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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 19.0-40.0, Epidural Anesthesia Spinal Ultrasound American Society of Anesthesiologists class I or II Full term parturients scheduled for elective cesarean delivery under combined spinal-epidural anesthesia Body mass index ≥ 35 kg/m2 Patients having any contraindication to neuraxial anesthesia (Refusal of the procedure, Coagulopathy, Uncorrected hypovolemia, Increased intracranial pressure, Local skin infection) Marked spinal deformity or previous spinal surgery Unpalpable anatomical landmarks Emergent situations
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 1.0-6.0, Pain Patients with American Society of Anesthesiologists (ASA) Scheduled for lower abdominal and perineal surgery Under general anesthesia Hypersensitivity to any local anesthetics Patient has history of allergy, intolerance, or reaction to dexmedetomidine Infections at puncture sites Bleeding diathesis Preexisting neurological disease Children with uncorrected cardiac lesions Children with heart block
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 75.0-999.0, Post-operative Cognitive Dysfunction any patient aged 75 years and more scheduled for elective non-cardiac surgery under general anesthesia Failure to obtain informed consent to the study Impossibility to perform scheduled geriatric and neuropsychological tests during the preoperative evaluation Mini-mental state examination score (corrected for age and education) ≤ 23 at the preoperative evaluation Patients scheduled to undergo intracranic neurosurgical procedures or vascular surgery Patients who have been subjected to a surgical procedure under general anesthesia in the preceding 6 months Patients with metastatic cancer; patients falling in the category of the American Society of Anaesthesiologists (ASA) physical status 4 Patients already included in the study, i.e. second surgical procedure; for the Control Group: • Subjects of 75 years and more in whom no hospitalization or surgical procedure is scheduled in the following 3 months for the Control Group Failure to obtain informed consent to the study Impossibility to perform scheduled geriatric and neuropsychological tests during the baseline evaluation
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-50.0, Myofascial Pain Syndrome The participants have experienced spontaneous upper back pain for longer than 12 weeks (chronic) and that at least one trigger point will be present in the s trapezius muscles. Trigger points will be diagnosed as the presence of focal tenderness in a taut band and with pain recognition The participants will be able to follow instructions Good communication and cooperation Fibromyalgia syndrome Cervical radiculopathy or myelopathy) Cervical spine surgery
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-30.0, Local Anesthesia ASA I full maxillary dental arch vital maxillary teeth without caries, restorations, periodontal disease or history of trauma allergies to local anesthetic solution ingredients, food and drugs alcohol and drugs abuse heavy tobacco smoking
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Abdomen Acute Appendicitis Patient presented with the complaint of right lower abdominal pain Suspected acute appendicitis Flank pain Previous appendectomy Pregnancy Unstable vital signs Frank peritonitis US performed before EP's examination
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.25-17.0, Complicated Intra-abdominal Infections Must be ≥3 calendar months to <18 years of age. Patients aged ≥3 calendar months to <1 year must have been born at term (defined as gestational age ≥37 weeks). 2. Written informed consent from parent(s) or other legally acceptable representative(s), and informed assent from patient (if age appropriate according to local regulations) 3. If female and has reached menarche, or has reached Tanner stage 3 development (even if not having reached menarche) (refer to Appendix E for further details on Tanner staging), the patient is authorised to participate in this clinical study if the following are met: At screening: (i) Patient reports sexual abstinence for the prior 3 months or reports use of at least 1 of the acceptable methods of contraception, including an intrauterine device (with copper banded coil), levonorgestrel intrauterine system (eg, Mirena®), or regular medroxyprogesterone injections (Depo-Provera®); or (b) Patient agrees to initiate sexual abstinence from the time of screening until 7 days after end of treatment with study drug; and (ii) Patient is advised to avoid conception from the time of screening until 7 days after receipt of study drug and agrees not to attempt pregnancy from the time of screening until 7 days after end of treatment with study drug; and (iii) Patient is provided guidelines regarding continuation of abstinence, initiation of abstinence, or about allowed contraception; and (iv) Patient has a negative serum β-human chorionic gonadotropin (β-hCG) test just prior to study entry. Since serum tests may miss an early pregnancy, relevant menstrual history and sexual history, including methods of contraception, should be considered. Note: if the result of the serum β-hCG test cannot be obtained prior to dosing of investigational product, a patient may be enrolled on the basis of a negative urine pregnancy test, though a serum β-hCG test result must still be obtained. 4. Must, based on the judgment of the Investigator, require hospitalisation initially and antibacterial therapy for 7 to 15 days in addition to surgical intervention for the treatment of the current cIAI 5. Require surgical intervention (eg, laparotomy, laparoscopic surgery or percutaneous drainage) to manage the cIAI 6. Must have clinical evidence of cIAI as follows: (i) Pre-operative enrolment 1. Requires surgical intervention that is expected to be completed within 24 hours of enrolment Laparotomy, laparoscopy, or percutaneous drainage 2. Evidence of a systemic inflammatory response (at least 1): Fever (defined as oral temperature >38.5°C, or equivalent to method used) or hypothermia (with a core body or rectal temperature <35°C, or equivalent to method used) Elevated white blood cells (WBC) (>15000 cells/mm3) C-reactive protein (CRP) levels (>10 mg/L) 3. Physical Findings consistent with intra-abdominal infection, such as: Abdominal pain and/or tenderness Localised or diffuse abdominal wall rigidity Abdominal mass 4. Intention to send specimens from the surgical intervention for culture 5. (Optional) Supportive radiologic findings of intra-abdominal infection, such as perforated intraperitoneal abscess detected on: Computed tomography (CT) scan or Magnetic resonance imaging (MRI) or Ultrasound (ii) Intra-operative/postoperative enrolment inclusion(in cases of postoperative enrolment, must be within 24 hours after the time of incision):: Visual confirmation of intra-abdominal infection associated with peritonitis at laparotomy, laparoscopy or percutaneous drainage (to be confirmed pending feasibility); must have 1 of these diagnoses: 1. Appendiceal perforation or peri-appendiceal abscess 2. Cholecystitis with gangrenous rupture or perforation or progression of the infection beyond the gallbladder wall 3. Acute gastric or duodenal perforations, only if operated on >24 hours after singular perforation occurs 4. Traumatic perforation of the intestines, only if operated on >12 hours after perforation occurs 5. Secondary peritonitis (but not spontaneous bacterial peritonitis associated with cirrhosis and chronic ascites) Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site) 2. Previous enrolment or randomisation in the present study 3. Participation in another clinical study with an investigational product (IP) during the last 30 days before the first dose of IV study drug or have previously participated in the current study or in another study of CAZ-AVI (in which an active agent was received) 4. History of hypersensitivity reactions to carbapenems, cephalosporins, penicillin, other β lactam antibiotics metronidazole or to nitroimidazole derivatives 5. Concurrent infection, that may interfere with the evaluation of response to the study antibiotics at the time of randomisation 6. Patient needs effective concomitant systemic antibacterials (oral, IV, or intramuscular) in addition to those designated in the 2 study groups (CAZ-AVI plus metronidazole group or meropenem group) (see Section 7.8) 7. Receipt of non-study systemic antibacterial drug therapy for cIAI for a continuous duration of more than 24 hours during the 72 hours preceding the first dose of IV drug, except in proven resistant organisms and/or worsening of the clinical condition for more than 24 hours. More than 2 consecutive doses are not permitted if the individual doses are expected to give >12 hours' cover (ie, giving a total cover of >24 hours.) For patients enrolled after a surgical procedure, only 1 dose of non study antibiotics is permitted postoperatively 8. Patient is considered unlikely to survive the 6 to 8 week study period 9. Patient is unlikely to respond to 7 to 15 days of treatment with antibiotics 10. Patient is receiving haemodialysis or peritoneal dialysis 11. Diagnosis of abdominal wall abscess confined to musculature of the abdominal wall or ischaemic bowel disease without perforation, traumatic bowel perforation requiring surgery within 12 hours of perforation, or perforation of gastroduodenal ulcers requiring surgery within 24 hours of perforation (these are considered situations of peritoneal soiling before the infection has become established) 12. Simple (uncomplicated), non-perforated appendicitis or gangrenous appendicitis without rupture into the peritoneal cavity identified during a surgical procedure OR presence of primary peritonitis (ie, spontaneous bacterial peritonitis) or peritonitis associated with cirrhosis or chronic ascites 13. At the time of randomisation, patient is known to have a cIAI caused by pathogens resistant to the study antimicrobials planned to be used in the study 14. Presence of any of the following clinically significant laboratory abnormalities: 1. Haematocrit <25% or haemoglobin <8 g/dL (<80g/L , <4.9 mmol/L) 2. Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3×the age-specific upper limit of normal (ULN), or total bilirubin >2×ULN (except known Gilbert's disease) For a) to b): unless if these values are acute and directly related to the infectious process being treated. 15. Creatinine clearance<30 mL/min /1.73 m2 calculated using the child's measured height (length) and serum creatinine within the updated "bedside" Schwartz formula (Schwartz et al, 2009): CrCl (mL/min/1.73m2)=0.413×height (length) (cm)/serum creatinine (mg/dL) 16. History of seizures, excluding well-documented febrile seizure of childhood 17. Any situation or condition that would make the patient, in the opinion of the Investigator, unsuitable for the study (eg, would place a patient at risk or compromise the quality of the data) or may interfere with optimal participation in the study 18. If female, currently pregnant or breast feeding
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 9.0-17.0, Post Operative Pain Appendicitis Patients undergoing Appendectomy for acute non-perforated appendicitis Must be between 9-17 years old n/a
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 14.0-999.0, Appendicitis age 14 years to 120 years patients that underwent an ultrasound exam that proved to be equivocal or not diagnostic patients who were sent to perform a CT scan that includes drinking oral contrast material pregnant patients patients with known allergy to oral contrast material (TELEBRIX gastro)
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Resident Education and Assessment of Difficult and High Acuity Scenarios That Focus on Cardiac Anesthesia Resident physicians who have completed at least one month of cardiac rotation are included.This high fidelity simulation lab course if offerred to every resident that meets the criteria.This is a part of their educational activity.At the beginning of the course they are given the option to participate in the survey.If they do not wish to participate in the survey it will not affect their education.Participitaion in the survey is purely voluntary Resident physicians that did not wish to participate in filling out the survey or not able to fill out the survey
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-35.0, G.I.T. Motility After General Versus Spinal Anaesthesia Patients set for planned cesarean section under general or spinal anesthesia: 1. age from 18 to 37 years. 2. Full term(37-41 weeks). 3. Singleton pregnancy. 4. Hemoglobin level more than 11 gm/dl Contraindication to regional anesthesia i.e(patient refusal,coagulopathy,significant hypovolemia,systemic or local sepsis,increased intracranial pressure,severe stenotic valvular heart disease,pre existing neurologic conditions and local anesthetic or fentanyl allergy. 2. High risk pregnancies as pre eclampsia,eclampsia,any medical disorder(DM,cardiac and thyroid diseases). 3. Previous intestinal surgery,previous C.S. and previous gynecological operations
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Irritable Bowel Syndrome Patients meeting IBS Rome III criteria. Asymptomatic individuals for health surveillance or patients for follow up after polypectomy Patients with known cancers or abdominal surgery. Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. Patients who are unwilling to sign or give the informed consent form. Patients with impaired cardiac, liver or renal function. Patients with coagulopathy. Patients with pregnancy or breastfeeding
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Automated Measurement of Vital Signs Adult male and female hospital in-patients Vital signs considered 'stable' by clinical caregivers Pediatric patients Female patients who are pregnant Patients with internal or external defibrillators Patients who have undergone surgery and still have a fresh incision on the chest Patients with skin damage on the chest such as burns, irritation, infections, wounds, etc Patients who are in the Critical Care Unit (CCU) Patients who otherwise satisfy any of the contraindications associated with the VSP system
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Appendicitis Other and Unspecified Acute Appendicitis Acute Disease Gastrointestinal Diseases Intra-abdominal Infection Age 18-60 years Clinical suspicion of acute uncomplicated appendicitis based on history, physical examination, laboratory findings evaluated by a senior surgeon Age <18 years or > 60 years Pregnancy or breastfeeding Allergy to contrast material or iodine History of appendectomy Renal failure, creatinine-value greater than the upper reference value Diabetes mellitus and metformin medication Suspicion of peritonitis and appendiceal perforation Incapability to cooperate and give consent to participate in the study A severe generalized disease or condition
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Abdominal Pain Pelvic Pain Age >= 18 years old female ED bedside transvaginal ultrasound to be performed in a non-pregnant woman with at least one ovary Willing to discuss how they are doing at 7-10 days via phone Valid phone number If a diagnosis of ovarian torsion, mass, TOA or other ovarian pathology is known before ED ultrasound Previously enrolled in this study
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Morton's Neuroma Male or female subjects aged >/=18 years at the time of the Screening Visit. 2. Symptoms of intermetatarsal neuroma for at least 30 days prior to the Screening Visit. 3. Diagnosis of intermetatarsal neuroma (Morton's neuroma) based on medical history and physical examination with evidence of focal tenderness and pain in the area of the neuroma, confirmed by ultrasound or other imaging modality. Typically the subject will have sensory symptoms in the distribution of the affected common digital nerve. However, provided the imaging study is positive, the presence of these sensory symptoms is not required. The neuroma may be in either the second or third intermetatarsal space. 4. An average pain score of 4.0 to 9.0 (during the 7 days prior to dosing) on the Numeric Pain Rating Scale (NPRS), as rated daily at bedtime for average pain while walking in the last 24 hours, relevant to the affected foot. At least 4 of 7 scores during the week prior to dosing must be recorded. 5. For female subjects: reproductive status is such that the subject is surgically sterile, at least 2 years postmenopausal, or using a medically acceptable method of birth control; if of child-bearing potential, is not pregnant (negative urine pregnancy test prior to enrollment), is not planning to get pregnant during the course of the study, and is not lactating. 6. Willing and able to understand the study requirements, abide by the study restrictions, complete the study procedures, pain scales, and diaries, and to communicate meaningfully with the study personnel. 7. Signed an Informed Consent Form approved by the Institutional Review Board Clinically significant bursitis or another significant symptomatic condition in the region of or adjoining the neuroma. 2. The subject has more than one intermetatarsal neuroma on the foot to be injected (index foot). 3. Prior use of injection with a sclerosing agent such as alcohol or phenol, or prior surgery for intermetatarsal neuroma on the affected foot. 4. Prior injection of corticosteroid in the index foot or oral use of corticosteroids within 30 days of screening. 5. The subject has another painful condition that, in the judgment of the investigator, would interfere with the subject's ability to evaluate the pain and functional limitations that arise from the intermetatarsal neuroma. 6. Other painful foot pathology (e.g., bunion, hammertoe, plantar fasciitis, etc.) or evidence of clinically meaningful ischemia which in the opinion of the investigator would interfere with evaluation of the symptoms and functional limitations that arise from the intermetatarsal neuroma. For example, if the subject has pain from a bunion but that pain is easily distinguished by the subject from the neuroma pain, then the subject would still be a candidate for the study. Note, however, that the subject should also be able to distinguish the neuroma pain from the bunion pain in terms of foot function. In general, if another foot pain condition (in the same foot) gives rise to pain that is greater than the neuroma pain, then that subject should in most instances be excluded. 7. Signs of arterial insufficiency in the feet. 8. Ulcer and/or wound in the foot affected by the neuroma. 9. Active cutaneous disease, or other anatomical or physiological foot disorder, at the anticipated site of study drug injection. 10. History of clearly documented allergic reaction to local anesthetics or capsaicin. 11. Presence of any medical condition or instability that, in the judgment of the Investigator, might adversely impact the conduct of the study or resulting data, including chronic conditions that are likely to alter the rate of healing or are likely to result in safety complications unrelated to the study medication, such as uncontrolled diabetes mellitus or vascular disease. 12. Clinically significant laboratory result at the Screening Visit (in the opinion of the Investigator). 13. Has diabetic neuropathy or other length dependent neuropathy. 14. Use of any investigational medication in the 30 days prior to the current study, is scheduled to receive such an agent while participating in this study, or received a topical or injected investigational medication in the index foot within the past 60 days. 15. Use of topical medication on the index foot within 7 days of screening (including lidocaine or capsaicin). 16. Prior participation in an ALGRX 4975 study. 17. History of substance abuse disorder within the past year as defined by DSM-IV, has current evidence for a substance abuse disorder, is receiving medicinal treatment for drug abuse, or tests positive upon urine drug screen for a substance of abuse. 18. Has any condition or is taking any medication that would be contraindicated for study participation
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Radial Artery Cannulation needing radial arterial cannulation intraoperatively refusal to consent minors incarcerated individuals radial cannulation within past month negative modified Allen's test shock non-English speaking
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Trichomonas Vaginalis Female subjects will be recruited from the general population as they present to the clinical facility. Subjects will be categorized by the clinician as either asymptomatic or symptomatic for Trichomonas vaginalis infection. Symptoms in women can Greenish-yellow, frothy vaginal discharge with a strong odor Painful urination Vaginal itching and irritation Discomfort during intercourse Lower abdominal pain (rare) The study is limited to females. Male subjects are not accepted. 2. At clinical sites informed consent, unable to understand and consent to participation; for minors this includes parent or legal guardian
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Pain Adults > 18 years of age Planning for outpatient surgical treatment of SUI with placement of a transobturator suburethral sling under general anesthesia Pregnant or nursing Allergy to bupivacaine History of drug/alcohol abuse Severe cardiovascular, hepatic, renal disease, or neurological impairment° Long-acting opioid within 3 days or any opioid use within 24 hours before surgery Contraindication to acetaminophen oxycodone non-steroidal anti-inflammatory drugs (NSAID) Administration of an investigational drug within 30 days before study
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Osteoarthritis of the Knee Chronic Lower Back Pain Patient has a primary diagnosis of OA of the index knee with symptoms for at least 6 months prior to screening and patient meets American College of Rheumatology clinical classification for OA of the knee, defined by the following Knee pain and at least 3 of the following 6: 1. Age > 50 years 2. Morning stiffness < 30 minutes 3. Crepitus on active motion 4. Bony tenderness 5. Bony enlargement 6. No palpable warmth of synovium Patient has a radiographic image of the index knee (according to the minimum quality for radiographic image as set by the central radiology reader) showing evidence of OA with a Kellgren-Lawrence grade ≥2 at screening (based on central reading) Patient has moderate to severe index knee pain (pain due to OA of the knee at least 5 days per week for the last 3 months prior to screening, as determined by patient's medical history) Patient is ambulatory and the index knee must not contain any orthopedic and/or prosthetic device WOMAC pain subscale score (with a 48-hour recall period) in the index knee ≥ 4 at baseline (visit 2 predose, mean of all questions on pain subscale) WOMAC physical function subscale score ≥ 4 at baseline (visit 2 predose, mean of all questions on physical function subscale with a 48-hour recall period) Patient is willing to discontinue all current pain medications during the baseline and treatment periods (until day 57) (except for allowed rescue medications). Low dose aspirin for cardioprophylaxis is allowed Patient is compliant with daily pain recording. Compliance with diary completion will be defined as daily average pain ratings on at least 5 days of the baseline period, of which at least 3 days are in the last 4 days prior to visit 2 Male patient and their female spouse/partners who are of childbearing potential must be using a barrier method and 1 form of highly effective birth control starting at screening and continuing throughout the study period and for 90 days after the final study drug administration Medical History / Clinical Status Patient has a history of suicide attempt or suicidal behavior. Suicidal ideation within the last 12 months (a response of "yes" to questions 4 or 5 on the suicidal ideation portion of the Columbia-Suicide Severity Rating Scale [C-SSRS]), or who are at significant risk to commit suicide, as judged by the investigator at screening and at the time of randomization Patient has current or prior psychosis, major depressive disorder or other clinically significant psychiatric disorder Patient has a current or prior clinically significant neurologic disease, including but not limited to peripheral neuropathy, stroke, cognitive impairment and seizure. Childhood febrile seizures are not exclusionary Patient has any clinically significant uncontrolled musculoskeletal disorder (with the exception of OA), cardiovascular, gastrointestinal, endocrinologic (diabetes mellitus is allowed if controlled [glycated hemoglobin (HbA1c) ≤ 8.0%] and no peripheral neuropathy), hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, dermatologic, renal and/or other major disease Patient has an active malignancy or a history of malignancy (except for treated nonmelanoma skin cancer) within the past 5 years Patient has a history of inflammatory arthritis, (including rheumatoid arthritis or a history of RPOA, osteonecrosis or avascular necrosis of bone and/or joints), or has other diagnoses that may increase the risk of RPOA (e.g., pre-existing atrophic OA, subchondral insufficiency fracture), or severe knee malalignment or any other joint-related condition that makes the patient unsuitable for study participation (e.g., joint pain that is disproportionately severe, or which has atypical features for OA pain, should trigger further medical evaluation to rule out subchondral insufficiency fracture) Patient has findings suggestive of RPOA or increased risk for RPOA on screening radiographs of either index or non-index joints (based on central reading) Patient has a history of shoulder surgery, clinically significant trauma or current symptoms, including pain or impaired range of motion at shoulder joint Patient has a coagulopathy, is receiving anticoagulants or has been diagnosed with thrombocytopenia or a functional platelet disorder
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Anorectal Surgeries Elective colo-rectal surgery with or without anastomosis and with or without stoma Patient age: 18-80 Pregnancy Anesthesiology ASA score of 4 or above fever or existing signs of infection at the time of surgery Diabetes Mellitus type I or II with HbA1C level 12% or more Persons with decubitus or diabetic ulcers Subjects with peritoneal metastases Patients with severe malnutrition as indicated by Prealbumin value of <20 BMI ≥50
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Reduction of Negative Appendectomy Rate complete evaluation, examination and diagnostic pathways of the patients with suspected appendicitis in our University Hospital appendectomy during other operations
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-35.0, Infertility More than 9 days of induction of ovulation. 2. Each ovary contains more than 20 follicles. 3. The majority of follicles are >14mm in diameter. 4. Mild fluid in Douglas pouch. 5. The patient started to complain of considerable lower abdominal pains before the egg collection Recurrent ICSI failure or bad obstetric history. 2. Any medical disorder affecting the fluid shift as: diabetes mellitus, autoimmune diseases, hepatic, renal or cardiac conditions
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Therapy, Photodynamic Keratosis, Actinic Pain Patients with symmetrically distributed AKs on the scalp, forehead, cheeks, torso, back, arms and/or dorsal parts of the hands Patients >18 years of age who have signed a written informed consent Pregnant or breast-feeding Participating in other clinical study at the same time or within 30 days Conditions associated with poor protocol compliance, e.g. excessive use of alcohol or drug abuse
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-70.0, Ovarian Cancer Performance Status 0-2 PNN> 1.5.109 / L (without added GCSF) Plaquettes> 100. 109 / L Bilirubine inferior or equal to 1.5 times the upper normal value (VNS) ASAT And ALT inferior or equal to 2.5 upper normal value (VNS) Alkaline Phosphatase inferior or equal to2.5 upper normal value (VNS) Clairance Creatinine> 60ml / min Normal -Ionogramme PTT <1.5 times the upper normal value (VNS) (heparin, or other accepted lovenox anticoagulants) PT / INR inferior or equal to 1.5 upper normal value (VNS) (or INR between 2 and 3, if the patient receives a stabilized dose of Warfarin) Patient operated first line without macroscopic residual for ovarian cancer or primary peritoneal or tubal stage IIIC or IV peritoneal pleural Patient with cognitive and psychiatric disorders Patient deprived of liberty by a court or administrative Patient having directions against the achievement of chemotherapy Concomitant treatment with a drug test, participation in another therapeutic clinical trial within 30 days Pregnant women Nursing women Patient with recognized hypersensitivity to cisplatin or platinum-containing products Patient with hypersensitivity recognized paclitaxel or any of the excipients Patient must be vaccinated against yellow fever Patient before taking phenytoin for prophylactic purposes
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 16.0-99.0, Acute Appendicitis all acute appendicitis patients underwent total laparoscopic appendectomy or laparoscopic assisted appendectomy no written informed consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-40.0, Appendicitis Subjects has pathologically proven appendicitis for appendicitis group Subjects has American Society of Anesthesiologists Physical Status classification 4 Subject has pregnancy Subject has malignity Subject has chronic illness Subjects who won't accept to join the study Subjects who don't have family members
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Appendicitis Abdominal Abscess Acute Disease Cecal Diseases Infection Patients with complicated acute appendiccitis Laparoscopic approach Open approach Medical or psychiatric condition of the patient that compromises the informed consent authorisation Non complicated acute appendicitis Underage patients (<18) Refusal to participate in the study
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 9.0-13.0, Anxiety Abdominal Pain Participants need to meet the for functional abdominal pain as specified by the Rome III: Scenario #1 for 1. In the last 2 months, how often did the child have pain or an uncomfortable feeling in the upper abdomen above the belly button? If ≥ 8 (or if the combination of #1 and #2 is ≥8) 2. In the last 2 months, how often did the child have pain or an uncomfortable feeling in the upper abdomen below the belly button? If ≥ 8 (or if the combination of #1 and #2 is ≥8) Scenario #2 for 3. In the last 2 months, when the child hurt or felt uncomfortable above (below) the belly button, how often did your child miss school or stop activities? If #1 and #2 is ≥ 2 (or if the combination of #1 and #2 is ≥2) and #3 is ≥ 25% of the time. They also have to be at or above cutoff (i.e. TS>= 55) for Beck Youth Inventory (BYI) which can be determined by finding the corresponding raw score, gender, and age on Appendix A in the BYI manual Participants with immune disorders will be automatically excluded from this study
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-64.0, Surgery Patients between the age of 18-64; BMI greater than 18.5 Abdominal hernias
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Acute Appendicitis RLQ pain with clinical suspicion for acute appendicitis History of appendectomy Imaging prior to ED ultrasound performed to evaluate the RLQ Patients who are decisionally impaired or cannot provide consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Appendicitis Clinical suspicion of acute appendicitis Equivocal appendicitis defined by Adult Appendicitis Score: Score ≥11 and ≤15 C-reactive protein >99 mg/l Time from symptom onset over 24 hours Pregnancy Antibiotics given within last 24 hours Suspicion of other disease than appendicitis, that would require immediate interventions such as surgery, diagnostic imaging or gynecologic consultation Missing written informed consent Patient randomized earlier to the study
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-40.0, Caesarean Section single fetus more than 37 weeks of gestation elective Caesarean section non-cephalic presentation placenta previa hydrocephalus Multiple pregnancy
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 21.0-999.0, Endoscopy Referred for clinically indicated gastrointestinal diagnostic endoscopy Ability to understand the requirements of the study, to provide written informed consent and to comply with the study protocol Ability to understand and provide written authorization for the use and disclosure of protected health information (PHI) per the Health Insurance Portability and Accountability Act (HIPAA) privacy ruling Under the age of 21 years Is an inmate (see US Code of Federal Regulations 45 C.F.R. 46.306)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Irritable Bowel Syndrome With Diarrhea Male and female patients age≥18 years (with a minimum of 35% males in the study) 2. Patient meets FDA guidance and Rome III for IBS-D: a. Recurrent abdominal pain or discomfort over ≥6 months, with frequency ≥3 days/month in the last 3 months associated with ≥2 of the following: i. Improvement with defecation ii. Onset associated with a change in frequency of stool iii. Onset associated with a change in the form of stool b. Loose or watery stools (Bristol stool form scale 6 or 7) ≥2 days per week 3. Average worst daily pain intensity ≥3.0 for each of the two baseline weeks 4. Major laboratory parameters within the following limits (no worse than grade 1 abnormalities per NCI-CTCAE v4): a. Adequate hematologic function, as demonstrated by i. Hemoglobin ≥10 g/dL ii. Absolute neutrophil count (ANC) 1.5-10 x 10^9/L iii. Platelets ≥100 x 10^9/L b. Adequate liver and renal function as demonstrated by i. Aspartate transaminase (AST) and Alanine transaminase (ALT) each ≤ 3.0 x upper limit of normal (ULN) ii. Total bilirubin ≤1.5 x ULN iii. Creatinine ≤1.5 X ULN c. Euthyroid based on thyroid-stimulating hormone (TSH) and free T4 levels 5. Patients on thyroid hormone replacement must be on a stable dose for at least one month prior to study entry. 6. C-reactive protein ≤2 x ULN for lab 7. Patients of childbearing potential and male patients with partners of childbearing potential must utilize effective contraceptive measures Women of childbearing potential are women who have menstruated in the past 12 months, with the exception of women who have undergone surgical sterilization 8. All patients must sign informed consent Evidence of other cause for bowel disease: 1. Relevant abnormalities seen on colonoscopy if previously performed or if required per this protocol. These but are not limited to Crohn's disease, ulcerative colitis, diverticulitis, ischemic colitis, microscopic colitis. 2. History of and/or positive serologic test for celiac disease 3. Known or suspected lactose intolerance. 2. History of abdominal surgery other than appendectomy or cholecystectomy at any time 3. Any elective major surgery (of any organ) planned for the period of the study, including follow-up 4. History of organic abnormalities of the GI tract including but not limited to intestinal obstruction, stricture, toxic megacolon, GI perforation, fecal impaction, gastric banding, adhesions or impaired intestinal circulation (e.g., aortoiliac disease) 5. Current or previous diagnosis of neoplasia (except non-GI neoplasia in complete remission ≥5 years, squamous and basal cell carcinomas). With approval of the medical monitor patients with curatively treated neoplasm in complete remission <5 years may be entered in the study. 6. Patients with a history of positive tests for ova or parasites or Clostridium difficile must be retested during the screening period and tests for the relevant agents must be negative 7. Use of any 5-HT3 antagonist (5hydroxytryptamine receptor antagonists) within 4 weeks of the start of baseline data collection. 8. Use of rifaximin within 4 months of the start of baseline data collection. 9. Use of any other agent specific for IBS (such as alosetron or eluxadoline) or for symptomatic treatment of IBS (such as antispasmotics and antidiarrheals other than loperamide) within 2 weeks of the start of baseline data collection. 10. Uses of any investigational agent for any indication within 4 weeks of the start of baseline data collection. 11. Congestive heart failure, bradyarrhythmia (baseline pulse<55/min), known long QT syndrome 12. Patients who have Corrected QT interval (QTc) prolongation>450 msec noted on screening ECG, or who are taking medication known to cause QT prolongation Note: For current list of medications known to cause QT prolongation see: https://www.crediblemeds.org/healthcare-providers/drug-list/ There are several risk categories. Use the list showing those drugs known to cause torsade de pointes (TdP) 13. Hypersensitivity or other known intolerance to ondansetron or other 5-HT3 antagonists 14. Patient has taken apomorphine within 24 hours of screening 15. Pregnant or lactating 16. Patients with other major illnesses, either physical or psychiatric, or social situations which may interfere with participation in the study or interpretation of results 17. Patients with severe hepatic impairment, defined as Child-Pugh score ≥10 at baseline
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Low Back Pain, Mechanical Spinal Stenosis Nerve Root Disorder Radiculopathy, Cervical Benign Hypermobility Syndrome Clinical diagnosis of axial back pain (neck, mid-back, lower back) or pain radiating to the extremity, with suspected diagnosis of a specific pain generator amenable to a pain procedure, including disorders of the nerves, joints, and muscles as listed immediately below Clinical decision to schedule patient for a pain procedure, including procedures targeting the following disorders Facet arthropathy: intra-articular facet joint injection, medial branch block, medial branch radiofrequency ablation Sacroiliac joint dysfunction: sacroiliac joint injection, lateral branch block, lateral branch radiofrequency ablation Myofascial pain syndrome: trigger point injection Radiculopathy, spinal stenosis, or herniated nucleus pulposus: epidural steroid injection, selective nerve root block Piriformis syndrome: piriformis injection Greater trochanteric bursitis: greater trochanteric bursa injection Able to provide HIPAA authorization to share prior medical records/imaging Previous diagnosis of cancer Currently pregnant Previously enrolled for the same procedure or the same pain generator site. (For example, this would a patient who had an intra-articular facet joint injection at the right L5/S1 if: 1) he had the same injection 3 months ago and was enrolled at that time, or 2) the patient was already enrolled for a medial branch block at the right L5 and sacral ala, as this targets the same facet joint.) Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Surgical Site Infection Wound Infection Postoperative Pain Local Anesthetics Patients who are planned to a elective gastrointestinal surgery Biliary-pancreatic open procedures: biliodigestive Derivation, Pancreatoduodenectomy, Pancreato-jejunostomy (Puestow procedure, Frey) Open upper gastrointestinal procedures: total gastrectomy, subtotal gastrectomy (distal gastrectomy with Billroth I reconstruction or Billroth II or Roux-Y), Gastro-jejunum anastomosis, Open gastro-jejunal Roux Y bypass, intestinal resection, intestinal reconnection, intestinal Fistulectomy Open colorectal procedures: Right or Left Hemicolectomy, total colectomy, low anterior resection, abdominal-perineal resection Patients who decide signing the informed consent after explained the study Patients with postoperative follow-up of at least 30 days, in whom the wound and / or local complications will be evaluated Patients operated laparoscopically Patients operated at another hospital Patients with clean surgical wounds Patients in whom an epidural or subarachnoid block is used Patients who are unable to sign the informed consent Patients with less than 50 kg Patients wiht history of: Malignant hyperthermia, cardiac disease (Heart failure, history of myocardial infarction, arrhythmias), Epilepsy, Allergic to amides Patients with incomplete follow-up (less than 30 days) Pregnant patients
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 12.0-75.0, Acute Appendicitis patients with Alvarado scores ≥7 (with or without US/CT) diagnosed of uncomplicated acute appendicitis patients with Alvarado scores <7 but US/CT suggested uncomplicated acute appendicitis or could not acute appendicitis perforated appendicitis periappendiceal abscess contraindications for colonoscopy allergy to contrast media or iodine pregnancy unable to cooperate or provide informed consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Appendicitis Adult ≥18 years; 2. Clinical diagnosis of acute uncomplicated appendicitis (AUA) established by clinical care team, supported by any of the following usual care radiological tests (computed tomography (CT), ultrasound (US), and/or magnetic resonance imaging (MRI)). AUA is defined by the usual signs, symptoms, and imaging finding of appendicitis without: 1. Diffuse peritonitis on clinical exam (i.e., rigid abdomen / four quadrant peritonitis); 2. Radiologic findings of : i. Free air; ii. Walled off fluid collection concerning for an abscess; iii. Significant amounts of intra-abdominal fluid throughout abdomen (i.e., more than trace fluid); or iv. Extent of inflammation or adjacent organ involvement on radiologic imaging such that appendectomy is relatively contraindicated. 3. Ability to provide written or electronic informed consent in English or Spanish 1. Unable or unwilling to return or be contacted for clinical follow-up visits and/or research surveys; 2. Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening; 3. Evidence of severe sepsis or septic shock (e.g., new presumed sepsis-related organ dysfunction, elevated lactate, and/or fluid unresponsive hypotension); 4. Conditions with altered immune response or at risk for bacterial seeding; 5. Immunodeficiency (e.g., absolute neutrophil count <500/mm3, chronic immunosuppressive drugs, active chemotherapy or plans for chemotherapy in the following 30 days, or known acquired immune deficiency syndrome (AIDS) [cluster of differentiation 4 (CD4) count <200 or AIDS-defining illness within the last year] assessed by patient history); 6. Uncompensated liver failure; 7. Taking medication to treat active inflammatory bowel disease (e.g., Crohn's, ulcerative colitis); 8. Malignancy, not in remission (ongoing chemotherapy patients excluded); 9. Pregnant or expectation of becoming pregnant in the 30 days following baseline/screening; 10. Expected concurrent hemodialysis, peritoneal dialysis, or treatments using indwelling venous catheters; 11. Recent (within 90 days) placement of surgical implant (e.g., pacemaker, joint prosthesis, mechanical valve); 12. Indwelling Left Ventricular Assist Device (LVAD); 13. Patients with another infection (e.g., pneumonia, urinary tract infection) that requires treatment with another antibiotic at baseline/screening; 14. Concurrent illness that would otherwise mandate hospitalization outside of appendicitis and associated symptoms at baseline/screening; 15. Imaging findings of any of the following: 1. Appendiceal soft-tissue mass; 2. Imaging features of mucocele or tumor (e.g., appendix measuring ≥ 15mm in diameter and no other CT evidence of appendicitis); 3. Concern for carcinomatosis on imaging; or 16. Severe allergy or reaction (e.g., immediate urticaria or anaphylaxis) to all of the proposed antibiotics; 17. Prior enrollment in the study or other investigational drug or vaccine while on study treatment; 18. Abdominal/pelvic surgery in the past month; or 19. More than seven hours have transpired since the patient received the first parenteral dose of antibiotics
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 30.0-999.0, Breast Diseases Mastodynia Anxiety women over the age of 30 primary focal breast pain, i.e. pain localizable by the patient to within one breast quadrant without other associated symptoms diffuse, radiating, or axillary pain associated palpable findings at the site of pain skin changes (erythema, thickening) nipple changes (discharge, retraction) currently pregnant or breast-feeding history of recent trauma or infection of the affected breast history of ipsilateral breast cancer will be excluded
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 15.0-999.0, Pain Male or female outpatients aged >=15 years at the time of giving consent Patients diagnosed with low back pain, scapulohumeral periarthritis, or cervico-omo-brachial syndrome prior to giving consent. Patients with cervico-omo-brachial syndrome must have the associated symptom of occipital pain No medical therapy for the target disease (low back pain, scapulohumeral periarthritis, or cervico-omo-brachial syndrome) for more than one week prior to Visit 1 (start day of treatment) Patients who meet following with examination conducted before the start of treatment at Visit 1(start day of treatment) Based on patient interview, the evaluation site (low back, shoulder or neck) decided by investigator and visual analogue scales score of >=40 mm (in case there are some evaluation sites, investigators determine its evaluation sites to one site with the biggest of visual analogue scale score Visual analogue scales score of >=40 mm in one of pain symptoms (tenderness, listlessness, pain at rest, pain on motion, night-time pain, or limitation of motion) prior to the start of treatment Muscle strain at the evaluation site (low back, shoulder or neck) has been diagnosed by the Investigator based on patient interview and palpation Patients with pain symptoms at Visit 1 (start day of treatment) who are, in the Investigator's opinion, suitable for treatment with NSAIDs and muscle relaxants Signed and dated written informed consent in accordance with Good Clinical Practice and local legislation prior to admission to the trial. For minors (aged >=15 to <20 years), written informed consent must also be obtained from their legal representative Bronchial asthma at the time of giving consent For patients with allergic rhinitis or atopic disease, the absence of bronchial asthma must be confirmed and documented in the source data Treatment for oesophageal, gastric or duodenal ulcer or erosion within 4 weeks prior to giving consent At Visit 1 (start day of treatment), patients with symptoms at the evaluation site due to injury, tumour, infection or rheumatoid arthritis, or those with obvious neurological (radicular) symptoms (e.g., hernia, etc.) or who may require surgery during the trial period At Visit 1 (start day of treatment), cervical sprain (whiplash) Patients who must carry out hazardous works such as working at high places or driving a car during the trial or those who are, in the Investigator's opinion, difficult to comply with the protocol Patients with cervico-omo-brachial syndrome whose headache is clearly different from the associated symptom of occipital pain or is indistinguishable from occipital pain Patients on therapy for the target disease of this trial (low back pain, scapulohumeral periarthritis, or cervico-omo-brachial syndrome) at the time of giving consent or those having a plan to start a new therapy in the future. The therapy includes medical therapy, physical therapy and rehabilitation Using corticosteroids (oral, injection or suppository or topical use for pain relief) within 4 weeks prior to Visit 1 (start day of treatment) - The use of inhaled corticosteroids for asthma and chronic obstructive pulmonary disease is allowed Patients who must use the prohibited medications or treatments during the trial period
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 7.0-17.0, Appendicitis Age 7-17 years Radiologically confirmed simple appendicitis, defined as: 1. Clinical findings Unwell, but not generally ill Localized tenderness in the right iliac fossa region Normal/hyperactive bowel sounds No guarding No mass palpable 2. Ultrasonography Incompressible appendix with an outer diameter of ≥6 mm Hyperaemia within the appendiceal wall Without faecolith Generalized peritonitis, complex appendicitis or sepsis (based upon predefined and scoring system) Scoring system: As scoring system was developed determining the risk of complex appendicitis based upon five pre-operative variable. Points have been awarded to each variable. In case the total score is less than 4 points, the patient is likely to have a simple appendicitis. In case the score is 4 or more points, the chance of having complex appendicitis is significant and those children will be excluded from this study. Variables Diffuse abdominal guarding (3 points) C-Reactive Protein level more than 38 mg/L (2 points) Signs on ultrasound indicative of complex appendicitis (2 points) More than one day abdominal pain (2 points) Temperature: more than 37.5 degree Celsius (1 point) Faecolith (ultrasound) Serious co-morbidity Recurrent appendicitis
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 15.0-60.0, Acute Appendicitis acute appendicitis Pregnant women and patients with severe medical disease (hemodynamic instability, chronic medical or psychiatric illness, cirrhosis, coagulation disorders) requiring intensive care
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-75.0, Chronic Pain Adults age 18-75 2. Patients able to self-report their pain using a validated pain scale 3. Patients of the chronic pain clinic who will be receiving a pain treatment procedure 4. English speaking 5. Received and signed a consent to participate in the study Pregnant and lactating women 2. Patient with chronic malignant pain 3. Patients less than 18 4. Patient older than 75 5. Patients with dementia 6. Non-English speaking patients 7. Patients unable to do a self-report pain scale 8. Uncontrolled psychiatric conditions 9. Uncontrolled substance abuse issues 10. Patient's lost to follow-up 11. Patients who don't wish to participate
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Appendicitis Right iliac fossa pain t episode in the past 1 year Raised WCC or CRP Fluent in English History of inflammatory bowel disease or appendectomy B-HCG positive Significant co-morbidities Complicated appendicitis as proven by ultrasound, CT or MRI Anaphylaxis to penicillin
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Appendicitis Patient with accute appendicits Patient younger than 18 years
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-75.0, Colon Cancer Age ≥ 18 and ≤ 75 years; 2. Primary tumor has undergone histologically confirmed right-sided colon adenocarcinoma; 3. Together with clinical or radiological evidence of Stage(T1-2,N0, M0) Stage II (T3-4, N0, M0) or Stage III (T1-4, N1-2, M0) disease (according to the 2007 revision of the International Union Against Cancer TNM staging system) 4. Performance status (ECOG) 0~1 5. Adequate hematological function: Neutrophils≥1.5 x109/l and platelet count≥100 x109/l; Hb ≥9g/dl (within 1 week prior to randomization) 6. Adequate hepatic and renal function: Serum bilirubin≤1.5 x upper limit of normal (ULN), alkaline phosphatase ≤5x ULN, and serum transaminase (either AST or ALT) ≤ 5 x ULN(within 1 week prior to randomization); 7. Written informed consent for participation in the trial Other previous malignancy within 5 years, with exception of a history of a previous basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix 2. Pregnancy (absence confirmed by serum/urine β-HCG) or breast-feeding 3. Known drug abuse/ alcohol abuse 4. Legal incapacity or limited legal capacity 5. Pre-existing peripheral neuropathy
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Diverticulitis Acute abdominal pain Signs of localized or diffuse peritonitis Signs of suspected perforated diverticulitis (diagnostic imaging) Signed informed consent Septic shock Immunodepression Previous multiple abdominal surgical operations Modified Hinchey's grade IV
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Periappendicular Abscess Age 18-60 years or MRI-diagnosed periappendicular abscess, that has initially undergone successful conservative treatment with antibiotic therapy and drainage, if necessary Suspicion of a tumour on CT or MRI Age under 18 years or over 60 years Pregnancy or lactating Allergy to contrast media or iodine Renal insufficiency Metformin medication (DM) Unsuccessful initial conservative treatment of periappendicular abscess Lack of co-operation (unable to give consent) A severe medical condition Previous acute appendicitis treated conservatively with antibiotics
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Inflammatory Back Pain To diagnose IBP the standard Berlin will be adopted. IBP is defined by at least 2 positive responses among four items morning stiffness >30 min of duration improvement in back pain with exercise but not with rest awakening because of back pain during the second half of the night only alternating buttock pain. To diagnose CD the standard will be adopted. All the patients will meet the following positive serum anti-transglutaminase (anti-tTG) and anti-endomysium (EmA) immunoglobulin (Ig)A and IgG antibodies presence of intestinal villous atrophy. To diagnose NCWS the recently proposed will be adopted. All the patients will meet the following negative serum anti-transglutaminase (anti-tTG) and anti-endomysium (EmA) immunoglobulin (Ig)A and IgG antibodies absence of intestinal villous atrophy negative IgE-mediated immune-allergy tests to wheat (skin prick tests and/or serum specific IgE detection) for NCWS diagnosis will be positive EmA in the culture medium of the duodenal biopsies, also in the case of normal villi/crypts ratio in the duodenal mucosa self-exclusion of wheat from the diet and refusal to reintroduce it before entering the study other previously diagnosed gastrointestinal disorders other previously diagnosed rheumatic diseases nervous system disease and/or major psychiatric disorder physical impairment limiting physical activity
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Pulmonary TB Diagnoses Diseases Symptoms suggesting pulmonary TB, i.e. persistent cough (generally > 3 weeks or as per local definition of TB suspect) and at least one other finding listed below: 1. Persistent cough 2. Fever 3. Malaise 4. Recent weight loss 5. Night sweats 6. Contact w/ active case 7. Hemoptysis 8. Chest pain 9. Loss of appetite 10. Other [specify] Provision of informed consent to sample collection, banking and HIV and breath-based assay testing Production of adequate quantity of sputum (sputum induction whenever possible) Adult age (>18 years old) Participants receiving any anti-tuberculosis medication, including fluoroquinolone and aminoglycosides in the 60 days prior to enrolment Participants with ONLY extra-pulmonary disease will be excluded Participants for whom complete follow-up and a clear final diagnosis are judged to be difficult (e.g. residents elsewhere or about to move)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-70.0, Prostatitis Chronic Prostatitis Interstitial Cystitis Painful Bladder Syndrome Bladder Pain Syndrome Consent: Participant has signed and dated the Informed Consent document, approved by the Johns Hopkins Medical Institutions Institutional Review Board Agreement: Participant agrees to participate in study procedures Age: Participant is at least 18 years of age Symptom Severity: Participant reports a response of at least 8 on the Pain Domain of the NIH-Chronic Prostatitis Symptom Index (CPSI) Questionnaire Duration of Symptoms: Symptoms have been present for at least 3 months within the preceding 6 months Urethral conditions: Participant has an ongoing symptomatic urethral stricture Bladder conditions: Participant has a history of cystitis caused by tuberculosis, radiation therapy or cytoxan/cyclophosphamide therapy, augmentation cystoplasty or cystectomy Testicular conditions: Participant diagnosed with unilateral orchialgia, without pelvic symptoms Prostate conditions or procedures: Participant has a history of transurethral microwave thermotherapy (TUMT), transurethral needle ablation (TUNA), balloon dilation, prostate cryosurgery, or laser procedure Neurological diseases or disorders affecting the bladder: Parkinson disease, multiple system atrophy, multiple sclerosis, spinal cord injury, cervical myelopathy, acute transverse myelitis, diabetic cystopathy, or dysfunctional voiding (non-neurogenic neurogenic bladder or Hinman syndrome) Psychiatric conditions: Participant has current major psychiatric disorder or other psychiatric or medical issues that would interfere with study participation (e.g. dementia, psychosis, upcoming major surgery, etc.) Malignancy: Participant has a history of cancer (with the exception of skin cancer). Control group In addition to the listed above, additional for control subjects are as follows Chronic Pain: In the past year, symptoms of discomfort or pain in the pelvic region for a period longer than 3 months within the preceding year
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Acute Pancreatitis The patients were classified into the group of patients with acute pancreatitis (AP) due to clinical symptoms (acute onset of a persistent, severe, epigastric pain with tenderness on palpation on physical examination), personal interview and clinical method used in the diagnosis of pancreatitis laboratory tests (elevation in serum lipase or amylase to three times or greater than the upper limit of normal) and characteristic findings of acute pancreatitis on imaging (contrast-enhanced computed tomography (CT), magnetic resonance imaging (MRI) or transabdominal ultrasonography). In patients with characteristic abdominal pain and elevation in serum lipase or amylase to three times or greater than the upper limit of normal, no imaging was required to establish the diagnosis of acute pancreatitis. In patients with abdominal pain that was not characteristic for acute pancreatitis or serum amylase or lipase levels that were less than three times the upper limit of normal, or in whom the diagnosis was uncertain, the investigators performed abdominal imaging with a contrast-enhanced abdominal CT scan to establish the diagnosis of acute pancreatitis and to other causes of acute abdominal pain. In patients with severe contrast allergy or renal failure, the investigators performed an abdominal MRI without gadolinium The volunteers classified as healthy based on the research conducted by clinicians of primary medical care (control group) other accompanied diseases than acute pancreatitis (the patients groups) Individuals of the control group with diagnosed disease as well as alcohol and drugs abusers
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Colon Cancer Anastomosis Patient diagnosed with a solitary benign or malignant neoplasm localized in the right colon Patients aged 18 years or older Patients who give written informed consent acute intestinal obstruction colon perforation liver and/or lung metastases multiple primary colonic tumors scheduled need for synchronous intra-abdominal surgery preoperative evidence of invasion of adjacent structures, as assessed by CT or ultrasonography previous ipsilateral colon surgery
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Lumbopelvic Postpartum Pain Primparous women Postpartum, between 8-12 weeks after the date of delivery With lumbopelvic pain and positive diagnostic tests of sacroiliac pain Women with ambulation ability Presence of vaginal prolapses Be receiving another treatment for the alteration that concerns us, pharmacological or any other type of therapy Neuromuscular alterations
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-45.0, Anesthesia,Obstetrical • Patients between the ages of 18 and 45 presenting for a C-section delivery or scheduled for elective Cesarean section ASA-1, ASA-2, and ASA-3 Patients with no known back deformities Ability to sit upright for spinal placement No prior lumbar surgery No allergies to ultrasound gel • Unable or unwilling to give informed consent
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-90.0, Anesthesia, Local patients, referred for elective diagnostic coronary angiography acute coronary syndrome previous ipsilateral transradial approach Raynaud's syndrome abnormal renal function with or without need for hemodialysis known history of sensitivity to local anesthetics non-palpable radial pulse, abnormal Barbeau's test patient's refusal
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Chronic Low Back Pain primary complaint of chronic non-specific low back pain (more than 12 weeks) pain symptoms in the low back with a score ≥ 2/10 on the 0-10 Numerical Pain Rating Scale (12) aged 18-80 history of surgery in the abdominopelvic region for more than 6 months history of visceral dysfunction (e.g., constipation and reflux); and no known or suspected serious spinal pathology (e.g., metastasis, inflammatory or infective diseases of the spine, causa equine syndrome, canal stenosis, spinal fracture) no nerve root compromise evidenced by at least two of the following: (1) myotomal weakness, (2) dermatomal or widespread sensory loss, (3) hyporeflexia or hyperreflexia of the lower limb reflexes no spinal surgery within the preceding 6 months no vascular abnormality such as abdominal aortic aneurysms not currently receiving chiropractic, osteopathic or other physical therapy not pregnant or suspect being pregnant not currently in an acute inflammatory phase of known gastrointestinal or urinary diseases (such as cholecystitis, renal calculi, peritonitis, appendicitis) not currently taking medications that significantly alter gut motility not currently taking medications (such as oral corticosteroids) which are known to increase the risk of intestinal perforation) no known gastrointestinal disease that associates with a risk of intestinal perforation (e.g. Chron's disease, diverticular disease, peptic ulcer disease) not taking anti-platelet medications such as warfarin
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-15.0, Appendicitis Acute appendicitis was diagnosed in accordance with following clinical, laboratory, and radiographic criteria; history of right lower quadrant pain or periumbilical pain migrating to the right lower quadrant with nausea and/or vomiting. presence direct and indirect tenderness on McBurney's point and/or right lower quadrant guarding. a fever ≥ 38°C and/or white blood cell counts more than 10X10³ cells per mL on complete blood count. diameter of appendix ≥ 6 mm with mural thickening and periappendiceal fat infiltration and/or abdominal fluid collection on appendiceal ultrasonography or abdominopelvic computed tomography Perforated appendicitis: disrupted appendix contour with non-homogenous peritoneal fluid collection in pelvic cavity and/or sub-hepatic space simultaneously with above mentioned clinical, laboratory, and radiographic findings of appendicitis Peri-appendiceal abscess which was preoperatively confirmed by ultrasonographic and/or computed tomographic evidence Suspicious diagnosis of appendicitis which was not in accordance with the diagnosis criteria Patients who were subjected to ≥ 2 days of empirical antibiotics therapy for initial symptom prior to diagnosis with acute appendicitis History of coagulation disorders, shock upon admission, previous abdominal surgery, contraindication to general anesthesia, suspected or proven malignancy, and mental illness
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-999.0, Pain over 20 year old cancer pain with visual analog scale or numeric rating scale score >/ opioids candidates with informed consent form life expectancy within 3 months
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-35.0, Primary Dysmenorrhea must be nullipara patients with symptoms of severe primary dysmenorrhea The characteristic of pain must be periodic (at least following 3 menstrual cycles) midline lower abdominal cramps or pelvic colic like pain that starts up to one day before menses lasts for the 3 days of bleeding gradually diminishes over 12 to 72 hours ends after period The pain must start generally in 2 to 3 years after menarche with regular menses (25-31 day) Patients with history of pelvic inflammatory diseases endometriosis ovarian cysts chronic abdominal pain fibroids obstructive endometrial polyps cervical stenosis inflammatory bowel syndrome irritable bowel syndrome major abdominal or pelvic surgery
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Injection Site Arthritis;Hand/Finger(S) The patient has clinical signs of trapeziometacarpal arthritis and are willing to obtain a post injection x-ray The patient is over the age of 18 years of age The patient has a known allergy to contrast dye The patient has a planned surgery on the trapeziometacarpal joint within 6 weeks following injection Patients who are pregnant or believe they may be pregnant Prisoners Patients who are unable to provide informed consent
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 5.0-17.0, Appendicitis Perforated Appendicitis Ruptured Appendicitis Complicated Appendicitis At least 1 of the following CT or MRI findings: 1. Peri-appendicular abscess 2. Extruded appendicolith 3. Visible hole in appendiceal wall 4. Free peritoneal air OR 2. CT or MRI read with phlegmon or diffuse/extensive inflammation/free fluid plus 1 of 3 of the following (with CT) or 2 of 3 of the following (with MRI) *: 1. White blood cell count (WBC) >15 2. Peritonitis (involuntary right lower quadrant (RLQ) guarding, + Rovsing sign, percussion tenderness, and/or rebound tenderness) 3. Temperature > 38.0 C *>90% specificity for complicated appendicitis based on unpublished institutional data Immunocompromized state 2. History of major abdominal operation 3. Previous appendicitis 4. Major comorbidities that preclude safe operation 5. Inability to follow-up or appropriately consent 6. Pregnant women 7. Allergy to penicillin plus any one of the following: 1. Hypersensitivity to ciprofloxacin and/or metronidazole 2. Pregnant/lactating women 3. Patients taking theophylline 4. Patient taking tizanidine
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-80.0, Plantar Fasciitis (Sub-project 1) Patients with PHP Age between 20 years History of PHP for at least 1 month before enrollment Pain or tenderness on palpation of the medial calcaneal tubercle or the proximal plantar fascia Occurring at least one of the following complaints: pain on the first step in morning or after prolonged sitting, pain on prolonged standing, or pain when running Thickness of the plantar fascia of 4.0 mm or greater assessing by US diagnosis Healthy No past or present history of PHP or foot pain Any coexisting painful musculoskeletal conditions of lower extremity; achilles or tibialis posterior tendinopathy, acute ankle sprain, tarsal tunnel syndrome, heel pad syndrome Any fracture or surgery history in lower extremity and foot within 6 months Lumbar radiculopathy or central or peripheral neuropathy Systemic arthritis such as rheumatoid arthritis Neurological or vascular compromise of the foot related to diabetes Have a history of steroid injection within 6 months Leg length discrepancy more than 1 centimeter Currently taking pain medication (Sub-project 3) Age between 20 years
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-50.0, Pelvic Congestive Syndrome Clinical symptoms of pelvic congestion syndrome documented by Doppler ultrasound Failed medical treatment Endometriosis Uterine fibroids Previous pelvic operations Urological diseases
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 13.0-999.0, Appendicitis Surgery More than 12 years of age High probability of early-uncomplicated acute appendicitis with confirmed score of 7.5 to 11.5 years of age or less score 7 or less, or greater than 12 Clinical diagnosis of acute complicated appendicitis with perforation or signs of generalized peritonitis
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-999.0, Acute Pancreatitis Patients diagnosed with acute pancreatitis The definition of acute pancreatitis is based on the fulfillment of 2 out of 3 of the following clinical (upper abdominal pain), laboratory (serum amylase or lipase > 3 x upper limit of normal) and/or imaging (computed tomography, magnetic resonance imaging, ultrasonography) criteria Those whose informed consent could not be obtained Patients with severe pancreatitis accompanying multiple organ failure
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-70.0, Surgical View Shoulder Tip Pain Abdominal Pain Age 18-70 years Ability to give informed consent Patients who are approved by the anaesthetics to undergo bariatric surgery Age below 18 and above 70 Inability to give informed consent Patient unfit for bariatric surgery including who has poor respiratory, cardiac, renal and liver function Patient with Body Mass Index (BMI) >50 Patient with American Society of Anesthesiologists (ASA) >3
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-999.0, Acute Appendicitis The patients admitted to the NTUH Yunlin branch diagnosed clinically as acute appendicitis 2. The patients with clinically suspected right lower quadrant pain and acute appendicitis could not be excluded Not eligible to underwent laparoscopic surgery because of compromised cardiopulmonary function or major laparotomy surgery 2. Decide to receive non-surgical treatment of the acute appendicitis 3. Age<20, or could not exercise the right of autonomy or unwilling to participate the study
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Fibromyalgia Depression Being 18 years old or older 2. Understanding Spanish 3. Meeting the diagnostic for fibromyalgia according to the Fibromyalgia Survey Questionnaire (FSQ) 4. Have a primary diagnosis of major depression according to the MINI International Neuropsychiatric Interview (MINI). 5. Being receiving usual care for fibromyalgia and depression in the Medical Center San Joaquín (Red Salud UC Christus, Santiago Chile). 6. Being under treatment with duloxetine Having past or present history of psychosis, bipolar disorder, or substance use disorder 2. Presenting risk of suicide according to the suicide module of the MINI 3. Presenting a lower score than the cut-off point in the Minimental Cognitive Examination 4. Being participating simultaneously in another therapy for the depression or pain 5. Being treated with antidepressants other than duloxetine 6. Being diagnosed with Rheumatoid arthritis or other connective tissue diseases
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Small Intestinal Bacterial Overgrowth Small Intestinal Fungal Overgrowth Colectomy patients who were referred to a specialist motility center over 4 year period with Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort history of colectomy patients with no history of colectomy patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan patients with glucose breath test and/or duodenal aspirate patients with upper gut or small bowel surgery Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Irritable Bowel Syndrome With Diarrhea Males and females 18 years of older Meet the Rome IV for IBS (abdominal pain or discomfort at least 3 days per month in the last three months associated with two or more of the following: defecation, onset associated with change of frequency of stool or change associated with a change in form of stool. The symptoms must be going on for more than six months and be associated with an absence of routine clinical red flags) Patients with a history of gastric, small bowel or colonic surgery Patients with active Inflammatory Bowel Disease Patients with celiac disease Patients who are unable or unwilling to come off the following medications: antibiotics, stool bulking agents, narcotics, or lactulose Patients who are already on a low-FODMAP diet or a diet that may be have substantially different content from usual Canadian diet (paleolithic diet, specific carbohydrate diet, gluten-free diet, Atkins) Patients cannot have used antibiotics in the past 4 weeks Pregnant patients will not be invited to participate. (Sexually active women of child-bearing age will be asked if it is possible that they are pregnant, and if there is a doubt, they will not be invited to participate.) Patients will confirm they are using birth control during the time they are participating in the study
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Acute Appendicitis Age between 18-60 years CT confirmed uncomplicated acute appendicitis Ability to give informed consent Age under 18 or over 60 years Pregnancy or lactation Allergy to contrast media or iodine Allergy or contraindication to antibiotic therapy Metformin medication Renal insufficiency Severe systemic illness (for example malignancy, medical condition requiring immunosuppressant medication) Complicated acute appendicitis confirmed by CT scan Inability to cooperate or give informed consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Acute Appendicitis Age 18-60 years CT confirmed uncomplicated acute appendicitis Ability to give consent to participate in the study Age under 18 years or over 60 years Pregnancy or lactation Allergy to contrast media or iodine Allergy or contraindication to antibiotic therapy Renal insufficiency Metformin medication Severe systemic illness (for example malignancy, medical condition requiring immunosuppressant medication) CT confirmed complicated acute appendicitis Inability to co-operate and give informed consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Pain, Chronic Opioid Use Age 18-65 2. With and without history of chronic muscle-skeletal pain * 3. Scheduled to undergo elective abdominal surgery requiring overnight hospital admission 4. Opioid naïve** 5. Willing to comply with study procedures as outlined in the protocol 6. Willing and able to provide informed consent 7. Having an email address and access to a computer or electronic tablet Current use of opioids (includes ANY use in past 3 months) 2. Cancer diagnosis 3. Patient presenting the following documented conditions: Untreated psychosis Current suicidal ideation Current substance abuse
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Perforated Appendicitis Clinical diagnosis of acute perforated appendicitis fit for laparoscopy and general anesthesia written informed consent short term outcome data and agree to provide contact information high risk for general anesthesia Appendicular abscess and appendicular mass ongoing infections including chest infections Children and pregnant females
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-40.0, Acute Abdominal Pain Pelvic Pain Women aged 18-40 years old Women referred to CT following a non contributive ultrasonography Women with acute non traumatic abdominopelvic pain (less than 5 day-duration) Women with informed consent Women with affiliation to health insurance Women who underwent abdominopelvic surgery in the previous month Suspicion of vital emergency such as shock preventing any delayed management caused by MRI examination Contra-indication to MRI, including pace maker, ferro-magnetic material, foreign bodies with risk of mobilization during MRI examination Women yet included in the study Women pregnant (positive beta chorionic gonadotrophic hormone testing) or breastfeeding Women unable to undergo informed consent (vulnerable or protected by law)
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-35.0, Patellofemoral Pain Syndrome Presence of localized pain in the anterior region of the knee and / or around the patella, reproduced with at least two of the following activities: climbing / descending stairs, crouching, kneeling, long sitting, isometric contraction of the quadriceps, running and jump Existence of a report of pain for at least three months, beginning incidental and unrelated to some traumatic event in the knee Pain with intensity of at least three points in the Visual Analogue Scale (VAS) of pain in the last week Limitation of the ankle dorsiflexion range of motion measured by the Lunge Test in the lower limb with Patellofemoral Pain History of surgery in the lumbar spine, hip, knee and / or ankle History of fractures in the lumbar spine, hip, knee and / or ankle History of patellar dislocation Presence of edema in the knee joint Presence of meniscal injury Injury of cruciate ligament and / or collateral ligaments Presence of tendonopathy in the patellar tendon, tendons of the goose and / or band leg tibial ilium Presence of Osgood-Schlatter Syndrome or Sinding-Larsen-Johansson Syndromes Presence of pain in the lumbar spine and / or hip
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 16.0-65.0, Pain Postoperative Pain Postoperative Complications Necrosis Pathologic Processes Mandibular molar teeth Diagnosed clinically with pulp necrosis Absence of spontaneous pain Pain on palpation or tenderness to percussion Periradicular radiolucency or widening of periodontal membrane space. 2- Patients' acceptance to participate in the trial. 3 Patients who can understand NRS scale and can sign the informed consent Primary teeth and permanent teeth with immature roots which require special endodontic treatment protocol that seeking for obtaining good apical seal, proper cleaning, shaping and obturation 2. Patients who have received antibiotics for the last 3 months before the study or any medication that could alter their perception of pain, inflammation and infection . 3. Teeth previously accessed or endodontically treated as they have low success rate . 4. Patients with diabetes, immune-compromising and immune-suppresion disease as the healing is much more slowly and more liable to infection . 5. Pregnant patients to avoid exposure to radiograph. Moreover, pain perception may be altered due to hormonal changes . 6. Teeth with deep pocket >4 mm as it has poor prognosis and deep pockets are harbor area for infection which need specific surgical and periodontal treatment . 7. Teeth that could not be isolated with a rubber-dam or could not be restorable. 8. Tooth associated with vertical root fracture, coronal perforation, calcification and external or internal root resorption as it has poor prognosis
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Irritable Bowel Syndrome Abdominal Pain Small Intestinal Bacterial Overgrowth Adults aged ≥18 years; flood victims who fulfilled the Rome III for IBS developed after flood, able to perform breath-testing, able to provide stool specimens, and able to complete three months of prospective intervention Adults who took antibiotics or probiotics three months prior to and after flood had taken place; previous abdominal surgery and presence of significant medical and psychiatric co-morbidities
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Diverticulum, Colon Diverticulitis All consecutive patients satisfying the following are recruited: 1. Acceptance to sign the Informed Consent form 2. Age >18 3. Instrumental evidence (endoscopic or radiological) of diverticula in the colon Refusal to sign the Informed Consent form 2. Inability to comply with the study procedures
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Intra Abdominal Infections Patient or the patient's legally acceptable representative able to provide a signed written informed consent prior to any study-specific procedures. 2. Adult patients ≥18 years of age 3. a. Intra-operative/post-operative enrollment with visual confirmation (presence of pus within the abdominal cavity) of an intra-abdominal infection associated with peritonitis including at least 1 of the following diagnosed during the surgical intervention: i. Cholecystitis with gangrenous rupture or perforation or progression of the infection beyond the gallbladder wall ii. Diverticular disease with perforation or abscess iii. Appendiceal perforation or peri-appendiceal abscess iv. Traumatic perforation of the intestines, only if operated on >12 hours after perforation occurs v. Secondary peritonitis (but not spontaneous bacterial peritonitis associated with cirrhosis and chronic ascites) vi. Intra-abdominal abscess (including of liver or spleen provided that there was extension beyond the organ with evidence of intraperitoneal involvement). OR: b. Pre-operative enrollment where one of the following surgical procedures are planned within 24 hours prior to the first dose of study drug: i. Open laparotomy, percutaneous drainage of an intra-abdominal abscess, or laparoscopic surgery. 4. Evidence of systemic inflammatory indicators, with at least one of the following: i. Fever (defined as body temperature >38°C) or hypothermia with a core body temperature <35°C ii. Elevated white blood cell count (>12,000 cells/mm3) iii. Drop in blood pressure (systolic BP must be <90 mmHg without pressor support) iv. Increased heart rate (>90 bpm) and respiratory rate (>20 breaths/min) v. Hypoxia (oxygen saturation ≤90 percent on room air) 5. Physical findings or symptoms consistent with intra-abdominal infection, with at least one of the following: i. Abdominal pain and/or tenderness, with or without rebound ii. Localized or diffuse abdominal wall rigidity iii. Abdominal mass iv. Nausea/vomiting v. Altered Mental Status 6. Specimen/s from the surgical intervention were sent for culture Patient diagnosed with traumatic bowel perforation undergoing surgery within 12 hours; perforation of gastroduodenal ulcers undergoing surgery within 24 hours. Other intra-abdominal processes in which the primary etiology was not likely to be infectious. 2. Patient has abdominal wall abscess or bowel obstruction without perforation or ischemic bowel without perforation. 3. Patient has simple cholecystitis or gangrenous cholecystitis without rupture, or simple appendicitis, or acute suppurative cholangitis; or infected necrotizing pancreatitis or pancreatic abscess. 4. Patient whose surgery included staged abdominal repair, or "open abdomen" technique, or marsupialization. 5. Patient known at study entry to have a complicated intra-abdominal infection caused by pathogens resistant to the study antimicrobial agents. 6. Patient needed effective concomitant systemic antibacterials (oral, IV, or intramuscular) or antifungals in addition to those designated in the 2 study groups, except vancomycin, linezolid, or daptomycin if started for known or suspected methicillin-resistant Staphylococcus aureus (MRSA) or Enterococcus spp. as per clinical study protocol (CSP). 7. Patient has perinephric infections or an indwelling peritoneal dialysis catheter. 8. Patient has suspected intra-abdominal infections due to fungus, parasites (e.g., amoebic liver abscess), virus, or tuberculosis. 9. Patient has a known history of serious allergy, hypersensitivity or any serious reaction to carbapenem antibiotics, or to other β-lactam antibiotics 10. Patient known to have any of the following laboratory values as defined below: 1. Hematocrit <25% or hemoglobin <8 g/dL 2. Absolute neutrophil count <1000/mm3 3. Platelet count <75,000/mm3 4. Bilirubin >3 x the upper limit of normal (ULN), unless isolated hyperbilirubinemia was directly related to the acute infection or known Gilbert's disease 5. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3 x ULN values at Screening. Patients with elevations of AST and/or ALT up to 5 x ULN will be eligible if these elevations are acute and directly related to the infectious process being treated. This must be documented 6. Alkaline phosphatase (ALP) >3 x ULN. Patients with values >3.0 x ULN and <5.0 x ULN are eligible if this value is acute and directly related to the infectious process being treated. This must be documented. 7. Estimated creeatinine clearance <50 mL/min 11. Patient has a body mass index >45 kg/m2. 12. Patient has II score >30. 13. Patient considered unlikely to survive the 4-week study period or has a rapidly progressive or terminal illness, including septic shock that was associated with a high risk of mortality. 14. Patient unlikely to respond to 10-14 days of treatment with antibiotics. 15. Patient received systemic antibacterial agents within the 72-hour period prior to study entry, unless either of the following pertained: a. Patient has a new infection (not considered a treatment failure) and both of the following were met: i. Patient received no more than 24 hours of total prior antibiotic therapy ii. Patient received ≤1 dose of a treatment regimen post-operatively and antibiotics were not received more than 6 hours post-procedure. b. Patient considered to have failed the previous treatment regimen i.e., pre-operative treatment of any duration with non-study systemic antimicrobial therapy for peritonitis or abscess permitted provided that all of the following are met: i. The treatment regimen had been administered for at least 72 hours and was judged to have been inadequate ii. The patient had an operative intervention that was just completed or was intended no more than 24 hours after study entry iii. Findings of infection were documented at surgery iv. Specimens for bacterial cultures and susceptibility testing were taken at operative intervention v. No further non-study antibacterials were administered after randomization. 16. Patient has a concurrent infection that may interfere with the evaluation of response to the study antibiotic. 17. Patient receiving hemodialysis or peritoneal dialysis. 18. Patient has a history of acute hepatitis in the recent past (3 months prior to study entry), chronic hepatitis, cirrhosis, acute hepatic failure, or acute decompensation of chronic hepatic failure. 19. Patient has past or current history of epilepsy or seizure disorders excluding febrile seizures of childhood. 20. Patient immunocompromised as evidenced by any of the following: 1. Human immunodeficiency virus infection, with either a recent (in the past 6 months) acquired immune deficiency syndrome-defining condition or a CD4 + T lymphocyte count <200/mm3 2. Systemic or hematological malignancy requiring chemotherapeutic or radiologic/immunologic interventions within 6 weeks prior to randomization, or anticipated to begin prior to completion of study 3. Immunosuppressive therapy, including maintenance corticosteroid therapy (>40 mg/day equivalent prednisolone) for 5 days or more. 21. Patient participating in any other clinical study that involved the administration of an investigational medication at the time of presentation, during the course of the study, or who had received treatment with an investigational medication in the 30 days prior to study enrollment, or had previously been enrolled in this study or had been treated with sulopenem. 22. Patient is in a situation or has a condition that, in the investigator's opinion, may interfere with optimal participation in the study. 23. Patient unlikely to comply with protocol e.g., uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study. 24. Patient has known inflammatory bowel disease (ulcerative colitis or Crohn's disease) or Clostridium difficile-associated diarrhea. 25. Patients with a history of blood dyscrasias 26. Patients with a history of uric acid kidney stones 27. Patients with acute gouty attack 28. Patients on chronic methotrexate therapy 29. Females of child-bearing potential who are unable to take adequate contraceptive precautions, have a positive pregnancy test result within 24 hours of study entry, are otherwise known to be pregnant, or are currently breastfeeding an infant. 30. Male subjects who do not agree to use an effective barrier method of contraception during the study and for 14 days post treatment
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Anesthesia, Local Patients 18 years and older with underlying pathologies requiring surgical intervention facilitated by a specific regional nerve block Informed consent executed Patients unable to understand and provide written consent Infection at the injection site Allergy to local anesthetic agents Medical condition obscuring visualization Known neuropathy at or around target nerve for the PNB Inability to communicate with the investigator or hospital staff
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Metastatic Carcinoma in the Adrenal Cortex Stage III Adrenal Cortex Carcinoma AJCC v8 Stage IV Adrenal Cortex Carcinoma AJCC v8 Unresectable Adrenal Cortex Carcinoma Histological confirmation of adrenocortical carcinoma (ACC) based on either: i). Weiss Score of >= 3 in patients who had earlier surgical resection OR ii). biopsy results compatible with ACC in the context of clinical setting highly suggestive of ACC (adrenal mass > 4 cm invading surrounding organs or associated with distant metastases) Locally advanced or metastatic disease not amenable to surgery with curative intent with measurable disease per Response Evaluation in Solid Tumors (RECIST) 1.1 as determined by the investigator based on an assessment of all known disease sites by computerized tomography (CT) scan or magnetic resonance imaging (MRI) of chest/abdomen/pelvis within 28 days before the first dose of cabozantinib. In patients with intravenous (IV) contrast allergy or borderline renal function, CT without IV contrast or 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) CT may be used as clinically indicated Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 Recovery to baseline or =< grade 1 CTCAE v.4.0 from toxicities related to any prior treatments, unless adverse events (AEs) are clinically nonsignificant and/or stable on supportive therapy Life expectancy of at least 3 months Absolute neutrophil count (ANC) >= 1500/mm^3 without colony stimulating factor support (obtained within 28 days prior to the first dose of cabozantinib) Platelets >= 100,000/mm^3 (obtained within 28 days prior to the first dose of cabozantinib) Hemoglobin >= 9 g/dL (obtained within 28 days prior to the first dose of cabozantinib) Bilirubin =< 1.5 x the upper limit of normal (ULN). For subjects with known Gilbert's disease, bilirubin =< 3.0 mg/dL (obtained within 28 days prior to the first dose of cabozantinib) Serum albumin >= 2.8 g/dl (obtained within 28 days prior to the first dose of cabozantinib) Received cytotoxic chemotherapy, radiation therapy, or targeted therapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within 28 days of study enrollment For patients who received mitotane within 6 months of consenting, mitotane should have been stopped at least 28 days prior to study enrollment AND to have mitotane serum level of < 2 mg/L Prior treatment with cabozantinib or other cMET inhibitors Known brain metastases or cranial epidural disease unless adequately treated with radiotherapy and/or surgery (including radiosurgery) and stable for at least 4 weeks before the first dose of study treatment. Eligible subjects must be neurologically asymptomatic and without corticosteroid treatment at the time of the start of study treatment The subject has not recovered to baseline or CTCAE =< grade 1 from toxicity due to all prior therapies except alopecia and other non-clinically significant AEs Prothrombin time (PT)/ international normalized ratio (INR) or partial thromboplastin time (PTT) test >= 1.3 x the laboratory ULN within 28 days before the first dose of study treatment Concomitant anticoagulation with oral anticoagulants (e.g., warfarin, direct thrombin and Factor Xa inhibitors), platelet inhibitors (e.g., clopidogrel) or therapeutic doses of low molecular weight heparins (LMWH). Low dose aspirin for cardioprotection (per local applicable guidelines) and low-dose LMWH are permitted. Anticoagulation with therapeutic doses of LMWH is allowed in subjects who are on a stable dose of LMWH for at least 6 weeks before the first dose of study treatment, and who have had no clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor Severe and uncontrolled Cushing syndrome despite medical management (e.g., systolic blood pressure > 160 mmHg or hyperglycemia with fasting glucose above 300 mg/dL) The use of strong CYP3A4 inhibitor (with the exception of ketoconazole) The subject has experienced any of the following: a. clinically-significant gastrointestinal bleeding within 6 months before the first dose of study treatment; b. hemoptysis >= 0.5 teaspoon (2.5 mL) of red blood within 3 months before the first dose of study treatment; c. any other signs indicative of pulmonary hemorrhage within 3 months before the first dose of study treatment. Tumor invading any major blood vessel at the time of study enrollment
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-37.0, Cesarean Section Complications singleton pregnancy previous PID any medical or psychiatric patients with BMI ≥ 40 multigravidas chronic analgesia use allergy to analgesics multiple pregnancies are also excluded
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Biliary Colic Cholecystitis ASA I or II Confirmed diagnosis of biliary colic or cholecystitis Normal LFTs Patients unable tor unwilling to consent BMI >40
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Appendicitis and 65 years old A diagnosis of suppurative or gangrenous appendicitis based on: 1. metastatic right lower abdominal pain 2. lower abdominal tenderness and/or rebound tenderness 3. pyrexia (axillary temperature ≥ 37.5 °C), a WBC > 10*109/L on routine blood examination 4. Voluntary signing of written informed consent patients with an allergy to nitroimidazole patients with a history of antibiotic therapy within the last 48 hours patients with any condition likely to require broad spectrum antibiotics patients who can not evaluate the efficacy or difficult to complete the desired course of treatment ALT and / or AST ≥ 1.5 times the ULN, and / or serum creatinine ≥ the ULN patients with severe systemic diseases likely to affect therapy (e.g., cardiovascular abnormalities, unstable angina, high blood pressure, severe neuropathy, or epilepsy) patients with other diseases or use other drugs which may interfere with the efficacy or safety of the drug patients who participated other clinical trials within 6 months before the start of the trial Pregnant women, breastfeeding women, women of childbearing age without effective contraceptive
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Tendon Injuries Achilles Tendinopathy Inflammation Activity related pain in the achilles tendon Palpation pain in the achilles tendon Onset of symptoms within the last 3 months Previous injury in the achilles tendon on the ipsilateral side Recent infection around the achilles tendon Previous surgery in the achilles tendon Contraindications for NSAID treatment NSAID treatment for the current injury Medication with NSAID interaction
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-80.0, Pain, Postoperative Preemptive Peripheral Nerve Block Acute Pain adults between the ages of 20 and 80 2. bilateral hallux valgus surgery on the same day 3. ASA class 1 or 2 4. Patients who have voluntarily agreed in writing to participate in the trial Patient with side effects on local anesthetics or steroids 2. Patient who are taboo of peripheral nerve block such as blood clotting disorder, infection, etc. 3. Patients with uncontrolled medical or psychiatric problem 4. Patient does not agree to participate in the study 5. Patients who are pregnant or lactating
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Influenza A, Influenza B Subjects will be recruited from the general population as they present to the clinical facility. Subjects must have had a fever within the last two days and exhibiting one or more symptoms characteristic of influenza. They must meet the following to be eligible for enrollment: 1. Male or Female of all ages (with appropriate consent). 2. The subject must have had of a fever, ≥ 37.8º C (100º F), within the last two days. 3. Must also be currently exhibiting one or more of the following symptoms characteristic of influenza-like-illness (ILI). 1. Nasal congestion 2. Rhinorrhea 3. Sore throat 4. Cough 5. Headache 6. Myalgia 7. Malaise Has undergone treatment with anti-influenza antivirals within the previous 7 days, to but not be limited to, Amantadine, Rimantadine, Ribavirin, Oseltamivir, Zanamivir or any other antiviral currently available in these classes. 2. Has been vaccinated by means of an influenza nasal spray/mist vaccine within the previous 7 days. 3. Unable to understand and consent to participation; for minors this includes parent or legal guardian
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-45.0, Low Back Pain Pregnancy Criteria:Inclusion Subjects 18-45 years old singleton gestation in the third trimester (28 weeks and on) pregnancy-related lumbopelvic pain capable of following basic instructions Subjects with a history of lumbopelvic pain that required healthcare management within a year prior to pregnancy acute infectious or inflammatory process diagnosed mental health disorder substance abuse documented diagnosis of fibromyalgia
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Appendicitis Admission for right iliac fossa pain Under 18 years unwilling to provide informed consent pregnant women diabetic immunosuppressed immunosuppression or steroid treatment within last 12 months learning disability Non-english speakers
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-35.0, Patellofemoral Pain Syndrome Patellofemoral pain during physical activities such as running, jumping, squatting, and going up or down stairs for at least 4 weeks The onset of pain is required to be atraumatic in nature Exhibit two of the following clinical on assessment: pain on direct compression of the patella against the femoral condyles with the knee in full extension, tenderness of the posterior surface of the patell on palpation, pain on resisted knee extension, and pain with isometric quadriceps muscle contraction against suprapatellar resistance with the knee in 15° of flexion Negative findings in the examination of knee ligaments, menisci, bursae, synovial plicae, Hoffa's fat pad, iliotibial band, and the hamstring, quadriceps, and patellar tendons and their insertions With patellofemoral instability, or With other knee diagnoses Any previous surgery or severe trauma in the affected limb Inflammatory joint disease or tumors in the affected limb
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-999.0, Appendicitis Acute Including 1. Clinical diagnosis of appendicitis and undergo laparoscopic appendectomy 2. Age more than 20 years 3. Well comprehensive in speaking Chinese Age no more than 20 years 2. Pregnancy 3. Can not cooperate with evaluation 4. Convert to open surgical method, resect more organs than appendix 5. Using patient control analgesia 6. Allergy to local anesthetic agent
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Healthy Musculoskeletal Pain pain free blood pressure under 140/90 mmHg ability of therapist to locate necessary trigger points on participant blood pressure over 140/90 mmHg inability of therapist to locate necessary trigger points on participant systemic medical condition known to affect sensation (i.e. diabetes) regular use of prescription pain medication to manage pain current or history of chronic pain condition currently using blood thinning medication any blood clotting disorder such as hemophilia any contraindication to application of ice or cold pack, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, and circulatory compromise non-English speaking
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-50.0, Chronic Fatigue Syndromes The occurrence of four or more of the following symptoms Subjective memory impairment Tender lymph nodes Muscle pain Joint pain Headache Unrefreshing sleep Post-exertion malaise lasting for more than 24 hours Active, unresolved, or suspected medical disease Psychotic, melancholic or bipolar depression (but not uncomplicated major depression) Psychotic disorders Dementia Anorexia or bulimia nervosa Alcohol or other substance misuse Severe obesity
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Differentiated Thyroid Gland Carcinoma Thyroid Gland Follicular Carcinoma Thyroid Gland Papillary Carcinoma Prior treatment with therapeutic dose of radioactive iodine (> 50 mCi) with evidence of RAI uptake on delayed scan and with progression (biochemical or anatomic) within 12 months of RAI Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 (Karnofsky ≥ 80%) Leukocytes ≥ 3,000/µL Absolute neutrophil count ≥ 1,500/µL Platelets ≥ 100,000/µL Total bilirubin within normal institutional limits Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) ≤ 2.5 x institutional upper limit of normal Creatinine within normal institutional limits OR Creatinine clearance ≥ 60 mL/min/1.73 m² for patients with creatinine levels above institutional normal Confirmed diagnosis of differentiated thyroid cancer (follicular or papillary thyroid cancer and their variants) Patients who have received RAI within 12 weeks of planned retreatment Prior receipt of cumulative RAI doses in excess of 1000 mCi Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities > grade 1) Patients who are receiving any other investigational agents Patients with previously untreated and or symptomatic brain metastases are excluded from this clinical trial because of the risk of intracranial bleeding with angiogenic agents and tumoral swelling from RAI History of allergic reactions attributed to compounds of similar chemical or biologic composition to lenvatinib Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements Patients with uncontrolled hypertension (requirement for more than 2 blood pressure [BP] medications or grade 2 or higher BP elevation while on adequate doses of not more than 2 antihypertensive agents) are excluded from the study because one of the significant adverse events of lenvatinib is worsening hypertension Fridericia's corrected QT (QTcF) interval prolongation greater than 500 ms Recent arterial thromboembolic event within the previous 6 months
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Mesenteric Ischemia age> 18 years Acute abdominal pain requiring an injected abdominal injected CT scan, at best at non-injected / early arterial / portal time Admitted or attended in Beaujon and / or Bichat hospitals Patient covered by a social security scheme Written consent • lack of abdominal CT scan
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Non Enhanced MSCT Abdomen in Diagnosis of Acute Abdomen Any Case Of Acute Abdominal Pain suspected to be surgical cases in adults If pediatric If associated with pregnancy The patient have severe cardiac or respiratory disease ,cant to lie supine If suspected medical case of acute abdomen
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Appendicitis Adult patients ≥ 18 years of age Imaging confirmed diagnosis of appendicitis (ultrasound or CT or MRI) Expected time of operation between 2200 and occurs within 6 hours of the decision to operate Patients with hemodynamic instability Patients with suspected sepsis Unknown diagnosis Presence of abscess on CT Scan Diagnosis of missed appendicitis Pregnancy Patients who are not surgical candidates Patients who are not competent to sign consent
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