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42504988 | 10.1002/advs.76796 | Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection | Single-atom (SA) engineering offers atomic-level control over interfacial reactivity, yet the lack of printable SA-based inks hinders its practical translation into electrochemical sensing. Here, a fully water-based inkjet-printable ink is introduced based on nitrogen-doped graphene acid (NGA) hosting atomically disper... | Adv Sci (Weinh) | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 2026 Jul 27 | 2,026 | [
"Nalepa MA",
"Panáček D",
"Hrubý V",
"Jendrišák M",
"Langer R",
"Langer M",
"Jakubec P",
"Dědek I",
"Kupka V",
"Mazur M",
"Zbořil R",
"Otyepka M"
] | Nalepa MA | Otyepka M | [] | [
"Journal Article"
] | null | null | e76796 | pmc-id: PMC13403738; | 2198-3844 | eng | https://pubmed.ncbi.nlm.nih.gov/42504988/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42424369 | 10.1371/journal.pone.0353571 | Industrialization of sandwich composite panels for portable outdoor tabletops | Sandwich composite panels offer a promising pathway for developing lightweight yet mechanically robust portable outdoor tabletops, but their industrialization outside traditional aerospace and transportation sectors remains challenging. This study investigates how sandwich composites can be adapted for mass‑market outd... | PLoS One | PloS one | 2026 | 2,026 | [
"Yu W",
"Langer R"
] | Yu W | Langer R | [] | [
"Journal Article"
] | 21 | 7 | e0353571 | pmc-id: PMC13349161; | 1932-6203 | eng | https://pubmed.ncbi.nlm.nih.gov/42424369/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42422618 | 10.7759/cureus.110432 | Invasive Paget's Disease of the Breast: A Staging Pitfall Mimicking pT4 Disease | Invasive Paget's disease of the breast is a rare entity with therapeutic challenges. Herein, we report three patients with Paget's disease of the breast with dermal invasion, of which two cases had coexistent invasive breast carcinoma, while the third had an extensive in situ component. Case 1 was a 49-year-old lady pr... | Cureus | Cureus | 2026 Jun | 2,026 | [
"Sharma A",
"Langer R",
"Chadha P",
"Gupta G",
"Singh S"
] | Sharma A | Singh S | [] | [
"Case Reports",
"Journal Article"
] | 18 | 6 | e110432 | pmc-id: PMC13343245; | 2168-8184 | eng | https://pubmed.ncbi.nlm.nih.gov/42422618/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42386722 | 10.1038/s41467-026-74918-9 | A deep learning framework for efficient pathology image analysis | Artificial intelligence has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images. However, current methods are computationally inefficient, processing thousands of redundant tiles per slide and requiring complex aggregation models. We introduce EAGLE (Efficient Approach... | Nat Commun | Nature communications | 2026 Jul 1 | 2,026 | [
"Neidlinger P",
"Lenz T",
"Foersch S",
"Loeffler CML",
"Clusmann J",
"Gustav M",
"Shaktah LA",
"Langer R",
"Dislich B",
"Boardman LA",
"French AJ",
"Goode EL",
"Gsur A",
"Brezina S",
"Gunter MJ",
"Steinfelder R",
"Behrens HM",
"Röcken C",
"Harrison T",
"Peters U",
"Phipps AI"... | Neidlinger P | Kather JN | [
"Deep Learning",
"Humans",
"Image Processing, Computer-Assisted",
"Neoplasms"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural"
] | 17 | 1 | null | pmc-id: PMC13324285; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/42386722/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42341113 | 10.1126/sciadv.aee3894 | A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness | Hydrogels that adhere to biological tissues and resist fibrosis are required to provide both optimal functionality and appropriate stiffness on diverse soft tissues to achieve therapeutic efficacy and biocompatibility. However, their performance is often limited by an intrinsic trade-off between functionality and stiff... | Sci Adv | Science advances | 2026 Jun 26 | 2,026 | [
"Yang J",
"Zhao Y",
"Jeang WJ",
"Pabel S",
"Wong BM",
"Manan R",
"Nahrendorf M",
"Langer R",
"Anderson DG"
] | Yang J | Anderson DG | [
"Animals",
"Mice",
"Hydrogels",
"Fibrosis",
"Biocompatible Materials",
"Polymers"
] | [
"Journal Article"
] | 12 | 26 | eaee3894 | pmc-id: PMC13292947; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/42341113/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42315983 | 10.1111/his.70203 | Effects of short-course preoperative endocrine therapy on tumour morphology and immunohistochemical profile in oestrogen receptor-positive, HER2-negative breast cancer | Short-term preoperative endocrine therapy (ET) is increasingly used in oestrogen receptor (ER)-positive, HER2-negative breast cancer as a functional test of endocrine sensitivity. We aimed to characterise histomorphological and immunophenotypic changes following preoperative ET and to identify predictors of endocrine r... | Histopathology | Histopathology | 2026 Jun 18 | 2,026 | [
"Grosse C",
"Grosse A",
"Noack P",
"Preuss CI",
"Schwarz HK",
"Schneeweiss B",
"Gitter T",
"Schrenk P",
"Langer R"
] | Grosse C | Langer R | [] | [
"Journal Article"
] | null | null | null | null | 0309-0167 | eng | https://pubmed.ncbi.nlm.nih.gov/42315983/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42269714 | 10.1021/acsnano.6c02090 | The Use of Deep Learning in RNA Therapeutic Development | Ribonucleic acid (RNA)-based therapeutics have emerged as promising methods of disease treatment due to their ability to target the human genome and influence protein production, their versatility, and their relative lack of toxicity compared to other gene therapies. However, the RNA therapeutic design space is extreme... | ACS Nano | ACS nano | 2026 Jun 23 | 2,026 | [
"Subramanian DA",
"Yao SL",
"Chan A",
"Witten J",
"Reker D",
"Anderson DG",
"Langer R",
"Traverso G"
] | Subramanian DA | Traverso G | [
"Deep Learning",
"Humans",
"RNA",
"Nucleic Acid Conformation",
"Genetic Therapy"
] | [
"Journal Article",
"Review"
] | 20 | 24 | 17163-17177 | null | 1936-0851 | eng | https://pubmed.ncbi.nlm.nih.gov/42269714/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42234750 | 10.1126/sciadv.aea5433 | Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine | Enteric pathogens are a major contributor to the global disease burden, necessitating vaccines capable of inducing robust gastrointestinal mucosal immunity. Achieving this response is especially challenging with inactivated or subunit vaccines, which lack the ability of live-attenuated formulations to mimic the natural... | Sci Adv | Science advances | 2026 Jun 5 | 2,026 | [
"Eshaghi B",
"Wang EY",
"Mursalova S",
"Forster TA",
"Lasrado N",
"Tian J",
"Artzi D",
"Lin SQ",
"Wu Z",
"Yang X",
"Chung W",
"Sadeghi I",
"Garcia J",
"Chen Z",
"Sheridan O",
"Das R",
"Lau A",
"Gurram A",
"Mainou BA",
"Jones KAV",
"Liu Y",
"Barouch DH",
"von Andrian U",
... | Eshaghi B | Jaklenec A | [
"Animals",
"Female",
"Rats",
"Adjuvants, Immunologic",
"Immunity, Mucosal",
"Immunization",
"Immunoglobulin A",
"Intestinal Mucosa",
"Lipids",
"Lymph Nodes",
"Nanoparticles",
"Nanovaccines",
"Poliomyelitis",
"Poliovirus Vaccine, Inactivated",
"Liposomes",
"Humans"
] | [
"Journal Article"
] | 12 | 23 | eaea5433 | pmc-id: PMC13232564; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/42234750/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42204291 | 10.1038/s41551-026-01721-8 | Author Correction: Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons | null | Nat Biomed Eng | Nature biomedical engineering | 2026 Jun | 2,026 | [
"Gu W",
"Luozhong S",
"Cai S",
"Londhe K",
"Elkasri N",
"Hawkins R",
"Yuan Z",
"Su-Greene K",
"Yin Y",
"Cruz M",
"Chang YW",
"McMullen P",
"Wu C",
"Seo C",
"Guru A",
"Gao W",
"Sarmiento T",
"Schaffer C",
"Nishimura N",
"Cerione R",
"Yu Q",
"Warden M",
"Langer R",
"Jiang... | Gu W | Jiang S | [] | [
"Published Erratum"
] | 10 | 6 | 1263 | null | 2157-846X | eng | https://pubmed.ncbi.nlm.nih.gov/42204291/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42182975 | 10.1016/j.device.2026.101084 | Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally invasive sites | Here, we develop a next-generation wireless, battery-free oxygen generating O2-Macrodevice and wearable power transfer platform that can enable long-term immune protection and subcutaneous function of therapeutic cells. We demonstrate this device supports xenogeneic islet transplantation in C57BL/6J mice evidenced by 9... | Device | Device | 2026 May 15 | 2,026 | [
"Krishnan SR",
"Bochenek MA",
"Pan J",
"Pendyala S",
"Chan SN",
"Liu C",
"Prokop E",
"Hogrebe N",
"Rios PD",
"Lopez D",
"Potdar S",
"Gumustop D",
"Her BS",
"O'Keeffe L",
"Millman JR",
"Oberholzer J",
"Langer R",
"Anderson DG"
] | Krishnan SR | Anderson DG | [] | [
"Journal Article"
] | 4 | 5 | null | pmc-id: PMC13196877;manuscript-id: NIHMS2161415;embargo-date: 2027/05/15; | 2666-9994 | eng | https://pubmed.ncbi.nlm.nih.gov/42182975/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42182160 | 10.64898/2026.05.14.725177 | Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue | Expansion revealing (ExR) elucidates cellular organization by separating proteins within dense nanostructures by 20x linear expansion, but requires fixation procedures incompatible with human pathology specimens. Here, we report ExR of pathology (ExRPath), which attains ~20 nm resolution and decrowding of such tissues,... | bioRxiv | bioRxiv : the preprint server for biology | 2026 May 15 | 2,026 | [
"Stanton AE",
"Kang J",
"Blanchard JW",
"Boix CA",
"Schroeder ME",
"Lee Y",
"Su H",
"Wang S",
"Yu E",
"Emenari A",
"Peng Z",
"Agbas E",
"Cerit O",
"Park D",
"Zhang R",
"Bennett DA",
"Yin P",
"Kellis M",
"Langer R",
"Boyden E",
"Tsai LH"
] | Stanton AE | Tsai LH | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC13192606; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/42182160/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42129506 | 10.1038/s41587-026-03115-2 | Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models | Although immunotherapy has benefited a subset of persons with cancer, its broader efficacy remains limited, primarily because of an immunosuppressive tumor microenvironment characterized by insufficient numbers of functional tumor-specific T cells, antigen-presenting cells (APCs) and tumor-infiltrating lymphocytes. Her... | Nat Biotechnol | Nature biotechnology | 2026 May 13 | 2,026 | [
"Gupta A",
"Das R",
"Reed K",
"Jeon T",
"Nguyen QTC",
"Rudra A",
"Ge X",
"Trongjit S",
"Vanrobaeys YS",
"Langer R",
"Weissleder R",
"Garris C",
"Anderson DG"
] | Gupta A | Anderson DG | [] | [
"Journal Article"
] | null | null | null | pmc-id: PMC13242704;manuscript-id: NIHMS2181530; | 1087-0156 | eng | https://pubmed.ncbi.nlm.nih.gov/42129506/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42127221 | 10.1126/scitranslmed.aeb1381 | A platform for near real-time and multiplexed monitoring of cerebrospinal fluid biomarkers and flow in neurocritical care | Real-time monitoring of cerebrospinal fluid (CSF) is critical in intensive care units for the timely management of complications such as infection and mechanical malfunction in patients with external ventricular drainage systems. Current practice relies on intermittent CSF sampling for laboratory-based biomarker analys... | Sci Transl Med | Science translational medicine | 2026 May 13 | 2,026 | [
"Keyvani F",
"Muller LM",
"Fudge N",
"MacLean B",
"Saini A",
"Khatri J",
"Kriesen T",
"Wittstock M",
"Gessler FA",
"Langer R",
"Bernstock JD",
"Srinivasan S",
"Poudineh M"
] | Keyvani F | Poudineh M | [
"Humans",
"Biomarkers",
"Critical Care",
"Biosensing Techniques",
"Hydrogen-Ion Concentration",
"Monitoring, Physiologic",
"Lactic Acid",
"Time Factors"
] | [
"Journal Article"
] | 18 | 849 | eaeb1381 | null | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/42127221/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42092613 | 10.1016/j.jconrel.2026.114980 | Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility | Microneedle (MN) devices provide a platform for development of products that can facilitate intra-and trans-dermal delivery and sampling of active pharmaceutical ingredient (APIs) and biomarkers that would otherwise be restricted by the skin barrier. Despite significant progress in the development of laboratory-based p... | J Control Release | Journal of controlled release : official journal of the Controlled Release Society | 2026 Jul 10 | 2,026 | [
"Zhou J",
"Wu L",
"Wyttenbach M",
"Lennon R",
"Liu Y",
"Christian M",
"Scherr S",
"Charara M",
"Kommalapati R",
"Blum J",
"Chatzilakou E",
"Schlueter A",
"Theobald F",
"Valenti L",
"Kosuda K",
"Jacobson GB",
"Kwon M",
"Ding S",
"Quinn C",
"Rosen C",
"Springall IC",
"Tran KT... | Zhou J | Traverso G | [
"Animals",
"Humans",
"Administration, Cutaneous",
"Biomarkers",
"Equipment Design",
"Microneedle Drug Delivery",
"Needles",
"Skin",
"Skin Absorption"
] | [
"Journal Article",
"Review",
"Research Support, Non-U.S. Gov't"
] | 395 | null | 114980 | null | 0168-3659 | eng | https://pubmed.ncbi.nlm.nih.gov/42092613/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41967811 | 10.1016/j.jconrel.2026.114914 | Cryopreservation of stem cell-derived aggregates for type 1 diabetes cell therapy: Considerations and challenges | Type 1 Diabetes (T1D) is a devastating disease in which the immune system attacks insulin- producing beta cells in the pancreas, disrupting the normal blood glucose regulation mechanism and resulting in the significant burden of ongoing blood glucose monitoring and management and longer-term damage to organs and tissue... | J Control Release | Journal of controlled release : official journal of the Controlled Release Society | 2026 Jul 10 | 2,026 | [
"Barsukova AD",
"Weng L",
"Szymanska-Vandendriessche K",
"Scott M",
"Langer R",
"Traverso G"
] | Barsukova AD | Traverso G | [
"Humans",
"Cryopreservation",
"Diabetes Mellitus, Type 1",
"Animals",
"Cryoprotective Agents",
"Stem Cells",
"Stem Cell Transplantation",
"Insulin-Secreting Cells"
] | [
"Journal Article",
"Review",
"Research Support, Non-U.S. Gov't"
] | 395 | null | 114914 | null | 0168-3659 | eng | https://pubmed.ncbi.nlm.nih.gov/41967811/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41947634 | 10.1039/d6lc90032a | Correction: Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays | Correction for 'Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays' by Ali Khademhosseini et al., Lab Chip, 2005, 5, 1380-1386, https://doi.org/10.1039/B508096G. | Lab Chip | Lab on a chip | 2026 Apr 22 | 2,026 | [
"Khademhosseini A",
"Yeh J",
"Eng G",
"Karp J",
"Kaji H",
"Borenstein J",
"Farokhzad OC",
"Langer R"
] | Khademhosseini A | Langer R | [] | [
"Published Erratum"
] | 26 | 8 | 2622 | null | 1473-0189 | eng | https://pubmed.ncbi.nlm.nih.gov/41947634/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41882132 | 10.1038/s41586-026-10221-3 | Towards intelligent and miniaturized drug delivery devices | Advances at the intersection of biotechnology, artificial intelligence, electronics and materials science are reshaping how drugs can be delivered inside the body. Intelligent and miniaturized drug delivery devices (IMDDDs) leverage these technologies to achieve precise pharmacokinetics, targeted distribution and progr... | Nature | Nature | 2026 Mar | 2,026 | [
"Wei X",
"Buse JB",
"Chen H",
"Desai TA",
"Stevens MM",
"Traverso G",
"Langer R",
"Gu Z"
] | Wei X | Gu Z | [
"Humans",
"Drug Delivery Systems",
"Miniaturization",
"Artificial Intelligence",
"Animals",
"Neoplasms",
"Cardiovascular Diseases"
] | [
"Journal Article",
"Review",
"Research Support, Non-U.S. Gov't"
] | 651 | 8107 | 897-908 | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/41882132/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41757735 | 10.1021/acsnano.5c13803 | Laser-Processed 2D Germanane on Graphene for Organohydrogel-Based Zinc-Ion Hybrid Capacitors | Group 14 monoelemental two-dimensional (2D) materials beyond graphene, such as silicene and germanene, have gained significant attention in the scientific community. Covalent functionalization of germanene with hydrogen and methyl leads to germanane (hydrogen/methyl-terminated germanene; HGe/MGe). While the optical and... | ACS Nano | ACS nano | 2026 Mar 17 | 2,026 | [
"Deshmukh S",
"Sonigara KK",
"Langer R",
"Otyepka M",
"Pumera M"
] | Deshmukh S | Pumera M | [] | [
"Journal Article"
] | 20 | 10 | 8275-8288 | pmc-id: PMC13001108; | 1936-0851 | eng | https://pubmed.ncbi.nlm.nih.gov/41757735/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41621802 | 10.1016/j.jogc.2026.103225 | Chronic Pelvic Pain in Medical Education: A Needs Assessment of British Columbian Health Care Providers in Training | Chronic pelvic pain (CPP) affects ∼15% of women and gender-diverse people, yet it is often dismissed by health care providers, partly due to a lack of related medical education. This brief communication describes the findings of a needs assessment survey for health care trainees. The findings suggest that current healt... | J Obstet Gynaecol Can | Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC | 2026 Mar | 2,026 | [
"Orr NL",
"Yang L",
"Howard AF",
"Langer R",
"Bruce B",
"Lisonek M",
"Phulka N",
"Hayward A",
"Currie L",
"Qayumi K",
"Carlyle M",
"Daudt H",
"Yong PJ"
] | Orr NL | Yong PJ | [
"Humans",
"Pelvic Pain",
"Needs Assessment",
"Chronic Pain",
"Female",
"British Columbia",
"Health Personnel",
"Education, Medical",
"Clinical Competence"
] | [
"Journal Article"
] | 48 | 3 | 103225 | null | 1701-2163 | eng | https://pubmed.ncbi.nlm.nih.gov/41621802/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41605942 | 10.1038/s41467-026-68818-1 | Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery | Lipid nanoparticles (LNPs) are the leading nonviral nucleic acid delivery technology, but LNP structure-function data remains fragmented and nonstandardized. Unlike protein engineering which is anchored by the centralized Protein Data Bank, the LNP field lacks a unified repository for systematic analysis. To address th... | Nat Commun | Nature communications | 2026 Jan 28 | 2,026 | [
"Collins E",
"Ji J",
"Kim SG",
"Witten J",
"Kim S",
"Zhu R",
"Park P",
"Jung M",
"Park A",
"Manan RS",
"Rudra A",
"Keum G",
"Bang EK",
"Jin JO",
"Jeang WJ",
"Langer R",
"Anderson DG",
"Im W"
] | Collins E | Im W | [
"Nanoparticles",
"Lipids",
"Nucleic Acids",
"Molecular Dynamics Simulation",
"Structure-Activity Relationship",
"Lipid Bilayers",
"Liposomes"
] | [
"Journal Article"
] | 17 | 1 | null | pmc-id: PMC12992592; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/41605942/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41604464 | 10.1126/scitranslmed.adt1055 | Crystallized colony-stimulating factor-1 receptor inhibitor protects immunoisolated allo but not xeno transplants in primates | Immunoisolation devices containing therapeutic protein-secreting cells offer potential for long-term therapy without immune suppression. However, scar tissue formation driven by the foreign body response (FBR) hinders nutritional exchange and ultimately leads to graft failure. We previously showed that inhibiting the c... | Sci Transl Med | Science translational medicine | 2026 Jan 28 | 2,026 | [
"Bochenek MA",
"Farah S",
"Doloff JC",
"Han HJ",
"Sadraei A",
"Jeang WJ",
"Shaheen-Mualim M",
"Kutner N",
"Odeh E",
"Facklam A",
"DiNardo A",
"Engquist EN",
"Rios P",
"Isa D",
"Ghani S",
"Joshi I",
"Xing Y",
"Wang Y",
"Pop R",
"Greiner DL",
"Oberholzer J",
"Langer R",
"An... | Bochenek MA | Anderson DG | [
"Animals",
"Humans",
"Mice, Inbred C57BL",
"Transplantation, Homologous",
"Transplantation, Heterologous",
"Receptor, Macrophage Colony-Stimulating Factor",
"Alginates",
"Insulin-Secreting Cells",
"Cytokines",
"Mice",
"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor",
"Hexuronic Ac... | [
"Journal Article"
] | 18 | 834 | eadt1055 | null | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/41604464/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41544667 | 10.1016/j.jconrel.2026.114635 | Hybrid microneedle patch for administration of measles and rubella vaccine with an on-patient medical record | Decentralized on-patient medical record (OPMR) storage would enable medical staff to access patients' medical information on demand, especially in low-resource settings lacking centralized recordkeeping infrastructure. We incorporated near-infrared (NIR) microparticles into microneedle patches (MNPs) to invisibly encod... | J Control Release | Journal of controlled release : official journal of the Controlled Release Society | 2026 Mar 10 | 2,026 | [
"Sadeqi A",
"Lee JW",
"Gomaa Y",
"Nguyen TC",
"Azizoglu E",
"Hasin T",
"Ryu YJ",
"Dixon JB",
"Kanelli M",
"Han J",
"Langer R",
"Jaklenec A",
"Prausnitz MR"
] | Sadeqi A | Prausnitz MR | [
"Animals",
"Microneedle Drug Delivery",
"Measles Vaccine",
"Guinea Pigs",
"Rubella Vaccine",
"Female",
"Antibodies, Neutralizing",
"Needles",
"Humans",
"Rats",
"Antibodies, Viral",
"Administration, Cutaneous"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, N.I.H., Extramural",
"Research Support, U.S. Gov't, P.H.S."
] | 391 | null | 114635 | null | 0168-3659 | eng | https://pubmed.ncbi.nlm.nih.gov/41544667/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41464719 | 10.3390/jcm14248817 | Endoscopic Submucosal Dissection (ESD) of Upper Gastrointestinal Carcinomas: An Integrated Clinical and Pathological Perspective | Endoscopic submucosal dissection (ESD) has revolutionized the management of early upper gastrointestinal (GI) carcinomas. While technically demanding, it offers, in experienced hands, definitive local therapy for early GI neoplasia by allowing complete En bloc resection of mucosal and superficially invasive neoplasms, ... | J Clin Med | Journal of clinical medicine | 2025 Dec 12 | 2,025 | [
"Ziachehabi A",
"Worm M",
"Liu DHW",
"Pimingstorfer P",
"Langer R"
] | Ziachehabi A | Langer R | [] | [
"Journal Article",
"Review"
] | 14 | 24 | null | pmc-id: PMC12733988; | 2077-0383 | eng | https://pubmed.ncbi.nlm.nih.gov/41464719/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41369745 | 10.1007/s00292-025-01506-x | [Biomarker testing for carcinomas of the upper gastrointestinal tract] | Predictive biomarker testing is nowadays an integral part of modern diagnostics and treatment planning for esophageal and gastric cancer. It currently consists mainly of immunohistochemically determined markers, namely the PD-L1 status (stated by the Tumor Proportion Score [TPS], Combined Positivity Score [CPS] and Tum... | Pathologie (Heidelb) | Pathologie (Heidelberg, Germany) | 2026 May | 2,026 | [
"Liu DHW",
"Piringer G",
"Köfler S",
"Langer R"
] | Liu DHW | Langer R | [
"Humans",
"Biomarkers, Tumor",
"Esophageal Neoplasms",
"Stomach Neoplasms",
"Adenocarcinoma",
"B7-H1 Antigen",
"Erb-b2 Receptor Tyrosine Kinases",
"DNA Mismatch Repair",
"Carcinoma, Squamous Cell",
"Gastrointestinal Neoplasms",
"Immunohistochemistry"
] | [
"Journal Article",
"Review",
"English Abstract"
] | 47 | 3 | 220-230 | pmc-id: PMC13109289; | 2731-7188 | ger | https://pubmed.ncbi.nlm.nih.gov/41369745/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41364662 | 10.1093/cercor/bhaf297 | Diversity of axon initial segment geometry in the mouse hippocampus and its predicted influence on neuronal excitability | Action potentials, the primary information units of the nervous system, are usually generated at the axon initial segment. Changes in the length and position of the axon initial segment are associated with alterations in neuronal excitability, but there is only limited information about the baseline structural variabil... | Cereb Cortex | Cerebral cortex (New York, N.Y. : 1991) | 2025 Nov 27 | 2,025 | [
"Stevens NA",
"Achilles M",
"Monath J",
"Langer R",
"Engelhardt M",
"Both M",
"Thome C"
] | Stevens NA | Thome C | [
"Animals",
"Male",
"Hippocampus",
"Axon Initial Segment",
"Female",
"Pyramidal Cells",
"Mice",
"Mice, Inbred C57BL",
"Action Potentials",
"Axons",
"Dendrites",
"Humans"
] | [
"Journal Article"
] | 35 | 12 | null | pmc-id: PMC12687872; | 1047-3211 | eng | https://pubmed.ncbi.nlm.nih.gov/41364662/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41354404 | 10.1016/j.jcmgh.2025.101680 | Design of CellProfiler-Based Pipelines Enabling the Attribution of Molecular Stress Markers to Specific Tissue and Subcellular Compartments of the Colonic Mucosa | Stress granules (SGs) represent membrane-free cytoplasmic structures rapidly aggregating during cellular stress responses arguably useful as markers of molecular inflammation. To provide an automated, reproducible, and unbiased analytic workflow, we used the open-source software CellProfiler to quantify SGs in distinct... | Cell Mol Gastroenterol Hepatol | Cellular and molecular gastroenterology and hepatology | 2026 | 2,026 | [
"Hödlmayr H",
"Watschinger C",
"Wallner GK",
"Knipp S",
"Rohwedder A",
"Prommer R",
"Langer R",
"Moschen AR"
] | Hödlmayr H | Moschen AR | [
"Humans",
"Intestinal Mucosa",
"RNA Recognition Motif Proteins",
"Colitis, Ulcerative",
"Biomarkers",
"RNA Helicases",
"Colon",
"Software",
"Stress Granules",
"Crohn Disease",
"DNA Helicases",
"Male",
"Epithelial Cells",
"Female",
"Stress, Physiological",
"Adult",
"Poly-ADP-Ribose Bi... | [
"Journal Article"
] | 20 | 6 | 101680 | pmc-id: PMC13094656; | 2352-345X | eng | https://pubmed.ncbi.nlm.nih.gov/41354404/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41353470 | 10.1038/s43856-025-01276-w | The critical role of food fortification in combatting malnutrition and disease susceptibility in Africa | Malnutrition can severely compromise immune function, rendering populations more vulnerable to both communicable and non-communicable diseases. Here, we discuss food fortification and micronutrient supplementation programs that have been instrumental in mitigating malnutrition across Africa and in controlling disease s... | Commun Med (Lond) | Communications medicine | 2025 Dec 6 | 2,025 | [
"Yang X",
"Zhang L",
"MacDonald S",
"Langer R",
"Jaklenec A"
] | Yang X | Jaklenec A | [] | [
"Journal Article"
] | 6 | 1 | 17 | pmc-id: PMC12789419; | 2730-664X | eng | https://pubmed.ncbi.nlm.nih.gov/41353470/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41317317 | 10.1002/2056-4538.70061 | Characterisation and impact of intratumoural stroma in melanoma and carcinoma brain metastases | Research on the tumour microenvironment in brain metastases (BM) has predominantly focused on the immune response, while the presence, morphological patterns, and potential clinical relevance of intratumoural stroma remain less intensively investigated. We retrospectively analysed 604 BM (529 carcinomas, 75 melanomas) ... | J Pathol Clin Res | The journal of pathology. Clinical research | 2026 Jan | 2,026 | [
"Bandke D",
"Weis S",
"Gruber A",
"Noack P",
"Kalev O",
"Ornig K",
"Langer R"
] | Bandke D | Langer R | [
"Humans",
"Female",
"Male",
"Brain Neoplasms",
"Middle Aged",
"Melanoma",
"Retrospective Studies",
"Aged",
"Stromal Cells",
"Tumor Microenvironment",
"Adult",
"Aged, 80 and over",
"Skin Neoplasms",
"Lung Neoplasms",
"Carcinoma"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 12 | 1 | e70061 | pmc-id: PMC12664527; | 2056-4538 | eng | https://pubmed.ncbi.nlm.nih.gov/41317317/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41284018 | 10.1007/s00292-025-01501-2 | Rare non-neoplastic gastrointestinal diseases-drugs and bugs | Rare diseases of the gastrointestinal (GI) tract present a significant diagnostic challenge. This paper focusses on two particular groups of conditions: drug-induced injuries and parasitic infections. With aging populations and increased use of complex pharmacologic regimens-including immunosuppressants and biologics-d... | Pathologie (Heidelb) | Pathologie (Heidelberg, Germany) | 2026 Jan | 2,026 | [
"Angerer L",
"Zauner T",
"Langer R"
] | Angerer L | Langer R | [
"Humans",
"Gastrointestinal Diseases",
"Rare Diseases",
"Animals",
"Diagnosis, Differential",
"Parasitic Diseases"
] | [
"Journal Article",
"Review"
] | 47 | Suppl 1 | 51-58 | pmc-id: PMC12816097; | 2731-7188 | eng | https://pubmed.ncbi.nlm.nih.gov/41284018/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41249147 | 10.1017/S0033583525100073 | Delivery of macromolecular drugs: An update | In 2019, in this journal, I discussed approaches for controlling the movement of molecules, in particular macromolecules, with an emphasis on how this enabled advances in the field of drug delivery - a field that has impacted billions of people worldwide. Since 2019, there have been advances in our work and this field ... | Q Rev Biophys | Quarterly reviews of biophysics | 2025 Nov 18 | 2,025 | [
"Langer R"
] | Langer R | Langer R | [
"Humans",
"Drug Delivery Systems",
"Macromolecular Substances",
"Nanoparticles",
"COVID-19 Vaccines",
"COVID-19",
"Animals",
"SARS-CoV-2",
"Machine Learning"
] | [
"Journal Article",
"Review",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 58 | null | e19 | null | 0033-5835 | eng | https://pubmed.ncbi.nlm.nih.gov/41249147/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41231227 | 10.1021/acsnano.5c09814 | Wafer-Scale Laser-Writing of Nanoporous Membranes with Monodisperse Pores for Robust Immunoisolation | Membranes that prevent cellular infiltration are essential components of immune-isolation devices. Stringent pore size control is critical to robustly exclude immune cells while preserving the efficient transport of nutrients and therapeutic molecules. Conventional membrane fabrication methods, however, struggle to bal... | ACS Nano | ACS nano | 2025 Dec 16 | 2,025 | [
"Montazerian H",
"Jeang WJ",
"Zhao Y",
"Manan RS",
"Bochenek MA",
"Krishnan SR",
"Langer R",
"Anderson DG"
] | Montazerian H | Anderson DG | [
"Lasers",
"Nanopores",
"Porosity",
"Particle Size",
"Animals",
"Mice",
"Membranes, Artificial",
"Surface Properties",
"Macrophages",
"Humans"
] | [
"Journal Article"
] | 19 | 49 | 41528-41539 | null | 1936-0851 | eng | https://pubmed.ncbi.nlm.nih.gov/41231227/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41203968 | 10.1038/s41565-025-02044-6 | Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines | The next generation of mRNA vaccines must address several limitations, including enhancing vaccine potency and reducing toxicity. Here we develop a class of degradable, cyclic amino ionizable lipids via sequential combinatorial chemistry and rational design. Lipid nanoparticles (LNPs) formulated with the top-performing... | Nat Nanotechnol | Nature nanotechnology | 2025 Dec | 2,025 | [
"Rudra A",
"Gupta A",
"Reed K",
"Deik A",
"Min J",
"Mansour HMA",
"Nguyen QTC",
"Danko A",
"Hu Y",
"Berger A",
"Prado M",
"Beck A",
"Clish CB",
"Klauda JB",
"Langer R",
"Anderson DG"
] | Rudra A | Anderson DG | [
"Influenza Vaccines",
"Lipids",
"Animals",
"RNA, Messenger",
"Nanoparticles",
"Mice",
"Amino Alcohols",
"mRNA Vaccines",
"Female",
"Humans",
"Mice, Inbred BALB C",
"Liposomes"
] | [
"Journal Article"
] | 20 | 12 | 1831-1842 | pmc-id: PMC13387048;manuscript-id: NIHMS2181491; | 1748-3387 | eng | https://pubmed.ncbi.nlm.nih.gov/41203968/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41127639 | 10.1021/acscatal.5c03767 | Regioselective Multiboration and Hydroboration of Alkenes and Alkynes Enabled by a Platinum Single-Atom Catalyst | Selective multiboration including di- and triboration and hydroboration of alkynes and alkenes face significant challenges in organic synthesis, including achieving high regioselectivity, functional group tolerance, and catalyst stability while requiring mild conditions to maintain reactivity. These transformations hav... | ACS Catal | ACS catalysis | 2025 Oct 17 | 2,025 | [
"Huninik P",
"Sharma P",
"Saptal VB",
"Slaby M",
"Langer R",
"Kumar P",
"Shayesteh Zeraati A",
"Wang X",
"Petr M",
"Otyepka M",
"Gawande MB",
"Zbořil R",
"Kment S",
"Walkowiak J"
] | Huninik P | Walkowiak J | [] | [
"Journal Article"
] | 15 | 20 | 17347-17360 | pmc-id: PMC12538553; | 2155-5435 | eng | https://pubmed.ncbi.nlm.nih.gov/41127639/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41109558 | 10.1016/j.jconrel.2025.114338 | Enhanced macromolecule bioavailability in rats and pigs using an in situ forming synthetic epithelial lining | Oral delivery of macromolecules is hindered by enzymatic degradation, poor epithelial permeability, and rapid gastric transit, leading to low bioavailability. Existing permeation enhancers (PEs), such as salcaprozate sodium and sodium caprate, improve absorption but do not fully address proteolytic degradation and requ... | J Control Release | Journal of controlled release : official journal of the Controlled Release Society | 2025 Dec 10 | 2,025 | [
"Kanelli M",
"Yu AC",
"Susilo D",
"Petropulos O",
"Kadasia K",
"Sandoval L",
"Hudson MA",
"Sim D",
"Dial C",
"Mena MB",
"Liang J",
"Rivera-Delgado E",
"Sepich L",
"Hollfelder K",
"Wright J",
"von Erlach T",
"Hayward A",
"Gaspie KA",
"Barron SM",
"Pombo M",
"Basani RR",
"Lan... | Kanelli M | Traverso G | [
"Animals",
"Biological Availability",
"Rats, Sprague-Dawley",
"Male",
"Swine",
"Intestinal Mucosa",
"Administration, Oral",
"Rats",
"Polymers",
"Drug Delivery Systems",
"Intestinal Absorption",
"Indoles"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 388 | Pt 2 | 114338 | pmc-id: PMC13078412;manuscript-id: NIHMS2153351; | 0168-3659 | eng | https://pubmed.ncbi.nlm.nih.gov/41109558/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41105712 | 10.1073/pnas.2511596122 | Engineered 3D immuno-glial-neurovascular human miBrain model | Patient-specific, human-based cellular models integrating a biomimetic blood-brain barrier, immune, and myelinated neuron components are critically needed to enable accelerated, translationally relevant discovery of neurological disease mechanisms and interventions. To construct a human cell-based model that includes t... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2025 Oct 21 | 2,025 | [
"Stanton AE",
"Bubnys A",
"Agbas E",
"James B",
"Park DS",
"Jiang A",
"Pinals RL",
"Liu L",
"Truong N",
"Loon A",
"Staab C",
"Cerit O",
"Wen HL",
"Mankus D",
"Bisher ME",
"Lytton-Jean AKR",
"Kellis M",
"Blanchard JW",
"Langer R",
"Tsai LH"
] | Stanton AE | Tsai LH | [
"Humans",
"Neuroglia",
"Induced Pluripotent Stem Cells",
"Neurons",
"Coculture Techniques",
"Brain",
"Blood-Brain Barrier",
"Alzheimer Disease",
"Cell Differentiation",
"Astrocytes",
"Models, Biological",
"Oligodendroglia"
] | [
"Journal Article"
] | 122 | 42 | e2511596122 | pmc-id: PMC12557797; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/41105712/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41065810 | 10.1007/s00292-025-01473-3 | [Combined gastric and respiratory heterotopia in the rectum suggesting malignancy] | Heterotopia refers to the presence of normal cells or tissue located in anatomically unusual sites of the body. In the gastrointestinal tract, most heterotopic lesions do not cause any symptoms, but rarely, they can be mistaken for neoplasms during endoscopic examinations. A 45-year-old man presented with lower abdomin... | Pathologie (Heidelb) | Pathologie (Heidelberg, Germany) | 2026 Feb | 2,026 | [
"Siegl N",
"Langer R",
"Ziachehabi A",
"Noack P"
] | Siegl N | Noack P | [
"Humans",
"Male",
"Choristoma",
"Middle Aged",
"Gastric Mucosa",
"Rectal Diseases",
"Diagnosis, Differential",
"Respiratory Mucosa",
"Salivary Glands",
"Rectal Neoplasms",
"Rectum"
] | [
"Journal Article",
"Case Reports",
"English Abstract"
] | 47 | 1 | 60-62 | pmc-id: PMC12852206; | 2731-7188 | ger | https://pubmed.ncbi.nlm.nih.gov/41065810/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41040406 | 10.1101/2025.09.26.678918 | Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease | Blood-brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD), yet the endothelial gene-regulatory programs involved remain incompletely understood. We integrate postmortem human single-nucleus transcriptomics with iPSC-based BBB models to define a conserved, inflammation-driven pathway that com... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Sep 27 | 2,025 | [
"Pinals RL",
"Islam MR",
"King O",
"Choi A",
"Kang E",
"Nakano M",
"Tuyéras A",
"Naomi MT",
"Ngo A",
"Jiang A",
"Truong N",
"Agbas E",
"Lozano Cruz CF",
"Staab C",
"Ko T",
"Bennett DA",
"Stanton AE",
"Langer R",
"Tsai LH"
] | Pinals RL | Tsai LH | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12485894; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41040406/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41034516 | 10.1038/s41551-025-01516-3 | Benchmarking foundation models as feature extractors for weakly supervised computational pathology | Numerous pathology foundation models have been developed to extract clinically relevant information. There is currently limited literature independently evaluating these foundation models on external cohorts and clinically relevant tasks to uncover adjustments for future improvements. Here we benchmark 19 histopatholog... | Nat Biomed Eng | Nature biomedical engineering | 2026 Jun | 2,026 | [
"Neidlinger P",
"El Nahhas OSM",
"Muti HS",
"Lenz T",
"Hoffmeister M",
"Brenner H",
"van Treeck M",
"Langer R",
"Dislich B",
"Behrens HM",
"Röcken C",
"Foersch S",
"Truhn D",
"Marra A",
"Saldanha OL",
"Kather JN"
] | Neidlinger P | Kather JN | [
"Humans",
"Benchmarking",
"Neoplasms",
"Computational Biology",
"Algorithms",
"Female",
"Prognosis"
] | [
"Journal Article"
] | 10 | 6 | 1113-1123 | pmc-id: PMC13279263; | 2157-846X | eng | https://pubmed.ncbi.nlm.nih.gov/41034516/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41034460 | 10.1038/s43588-025-00885-8 | Self-driving labs for biotechnology | null | Nat Comput Sci | Nature computational science | 2025 Nov | 2,025 | [
"Collins E",
"Langer R",
"Anderson DG"
] | Collins E | Anderson DG | [] | [
"Journal Article"
] | 5 | 11 | 976-979 | null | 2662-8457 | eng | https://pubmed.ncbi.nlm.nih.gov/41034460/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
41000798 | 10.1101/2025.09.18.676925 | Vascular-Perfusable Human 3D Brain-on-Chip | Development and delivery of treatments for neurological diseases are limited by the tight and selective human blood-brain barrier (BBB). Although animal models have been important research and preclinical tools, the rodent BBB exhibits species differences and fails to capture the complexity of human genetics. Microphys... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Sep 25 | 2,025 | [
"Stanton AE",
"Pinals RL",
"Choi A",
"Truong N",
"Kang E",
"Jiang A",
"Lozano Cruz CF",
"Hawkins S",
"Sarcar R",
"Volkova A",
"King O",
"Agbas E",
"Nakano M",
"Chiu CC",
"Bubnys A",
"Wright S",
"Staab C",
"Bikdash R",
"Forden E",
"Langer R",
"Tsai LH"
] | Stanton AE | Tsai LH | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12458943; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41000798/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40963020 | 10.1038/s41586-025-09537-3 | Engineered prime editors with minimal genomic errors | Prime editors make programmed genome modifications by writing new sequences into extensions of nicked DNA 3' ends1. These edited 3' new strands must displace competing 5' strands to install edits, yet a bias towards retaining the competing 5' strands hinders efficiency and can cause indel errors2. Here we discover that... | Nature | Nature | 2025 Oct | 2,025 | [
"Chauhan VP",
"Sharp PA",
"Langer R"
] | Chauhan VP | Langer R | [
"Gene Editing",
"INDEL Mutation",
"CRISPR-Associated Protein 9",
"CRISPR-Cas Systems",
"Deoxyribonuclease I",
"Humans",
"Genome",
"DNA",
"Genomics"
] | [
"Journal Article",
"Research Support, U.S. Gov't, Non-P.H.S.",
"Research Support, N.I.H., Extramural"
] | 646 | 8087 | 1254-1260 | pmc-id: PMC12571883; | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/40963020/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40957415 | 10.1016/j.cell.2025.08.027 | Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines | Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, and Bacillus Calmette-Guérin (BCG) remains the only clinically approved vaccine. An enduring challenge in TB vaccine development is systematic antigen selection from a large repertoire of potential candidates. We performed an efficacy sc... | Cell | Cell | 2025 Nov 26 | 2,025 | [
"Vidal SJ",
"Lasrado N",
"Tostanoski LH",
"Chaudhari J",
"Mbiwan ER",
"Neka GD",
"Strutton EA",
"Espinosa Perez AA",
"Sellers D",
"Barrett J",
"Lifton M",
"Wakabayashi S",
"Eshaghi B",
"Borducchi EN",
"Aid M",
"Li W",
"Scriba TJ",
"Jaklenec A",
"Langer R",
"Barouch DH"
] | Vidal SJ | Barouch DH | [
"Tuberculosis Vaccines",
"Animals",
"Humans",
"Antigens, Bacterial",
"Mice",
"Mycobacterium tuberculosis",
"Tuberculosis",
"CD4-Positive T-Lymphocytes",
"Female",
"Mice, Inbred C57BL",
"Cross Reactions",
"BCG Vaccine",
"Vaccine Development"
] | [
"Journal Article"
] | 188 | 24 | 6791-6803.e13 | pmc-id: PMC12445596;manuscript-id: NIHMS2110632; | 0092-8674 | eng | https://pubmed.ncbi.nlm.nih.gov/40957415/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40886460 | 10.1016/j.jconrel.2025.114170 | Corrigendum to "Poly(ethylene oxide)-modified poly(β-amino Ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery" [Journal of Controlled Release, 86 (2003) 223-234] | null | J Control Release | Journal of controlled release : official journal of the Controlled Release Society | 2025 Nov 10 | 2,025 | [
"Potineni A",
"Lynn DM",
"Langer R",
"Amiji MM"
] | Potineni A | Amiji MM | [] | [
"Published Erratum"
] | 387 | null | 114170 | null | 0168-3659 | eng | https://pubmed.ncbi.nlm.nih.gov/40886460/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40856212 | 10.1002/anie.202508985 | Monomer-Dependent Selectivity in Sulfur-Containing Ring-Opening Copolymerisation: Bimetallic Catalysis for Predictive Design of Degradable Polymers | Sulfur-containing polymers offer unique opportunities for advanced materials due to their inherent degradability, high refractive indices, and potential for chemical recyclability. Yet, synthetic strategies for their precise construction remain underdeveloped and monomer selection rules to achieve this are elusive. Her... | Angew Chem Int Ed Engl | Angewandte Chemie (International ed. in English) | 2025 Oct 13 | 2,025 | [
"Manjunatha BR",
"Sengoden M",
"Stühler MR",
"Langer R",
"Darensbourg DJ",
"Plajer AJ"
] | Manjunatha BR | Plajer AJ | [] | [
"Journal Article"
] | 64 | 42 | e202508985 | pmc-id: PMC12518690; | 1433-7851 | eng | https://pubmed.ncbi.nlm.nih.gov/40856212/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40841714 | 10.1007/s00428-025-04224-0 | Survival outcomes after systemic treatment of high-grade triple-negative metaplastic breast cancer versus triple-negative breast cancer of no special type | This study aimed to evaluate the prognostic impact of adjuvant and neoadjuvant chemotherapy (ACT, NACT) in high-grade triple-negative metaplastic breast cancer (TNMBC) and to compare survival outcomes with those of triple-negative breast cancer of no special type (TNBC NST). A total of 73 patients with high-grade TNMBC... | Virchows Arch | Virchows Archiv : an international journal of pathology | 2025 Aug 22 | 2,025 | [
"Grosse C",
"Grosse A",
"Schwarz HK",
"Frauchiger-Heuer H",
"Rordorf T",
"Ring A",
"Langer R",
"Varga Z"
] | Grosse C | Varga Z | [] | [
"Journal Article"
] | null | null | null | null | 0945-6317 | eng | https://pubmed.ncbi.nlm.nih.gov/40841714/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40822231 | 10.1016/j.eats.2025.103566 | Arthroscopic Transosseous Rotator Cuff Repair Using Bone Tunneling Device | Rotator cuff injuries are a common cause of shoulder pain, primarily affecting individuals older than 40 years, with the incidence increasing progressively with age. Advancements in surgical techniques have led to the development of arthroscopic techniques. This evolution has transitioned through various arthroscopic s... | Arthrosc Tech | Arthroscopy techniques | 2025 Jul | 2,025 | [
"Hudeček F",
"Apostolopoulos V",
"Kužma J",
"Liskay J",
"Langer R",
"Tomáš T"
] | Hudeček F | Tomáš T | [] | [
"Journal Article"
] | 14 | 7 | 103566 | pmc-id: PMC12350226; | 2212-6287 | eng | https://pubmed.ncbi.nlm.nih.gov/40822231/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40821760 | 10.1016/j.jtauto.2025.100305 | T-cell immunity in the experimental autoimmune vasculitis rat model | ANCA-vasculitis (AAV) is a small-vessel vasculitis characterized by the presence of autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO). The dynamics of the T-cell response within tissues is studied best in animal models. It was the aim to analyze the lesional T-cell dynamics in the experimental autoimmu... | J Transl Autoimmun | Journal of translational autoimmunity | 2025 Dec | 2,025 | [
"Zeng Y",
"Boschmann E",
"Kotte J",
"Sun M",
"Hess L",
"Dolff S",
"Hinkeldein T",
"Hagedorn J",
"Langer R",
"van Paassen P",
"Damoiseaux J",
"Cohen Tervaert JW",
"Witzke O",
"Kribben A",
"Wilde B"
] | Zeng Y | Wilde B | [] | [
"Journal Article"
] | 11 | null | 100305 | pmc-id: PMC12356024; | 2589-9090 | eng | https://pubmed.ncbi.nlm.nih.gov/40821760/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40783382 | 10.1038/s41467-025-62413-6 | Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation | Gastrointestinal (GI) dysmotility and associated conditions affect over 20% of population, yet pharmacological, behavioural, and surgical interventions offer limited therapeutic efficacy. Targeted electrical stimulation addressing underlying neuromuscular pathology stands to transform our ability to treat dysmotility. ... | Nat Commun | Nature communications | 2025 Aug 10 | 2,025 | [
"Srinivasan S",
"Antonini MJ",
"Alshareef A",
"Sahasrabudhe A",
"Jenkins J",
"Ishida K",
"Kuosmanen J",
"Hayward A",
"Min S",
"Langer R",
"Anikeeva P",
"Traverso G"
] | Srinivasan S | Traverso G | [
"Animals",
"Swine",
"Gastrointestinal Motility",
"Peristalsis",
"Electric Stimulation",
"Gastrointestinal Tract",
"Neural Prostheses",
"Enteric Nervous System",
"Myenteric Plexus",
"Electric Stimulation Therapy",
"Esophagus",
"Female"
] | [
"Journal Article"
] | 16 | 1 | 7374 | pmc-id: PMC12335536; | 2041-1723 | eng | https://pubmed.ncbi.nlm.nih.gov/40783382/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40781261 | 10.1038/s41598-025-13214-w | Clinical and pathological features of lymphomas in the breast: a comprehensive multicentric study | Breast lymphomas, though rare, present a unique spectrum of clinical and pathological characteristics. This multicenter retrospective study evaluates 92 cases from four international institutions over a ten-year period to provide a comprehensive analysis of primary breast lymphomas (PBLs), secondary breast lymphomas (S... | Sci Rep | Scientific reports | 2025 Aug 8 | 2,025 | [
"Maccio U",
"Rets A",
"Grosse C",
"Ferguson NA",
"Langer R",
"Bühler MM",
"Gallo A",
"Witzel I",
"Beham-Schmid C",
"Wieler J",
"Orsaria M",
"Varga Z"
] | Maccio U | Varga Z | [
"Humans",
"Female",
"Aged",
"Middle Aged",
"Breast Neoplasms",
"Retrospective Studies",
"Adult",
"Aged, 80 and over",
"Lymphoma",
"Lymphoma, Large-Cell, Anaplastic",
"Breast Implants",
"Prognosis"
] | [
"Journal Article",
"Multicenter Study"
] | 15 | 1 | 29032 | pmc-id: PMC12334564; | 2045-2322 | eng | https://pubmed.ncbi.nlm.nih.gov/40781261/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
40634646 | 10.1038/s41551-025-01436-2 | Emergency delivery of particulate drugs by active ejection using in vivo wireless devices | Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycaemia, anaphylaxis and cardiac arrest. Devices that automate emergency delivery, such as pumps and automated injectors, are limited by the low stability of liquid formulations. In contrast, dry... | Nat Biomed Eng | Nature biomedical engineering | 2026 Jan | 2,026 | [
"Krishnan SR",
"O'Keeffe L",
"Rudra A",
"Gumustop D",
"Khatib N",
"Liu C",
"Yang J",
"Wang A",
"Bochenek MA",
"Lu YC",
"Bose S",
"Reed K",
"Langer R",
"Anderson DG"
] | Krishnan SR | Anderson DG | [
"Animals",
"Mice",
"Drug Delivery Systems",
"Wireless Technology",
"Epinephrine",
"Glucagon",
"Male",
"Mice, Inbred C57BL",
"Diabetes Mellitus, Experimental"
] | [
"Journal Article"
] | 10 | 1 | 144-160 | pmc-id: PMC13120775;manuscript-id: NIHMS2156373; | 2157-846X | eng | https://pubmed.ncbi.nlm.nih.gov/40634646/ | MentO54PEbYHJaHuv | dy1RmDkr6StK7xc1X |
42486050 | 10.1016/j.vaccine.2026.128938 | mRNA-LNP hepatitis C vaccine encoding p7 elicits improved humoral immunogenicity | Nucleoside-modified messenger RNA lipid nanoparticle (mRNA-LNP) vaccines have had a tremendous impact on vaccine development against infectious pathogens, particularly since the onset of the COVID-19 pandemic. The platform is an effective stimulator of humoral and cellular immune responses due to unique features of the... | Vaccine | Vaccine | 2026 Jul 22 | 2,026 | [
"Reagan EK",
"Wright DA",
"Clark KE",
"Mercado-Lopez X",
"Atochina-Vasserman EN",
"Ni H",
"Mui BL",
"Hu F",
"Bailey JR",
"Bar KJ",
"Weissman D"
] | Reagan EK | Weissman D | [] | [
"Journal Article"
] | 88 | null | 128938 | null | 0264-410X | eng | https://pubmed.ncbi.nlm.nih.gov/42486050/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42446053 | 10.1002/adma.73721 | Lipid Nanoparticle Co-Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy | Oral squamous cell carcinoma (OSCC) represents 90% of all head and neck cancers. Despite decades of research, the 5-year survival rate is 50%. Strikingly, the overall incidence rate is projected to increase by 30% in the next 10 years, which may result in a sharp increase in mortality. Two fundamental aspects of OSCC a... | Adv Mater | Advanced materials (Deerfield Beach, Fla.) | 2026 Jul 14 | 2,026 | [
"Padilla MS",
"Li JJ",
"Zhang Q",
"Patwari K",
"Shi S",
"Yamagata HM",
"Joseph RA",
"Hymms BN",
"Teerdhala SV",
"Fitzgerald E",
"Chalom OZ",
"Gupta K",
"Alameh MG",
"Weissman D",
"Le AD",
"Mitchell MJ"
] | Padilla MS | Mitchell MJ | [] | [
"Journal Article"
] | null | null | e73721 | null | 0935-9648 | eng | https://pubmed.ncbi.nlm.nih.gov/42446053/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42418483 | 10.1073/pnas.2525718123 | mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity | mRNA-based cancer vaccines offer a modular and safe platform to elicit antitumor immunity, yet their efficacy is often limited by inefficient mRNA delivery and inadequate dendritic cell (DC) activation, both of which are essential for initiating robust cytotoxic T cell responses. Inadequate innate immune activation cou... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2026 Jul 14 | 2,026 | [
"Zeng Y",
"Xu J",
"Wang J",
"Xue L",
"Liu J",
"Geisler HC",
"Ma X",
"Melamed JR",
"Shi Q",
"Padilla MS",
"Luo Z",
"Zhu J",
"Thatte AS",
"Figueroa-Espada CG",
"Ang MJY",
"Murray AM",
"Yamagata HM",
"Kim D",
"Metzloff AE",
"Weissman D",
"Mitchell MJ"
] | Zeng Y | Mitchell MJ | [
"Cancer Vaccines",
"Animals",
"Membrane Proteins",
"Mice",
"Dendritic Cells",
"Nanoparticles",
"RNA, Messenger",
"STING Protein",
"Lipids",
"cGAS-STING Signaling Pathway",
"Nanovaccines",
"Female",
"Mice, Inbred C57BL",
"Humans",
"Antigens, Neoplasm",
"Cell Line, Tumor",
"Antigen Pre... | [
"Journal Article"
] | 123 | 28 | e2525718123 | pmc-id: PMC13367780;embargo-date: 2027/01/08; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/42418483/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42380659 | 10.1038/s41586-026-10838-4 | Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies | Efficient priming of B cell precursors is a rate-limiting step in the induction of V2 apex broadly neutralizing antibodies (bNAbs)1,2. Here, we describe a novel germline-targeted HIV-1 Env (CAP256.OPT4) that increases the efficiency of V2 apex bNAb precursor priming by 30-400 fold compared with wild-type HIV-1 Envs and... | Nature | Nature | 2026 Jun 30 | 2,026 | [
"Marchitto L",
"Wagh K",
"Roark RS",
"Coleon S",
"Li H",
"Skelly AN",
"Hogarty MP",
"Habib R",
"Ding W",
"Ayyanathan K",
"Liu W",
"Sheng Z",
"Guo Y",
"Bal J",
"Smith LM",
"Sutherland LL",
"Park Y",
"Connell AJ",
"Bibollet-Ruche F",
"Lewis E",
"Plante SJ",
"Akeley MJ",
"Lo... | Marchitto L | Shaw GM | [] | [
"Journal Article"
] | null | null | null | null | 0028-0836 | eng | https://pubmed.ncbi.nlm.nih.gov/42380659/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42341085 | 10.1126/scitranslmed.aeb4878 | IgA is necessary and sufficient to prevent norovirus infection in mice | Human norovirus is the leading cause of viral gastroenteritis, yet effective vaccines and therapeutics remain elusive. Using murine norovirus as a model, we found that mucosal immunoglobulin A (IgA) is both necessary and sufficient for protection against infection, whereas CD8+ T cells are dispensable. Robust intestina... | Sci Transl Med | Science translational medicine | 2026 Jun 24 | 2,026 | [
"Ökten AB",
"Filler RB",
"Kung JL",
"Fang Z",
"McWilliams BC",
"Muscat-Rivera JE",
"Kegel MS",
"Olivi Gomes IM",
"Mankowski MC",
"Skelly AN",
"Melamed JR",
"Nice TJ",
"Lee S",
"Baldridge MT",
"Smith TJ",
"Wobus CE",
"Eisenbarth SC",
"Williams A",
"Serebryannyy LA",
"Douek DC",
... | Ökten AB | Wilen CB | [
"Animals",
"Norovirus",
"Caliciviridae Infections",
"Immunoglobulin A",
"Mice",
"Humans",
"CD8-Positive T-Lymphocytes",
"Mice, Inbred C57BL",
"Antibodies, Viral",
"Immunoglobulin G"
] | [
"Journal Article"
] | 18 | 855 | eaeb4878 | null | 1946-6234 | eng | https://pubmed.ncbi.nlm.nih.gov/42341085/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42327930 | 10.1021/acsnanoscienceau.5c00170 | Decoupling Physisorption from Chemisorption in Clickable Lipid Nanoparticles | Antibody conjugation is essential for targeted lipid nanoparticle (LNP) delivery, but here we show that click-chemistry produces artifacts that confound accurate measurement of covalent antibody-LNP bonding. We demonstrate that hydrophobic interactions between the most common click alkyne linker, dibenzocyclooctyne (DB... | ACS Nanosci Au | ACS nanoscience Au | 2026 Jun 17 | 2,026 | [
"Brysgel TV",
"Hood ED",
"Milosavljevic A",
"Marzolini N",
"Zamora ME",
"Wu J",
"Shuvaev VV",
"Shuvaeva T",
"Kegel M",
"Muscat-Rivera J",
"Weissman D",
"Melamed JR",
"Myerson JW",
"Brenner JS",
"Muzykantov VR",
"Nong J"
] | Brysgel TV | Nong J | [] | [
"Journal Article"
] | 6 | 3 | 348-356 | pmc-id: PMC13281171; | 2694-2496 | eng | https://pubmed.ncbi.nlm.nih.gov/42327930/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42301768 | 10.1080/21645515.2026.2686510 | Preventive and therapeutic efficacy of mRNA/LNP vaccines encoding HPV16 E6 and E7 in an early-intervention HPV tumor mouse models | Persistent infection with high-risk human papillomavirus (HPV) drives the development of cervical and other anogenital cancers, with limited therapeutic options for early-stage disease and precancerous lesions. There is a critical unmet need for effective therapeutic vaccines capable of inducing durable immune response... | Hum Vaccin Immunother | Human vaccines & immunotherapeutics | 2026 Dec | 2,026 | [
"Saithong S",
"Prompetchara E",
"Ketloy C",
"Khawsang C",
"Tharakhet K",
"Kaewpang P",
"Yostrerat N",
"Wangsoontorn P",
"Charsangbong K",
"Lam K",
"Heyes J",
"Weissman D",
"Ruxrungtham K"
] | Saithong S | Ruxrungtham K | [
"Animals",
"Oncogene Proteins, Viral",
"Papillomavirus E7 Proteins",
"Repressor Proteins",
"Female",
"Papillomavirus Vaccines",
"Disease Models, Animal",
"Papillomavirus Infections",
"Mice",
"Vaccines, Synthetic",
"Nanoparticles",
"RNA, Messenger",
"T-Lymphocytes",
"Nanovaccines",
"mRNA ... | [
"Journal Article"
] | 22 | 1 | 2686510 | pmc-id: PMC13274139; | 2164-5515 | eng | https://pubmed.ncbi.nlm.nih.gov/42301768/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42272981 | 10.1002/btm2.70138 | Bioinspired oxidized mRNA lipid nanoparticles for ex vivo engineering of chimeric antigen receptor macrophages targeting solid tumors | Solid tumors remain difficult to treat via conventional and novel therapeutic strategies. Immunotherapies such as chimeric antigen receptor T (CAR-T) cell therapy have been remarkably effective in treating hematological cancers, but their efficacy is limited in solid tumors. Recently, CAR macrophages (CAR-Ms) have emer... | Bioeng Transl Med | Bioengineering & translational medicine | 2026 May | 2,026 | [
"Mukalel AJ",
"Tylek T",
"Geisler HC",
"O'Brien E",
"Frazee C",
"Li J",
"Thatte AS",
"Safford HC",
"Figueroa-Espada CG",
"Alameh MG",
"Hamilton AG",
"Mai D",
"Sheppard NC",
"June CH",
"Weissman D",
"Spiller KL",
"Mitchell MJ"
] | Mukalel AJ | Mitchell MJ | [] | [
"Journal Article"
] | 11 | 3 | e70138 | pmc-id: PMC13247429; | 2380-6761 | eng | https://pubmed.ncbi.nlm.nih.gov/42272981/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42263787 | 10.1016/j.jaci.2026.05.023 | Antigen-specific messenger RNA lipid nanoparticle therapy with mTOR inhibition promotes regulatory T cells and limits allergy | Immune tolerance in allergic diseases is associated with attenuation of TH2 responses by shifting of antigen-specific immunity toward TH1 and regulatory T-cell pathways, but current strategies incompletely induce durable regulatory immunity. We determined whether combining an allergen-encoded messenger RNA (mRNA) lipid... | J Allergy Clin Immunol | The Journal of allergy and clinical immunology | 2026 Jun 9 | 2,026 | [
"Rochman Y",
"Melamed JR",
"Klingler AM",
"Kotliar M",
"Rochman M",
"Caldwell JM",
"Felton JM",
"Osswald GA",
"Muscat-Rivera J",
"Kegel M",
"Barski A",
"Lewkowich IP",
"Weissman D",
"Rothenberg ME"
] | Rochman Y | Rothenberg ME | [] | [
"Journal Article"
] | null | null | null | null | 0091-6749 | eng | https://pubmed.ncbi.nlm.nih.gov/42263787/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42258728 | 10.1073/pnas.2536870123 | mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model | The unyielding antigenic drift of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as the threat of future zoonotic sarbecovirus spillovers, has prompted the search for broadly neutralizing antibodies (bNAbs) to inform rational therapeutic and vaccine design. Here, we isolated and characterized 20 ... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2026 Jun 16 | 2,026 | [
"Skelly AN",
"Fan C",
"Keeffe JR",
"Ökten AB",
"Gavor E",
"Newby ML",
"Allen JD",
"Kreider EF",
"Ding W",
"Osbaldeston RA",
"Park Y",
"Connell AJ",
"Lituchy MG",
"Bibollet-Ruche F",
"Radford KM",
"P West A Jr",
"Peña-Hernández MA",
"Cruickshank K",
"Liu W",
"Li Y",
"Albertus ... | Skelly AN | Hahn BH | [
"Animals",
"SARS-CoV-2",
"COVID-19",
"Mice",
"Antibodies, Viral",
"Antibodies, Neutralizing",
"Humans",
"Epitopes",
"Spike Glycoprotein, Coronavirus",
"RNA, Messenger",
"Disease Models, Animal"
] | [
"Journal Article"
] | 123 | 24 | e2536870123 | pmc-id: PMC13268366;manuscript-id: NIHMS2182547; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/42258728/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42190011 | 10.1073/pnas.2528144123 | Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo | mRNA-based gene editing therapeutics offer the potential to permanently cure diseases but are hindered by suboptimal delivery platforms. Here, we devise a robust combinatorial chemistry for the plug-and-play assembly of structurally diverse biodegradable ionizable lipids from amines/thiols and dialkyl maleates. After s... | Proc Natl Acad Sci U S A | Proceedings of the National Academy of Sciences of the United States of America | 2026 Jun 2 | 2,026 | [
"Han X",
"Xu Y",
"Ricciardi AS",
"Xu J",
"Xiang Y",
"Palanki R",
"Chowdhary V",
"Xue L",
"Gong N",
"Alameh MG",
"Peranteau WH",
"Wilson JM",
"Reker D",
"Weissman D",
"Mitchell MJ"
] | Han X | Mitchell MJ | [
"Animals",
"Lipids",
"RNA, Messenger",
"Gene Editing",
"Mice",
"Nanoparticles",
"Gene Transfer Techniques",
"Humans",
"Structure-Activity Relationship",
"Liposomes"
] | [
"Journal Article"
] | 123 | 22 | e2528144123 | pmc-id: PMC13229237;embargo-date: 2026/11/26; | 0027-8424 | eng | https://pubmed.ncbi.nlm.nih.gov/42190011/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42102231 | 10.1126/sciimmunol.aec3436 | In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Selective in vivo reprogramming of cytotoxic effector CD8 T (Teff) cells holds tremendous promise as a therapeutic tool but has not yet been accomplished. Here, we demonstrate that fractalkine-conjugated mRNA lipid nanoparticles (mRNA-LNPs) can specifically target and deliver mRNA to CX3CR1+ Teff cells in vitro and in ... | Sci Immunol | Science immunology | 2026 May 8 | 2,026 | [
"Corrigan AR",
"Ngiow SF",
"Statzu M",
"Albertus A",
"Pampena MB",
"Nordin JML",
"Carro SD",
"Harper J",
"Stammen RL",
"Wood J",
"Ni H",
"Su J",
"Hajialyani M",
"Shuvaev VV",
"Alcalde V",
"Ali MA",
"Hamilton JT",
"Ramalingam R",
"Wu VH",
"Paiardini M",
"Weissman D",
"Wherry... | Corrigan AR | Betts MR | [
"Animals",
"RNA, Messenger",
"Humans",
"Mice",
"Chemokine CX3CL1",
"Macaca mulatta",
"Nanoparticles",
"L-Selectin",
"T-Lymphocytes, Cytotoxic",
"Mice, Inbred C57BL",
"CD8-Positive T-Lymphocytes",
"Liposomes"
] | [
"Journal Article"
] | 11 | 119 | eaec3436 | null | 2470-9468 | eng | https://pubmed.ncbi.nlm.nih.gov/42102231/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42096521 | 10.1126/science.aec6396 | Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design | A major obstacle confronting HIV-1 vaccine and cure research is the lack of an outbred animal model for rapid and consistent induction of broadly neutralizing antibodies (bNAbs). We designed an epitope-focused simian-human immunodeficiency virus (SHIV.5MUT) that elicited broad and potent V3-glycan-targeted antibodies w... | Science | Science (New York, N.Y.) | 2026 Jun 18 | 2,026 | [
"Skelly AN",
"Gristick HB",
"Li H",
"Gavor E",
"Connell AJ",
"Kreider EF",
"Marchitto L",
"Hogarty MP",
"Newby ML",
"Allen JD",
"Liu W",
"West AP Jr",
"Ayyanathan K",
"Campion MS",
"Winters K",
"Gordon CG",
"Osbaldeston RA",
"Akeley MJ",
"Lewis E",
"Li Y",
"Singh A",
"Cruic... | Skelly AN | Shaw GM | [
"Animals",
"Humans",
"AIDS Vaccines",
"Broadly Neutralizing Antibodies",
"env Gene Products, Human Immunodeficiency Virus",
"Epitopes",
"HIV Antibodies",
"HIV Infections",
"HIV-1",
"Macaca mulatta",
"Simian Immunodeficiency Virus",
"Vaccine Development"
] | [
"Journal Article"
] | 392 | 6804 | eaec6396 | pmc-id: PMC13308464;manuscript-id: NIHMS2174568; | 0036-8075 | eng | https://pubmed.ncbi.nlm.nih.gov/42096521/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42043256 | 10.3390/v18040467 | Effect of Acid-Stabilizing Hemagglutinin Mutations on Immunogenicity and Heterologous Protection by H1N1 Influenza Virus mRNA-LNP Vaccines | While current influenza vaccines often lack broad protection against antigenically drifted strains, some modified hemagglutinin (HA) protein antigens have shown promise in eliciting broadly neutralizing antibodies against conserved epitopes. During infection, the mildly acidic environment of the late endosome triggers ... | Viruses | Viruses | 2026 Apr 15 | 2,026 | [
"Ojha CR",
"Rovito SW",
"Banoth B",
"Kim H",
"Jones JC",
"Alameh MG",
"Chen PL",
"Webby RJ",
"Weissman D",
"Russell CJ"
] | Ojha CR | Russell CJ | [
"Animals",
"Hemagglutinin Glycoproteins, Influenza Virus",
"Influenza Vaccines",
"Antibodies, Viral",
"Mice",
"Antibodies, Neutralizing",
"Influenza A Virus, H1N1 Subtype",
"Immunogenicity, Vaccine",
"Orthomyxoviridae Infections",
"Mutation",
"Female",
"Mice, Inbred BALB C",
"Nanovaccines",
... | [
"Journal Article"
] | 18 | 4 | null | pmc-id: PMC13119996; | 1999-4915 | eng | https://pubmed.ncbi.nlm.nih.gov/42043256/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
42016867 | 10.1002/btm2.70114 | Investigating the impact of hypoxia and syncytialization on lipid nanoparticle-mediated mRNA delivery to placental cells | Placental dysfunction leads to pregnancy-related disorders that affect up to 15% of pregnancies. Several of these, such as preeclampsia, are symptomatically managed but have no curative treatments other than preterm delivery. Placental dysfunction arises from improper placental development, leading to restricted blood ... | Bioeng Transl Med | Bioengineering & translational medicine | 2026 Mar | 2,026 | [
"Young RE",
"Vijayakumar T",
"Reilley LJ",
"Darji K",
"Patel D",
"Hofbauer S",
"Alameh MG",
"Weissman D",
"Riley R"
] | Young RE | Riley R | [] | [
"Journal Article"
] | 11 | 2 | e70114 | pmc-id: PMC13093655; | 2380-6761 | eng | https://pubmed.ncbi.nlm.nih.gov/42016867/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41916134 | 10.1016/j.biopha.2026.119300 | Combining CRISPR/Cas9-mediated TRAC knockout with mRNA-based CAR expression enables flexible generation of allogeneic CAR T cells | Autologous chimeric antigen receptor (CAR) T-cell therapies have demonstrated remarkable efficacy in hematologic malignancies but remain limited by complex manufacturing processes. Allogeneic, off-the-shelf CAR T cells derived from healthy donors represent a promising alternative; however, safe implementation requires ... | Biomed Pharmacother | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2026 May | 2,026 | [
"Buakaew T",
"Thaiwong R",
"Inthanachai T",
"Palaga T",
"Weissman D",
"Suppipat K",
"Ausavarungnirun C",
"Tawinwung S"
] | Buakaew T | Tawinwung S | [
"Humans",
"RNA, Messenger",
"CRISPR-Cas Systems",
"T-Lymphocytes",
"Cryopreservation",
"Receptors, Chimeric Antigen",
"Immunotherapy, Adoptive",
"Receptors, Antigen, T-Cell",
"Cell Survival",
"Gene Knockout Techniques",
"Transfection"
] | [
"Journal Article"
] | 198 | null | 119300 | null | 0753-3322 | eng | https://pubmed.ncbi.nlm.nih.gov/41916134/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41894505 | 10.1126/sciadv.adv1554 | One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development | There have been rapid advances in nucleoside-modified messenger RNA-based vaccines, particularly during the SARS-CoV-2 pandemic, demonstrating a rapid and cost-effective approach for addressing infectious diseases. A major challenge remains in developing a delivery system that protects mRNA from degradation and facilit... | Sci Adv | Science advances | 2026 Mar 27 | 2,026 | [
"Ona NA",
"Zhang D",
"Lindesmith LC",
"Park WJ",
"Meshanni JA",
"Berkihiser S",
"Vasserman JA",
"Toshtzar S",
"Moore NC",
"Williams B",
"Nakagawa B",
"Baboo I",
"Pan L",
"Cheng W",
"Mercado-López X",
"Bonilla-Acosta W",
"Brewer-Jensen PD",
"Zweigart MR",
"Reyes YI",
"Mallory ML... | Ona NA | Atochina-Vasserman EN | [
"Dendrimers",
"Animals",
"RNA, Messenger",
"Humans",
"SARS-CoV-2",
"COVID-19 Vaccines",
"COVID-19",
"Vaccine Development",
"mRNA Vaccines",
"Nanoparticles",
"Mice"
] | [
"Journal Article"
] | 12 | 13 | eadv1554 | pmc-id: PMC13025126; | 2375-2548 | eng | https://pubmed.ncbi.nlm.nih.gov/41894505/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41873855 | 10.1021/jacs.6c00080 | Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity | Lipid nanoparticles (LNPs) have been immensely successful in facilitating the delivery of nucleic acids to tissues of interest and continue to be optimized for mRNA delivery. These vehicles are particularly advantageous for vaccination due to their ease of production, highly tunable composition, and ability to induce r... | J Am Chem Soc | Journal of the American Chemical Society | 2026 Apr 8 | 2,026 | [
"Yamagata HM",
"Padilla MS",
"Hamilton AG",
"Swingle KL",
"Thatte AS",
"Ricciardi AS",
"Agrawal A",
"Fitzgerald E",
"Poirier AJ",
"Geisler HC",
"Joseph RA",
"Chalom OZ",
"Du S",
"Li JJ",
"Kim D",
"Whitaker RC",
"Figueroa-Espada CG",
"Han EL",
"Murray AM",
"Alameh MG",
"Weissm... | Yamagata HM | Mitchell MJ | [
"Animals",
"Nanoparticles",
"Lipids",
"Mice",
"Liver",
"Lymph Nodes",
"RNA, Messenger",
"COVID-19 Vaccines",
"Humans",
"SARS-CoV-2",
"COVID-19",
"Mice, Inbred C57BL",
"Liposomes"
] | [
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 148 | 13 | 14137-14150 | null | 0002-7863 | eng | https://pubmed.ncbi.nlm.nih.gov/41873855/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41867765 | 10.64898/2026.03.03.709287 | Preventing Disease Emergence Following Eradication: Application to Mpox | We use simple mathematical models to explore the factors that influence the evolutionary emergence of mpox to a pathogen capable of sustained human to human transmission that poses a global threat. Smallpox eradication followed by the discontinuation of immunization with vaccinia has led to a decline in the level of po... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Mar 4 | 2,026 | [
"Hirst C",
"Deichmann J",
"Saha A",
"Longini I",
"Handel A",
"Lipsitch M",
"Weissman D",
"Antia R"
] | Hirst C | Antia R | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC13001426; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41867765/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41851499 | 10.1038/s41565-025-02102-z | Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy | Regulating T cell phenotypes between activation and exhaustion remains a significant challenge for messenger RNA-based cancer immunotherapy. A potential approach to improve anti-cancer T cell activity is to co-deliver interleukin-12 (IL-12), to stimulate effector T cells, and indoleamine 2,3-dioxygenase (IDO) inhibitor... | Nat Nanotechnol | Nature nanotechnology | 2026 Mar | 2,026 | [
"Shi Q",
"Gong N",
"Wang J",
"Palanki R",
"Zheng Q",
"Alameh MG",
"Dwivedi G",
"Davis B",
"Melamed J",
"Luo Z",
"Xu J",
"Figueroa-Espada CG",
"Xue L",
"Zeng Y",
"Han X",
"Kim D",
"Chen Q",
"Yamagata H",
"Geisler HC",
"El-Mayta R",
"Yoon IC",
"Weissman D",
"Mitchell MJ"
] | Shi Q | Mitchell MJ | [
"Prodrugs",
"Animals",
"Nanoparticles",
"Immunotherapy",
"Mice",
"RNA, Messenger",
"Lipids",
"Interleukin-12",
"Cell Line, Tumor",
"Humans",
"Indoleamine-Pyrrole 2,3,-Dioxygenase",
"Mice, Inbred C57BL",
"Colonic Neoplasms",
"T-Lymphocytes",
"Female",
"Liposomes"
] | [
"Journal Article"
] | 21 | 3 | 430-442 | null | 1748-3387 | eng | https://pubmed.ncbi.nlm.nih.gov/41851499/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41846968 | 10.64898/2026.03.03.709308 | Evaluation of an H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccine in lactating dairy cows | Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 virus has recently emerged in dairy cattle in the United States. The virus replicates primarily in the mammary gland of infected cattle, leading to dramatic reductions in milk production. It is thought that the virus transmits from animal to animal through vi... | bioRxiv | bioRxiv : the preprint server for biology | 2026 Mar 4 | 2,026 | [
"Santos JJS",
"Souza CK",
"Zanella GC",
"Goulart DB",
"Arruda B",
"Boggiatto P",
"Palmer MV",
"Snyder CA",
"Kristula MA",
"Dickens C",
"Webb TL",
"Atkinson RK",
"Dadonaite B",
"Dwivedi G",
"Alameh MG",
"Bloom JD",
"Weissman D",
"Althouse GC",
"Baker AL",
"Hensley SE"
] | Santos JJS | Hensley SE | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12991112; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41846968/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41844984 | 10.1038/s41563-026-02512-x | Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination | Modulating metabolism in immune cells is an effective approach to induce desired immune responses. Here we develop a lipid nanoparticle (LNP) capable of metabolic reprogramming of dendritic cells for mRNA vaccine applications. Using imidoester-based conjugation chemistry, we design a crosslinked ionizable lipid, C12-2a... | Nat Mater | Nature materials | 2026 Mar 17 | 2,026 | [
"Kim D",
"Gong N",
"Alameh MG",
"Han EL",
"Wang H",
"Wang J",
"Feng E",
"Yoon IC",
"Murray AM",
"Shi Q",
"Moon SJ",
"Mrksich K",
"Weissman D",
"Mitchell MJ"
] | Kim D | Mitchell MJ | [] | [
"Journal Article"
] | null | null | null | null | 1476-1122 | eng | https://pubmed.ncbi.nlm.nih.gov/41844984/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41823664 | 10.1080/22221751.2026.2645860 | Efficacy and immunological correlates of an mRNA-LNP vaccine for protection against an emerging rickettsial pathogen | A rickettsial pathogen, Ehrlichia chaffeensis, causes an emerging tick-borne disease called human monocytic ehrlichiosis (HME). E. chaffeensis in ticks expresses a porin OMP-1B, the immunodominant major outer membrane protein, which is required for nutrient uptake across the outer membrane of bacteria. We developed an ... | Emerg Microbes Infect | Emerging microbes & infections | 2026 Dec | 2,026 | [
"Lin M",
"Denton S",
"Duan N",
"Iqbal N",
"Boyaka PN",
"Dwivedi G",
"Alameh MG",
"Weissman D",
"Rikihisa Y"
] | Lin M | Rikihisa Y | [
"Animals",
"Mice",
"Antibodies, Bacterial",
"Female",
"Bacterial Outer Membrane Proteins",
"Immunoglobulin G",
"RNA, Messenger",
"Porins",
"Bacterial Vaccines",
"Nanoparticles",
"CD4-Positive T-Lymphocytes",
"CD8-Positive T-Lymphocytes",
"Interferon-gamma",
"Antibodies, Neutralizing",
"H... | [
"Journal Article"
] | 15 | 1 | 2645860 | pmc-id: PMC13159599; | 2222-1751 | eng | https://pubmed.ncbi.nlm.nih.gov/41823664/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41686204 | 10.1158/2326-6066.CIR-25-0663 | Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-cell Engineering against Pancreatic Tumors | Fibroblast activation protein (FAP), which is highly expressed on cancer-associated fibroblasts (CAF), is a promising therapeutic target to achieve normalization of the tumor microenvironment. We previously established an ex vivo retroviral-transduced FAP-specific chimeric antigen receptor (FAP-CAR) T-cell approach to ... | Cancer Immunol Res | Cancer immunology research | 2026 Apr 2 | 2,026 | [
"Bajbouj K",
"Xiao Z",
"Todd L",
"Huang L",
"Papp TE",
"Halilovic F",
"Ramani J",
"Bao Y",
"Butcher M",
"Bot A",
"Aghajanian H",
"June CH",
"Weissman D",
"Parhiz H",
"Albelda SM",
"Puré E"
] | Bajbouj K | Puré E | [
"Animals",
"Fibroblast Activation Protein Alpha",
"Nanoparticles",
"Humans",
"Pancreatic Neoplasms",
"Endopeptidases",
"RNA, Messenger",
"T-Lymphocytes",
"Receptors, Chimeric Antigen",
"Mice",
"Immunotherapy, Adoptive",
"Gelatinases",
"Membrane Proteins",
"Serine Endopeptidases",
"Cell L... | [
"Journal Article"
] | 14 | 4 | 559-570 | null | 2326-6066 | eng | https://pubmed.ncbi.nlm.nih.gov/41686204/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41610463 | 10.1016/j.vaccine.2026.128271 | Neonatal mice immune response to COVID-19 mRNA vaccine | A vaccine based on an mRNA platform was first licensed for human use during the COVID-19 pandemic. However, data on the immunogenicity of SARS-CoV-2 mRNA vaccines in neonates is insufficient and the vaccines were only authorized for those over six months of age. Here, we compared the antibody responses induced by both ... | Vaccine | Vaccine | 2026 Mar 7 | 2,026 | [
"Lotspeich-Cole L",
"Jha MK",
"Parvathaneni S",
"Lee RC",
"Weissman D",
"Major M",
"Akkoyunlu M"
] | Lotspeich-Cole L | Akkoyunlu M | [
"Animals",
"COVID-19 Vaccines",
"Mice",
"Antibodies, Viral",
"Spike Glycoprotein, Coronavirus",
"Animals, Newborn",
"COVID-19",
"Vaccines, Synthetic",
"SARS-CoV-2",
"Immunoglobulin G",
"Female",
"mRNA Vaccines",
"Adjuvants, Immunologic",
"RNA, Messenger",
"Angiotensin-Converting Enzyme 2... | [
"Journal Article"
] | 75 | null | 128271 | null | 0264-410X | eng | https://pubmed.ncbi.nlm.nih.gov/41610463/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41603124 | 10.1002/adma.202514370 | High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering | Interest continues to grow in the use of mRNA vaccines and therapeutics. While effective for immunization against infectious diseases, lipid nanoparticle (LNP) formulations used for other mRNA delivery applications suffer from off-target accumulation, poor immune transfection, and reactogenicity, limiting their applica... | Adv Mater | Advanced materials (Deerfield Beach, Fla.) | 2026 Mar | 2,026 | [
"Hamilton AG",
"Thatte AS",
"Xu J",
"Luo Z",
"Safford HC",
"Swingle KL",
"Muscat-Rivera J",
"Kegel M",
"Han X",
"Joseph RA",
"Murray AM",
"Geisler HC",
"Whitaker RC",
"Xue L",
"Spektor R",
"Melamed JR",
"Weissman D",
"Mitchell MJ"
] | Hamilton AG | Mitchell MJ | [
"Animals",
"Nanoparticles",
"RNA, Messenger",
"Lipids",
"Mice",
"High-Throughput Screening Assays",
"Cell Line, Tumor",
"Transfection",
"Liver",
"Female",
"Liposomes"
] | [
"Journal Article"
] | 38 | 13 | e14370 | pmc-id: PMC12957869; | 0935-9648 | eng | https://pubmed.ncbi.nlm.nih.gov/41603124/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41579705 | 10.1016/j.biopha.2026.119037 | Preclinical evaluation of DENV1 mRNA vaccines in mice: Toward improved neutralizing antibody and T cell responses | Dengue virus (DENV) infection represents a significant public health concern in tropical and subtropical areas, with increasing cases in parts of Europe. Currently, licensed vaccines, Dengvaxia® and Qdenga®, rely on live-attenuated platforms but show limited efficacy due to imbalanced immune responses and risks associa... | Biomed Pharmacother | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2026 Feb | 2,026 | [
"Khawsang C",
"Prompetchara E",
"Saithong S",
"Tharakhet K",
"Kaewpang P",
"Yostrerat N",
"Wangsoontorn P",
"Pitakpolrat P",
"Buranapraditkun S",
"Puttikhunt C",
"Lam K",
"Heyes J",
"Ketloy C",
"Weissman D",
"Ruxrungtham K"
] | Khawsang C | Ruxrungtham K | [
"Animals",
"Antibodies, Neutralizing",
"Dengue Virus",
"T-Lymphocytes",
"Mice, Inbred BALB C",
"Dengue Vaccines",
"Mice",
"Antibodies, Viral",
"Dengue",
"Female",
"RNA, Messenger",
"mRNA Vaccines",
"Viral Envelope Proteins"
] | [
"Journal Article"
] | 195 | null | 119037 | null | 0753-3322 | eng | https://pubmed.ncbi.nlm.nih.gov/41579705/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41556437 | 10.1002/advs.202515480 | Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity | DNA-lipid nanoparticles (DNA-LNPs) loaded with inhibitors of the cGAS-STING pathway enable safe and effective delivery of DNA in vivo. Herein, we report the first instances of extrahepatic DNA-LNP targeting. DNA-LNPs conjugated to antibodies against PECAM-1 or VCAM-1 target the endothelium of the lungs and brain/spleen... | Adv Sci (Weinh) | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | 2026 Mar | 2,026 | [
"Marzolini N",
"Brysgel TV",
"Rahman RJ",
"Essien EO",
"Nwe SY",
"Wu J",
"Majumder A",
"Patel MN",
"Tiwari S",
"Espy CL",
"Dong F",
"Santos-De León SA",
"Shah A",
"Shuvaev VV",
"Hood ED",
"Chase LS",
"Weissman D",
"Katzen JB",
"Frank DB",
"Bennett ML",
"Marcos-Contreras OA",
... | Marzolini N | Brenner JS | [
"Animals",
"Endothelial Cells",
"DNA",
"Nanoparticles",
"Mice",
"Lipids",
"Vascular Cell Adhesion Molecule-1",
"Lung",
"Platelet Endothelial Cell Adhesion Molecule-1",
"Liver",
"Liposomes"
] | [
"Journal Article"
] | 13 | 14 | e15480 | pmc-id: PMC12970279; | 2198-3844 | eng | https://pubmed.ncbi.nlm.nih.gov/41556437/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41453893 | 10.1038/s41541-025-01317-4 | An influenza HA mRNA-LNP vaccine induces potent responses in newborn nonhuman primates that enhance protection from challenge | Influenza virus infection poses a significant health risk to newborns, with this population experiencing higher hospitalization and mortality rates compared to older children. The heightened vulnerability of this age group results from a combination of an altered immune system and lack of a licensed vaccine for childre... | NPJ Vaccines | NPJ vaccines | 2025 Dec 26 | 2,025 | [
"Page CL",
"Holbrook BC",
"Crofts KF",
"Alameh MG",
"Davis B",
"Caudell D",
"Weissman D",
"Alexander-Miller MA"
] | Page CL | Alexander-Miller MA | [] | [
"Journal Article"
] | 11 | 1 | 2 | pmc-id: PMC12764487; | 2059-0105 | eng | https://pubmed.ncbi.nlm.nih.gov/41453893/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41453244 | 10.1016/j.vaccine.2025.128099 | mRNA vaccines targeting Leptospira immunoglobulin-like proteins confer partial protection in a hamster model of leptospirosis | Leptospirosis is a neglected tropical disease with significant global health and economic impacts, particularly in resource-limited regions. This study reports the development of the first mRNA-based vaccines for leptospirosis, targeting the C-terminal region of LigA (LigAc) and the N-terminal region of LigB (LigBn) of... | Vaccine | Vaccine | 2026 Feb 15 | 2,026 | [
"Techawiwattanaboon T",
"Leekitcharoenphon R",
"Alameh MG",
"Boonkea S",
"Sangkanjanavanich N",
"Nakornpakdee Y",
"Ajimathorn Y",
"Prompetchara E",
"Ketloy C",
"Buranapraditkun S",
"Palaga T",
"Kanthawong S",
"Heyes J",
"Weissman D",
"Ruxrungtham K",
"Patarakul K"
] | Techawiwattanaboon T | Patarakul K | [
"Animals",
"Leptospirosis",
"Mice",
"Disease Models, Animal",
"Antibodies, Bacterial",
"Cricetinae",
"Bacterial Vaccines",
"Antigens, Bacterial",
"Humans",
"Vaccines, Synthetic",
"Immunoglobulin G",
"HEK293 Cells",
"Female",
"Bacterial Proteins",
"Leptospira",
"Mesocricetus",
"Leptos... | [
"Journal Article"
] | 73 | null | 128099 | null | 0264-410X | eng | https://pubmed.ncbi.nlm.nih.gov/41453244/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41427412 | 10.64898/2025.12.08.693081 | An integrated workflow for structural virology with a 100 keV electron microscope | Cryo-EM has revolutionized structural biology, especially for flexible and heterogeneous samples, although access to high end microscopes that enable these studies remains a bottleneck. While 300 keV microscopes have been the go-to for high-resolution structural determination, they are expensive and restricted to insti... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Dec 10 | 2,025 | [
"Pathirage R",
"Dutta M",
"Parsons RJ",
"Lella M",
"Atwood E",
"Zhang QE",
"May A",
"Johnson A",
"Huang X",
"Flemming J",
"Kumar U",
"Marayati BF",
"Spurrier MA",
"Liu C",
"Zhuo J",
"Song K",
"Adhikari RD",
"Sammour S",
"Ilevbare V",
"Abram C",
"Diaz M",
"Guzman A",
"Rai ... | Pathirage R | Acharya P | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12713605; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41427412/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41317703 | 10.1016/j.biomaterials.2025.123869 | Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries | The use of macrophage cell therapies is limited by their tendency to change phenotype in response to external cues in situ. Here we demonstrate that an optimized lipid nanoparticle (LNP) formulation effectively delivers IL4 mRNA to human and murine primary macrophages, resulting in rapid transfection, IL-4 secretion, a... | Biomaterials | Biomaterials | 2026 May | 2,026 | [
"O'Brien EM",
"Tylek T",
"Geisler HC",
"Mukalel AJ",
"Whitaker RC",
"Sung S",
"Binder-Markey BI",
"Weissman D",
"Mitchell MJ",
"Spiller KL"
] | O'Brien EM | Spiller KL | [
"Macrophages",
"Animals",
"Interleukin-4",
"Nanoparticles",
"Humans",
"RNA, Messenger",
"Inflammation",
"Mice",
"Lipids",
"Phenotype",
"Mice, Inbred C57BL",
"Cell- and Tissue-Based Therapy",
"Liposomes"
] | [
"Journal Article"
] | 328 | null | 123869 | pmc-id: PMC13112448;manuscript-id: NIHMS2163147; | 0142-9612 | eng | https://pubmed.ncbi.nlm.nih.gov/41317703/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41280059 | 10.1101/2025.10.17.683125 | Anionic lipids modulate mRNA-lipid nanoparticle immunogenicity and confer protection in a mouse model of multiple sclerosis | The modularity of mRNA-lipid nanoparticle (mRNA-LNP) platforms has enabled their rapid adaptation from infectious disease vaccines to emerging applications in immune-mediated disorders. However, extending mRNA-LNPs to autoimmune and inflammatory diseases requires precise control over immune cell targeting and immunogen... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Oct 17 | 2,025 | [
"Melamed JR",
"Muscat-Rivera J",
"Kegel M",
"Chaboub LS",
"Perez-Tremble R",
"Bhalla NS",
"Ni H",
"Sun H",
"Weissman D"
] | Melamed JR | Weissman D | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12632872; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41280059/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41278942 | 10.1101/2025.10.06.680687 | Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design | A major obstacle confronting HIV-1 vaccine and cure research is the lack of an outbred animal model for rapid and consistent induction of broadly neutralizing antibodies (bNAbs). We designed an epitope-focused simian-human immunodeficiency virus (SHIV.5MUT) that elicited broad and potent V3-glycan-targeted antibodies w... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Oct 6 | 2,025 | [
"Skelly AN",
"Gristick HB",
"Li H",
"Gavor E",
"Connell AJ",
"Kreider EF",
"Marchitto L",
"Hogarty MP",
"Newby ML",
"Allen JD",
"Liu W",
"West AP Jr",
"Ayyanathan K",
"Campion MS",
"Winters K",
"Gordon CG",
"Osbaldeston RA",
"Akeley MJ",
"Li Y",
"Singh A",
"Cruickshank K",
... | Skelly AN | Shaw GM | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12632488; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41278942/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41278637 | 10.1101/2025.10.29.685358 | In vivo reprogramming of cytotoxic effector CD8 (+) T cells via fractalkine-conjugated mRNA-LNP | Selective in vivo reprogramming of cytotoxic effector CD8 + T (T eff ) cells holds tremendous promise as a therapeutic tool but has not yet been accomplished. Here, we demonstrate that fractalkine-conjugated mRNA lipid nanoparticles (mRNA-LNP) can specifically target and deliver mRNA to CX3CR1 + T eff cells in vitro an... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Oct 30 | 2,025 | [
"Corrigan AR",
"Ngiow SF",
"Statzu M",
"Pampena MB",
"Nordin JML",
"Albertus A",
"Carro SD",
"Harper J",
"Stammen RL",
"Wood J",
"Hamilton JT",
"Ni H",
"Su J",
"Ramalingam R",
"Wu VH",
"Paiardini M",
"Weissman D",
"Wherry EJ",
"Kreider EF",
"Betts MR"
] | Corrigan AR | Betts MR | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12636507; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41278637/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41256582 | 10.1101/2025.09.26.678832 | Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy | Oral squamous cell carcinoma (OSCC) represents 90% of all head and neck cancers. Despite decades of research, the 5-year survival rate is 50%, and strikingly, the overall incidence rate is projected to increase by 30% in the next ten years, which will result in a sharp increase in mortality. Two fundamental aspects of ... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Oct 6 | 2,025 | [
"Padilla MS",
"Li JJ",
"Zhang Q",
"Patwari K",
"Shi S",
"Yamagata HM",
"Joseph RA",
"Hymms BN",
"Teerdhala SV",
"Alameh MG",
"Weissman D",
"Le AD",
"Mitchell MJ"
] | Padilla MS | Mitchell MJ | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12621659; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/41256582/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41225668 | 10.1093/carcin/bgaf082 | SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer | Tyrosine kinase (TK) inhibitors improve clinical outcomes in non-small cell lung cancer (NSCLC) with targetable mutations. However, such NSCLC cases account for only about 50% in the western populations. Inhibition of the splicing factor SRSF3 has been reported to be tumor-suppressive in other cancer cell types. This s... | Carcinogenesis | Carcinogenesis | 2025 Nov 21 | 2,025 | [
"Nakamichi S",
"von Muhlinen N",
"Yamada L",
"Melamed JR",
"Papp TE",
"Parhiz H",
"Weissman D",
"Horikawa I",
"Harris CC"
] | Nakamichi S | Harris CC | [
"Humans",
"Carcinoma, Non-Small-Cell Lung",
"Serine-Arginine Splicing Factors",
"Cellular Senescence",
"Lung Neoplasms",
"Cell Proliferation",
"Apoptosis",
"Tumor Suppressor Protein p53",
"Cell Line, Tumor",
"Gene Expression Regulation, Neoplastic",
"RNA, Small Interfering",
"A549 Cells",
"G... | [
"Journal Article",
"Research Support, N.I.H., Intramural"
] | 46 | 4 | null | pmc-id: PMC12629605;manuscript-id: NIHMS2122621; | 0143-3334 | eng | https://pubmed.ncbi.nlm.nih.gov/41225668/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41111389 | 10.1161/CIRCULATIONAHA.125.074120 | Hypercontractility and Oxidative Stress Drive Creatine Kinase Dysfunction in Hypertrophic Cardiomyopathy | Hypertrophic cardiomyopathy (HCM) is a prevalent inherited cardiac disorder marked by left ventricular hypertrophy and hypercontractility. This excessive mechanical workload creates an energetic mismatch in which consumption exceeds production, leading to myocardial energy depletion. Although CK (creatine kinase) plays... | Circulation | Circulation | 2025 Dec 16 | 2,025 | [
"Xu A",
"Weissman D",
"Ermer KJ",
"Bertero E",
"Federspiel JM",
"Stadler F",
"Grünler E",
"Tangos M",
"Zervou S",
"Waddingham MT",
"Pearson JT",
"Reil JC",
"Scholtz S",
"Dudek J",
"Kohlhaas M",
"Nickel AG",
"Carrier L",
"Eschenhagen T",
"Michels M",
"Dos Remedios C",
"Lal S",... | Xu A | Sequeira V | [
"Animals",
"Oxidative Stress",
"Humans",
"Cardiomyopathy, Hypertrophic",
"Male",
"Myocytes, Cardiac",
"Mice",
"Female",
"Middle Aged",
"Creatine Kinase",
"Mitochondria, Heart",
"Myocardial Contraction",
"Adult",
"Mice, Knockout",
"Mice, Inbred C57BL",
"Hydrogen Peroxide",
"Carrier Pr... | [
"Journal Article"
] | 152 | 24 | 1705-1727 | pmc-id: PMC13227915;manuscript-id: NIHMS2115955;embargo-date: 2026/10/20; | 0009-7322 | eng | https://pubmed.ncbi.nlm.nih.gov/41111389/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
41028170 | 10.1038/s41573-025-01291-5 | In vivo chimeric antigen receptor (CAR)-T cell therapy | Chimeric antigen receptor (CAR)-T cell therapy has transformed the outcomes of patients with haematological malignancies, yet its use is limited by labour-intensive manufacturing, constrained production capacity and variable clinical performance. In vivo CAR-T cell engineering, in which CAR-T cells are generated direct... | Nat Rev Drug Discov | Nature reviews. Drug discovery | 2026 Feb | 2,026 | [
"Bot A",
"Scharenberg A",
"Friedman K",
"Guey L",
"Hofmeister R",
"Andorko JI",
"Klichinsky M",
"Neumann F",
"Shah JV",
"Swayer AJ",
"Trudeau K",
"Weissman D",
"Stephan MT",
"Buchholz CJ",
"June CH"
] | Bot A | June CH | [
"Humans",
"Receptors, Chimeric Antigen",
"Animals",
"Immunotherapy, Adoptive",
"T-Lymphocytes",
"Nanoparticles",
"Genetic Vectors",
"Hematologic Neoplasms"
] | [
"Journal Article",
"Review"
] | 25 | 2 | 116-137 | null | 1474-1776 | eng | https://pubmed.ncbi.nlm.nih.gov/41028170/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40985871 | 10.1172/JCI194080 | Allergen-specific mRNA-lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice | Allergic diseases have reached epidemic proportions globally, calling attention to the need for better treatment and preventive approaches. Herein, we developed allergen-encoding messenger RNA (mRNA)-lipid nanoparticle (LNP) strategies for both therapy and prevention of allergic responses. Immunization with allergen-en... | J Clin Invest | The Journal of clinical investigation | 2025 Nov 3 | 2,025 | [
"Rochman Y",
"Kotliar M",
"Klingler AM",
"Rochman M",
"Alameh MG",
"Melamed JR",
"Osswald GA",
"Caldwell JM",
"Felton JM",
"Mack LE",
"Hargis J",
"Lewkowich IP",
"Barski A",
"Weissman D",
"Rothenberg ME"
] | Rochman Y | Rothenberg ME | [
"Animals",
"Mice",
"Nanoparticles",
"Asthma",
"RNA, Messenger",
"Allergens",
"Antigens, Dermatophagoides",
"Disease Models, Animal",
"Female",
"Humans",
"Lipids",
"Arthropod Proteins",
"Mice, Inbred BALB C",
"Pyroglyphidae",
"SARS-CoV-2",
"Ovalbumin",
"COVID-19 Vaccines",
"Hypersen... | [
"Journal Article",
"Research Support, N.I.H., Extramural",
"Research Support, Non-U.S. Gov't"
] | 135 | 21 | null | pmc-id: PMC12578384; | 0021-9738 | eng | https://pubmed.ncbi.nlm.nih.gov/40985871/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40969676 | 10.1016/j.omtm.2025.101566 | Harnessing mRNA-lipid nanoparticles as innovative therapies for autoimmune diseases | Autoimmune diseases are chronic conditions where the immune system mistakenly attacks healthy tissues, leading to potentially debilitating symptoms that require lifelong management. There are no cures for autoimmune diseases, and new treatments are urgently needed to improve patient outcomes. This review delves into th... | Mol Ther Methods Clin Dev | Molecular therapy. Methods & clinical development | 2025 Sep 11 | 2,025 | [
"Razavi R",
"Kegel M",
"Muscat-Rivera J",
"Weissman D",
"Melamed JR"
] | Razavi R | Melamed JR | [] | [
"Journal Article",
"Review"
] | 33 | 3 | 101566 | pmc-id: PMC12441705; | 2329-0501 | eng | https://pubmed.ncbi.nlm.nih.gov/40969676/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40910688 | 10.1128/jvi.01355-25 | Hepatitis C virus modified (S)E2(F442NYT)-mRNA-LNP candidate vaccine promotes helper CXCR5(+)T cells | T cells play an important role in initiating antibody responses by instructive signals of cell-cell contacts and secretion of soluble cytokines as mediators. We investigated the role of the modified soluble E2 (sE2F442NYT) antigen from hepatitis C virus (HCV) on healthy human peripheral blood mononuclear cell (PBMC)-de... | J Virol | Journal of virology | 2025 Oct 23 | 2,025 | [
"Haga Y",
"Babu E P",
"Swiderska-Syn M",
"Reagan EK",
"Weissman D",
"Ray R"
] | Haga Y | Ray R | [
"Animals",
"Humans",
"Mice",
"Hepacivirus",
"Th17 Cells",
"Receptors, CXCR5",
"Viral Hepatitis Vaccines",
"RNA, Messenger",
"Nanoparticles",
"Female",
"Interleukin-17",
"Hepatitis C",
"Leukocytes, Mononuclear",
"T-Lymphocytes, Helper-Inducer",
"Liposomes",
"Viral Envelope Proteins"
] | [
"Journal Article",
"Research Support, N.I.H., Extramural"
] | 99 | 10 | e0135525 | pmc-id: PMC12548457; | 0022-538X | eng | https://pubmed.ncbi.nlm.nih.gov/40910688/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40895389 | 10.1016/j.lansea.2025.100650 | Immunogenicity and safety of 'Comvigen', a bivalent SARS-CoV-2 vaccine, in comparison to Comirnaty bivalent vaccine in Thailand: a phase 2, non-inferiority randomised trial | Strengthening mRNA vaccine development in LMICs is essential for enhancing global pandemic preparedness. This study evaluated the safety and immunogenicity of Comvigen, a bivalent SARS-CoV-2 vaccine, in comparison to the Comirnaty bivalent vaccine (Comirnaty). This phase II, randomised, open-label, non-inferiority tria... | Lancet Reg Health Southeast Asia | The Lancet regional health. Southeast Asia | 2025 Sep | 2,025 | [
"Jantarabenjakul W",
"Nantanee R",
"Puthanakit T",
"Gatechompol S",
"Avihingsanon A",
"Punrin S",
"Tantawichien T",
"Nitayaphan S",
"Thitithanyanont A",
"Buranapraditkun S",
"Jongkaewwattana A",
"Ketloy C",
"Prompetchara E",
"Lawpoolsri S",
"Wijagkanalan W",
"Alameh MG",
"Hong L",
... | Jantarabenjakul W | Ruxrungtham K | [] | [
"Journal Article"
] | 40 | null | 100650 | pmc-id: PMC12390948; | 2772-3682 | eng | https://pubmed.ncbi.nlm.nih.gov/40895389/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40872809 | 10.3390/v17081095 | Homologous and Heterologous Vaccination Regimens with mRNA and rVSV Platforms Induce Potent Immune Responses Against SFTSV Glycoprotein | Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic bunyavirus with a high case-fatality ratio for which there is no approved vaccine. Studies have assessed different vaccine technologies. However, few studies have yet assessed the immunogenicity of heterologous prime-boost regimens. Here, ... | Viruses | Viruses | 2025 Aug 8 | 2,025 | [
"Manzoni TB",
"Westover JB",
"Lundgreen KA",
"Hicks PD",
"Petch RJ",
"Ort JT",
"Weissman D",
"Fan SHY",
"Hensley SE",
"Pardi N",
"Gowen BB",
"Bates P"
] | Manzoni TB | Bates P | [
"Animals",
"Mice",
"Viral Vaccines",
"Antibodies, Viral",
"RNA, Messenger",
"Phlebovirus",
"Vaccination",
"Female",
"Glycoproteins",
"Vaccines, Synthetic",
"Severe Fever with Thrombocytopenia Syndrome",
"Immunity, Cellular",
"Mice, Inbred BALB C",
"Antibodies, Neutralizing",
"Immunoglobu... | [
"Journal Article"
] | 17 | 8 | null | pmc-id: PMC12390526; | 1999-4915 | eng | https://pubmed.ncbi.nlm.nih.gov/40872809/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40832631 | 10.1016/j.omtn.2025.102645 | mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice | Plasmodium vivax poses significant challenges to malaria control due to its relapsing nature. This study explores the immunogenicity and efficacy of nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccines targeting the P. vivax circumsporozoite protein (PvCSP). Two mRNA constructs encoding PvCSP were designed and te... | Mol Ther Nucleic Acids | Molecular therapy. Nucleic acids | 2025 Sep 9 | 2,025 | [
"Limsalakpetch A",
"Kum-Arb U",
"Yongvanitchit K",
"Im-Erbsin R",
"Ubalee R",
"Waters N",
"Vesely BA",
"Muramatsu H",
"Weissman D",
"Tam YK",
"Yoshida S",
"Adams J",
"Yadava A",
"Pardi N",
"Pichyangkul S"
] | Limsalakpetch A | Pichyangkul S | [] | [
"Journal Article"
] | 36 | 3 | 102645 | pmc-id: PMC12359152; | 2162-2531 | eng | https://pubmed.ncbi.nlm.nih.gov/40832631/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40745065 | 10.1038/s41551-025-01486-6 | Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity | null | Nat Biomed Eng | Nature biomedical engineering | 2025 Dec | 2,025 | [
"Gong N",
"Kim D",
"Alameh MG",
"El-Mayta R",
"Han EL",
"Dwivedi G",
"Palanki R",
"Shi Q",
"Han X",
"Xue L",
"Xu J",
"Meng Z",
"Luo T",
"Figueroa-Espada CG",
"Weissman D",
"Li J",
"Mitchell MJ"
] | Gong N | Mitchell MJ | [] | [
"Published Erratum"
] | 9 | 12 | 2215 | null | 2157-846X | eng | https://pubmed.ncbi.nlm.nih.gov/40745065/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40738519 | 10.1016/j.jacbts.2025.101333 | ATP-Citrate Lyase in Heart Failure: A Redox Node in NAD(+)/NADH Homeostasis | null | JACC Basic Transl Sci | JACC. Basic to translational science | 2025 Jul | 2,025 | [
"Weissman D",
"Maack C"
] | Weissman D | Maack C | [] | [
"Editorial"
] | 10 | 7 | 101333 | pmc-id: PMC12434228; | 2452-302X | eng | https://pubmed.ncbi.nlm.nih.gov/40738519/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40681859 | 10.1038/s41551-025-01422-8 | Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity | The immunogenicity of lipid nanoparticles (LNPs) used for the delivery of nucleoside-modified messenger RNA limits the levels and durability of expression of the encoded protein. Here, by leveraging the Mannich reaction for ionizable lipid synthesis, and via the in vitro and in vivo screening of six combinatorial libra... | Nat Biomed Eng | Nature biomedical engineering | 2025 Dec | 2,025 | [
"Gong N",
"Kim D",
"Alameh MG",
"El-Mayta R",
"Han EL",
"Dwivedi G",
"Palanki R",
"Shi Q",
"Han X",
"Xue L",
"Xu J",
"Meng Z",
"Luo T",
"Figueroa-Espada CG",
"Weissman D",
"Li J",
"Mitchell MJ"
] | Gong N | Mitchell MJ | [
"Animals",
"Lipids",
"Mice",
"RNA, Messenger",
"Humans",
"Nanoparticles",
"Antioxidants",
"SARS-CoV-2",
"Spike Glycoprotein, Coronavirus",
"COVID-19",
"Female",
"Reactive Oxygen Species",
"Gene Transfer Techniques",
"Combinatorial Chemistry Techniques",
"Gene Editing",
"Liposomes"
] | [
"Journal Article"
] | 9 | 12 | 2181-2195 | null | 2157-846X | eng | https://pubmed.ncbi.nlm.nih.gov/40681859/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40672218 | 10.1101/2025.07.09.663747 | Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity | DNA-lipid nanoparticles (DNA-LNPs) loaded with inhibitors of the cGAS-STING pathway enable safe and effective delivery of DNA in vivo . Herein, we report the first instances of extrahepatic DNA-LNP targeting. DNA-LNPs conjugated to antibodies against PECAM-1 or VCAM-1 target the endothelium of the lungs and brain/splee... | bioRxiv | bioRxiv : the preprint server for biology | 2025 Oct 23 | 2,025 | [
"Marzolini N",
"Brysgel TV",
"Rahman RJ",
"Essien EO",
"Nwe SY",
"Wu J",
"Majumder A",
"Patel MN",
"Tiwari S",
"Espy CL",
"Dong F",
"Shah A",
"Shuvaev VV",
"Hood ED",
"Chase LS",
"Weissman D",
"Katzen JB",
"Frank DB",
"Bennett ML",
"Marcos-Contreras OA",
"Myerson JW",
"Muzy... | Marzolini N | Brenner JS | [] | [
"Journal Article",
"Preprint"
] | null | null | null | pmc-id: PMC12265523; | 2692-8205 | eng | https://pubmed.ncbi.nlm.nih.gov/40672218/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
40670370 | 10.1038/s41541-025-01213-x | IL-12 mRNA-LNP promotes dermal resident memory CD4(+) T cell development | Dermal resident memory CD4+ T cells (dTrm) provide protection against vector-borne infections. However, the factors that promote their development remain unclear. We tested if an mRNA vaccine, encoding a protective leishmanial antigen, induced dTrm cells. The mRNA vaccine induced robust systemic T-cell responses, but f... | NPJ Vaccines | NPJ vaccines | 2025 Jul 16 | 2,025 | [
"Zabala-Peñafiel A",
"Gonzalez-Lombana C",
"Alameh MG",
"Sacramento LA",
"Mou Z",
"Phan AT",
"Aunins EA",
"Tam YK",
"Uzonna JE",
"Weissman D",
"Hunter CA",
"Scott P"
] | Zabala-Peñafiel A | Scott P | [] | [
"Journal Article"
] | 10 | 1 | 154 | pmc-id: PMC12267433; | 2059-0105 | eng | https://pubmed.ncbi.nlm.nih.gov/40670370/ | BaQcQa62qrhFCBhYV | vZLiaTlv24nA5laiM |
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