitive aging, is lacking. In this article, we consider why this integration of topics is useful and discuss the ways in which culture ...
Ann N Y Acad Sci
Annals of the New York Academy of Sciences
2026 Jul
2,026
[ "Gutchess A", "Tan YS", "Qian J", "Goh JOS" ]
Gutchess A
Goh JOS
[ "Humans", "Cognitive Neuroscience", "Aging", "Cognition", "Culture", "Decision Making", "Cognitive Aging", "Brain", "Memory, Long-Term", "Neurosciences" ]
[ "Journal Article", "Review" ]
1561
1
e70336
pmc-id: PMC13366456;
0077-8923
eng
https://pubmed.ncbi.nlm.nih.gov/42444549/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42431561
10.1016/j.neuroimage.2026.122095
The steady-state visual evoked potential (SSVEP): A review of applications in cognitive and clinical neuroscience and neural engineering
The steady-state visual evoked potential (SSVEP), the brain's oscillatory response to repetitive visual stimulation (RVS), has emerged as a powerful tool in neuroscience with wide-ranging applications in multiple disciplines. This review provides a scoping, narrative roadmap of SSVEP applications organized into three p...
Neuroimage
NeuroImage
2026 Sep
2,026
[ "Tsoneva T", "Desain P", "Garcia-Molina G", "Thielen J" ]
Tsoneva T
Thielen J
[ "Humans", "Evoked Potentials, Visual", "Cognitive Neuroscience", "Electroencephalography", "Brain", "Brain-Computer Interfaces" ]
[ "Journal Article", "Review" ]
338
null
122095
null
1053-8119
eng
https://pubmed.ncbi.nlm.nih.gov/42431561/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42424573
10.1212/CPJ.0000000000200642
Altered EEG in Creutzfeldt-Jakob Disease: Improving Diagnostic Accuracy Using American Clinical Neurophysiology Society 2021 Criteria
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive neurodegenerative disease characterized by significant changes in EEG and structural alterations on MRI. Both are integrated in the current World Health Organization (WHO) surveillance criteria of CJD. We aimed to re-evaluate the EEG recordings, along with clinic...
Neurol Clin Pract
Neurology. Clinical practice
2026 Aug
2,026
[ "Berger-Sieczkowski E", "Zulehner G", "Klotz S", "Regelsberger G", "Haider L", "Bonelli-Nauer S", "Trimmel K", "Gelpi E" ]
Berger-Sieczkowski E
Gelpi E
[ "Creutzfeldt-Jakob Syndrome", "Humans", "Electroencephalography", "Female", "Male", "Aged", "Middle Aged", "Societies, Medical", "Magnetic Resonance Imaging", "Neurophysiology" ]
[ "Journal Article" ]
16
4
e200642
pmc-id: PMC13352215;embargo-date: 2027/08/01;
2163-0402
eng
https://pubmed.ncbi.nlm.nih.gov/42424573/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42418303
10.1002/brb3.71491
Diagnostic Agreement and 1-Year Outcomes in Functional Neurological Disorder Following Neuroscience-Informed Assessment, Education, and Counseling: A Retrospective Cohort Study
We sought to explore outcomes at 1 year in functional neurological disorder (FND) following a neuroscience-informed education and counseling assessment. Patients with FND were assessed at a quaternary neuropsychiatry clinic in Toronto, Canada, and provided education and counseling to build insight into their FND diagno...
Brain Behav
Brain and behavior
2026 Jul
2,026
[ "Mollica A", "Ng E", "Nannapaneni S", "Bhayat U", "Feinstein A", "Perez DL", "Burke MJ" ]
Mollica A
Burke MJ
[ "Humans", "Female", "Male", "Adult", "Retrospective Studies", "Nervous System Diseases", "Middle Aged", "Counseling", "Patient Education as Topic", "Neurosciences", "Follow-Up Studies", "Conversion Disorder" ]
[ "Journal Article" ]
16
7
e71491
pmc-id: PMC13344738;
2162-3279
eng
https://pubmed.ncbi.nlm.nih.gov/42418303/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ
42418096
10.1007/s40656-026-00746-1
The ontological status of behaviour: lessons from experimental neurosis (1900-1950)
This article examines how early twentieth-century comparative psychology treated behaviour as a primary site for studying regulation, dysfunction, and adaptation, using experimental neurosis as a historical case study. Beginning with Pavlov's observation that dogs exposed to irresolvable conflict developed persistent b...
Hist Philos Life Sci
History and philosophy of the life sciences
2026 Jul 8
2,026
[ "De Marco RJ" ]
De Marco RJ
De Marco RJ
[ "Animals", "Dogs", "Behavior, Animal", "History, 20th Century", "Neurosciences", "Psychology, Comparative", "History, 19th Century" ]
[ "Journal Article", "Historical Article", "Review" ]
48
3
null
pmc-id: PMC13346283;
0391-9714
eng
https://pubmed.ncbi.nlm.nih.gov/42418096/
PIgM9m77TgVQyiyw9
E5ItlhoU1SRxvUojQ