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values | reasoning_free_pred stringclasses 0
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|---|---|---|---|---|---|---|---|---|
Does neurobehavioral disinhibition predict initiation of substance use in children with prenatal cocaine exposure? | [
"In previous work we (Fisher et al., 2011) examined the emergence of neurobehavioral disinhibition (ND) in adolescents with prenatal substance exposure. We computed ND factor scores at three age points (8/9, 11 and 13/14 years) and found that both prenatal substance exposure and early adversity predicted ND. The pu... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Caregivers",
"Child",
"Child Abuse",
"Child Behavior Disorders",
"Cocaine",
"Depression",
"Domestic Violence",
"Female",
"Humans",
"Inhibition (Psychology)",
"Longitudinal Studies",
"Marijuana Abuse",
"Pregnancy",
"Prenatal Exposure Delayed Effects",
"Proporti... | null | null | null | yes | Prenatal drug exposure appears to be a risk pathway to ND, which by 8/9 years portends substance use initiation. |
Is subclinical Atherosclerosis Accelerated in Patients with Ankylosing Spondylitis with Low Disease Activity : New Data and Metaanalysis of Published Studies? | [
"Chronic inflammatory rheumatic diseases are associated with accelerated atherosclerosis, but data in ankylosing spondylitis (AS) are limited and the relative contribution of inflammation versus classical cardiovascular (CV) risk factors remains a matter of controversy. We addressed this in an original study and a ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [] | null | null | null | no | Low AS disease activity is not associated with accelerated atherosclerosis. |
Is heart failure with preserved ejection fraction characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency? | [
"We sought to evaluate the role of exercise-related changes in left ventricular (LV) relaxation and of LV contractile function and vasculoventricular coupling (VVC) in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and to assess myocardial energetic status in these patients.",
"To d... | [
"OBJECTIVE",
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Aged",
"Case-Control Studies",
"Energy Metabolism",
"Exercise",
"Female",
"Heart Failure",
"Humans",
"Male",
"Middle Aged",
"Myocardial Contraction",
"Stroke Volume",
"Ventricular Dysfunction, Left"
] | null | null | null | yes | Patients with HFpEF have reduced cardiac energetic reserve that may underlie marked dynamic slowing of LV active relaxation and abnormal VVC during exercise. |
Is soluble ( Pro ) Renin Receptor a predictor of gestational diabetes mellitus? | [
"Gestational diabetes mellitus (GDM) is a common endocrine complication in pregnancy. While it has been established that age, family history of diabetes, insulin resistance and several biomarkers are associated with GDM but significant gaps remain in understanding risk factors for GDM. Soluble pro-renin receptor (s... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Biomarkers",
"Diabetes, Gestational",
"Female",
"Glucose Tolerance Test",
"Humans",
"Insulin Resistance",
"Iran",
"Logistic Models",
"Pregnancy",
"Pregnancy Complications",
"Pregnancy Trimester, First",
"ROC Curve",
"Receptors, Cell Surface",
"Risk Factors",
"Sensitivity and ... | null | null | null | yes | Increased level of s (pro)RR in first trimester may be a marker for predicting GDM. |
Does obvious emphysema on computed tomography during an acute exacerbation of chronic obstructive pulmonary disease predict a poor prognosis? | [
"Emphysematous change on computed tomography (CT) during the stable phase of chronic obstructive pulmonary disease (COPD) is reported to correlate with COPD prognosis. Acute exacerbation of COPD (AECOPD) is associated with a high risk of mortality and a poor prognosis.",
"This study aims to study the relationship... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Acute Disease",
"Aged",
"China",
"Female",
"Follow-Up Studies",
"Humans",
"Lung",
"Male",
"Predictive Value of Tests",
"Prognosis",
"Prospective Studies",
"Pulmonary Disease, Chronic Obstructive",
"Pulmonary Emphysema",
"Survival Rate",
"Tomography, X-Ray Computed"
] | null | null | null | yes | Obvious emphysematous changes on CT (LAA% > 7.5%) during an AECOPD predicts a poor prognosis independent of other known indicators. |
Are chemokine expression patterns in the systemic and genital tract compartments associated with HIV-1 infection in women from Benin? | [
"Understanding the genital mucosal immunity and the factors involved in linking innate to adaptive immunity is crucial for the design of efficient preventive strategies against human immunodeficiency virus (HIV)-1.",
"Levels of both genital mucosal and blood chemokines were compared between 58 HIV-1-uninfected an... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Benin",
"Cells, Cultured",
"Chemokine CCL3",
"Chemokine CCL4",
"Chemokine CCL7",
"Chemokine CXCL9",
"Female",
"Gene Expression Regulation",
"Genitalia, Female",
"HIV Infections",
"HIV-1",
"Humans",
"Immunity, Mucosal",
"Occupational Exposure",
"Risk Factors"
] | null | null | null | yes | Increased production of chemokines in the genital tract may favour the recruitment of HIV-1 target cells causing a mucosal environment that promotes viral replication and dissemination, whereas higher expression of beta-chemokines at the systemic level is associated with protection from HIV-1 infection. |
Does [ Pathological observation of lung injury in experimental animals induced by non-ferrous metal ( tin ) dust ]? | [
"To explore the characters of lung injury induced by tin dusts and to provide the diagnosis evidence of tin pneumoconiosis.",
"Forty SD rats were randomly divided into four groups: the group exposed to tin dusts from smelting workshop, the group exposed to tin dusts from tin refining workshop, the positive contro... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Dust",
"Lung",
"Lung Injury",
"Rats",
"Rats, Sprague-Dawley",
"Tin"
] | null | null | null | yes | Non-ferrous metal tin dusts can induce the specific lung injury (granuloma formation) in lung tissue of rats exposed to tin dusts, which fulfilled the diagnostic criteria of specific pathological changes in early tin pneumoconiosis. |
Is dNA methylation of genes linked with retinoid signaling in gastric carcinoma : expression of the retinoid acid receptor beta , cellular retinol-binding protein 1 , and tazarotene-induced gene 1 genes associated with DNA methylation? | [
"Hypermethylation of CpG islands has been associated with silencing of various tumor suppressor genes, and the retinoid acid receptor beta (RARbeta), cellular retinol-binding protein 1 (CRBP1), and tazarotene-induced gene 1 (TIG1) genes have been associated with retinoic acid signaling. To the authors' knowledge, l... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adenocarcinoma",
"Adult",
"Aged",
"Aged, 80 and over",
"Azacitidine",
"Carcinoma, Adenosquamous",
"DNA Methylation",
"Female",
"Gastric Mucosa",
"Gene Expression Regulation, Neoplastic",
"Gene Silencing",
"Genes, Tumor Suppressor",
"Humans",
"Intestinal Neoplasms",
"Male",
"Membrane P... | null | null | null | yes | The results suggested that gastric carcinogenesis involves transcriptional inactivation by aberrant DNA methylation of genes related to retinoid signaling. |
Does antiangiogenic therapy of cerebral melanoma metastases result in sustained tumor progression via vessel co-option? | [
"In the brain, tumors may grow without inducing angiogenesis, via co-option of the dense pre-existent capillary bed. The purpose of this study was to investigate how this phenomenon influences the outcome of antiangiogenic therapy.",
"Mice carrying brain metastases of the human, highly angiogenic melanoma cell li... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Angiogenesis Inhibitors",
"Animals",
"Brain",
"Brain Neoplasms",
"Cell Line, Tumor",
"Disease Progression",
"Humans",
"Immunohistochemistry",
"Magnetic Resonance Imaging",
"Male",
"Melanoma",
"Mice",
"Mice, Inbred BALB C",
"Necrosis",
"Neoplasm Metastasis",
"Neovascularization, Pathol... | null | null | null | yes | Our data show that, although angiogenesis can be effectively blocked by ZD6474, in vessel-dense organs this may result in sustained tumor progression via co-option, rather than in tumor dormancy. Importantly, blocking VEGF-A may result in undetectability of tumors in CE-MRI scans, leading to erroneous conclusions about therapeutic efficacy during magnetic resonance imaging follow-up. The maintenance of VEGF-A-induced vessel leakage in the absence of neovascularization at lower ZD6474 doses may be exploited to improve delivery of chemotherapeutic agents in combined treatment regimens of antiangiogenic and chemotherapeutic compounds. |
Do clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages? | [
"The extract and essential oil of clove (Syzygium aromaticum) are widely used because of their medicinal properties. Eugenol is the most important component of clove, showing several biological properties. Herein we have analysed the immunomodulatory/anti-inflammatory effect of clove and eugenol on cytokine product... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Anti-Inflammatory Agents",
"Cytokines",
"Dose-Response Relationship, Drug",
"Drug Administration Schedule",
"Enzyme-Linked Immunosorbent Assay",
"Eugenol",
"Immunologic Factors",
"Lipopolysaccharides",
"Macrophages, Peritoneal",
"Male",
"Mice",
"Mice, Inbred BALB C",
"Oils, Vol... | null | null | null | yes | Clove exerted immunomodulatory/anti-inflammatory effects by inhibiting LPS action. A possible mechanism of action probably involved the suppression of the nuclear factor-κB pathway by eugenol, since it was the major compound found in clove extract. |
Does pretreatment with stellate ganglion blockade before ischemia reduce infarct size in rat hearts? | [
"To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury.",
"This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats we... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Ischemic Preconditioning, Myocardial",
"Male",
"Myocardial Infarction",
"Rats",
"Rats, Sprague-Dawley",
"Stellate Ganglion"
] | null | null | null | yes | Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2. |
Does lipidomics reveal multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice? | [
"Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparatio... | [
"BACKGROUND",
"RESULTS"
] | [
"3T3-L1 Cells",
"Adipocytes",
"Animals",
"Anticholesteremic Agents",
"Apolipoprotein E3",
"Biochemistry",
"Body Weight",
"Cholesterol Ester Transfer Proteins",
"Drug Evaluation, Preclinical",
"Drugs, Chinese Herbal",
"Female",
"Lipid Metabolism",
"Lipids",
"Metabolic Networks and Pathways"... | null | null | null | yes | SUB885C, a multi-components preparation, is able to produce anti-atherogenic changes in lipids of the ApoE*3Leiden.CETP mice, which are comparable to those obtained with compounds belonging to known drugs (e.g. rimonabant, atorvastatin, niacin). This study successfully illustrated the power of lipidomics in unraveling intervention effects and to help finding new targets or ingredients for lifestyle-related metabolic abnormality. |
Is elevated nm23 protein expression correlated with diminished progression-free survival in patients with epithelial ovarian carcinoma? | [
"The role of the candidate metastasis-suppressor gene nm23-H1 first characterized in breast cancer remains controversial, with both metastasis suppression and disease progression being linked to elevated nm23-H1 gene expression in different human tumor types. We sought to characterize (1) the pattern and intensity ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Carcinoma",
"Cohort Studies",
"Disease Progression",
"Female",
"Humans",
"Immunohistochemistry",
"Middle Aged",
"Monomeric GTP-Binding Proteins",
"NM23 Nucleoside Diphosphate Kinases",
"Neoplasm Staging",
"Nucleoside-Diphosphate Kinase",
"Ovarian Neoplasms... | null | null | null | yes | Expression of nm23-H1/NDP kinase is strongly upregulated in most EOCs. Redundant overexpression of nm23-H1/NDP kinase may contribute to deranged cell cycle progression and EOC proliferation. Pattern and intensity of nm23-H1/NDP kinase immunostaining of EOC tissue retrieved at primary operation may identify patients at risk for tumor progression and help guide treatment strategies. These findings suggest that nm23-H1 gene expression may have distinct if not opposite biologic functions in EOC and breast carcinoma. |
Does leukotriene B ( 4 ) enhance tumour necrosis factor-alpha-induced CCL27 production in human keratinocytes? | [
"A chemokine CCL27 recruits skin-homing T cells. CCL27 production by epidermal keratinocytes is dependent on nuclear factor-kappaB (NF-kappaB) activity and is enhanced in lesions with atopic dermatitis or allergic contact dermatitis. A lipid mediator leukotriene B(4) (LTB(4)) may be involved in the development of t... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Cells, Cultured",
"Chemokine CCL27",
"Chemokines, CC",
"Extracellular Signal-Regulated MAP Kinases",
"GTP-Binding Protein alpha Subunits, Gi-Go",
"Humans",
"I-kappa B Proteins",
"Keratinocytes",
"Leukotriene B4",
"MAP Kinase Kinase Kinases",
"NF-KappaB Inhibitor alpha",
"Phosphatidylinositol ... | null | null | null | yes | These results suggest that LTB(4) may enhance TNF-alpha-induced CCL27 production by activating NF-kappaB via the BLT1/G(i/o)/PI3K/ERK pathway in human keratinocytes. LTB(4) may contribute to the enhanced CCL27 production of keratinocytes in lesions with atopic dermatitis or allergic contact dermatitis. |
Do hemoglobin levels predict biochemical outcome for localized prostate cancer treated with neoadjuvant androgen-suppression therapy and external-beam radiotherapy? | [
"To investigate whether hemoglobin (Hb) levels affect outcome in men with localized prostate adenocarcinoma (LPA) treated with neoadjuvant androgen-suppression therapy (NAST) and external-beam radiotherapy (EBRT).",
"A total of 563 men with LPA treated with NAST (median: 5.3 months) and EBRT who had Hb levels dur... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Aged, 80 and over",
"Analysis of Variance",
"Androgen Antagonists",
"Anemia",
"Hemoglobin A",
"Humans",
"Male",
"Middle Aged",
"Neoadjuvant Therapy",
"Neoplasm Staging",
"Prostate-Specific Antigen",
"Prostatic Neoplasms",
"Radiotherapy Dosage",
"Retrospective Studies"
] | null | null | null | no | Anemia is a common side effect of NAST and is usually mild. Hb levels, however, do not predict biochemical control or survival. |
Do non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver? | [
"We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects.",
"Studies were performed using positron emission tomography (PET) and [(18)F]-2-fluoro-2-deoxyglucose ([(18)F]FDG) during euglycaemic hyper... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Biological Transport",
"Fatty Acids, Nonesterified",
"Fluorodeoxyglucose F18",
"Glucose",
"Humans",
"Insulin",
"Kinetics",
"Liver",
"Male",
"Phosphorylation",
"Positron-Emission Tomography",
"Radiopharmaceuticals",
"Reference Values"
] | null | null | null | yes | In healthy men, NEFA impair insulin-mediated HGU and whole-body glucose uptake to a similar extent. Our data suggest that multiple intracellular NEFA targets may concur to down-regulate glucose uptake by the liver. |
Does induction of oral tolerance to oxidized low-density lipoprotein ameliorate atherosclerosis? | [
"Oxidation of low-density lipoprotein (LDL) and the subsequent processing of oxidized LDL (oxLDL) by macrophages results in activation of specific T cells, which contributes to the development of atherosclerosis. Oral tolerance induction and the subsequent activation of regulatory T cells may be an adequate therapy... | [
"BACKGROUND",
"RESULTS"
] | [
"Administration, Oral",
"Animals",
"Atherosclerosis",
"Disease Progression",
"Forkhead Transcription Factors",
"Immune Tolerance",
"Immunoglobulin G",
"Interleukin-2 Receptor alpha Subunit",
"Lipoproteins, LDL",
"Malondialdehyde",
"Mice",
"Mice, Knockout",
"Receptors, LDL",
"T-Lymphocyte S... | null | null | null | yes | OxLDL-specific T cells, present in LDL receptor-/- mice and important contributors in the immune response leading to atherosclerotic plaque, can be counteracted by oxLDL-specific CD4+ CD25+ Foxp3+ regulatory T cells activated via oral tolerance induction to oxLDL. We conclude that the induction of oral tolerance to oxLDL may be a promising strategy to modulate the immune response during atherogenesis and a new way to treat atherosclerosis. |
Is lipoprotein subfraction cholesterol distribution proatherogenic in women with type 1 diabetes and insulin resistance? | [
"Individuals with type 1 diabetes have a less atherogenic fasting lipid profile than those without diabetes but paradoxically have increased rates of cardiovascular disease (CVD). We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Cardiovascular Diseases",
"Chi-Square Distribution",
"Cholesterol",
"Chromatography, Liquid",
"Diabetes Mellitus, Type 1",
"Female",
"Glucose Clamp Technique",
"Humans",
"Hydroxymethylglutaryl-CoA Reductase Inhibitors",
"Insulin Resistance",
"Intra-Abdominal Fat",
"Lipoproteins",
... | null | null | null | yes | The expected sex-based less atherogenic lipoprotein cholesterol distribution was not seen in women with type 1 diabetes. Moreover, insulin resistance was associated with a more atherogenic lipoprotein cholesterol distribution in all men and in women with type 1 diabetes. This lipoprotein cholesterol distribution may contribute to sex-based differences in CVD in type 1 diabetes. |
Does options in pediatric glaucoma after angle surgery have failed? | [
"Congenital glaucoma is primarily a surgical disease with medical management serving as a temporizing measure before surgery or as postoperative adjunctive treatment. First-line surgery for congenital glaucoma consists of incisional procedures on the anterior chamber angle: goniotomy and trabeculotomy. Angle surger... | [
"OBJECTIVE",
"RESULTS"
] | [] | null | null | null | yes | Refractory pediatric glaucoma remains a challenge. Glaucoma drainage devices appear to be the most predictable and possibly safest procedure to consider after failed conventional angle surgery. |
Is beneficial effect of rosuvastatin on cardiac dysfunction associated with alterations in calcium-regulatory proteins? | [
"The normal expression of Ca(2+)-regulatory protein is critical for efficient myocardial function. The present study tested the hypothesis that rosuvastatin treatment may attenuate left ventricular (LV) remodelling and dysfunction in the failing heart, which may be associated with alterations of Ca(2+)-regulatory p... | [
"OBJECTIVE",
"RESULTS"
] | [
"Animals",
"Calcium-Binding Proteins",
"Disease Models, Animal",
"Fluorobenzenes",
"Heart",
"Hydroxymethylglutaryl-CoA Reductase Inhibitors",
"Interleukin-10",
"Interleukin-6",
"Male",
"Organ Size",
"Pyrimidines",
"Rats",
"Rats, Sprague-Dawley",
"Rosuvastatin Calcium",
"Sarcoplasmic Reti... | null | null | null | yes | Rosuvastatin is effective in preventing LV remodelling and dysfunction in the failing heart. The molecular mechanism may be related to normalization of SERCA2a expression, SERCA activity, and pSer16-PLB levels, as well as through cytokine alterations independent of its lipid-lowering effect. |
Is prolonged resuscitation of metabolic acidosis after trauma associated with more complications? | [
"Optimal patterns for fluid management are controversial in the resuscitation of major trauma. Similarly, appropriate surgical timing is often unclear in orthopedic polytrauma. Early appropriate care (EAC) has recently been introduced as an objective model to determine readiness for surgery based on the resuscitati... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Acidosis",
"Adult",
"Algorithms",
"Female",
"Fracture Fixation, Internal",
"Fractures, Bone",
"Humans",
"Injury Severity Score",
"Male",
"Middle Aged",
"Multiple Trauma",
"Practice Guidelines as Topic",
"Predictive Value of Tests",
"Prognosis",
"Prospective Studies",
"Resuscitation",
... | null | null | null | yes | EAC guidelines were safe, effective, and practically implemented in a level 1 trauma center. During the resuscitation course, increased exposure to acidosis was associated with a higher complication rate. Identifying the innate differences in the response, regulation, and resolution of acidosis in these critically injured patients is an important area for trauma research. |
Does nSC23925 prevent the emergence of multidrug resistance in ovarian cancer in vitro and in vivo? | [
"The development of multidrug resistance (MDR) remains the significant clinical challenge in ovarian cancer therapy; however, relatively little is known about how to prevent the emergence of MDR during chemotherapy treatment. NSC23925 previously has been shown to prevent the development of MDR in osteosarcoma cells... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"ATP Binding Cassette Transporter, Subfamily B",
"ATP Binding Cassette Transporter, Subfamily B, Member 1",
"Animals",
"Antineoplastic Agents, Phytogenic",
"Antineoplastic Combined Chemotherapy Protocols",
"Cell Line, Tumor",
"Drug Resistance, Neoplasm",
"Drug Synergism",
"Female",
"Humans",
"Mi... | null | null | null | yes | Our findings suggest that NSC23925 can prevent the emergence of MDR in ovarian cancer both in vitro and in vivo. The clinical use of NSC2395 at the onset of chemotherapy may prevent the development of MDR and improve the clinical outcome of patients with ovarian cancer. |
Does restoration of klotho expression induce apoptosis and autophagy in hepatocellular carcinoma cells? | [
"Klotho has been identified as a tumor suppressor in several human malignancies including hepatocellular carcinoma (HCC). However, the signaling pathways involved in the tumor suppressive role of klotho in HCC have not been reported. Here, we investigated the role of klotho in HCC cell proliferation, apoptosis, aut... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adenine",
"Amino Acid Chloromethyl Ketones",
"Apoptosis",
"Autophagy",
"Blotting, Western",
"Carcinoma, Hepatocellular",
"Cell Line, Tumor",
"Cell Movement",
"Cell Survival",
"Extracellular Signal-Regulated MAP Kinases",
"Flow Cytometry",
"Gene Expression Regulation, Neoplastic",
"Glucuroni... | null | null | null | yes | Klotho is a tumor suppressor that, through the regulation of IGF-1R phosphorylation and subsequent activation of downstream Akt-p70S6K and ERK signaling, regulates HCC tumor cell proliferation, apoptosis, autophagy and invasion. |
Is leukocytosis proportional to HELLP syndrome severity : evidence for an inflammatory form of preeclampsia? | [
"We investigated the possibility that HELLP syndrome is in part a systemic inflammatory response.",
"We evaluated total white blood cell (WBC) counts of all patients with severe preeclampsia with and without HELLP syndrome admitted to our hospital between 1995 and 1997. Patients were grouped by diagnosis and timi... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Analysis of Variance",
"Case-Control Studies",
"Female",
"HELLP Syndrome",
"Humans",
"Inflammation",
"Leukocyte Count",
"Leukocytosis",
"Linear Models",
"Platelet Count",
"Pre-Eclampsia",
"Pregnancy",
"Severity of Illness Index",
"Thrombocytopenia",
"Time Factors"
] | null | null | null | yes | The finding of an association between increasing leukocytosis and worsening thrombocytopenia early in the course of HELLP syndrome supports the hypothesis that it may represent an inflammatory process. |
Does decoy receptor 3 ( DcR3 ) overexpression predict the prognosis and pN2 in pancreatic head carcinoma? | [
"This study was carried out to examine decoy receptor 3 (DcR3) expression and investigate its clinical and prognostic significance in patients with pancreatic head carcinoma.",
"Tissue samples were obtained from 50 patients with pancreatic head carcinoma. DcR3 protein expression in tissues and sera was assessed b... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Biomarkers, Tumor",
"Enzyme-Linked Immunosorbent Assay",
"Female",
"Follow-Up Studies",
"Humans",
"Immunoenzyme Techniques",
"Lymphatic Metastasis",
"Male",
"Middle Aged",
"Neoplasm Grading",
"Neoplasm Staging",
"Pancreas",
"Pancreatic Neoplasms",
"Prognosis",
"Prospective Studies",
"... | null | null | null | yes | We found that DcR3 was overexpressed in pancreatic head carcinoma. The patients with high DcR3 levels had higher pN2 stages than those with low DcR3 levels. Detecting serum DcR3 level preoperatively might be an additional approach for evaluating pN2 stage and guiding the range of lymphadenectomy. |
Does a Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen enhance Chlamydia trachomatis Clearance? | [
"A vaccine for Chlamydia trachomatis is of urgent medical need. We explored bioinformatic approaches to generate an immunogen against C. trachomatis that would induce cross-serovar T-cell responses as (i) CD4(+) T cells have been shown in animal models and human studies to be important in chlamydial protection and ... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [] | null | null | null | yes | A C. trachomatis vaccine needs to induce a robust cellular response with broad cross-serovar coverage and a heterologous prime-boost regimen may be an approach to achieve this. |
Is the angiotensin II type 2 receptor agonist Compound 21 protective in experimental diabetes-associated atherosclerosis? | [
"Angiotensin II is well-recognised to be a key mediator in driving the pathological events of diabetes-associated atherosclerosis via signalling through its angiotensin II type 1 receptor (AT1R) subtype. However, its actions via the angiotensin II type 2 receptor (AT2R) subtype are still poorly understood. This stu... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Angiotensin II Type 2 Receptor Blockers",
"Animals",
"Apolipoproteins E",
"Atherosclerosis",
"Benzimidazoles",
"Biphenyl Compounds",
"Cell Line",
"Diabetes Mellitus, Experimental",
"Humans",
"Male",
"Mice",
"Mice, Inbred C57BL",
"Mice, Knockout",
"Receptor, Angiotensin, Type 2",
"Sulfon... | null | null | null | yes | Taken together, these findings provide novel mechanistic and potential therapeutic insights into C21 as a monotherapy agent against DAA. |
Are fitness and adiposity independently associated with cardiometabolic risk in youth? | [
"The purpose of the study was to examine the independent associations of adiposity and cardiorespiratory fitness with clustered cardiometabolic risk.",
"A cross-sectional sample of 192 adolescents (118 boys), aged 14-16 years, was recruited from a South Lanarkshire school in the West of Scotland. Anthropometry an... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adiposity",
"Adolescent",
"Female",
"Heart",
"Humans",
"Male",
"Metabolism",
"Physical Fitness",
"Regression Analysis",
"Risk Factors",
"Waist Circumference"
] | null | null | null | yes | WC and CRF are independently associated with clustered cardiometabolic risk in Scottish adolescents. |
Does patient-prosthesis mismatch in patients with aortic stenosis undergoing isolated aortic valve replacement affect survival? | [
"Data suggest that patient-prosthesis mismatch (PPM) adversely effects late survival after aortic valve replacement (AVR). This study examined the incidence and implications of PPM in patients undergoing isolated AVR.",
"Prospectively collected data on patients undergoing isolated AVR for aortic stenosis between ... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Aged",
"Aortic Valve Stenosis",
"Female",
"Follow-Up Studies",
"Heart Valve Prosthesis",
"Heart Valve Prosthesis Implantation",
"Hospital Mortality",
"Humans",
"Male",
"Middle Aged",
"Postoperative Period",
"Prospective Studies",
"Prosthesis Failure",
"Prosthesis Fitting",
"Survival Rat... | null | null | null | no | Moderate PPM is common in patients undergoing AVR for aortic stenosis, but severe mismatch is rare. Patients with PPM have similar early and late postoperative survival rate. |
Is lifetime sport and leisure activity participation associated with greater bone size , quality and strength in older men? | [
"It remains uncertain whether long-term participation in regular weight-bearing exercise confers an advantage to bone structure and strength in old age. The aim of this study was to investigate the relationship between lifetime sport and leisure activity participation on bone material and structural properties at t... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Absorptiometry, Photon",
"Aged",
"Aged, 80 and over",
"Bone Density",
"Calcaneus",
"Humans",
"Leisure Activities",
"Male",
"Middle Aged",
"Sports",
"Tomography, X-Ray Computed",
"Ultrasonography",
"Weight-Bearing"
] | null | null | null | yes | In conclusion, these findings indicate that long-term regular participation in sport and leisure activities categorized according to an osteogenic index [but not the total time (min) spent participating in all sport and leisure activities] was an important determinant of bone size, quality and strength, but not BMD, at loaded sites in older men. Furthermore, continued participation in weight-bearing exercise in early to mid-adulthood appears to be important for reducing the risk of low bone strength in old age. |
Does hemizygous deletion of CTGF/CCN2 suffice to prevent fibrosis of the severely injured kidney? | [
"Connective Tissue Growth Factor (CTGF/CCN2) is an important mediator of kidney fibrosis. Previous observations indicated that attenuation of CCN2 expression sufficed to alleviate early kidney damage. However, little is known about the role of CCN2 in fibrosis of severely damaged and more chronically injured kidney... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Analysis of Variance",
"Animals",
"Blotting, Western",
"Connective Tissue Growth Factor",
"Diabetes Mellitus, Experimental",
"Diabetic Nephropathies",
"Fibrosis",
"Haploinsufficiency",
"Immunohistochemistry",
"Mice",
"Mice, Inbred C57BL",
"Microscopy, Electron, Transmission"
] | null | null | null | no | Unlike in mild and relatively early STZ-induced diabetic nephropathy, scarring of severely and chronically damaged kidneys is not attenuated by a 50% reduction of CCN2 to (near) normal levels. This suggests that CCN2 is either redundant in severe and chronic kidney disease, or that it is a limiting factor only at subnormal concentrations requiring further reduction by available or emerging therapies to prevent fibrosis of the severely injured kidney. |
Is severity of hepatic encephalopathy before liver transplantation associated with quality of life after transplantation? | [
"Cirrhosis is associated with a chronic low-grade hepatic encephalopathy and disturbances in quality of life. This study investigated the extent to which severity of hepatic encephalopathy before orthotopic liver transplantation correlated with quality of life.",
"A battery of neuropsychological tests was adminis... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Female",
"Hepatic Encephalopathy",
"Humans",
"Liver Transplantation",
"Male",
"Neuropsychological Tests",
"Prognosis",
"Quality of Life",
"Regression Analysis",
"Time Factors"
] | null | null | null | yes | Severity of hepatic encephalopathy (particularly with respect to static ataxia and fine motor control) is associated with posttransplantation improvement in quality of life. |
Does sutureless securement device reduce complications of peripherally inserted central venous catheters? | [
"This study was conducted to evaluate the performance of a sutureless adhesive-backed device, StatLock, for securement of peripherally inserted central venous catheters (PICCs). Earlier studies have demonstrated that StatLock significantly reduces catheter-related complications when compared to tape. The purpose of... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Catheterization, Central Venous",
"Female",
"Follow-Up Studies",
"Humans",
"Male",
"Middle Aged",
"Prospective Studies",
"Suture Techniques"
] | null | null | null | yes | The sutureless anchor pad was beneficial for both patients and health care providers. Further investigation to determine how StatLock helps reduce catheter-related blood stream infections is necessary. |
Does attachment to laminin-111 facilitate transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts? | [
"In the synovial membrane of patients with rheumatoid arthritis (RA), a strong expression of laminins and matrix degrading proteases was reported.",
"To investigate the regulation of matrix metalloproteinases (MMPs) in synovial fibroblasts (SFs) of patients with osteoarthritis (OA) and RA by attachment to laminin... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Arthritis, Rheumatoid",
"Cells, Cultured",
"Extracellular Signal-Regulated MAP Kinases",
"Female",
"Fibroblasts",
"Gene Expression Regulation, Enzymologic",
"Humans",
"Laminin",
"Male",
"Matrix Metalloproteinase 3",
"Middle Aged",
"Phosphorylation",
"Recombinant Proteins",
"Reve... | null | null | null | yes | Attachment of SF to LM-111 by itself has only minor effects on the expression of MMP-1 or MMP-3, but it facilitates the TGFbeta-induced expression of MMP-3 significantly. This mode of MMP-3 induction may therefore contribute to inflammatory joint destruction in RA independent of the proinflammatory cytokines interleukin (IL)1beta or tumour necrosis factor (TNF)alpha. |
Is functional health literacy associated with health status and health-related knowledge in people living with HIV-AIDS? | [
"Poor health literacy is a prevalent barrier to medical care and people with lower health literacy experience greater illness severity than people with higher health literacy. Health literacy may therefore be an important factor in the health and treatment of people living with HIV-AIDS.",
"A community-recruited ... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"CD4 Lymphocyte Count",
"Educational Status",
"Female",
"HIV Infections",
"Health Education",
"Health Knowledge, Attitudes, Practice",
"Health Status",
"Humans",
"Interviews as Topic",
"Logistic Models",
"Male",
"Middle Aged",
"Patient Compliance",
"Regression Analysis... | null | null | null | yes | Health literacy is a significant factor in the health and treatment of persons living with HIV-AIDS. Interventions are needed to improve medical care and the health status of people with lower health literacy that are living with HIV-AIDS. |
Do trans-aortic Alfieri stitch at the time of septal myectomy for hypertrophic obstructive cardiomyopathy? | [
"Systolic anterior motion (SAM) of the mitral valve, left ventricular outflow tract (LVOT) obstruction, and mitral regurgitation (MR) are known adverse outcomes that can occur after septal myectomy for hypertrophic obstructive cardiomyopathy. The objective of this study was to describe outcomes of a surgical techni... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Cardiac Surgical Procedures",
"Cardiomyopathy, Hypertrophic",
"Echocardiography, Transesophageal",
"Female",
"Follow-Up Studies",
"Heart Septum",
"Humans",
"Male",
"Middle Aged",
"Retrospective Studies",
"Suture Techniques",
"Sutures",
"Treatment Outcome",
"Ventricular Function, Left"
] | null | null | null | yes | Trans-aortic Alfieri stitch placement during septal myectomy is feasible in most cases as an additional tool to improve MR and minimize SAM. This technique may have a role in addressing mitral disease, such as a long anterior leaflet or fibrotic mitral valve, at the time of myectomy without the need for left atriotomy for mitral exposure. |
Does computer-assisted instruction improve clinical reasoning skills of dietetics students? | [
"The effects of a computer-assisted instruction (CAI) tutorial program on learning clinical reasoning skills were compared in undergraduate dietetics students.",
"A drill-and-practice program to control for time on task, and tutorial program, and a simulation program, as the test vehicle, were developed. The tuto... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Analysis of Variance",
"Cardiovascular Diseases",
"Clinical Competence",
"Computer-Assisted Instruction",
"Dietetics",
"Humans"
] | null | null | null | yes | A computer tutorial program enhanced clinical reasoning skills in undergraduate dietetics students. This type of program could be used to supplement many topics taught in diet therapy and provide DPD students with experimental learning before their clinical intern practicums. |
Do soy protein isolates of varied isoflavone content influence serum thyroid hormones in healthy young men? | [
"The ability of soy isoflavones to inhibit thyroid peroxidase and induce goiter in animals has generated concern regarding their potential antithyroid effects in humans. The purpose of this study was to determine the effects of soy protein isolates of varied isoflavone content on circulating thyroid hormones in hea... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Cross-Over Studies",
"Energy Intake",
"Humans",
"Isoflavones",
"Male",
"Soybean Proteins",
"Thyroglobulin",
"Thyroid Hormones",
"Thyrotropin",
"Thyroxine",
"Triiodothyronine"
] | null | null | null | no | Results of this study demonstrate that soy isoflavones in a protein matrix do not significantly influence circulating thyroid hormones in healthy young men. |
Is immunity to blood stages of Plasmodium falciparum dependent on a specific pattern of immunoglobulin subclass responses to multiple blood stage antigens? | [
"In view of the lack of effectiveness of vaccines against Plasmodium falciparum malaria new approaches in the search for antigens and formulations for a vaccine are required. Immunoglobulin responses against several blood stage antigens were only partially associated with protection from symptoms in prospective imm... | [
"BACKGROUND",
"OBJECTIVE"
] | [
"Animals",
"Antibodies, Protozoan",
"Antigens, Protozoan",
"Humans",
"Malaria, Falciparum",
"Models, Immunological",
"Plasmodium falciparum"
] | null | null | null | yes | A confirmation of the hypothesis would support efforts to generate a P. falciparum vaccine containing a comprehensive set of blood stage antigens, which, using adjuvant technology, would lead to the appropriate immunoglobulin subclass response. MEANS TO TEST THE HYPOTHESIS: Detection of multiple immunorelevant P. falciparum blood stage antigens could be achieved by two-dimensional electrophoresis and blotting of the antigens onto nitrocellulose followed by exposure to the participant's serum. Bound immunoglobulins are visualized by isotype specific peroxidase conjugated anti-human immunoglobulin and quantified by transmission densitometry. The resulting pattern of responses for each immunoglobulin isotype could be compared between clinically immune participants remaining asymptomatic with subsequent P. falciparum infections and people who develop malaria. Immunorelevant antigens are identifiable by mass spectrometry with the fully decoded P. falciparum genome. |
Do recombination pattern reanalysis of some HIV-1 circulating recombination forms suggest the necessity and difficulty of revision? | [
"Recombination is one of the major mechanisms underlying the generation of HIV-1 variability. Currently 61 circulating recombinant forms of HIV-1 have been identified. With the development of recombination detection techniques and accumulation of HIV-1 reference stains, more accurate mosaic structures of circulatin... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Genome, Viral",
"HIV-1",
"Molecular Sequence Data",
"Phylogeny",
"Recombination, Genetic",
"Sequence Analysis, DNA"
] | null | null | null | yes | Results indicated that the involvement of multiple recombination detection programs is very necessary. Additionally, results suggested two major challenges, one involving the difficulty of accurately determining the locations of breakpoints and the second involving identification of small regions of about 200 bases or fewer with greater caution. Both indicate the complexity of HIV-1 recombination. The resolution would depend critically on development of a recombination analysis algorithm, accumulation of HIV-1 stains, and a higher sequencing quality. With the changes in recombination pattern, phylogenetic relationships of some CRFs may also change. All these results may be critical to understand the role of recombination in a complex and dynamic HIV evolution. |
Does osteopontin enhance endogenous repair after neonatal hypoxic-ischemic brain injury? | [
"Hypoxic-ischemic (HI) brain injury is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. To identify molecules important for cerebral damage and repair, we investigated the growth factor-related gene expression profile after neonatal cerebral HI. We identified osteopontin (OPN)... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Brain",
"Cell Differentiation",
"Cell Proliferation",
"Gene Expression Profiling",
"Hypoxia-Ischemia, Brain",
"Mice",
"Mice, Knockout",
"Neurons",
"Osteopontin",
"Recovery of Function"
] | null | null | null | yes | OPN plays an important role in repairing brain injury after neonatal HI by regulating cerebral cell proliferation/survival and oligodendrocyte differentiation after injury. The observed promyelinative effect of OPN may offer novel possibilities for a therapy targeting white matter injury. |
Does xenon pretreatment attenuate anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia? | [
"Administration of certain general anesthetics to rodents during the synaptogenic phase of neurodevelopment produces neuronal injury. Preconditioning (pretreatment) can reduce tissue injury caused by a severe insult; the authors investigated whether pretreatment strategies can protect the developing brain from anes... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Anesthetics, Inhalation",
"Animals",
"Animals, Newborn",
"Apoptosis",
"Brain",
"Cohort Studies",
"Hypoxia",
"Ischemic Preconditioning",
"Nitrous Oxide",
"Organ Culture Techniques",
"Rats",
"Rats, Sprague-Dawley",
"Xenon"
] | null | null | null | yes | Although xenon pretreatment protects against nitrous oxide- and isoflurane-induced neuroapoptosis, hypoxic pretreatment exacerbates anesthetic-induced neonatal neurodegeneration. |
Does p130 mediate TGF-beta-induced cell-cycle arrest in Rb mutant HT-3 cells? | [
"The retinoblastoma proteins include Rb and the functionally and structurally related proteins p107 and p130. It has been reported that HT-3 cells are sensitive to TGF-beta growth inhibition, despite the Rb mutation. The purpose of this study was to elucidate the growth-inhibitory mechanism of TGF-beta in Rb mutant... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Blood Proteins",
"Cell Cycle",
"Down-Regulation",
"Female",
"Gene Expression Regulation, Neoplastic",
"Genes, Retinoblastoma",
"Growth Inhibitors",
"Humans",
"Mutation",
"Proteins",
"Retinoblastoma-Like Protein p130",
"Transforming Growth Factor beta",
"Tumor Cells, Cultured",
"Uterine Ce... | null | null | null | yes | Our results demonstrate that p130, instead of Rb, can mediate growth inhibition by TGF-beta in Rb mutant HT-3 cells. |
Are past cervical intraepithelial neoplasia grade 3 , obesity , and earlier menopause associated with an increased risk of vulval cancer in postmenopausal women? | [
"Vulval cancer predominantly affects postmenopausal women. A smaller proportion of vulval cancers, particularly at older ages, are now thought to be associated with human papillomavirus infection than previously reported, but other risk factors have not been well examined in prospective cohort studies.",
"A total... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Aged",
"Cervical Intraepithelial Neoplasia",
"Female",
"Humans",
"Menopause",
"Middle Aged",
"Obesity",
"Risk Factors",
"Vulvar Neoplasms"
] | null | null | null | yes | Past cervical pre-cancer, obesity, and earlier age at menopause are associated with an increased risk of vulval cancer at older ages. |
Is severity of coronary artery disease but not degree of coronary stenosis correlated to cerebrovascular reactivity? | [
"A decade difference in peak incidences of coronary and cerebral ischemia assumes a protection of the brain vasculature. Therefore, we hypothesize that early indicators of cerebrovascular disease such as parameters of the neurovascular coupling show a higher correlation to coronary artery disease than morphologic p... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Carotid Arteries",
"Cerebrovascular Circulation",
"Coronary Angiography",
"Coronary Artery Disease",
"Coronary Stenosis",
"Female",
"Humans",
"Laser-Doppler Flowmetry",
"Male",
"Middle Aged",
"Photic Stimulation",
"Posterior Cerebral Artery",
"Ult... | null | null | null | yes | Although atherosclerosis is a systemic disease our data support concepts of a heterogeneous distribution of the disease indicating protection of brain vessels. |
Do family experiences and pediatric health services use associated with family-centered rounds? | [
"Family-centered rounds (FCR) are defined as interdisciplinary bedside teaching rounds with active family participation. The objective of this study was to examine the association of FCR with family experiences and health services use.",
"Prospective study comparing families with a child admitted to general pedia... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Caregivers",
"Child",
"Child Health Services",
"Child, Preschool",
"Consumer Behavior",
"Cooperative Behavior",
"Female",
"Follow-Up Studies",
"Hospitalization",
"Humans",
"Infant",
"Interdisciplinary Communication",
"Length of Stay",
"Male",
"Outcome Assessment (Health Care)... | null | null | null | yes | FCR are associated with higher parent satisfaction, consistent medical information, and care plan discussion, with no additional burden to health service use. Additional studies should assess FCR under different settings of care. |
Are high doses of ethylene diurea ( EDU ) toxic to willow and act as nitrogen fertilizer? | [
"Ethylene diurea (EDU) is synthetic chemical which protects plants against damage caused by ground level O3 and is used experimentally as a biomonitoring tool at doses usually ranging from 200 to 400mgL(-1) a.i. Although several studies have investigated the protective action of EDU, this mechanism remains unclear.... | [
"UNLABELLED"
] | [
"Air Pollutants",
"Dose-Response Relationship, Drug",
"Environmental Monitoring",
"Fertilizers",
"Nitrogen",
"Ozone",
"Phenylurea Compounds",
"Protective Agents",
"Salix"
] | null | null | null | no | EDU per se does not cause toxicity to willow plants when applied as drench to a soil with no organic matter, rather, high EDU doses may act as nitrogen fertilizer in a nitrogen-poor soil. |
Does high maternal body mass index increase the risk of neonatal early onset group B streptococcal disease? | [
"The aim of this study was to analyse the occurrence of neonatal early onset group B streptococcal (EOGBS) disease relative to maternal body mass index (BMI).",
"A cohort of Swedish parturients with an early pregnancy BMI registered was investigated. Data were retrieved from population-based registers during 1997... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Age Factors",
"Bacteremia",
"Body Mass Index",
"Cohort Studies",
"Confidence Intervals",
"Female",
"Humans",
"Infant, Newborn",
"Male",
"Maternal Welfare",
"Obesity",
"Odds Ratio",
"Overweight",
"Pregnancy",
"Risk Assessment",
"Risk Factors",
"Streptococcal Infections",
"Streptoco... | null | null | null | yes | Maternal obesity and overweight are risk factors associated with increased risk of neonatal EOGBS disease. |
Does caffeic acid phenethyl ester decrease acute pneumonitis after irradiation in vitro and in vivo? | [
"Lung cancer is relatively resistant to radiation treatment and radiation pneumonitis is a major obstacle to increasing the radiation dose. We previously showed that Caffeic acid phenethyl ester (CAPE) induces apoptosis and increases radiosensitivity in lung cancer. To determine whether CAPE, an antioxidant and an ... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Animals",
"Antioxidants",
"Caffeic Acids",
"Fibroblasts",
"Humans",
"Inflammation",
"Lung Neoplasms",
"Male",
"Mice",
"Mice, Inbred BALB C",
"NF-kappa B",
"Oxidative Stress",
"Phenylethyl Alcohol",
"Radiation Pneumonitis",
"Tumor Cells, Cultured"
] | null | null | null | yes | This study suggests that CAPE decreases the cascade of inflammatory responses induced by thoracic irradiation without causing toxicity in normal lung tissue. This provides a rationale for combining CAPE and thoracic radiotherapy for lung cancer treatment in further clinical studies. |
Does thymoglobulin administered early after heart transplantation reduce early myocardial hypertrophy assessed by morphometric studies? | [
"The aim of this study was to assess the effects of early thymoglobulin administration on cardiocyte nuclear status in orthotopic heart transplant (OHT) recipients.",
"We investigated endomyocardial biopsies (EMBs) from 31 OHT recipients and 10 control cases. OHT patients were divided into the standard group who ... | [
"UNLABELLED",
"METHODS",
"RESULTS"
] | [
"Antibodies, Monoclonal",
"Antilymphocyte Serum",
"Biopsy",
"Cardiomegaly",
"Heart Transplantation",
"Humans",
"Immunosuppressive Agents",
"Myocardium",
"Postoperative Complications",
"Postoperative Period"
] | null | null | null | yes | Thymoglobulin administered early after surgery protected cardiocyte hypertrophy in heart transplant recipients, mitigating graft ischemic damage. |
Does dNA-PKcs Expression be a Predictor of Biochemical Recurrence After Permanent Iodine 125 Interstitial Brachytherapy for Prostate Cancer? | [
"Predictive factors for biochemical recurrence (BCR) in localized prostate cancer (PCa) after brachytherapy are insufficient to date. Cellular radiosensitivity depends on DNA double-strand breaks, mainly repaired by the nonhomologous end-joining (NHEJ) system. We analyzed whether the expression of NHEJ proteins can... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Biomarkers, Tumor",
"Brachytherapy",
"DNA-Activated Protein Kinase",
"France",
"Humans",
"Iodine Radioisotopes",
"Male",
"Middle Aged",
"Neoplasm Recurrence, Local",
"Nuclear Proteins",
"Prevalence",
"Prognosis",
"Prostatic Neoplasms",
"Radiopharmaceuticals",
"Reproducibility ... | null | null | null | yes | Our results suggest that DNA-PKcs could be a predictive marker of BCR after brachytherapy, and this might be a useful tool for optimizing the choice of treatment in low-risk PCa patients. |
Does chemotherapy for cancer cause apoptosis that precedes hypoplasia in crypts of the small intestine in humans? | [
"The mechanism of gastrointestinal damage (mucositis) induced by cancer chemotherapy remains uncertain. The aims of this study were to define the time course and mechanism of small intestinal damage following chemotherapy in humans.",
"Patients receiving chemotherapy underwent upper gastrointestinal endoscopy (a ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Antineoplastic Agents",
"Apoptosis",
"Biopsy",
"Disaccharidases",
"Duodenum",
"Endoscopy, Gastrointestinal",
"Enteritis",
"Enterocytes",
"Female",
"Humans",
"In Situ Nick-End Labeling",
"Male",
"Microscopy, Electron",
"Middle Aged",
"Mitotic Index",
... | null | null | null | yes | Small intestinal mucositis is associated with apoptosis in crypts that precedes hypoplastic villous atrophy and loss of enterocyte height. |
Is alveolar macrophage gene expression altered in the setting of alcohol use disorders? | [
"Alcohol use disorders (AUDs) are associated with an increased susceptibility to a variety of common and devastating pulmonary diseases including community- and hospital-acquired pneumonias, as well as the acute respiratory distress syndrome (ARDS). Alveolar macrophages play an important role in preventing the deve... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Alcohol-Related Disorders",
"Alcoholism",
"Bronchoalveolar Lavage",
"Bronchoalveolar Lavage Fluid",
"Female",
"Gene Expression",
"Humans",
"Lung",
"Macrophages, Alveolar",
"Male",
"Middle Aged",
"RNA, Messenger",
"Reverse Transcriptase Polymerase Chain Reaction",
"Transcription... | null | null | null | yes | Alcohol use disorders are associated with unique changes in human alveolar macrophage gene expression. Novel therapies targeting alveolar macrophage gene expression in the setting of AUDs may prove to be clinically useful in limiting susceptibility for pulmonary disorders in these individuals. |
Is a diminished postnatal surge of Ad spermatogonia in cryptorchid infants additional evidence for hypogonadotropic hypogonadism? | [
"The aim of this study was to describe the development of Ad spermatogonia in both unilateral and bilateral cryptorchid infants compared to a control population of comparable age and to note particularly the fate of Ad spermatogonia during the normal surge of testosterone and gonadotropin.",
"The incidence and de... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Biopsy, Needle",
"Case-Control Studies",
"Cryptorchidism",
"Follow-Up Studies",
"Gonadotropins",
"Humans",
"Hypogonadism",
"Immunohistochemistry",
"Infant",
"Infant, Newborn",
"Infertility, Male",
"Male",
"Probability",
"Reference Values",
"Risk Assessment",
"Spermatogenesis",
"Sper... | null | null | null | yes | The impaired transformation of germ cells into Ad spermatogonia in both unilateral and bilateral cryptorchid infant testes during mini-puberty underscores the importance of hypogonadotropic-hypogonadism in the pathogenesis of this disease. |
Are child 's gender and household food insecurity associated with stunting among young Pakistani children residing in urban squatter settlements? | [
"The nutritional status of children is a good indicator of the overall well-being of a society and reflects food security as well as existing health-care and environmental conditions. In Pakistan, it is estimated that nearly 40% to 50% of children under the age of five are stunted. Due to greater economic opportuni... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Body Height",
"Child Nutrition Sciences",
"Cross-Sectional Studies",
"Educational Status",
"Family Characteristics",
"Female",
"Food Supply",
"Health Surveys",
"Humans",
"Infant",
"Infant Nutrition Disorders",
"Infant Nutritional Physiological Phenomena",
"Infant Welfare",
"Logistic Model... | null | null | null | yes | In households where food insecurity exists, knowledge of care practices may not be sufficient, and interventions such as food subsidies must precede or accompany educational efforts. Further follow-up is required to explore the effect of gender differences on child care. |
Is combination therapy with VELCADE and tissue plasminogen activator neuroprotective in aged rats after stroke and targets microRNA-146a and the toll-like receptor signaling pathway? | [
"Activation of the toll-like receptor (TLR) signaling pathway exacerbates ischemic brain damage. The present study tested the hypothesis that combination treatment with VELCADE and tissue plasminogen activator (tPA) modulates the TLR signaling pathway on cerebral vasculature, which leads to neuroprotection in aged ... | [
"OBJECTIVE",
"RESULTS"
] | [
"Aging",
"Animals",
"Boronic Acids",
"Bortezomib",
"Cells, Cultured",
"Down-Regulation",
"Drug Therapy, Combination",
"Humans",
"Male",
"MicroRNAs",
"NF-kappa B",
"Neuroprotective Agents",
"Pyrazines",
"Rats",
"Rats, Wistar",
"Signal Transduction",
"Stroke",
"Tissue Plasminogen Act... | null | null | null | yes | Stroke acutely activates the TLR signaling pathway on cerebral vasculature. Upregulation of miR-146a and inactivation of ischemia and tPA-potentiated TLR signaling pathway by VELCADE may play an important role in the neuroprotective effect of the combination therapy of VELCADE and tPA for acute stroke. |
Is peak weight velocity in infancy negatively associated with lung function in adolescence? | [
"Rapid weight gain during infancy increases childhood asthma risk, which might be related to impaired lung function. This study investigated associations between peak weight velocity (PWV) during the first two years of life and spirometric lung function indices at 15 years of age.",
"Data from 1842 children parti... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Asthma",
"Birth Weight",
"Child Development",
"Cohort Studies",
"Female",
"Follow-Up Studies",
"Forced Expiratory Volume",
"Humans",
"Infant",
"Infant, Newborn",
"Linear Models",
"Lung",
"Male",
"Maximal Midexpiratory Flow Rate",
"Prospective Studies",
"Respiratory Fun... | null | null | null | yes | Early life weight gain was negatively associated with flow indices in adolescence, suggesting structural changes in peripheral lungs. |
Is garlic-derived S-allylmercaptocysteine a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model? | [
"To investigate the hepato-protective properties and underlying mechanisms of SAMC in a non-alcoholic fatty liver disease (NAFLD) rat model.",
"Female rats were fed with a diet comprising highly unsaturated fat diet (30% fish oil) for 8 weeks to develop NAFLD with or without an intraperitoneal injection of 200 mg... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Blotting, Western",
"Cysteine",
"Cytochrome P-450 CYP2E1",
"Cytochrome P-450 CYP2E1 Inhibitors",
"Disease Models, Animal",
"Enzyme-Linked Immunosorbent Assay",
"Fatty Liver",
"Female",
"Garlic",
"Inflammation",
"Lipogenesis",
"Liver",
"MAP Kinase Signaling System",
"NF-kappa ... | null | null | null | yes | SAMC is a novel hepato-protective agent against NAFLD caused by abnormal liver functions. Garlic or garlic derivatives could be considered as a potent food supplement in the prevention of fatty liver disease. |
Does chest compression fraction determine survival in patients with out-of-hospital ventricular fibrillation? | [
"Quality cardiopulmonary resuscitation contributes to cardiac arrest survival. The proportion of time in which chest compressions are performed in each minute of cardiopulmonary resuscitation is an important modifiable aspect of quality cardiopulmonary resuscitation. We sought to estimate the effect of an increasin... | [
"BACKGROUND",
"RESULTS"
] | [
"Aged",
"Cardiopulmonary Resuscitation",
"Cohort Studies",
"Databases, Factual",
"Electric Countershock",
"Emergency Medical Services",
"Female",
"Heart Arrest",
"Humans",
"Male",
"Middle Aged",
"Predictive Value of Tests",
"Tachycardia, Ventricular",
"Ventricular Fibrillation"
] | null | null | null | yes | An increased chest compression fraction is independently predictive of better survival in patients who experience a prehospital ventricular fibrillation/tachycardia cardiac arrest. |
Does expression of snail in pancreatic cancer promote metastasis and chemoresistance? | [
"Pancreatic cancer is a dreadful malignancy. Because of its tendency to metastasis and its resistance to chemotherapy, the prognosis remains poor. Snail is a transcriptional factor that endows epithelial cells with migratory and anti-apoptotic abilities. Its expression has been demonstrated in many tumors. We hypot... | [
"BACKGROUND",
"RESULTS"
] | [
"Animals",
"Cadherins",
"Cell Line, Tumor",
"Drug Resistance, Neoplasm",
"Humans",
"Immunohistochemistry",
"Mice",
"Mice, Nude",
"Neoplasm Invasiveness",
"Neoplasm Metastasis",
"Pancreatic Neoplasms",
"Snail Family Transcription Factors",
"Transcription Factors",
"Vimentin"
] | null | null | null | yes | Snail is expressed in pancreatic cancer; it confers enhanced invasive ability and chemoresistance to pancreatic cancer cells. Snail may be a marker for predicting the malignancy of pancreatic cancer. Further therapy target to Snail may be of great benefit to pancreatic cancer patients. |
Does slug down-regulation by RNA interference inhibit invasion growth in human esophageal squamous cell carcinoma? | [
"Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice.",
"We utilized RNA interference to knockdown Slug gene expression, an... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Animals",
"Apoptosis",
"Blotting, Western",
"Cadherins",
"Carcinoma, Squamous Cell",
"Cell Line, Tumor",
"Disease Models, Animal",
"Down-Regulation",
"Esophageal Neoplasms",
"Gene Expression Regulation, Neoplastic",
"Humans",
"In Vitro Techniques",
"Male",
"Mice",
"Mice, SCID",
"Neopl... | null | null | null | yes | Slug down-regulation promotes cell apoptosis and decreases invasion capability in vitro and in vivo. Slug inhibition may represent a novel strategy for treatment of metastatic ESCC. |
Does postoperative CMF Ameliorate Poor Outcomes in Women With Residual Invasive Breast Cancer After Neoadjuvant Epirubicin/Docetaxel Chemotherapy? | [
"Neoadjuvant chemotherapy (NACT) is an accepted treatment approach in early-stage breast cancer. In contrast, the potential role of postneoadjuvant chemotherapy after taxane-containing NACT remains unclear. The aim of this study was to evaluate postneoadjuvant chemotherapy and further prognostic factors that predic... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Antineoplastic Combined Chemotherapy Protocols",
"Breast Neoplasms",
"Chemotherapy, Adjuvant",
"Cisplatin",
"Disease-Free Survival",
"Female",
"Fluorouracil",
"Humans",
"Kaplan-Meier Estimate",
"Methotrexate",
"Middle Aged",
"Neoadjuvant Therapy",
"Neoplasm, Residual",
"Prognos... | null | null | null | no | In this population, which included a high percentage of patients with luminal cancers, pCR did not predict for improved OS. Postneoadjuvant chemotherapy showed no discernible benefit even in subgroups with aggressive tumor biology or significant remaining tumor burden. The use of such treatment should therefore be discouraged outside of clinical trials. |
Is the WD40 domain required for LRRK2 neurotoxicity? | [
"Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson disease (PD). LRRK2 contains an \"enzymatic core\" composed of GTPase and kinase domains that is flanked by leucine-rich repeat (LRR) and WD40 protein-protein interaction domains. While kinase activity and GTP-binding ... | [
"BACKGROUND",
"RESULTS"
] | [
"Animals",
"Cell Line",
"Humans",
"Mice",
"Models, Molecular",
"Molecular Weight",
"Neurotoxins",
"Phosphorylation",
"Protein Multimerization",
"Protein Structure, Tertiary",
"Protein-Serine-Threonine Kinases",
"Sequence Deletion",
"Structural Homology, Protein",
"Structure-Activity Relati... | null | null | null | yes | These findings suggest that LRRK2 dimerization and autophosphorylation may be required for the neurotoxicity of LRRK2 PD mutations and highlight a potential role for the WD40 domain in the mechanism of LRRK2-mediated cell death. |
Does monoclonal leukocyte antibody decrease the injury of transient focal cerebral ischemia in cats? | [
"We tested the hypothesis that inhibition of leukocyte function by administration of monoclonal antibody 60.3 (MoAb 60.3) improves electrophysiological recovery and decreases injury volume following transient focal cerebral ischemia in cats.",
"Halothane-anesthetized cats underwent 90 minutes of left middle cereb... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Antibodies, Monoclonal",
"Cats",
"Cerebrovascular Circulation",
"Evoked Potentials, Somatosensory",
"Female",
"Ischemic Attack, Transient",
"Leukocytes",
"Reperfusion",
"Somatosensory Cortex"
] | null | null | null | no | Inhibition of leukocyte function with MoAb 60.3 does not afford protection from severe focal ischemia and reperfusion in cats. |
Does prenatal lipopolysaccharide exposure affect maternal behavior and male offspring sexual behavior in adulthood? | [
"This study investigates the effects of prenatal lipopolysaccharide (LPS) exposure on the maternal behavior of pregnant rats and the physical development and sexual behavior of their male offspring in adulthood.",
"For two experiments, pregnant rats were injected with LPS (250 microg/kg, i.p.) on gestation day (G... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Animals, Newborn",
"Body Weight",
"Brain",
"Disease Models, Animal",
"Disorders of Sex Development",
"Ejaculation",
"Female",
"Imprinting (Psychology)",
"Inflammation Mediators",
"Male",
"Maternal Behavior",
"Pregnancy",
"Prenatal Exposure Delayed Effects",
"Rats",
"Rats, W... | null | null | null | yes | We propose that prenatal LPS exposure on GD21 acts as an imprinting factor that interferes with the programming of brain sexual determination in offspring. |
Do adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease? | [
"Several circulating cytokines are increased with obesity and may combine with the influence of visceral fat to generate insulin resistance, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD). Little information exists in NAFLD about three recently recognized tissue-derived cytokines that are al... | [
"UNLABELLED"
] | [
"Acute-Phase Proteins",
"Adult",
"Fatty Acid-Binding Proteins",
"Fatty Liver",
"Female",
"Hepatitis",
"Humans",
"Lipocalin-2",
"Lipocalins",
"Liver Cirrhosis",
"Male",
"Middle Aged",
"Proto-Oncogene Proteins"
] | null | null | null | yes | Circulating AFABP, produced by adipocytes and macrophages, and lipocalin-2, produced by multiple tissues, are elevated and may contribute to the metabolic syndrome in NAFLD. AFABP levels, which correlate with subcutaneous, but not visceral fat, independently predict inflammation and fibrosis in NAFLD and may have a direct pathogenic link to disease progression. |
Is timing variability during gait initiation increased in people with Alzheimer 's disease compared to controls? | [
"Variability of constant speed walking is closely related to falls risk in people with Alzheimer's disease (AD) who fall at 3 times the rate of normal elders. Falls are likely to be provoked during gait initiation, so this study aimed to determine if people with mild-moderate AD have greater variability of gait at ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Accidental Falls",
"Aged",
"Aged, 80 and over",
"Alzheimer Disease",
"Biomechanical Phenomena",
"Female",
"Gait",
"Gait Disorders, Neurologic",
"Humans",
"Male",
"Risk Factors",
"Walking"
] | null | null | null | yes | Increased timing variability in people with AD occurs during gait initiation as well as during constant speed walking and is evident in the early disease stages. |
Does pitching biomechanics as a pitcher approach muscular fatigue during a simulated baseball game? | [
"The effects of approaching muscular fatigue on pitching biomechanics are currently unknown. As a pitcher fatigues, pitching mechanics may change, leading to a decrease in performance and an increased risk of injury.",
"As a pitcher approaches muscular fatigue, select pitching biomechanical variables will be sign... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Analysis of Variance",
"Arm",
"Baseball",
"Biomechanical Phenomena",
"Humans",
"Male",
"Muscle Fatigue",
"Psychomotor Performance",
"Range of Motion, Articular",
"Torque",
"Video Recording"
] | null | null | null | yes | The relatively few differences observed imply that pitching biomechanics remained remarkably similar between collegiate starting pitchers who threw between 105 and 135 pitches for 7 to 9 innings and approached muscular fatigue. |
Is the Bisphosphonate Pamidronate an Intestinal Antiinflammatory Agent in Rat and Mouse Experimental Colitis? | [
"Statins have antiinflammatory effects at the cardiovascular level because of inhibition of prenylation, which also probably underlies their therapeutic effects in preclinical models of inflammatory bowel disease. Another inhibitor of prenylation, namely alendronate, reduces colitis in rodents. In this study, we ai... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Alendronate",
"Animals",
"Anti-Inflammatory Agents",
"Colitis",
"Dextran Sulfate",
"Diphosphonates",
"Ibandronic Acid",
"Immunologic Factors",
"Intestinal Mucosa",
"Mice",
"Pamidronate",
"Rats",
"T-Lymphocytes",
"Trinitrobenzenesulfonic Acid"
] | null | null | null | yes | Pamidronate presents antiinflammatory and immunomodulatory properties in 3 different models of experimental colitis in rodents. This effect requires oral administration and may involve T cells in the gut mucosa, although the exact mechanism is unclear. |
Does experience with bilateral cochlear implants improve sound localization acuity in children? | [
"Because of auditory plasticity, there can be experience-dependent acquisition and refinement of spatial hearing skills.",
"A growing number of children who are deaf are receiving bilateral cochlear implants (CIs), in an attempt to provide them with acoustic cues known to be important for spatial hearing. A feasi... | [
"OBJECTIVE",
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Child",
"Child, Preschool",
"Cochlear Implants",
"Female",
"Hearing Loss, Bilateral",
"Humans",
"Longitudinal Studies",
"Male",
"Sound Localization",
"Treatment Outcome"
] | null | null | null | yes | Spatial hearing skills in sequentially implanted children develop in an experience-dependent manner, perhaps because of the ability of the auditory system to use newly acquired electrical stimulation presented to the 2 ears. |
Does gM-CSF contribute to prompt healing of ecthyma gangrenosum lesions in kidney transplant recipient? | [
"Ecthyma gangrenosum (EG) is an unusual, potentially fatal cutaneous disease, commonly associated with Pseudomonas aeruginosa septicemia.",
"We report the case of a 61-year-old man admitted to the Nephrology Department for fever, leukopenia and inguinal and scrotal painful lesions. Physical examination revealed i... | [
"BACKGROUND",
"METHODS"
] | [
"Ecthyma",
"Granulocyte-Macrophage Colony-Stimulating Factor",
"Humans",
"Immunocompromised Host",
"Kidney Transplantation",
"Male",
"Middle Aged",
"Pseudomonas Infections",
"Pseudomonas aeruginosa"
] | null | null | null | yes | We suggest that the combination of GM-CSF with appropriate antibiotics can resolve EG and avoid or minimize the risk of septicemia in immunosuppressed patients. |
Is pterygium related to a decrease in corneal endothelial cell density? | [
"The aim of this study was to investigate the relationship between pterygium and a decrease in the corneal endothelial cell density (ECD) in patients with unilateral primary pterygium.",
"In this retrospective cross-sectional study, 90 consecutive patients with unilateral primary pterygium were enrolled from Janu... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Astigmatism",
"Cell Count",
"Corneal Endothelial Cell Loss",
"Cross-Sectional Studies",
"Endothelium, Corneal",
"Female",
"Humans",
"Male",
"Middle Aged",
"Pterygium",
"Retrospective Studies"
] | null | null | null | yes | Pterygium is related to a decrease in corneal ECD. Surgical intervention should be considered in patients with extensive pterygium involvement in the cornea or a significant increase in astigmatism. |
Is long-term reversal of hypocholesterolaemia in patients with chronic hepatitis C related to sustained viral response and viral genotype? | [
"Genotype-3 of hepatitis C virus (HCV) has been associated with serum lipid changes (reversible with sustained viral response) and liver steatosis.",
"To characterize the relationships among hepatic steatosis, cholesterol and sustained viral response in these patients.",
"Patients (n = 215) with chronic hepatit... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"C-Peptide",
"Cholesterol",
"Dyslipidemias",
"Fatty Liver",
"Female",
"Genotype",
"Hepatitis C, Chronic",
"Humans",
"Leptin",
"Male",
"Middle Aged"
] | null | null | null | yes | Besides causing hepatic steatosis, genotype-3 specifically decreases serum cholesterol. This interference with the metabolic lipid pathway is related to viral load, is reversed with sustained viral response, and seems unrelated to mitochondrial dysfunction. |
Is life style intervention in moderately overweight individuals associated with decreased levels of cathepsins L and S in plasma? | [
"Adipose tissue cells produce cathepsins L and S, which have proatherogenic effects. Obesity is strongly linked to atherogenesis, cardiovascular morbidity, and mortality.",
"The aim of the present study was to see if life style interventions/weight reduction could decrease cathepsin L and S levels in blood plasma... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Cathepsin L",
"Cathepsins",
"Female",
"Humans",
"Life Style",
"Male",
"Middle Aged",
"Overweight",
"Weight Loss"
] | null | null | null | yes | The intervention program resulted in significant reductions of cathepsin L and S levels in plasma after 4 and 8 weeks of intervention. |
Is a Novel Polymorphism of the CYP19 Gene Associated with Essential Hypertension in China? | [
"Aromatase which is encoded by the CYP19 gene is a key enzyme in the conversion of androgen to estrogen and plays an important role in the balance of the gender hormone levels. The gender hormone has a causal role in the development of cardiovascular disease. The goal of this study was to investigate the interactio... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aromatase",
"Asian Continental Ancestry Group",
"Blood Pressure",
"Case-Control Studies",
"Chi-Square Distribution",
"China",
"Female",
"Gene Frequency",
"Genetic Association Studies",
"Genetic Predisposition to Disease",
"Heterozygote",
"Homozygote",
"Humans",
"Hyper... | null | null | null | yes | The T allele of rs2289105 in CYP19 gene might be a protective genetic marker of EH for women in Han population. |
Are different alternative splicing patterns subject to opposite selection pressure for protein reading frame preservation? | [
"Alternative splicing (AS) has been regarded capable of altering selection pressure on protein subsequences. Particularly, the frequency of reading frame preservation (FRFP), as a measure of selection pressure, has been reported to be higher in alternatively spliced exons (ASEs) than in constitutively spliced exons... | [
"BACKGROUND",
"RESULTS"
] | [
"Alternative Splicing",
"Animals",
"Exons",
"Humans",
"Mice",
"Reading Frames",
"Selection, Genetic"
] | null | null | null | yes | In this study, we find that simple and complex ASEs undergo opposite selection pressure for protein reading frame preservation, with CSEs in-between. Simple ASEs have much higher FRFPs than complex ones. We further find that the FRFPs of complex ASEs coupled with flanking exons are close to those of simple ASEs, indicating that neighboring exons of an ASE may evolve in a coordinated way to avoid protein dysfunction. Therefore, we suggest that evolutionary analyses of AS should take into consideration the effects of different splicing patterns and the joint effects of multiple AS events. |
Does high nuclear expression of HDGF correlate with disease progression and poor prognosis in human endometrial carcinoma? | [
"This study examined the correlation between high nuclear expression of hepatoma-derived growth factor (HDGF) and clinicopathologic data in endometrial carcinoma (EC), including patient survival.",
"One hundred and twenty-two endometrial carcinoma (EC) patients from 2002 to 2008 were reviewed in the study. HDGF e... | [
"OBJECTIVE",
"METHODS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Biomarkers, Tumor",
"Carcinoma",
"Cell Nucleus",
"Disease Progression",
"Endometrial Neoplasms",
"Endometrium",
"Female",
"Gene Expression",
"Humans",
"Intercellular Signaling Peptides and Proteins",
"Kaplan-Meier Estimate",
"Lymphatic Metastasis",
... | null | null | null | yes | Immunohistochemical analysis revealed that HDGF was expressed in both the nucleus and cytoplasm. High nuclear expression of HDGF was positively correlated with FIGO stage (P = 0.032), but not associated with other clinical features, such as histological grading or lymph node status. Patients with high expression of HDGF had poorer overall survival rates than those with low expression of HDGF (P = 0.001). However, multivariate analyses showed that high nuclear expression of HDGF protein was not an independent predictor of prognosis for EC patients (P = 0.111). Our results suggest that high nuclear expression of HDGF is a potential unfavorable factor for the progression and prognosis of EC. |
Is 18F-fluorodeoxyglucose-positron emission tomography scanning more useful in followup than in the initial assessment of patients with Erdheim-Chester disease? | [
"Erdheim-Chester disease (ECD) is a rare form of non-Langerhans' cell histiocytosis. The aim of this study was to assess the value of whole-body scanning with (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in a large cohort of ECD patients from a single center.",
"We retrospectively reviewed all ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Cohort Studies",
"Erdheim-Chester Disease",
"Female",
"Fluorodeoxyglucose F18",
"Follow-Up Studies",
"Humans",
"Male",
"Middle Aged",
"Observer Variation",
"Positron-Emission Tomography",
"Retrospective Studies",
"Sensitivity and Specificity",
"Severity of Illness Index... | null | null | null | yes | The results of our large, single-center, retrospective study suggest that the findings of a FDG-PET scan may be interesting in the initial assessment of patients with ECD, but its greater contribution is in followup of these patients. |
Is mitochondrial uncoupling protein 2 up-regulated in human head and neck , skin , pancreatic , and prostate tumors? | [
"Mitochondrial uncoupling protein 2 (UCP2) uncouples electron transport from ATP production. UCP2 has been shown to play an important role in obesity and diabetes. Interestingly, studies have demonstrated that UCP2 is up-regulated in human colon cancer samples.",
"In order to study the role of UCP2 in human cance... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adenocarcinoma",
"Adult",
"Aged",
"Aged, 80 and over",
"Carcinoma, Squamous Cell",
"Female",
"Head and Neck Neoplasms",
"Humans",
"Ion Channels",
"Male",
"Middle Aged",
"Mitochondrial Proteins",
"Pancreatic Neoplasms",
"Prostatic Neoplasms",
"Skin Neoplasms",
"Uncoupling Protein 2",
... | null | null | null | yes | Over expression of UCP2 in certain tumors provides the rationale to speculate that UCP2 may promote tumor growth in these cancers. |
Does matrix metalloproteinase-9 deletion rescue auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome? | [
"Sensory processing deficits are common in autism spectrum disorders, but the underlying mechanisms are unclear. Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism. Electrophysiological responses in humans with FXS show reduced habituation with sound repetition and this defici... | [
"UNLABELLED"
] | [
"Acoustic Stimulation",
"Adaptation, Physiological",
"Animals",
"Auditory Cortex",
"Disease Models, Animal",
"Evoked Potentials, Auditory",
"Fragile X Mental Retardation Protein",
"Fragile X Syndrome",
"Matrix Metalloproteinase 9",
"Mice",
"Mice, Knockout",
"Up-Regulation"
] | null | null | null | yes | Fragile X Syndrome (FXS) is the leading known genetic cause of autism spectrum disorders. Individuals with FXS show symptoms of auditory hypersensitivity. These symptoms may arise due to sustained neural responses to repeated sounds, but the underlying mechanisms remain unclear. For the first time, this study shows deficits in habituation of neural responses to repeated sounds in the Fmr1 KO mice as seen in humans with FXS. We also report an abnormally high level of matrix metalloprotease-9 (MMP-9) in the auditory cortex of Fmr1 KO mice and that deletion of Mmp-9 from Fmr1 KO mice reverses habituation deficits. These data provide a translation relevant electrophysiological biomarker for sensory deficits in FXS and implicate MMP-9 as a target for drug discovery. |
Does air quality influence the prevalence of hay fever and sinusitis? | [
"Determine associations between air quality and the prevalence of hay fever and sinusitis.",
"Cross-sectional study.",
"The National Health Interview Survey for the calendar years 1997-2006 adult sample was analyzed to determine for each calendar year the one-year period prevalence of the two respiratory condit... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Age Distribution",
"Air Pollution",
"Cross-Sectional Studies",
"Female",
"Follow-Up Studies",
"Humans",
"Male",
"Middle Aged",
"Population Surveillance",
"Prevalence",
"Retrospective Studies",
"Rhinitis, Allergic, Seasonal",
"Sinusitis",
"Time Factors",
"United States"
] | null | null | null | yes | Prevalence of hay fever and sinusitis are correlated with air quality. Improvements in air quality are associated with decreased prevalence of both hay fever and sinusitis. Laryngoscope, 2009. |
Does s 23521 decrease food intake and body weight gain in diet-induced obese rats? | [
"To investigate the effect of S 23521, a new glucagon-like peptide-1-(7-36) amide analogue, on food intake and body weight gain in obese rats, as well as on gene expression of several proteins involved in energy homeostasis.",
"Lean and diet-induced obese rats were treated with either S 23521 or vehicle. S 23521 ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adipose Tissue",
"Animals",
"Anti-Obesity Agents",
"Dose-Response Relationship, Drug",
"Eating",
"Energy Metabolism",
"Glucagon",
"Glucagon-Like Peptide 1",
"Glucagon-Like Peptides",
"Injections, Intraperitoneal",
"Injections, Subcutaneous",
"Male",
"Obesity",
"Peptide Fragments",
"Rand... | null | null | null | yes | S 23521 is an effective glucagon-like peptide-1-(7-36) amide analogue, which induced a decrease in energy intake, body weight, and adiposity in a rat model of diet-induced obesity. In addition, the treatment also improved glucose tolerance and insulin sensitivity of obese rats. These results strongly support S 23521 as a putative molecule for the treatment of obesity. |
Are anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice dependent on age of first exposure to Toxoplasma gondii? | [
"Toxoplasma gondii is a pathogen implicated in psychiatric disorders. As elevated antibodies to T. gondii are also present in non-symptomatic individuals, we hypothesized that the age during first exposure to the pathogen may affect symptom manifestation. We tested this hypothesis by evaluating neurobehavioral abno... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Aging",
"Animals",
"Autoantibodies",
"Brain",
"Immunoglobulin G",
"Male",
"Mental Disorders",
"Mice, Inbred BALB C",
"Receptors, N-Methyl-D-Aspartate",
"Toxoplasma",
"Toxoplasmosis"
] | null | null | null | yes | Our study demonstrates that the age at first exposure to T. gondii is an important factor in shaping distinct behavioral and neurobiological abnormalities. Elevation in GLUN2 autoantibodies or complement protein C1q may be a potential underlying mechanism. A better understanding of these age-related differences may lead to more efficient treatments of behavioral disorders associated with T. gondii infection. |
Is risedronate gastrointestinal absorption independent of site and rate of administration? | [
"Two studies were conducted to compare the absorption of risedronate administered as a solution to three different gastrointestinal sites (study A) and to determine the extent of absorption of risedronate solution administered by rapid and slow infusion to the second part of the duodenum (study B).",
"Each study ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Area Under Curve",
"Calcium Channel Blockers",
"Dosage Forms",
"Duodenum",
"Etidronic Acid",
"Gastric Mucosa",
"Humans",
"Ileum",
"Intestinal Absorption",
"Male",
"Risedronic Acid"
] | null | null | null | yes | These studies indicate that the rate and extent of risedronate absorption are independent of the site of administration along the gastrointestinal tract, and that the extent of absorption is not affected by the rate of administration. |
Does neutrophil gelatinase-associated lipocalin protect renal tubular epithelial cells in hypoxia-reperfusion by reducing apoptosis? | [
"The aim of this study was to elucidate the role of neutrophil gelatinase-associated lipocalin (NGAL) in regulating apoptosis of tubular epithelial cells in a hypoxia-reperfusion model.",
"A hypoxia-reperfusion model was established with NRK-52E cells to assess apoptosis and cell cycle progression after the addit... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Acute-Phase Proteins",
"Animals",
"Apoptosis",
"Cell Hypoxia",
"Cell Line",
"Cell Proliferation",
"Down-Regulation",
"Epithelial Cells",
"Fas Ligand Protein",
"Kidney Tubules",
"Lipocalins",
"Low Density Lipoprotein Receptor-Related Protein-2",
"Proto-Oncogene Proteins",
"Proto-Oncogene P... | null | null | null | yes | These findings indicate that NGAL reduces apoptosis by regulating the four apoptosis factors Bcl-2, Bax, Fas and FasL through its two receptors 24p3R and megalin. These results also suggest that ectopic expression of NGAL in renal cells might provide a therapeutic strategy in ischemia-reperfusion by reducing apoptosis and promoting renal cell proliferation. |
Is high body mass index associated with increased diurnal strains in the articular cartilage of the knee? | [
"Obesity is an important risk factor for osteoarthritis (OA) and is associated with changes in both the biomechanical and inflammatory environments within the joint. However, the relationship between obesity and cartilage deformation is not fully understood. The goal of this study was to determine the effects of bo... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Body Mass Index",
"Cartilage, Articular",
"Case-Control Studies",
"Circadian Rhythm",
"Female",
"Humans",
"Knee Joint",
"Magnetic Resonance Imaging",
"Male",
"Obesity",
"Osteoarthritis, Knee",
"Risk Factors",
"Stress, Mechanical",
"Weight-Bearing"
] | null | null | null | yes | Increased BMI is associated with increased diurnal strains in articular cartilage of both the medial and lateral compartments of the knee. The increased cartilage strains observed in individuals with high BMI may, in part, explain the elevated risk of OA associated with obesity or may reflect alterations in the cartilage mechanical properties in subjects with high BMI. |
Does corticosterone mediate electroacupuncture-produced anti-edema in a rat model of inflammation? | [
"Electroacupuncture (EA) has been reported to produce anti-edema and anti-hyperalgesia effects on inflammatory disease. However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model.",
"Three experiments were conducted on male Sprague-Dawle... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adrenal Glands",
"Adrenalectomy",
"Animals",
"Corticosterone",
"Disease Models, Animal",
"Edema",
"Electroacupuncture",
"Freund's Adjuvant",
"Hormone Antagonists",
"Hyperalgesia",
"Inflammation",
"Male",
"Mifepristone",
"Rats",
"Rats, Sprague-Dawley",
"Receptors, Glucocorticoid",
"R... | null | null | null | yes | The data demonstrate that EA activates the adrenals to increase plasma corticosterone levels and suppress edema and suggest that EA effects differ in healthy subjects and in those with pathologies. |
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