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Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. BACKGROUND AND PURPOSE: H2 O2 is widely understood to regulate intracellular signalling. In airway epithelia, H2 O2 stimulates anion secretion primarily by activating an autocrine P... | Are adenylyl cyclases always transmembrane proteins? | 56e5aeec0c19e5451d000002_002 | no |
A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. BACKGROUND: Venlafaxine blocks both serotonin and norepinephrine transporters (SERT and NET), with higher affinity for SERT. Serotonergic effects occur with lower doses, whereas both sero... | Can venlafaxine block NET and SERT? | 56cf32e23975bb303a000006_008 | yes |
Dabigatran-related intracerebral hemorrhage resulting in hematoma expansion. Warfarin-related intracerebral hemorrhage carries a particularly high risk of neurologic deterioration and death because of a high rate of hematoma expansion of about 50%. Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaba... | Are there any specific antidotes for dabigatran? | 532f08dcd6d3ac6a3400002a_010 | no |
The commensal microbiota exacerbate infectious colitis in stressor-exposed mice. Exposure to a prolonged restraint stressor disrupts the colonic microbiota community composition, and is associated with an elevated inflammatory response to colonic pathogen challenge. Since the stability of the microbiota has been implic... | Is Citrobacter rodentium pathogenic? | 5aa4faaed6d6b54f7900000b_001 | yes |
BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. PURPOSE: CXCR4 has been identified as a prognostic marker for acute myeloid leukemia (AML) and other malignancies. We describe the development and characterization of a ful... | Is protein CXCR4 used as a prognostic marker of cancer? | 56e68967edfc094c1f000002_009 | yes |
[Clinical study of Pentraxin 3 in diagnosing the severity and cardiovascular function of the children with sepsis]. OBJECTIVE: To study the value of Pentraxin 3 (PTX3) in diagnosing the severity and cardiovascular function of the critically ill children. Method A total of 178 patients who were older than 28 days, with ... | Can Pentraxin 3 predict outcomes of sepsis? | 5890eb22621ea6ff7e000006_007 | yes |
Is autosomal recessive deafness associated with oculocutaneous albinism a "coincidence syndrome"? Hearing impairment is frequently found associated with pigmentary disorders in many syndromes. However, total oculocutaneous albinism (OCA) associated with deafness has been described only once, by Ziprkowski and Adam (Arc... | Does oculocutaneous albinism show an autosomal recessive inheritance? | 58cbb55402b8c60953000033_012 | yes |
Valproic acid triggers erythro/megakaryocyte lineage decision through induction of GFI1B and MLLT3 expression. Histone deacetylase inhibitors represent a family of targeted anticancer compounds that are widely used against hematological malignancies. So far little is known about their effects on normal myelopoiesis. Th... | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | 553bd2f0f321868558000008_013 | yes |
A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis. Titin is the largest protein known, and is essential for organising muscle sarcomeres. It has many domains with a variety of functions, and stretches from the Z-line to the M-line in the muscle sarcomere. ... | Is Titin the largest single protein molecule found in Nature? | 55030a6ce9bde6963400000f_009 | yes |
Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. Mammalian DNA replication starts at distinct chromosomal sites in a tissue-specific pattern coordinated with transcription, but previous studies have not yet identified a chromatin ... | Is H4K20 methylation associated with DNA replication? | 58adbe999ef3c34033000005_005 | yes |
Exploding head syndrome is common in college students. Exploding head syndrome is characterized by the perception of loud noises during sleep-wake or wake-sleep transitions. Although episodes by themselves are relatively harmless, it is a frightening phenomenon that may result in clinical consequences. At present there... | Is there a disease or condition called Exploding Head Syndrome? | 5a8ee9d1fcd1d6a10c000027_011 | yes |
Successful treatment of refractory aortitis in antineutrophil cytoplasmic antibody-associated vasculitis using tocilizumab. A 47-year-old Japanese woman developed antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) complicated by a rare combination of aortitis and hypertrophic pachymeningitis. Despit... | Is Tocilizumab effective for Giant-Cell Arteritis? | 5a733d2a2dc08e987e000015_001 | yes |
Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation. Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous... | Are microRNA (miR) regulated through DNA methylation of their promoters? | 53636e727d100faa0900000d_008 | yes |
An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae. Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a prerequisite for their alignment on the spindle apparatus and segregation in mitosis. Budding yeast cohesin first associates with chromosomes in G1.... | Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | 553cae13f32186855800000e_003 | yes |
Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells. Sodium alginate hydrogel, stabilized with gelatin, is a suitable, biologically inert matrix that can be used for encapsulating and 3D bioprinting of bone-related SaOS-2 cells. However... | Can bioprinting use human cells? | 571394141174fb175500000b_006 | yes |
Cardiorenal syndrome in chronic kidney disease. PURPOSE OF REVIEW: The purpose of this study is to review current perspectives regarding the pathogenesis of cardiorenal syndrome (CRS) in chronic kidney disease (CKD), and current treatment guidelines for this condition. RECENT FINDINGS: The pathophysiological mechanisms... | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | 570a5c27cf1c325851000023_003 | yes |
[The molecular genetic background of hereditary craniosynostoses and chondrodysplasias]. Fibroblast growth factors are structurally related proteins associated with cell growth, differentiation, migration, wound healing, angiogenesis, and oncogenesis. At the cellular level, their function is mediated by transmembrane t... | Is there an association between Muenke Syndrome and FGFR3 gene mutation? | 5895ec5e7d9090f353000015_006 | yes |
Nephrotic syndrome in diabetic kidney disease: an evaluation and update of the definition. BACKGROUND: Nephrotic syndrome is defined as urine total protein excretion greater than 3.5 g/d or total protein-creatinine ratio greater than 3.5 g/g, low serum albumin level, high serum cholesterol level, and peripheral edema. ... | Is edema a symptom of nephrotic syndrome? | 58da270d8acda34529000013_000 | yes |
Beta-trace protein and cystatin c as predictors of major bleeding in non-ST-segment elevation acute coronary syndrome. BACKGROUND: Beta-trace protein (BTP) and cystatin C (CysC) are novel biomarkers of renal function. We assessed the ability of both to predict major bleeding (MB) in patients with non-ST-segment elevati... | Is cystatin C or cystatin 3 used as a biomarker of kidney function? | 550bf315c2af5d5b7000000e_005 | yes |
Recent structural studies on Dom34/aPelota and Hbs1/aEF1α: important factors for solving general problems of ribosomal stall in translation. In the translation process, translating ribosomes usually move on an mRNA until they reach the stop codon. However, when ribosomes translate an aberrant mRNA, they stall. Then, ri... | Is the protein pelota a ribosomal rescue factor? | 5ad35933133db5eb78000001_002 | yes |
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC) highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence fo... | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | 54d63d873706e89528000006_006 | yes |
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells. Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TE... | Are piRNAs involved in gene silencing? | 56c6f6005795f9a73e000009_001 | yes |
Cutaneous melioidosis. Melioidosis is a rare tropical disease caused by infection with the bacterium Burkholderia pseudomallei. It occurs predominantly in south-east Asia, northern and central Australia and central and south America. Patients often present to the internal medicine physicians with a severe, potentially ... | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | 58caf88c02b8c60953000031_034 | yes |
[Severe urge incontinence--therapeutic concept]. Basing on our experience with 39 patients with severe urge incontinence (in one-quarter of the cases pure urge incontinence, in one-half of the cases mixed incontinence and in a further quarter of the cases neurogenic bladder disorders) a supervised programme (mictiogram... | Is Bladder training an effective method to treat urge incontinence ? | 515df98f298dcd4e51000030_012 | yes |
Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyond. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a primary electrical myocardial disease characterized by exercise- and stress-related ventricular tachycardia manifested as syncope and sudden death. The disease has a ... | Is Calcium homeostasis important in cardiac physiology and pathophysiology? | 54c26e29f693c3b16b000003_004 | yes |
Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells. High-fidelity maintenance of genomic integrity in eukaryotes is ensured by cell cycle checkpoints and DNA repair. The checkpoint kinase, Chk2, has been implicated in both of these ... | Is CHEK2 involved in cell cycle control? | 53175e25b166e2b806000007_001 | yes |
Overexpression of miR-145 increases the sensitivity of vemurafenib in drug-resistant colo205 cell line. Vemurafenib is a selective and potent small molecule inhibitor of the V600 mutant form of the BRAF protein used in the treatment of melanoma and colorectal cancer. However, vemurafenib has less effect in BRAF mutant ... | Are BRAF mutations common in melanoma? | 5512c91b6a8cde6b7200000b_008 | yes |
A novel STXBP1 mutation causes focal seizures with neonatal onset. Mutations of the syntaxin binding protein 1 (STXBP1) have been associated with severe infantile epileptic encephalopathies (Ohtahara syndrome and West syndrome), but also with moderate to severe cognitive impairment and nonsyndromic epilepsy. We have st... | Are mutations in the STXBP1 gene associated with epilepsy? | 550748a3bde8548216000001_012 | yes |
Identification and characterization of a Brucella abortus ATP-binding cassette transporter homolog to Rhizobium meliloti ExsA and its role in virulence and protection in mice. Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. The me... | Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | 5aa6800ad6d6b54f79000011_007 | no |
Neuroglobin upregulation offers neuroprotection in traumatic brain injury. OBJECTIVES: The aim of this study was to investigate rat neuroglobin (rNGB) expression level after traumatic brain injury (TBI) and further study its neuroprotective effects in TBI when it was overexpressed in adenoviral vector. METHODS: The Wis... | Does neuroglobin has neuroprotective properties in the setting of traumatic brain injury? | 56c1d846ef6e39474100002e_004 | yes |
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. F-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCF(FBW7) (a complex of SKP1, cullin-1 and FBW7), plays important roles in various physiological and pathological processes. Alt... | Is protein Fbw7 a SCF type of E3 ubiquitin ligase? | 550ae16bc2af5d5b70000009_010 | yes |
Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in Mexico. BACKGROUND: Frequent recurrent mutations in the breast and ovarian cancer susceptibility (BRCA) genes BRCA1 and BRCA2 among Hispanics, including a large rearrangement Mexican founder mutation (BRCA1 exon 9-12 deletion [ex9-12del]), suggest th... | Could BRCA gene test used for breast and ovarian cancer risk? | 58a6bce660087bc10a000029_000 | yes |
Suppression of clonogenicity by mammalian Dnmt1 mediated by the PCNA-binding domain. Overexpression of the major DNA methyltransferase Dnmt1 is cytotoxic and has been hypothesized to result in aberrant hypermethylation of genes required for cell survival. Indeed, overexpression of mouse or human Dnmt1 in murine and hum... | Could DNA (cytosine-5-)-methyltransferases serve as tumour markers? | 5162e9df298dcd4e5100004b_013 | yes |
Genome-wide characterization of mammalian promoters with distal enhancer functions. Gene expression in mammals is precisely regulated by the combination of promoters and gene-distal regulatory regions, known as enhancers. Several studies have suggested that some promoters might have enhancer functions. However, the ext... | Are there mammalian promoters with distal enhancer functions? | 5a6fabfeb750ff4455000062_000 | yes |
A case of vomiting in an anorexic achalasic patient. Wernicke's encephalopathy is a neurological disorder caused by thiamine (vitamin B1) deficiency characterized by vertigo, ataxia, and mental confusion. Wernicke's encephalopathy has a causative association with alcoholism but recently there has been an increased prev... | Can vitamin B1 deficiency cause encephalopathy? | 572211540fd6f91b68000016_007 | yes |
Omission of breakfast and risk of gastric cancer in Mexico. AIM: To investigate factors associated with gastric cancer (GC) in the Mexican population using a validated questionnaire. METHODS: We designed and validated in Spanish a Questionnaire to Find Factors Associated with Diseases of the Digestive Tract using GC as... | Is Crohn's disease (CD) linked to the consumption of refrigerated food? | 56cae40b5795f9a73e000022_001 | yes |
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties, but less is known about how they induce cell death. Here, we show that both type I (α/β) and type II (γ) IFNs induce precipitous rec... | Is RIP1 (RIP-1) part of the necrosome? | 532bfd15d6d3ac6a34000017_002 | yes |
[Treatment of amyotrophic lateral sclerosis with daily intrathecal TRH. A year's experience. Pilot study II]. This study presents the experience of one year of treatment in patients with amyotrophic lateral sclerosis, with intrathecal TRH administered daily by a subcutaneous reservoir connected to the intrathecal lumba... | Is there any data to suggest that TRH (thyrotropin releasing hormone) administration can improve symptom severity of amyotrophic lateral sclerosis patients? | 54d76ac63706e89528000016_003 | yes |
The role of chemokine receptor CXCR4 in the biologic behavior of human soft tissue sarcoma. The molecular basis of sarcoma remains poorly understood. However, recent studies have begun to uncover some of the molecular pathways involved in sarcomagenesis. The chemokine receptor CXCR4 has been implicated in sarcoma devel... | Is protein CXCR4 used as a prognostic marker of cancer? | 56e68967edfc094c1f000002_005 | yes |
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A residues to transcript regions 100-200 nt long but cannot ident... | Are messenger RNA molecules epigenetically methylated? | 56d2ee61f22319765a000007_004 | yes |
Measles, measles vaccination, and risk of subacute sclerosing panencephalitis (SSPE). Between the years 1968 and 1979, 87 cases of subacute sclerosing panencephalitis (SSPE) appeared among the Israeli-born population. The incidence of SSPE dropped sharply in 1977, 10 years (the median age at onset of SSPE) after introd... | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | 5aa3fa73d6d6b54f79000008_017 | no |
Activation-dependent intrachromosomal interactions formed by the TNF gene promoter and two distal enhancers. Here we provide a mechanism for specific, efficient transcription of the TNF gene and, potentially, other genes residing within multigene loci. We identify and characterize highly conserved noncoding elements fl... | Do Conserved noncoding elements act as enhancers? | 5139ec51bee46bd34c000006_008 | yes |
Inverted repeats are necessary for circularization of the mouse testis Sry transcript. Circular non-polyadenylated RNA molecules have been identified as stable transcription products of the human ETS-1 and mouse Sry genes. RNA circularization has been proposed to require two steps. The first step utilizes intramolecula... | Is the mouse Sry gene locus free of repetitive sequences? | 58de34608acda3452900002b_005 | no |
The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation. Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damag... | Does the histone chaperone ASF1 interact with histones H1/H2? | 58dcbb8c8acda34529000021_014 | no |
Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication. Primers for vertebrate mitochondrial leading-strand DNA replication are products of transcription synthesized by mitochondrial RNA polymerase. The precursor primer RNA exists as a persistent RNA-DNA hybrid, known ... | Do R-loops tend to form at sites of DNA replication? | 56e2985951531f7e33000013_008 | yes |
IBD: Golimumab in ulcerative colitis: a 'ménage à trois' of drugs. Golimumab, a human anti-TNF antibody, is effective in patients with ulcerative colitis, according to new findings from an international phase III double-blind trial. The addition of this drug makes a ménage à trois of available drugs--comprising inflixi... | Is golimumab effective for ulcerative colitis? | 5896e4d478275d0c4a000015_006 | yes |
Sagittal synostosis in X-linked hypophosphatemic rickets and related diseases. BACKGROUND: The recent observations of two new cases of X-linked hypophosphatemic rickets associated with premature closure of the sagittal suture prompted a review of similar cases seen in this institution. OBJECTIVES: To review the clinica... | Could hypophosphatemic rickets cause craniosynostosis? | 58b9585c22d3005309000010_003 | yes |
EZH2 promotes proliferation and invasiveness of prostate cancer cells. BACKGROUND: The transcriptional repressor EZH2 is implicated in control of cell proliferation in embryonic, immortalized and transformed cells. EZH2 expression in prostate cancer correlates with progression to hormone-refractory and metastatic disea... | Is EZH2 associated with prostate cancer? | 570908e3cf1c325851000012_007 | yes |
A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy. Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both tumor-suppressive and tumor-promoting functions; both stimulation and inhibition of autopha... | Is autophagy the process where bacteria ingest viral particles? | 58dd2cb08acda34529000029_001 | yes |
Fingolimod treatment promotes regulatory phenotype and function of B cells. OBJECTIVE: To evaluate the influence of Fingolimod treatment on B-cell subset composition and function in multiple sclerosis patients and its potential clinical relevance. METHODS: Subset composition and cytokine production of B cells derived f... | Is there a relationship between B cells and Multiple Sclerosis? | 58c0836102b8c6095300001c_004 | yes |
Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects. Zolpidem [N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide hemitartrate] is reported to be a rapid onset, short duration hypnotic that interacts at the benzodiazepine recognition site. The present report es... | Is zolpidem an antibiotic? | 530cf4fe960c95ad0c00000a_001 | no |
A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stability. Nucleolin is a ubiquitously expressed protein and participates in many important biological processes, such as cell cycle regulation and ribosomal biogenesis. The acti... | Is SUMOylation a post-translational modification in eukaryotes? | 58a6b98860087bc10a000028_021 | yes |
ChIP-seq Analysis in R (CSAR): An R package for the statistical detection of protein-bound genomic regions. BACKGROUND: In vivo detection of protein-bound genomic regions can be achieved by combining chromatin-immunoprecipitation with next-generation sequencing technology (ChIP-seq). The large amount of sequence data p... | Does Chromatin Immunoprecipitation (ChIP) show a bias for highly expressed loci? | 52ef6da1c8da898910000011_002 | yes |
A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an autosomal dominant inherited disorder characterized by adrenergic induced... | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | 52e8e96698d023950500001f_018 | yes |
Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality. PURPOSE: Pentraxin 3 (PTX3) is an inflammatory mediator produced by neutrophils, macrophages, myeloid dendritic and endothelial cells. During sepsis a massive inflammatory activatio... | Can Pentraxin 3 predict outcomes of sepsis? | 5890eb22621ea6ff7e000006_006 | yes |
Drug-induced apoptosis was markedly attenuated in endometriotic stromal cells. BACKGROUND: The survival of endometriotic cells in the ectopic site has been investigated from the aspect of susceptibility of endometriotic tissues to apoptosis. In order to investigate the nature of abnormal survival of endometriotic cells... | Is Annexin V an apoptotic marker? | 5894597e7d9090f353000004_011 | yes |
The systematic analysis of ultraconserved genomic regions in the budding yeast. Motivation: In the evolution of species, a kind of special sequences, termed ultraconserved sequences (UCSs), have been inherited without any change, which strongly suggests those sequences should be crucial for the species to survive or ad... | Are there ultraconserved genomic regions in the budding yeast? | 5a6d217eb750ff4455000034_000 | yes |
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. Several neurological diseases, including Parkinson disease and dementia with Lewy bodies, are characterized by the accumulation of alpha-synuclein phosphorylated at Ser-129 (p-Ser-129). The kinase or kinases responsible fo... | Is PLK2 involved in alpha-synuclein phosphorylation in the nervous system? | 550c44d1a103b7801600000a_001 | yes |
[A case of Sjogren syndrome coexistent with MALT lymphoma occurring along the parotid gland and trachea]. A 62-year-old woman with Sjogren syndrome was admitted for computed tomographic (CT) evaluation of a thickened trachea and parotid tumor. She had been given a diagnosis of mucosa-associated lymphoid tissue (MALT) l... | Are patients with Sjogren syndrome at increased risk for lymphoma? | 5a6f87c5b750ff4455000056_003 | yes |
ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1. A recent genome-wide analysis indicated that a polymorphism (rs2535629) of ITIH3 showed the strongest association signal with susceptibility to psychiatric disorders in Caucasian populations. The aim of th... | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | 54d63d873706e89528000006_001 | yes |
FDA Approval Summary: Rucaparib for the Treatment of Patients with Deleterious BRCA Mutation-Associated Advanced Ovarian Cancer. On December 19, 2016, the FDA granted accelerated approval to rucaparib (RUBRACA; Clovis Oncology, Inc.) for the treatment of patients with deleterious BRCA mutation (germline and/or somatic)... | Is Rucaparib effective for ovarian cancer? | 5a7379a83b9d13c70800000a_005 | yes |
Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients. Deranged calcium-phosphate metabolism contributes to the burden of morbidity and mortality in dialysis patients. This study aimed to assess the association of the phosphaturic hormone fibroblast growth factor 23 (FGF2... | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | 570a5c27cf1c325851000023_004 | yes |
Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons. In the Drosophila germline, retrotransposons are silenced by the PIWI-interacting RNA (piRNA) pathway. Telomeric retroelements HeT-A, TART and TAHRE, which are involved in telomere maintenance in Drosophila, are also the targets of piRN... | Are piRNAs involved in gene silencing? | 56c6f6005795f9a73e000009_007 | yes |
Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity. Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA prof... | Is miR-21 related to carcinogenesis? | 511a4ec01159fa8212000004_013 | yes |
Diclofenac sodium, a nonselective nonsteroidal anti-inflammatory drug aggravates doxorubicin-induced cardiomyopathy in rats. The cardiotoxic effects of selective cyclo-oxygenase-2 inhibitors are well documented. Recently, concerns have been raised over the cardiovascular safety of nonselective nonsteroidal antiinflamma... | Is Doxorubicin cardiotoxic? | 58cdb80302b8c60953000043_016 | yes |
Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. Previous work has demonstrated the importance of protein kinase C in regulating glioma cell proliferation in vitro. Tamoxifen, a protein kinase C inhibitor when administered in high d... | Was tamoxifen tested for treatment of glioma patients? | 56c0968def6e394741000026_009 | yes |
New and emerging agents for the treatment of castration-resistant prostate cancer. Most men with recurrent prostate cancer (CaP) initially respond to androgen deprivation therapy but eventually develop metastatic castration-resistant prostate cancer (CRPC). Over the last decade, new therapeutic targets have been identi... | Has Denosumab (Prolia) been approved by FDA? | 52bf1db603868f1b06000011_018 | yes |
Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study. Overexpression of the DNA methyltransferase 3B (DNMT3B) gene and its effect on carcinogenesis has been demonstrated for various types of cancer. Recently, three single nucleotid... | Could DNA (cytosine-5-)-methyltransferases serve as tumour markers? | 5162e9df298dcd4e5100004b_008 | yes |
Effects of exercise on the levels of peptide YY and ghrelin. Ghrelin and peptide YY (PYY) are brain-gut peptides that have a variety of physiological functions and are involved in energy regulation. Thus far, abnormalities in the expression and secretion of ghrelin and PYY are known to occur in lifestyle-related diseas... | Does physical activity influence gut hormones? | 5158644cd24251bc0500008e_010 | yes |
Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action. Although resveratrol has been proven to possess diverse health benefits, several recent reports have demonstrated conflicting results on some aspects of its effects, including its anti-aging properties. Considerable debate ap... | Can FOXOs modulate longevity? | 52b2ec944003448f55000002_002 | yes |
RNA polyadenylation and degradation in cyanobacteria are similar to the chloroplast but different from Escherichia coli. The mechanism of RNA degradation in Escherichia coli involves endonucleolytic cleavage, polyadenylation of the cleavage product by poly(A) polymerase, and exonucleolytic degradation by the exoribonuc... | Is polyadenylation a process that stabilizes a protein by adding a string of Adenosine residues to the end of the molecule? | 5a8714e261bb38fb24000005_011 | no |
Characterization of a dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: comparison with a 6S-form. 6R-L-erythro-Tetrahydrobiopterin (6R-BH4) is a cofactor for aromatic L-amino acid hydroxylases and nitric oxide synthase. Recently, we have reported that independently of its cofactor activities, 6R-BH4 acts ... | Is NSD-1015 an inhibitor of Aromatic L-Amino Acid Decarboxylase? | 589c334e78275d0c4a00003d_026 | yes |
A novel host cell reactivation assay to assess homologous recombination capacity in human cancer cell lines. Repair of DNA double-strand breaks (DSB) is essential for cell viability and genome stability. Homologous recombination repair plays an important role in DSB repair and impairment of this repair mechanism may le... | Do DNA double-strand breaks play a causal role in carcinogenesis? | 5162f5b6298dcd4e5100004c_004 | yes |
Surgical treatment of ocular melanoma. Malignant melanomas may arise in the uveal tract, the conjunctiva, the skin of the eyelid, or the orbit. Risk factors so far identified include pre-existing choroidal naevi for uveal melanomas, primary acquired melanosis (PAM) for conjunctival tumours, and ocular and oculodermal m... | Is ocular melanosis a risk factor for uveal melanoma? | 58b5320e22d3005309000002_002 | yes |
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs. Several multiple, large-scale, genetic studies on autoimmune-disease-associated SNPs have been reported recently: peptidylarginine deiminase type 4 (PADI4) in rheumatoid arthritis (RA); solute carrier family 22 members 4 and 5 (SLC22A4 and 5)... | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | 52e7870a98d023950500001a_038 | yes |
[Chemotherapy and targeted treatments in glioblastomas]. BACKGROUND AND PURPOSE: We review the indications and limitations of chemotherapy in glioblastoma multiform (GBM), including the role played by alkylating and other cytotoxic agents and the increased input of clinical research on targeted agents in GBM management... | Is enzastaurin effective treatment of glioblastoma? | 5a7612b483b0d9ea6600001d_006 | no |
Soil Nutrient Depletion Is Associated with the Presence of Burkholderia pseudomallei. Burkholderia pseudomallei is a soil-dwelling bacterium and the cause of melioidosis, which kills an estimated 89,000 people per year worldwide. Agricultural workers are at high risk of infection due to repeated exposure to the bacteri... | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | 58caf88c02b8c60953000031_006 | yes |
Epigenetic modifications in cardiovascular disease. Epigenetics represents a phenomenon of altered heritable phenotypic expression of genetic information occurring without changes in DNA sequence. Epigenetic modifications control embryonic development, differentiation and stem cell (re)programming. These modifications ... | Are epigenetic modifications implicated in cardiovascular development and disease? | 54f7291630767eb92e000002_000 | yes |
Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. Accumulating evidence indicates that cytoskeletal defects may be an important pathway for dilated cardiomyopathy and eventual heart failure. Targeted disruption of muscle LIM protein (MLP) has previously been shown to result in dilated... | Is muscle lim protein (MLP) involved in cardiomyopathies? | 54f704b630767eb92e000001_008 | yes |
A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy. BACKGROUND: Fatigue is common among glioma patients undergoing radiotherapy (RT) and impacts quality of life (QOL). We evaluated whether armodafinil, a wakefulness-promoting medication, improves fat... | Does armodafinil improve fatigue of glioma patients? | 5a76072283b0d9ea66000013_000 | no |
A randomized, double-blind, placebo-controlled 6-wk trial of the efficacy and tolerability of 5 mg vortioxetine in adults with major depressive disorder. Vortioxetine (Lu AA21004) is a multi-modal antidepressant in clinical development for the treatment of major depressive disorder (MDD). The current study evaluated th... | Is Vortioxetine effective for treatment of depression? | 53359338d6d3ac6a3400004f_006 | yes |
Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans. Endostatin is a potent inhibitor of angiogenesis and tumor growth. Here, we used human endothelial cells from lung capillaries to investigate if endostatin competes with the proangiogenic growth factors, bFGF and VEGF, for binding to costimul... | Is endostatin a proangiogenic factor? | 53124e84e3eabad02100000c_013 | no |
Cardiovascular events in thyroid disease: a population based, prospective study. No consensus exists whether subclinical thyroid disease should be treated or just observed. Untreated overt thyroid disease is associated with increased risk of cardiovascular disease, and this study was conducted to assess the risk of car... | is pharmacological treatment of subclinical hypothyroidism effective in reducing cardiovascular events? | 52d7b45e98d0239505000002_001 | no |
Optogenetic control of astrocytes: is it possible to treat astrocyte-related epilepsy? Epilepsy is a neurological disorder that affects around 1% of the population worldwide. The two main therapies, pharmacology and the electrical stimulation, both have some shortcomings. For instance, pharmacological therapy is freque... | Are optogenetics tools used in the study and treatment of epilepsy? | 56e0797451531f7e3300000f_008 | yes |
Desvenlafaxine succinate: a newer antidepressant for the treatment of depression and somatic symptoms. Desvenlafaxine succinate (DVS) is one of several serotonin-norepinephrine reuptake inhibitors (SNRIs). Others are venlafaxine hydrochloride, milnacipran, and duloxetine. Desvenlafaxine has been approved by the US Food... | Can desvenlafaxine be used at a dose of 50mg/day? | 530cf4fe960c95ad0c00000c_008 | yes |
The role and efficacy of denosumab in the treatment of osteoporosis: an update. INTRODUCTION: Bone strength determinants such as bone mineral density and bone quality parameters are determined by life-long remodeling of skeletal tissue. Denosumab is a fully human mAb receptor activator of NF-κB ligand, which selectivel... | Has Denosumab (Prolia) been approved by FDA? | 52bf1db603868f1b06000011_000 | yes |
Treatment for periodic paralysis. BACKGROUND: Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. OBJECTIVES: The objective of this review was... | Is dichlorphenamide effective for periodic paralysis? | 56c1d841ef6e39474100002d_004 | yes |
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). Subacute (de Quervain's) thyroiditis is a rare but important cause of fever of unknown origin. Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Bar... | Is paramyxovirus involved in human subacute thyroiditis? | 513efe01bee46bd34c00000e_001 | no |
Nuclear binding sites for triiodothyronine in the gerbil brain following ischemia and recirculation. The effect of cerebral ischemia and subsequent recirculation on the nuclear thyroid hormone receptors was investigated. Ischemia was produced by occlusion of the right common carotid artery in the Mongolian gerbil. The ... | Do thyroid hormone receptors change after brain injury? | 533e50fdc45e13371400000f_002 | yes |
Time course and mechanisms of phosphorylation of phospholamban residues in ischemia-reperfused rat hearts. Dissociation of phospholamban phosphorylation pathways. Sarcoplasmic reticulum (SR) dysfunction is one of the multiple alterations that occurs in ischemia-reperfused hearts. Because SR function is regulated by pho... | Is phospholamban phosphorylated by Protein kinase A? | 54da0c524b1fd0d33c00000b_008 | yes |
Denaturing high-performance liquid chromatography (DHPLC)-based prenatal diagnosis for tuberous sclerosis. Tuberous sclerosis (TSC) is a frequent autosomal-dominant condition (affecting 1 in 6000 individuals) caused by various mutations in either the hamartin (TSC1) or the tuberin gene (TSC2). This allelic and non-alle... | Is Tuberous Sclerosis a genetic disease? | 52b06a68f828ad283c000005_027 | yes |
What happens before the onset of rheumatoid arthritis? PURPOSE OF REVIEW: To give an overview of publications on presence of autoantibodies, rheumatoid factor and anticitrullinated protein/peptide antibodies (ACPAs) and their relationships to genetic markers and soluble factors as indicators of immune activation and id... | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | 52e7870a98d023950500001a_023 | yes |
Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis. To investigate a possible association between functional polymorphisms of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22-R620W) and receptors for the Fc fragment of IgG (FcgRIIa-H131R, FcgRIIIa-F158V FcgRIIIb... | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | 52e7870a98d023950500001a_031 | yes |
Endocrine and metabolic responses to extreme altitude and physical exercise in climbers. CONTEXT: Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. OBJECTIVE: To further investigate the endocrine and metabolic responses to extreme HA. M... | Does strenuous physical activity affect thyroid hormone metabolism? | 51598b08d24251bc0500009f_007 | yes |
Advanced cytoreduction as surgical standard of care and hyperthermic intraperitoneal chemotherapy as promising treatment in epithelial ovarian cancer. Favorable oncological outcomes have been reported in several trials with the introduction of Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (H... | Could Hyperthermic intraperitoneal chemotherapy (HIPEC) be effective for the treatment of recurrent ovarian cancer? | 553fb11fc6a5098552000003_005 | yes |
Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use. INTRODUCTION: Poly(ADP-ribose) polymerase (PARP) inhibitors are a targeted therapy option for ovarian cancer. The goal of this review was to organize and summarize the clinical trials evaluating PARP inhibitor therapy in ovarian ... | Is Rucaparib effective for ovarian cancer? | 5a7379a83b9d13c70800000a_000 | yes |
Imaging C. elegans embryos using an epifluorescent microscope and open source software. Cellular processes, such as chromosome assembly, segregation and cytokinesis,are inherently dynamic. Time-lapse imaging of living cells, using fluorescent-labeled reporter proteins or differential interference contrast (DIC) microsc... | Has the protein GFP been used in transgenesis for live protein imaging? | 5523e8cc7b523f2123000007_005 | yes |
Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial. BACKGROUND: There has been recent interest in the possible role of reperfusion-induced inflammation with neuronal injury after stroke. Enlimomab, a murine intercellular adhesion molecule-1 (ICAM-1) antibody, reduces leukocyte ad... | Is Enlimomab effective for stroke treatment? | 58ec6eb5eda5a5767200000c_003 | no |
Role of musclin in the pathogenesis of hypertension in rat. Musclin is a novel skeletal muscle-derived secretory factor found in the signal sequence trap of mouse skeletal muscle cDNAs. Musclin possesses a region homologous to the natriuretic peptide family. Thus, musclin is found to bind with the natriuretic peptide c... | Is Musclin a secretory peptide? | 58df779d6fddd3e83e000001_004 | yes |
Low clinical burden of 2009 pandemic influenza A (H1N1) infection during pregnancy on the island of La Réunion. BACKGROUND: Pregnant women have been identified as a group at risk, both for respiratory complications than for the admissions to the Intensive Care Unit (ICU) during the 2009 H1N1 influenza pandemic (pdm). T... | Is pregnancy an additional risk during during H1N1 infection? | 531a3fe3b166e2b806000038_015 | yes |
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