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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-84.0, Lumbar Radiculopathy Lesion of Sciatic Nerve, Left Lower Limb Lesion of Sciatic Nerve, Right Lower Limb Lumbar Spinal Stenosis Lumbar Spondylosis Lumbago With Sciatica, Left Side Lumbago With Sciatica, Right Side Patients diagnosed with chronic low back pain (lasting more than 3 months) who are between 18 to 84 years old will be eligible for the study. will be specified by the following the 2017/2018 International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes associated with chronic low back pain M54.16 Lumbar radiculopathy G57.01 Lesion of sciatic nerve, right lower limb G57.02 Lesion of sciatic nerve, left lower limb M48.061 Lumbar spinal stenosis, without neurogenic claudication M48.062 Lumbar spinal stenosis, with neurogenic claudication M47.816 Lumbar spondylosis M48.07 Lumbar spinal stenosis, lumbosacral M54.41 Lumbago with sciatica, right side M54.42 Lumbago with sciatica, left side Patients with diabetic neuropathy, congenital lumbar and sacral abnormalities, lumbar fracture, multiple myeloma, metastatic bone disease, history of spinal and/or pain lasting less than three months will be excluded from the study
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Musculoskeletal Pain Neck Pain currently experiencing neck pain with or without arm pain neck pain symptom intensity rated as 4/10 or higher during the last 24 hours neck pain for greater than or equal to 3 months non-English speaking systemic medical conditions known to affect sensation (e.g. diabetes, hypertension) history of neck surgery or fracture within the past 6 months current history of chronic pain condition other than neck pain diagnosis of cervical radiculopathy or cervical myelopathy history of whiplash; g) currently using blood thinning medication any blood clotting disorder such as hemophilia any contraindication to application of ice, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, and circulatory compromise
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-75.0, Pain, Chronic Pain, Back Pain, Radiating Age ≧20 and ≦75 2. Have a symptom of back or lower limb pain with a diagnosis related to spinal lesion, herniated disc, nerve injury, stenosis, failed back surgery syndrome (FBSS), complex regional pain syndrome (CRPS) or ischemic lower limb pain and have pain history of >6 months. 3. Have an average pain score >5 by Visual Analogue Scale (VAS) on inclusion. 4. Has failed to achieve adequate pain relief from prior pharmacologic treatments. 5. In the judgement of the investigator, the subject is an appropriate candidate for the trial procedure. 6. The subject is willing and able to comply with the procedure and requirements of this trial. 7. The participant is able to understand and provide informed consent, and has signed their written informed consent in accordance with Institutional Review Board (IRB) requirements Have evidence of a mental or psychological condition that affects pain perception and has difficulty/disability performing objective pain assessment, or have previously failed mental or psychological assessments administered by a psychiatrist that may be deemed to indicate the subject's lack of suitability for participation in this study. 2. Subject has exhibited unstable pain condition within the past 30 days as interviewed by Investigator. 3. Be on anticoagulant medication with International Normalized Ratio (INR) >1.5 or platelet count less than 100,000/μL, peripheral vascular diseases (PVDs), visceral pain or uncontrolled Diabetes mellitus (DM). 4. Has had corticosteroid therapy at an intended site of stimulation within the past 30 days. 5. Pain medication(s) dosages(s) are not stable for at least 30 days at investigator's discretion. 6. Currently has an active implantable device including International Classification of Diseases (ICD), pacemaker, spinal cord stimulator or intrathecal drug pump or subject requires magnetic resonance imaging (MRIs) or diathermy. 7. Have a current diagnosis of cancer with active symptoms. 8. Have a known terminal illness with life expectancy less than one year. 9. Have a systematic or local infection, which may increase study risk. 10. Currently has an indwelling device that may pose an increased risk of infection. 11. Be pregnant or breast feeding. 12. Have a medical history of drug or alcohol addiction within the past 2 years. 13. Participation in any investigational study in the last 30 days or current enrollment in any trial. 14. Be currently involved in an injury claim law suit or medically related litigation, including workers compensation. 15. Be a prisoner
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Anastomotic Leak Colorectal Surgery Patients submitted to laparoscopic/robotic/open/converted ileo-colo-rectal resection with anastomosis (both intra and/or extra-corporeal), including planned Hartmann's reversals. 2. American Society of Anesthesiologists' (ASA) class I, II or III 3. Elective surgery 4. Patients' written acceptance to be included in the study American Society of Anesthesiologists' (ASA) class IV-V 2. Patients with stoma before or at operation 3. Simple stoma closure 4. Transanal procedure 5. Pregnancy 6. Ongoing infection prior to surgery 7. Hyperthermic intraperitoneal chemotherapy for carcinomatosis
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Abdominal Pain • Acute presentation with abdominal pain and/or tenderness which is most marked in the right lower abdomen Age<18 Age>60 Pregnancy Patients with a firm clinical diagnosis of appendicitis where surgical management is indicated at presentation Patients who have undergone CT scanning within the past two months Patients with cognitive impairment who would lack capacity to give consent Inability to understand written or spoken English Patients who have previously undergone appendicectomy
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 13.0-65.0, Appendicitis Polymer Clips Surgitie Patients of either gender with age ranging from 15 to 60 years. 2. Patients with score of 7 or above on admission Patients having co-morbid factors such as diabetes, chronic liver disease and ischemic heart disease on previous / past medical history. 2. Patients with history and clinical findings suggestive of appendicular mass. 3. Patients with known gastrointestinal malignancies. 4. Patients with history of any abdominal surgery
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Inflammatory Bowel Diseases Irritable Bowel Syndrome Coeliac Disease IBS patients IBD patients in remission Coeliac patients on gluten free diet Active IBD Coeliac patients non compliant to gluten free diet
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Catastrophizing Pain Pain, Somatic Chronic Low Back Pain Low back pain group chronic low back pain ( lasting more than 3 months) intensity of ≥ 3/10 on a numeric rating scale pain is located in the area between the gluteal folds below to the thoracolumbal junction above. Controls: No current or previous history of musculoskeletal pain of ongoing nature Applies for both groups Signs of radicular pain or other specific medical conditions e.g. rheumatologic disease or diabetes Pregnancy
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Chronic Pain Adults ages 18 able to understand English and comply with study protocol Peripheral neuropathy from HIV or chemotherapy History of fibromyalgia Headaches Chronic Pain day average numeric pain score of 5/10 or greater at baseline evaluation Subjects receiving remuneration for their pain treatment Subjects that are incarcerated Subjects unable to read English and complete assessments Addictive behavior, severe clinical depression, or psychotic features
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-50.0, Ultrasound Lumbar spinous processes impalpable. Elective caesarean delivery for singleton pregnancies BMI >30 No contraindications to neuraxial block Signed informed consent Neuraxial Block planned
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Complicated Acute Appendicitis CAA suspected pre-operatively through a Saint-Antoine score ≤3 and confirmed peroperatively by the presence of a perforated appendicitis, extraluminal fecaliths, abscesses and/or localized peritonitis (pus in one or two abdominal quadrants). 2. Laparoscopic appendectomy. 3. Aged 18 or over 4. Written, informed consent Pre-operative Patients with cardiac valvulopathy Immunodepressed patients Diabetic patients Patients who have received an antibiotic treatment within 3 months before the surgery (and having a potential impact on the intestinal flora) Related to the diagnosis: other diseases (Crohn's disease, ulcerative colitis, treatment with an immunosuppressive therapy) Related to the severity of the appendicitis A Saint-Antoine score of 4 or 5 (non-complicated acute appendicitis) Severe sepsis, septic shock, generalized peritonitis Related to the treatment
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-45.0, Pain, Neck Pain, Back Myofascial Trigger Point Pain Myofascial Pain Mitochondrial Pathology Male patients aged 18-45 years Clinical diagnosis of myofascial pain syndrome within the region of the shoulder-neck muscles or the lumbogluteal region and the presence of an MTrP, defined as a firm palpation of a hard, tender nodule resulting in a spontaneous pain complaint with symptoms present for 1 to 12 months Signs that the participant's prescriptive compliance was not expected (e.g., lack of cooperation) Disorders of the respiratory tract Neurological disorders, in particular neurodegenerative and neuromuscular diseases Disorders of the cardiovascular system or the musculoskeletal system Civil servants and military service personnel
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Atrial Fibrillation Older than 18 years old Nonvalvular and long-standing persistent atrial fibrillation confirmed by echocardiography and electrocardiography respectively Written informed consent Secondary atrial fibrillation caused by other reversible diseases Left atrial diameter >55mm confrimed by Transthoracic echocardiography Intracardial mass or thrombus Previous cardiac surgery Uncontrolled heart failure or LVEF less than 30% Severe chest wall deformity Possibly pleural adhesion or pericardial adhesion caused by previous thoracic surgery, tuberculosis or constrictive pericarditis Severe comorbidities (e.g. severe CAD, severe renal failure, severe liver failure) Life expectancy less than 2 years (e.g. patients with MODS or cancer) Unsuitable for radiation exposure (e.g. pregnancy)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 50.0-999.0, Pain Mild to moderate patients with Alzheimers disease (group 1) Healthy participants ( group 2) Chronic pain conditions Other medical, psychiatric or neurological disorders Use of pain-reliving medication 24 hours prior to testing
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Aneurysm Abdominal Endovacular Repair patients suffering from infrarenal abdominal aortic aneurysm undergoing endovascular aneurysm repair Leukocytosis (white blood cell count [WBC]> 10,000 / mL) and elevated body temperature Signs of gangrene Previous trauma or surgery two months before enrolling in the study Previous implantation of endoprothesis Any autoimmune disease or systemic inflammatory condition Any malignancy Use of anti-inflammatory drugs, chemotherapeutic agents, immunosuppressants or anticoagulants Severe severe renal impairment (GFR < 30 ml / min) and Absolute contraindications of NSAIDs such as: NSAID-allergic patients, patients who have experienced asthma attacks following the use of acetylsalicylic acid or other anti-inflammatory nonsteroidal drugs, patients with nasal polyps, patients with anaphylactic or other severe NSAID allergies, severe hepatic insufficiency, heart failure patients (moderate to severe), patients with ischemic heart disease or other vascular diseases, presence of old or active gastric or ulcer of duodenum, history of gastrointestinal haemorrhage in the past, proctitis or recent rectal bleeding, a history of inflammatory bowel disease (ulcerative colitis, Crohn's disease)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Appendicitis age ≥18 years acute appendicitis laparoscopic approach signed informed content necrosis or advanced inflammatory changes in the area of appendicular stump
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 3.0-15.0, Chronic Appendicitis Patients were eligible if they were between 3 and 15 years of age, and they suffered from chronic appendicitis. 2. US showing hyperemia and fecalith, ≤ 1.1 cm in diameter, compressible or non-compressible, no abscess, no phlegmon or CT showing hyperemia and fecalith, fat stranding, ≤ 1.1 cm in diameter, no abscess, no phlegmon consisted of (a history of) chronic back pain 2. previous abdominal surgery (with the exception of diagnostic laparoscopies or a laparoscopic sterilization) 3. specific gastro-intestinal entities (such as inflammatory bowel disease) 4.gynaecological disease (all female patients consulted a gynaecologist)
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Appendicitis Acute Appendicitis With Rupture Acute Appendicitis With Peritonitis Acute Appendicitis Without Peritonitis Patients with any stage of acute appendicitis except 3B according to Gomes classification Class I-II surgical patients according to the classification of The American Society of Anesthesiologists (ASA) Patient refusal to participate in the study or to sign the informed consent form Language barrier Transfer to the intensive care unit (ICU) after surgery ASA class ≥ III Conversion to open procedure Appendicular mass found during laparoscopy Gomes 3B appendicitis requiring immersion of the appendicular stump Pregnancy
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Appendicolith Appendicitis Appendicitis With Perforation Appendicitis Peritonitis Appendiceal Abscess Appendicitis Acute All adult patients scheduled to undergo laparoscopic appendectomy. Ages eligible for study: >18 Sexes eligible for study: All Patients who decline to join the study Patients under 18 years old Patients with contraindication to undergo laparoscopic surgery Patients without appendicular disease found at laparoscopy (such as complicated inflammatory bowel disease, tumor, complicated diverticula, gynecological disorder) Patients undergoing open appendectomy
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-50.0, Healthy Epicondylitis of the Elbow for pain-free participants no history of upper quadrant pain symptoms the year preceding the study no history of upper quadrant surgery presence of a latent trigger point in the extensor carpi radialis brevis muscle for patients with elbow pain pain over the lateral side of the elbow pain on palpation over the lateral epicondyle or the associated common wrist extensor tendon elbow pain with either resisted static contraction or stretching of the wrist extensor muscles presence of an active trigger point in the extensor carpi radialis brevis muscle bilateral symptoms older than 50 years of age previous surgery or steroid injections other diagnoses of upper extremity (shoulder pathology, cervical radiculopathy, cervical whiplash) history of cervical or upper extremity trauma history of musculoskeletal medical conditions (rheumatoid arthritis, fibromyalgia)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 8.0-18.0, Appendicitis Chronic Post-Procedural Pain Children between the ages of 8-18 years who underwent appendectomy who had ASA I physical score who agree to participate for this research Children who aged under 8 and over 18 years who had ASA II and those with higher physical score who had previously undergone surgery from the right lower abdomen who had preoperative pain complaint over 6 month who had psychiatric disorders who do not agree to participate
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 19.0-999.0, Anesthesia, Spinal Cesarean Section Spinal Ultrasound American Society of Anesthesiologists physical status II-III parturients Full term singleton pregnancy Body mass index ≥ 35 Kg/m2 Age < 19 years Women presenting in labor Contraindications to neuraxial anesthesia (Coagulopathy, increased intracranial pressure, or local skin infection) Significant spinal deformities or previous spinal surgery Preeclampsia
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Appendicitis The patients who will undergo to Laparoscopic Appendectomy for Acute Apandisitis older than 18 years old Perforated apandisitis Plastrone apndisitis
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 2.0-17.0, Complicated Appendicitis Perforated Appendicitis Age: 2 to 17 years of age Diagnosis of perforated appendicitis at laparoscopy Development of a post-appendectomy abscess that is treated with percutaneous drainage Patients who are allergic to ampicillin
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 50.0-70.0, Colon Cancer Only operable cases of right colon cancer by (CT scan criteria) which 1. No permeation of surrounding fat planes. 2. No encasement of major vascular structures. 3. No extensive local spread. 4. No distant metastases or peritoneal infiltration were included in this study All cases with perforation or obstruction. 2 Metastatic colon cancer. 3 Patients undergoing colectomy including another part of the colon than right colon
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-79.0, Abdominal Pain Zoster With Other Complications Patients aged ≥ 18, and < 80 years ER-visited patients with acute abdominal pain Numerical rating scale (NRS) score ≥ 4 Unresponsive to gastrointestinal motility drug, antacid Unwilling or unable to give informed consent forms Patients taking antiviral agents Patients complaining mild abdominal pain (NRS score ≤ 3)
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-70.0, Pseudoachondroplasia The diagnosis of pseudoachondroplasia is based on clinical assessment either in person or by photographic review by skeletal dysplasia specialist (JTH) Healthy beyond pseudoachondroplasia associated complications Current use of resveratrol Current use of blood thinners, lovastatin, ketoconazole, itraconazole, fexofenadine and triazolam Other non-pseudoachondroplasia related health conditions, e.g. cancers Pregnancy or breastfeeding. Women must use adequate contraception during the study Participation in another clinical study and/or using investigational agents Use of Non-steroid anti-inflammatory (NSAIDs) or aspirin Current use of Alfentanil, Cyclosporine, Dihydroergotamine, Dofetilide, Ergotamine, Fentanyl, Flibanserin, Oxycodone, Pimavanserin, Pimozide, Quinidine, Saquinavir, Sirolimus, Tacrolimus, Temsirolimus, Theophylline, Tizanidine, Thioridazine, Fosphenytoin, Phenytoin or Warfarin Baseline level of pain of 2 or higher on 10 point scale Platelet count below 50,000 per ul on baseline complete blood count (CBC)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 16.0-85.0, Fascioliasis vague gastrointestinal disturbances intermittent eosinophilia biliary obstruction biliary colic pain intermittent jaundice right upper-quadrant abdominal tenderness
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Deep Vein Thrombosis Thromboses, Venous Thrombosis Embolism Postthrombotic Syndrome Pulmonary Embolism case of venous thrombosis of a limb or pulmonary embolus
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.083-18.0, Kawasaki Disease Appendicitis Patients with Kawasaki disease Acute abdomen requiring surgery Patients with chronic gastrointestinal disease Incomplete data on the charts
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Plantar Fascitis Calcaneus Spur Pain when the plantar fascia is palpated Imaging of calcaneal spur radiographically Description of the first step pain, after prolonged resting or awakening in the morning Continue with pain despite other conservative methods (NSAI, exercise, etc.) History of steroid injection in the heel region for the same diagnosis in the last three months Rheumatic disease Coagulopathy, thrombophlebitis, neoplasia, systemic inflammatory diseases Foot and or lumbar surgery, symptoms of lumbar radiculopathy
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 16.0-65.0, Osteochondral Fracture of Talus Patients with a symptomatic osteochondral lesion of the Talus Magnetic resonance of the ankle showing osteochondral injury of a single talus, with perilesional oedema Recurrent osteochondral lesions of the talus Multiple osteochondral lesions Severe ankle instability, requiring open repair History of a previous foot or ankle surgery of the ipsilateral foot Rheumatoid arthritis Inability to return to the surgery site to practice long-term follow-up evaluations or lack of readiness to complete the indicated evaluation forms Patients with a qualitative or quantitative commitment that prevents consent or assent their participation in the study
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Surgery Breast Cancer Pain, Postoperative Pain, Chronic women > 18 years old with "American Society of Anesthesiologists-ASA" physical status 1 to 3 with unilateral breast cancer adenocarcinoma treated surgically by conservative tumorectomy associated or not to sentinel lymph node dissection on an ambulatory basis None
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Differentiated Thyroid Gland Carcinoma Follicular Variant Thyroid Gland Papillary Carcinoma Poorly Differentiated Thyroid Gland Carcinoma Refractory Differentiated Thyroid Gland Carcinoma Refractory Thyroid Gland Carcinoma Tall Cell Variant Thyroid Gland Papillary Carcinoma Thyroid Gland Follicular Carcinoma Thyroid Gland Hurthle Cell Carcinoma Thyroid Gland Papillary Carcinoma Patients must have histologically or cytologically confirmed papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), or Hurthle cell thyroid cancer (HTC). Follicular variant of PTC or any of the above mixed histology will be allowed, as well as tall cell, insular, or poorly-differentiated thyroid cancers. Patients with anaplastic thyroid cancers (ATC) or medullary thyroid cancers (MTC) are not eligible Patients must have measurable disease as defined by Response Evaluation in Solid Tumors (RECIST) v1.1 Patients must have radioactive iodine (RAI)-refractory/resistant disease as defined by one or more of the following One or more measurable lesions that do not demonstrate RAI uptake Progressive disease (PD) (new lesion or progression of previously known lesions), as defined by v1.1, within 12 months of prior RAI therapy One or more measurable lesion present after cumulative RAI dose of > 600 mCi, or Fluorodeoxyglucose (FDG)-positron emission tomography (PET) scan-positive disease (SUV >= 5 in tumor lesion) The patient's disease must have progressed on one line of VEGFR-targeted therapy (including, but not limited to, sorafenib, sunitinib, vandetanib, pazopanib, or lenvatinib, etc.) as defined by PD per v1.1 while receiving VEGFR-targeted therapy. Patients who have received more than one line of prior VEGFR-targeted therapy will not be eligible Prior external beam radiation to extra-osseous disease, systemic cytotoxic chemotherapy or BRAF or non-VEGFR-targeted therapies will be allowed, provided that > 4 weeks has elapsed since receiving prior treatment. Radiation to bone metastases is allowed up to 2 weeks prior to initiation of study treatment Patients must not have had prior treatment with XL184 (cabozantinib), any MET-targeting tyrosine kinase inhibitor (TKI), or any MET-targeting monoclonal antibody (MetMAb), such as onartuzumab Patients must not have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T cell co-stimulation or immune checkpoint pathways Patients must not have a tumor invading or encasing any major blood vessels, and must not have evidence of tumor invading the gastrointestinal (GI) tract (esophagus, stomach, small or large bowel, rectum, or anus), or any evidence of endotracheal or endobronchial tumor within 28 days before the first dose of XL184 (cabozantinib) Patients must not have a diagnosis of another malignancy within 2 years before the first dose of study treatment, except for superficial skin cancers, or localized, low grade tumors deemed cured and not treated with systemic therapy. Adjuvant hormonal therapy for history of prostate or breast cancer is allowed Patients must not have received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within 4 weeks, or nitrosoureas/ mitomycin C within 6 weeks, before the first dose of study treatment. Patients may continue on bone-modifying agents (denosumab or bisphosphonates) with caution Patients must not have received radiation therapy To the thoracic cavity, abdomen, or pelvis within 4 weeks before the first dose of study treatment To bone metastases within 14 days before the first dose of study treatment To any other sites within 4 weeks before the first dose of study treatment Patients must not have clinically relevant, ongoing complications from prior radiation therapy. Palliative (limited-field) radiation therapy is permitted as long as the patient does not have disease progression according to v 1.1
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 1.0-31.0, B Acute Lymphoblastic Leukemia B Lymphoblastic Lymphoma Down Syndrome All B-ALL patients must be enrolled on APEC14B1 and consented to Screening (Part A) prior to treatment and enrollment on AALL1731. APEC 14B1 is not a requirement for B-LLy patients. B-LLy patients may directly enroll on AALL1731 Age at diagnosis Patients must be >= 365 days and < 10 years of age (B-ALL patients without DS) Patients must be >= 365 days and =< 31 years of age (B-ALL patients with DS) Patients must be >= 365 days and =< 31 years of age (B-LLy patients with or without DS) B-ALL patients without DS must have an initial white blood cell count < 50,000/uL (performed within 7 days prior to enrollment) B-ALL patients with DS are eligible regardless of the presenting white blood cell count (WBC) (performed within 7 days prior to enrollment) Patient has newly diagnosed B-cell ALL, with or without Down syndrome: > 25% blasts on a bone marrow (BM) aspirate OR if a BM aspirate is not obtained or is not diagnostic of B-ALL, the diagnosis can be established by a pathologic diagnosis of B-ALL on a BM biopsy OR a complete blood count (CBC) documenting the presence of at least 1,000/uL circulating leukemic cells Patient must not have secondary ALL that developed after treatment of a prior malignancy with cytotoxic chemotherapy. Note: patients with Down syndrome with a prior history of transient myeloproliferative disease (TMD) are not considered to have had a prior malignancy. They would therefore be eligible whether or not the TMD was treated with cytarabine With the exception of steroid pretreatment or the administration of intrathecal cytarabine, patients must not have received any prior cytotoxic chemotherapy for either the current diagnosis of B ALL or B LLy or for any cancer diagnosed prior to initiation of protocol therapy on AALL1731 For patients receiving steroid pretreatment, the following additional apply Non-DS B-ALL patients must not have received steroids for more than 24 hours in the 2 weeks prior to diagnosis without a CBC obtained within 3 days prior to initiation of the steroids DS and non-DS B-LLy patients must not have received > 48 hours of oral or IV steroids within 4 weeks of diagnosis Patients who have received > 72 hours of hydroxyurea B-ALL patients who do not have sufficient diagnostic bone marrow submitted for APEC14B1 diagnostic testing and who do not have a peripheral blood sample submitted containing > 1,000/uL circulating leukemia cells Patient must not have acute undifferentiated leukemia (AUL) Non-DS B-ALL patients with central nervous system [CNS]3 leukemia (CNS status must be known prior to enrollment) Note: DS patients with CNS3 disease are eligible but will be assigned to the DS-High B-ALL arm. CNS status must be determined based on a sample obtained prior to administration of any systemic or intrathecal chemotherapy, except for steroid pretreatment
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Morbid Obesity Opioid-Related Disorders Surgery--Complications Sleep Apnea Syndromes Body mass index (BMI) equal or greater than 35 kg/m2 American Society of Anesthesiologists (ASA) physical status I III patients Scheduled to undergo laparoscopic roux-en-Y gastric bypass or gastric sleeve placement surgery for weight loss Chronic obstructive pulmonary disorder (COPD) Treatment with continuous positive airway pressure (CPAP) in the past three months Severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder Chronic pain condition that was being treated with opioids Patients with a hematocrit lower than 35%
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 15.0-45.0, Appendectomy Pain, Postoperative Length of Stay with acute appendicitis confirmed clinically by pain in right iliac fossa accompanied by right iliac fossa tenderness, elevated leukocyte count (>8*109/ml) without a palpable mass and on radiological investigation admitted through emergency department were included in the study • Perforated appendix (had been assesses on abdominal ultrasound or per-operatively Palpable mass in the right lower quadrant as assessed by clinical exam History of Co-morbidities e.g. known diabetic, known hypertensive, cirrhosis as shown by ultrasonography and coagulation disorder (to be determined by low platelet count; <140 *109, deranged PT and APTT).(PT=13sec, APTT= 33 sec) Patients unfit for surgery (ASA Grade III/IV) Patient who did not give informed consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-55.0, Low Back Pain Patient aged 20 to 55 years old Presenting an episode of acute common low back pain diagnosed in the GHPSJ emergency room or in general medical consultation at the CMT, evolving for less than 72 hours Capable of giving free, informed and express consent Existence of underlying chronic low back pain Associated radiculalgia descending below the knee Specific low back pain (with a "red flag") Patient not reading or understanding French Patient deprived of liberty Patient under guardianship or curatorship Patient under the protection of justice
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 20.0-80.0, Colonic Polyp Colonic Adenoma In the Buddhist Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan Patients who undergo WE colonoscopy performed by the two endoscopists (YHH and CWT) at the endoscopic suite will be included Included patient declined to give consent age <20 years old age >80 years old previous partial colectomy, not completely consumed bowel prep regimen, massive ascites, or known colonic obstruction, morbid obesity (BMI ≥ 35)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Rumination Fibromyalgia Chronic Pain Repetitive Negative Thinking Adults Patients Free and informed consent signed French native speaker, writer and reader according 1990 American College of Rheumatology : Patients with diffuse pain for more than three months and with digital palpation pain on more than 11 insertion points minor patients Adult major under administrative protection Patient with severe psychosis or depression or severe anxiety or impulsivity as assessed by the clinician
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-45.0, Ectopic Pregnancy Laparoscopic Cornual Pregnancy cornual ectopic pregnancy Patients undergoing laparoscopic cornual wedge resection medical treatment area due to cornual pregnancy laparotomy conservatively managed patients
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-45.0, Pain Analgesia Labor Pain Age 18-45 ASA 1 or 2 +/-E Patient requesting epidural labor analgesia Patient in active labor (cervical change, greater than or equal to 3 cm) Good toco tracing (clearly showing contractions at least every 5 minutes) Pain score greater than or equal to 3 out of 10 with contractions History of chronic pain History of chronic opioid use BMI > 45 Allergy to sensor adhesive material, local anesthetic or opioids Contraindication to neuraxial block Patient on magnesium infusion Inability to give informed consent Severe co-morbidities
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Colorectal Cancer Patients with age more than 18 years Presenting to fast track colorectal clinic 1. With bowel symptoms 2. Presenting with anaemia 3. Rectal bleeding Any patient presenting through routine colorectal clinics 1. With bowel symptoms 2. Presenting with anaemia 3. Rectal bleeding Aged less than 18 years
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Esophagus Cancer, Adenocarcinoma Stomach Cancer, Adenocarcinoma Half of the study population in phase 2 must have a deleterious tumor alteration in at least one protocol specified gene Gastric or gastroesophageal junction adenocarcinoma Advanced stage 4 or locally unresectable stage 3 disease Must have measurable disease Must consent to have a biopsy if archival tissue is not available or not enough for molecular testing Must show evidence of progression or intolerance to at least one previous standard of care systemic therapy (not more than 2 lines of prior therapy) Patients with human epidermal growth factor receptor 2 (HER2) positive disease must show progression on prior HER2 targeted therapy Toxicities related to prior treatment should be recovered to baseline or less than grade 2 according to CTCAE Adequate organ and marrow function Absence of active autoimmune disease that has required systemic treatment in the past 2 years Prior treatment with a programmed cell death protein 1 (PD1) or programmed death- ligand 1 (PD-L1) inhibitors Prior treatment with poly-(ADP-Ribose)polymerase (PARP) Patients with microsatellite instability (MSI) high or mismatch repair (MMR) deficient tumors Abdominal fistula, GI perforation, bowel obstruction, or intra-abdominal abscess within 6 months before first dose Evidence of active peptic ulcer disease, inflammatory bowel disease, diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis, acute pancreatitis, acute obstruction of the pancreatic duct or common bile duct, or gastric outlet obstruction Inability to swallow tablets Uncontrollable ascites or pleural effusion Cavitating pulmonary lesion(s) or known endotracheal or endobronchial disease manifestation Clinically significant hematuria, hematemesis, or hemoptysis, or other history of significant bleeding within 12 weeks Lesions invading any major blood vessels
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Iliocaval Compression Syndrome acute iliocaval obstruction 2-chronic iliocaval obstruction with CEAP clinical class 3-6 3 acute on top of chronic iliocaval obstruction with CEAP clinical class 3-6 4-symptomatic acute femoro-iliocaval occlusion who underwent successful thrombolysis concomitant peripheral arterial disease in the affected limb. 2-life expectancy less than 5 years. 3 pregnancy 4 malignancy 5-raised renal chemistry 6-pelvic fibrosis 7- contraindication to anti-coagulation therapy. 8-congenital venous malformations 9-Not providing informed consent 10-Any concurrent disease as heart failure
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 5.0-15.0, Acute Appendicitis • All children between 5 and 15 years of age of both genders admitted in the pediatric surgery emergency with having PAS score >7will be included in the study Patient with suspicion of perforated appendicitis on the basis of generalized peritonitis and abscess formation on ultrasound Patients with an appendicular mass, diagnosed by clinical examination and ultrasonography Patient with previous non-operative treatment of acute appendicitis (recurrent appendicitis) Patients with C-reactive proteins > 40 mg/L Patients with history of any previous abdominal surgery
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 30.0-999.0, Acute Appendicitis in Elderly patients above age of thirty appendectomy done for them patients less than thirty years conservative mangement
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Cholecystitis Cholecystectomy Age ≥45 years; or age ≥18 years and <45 years with at least one of the following co-morbidities: diabetes or chronic respiratory, cardiovascular, or renal disease; 2. Diagnosis of acute cholecystitis defined by the presence of at least 2 of the following: 1. Abdominal pain in upper right quadrant, 2. Murphy's sign, 3. Leukocytosis >10 × 103/μl, or 4. Oral temperature <36.5°C or >38°C; 3. Cholelithiasis (stones/sludge); 4. Ultrasound signs of cholecystitis; 5. Acute cholecystitis that requires surgery and is diagnosed during working hours; 6. Expected to require at least an overnight hospital admission after surgery; and 7. Provide written informed consent to participate in FAST Patients requiring emergent surgery or emergent interventions for another reason; 2. Patients whose therapeutic anticoagulation is not reversible; 3. Patients with a history of heparin-induced thrombocytopenia and current use of warfarin with an INR ≥1.5; 4. Pregnant patients; 5. Previous participation in the trial
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Helicobacter Pylori Eradication Voluntarily signing the informed consent form; 2. Aged 18-65 years old(including 65), male or female; 3. Patients aged 35-65 years old(including 35) with positive Helicobacter pylori should undergo gastroscopy, and the gastroscopy report shows normal or chronic gastritis; 4. Patients aged 18-35 years (including 18) with positive Helicobacter pylori are not required to perform gastroscopy examination if there is no obvious clinical symptoms, or applying report of gastroscopy within 6 months showing normal or chronic gastritis Gastroscopy report or previous medical history showed significant esophagus-gastric diseases, including gastric cancer, peptic ulcer, oesophagitis and esophageal erosion; 2. Patients with chronic diarrhea and chronic functional constipation; 3. Other systemic diseases, including cardiovascular diseases, lung diseases, liver diseases (transaminase index is more than 2 times higher than the normal value), kidney diseases (creatinine index is higher than the normal value) and other important organs with severe lesions, severe metabolic diseases (diabetes, thyroid diseases), malignant tumors, and severe immune system diseases; 4. Abnormal stool routine results: fecal occult blood (+) or white blood cells (+); 5. Patients with severe psychological or mental diseases; 6. Those with a history of drug abuse or alcohol abuse; 7. Those who are allergic to the drugs in this study; 8. Those who have received Helicobacter pylori eradication therapy; 9. Drugs which affect the intestinal flora(including antibacterial drugs, microecological preparations, intestinal mucosal protectors, Chinese patent medicines, etc.) have been used in the past 1 month or need to be used continuously for more than 1 week in the experiment. 10. Pregnant or lactating women; 11. Participating or after completing other clinical trials Less than 3 months; 12. Others who researchers consider unsuitable for inclusion
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-99.0, Acupuncture Pain Range of Motion Primary pain localized to neck, shoulder, low back, hip Pain >=4 on Numeric Pain Rating Scale with one of predetermined motions Willing to participate in study and fill out questionnaires Fracture, malignancy Condition that requires urgent treatment (e.g. cervical myelopathy) Contraindications to needling (e.g. pregnancy, active infection)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 35.0-70.0, Tendinopathy Lateral hip pain, worst over the greater trochanter, present for a minimum of 3 months Age 35-70 years Female Pain at an average intensity of ≥3 out of 10 on most days of the last week Tenderness on palpation of the greater trochanter Pain on one of the following: Reproduction of pain on 30 sec single leg stand OR Positive Faber test Any known advanced hip joint pathology where groin pain is the primary complaint and/or reproduction of groin pain with Faber or Where range of pure hip joint flexion is <90° Radiating pain distal to the Gluteus Max + positive Straight Leg Raise (SLR-test < 30°) Known advanced knee pathology or restricted range of knee motion (must have minimum 90° flexion and full extension) Any systemic diseases affecting the muscular or nervous system, and uncontrolled diabetes Malignant tumour OR Systemic inflammatory disease Any factors that would preclude the participant from having an MRI (e.g. pacemaker, metal implants, pregnancy, claustrophobia) If the participant is involved in a legal/workcover or other injury claim Fear of needles (trypanophobia) If the participant is unable to write, read or comprehend Danish
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Shoulder Pain Rotator Cuff Impingement unilateral shoulder pain of more than 4 weeks duration and a Shoulder Pain and Disability Index (SPADI) score of >= 30 as this represents significant disability. Shoulder pain is defined as pain in the shoulder region, including the upper arm, elicited by active or passive shoulder movement. The diagnosis of "subacromial pain" is defined by range as no limitation in passive range of movement or restriction of passive range of movement mainly in abduction rather than external rotation inability to give informed consent physiotherapy or injection treatment for current shoulder pain in previous 3 months blood coagulation disorders bilateral shoulder pain evidence of systemic infection abnormal shoulder X-ray defined as significant glenohumeral or subacromial joint space narrowing suggesting osteoarthritis of glenohumeral joint or complete rotator cuff rupture evidence of rotator cuff tear, tested by external rotation lag sign, drop sign, internal rotation lag sign and static muscle resistance in external rotation, internal rotation and abduction history of significant trauma to the shoulder inflammatory joint disease history of cerebrovascular accident
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Trigger Point Pain, Myofascial Anyone with ribs No children
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Chronic Pain Pelvic Pain Functional Abdominal Pain Syndrome Low Back Pain Migraine Age greater than or equal to 18 years old Diagnosis of either chronic pelvic pain, functional abdominal pain, axial low back pain, or migraine with or without aura of at least 3 months duration English speaking Ability and willingness to complete questionnaires and in-person assessments Current average daily pain score of greater than or equal to 4 on the Numeric Rating Scale of Pain (0-10 scale) For patients with migraine diagnosis they must report at least 2 headaches in the baseline headache diary in the 30 days preceding randomization Any conditions causing inability to complete assessments (education, cognitive ability, mental status, medical status) Any significant psychiatric problems, including acute confusional state (delirium), ongoing psychosis, or clinically significant depression Any suicidality as assessed by answer of greater than 0 on question 9 the PHQ-9 assessing suicidal thoughts Any current illicit drug or alcohol abuse Any history of recurrent or unprovoked seizures Participation in another drug, device, or biologics trial concurrently or within the preceding 30 days Pregnancy, breast-feeding or lack of reliable contraception Changes in pain medications in the previous 4 weeks Implanted electrical stimulation device Skin infection over stimulation sites
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Appendicitis Acute Laparoscopic Surgery Patients with clinically and radiologically(Ultrasound) verified appendicitis Patients converted from laparoscopy to open surgery
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Adhesions Abdominal Adhesions Pelvic Surgery Induced Tissue Adhesions Chronic Pain In order to be eligible to participate in this study, a subject must meet all of the following Adult patients, aged above 18 years Planned for elective abdominal surgery, e.g. laparotomy or laparoscopy For phase two of this study we will recruit patients from the group that participated in phase 1. Additional for phase two Patients who developed chronic post-operative abdominal pain according to IASP Daily pain in the past three months Pain is continues or intermittent Pain scores for the worst pain are 4 or higher Or patients without chronic pain (n=100) who are propensity matched for type of surgery and risk factors for developing chronic pain A potential subject who meets any of the following will be excluded from participation in this study Mental incompetence Planned for laparoscopic cholecystectomy Planned for Caesarean section Additional for phase two are Contra-indications for MRI (without contrast) including Severe claustrophobia Metal splinters in eyes Cerebral vascular clips Electronic medical implants
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Hemorrhoids, Internal Patients referred to proctologic consultation of Centro Hospitalar Universitário do Porto (CHUP) older than 18 years Clinical diagnosis of hemorrhoidal disease grade I, II and III (Goligher's classification) Refractory to conservative management (dietary modification, intestinal transit modifiers, topical and phlebotonic medications) for a period of no less than 4 weeks Hepatic cirrhosis Pregnant or breast-feeding women Known allergy to polidocanol Another perianal disease that can cause symptoms similar to hemorrhoidal disease Concomitant presence of external hemorrhoidal disease and/or hemorrhoidal thrombosis Office-based or surgical treatment for hemorrhoids within 6 months prior to inclusion Antiplatelet or hypocoagulant medication Inherited bleeding disorders Immunosuppressive states Inflammatory bowel disease
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Appendicitis Able to give informed consent for in the study Age of the patient : Any age • Intraoperative decision to convert to open appendicectomy Primary open appendicectomy Unable to give informed consent for participation in the study
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Postoperative Pain Meet the diagnostic of grade II-IV mixed hemorrhoids and meet the operation conditions; 2. Age 18~65; 3. External stripping and internal ligation of mixed hemorrhoids, general anesthesia or lumbar shu point anesthesia; 4. VAS score ≥3 points after the implementation of analgesia pump; 5. Improve clinical auxiliary examination and sign informed consent Combined with inflammatory hemorrhoids, thrombotic hemorrhoids, perianal eczema, perianal abscess and other perianal diseases that affect the evaluation of curative effect; 2. Combined with intestinal infectious diseases, intestinal polyps, rectal malignant tumors, etc; 3. Combined with severe cardiovascular disease, immune deficiency, mental disorder, or severe liver and kidney dysfunction; 4. Auricle skin lesions or auricle skin allergy to tape is difficult to tolerate treatment; 5. Combined cognitive impairment could not complete the efficacy; evaluation; 6. Pregnancy or planned pregnancy
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, Postoperative Pain After Hemorrhoidectomy Meet the diagnostic of grade II-IV mixed hemorrhoids and meet the operation conditions; 2. Age 18~65; 3. External stripping and internal ligation of mixed hemorrhoids, general anesthesia or lumbar shu point anesthesia; 4. VAS score ≥3 points; 5. Sign informed consent Combined cognitive impairment could not complete the efficacy evaluation With other gastrointestinal conditions found during operation With severe cardiovascular, hepatic, or renal diseases With opioid addiction
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-95.0, People With Trans-femoral Amputation Unilateral transfemoral amputation or knee disarticulation ≤ K2 mobility grade OR SIGAM grade D or below; i.e. able to walk ≤ 50 meters on level ground Users of either MPK or N-MPK for at least 6 months prior to the recruitment date Not meeting
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Appendicitis Patient with the symptoms of acute appendicitis: pain in the right lower quadrant, pain migration from epigastrium to right lower quadrant, nausea, rebound pain, elevated temperature for randomized part Pregnant patient. for randomized part After primary clinical, laboratory and ultrasound examination diagnosis of acute appendicitis could not be confirmed or excluded No other gynecological, urological ir gastroenterological pathology is confirmed for randomized part Clinical symptoms lasts for longer than 48 hours Signs of peritonitis
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-70.0, Abdominal Pain Should be able to give informed consent for the study Has Enterra GES device in place for at least 2 months Continue to have moderate to severe abdominal pain on at least one pain questionnaire or >5 score (on a scale of 0-10 for pain) on the VAS questionnaire for at least 2 months Abdominal pain should be either persistent; for example, daily for at least >1 hour, be chronic for >2 months, and refractory to original Enterra GES settings Unable to provide informed consent Pregnancy Any other active health problems that would render patient unable to complete the study
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Central Nervous System Injury Neurogenic Bowel Dysfunction neurogenic bowel dysfunction secondary to acquired disease of the central nervous system Neurogenic Bowel Dysfunction Score (NBDS) between 6 and 30 previous dysfunctional conditions or organic diseases affecting the bowel tract that are pre-existing at neurological diagnosis patients with an NBDS score lower than 6 (very mild bowel dysfunction) and above 30 (very severe neurogenic bowel dysfunction) ostomy condition (ileus and colon) psychiatric patients presence of cognitive disorders female patients with proven, or even doubtful, pregnancy status
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 25.0-30.0, Dental Caries 20-25 years of age 2. No systemic diseases 3. Presence of molar / premolar teeth with occlusal and / or interface caries 4. Lack of parafunctional habits such as clenching and grinding of teeth 5. Lack of cooperation problems 6. Accepted regular visits - Any endodontic treatment or withdrawal indications (abscess, swelling and fistula complaints, palpation and percussion pain, spontaneous or night pain) 2 Teeth with congenital developmental defect 3 Teeth with pathological mobility 4 Teeth which do not have normal occlusion due to skeletal or pathological reasons 5 Lack of contact or opposite teeth
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Shoulder Pain Female patients Age: 18 years to 60 years, American Society of Anesthesiologist physical status (ASA) 1 or 2 Diagnostic or operative gynecologic laparoscopy {4 port sites, three 5 mm trocars (suprapubic, right and left iliac fossa) and one 10 mm trocar (umbilical)} between one and 3 hours duration Abdominal incisions less than 1.5 cm Steady abdominal insufflation pressure of 14 mm Hg following a gradual insufflation over a 5-minute period Insufflation at a steady maximal flow of 30 l/min Conversion to laparotomy Abdominal insufflation pressure more than 14 mm Hg Medical drug allergy to paracetamol, ketoprofen and/or tramadol Presence of gastro-esophageal reflux (GERD) Pregnancy Patient with Thrombophilias and or at high risk of Deep Vein Thrombosis (DVT) Obesity body mass index (BMI) greater than 40 One day surgery patients
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 3.0-60.0, Appendicitis Acute Patients with acute abdomen and suspected appendicitis so Obese and irritable Patients whom satisfactory graded compression US can't be done pregnant women , children under 3 years old and adults over 60 years old for radiation hazards patients with renal impairment for contrast hazards
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Tuberculosis Drug-resistant Tuberculosis Patients are eligible to be included as trial participants only if all of the following apply Aged ≥18 years Clinical suspicion of pulmonary TB including cough ≥2 weeks (or any duration if HIV positive ) and ≥1 other symptom typical of pulmonary TB listed below Fever Malaise Recent weight loss Night sweats Contact with active case Haemoptysis Chest pain Participants are excluded from the trial if any of the following apply Unwilling or unable to provide informed consent Unwilling to provide four sputum specimens at enrolment i.e. 2x sputa on day 1 and 2x sputa on day 2 (up to 1 week from enrolment) Patients with only extra-pulmonary TB signs & symptoms Receipt of any dose of TB treatment within 6 months prior to enrolment
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-75.0, Functional Gastrointestinal Disorders Participants who have symptoms of GI disturbances Participant has recurrent abdominal pain, discomfort, bloating, and/or abdominal distention associated with a change in the frequency of stool and/or a change in the form (appearance) of stool Participant is able to understand the nature and purpose of the study and provide informed consent Sexually active males and sexually active females of child-bearing potential, defined as neither surgically sterile nor post-menopausal (that is, females age >45 years and no menstrual periods for at least 1 year), must agree to use a highly effective method of contraception from Screening to 30 days post last dose of study product. Acceptable forms of contraception the following Abstinence Oral, injected, or implanted hormonal methods of contraception Intrauterine device or intrauterine contraceptive system Condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository Female whose last sexual intercourse with males was ≥6 months post-vasectomy Participant has active or a history of inflammatory bowel disease Participant has other significant systemic diseases such as active cancer therapy, active/ongoing infection, uncontrolled diabetes, chronic renal failure, cirrhosis, congestive heart failure, and severe Chronic Obstructive Pulmonary Disease (COPD) Participant has used antipsychotic medications within 3 months prior to Screening Participant has used systemic steroids within the month prior to Screening Participant has suffered from a major psychiatric disorder within the past 2 years Participant is pregnant or breastfeeding Participant has a known lactose intolerance Participant is immunocompromised or has an immunodeficiency syndrome of any kind Participant has undergone any abdominal surgery, except for hernia repair or appendectomy Participant has had active treatment with prescription medication for irritable bowel syndrome (IBS) within 6 weeks prior to Screening
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Abdominal Pain Abdominal Myofascial Pain Syndrome (AMPS) Abdominal Plane Blocks (APB) All patients aged over 18 years. 2. Chronic abdominal pain for above 6 months 3. Moderate to severe pain in the abdomen: Baseline NRS >4 (worst pain the last 24 hours) Lack of consent, including from those patients who lack mental capacity to give informed consent. 2. Patients with known history of drug allergy to depomedrone 3. Patients with infection at injection site at on day of treatment
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Gastro Intestinal Stromal Tumour I1. Male or female ≥ 18 years at the day of consenting to the study. I2. Patient must have histologically confirmed diagnosis of GIST. I3. Disease must be locally advanced or metastatic. I4. Patient who failed (disease progression and/or intolerance) previously at least to imatinib and sunitinib. Nota Bene: patients with more than 2 previous anticancer treatments are eligible. I5. Patient must have evidence of measurable disease as per the version 1.1 (Appendix 2). I6. Patient must have documented disease progression. I7. ECOG performance status 0, 1 or 2 (Appendix 3). I8. Patient must have normal organ and bone marrow function as defined below Hematologic Absolute neutrophil count (ANC) ≥ 1.5 Gi/L Haemoglobin ≥ 9 g/dl (5.6 mmol/l) (subjects may not have had a transfusion within 7 days of screening assessment) Platelets ≥ 100 Gi/l Coagulation panel Prothrombin time (PT) or international normalized ratio (INR) ≤ 1.2 X upper limit of normal (ULN) Partial thromboplastin time (PTT) ≤ 1.2 X ULN Subjects receiving anticoagulant therapy are eligible if their INR is stable and within the recommended range for the desired level of anticoagulation Hepatic Total bilirubin ≤ 1.5 X ULN E1. Patient with a documented mutation in exon 18 (D842V substitution). E2. Clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding including, but not limited to Active peptic ulcer disease Known intraluminal metastatic lesions with risk of bleeding Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), or other gastrointestinal conditions with increased risk of perforation History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior to beginning study treatment Clinically significant gastrointestinal abnormalities that may affect absorption of investigational product including, but not limited to Malabsorption syndrome Major resection of the stomach or small bowel. E3. Any active/uncontrolled infection, including known infection with HIV, Hepatitis B or Hepatitis C. E4. Corrected QT interval (QTc) > 480 msecs using Bazett's formula E5. History of any one or more of the following cardiovascular conditions within the past 6 months prior to the first dose of study drug Cardiac angioplasty or stenting Myocardial infarction
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 16.0-999.0, Acute Appendicitis all consecutive patients age ≥ 16 years, who are referred to the on-call surgeon's team with acute right iliac fossa (RIF) pain or suspected acute appendicitis, will be included history of previous appendicectomy previous abdominal surgery in the last 90 days history of chronic abdominal pathology (e.g. ovarian cyst, colitis .. etc) history of inguinal hernia pregnancy
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Appendicitis Acute Peritonitis patients admitted for appendicitis in participating centers informed patient's (or parent's for children) opposition
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Sarcoma of the Extremity Stage I Soft Tissue Sarcoma of the Trunk and Extremities Stage IA Soft Tissue Sarcoma of the Trunk and Extremities Stage IB Soft Tissue Sarcoma of the Trunk and Extremities Stage II Soft Tissue Sarcoma of the Trunk and Extremities Subjects must have a histologically confirmed diagnosis of sarcomas of the extremities (which may gluteal muscle involvement) for which neoadjuvant radiation therapy followed by surgical resection is a planned intervention Subjects whose bowel cannot be completely protected from radiation exposure due to primary tumor location (e.g., proximal lower extremity) will be excluded Subjects must have one or more measurable target lesions by version (v) 1.1, assessed via computed tomography (CT) scan or magnetic resonance imaging (MRI) At the time of study enrollment, subjects must have a tumor burden that is judged to be surgically resectable Absolute neutrophil count (ANC) >= 1500/mm^3 (>= 1.5 GI/L) without granulocyte colony-stimulating factor support in the last 28 days White blood cell count >= 2500/mm^3 (>= 2.5 GI/L) Platelets >= 100,000/mm^3 (>=100 GI/L) without transfusion in the last 28 days Hemoglobin >= 9 g/dL (>= 90 g/L) without transfusion in the last 28 days Alanine aminotransferase (ALT), aspartate aminotransferase (AST) =< 3 X upper limit of normal (ULN) Alkaline phosphatase (ALP) =< 3 X upper limit of normal (ULN) Receipt of any type of cytotoxic, biologic or other systemic anticancer therapy (including investigational) for the investigational diagnosis Receipt of any prior radiation therapy for the investigational diagnosis Known central nervous system (CNS) metastases Concomitant anticoagulation with oral anticoagulants(e.g., warfarin, direct thrombin and factor Xa inhibitors) or platelet inhibitors (e.g., clopidogrel). Allowed anticoagulants are the following Low-dose aspirin for cardioprotection (per local applicable guidelines) is permitted Low-dose low molecular weight heparins (LMWH) are permitted Anticoagulation with therapeutic doses of LMWH is allowed in subjects without known brain metastases who are on a stable dose of LMWH for at least 6 weeks before first dose of study treatment, and who have had no clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor. Subjects with hemoptysis, central nervous system hemorrhage or gastrointestinal hemorrhage within the last 6 months prior to treatment are excluded The subject has uncontrolled, significant intercurrent or recent illness including, but not limited to, the following conditions Cardiovascular disorders Congestive heart failure New York Heart Association Class 3 or 4, unstable angina pectoris, serious cardiac arrhythmias
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Hernia, Ventral Seroma as Procedural Complication Patients planned for laparoscopic ventral hernia repair Defect size 3-10 cm BMI <40 Defect size >10 cm Ventral hernias with other localization than the midline Emergency surgery and incarcerated hernias Preoperative anticipation of extensive adhesions Pregnancy or intended pregnancy Serious comorbidity (ASA score >3)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-85.0, Painful Diabetic Peripheral Neuropathy Female and male patients aged 18-85 years. 2. Patients with a history of type 2 diabetes mellitus according to The American Diabetes Association (ADA). 3. Patients with a diagnosis of painful diabetic peripheral neuropathy (PDPN) caused by type 2 diabetes mellitus based on DN4 ≥4. 4. Patients whose average pain intensity in PDPN in last 24 hours (measured by VAS), evaluated on baseline visit, is equal or more than 40 mm (0 mm ='no pain' and 100 mm ='worst possible pain'). 5. Ability to adhere to trial protocol. 6. Written informed consent. The methods for assessment medical history, interview, completing the DN4 questionnaire, physical examination, assesment of pain on VAS and laboratory analyses Patients who took PDPN medication and/or analgesics on a day of baseline visit. 2. Patients with a known hypersensitivity to duloxetine, pregabalin, paracetamol or tramadol or any of the inactive ingredients or have any contraindication for the use of duloxetine, pregabalin, paracetamol or tramadol. 3. Patients with a history of inadequate pain response (pain reduced was equal or less than 30%) to: 3.1. pregabalin at maximum allowed treatment daily dose 600 mg, 3.2. duloxetine at maximum allowed treatment daily dose 120 mg, 3.3. venlafaxine at maximum allowed treatment daily dose 375 mg, 3.4. gabapentin on daily treatment dose more than 1800 mg 3.5. amitriptilin at maximum allowed treatment daily dose 150 mg. 4. Patients, who are currently treated with a daily dose that exceeds: 4.1. 150 mg of pregabalin, 4.2. 60 mg of duloxetine, 4.3. 150 mg of venlafaxine, 4.4. 600 mg of gabapentin. 5. Patients with an uncontrolled type 2 diabetes mellitus. 6. The average scores of less than 20 on MoCA. 7. Have any other type of neuropatic pain, contrasted to PDPN. 8. Evidence of another cause of distal polyneuropathy other than diabetic. 9. Have a serious (evaluated by physician) unstable cardiovascular (e.g. uncontrolled hypertension), hepatic, renal, respiratory, ophthalmologic, gastrointestinal, or hematologic illness, symptomatic peripheral vascular disease, malignant disease or other medical condition that could lead to hospitalisation during the course of the trial. 10. Have a diagnosis or history of uncontrolled glaucoma. 11. Known or suspected alcohol or drug abuse or addiction (excluding nicotine and caffeine). 12. Patients with a history of depression (less than one year after completing the last medical treatment), mania, bipolar disorder, psychosis or schizophrenia. 13. Pregnancy, lactation and women of child-bearing potential without highly effective* or at least acceptable** contraception (according to the Recommendations related to contraception and pregnancy testing in clinical trials). 14. Patients with a history of epilepsy, stroke or neurodegenerative disease. 15. Patients taking Monoamine oxidase (MAO) inhibitors or are within one year of their withdrawal. 16. Acute liver injury (such as hepatitis) or severe cirrhosis (Child-Pugh Class C). 17. Patients with suspected Restless leg syndrome (RLS). 18. Abnormal thyroid-stimulating hormone (TSH) concentrations (according to the references value of the local laboratory). 19. Vitamin B12 and folic acid deficiency (according to the reference values of the local laboratory). 20. Surgical procedures planned to occur during trial (patients may be rescreened following completion of and recovery from the surgical procedure). 21. Concomitant treatment that might influence the final therapeutic effect of the tested active substances including non-medical treatments. 22. Patients who under the opinion of the investigator will not be compliant to the treatment or not be able to finish the trial for any other reason Highly effective contraception is combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation(oral, intravaginal, transdermal) progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, implantable) intrauterine device (IUD) intrauterine hormone-releasing system (IUS) bilateral tubal occlusion vasectomised partner sexual abstinence **Acceptable contraception is progestogen-only oral hormonal contraception, where inhibition of ovulation is not the primary mode of action
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Contrast Media Comfort Temperature Abdomen Patients referred for abdominal CT Patient ≥ 18 years old and competent to sign informed consent Hemodynamic instability Pregnancy Renal insufficiency defined as glomerular filtration rate (GFR) < 30ml/min/1.73m2 (Odin protocol 004720) Iodine allergy (Odin protocol 022199) Age < 18 year Unable to give informed consent or no informed consent obtained Inability to position an 18 gauge cannula in an antecubital vein
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Perforated Appendicitis Men and women of all ages Clinical and radiological diagnosis by contrast CT scan of acute perforated appendicitis Formal consent for the present study must be signed by the patient or his/her parents Patients with initial presentation of a phlegmon (abscess in evolution) Patients with non-perforated appendicitis Presentation with initially non-perforated appendicitis but found perforation at surgery Patient with septic shock Patients who had previous appendectomy Current treatment of malignancy Immunocompromised patients Positive pregnancy test No consent for the study
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 19.0-999.0, Abdominal Pain Patient presenting to the MGH Emergency Department with abdominal pain English-speaking Known to be pregnant Patients with altered mental status Patients who are critically ill or unstable
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 5.0-9.0, Deep Caries Previously untreated, vital and asymptomatic lower primary molars with deep caries lesions considered likely to result in pulp exposure if they were treated by a single and terminal excavation Positive pulp sensibility tested by an electric pulp tester and cold stimulation Mild discomfort from chemical and thermal stimuli Cooperative children and parents willing to follow the instructions and report for follow-up Signs of irreversible pulpitis (spontaneous pain, prolonged pain response etc.) The presence of percussion or palpation sensitivity, pathological mobility, or infection symptoms like fistula or abscess or discoloration in the clinical examination Absence of normal lamina dura and periodontal range, presence of lesion, internal or external resorption or calcification in or around the root in the radiological examination Children with special health care needs
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 14.0-80.0, Appendicitis Age: more than 14years of both sexes Non pregnant female Patients taking analgesics. .Patients who diagnosed to have grey zone diagnosis of acute appendicitis (Alvarado score 5-6) Alvarado score >6 or < 5 Cases of sure acute appendicitis Documented Liver disease, biliary disease (congenital or acquired), hemolytic diseases and history of alcoholism. 4) Cases revealed other pathology than appendicitis by CT and laparoscopy
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Critical Limb Ischemia Patients with a diagnosis of critical ischemia of the lower limb with severe pain and side effects of opioids Under 18 years old
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-70.0, Acute Appendicitis Adult patients emergency admitted for suspected acute appendicitis 2. Age 18 3. Computed Tomography of the abdomen with contrast confirmed uncomplicated appendicitis, as evidenced by presence of a dilated, thickened wall appendix without perforation, abscess or gangrene History of previous appendicitis 2. Evidence of perforation, abscess or gangrene of appendix on CT scan 3. Significant paralytic ileus as evidenced by dilated bowel loops on imaging 4. Evidence of co-existing acute surgical pathologies on the CT scan 5. Allergic to bowel preparation solution (Polyethylene glycol) 6. Marked electrolyte abnormalities, significant renal impairment (CrCl <30ml/min) 7. Coagulopathy (INR >1.5, platelet <50) 8. Pregnancy, or contraindication to fluoroscopy 9. Other cases deemed by the examining physician as unsuitable for safe treatment 10. Refusal to participate
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-80.0, Surgical Site Infection Brain Tumor Patients with American Society of Anesthesiologists score I-II-III Surgical intervention planned with the diagnosis of brain tumor No systemic infection such as sepsis, pneumonia, blood infections, or intracranial infection such as meningitis, abscess or local infection Not having a mental illness Being morbidly obese (BMI> 40kg / m2) Immune deficiency Using immunosuppressive drugs Being addicted to alcohol and substances Having received radiotherapy and / or chemotherapy before surgery Having the disease that requires infective endocarditis prophylaxis (Rheumatic valve diseases, prosthetic heart valves, previous endocarditis, etc.) Corruption of cranium integrity and emergency surgery planned Having systemic or intracranial infections Transfenoidal surgery intervention planned Using implants during surgical intervention
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-22.0, Acute Myeloid Leukemia All patients must be enrolled on APEC14B1 and consented to Screening (Part A) prior to enrollment and treatment on AAML1831. Submission of diagnostic specimens must be done according to the Manual of Procedures). Risk stratification will not be possible without the submission of viable samples. Given there are multiple required samples, bone marrow acquisition techniques such as frequent repositioning or performing bilateral bone marrow testing should be considered to avoid insufficient material for required studies. Consider a repeat marrow prior to starting treatment if there is insufficient diagnostic material for the required studies Patients must be less than 22 years of age at the time of study enrollment Patient must be newly diagnosed with de novo AML according to the 2016 World Health Organization (WHO) classification with or without extramedullary disease Patient must have 1 of the following >= 20% bone marrow blasts (obtained within 14 days prior to enrollment) In cases where extensive fibrosis may result in a dry tap, blast count can be obtained from touch imprints or estimated from an adequate bone marrow core biopsy < 20% bone marrow blasts with one or more of the genetic abnormalities (sample obtained within 14 days prior to enrollment) A complete blood count (CBC) documenting the presence of at least 1,000/uL (i.e., a white blood cell [WBC] count >= 10,000/uL with >= 10% blasts or a WBC count of >= 5,000/uL with >= 20% blasts) circulating leukemic cells (blasts) if a bone marrow aspirate or biopsy cannot be performed (performed within 7 days prior to enrollment) ARM C: Patient must be >= 2 years of age at the time of Late Callback ARM C: Patient must have FLT3/ITD allelic ratio > 0.1 as reported by Molecular Oncology Patients with myeloid neoplasms with germline predisposition are not eligible Fanconi anemia Shwachman Diamond syndrome Patients with constitutional trisomy 21 or with constitutional mosaicism of trisomy 21 Any other known bone marrow failure syndrome Any concurrent malignancy Juvenile myelomonocytic leukemia (JMML) Philadelphia chromosome positive AML Mixed phenotype acute leukemia Acute promyelocytic leukemia
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Right-sided Colon Cancer Right-sided Colon Adenoma for track 1 and 2a Male and female patients above 18 years of age with either: right-sided colon cancer tumor with adenocarcinoma histologically verified scheduled for open or laparoscopic resection at the Department of Surgery, Herlev Hospital or Zealand University Hospital for track 1. Right-sided adenomas ≥2cm in diameter endoscopically verified scheduled for endoscopic mucosal resection at the Department of Surgery, Herlev Hospital or Zealand University Hospital for track 2a ASA I,II or III The caecum must be reached by the endoscope. for retrospective controls (track 2b): Male and female patients above 18 years of age who were operated for colon adenoma ≥2cm in diameter in the right hemicolon in 2018 at Department of Surgery, Zealand University Hospital. They will be matched 2:1 with the patients included in track 2a (cases) based on age and gender and pathology of the tumor for track 1 and track 2a 1. Patients with previous allergic reaction to fosfomycin and/or metronidazole 2. Patients under current antibiotic treatment or patient who had the last dose of antibiotics 30 days prior to inclusion. 3. Patients with a non-passable tumor or patients where a part of the tumor is not visible during endoscopy (Track 1) 4. Patients with neoadjuvant chemotherapy or radiation 12 months prior to the resection. 5. Patients with a history of familial adenomatous polyposis (FAP) or hereditary nonpolyposis colorectal cancer (HNPCC) 6. Patients with a history of inflammatory bowel disease (IBD) 7. Patients under current treatment with warfarin (Marevan) and phenprocoumon (Marcoumar), or NOAK such as dabigatran (Pradaxa®), rivaroxiban (Xarelto®), edoxaban (Lixiana®) or apixaban (Eliquis®) 8. Patients under current treatment with Fenemal (Phenobarbital) 9. Patients who previously have received a fecal transplantation 10. Patients who have previously had colorectal cancer, and are now presenting with a secondary colon tumor. 11. Patients with a current alcohol use disorder (AUD): defined as a patient who are currently drinking 8 or more drinks/week for women and 15 or more drinks/week for men. 12. Predictable poor compliance (psychiatric disease, not speaking fluent Danish, mentally, impaired etc) 13. Patients with an American Society of Anaesthesiologists physical status 14. Classification (ASAscore) of IV. 15. Patients unable to be sedated 16. Pregnancy or lactation (fertile women must have a negative serum or urine pregnancy test to participate) 17. Fertile women who do not use safe contraception during the study period 18. Following contraceptive methods are acceptable when used consistently and in accordance, with both the product label and the instructions of the physician are Oral contraceptive, either combined or progestogen alone Injectable progestogen Implants of levonorgestrel Estrogenic vaginal ring Percutaneous contraceptive patches Intrauterine device or intrauterine system with a documented failure rate < 1% per year Male partner sterilization (vasectomy with documented azoospermia) prior to female patient ́s entry into the study, and this male is the sole partner for that patient Double barrier method: condom with spermicidal agent (foam/gel/film/cream/suppository), condom and occlusive cap (diaphragm or cervical/vault cap) with vaginal spermicidal agent (foam/gel/film/cream/suppository) for retrospective controls (track 2b)
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-40.0, Hydrosalpinx primary or secondary infertility cases unilateral or bilateral hydrosalpinx proved by HSG (hystersalpingogram) or by TVUS(transvaginal ultrasound) Uterine factor of infertility male factor of infertility preexisting ovarian pathology Presence of septic focus medical or surgical conditions that contraindicated pregnancy
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Appendicitis Acute appendicitis where surgery is planned. Diagnosis of appendicitis should be verified either by clinical diagnosis with Adult Appendicitis Score >=16 or by diagnostic imaging (CT-scan, MRI or ultrasound) showing appendicitis. All patients with symptoms at least 3 days should undergo diagnostic imaging before inclusion Complicated appendicitis according to diagnostic imaging. The following findings indicate complicated appendicitis: extraluminal air or extraluminal fecalith; fluid collection, abscess or phlegmon next to appendix; non-enhancement appendiceal wall on contrast enhanced CT-scan Plasma C-reactive protein >=100 Fever measured on emergency department over 38.5 degrees Celcius Clinical generalized peritonitis or other reason that indicate immediate surgery Pregnancy, pregnancy test is taken from all fertile aged women before randomization Allergy to study antibiotics, or anaphylactic reaction after betalactam antibiotic or other contraindication for metronidazole or ongoing antibiotic treatment or patient is carrier of resistant bacteria. (This are applicable only on randomization into antibiotic treatment arms) Missing written informed consent
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Pancreatitis Patients age greater or equal to 18 presenting to one of the collaborating centers Diagnosis of acute pancreatitis according to the revised Atlanta classification which requires 2 of the following 3 A) Typical abdominal pain; B) Increase in serum amylase or lipase levels higher than 3 times the upper limit of normality; and C) Signs of AP in imaging Uncontrolled arterial hypertension (systolic blood pressure >180 and/or diastolic blood pressure 100 mmHg) New York Heart Association Class II hear failure (slight limitation of physical activity; fatigue, palpitations or dyspnea with ordinal physical activity) or worse, or ejection fraction<50% in the last echocardiography Decompensated cirrhosis (Child's Class B or C) Hyper or hyponatremia (<135 or >145 mEq/l) Hyperkalemia (>5 mEq/l) Hypercalcemia (albumin or protein-corrected calcium>10.5 mg/dl) Chronic kidney failure (basal glomerular filtration rate <60 mL/min/1.73m2) Clinical signs or symptoms of volume overload or heart failure at recruitment (dyspnea, peripheral edema, pulmonary rales, or evident increased jugular ingurgitation at 45º) Shock or respiratory failure according to the revised Atlanta classification at recruitment (non-fluid responding systolic blood pressure< 90 mmHg, PaO2/FIO2≤300 mmHg) Time from pain onset to arrival to emergency room >24h
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-100.0, Acute Appendicitis diagnosis of acute appendicitis Performing laparoscopic surgery Patients with an ASA score of I-II-III Appendectomies with the patient's refusal to participate in the study Open surgery Primary pathology without appendicitis
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-65.0, to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs postoperative nausea and vomiting systemic disease as diabetes or hypertension local gastric diseases
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Ventral Hernia Patient with incisional midline ventral hernia (M2: epigastric, M3: umbilical, M4: infra-umbilical) with a minimal width of 3 cm and a maximum width of 8 cm. Multiple hernia defects (Swiss cheese) are allowed according to European Hernia Society (EHS) classification (Appendix 1). 2. Recurrences are only allowed to be included after former primary repair (suture repair without mesh). 3. Patients with ASA grade I to III. 4. Patient is at least 18 years old. 5. Patient must sign and date the informed consent form prior to treatment. 6. Patient is able to tolerate general anesthesia Patient with a life expectancy of less than 2 years. 2. Patient is suspected of being unable to comply with the study protocol. 3. Patient is pregnant. 4. Patient needs acute surgery. 5. Patient is enrolled in another study
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-999.0, Acute Appendicitis Age >18 years Patients diagnosed as acute appenditicitis cases according to clinical (preoperative and peroperative) and preoperative laboratory findings and imaging modalities (ultrasound, computed tomography), and pathologic results Patients who were operated by the same surgical team of the Kahramanmaras Sutcu Imam University Hospital Patients younger than 18 years Negative appendectomies according to peroperative findings and pathologic findins Patients whose data were not available Patients who were operated by the other surgical team of the Kahramanmaras Sutcu Imam University
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 16.0-999.0, Perforated Appendicitis Covid19 patients with acute appendicitis older than 16 years appendectomy in time frame 16th of march to 30th of May in the Years 2018, 2019 and 2020 patients with acute appendicitis younger than 16 years appendectomy not in the named time frames
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 21.0-60.0, Gynecologic Disease Patient acceptance BMI ≤35 kg/m2 ASA I and ASA II Scheduled for elective laparoscopic gynecologic surgeries for benign lesions under general anesthesia Patients with pre-existing chronic pain disorders Patients on opioid or sedative use Psychological and mental disorders Severe hypertensive, cardiac, hepatic and renal patients
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 0.0-999.0, Catastrophization Chronic Pain Pain, Chronic Cognitive Therapy Smartphones Acceptance, Social The for patients in this study were: patients ≥18 years of age presenting pain of any location, lasting ≥ 3 months, intensity ≥ 4 on the EVN (Numerical Visual Scale), and with one of the following characteristics: Continuous pain, Intermittent pain ≥ 5 days a week. Not be participating in another research project and with skills for the use of mobile telephony included cancer patients, bipolar or psychotic disorder, a history of brain injury, inability to complete study forms due to mental disability or language barrier
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0
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 13.0-70.0, Perforated Appendicitis Patients between the age 13 and 70 years 2. Diagnosed with perforated appendicitis intra-operatively 3. Undergo open appendicectomy via Lanz incision Surgical technique: Laparoscopic appendicectomy or mid-line laparotomy 2. Patients on steroid treatment and immunosuppressant therapy
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-100.0, Acute Appendicitis Patients with suspected acute appendicitis and scanned by diffusion weighted magnetic resonance imaging Patients evaluated by CT younger than 18 years
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1
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-60.0, Appendicitis Other and Unspecified Acute Appendicitis Acute Disease Gastrointestinal Disease Intra-abdominal Infection Age 18-60 years Clinical suspicion of acute uncomplicated appendicitis based on history, physical examination, laboratory findings evaluated by a senior surgeon Body mass index over 30 kg/m2 Age <18 years or > 60 years Pregnancy or breastfeeding Allergy to contrast material or iodine History of appendectomy Renal failure, creatinine-value greater than the upper reference value Diabetes mellitus and metformin medication Suspicion of peritonitis and appendiceal perforation Incapability to cooperate and give consent to participate in the study
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2
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The patient is a 31-year-old woman complaining of abdominal pain. The pain started last night as diffuse abdominal discomfort. She had poor appetite as well as malaise. The pain worsened in intensity and became sharp in the morning. The pain became localized to the right lower quadrant in the morning. The temperature is within the normal limits with normal vital signs. Focal tenderness and guarding were observed during palpation of the right lower quadrant. Palpation of the left lower quadrant causes pain on the right. Her lab work is remarkable for leukocytosis. Computed Tomography of the abdomen with contrast shows the presence of a distended appendix with thickened appendiceal wall without perforation, abscess or gangrene. She is a candidate for laparoscopic appendectomy under general anesthesia.
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eligible ages (years): 18.0-85.0, Low Back Pain, Recurrent Neuropathic Pain Facet Joint Pain Central Sensitisation Aberrant Neuronal Branching Nociceptive Pain Mechanical Low Back Pain patients with chronic lumbar back pain supposed to be of facet joint origin (low back pain irradiated to buttocks, legs, eventually feet in absence of positivity to FJ provocative clinical tests, possible muscle spasm over the affected joints positivity to DN4 assessment in the NPPG + negative MBB and negative DN4 assessment + positive MMB in the NMPG efficacy of MBDR-RF treatment for at least one time reported in the personal clinical history, unresponsive to the last CRF or WCRF (only for the NPPG) an MRI no more than 2 years basal NRS ≥ 7 patients between 18y and 85y ASA (American Society of Anaesthesiologists scale) I-III absence of severe chronic disease associated, full mental capacity to sign the informed consent. This group is well aware that nowadays literature lack of confirmed clinical diagnostic like underlined in the last CPG-ASRAPM. Despite this issue, we decided to select our clinical to better identify LBP of FJ origin following some of the indications mentioned in the Delphi survey of an expert panel (Wilde et al., 2007) reproduction of similar or even worsening of basal pain during paravertebral finger pressure applied no more than 2-3 cm laterally to the midline (89% expert acceptance) improvement of patient's pain during the flexion of the trunk while sitting (78% expert acceptance)
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0
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