Molecule name
stringlengths
9
9
SMILES
stringlengths
22
88
MLM CLint
float64
0
10.4k
E-0011212
Cc1c2ccnc(C(=O)N[C@H](C)CN(C)C)c2cc2c3cc(OCC(N)=O)ccc3n(C)c12
1,577.6
E-0011213
Cc1c2ccnc(C(=O)N[C@H](C)CN(C)C)c2cc2c3cc(OC[C@H](C)N)ccc3n(C)c12
361.5
E-0011214
CC(=O)N[C@@H](C)COc1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
653.2
E-0011215
Cc1c2ccncc2cc2c3cc(OC[C@H](C)NC(N)=O)ccc3n(C)c12
491.5
E-0011216
NC(=O)Cn1ccc2ccc(-c3ccccc3)cc21
1,073.4
E-0011217
Cc1nc(NC(=O)NCCN(C)C)cc2c3cc(OCC4=NCCN4)ccc3n(C)c12
387.8
E-0011219
Cc1c2ccncc2cc2c3cc(OCCC(C)(C)N)ccc3n(C)c12
130.6
E-0011225
Cc1nc(NC(=O)NCCN(C)C)cc2c3cc(OCC(N)=O)ccc3n(C)c12
166.2
E-0011226
CCN[C@@H](C)COc1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
279.6
E-0011227
CN[C@@H](C)COc1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
265.2
E-0011232
CCCN[C@@H](C)COc1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
240.6
E-0011233
COCCN[C@@H](C)COc1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
239
E-0011234
Cc1c2ccncc2cc2c3cc(OC[C@H](C)NCC(F)F)ccc3n(C)c12
1,418.1
E-0011235
Cc1nc(C(N)=O)cc2c3cc(OC[C@H](C)N)ccc3n(C)c12
383.3
E-0011236
Cc1c2ccncc2cc2c3cc(C(=O)NC[C@H](C)N)ccc3n(C)c12
156.6
E-0011240
Cc1c2ccncc2cc2c3cc(C(=O)N[C@@H](C)CN)ccc3n(C)c12
245.5
E-0011241
Cn1c2ccc(OCC3=NCCN3)cc2c2cc(C(N)=O)ccc21
914.5
E-0011242
Cc1c2ccncc2cc2c3cc(C(=O)N[C@H](C)CN)ccc3n(C)c12
444.9
E-0011243
Cc1c2ccncc2cc2c3cc(OC[C@H](C)NC(C)C)ccc3n(C)c12
175.4
E-0011246
Cn1c2ccc(OCC(N)=O)cc2c2cc(-c3ccccc3)ccc21
435.7
E-0011247
C[C@H](N)COc1ccc2c(c1)c1cc(C(N)=O)ccc1n2C
1,377.7
E-0011248
Cn1c2ccc(OCC(N)=O)cc2c2cc(-c3ccncc3)ccc21
265
E-0011249
Cc1c2ccncc2cc2c3cc(C(=O)NC[C@@H](C)N)ccc3n(C)c12
264.8
E-0011250
Cc1c2ccncc2cc2c3cc(C(=O)NC[C@@H](C)O)ccc3n(C)c12
729.6
E-0011251
Cc1c2ccncc2cc2c3cc(C(=O)N[C@H](C)CN(C)C)ccc3n(C)c12
1,401
E-0011252
Cc1c2ccncc2cc2c3cc(C(=O)NC[C@H](C)O)ccc3n(C)c12
721.4
E-0011253
C[C@H](N)COc1ccc2c(c1)c1nc3cnccc3nc1n2C
346.6
E-0011255
COC[C@H](C)NC(=O)c1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
1,409.6
E-0011256
Cn1c2ccc(OCC(N)=O)cc2c2nc3cnccc3nc21
1,132.5
E-0011259
NCCCNc1nc(NC(=O)OCCCN)cc2c(-c3ccnc(N4CCNCC4)c3)cccc12
61.1
E-0011261
Cc1nc(CCC(=O)Nc2ccccn2)cc2c3cc(OC[C@H](C)N)ccc3n(C)c12
1,061.3
E-0011262
Cc1c2ccncc2cc2c3cc(C(=O)N[C@H](C)CO)ccc3n(C)c12
1,377.9
E-0011263
Cc1c2ccnc(C(=O)NCC(N)=O)c2cc2c3ccccc3n(C)c12
835.3
E-0011264
Cc1c2ccncc2cc2c3cc(C(=O)N[C@@H](C)CO)ccc3n(C)c12
1,249.3
E-0011265
Cc1c2ccnc(C(=O)N[C@H](C)CN(C)C)c2cc2c3ccccc3n(C)c12
2,626.3
E-0011266
Cc1nc(CCCNc2ccccn2)cc2c3cc(OC[C@H](C)N)ccc3n(C)c12
1,740.2
E-0011267
C[C@H](N)COc1ccc2c(c1)c1ccc(-c3cccnc3)cc1n2C
97.8
E-0011268
Cc1c2ccccc2cc2c3cc(OC[C@H](C)N)ccc3n(C)c12
70.4
E-0011270
C[C@H](N)COc1ccc2c(c1)c1cc(-c3ccncc3)ccc1n2C
190.1
E-0011271
Cc1c2ccccc2cc2c3cc(OCC4=NCCN4)ccc3n(C)c12
658.4
E-0011272
Cn1c2ccc(OCC(N)=O)cc2c2ccc(-c3cccnc3)cc21
146.7
E-0011273
Cc1c2ccnc(C(=O)NCCN)c2cc2c3ccccc3n(C)c12
441.4
E-0011276
C[C@H](N)COc1ccc2c(c1)c1ccc(-c3ccncc3)cc1n2C
104
E-0011277
Cc1c2ccncc2cc2c3cc(C(=O)NC[C@@H](C)N(C)C)ccc3n(C)c12
263.2
E-0011279
Cc1c2ccncc2cc2c3cc(C(=O)N[C@@H](C)CN(C)C)ccc3n(C)c12
456.7
E-0011280
Cn1c2ccc(OCC(N)=O)cc2c2nc3ccccc3nc21
288.6
E-0011282
Cn1c2ccc(OCCN3CCCCC3)cc2c2nc3ccccc3nc21
1,648.1
E-0011283
CCN(CC)CCOc1ccc2c(c1)c1nc3cnccc3nc1n2C
535.2
E-0011285
Cc1c2ccncc2cc2c3cc(C(=O)NCC(N)=O)ccc3n(C)c12
793.4
E-0011286
Cc1c2ccncc2cc2c3cc(C(=O)N[C@@H](C)C(N)=O)ccc3n(C)c12
774.6
E-0011287
Cc1c2ccccc2cc2c3cc(OCC(N)=O)ccc3n(C)c12
99.3
E-0011288
Cc1c2ccncc2cc2c3cc(C(=O)N[C@H](C)C(N)=O)ccc3n(C)c12
613.7
E-0011289
COC(C)(C)CNC(=O)c1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
1,604
E-0011290
CCN(CC)CCCOc1ccc2c(c1)c1nc3cnccc3nc1n2C
569.9
E-0011291
Cn1c2ccc(OCC(N)=O)cc2c2nc3cnccc3cc21
1,661.1
E-0011292
Cn1c2ccc(OCCN3CCCCC3)cc2c2nc3cnccc3cc21
661.2
E-0011293
Cn1c2ccc(C(=O)NCCO)cc2c2nc3ccccc3nc21
394.3
E-0011294
COC1CCN(CCOc2ccc3c(c2)c2nc4cnccc4nc2n3C)CC1
550.1
E-0011295
Cn1c2ccc(OCCN3CCC(F)CC3)cc2c2nc3cnccc3nc21
1,091.5
E-0011296
CN[C@@H](C)COc1ccc2c(c1)c1nc3cnccc3nc1n2C
520.5
E-0011297
Cc1c2ccncc2cc2c3cc(C(=O)NC[C@H](C)N(C)C)ccc3n(C)c12
300.4
E-0011298
Cc1c2ccncc2cc2c3cc(C(=O)NCCOC(C)(C)C)ccc3n(C)c12
7,870.9
E-0011299
COCC(C)(C)NC(=O)c1ccc2c(c1)c1cc3cnccc3c(C)c1n2C
8,093.2
E-0011300
Cn1c2ccc(OCCN3CCCC3)cc2c2nc3cnccc3nc21
594.2
E-0011301
Cn1c2ccc(OCCN3CCOCC3)cc2c2nc3cnccc3cc21
1,345.8
E-0011302
Cn1c2ccc(OCCCN3CCCCC3)cc2c2nc3cnccc3nc21
597.5
E-0011303
Cn1c2ccc(OCCCCN3CCCCC3)cc2c2nc3cnccc3nc21
802.8
E-0011304
C[C@H](N)COc1ccc2c(c1)c1cc(-c3ccccc3)ccc1n2C
46.7
E-0011305
COc1cccc(-c2cn(C)c3ccc(OCCCN4CCCC4)cc23)c1
4,514.3
E-0011306
COc1cncc(-c2cn(C)c3ccc(OCCCN4CCCC4)cc23)c1
2,654.8
E-0011308
CC(C)N[C@@H](C)COc1ccc2c(c1)c1nc3cnccc3nc1n2C
821.9
E-0011309
CN1CCN=C1COc1ccc2c(c1)c1nc3cnccc3nc1n2C
459.5
E-0011310
CCCN[C@@H](C)COc1ccc2c(c1)c1nc3cnccc3nc1n2C
704.4
E-0011311
Cn1c2ccc(OCCCN3CCCC3)cc2c2nc3cnccc3nc21
661.1
E-0011312
Cn1c2ccc(OCCCCN3CCCC3)cc2c2nc3cnccc3nc21
747.4
E-0011313
C[C@@H](COc1ccc2c(c1)c1nc3cnccc3nc1n2C)N1CCCCC1
964.7
E-0011314
C[C@H](N)COc1ccc2c(c1)c1nc3cnccc3cc1n2C
300.3
E-0011315
Cn1c2ccc(OC[C@@H]3CCCN3)cc2c2nc3cnccc3nc21
428.3
E-0011316
Cn1cc(-c2cccnc2)c2cc(OCCCN3CCCC3)ccc21
4,087.9
E-0011317
Cc1cc(C#N)cc2c3cc(OCCCN4CCCC4)ccc3n(C)c12
636.5
E-0011335
Cc1ccc(CNc2cc(-c3ccccc3)[nH]c(=O)n2)cc1
715.3
E-0011365
COc1cccc(Nc2nc(-c3ccccc3)cs2)c1
2,121.2
E-0011366
COc1ccc(-c2csc(Nc3ccccn3)n2)cc1
2,157.8
E-0011626
Cc1c2ccncc2cc2c3cc(Oc4ccnc(N)c4)ccc3n(C)c12
833.2
E-0011627
Cc1c2ccncc2cc2c3cc(Oc4cccc(N)n4)ccc3n(C)c12
792.2
E-0011628
Cc1c2ccncc2cc2c3cc(Oc4ccccn4)ccc3n(C)c12
808.7
E-0011629
COCCNC(=O)c1ccc2c(c1)c1nc3cnccc3nc1n2C
622.8
E-0011630
Cc1c2ccncc2cc2c3cc(Oc4ccncc4)ccc3n(C)c12
492.1
E-0011631
Cc1c2ccnc(C(=O)N[C@H](C)CN(C)C)c2cc2c3cc(F)c(F)cc3n(C)c12
937.8
E-0011632
Cn1c2ccc(OCCNC3CCC(F)(F)CC3)cc2c2nc3cnccc3nc21
718.4
E-0011633
Cc1c2ccnc(C(=O)NCCN)c2cc2c3cc(F)ccc3n(C)c12
316.9
E-0011634
Cn1c2ccc(OCC(N)=O)cc2c2cc3ccccc3nc21
494.5
E-0011635
Cc1c2ccnc(C(=O)NCCN)c2cc2c3cc(F)c(F)cc3n(C)c12
80.7
E-0011636
Cn1c2ccc(OCCNC3CCOCC3)cc2c2nc3cnccc3nc21
452.9
E-0011637
Cc1cc(-n2cccn2)cc2c3cc(OCCCN4CCCC4)ccc3n(C)c12
1,769.5
E-0011638
Cc1cc(-n2ccnc2)cc2c3cc(OCCCN4CCCC4)ccc3n(C)c12
226.6
E-0011639
Cn1c2ccc(OCCN3CCCCC3)cc2c2cc3ccccc3nc21
1,484.7
E-0011640
Cn1c2ccc(OCC3=NCCN3)cc2c2nc3cnccc3cc21
642.4
E-0011641
Cn1c2ccc(OCCN3CCCCC3)cc2c2nc3cc(Cl)c(Cl)cc3nc21
49.8
E-0011642
Cn1c2ccc(OCCN3CCCCC3)cc2c2cc(-c3ccncc3)ccc21
345.3