QUESTION stringlengths 17 664 | CONTEXTS listlengths 1 12 | LABELS listlengths 1 12 | MESHES listlengths 0 46 | YEAR stringclasses 0
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values | reasoning_free_pred stringclasses 0
values | final_decision stringclasses 2
values | LONG_ANSWER stringlengths 1 3.12k |
|---|---|---|---|---|---|---|---|---|
Is high expression of mammalian target of rapamycin associated with better outcome for patients with early stage lung adenocarcinoma? | [
"Mammalian target of rapamycin (mTOR) is a key kinase downstream of phosphoinositide 3-kinase (PI3K)/AKT predominantly involved in translational control in the presence of nutrients and energy. Despite the well known role of mTOR in carcinogenesis, its prognostic potential in lung cancer has not been investigated. ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adenocarcinoma",
"Aged",
"Biomarkers, Tumor",
"Cell Line, Tumor",
"Cohort Studies",
"Female",
"Follow-Up Studies",
"Humans",
"Lung Neoplasms",
"Male",
"Middle Aged",
"Multivariate Analysis",
"Neoplasm Staging",
"Prognosis",
"Protein Kinases",
"TOR Serine-Threonine Kinases",
"Tissue ... | null | null | null | yes | mTOR expression defines a subgroup of patients with a favorable outcome and may be useful for prognostic stratification of lung adenocarcinoma patients as well as incorporation of mTOR into clinical decisions. |
Does hypoxia exposure induce the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia? | [
"Cultured fibroblasts of hypoxia-stimulated remodelled pulmonary artery (PA) adventitia proliferate at a greater rate compared with those of normal adventitia. Since protein kinase C (PKC) zeta is a replication repressor of normal adventitial fibroblasts, we hypothesized that loss of the repressor activity of PKCze... | [
"OBJECTIVE",
"RESULTS"
] | [
"Animals",
"Cattle",
"Cell Proliferation",
"Cells, Cultured",
"Connective Tissue",
"Disease Models, Animal",
"Enzyme Activation",
"Fibroblasts",
"Hypoxia",
"Immunoenzyme Techniques",
"MAP Kinase Kinase 1",
"MAP Kinase Kinase 2",
"Mitogen-Activated Protein Kinase 1",
"Mitogen-Activated Prot... | null | null | null | yes | PKCzeta acts as a replication repressor in Fib-C cells; however, the same isozyme mediates Fib-H proliferation. Thus, chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the PA adventitia. |
Does mesenchymal stem cell irradiation in culture engage differential effect of hyper-fractionated radiotherapy for head and neck cancers? | [
"The purpose of this study was to challenge current knowledge on the potential therapeutic advantages of stem cells in radiotherapy by developing an in vitro model of the healthy tissue surrounding or replacing the widely resected tumor. After radical surgery, the start of radiotherapy is often delayed due to wound... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Cell Culture Techniques",
"Cell Division",
"Cell Separation",
"Cobalt Radioisotopes",
"Dose Fractionation, Radiation",
"Dose-Response Relationship, Radiation",
"Gamma Rays",
"Head and Neck Neoplasms",
"Humans",
"Immunophenotyping",
"Mesenchymal Stem Cells",
"Osteoblasts",
"Radiotherapy"
] | null | null | null | yes | To our knowledge, this study is the first to investigate the biophysics of low dose gamma irradiation on stem cell culture, focusing on the potential applications in radiation oncology. For advanced oral cavity and oropharyngeal cancers, as radical surgery often implies major bone resection, the use of mesenchymal stem... |
Is the frequency of chromosome 7q interstitial deletions associated with B-cell lymphoproliferative disorders substantially high among hematological malignancies? | [
"To study the frequency of interstitial 7q deletions in B-cell lymphoproliferative disorders (B-LPDs).",
"Cases were collected from the clinical laboratory diagnosis database at USLabs/LabCorp over the past two years (2002 to 2004). Cases that showed deletions in the long arm of chromosome 7 were then reviewed. I... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Aged, 80 and over",
"Chromosome Deletion",
"Chromosome Mapping",
"Chromosomes, Human, Pair 7",
"Female",
"Hematologic Neoplasms",
"Humans",
"Karyotyping",
"Leukemia, Lymphocytic, Chronic, B-Cell",
"Male",
"Middle Aged"
] | null | null | null | yes | (1) The frequency of 7q interstitial deletions associated with B-LPDs is substantially high; (2) 7q interstitial deletions are not uncommon in B-CLL. |
Is cyr61/CCN1 involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway? | [
"Interleukin-8 (IL-8) is an important factor in the pathogenesis of psoriasis vulgaris, which is characterized by proliferation of keratinocytes, neutrophil infiltration and angiogenesis. Cysteine-rich 61 (Cyr61/CCN1), a secreted extracellular matrix protein, is a novel proinflammatory factor. Whether Cyr61 is invo... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Animals",
"Cell Line",
"Cysteine-Rich Protein 61",
"Female",
"Humans",
"Interleukin-1beta",
"Interleukin-8",
"Keratinocytes",
"MAP Kinase Signaling System",
"Male",
"Mice, Inbred BALB C",
"Middle Aged",
"NF-kappa B",
"Psoriasis",
"RNA, Small Interfering",
"Skin",
"Tumor N... | null | null | null | yes | Our results not only reveal a novel mechanism illustrating the role of Cyr61 in epidermis pathogenesis but also suggest that therapies targeting Cyr61 may represent a novel strategy in the treatment of psoriasis vulgaris. |
Does recombination between homologous chromosomes play a dominant role in the formation of radiation-induced chromosomal aberrations? | [
"In mammalian cells, the relevance of homologous recombination in radiation-induced double-strand break (DSB) repair is not yet well understood. In the present work, the role of recombination between homologous chromosomes and homology-directed repair of DSB were studied, using X-ray-induced chromosomal aberrations... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"CHO Cells",
"Chromosome Aberrations",
"Cricetinae",
"DNA Damage",
"DNA Repair",
"G2 Phase",
"Recombination, Genetic",
"X-Rays"
] | null | null | null | no | In hamster cells, recombination between homologous chromosomes appears not to have a major role in the formation of radiation-induced chromosomal aberrations, while nonhomologous repair seems to be important in both the G and G2 phases of the cell cycle. |
Does a single instillation of epirubicin after transurethral resection of bladder tumors prevent only small recurrences? | [
"We studied whether a single instillation of epirubicin after transurethral bladder tumor resection would influence the interval to and size of the first recurrence.",
"A total of 404 patients from 13 hospitals were randomized to 1 instillation of 50 mg epirubicin or placebo within 6 hours after transurethral res... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Administration, Intravesical",
"Aged",
"Antibiotics, Antineoplastic",
"Cystectomy",
"Epirubicin",
"Female",
"Humans",
"Male",
"Neoplasm Recurrence, Local",
"Prospective Studies",
"Urethra",
"Urinary Bladder Neoplasms"
] | null | null | null | yes | We confirmed the results of previous studies showing that 8.5 patients must be treated with a single instillation to prevent 1 recurrence. Furthermore, our data may indicate that only small recurrences are prevented, which could easily be fulgurated using local anesthesia at followup cystoscopy. The benefit of single i... |
Does computer modeling with randomized-controlled trial data inform the development of person-centered aged care homes? | [
"To answer questions on the essential components (services, operations and resources) of a person-centered aged care home (iHome) using computer simulation.",
"iHome was developed with AnyLogic software using extant study data obtained from 60 Australian aged care homes, 900+ clients and 700+ aged care staff. Bay... | [
"OBJECTIVE",
"METHODS"
] | [
"Aged",
"Australia",
"Health Services Research",
"Homes for the Aged",
"Humans",
"Models, Statistical",
"Nursing Homes",
"Patient-Centered Care",
"Randomized Controlled Trials as Topic"
] | null | null | null | yes | Further testing will define essential characteristics of a person-centered care home. |
Does hyaluronan suppress lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathway? | [
"Intra-articular injection of local anesthetics (LAs) is a common procedure for therapeutic purposes. However, LAs have been found toxic to articular cartilage, and hyaluronan may attenuate this toxicity. In this study we investigated whether hyaluronan attenuated lidocaine-induced chondrotoxicity, and if so, to el... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Anesthetics, Local",
"Animals",
"Animals, Newborn",
"Apoptosis",
"Cells, Cultured",
"Chondrocytes",
"Humans",
"Hyaluronic Acid",
"Lidocaine",
"Membrane Potential, Mitochondrial",
"Mice",
"Mitochondria",
"Oxidative Stress",
"Signal Transduction",
"Tumor Suppressor Protein p53"
] | null | null | null | yes | Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro through inhibiting the p53-dependent mitochondrial apoptotic pathway. |
Does in vivo airway eosinophil accumulation enhance antigen- or propranolol-induced bronchoconstriction in guinea pigs? | [
"Chronic airway eosinophil accumulation is characteristic of asthma. However, it remains unclear whether airway eosinophils enhance or reduce release of chemical mediators and/or action of the released mediators in the airways in vivo, because previous investigators have indicated that eosinophil-derived factors su... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Administration, Inhalation",
"Administration, Intranasal",
"Animals",
"Antigens",
"Asthma",
"Bronchoconstriction",
"Bronchoconstrictor Agents",
"Disease Models, Animal",
"Eosinophils",
"Guinea Pigs",
"Lipids",
"Male",
"Methacholine Chloride",
"Mice",
"Polymyxin B",
"Propranolol",
"R... | null | null | null | no | We conclude that eosinophils accumulated in the airways by polymyxin-B does not affect release of chemical mediators induced by antigen or propranolol inhalation, or action of released mediators in vivo. |
Is expression of complement and toll-like receptor pathway genes associated with malaria severity in Mali : a pilot case control study? | [
"The host response to infection by Plasmodium falciparum, the parasite most often responsible for severe malaria, ranges from asymptomatic parasitaemia to death. The clinical trajectory of malaria is influenced by host genetics and parasite load, but the factors determining why some infections produce uncomplicated... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Biomarkers",
"Case-Control Studies",
"Child, Preschool",
"Cluster Analysis",
"Complement System Proteins",
"Female",
"Gene Expression Profiling",
"Humans",
"Infant",
"Malaria, Falciparum",
"Male",
"Mali",
"Molecular Epidemiology",
"Oligonucleotide Array Sequence Analysis",
"Pilot Projec... | null | null | null | yes | Overexpression of genes previously associated with uncomplicated malaria was associated with severe disease. Low baseline expression of these genes may represent candidate markers for severe malaria. Despite the small sample size, results of this pilot study offer promising targets for follow-up analyses. |
Does increased use of brachiocephalic arteriovenous fistulas improve functional primary patency? | [
"As vascular surgeons strive to meet the Fistula First Initiative, some authors have observed a decrease in arteriovenous fistula (AVF) maturation rates in association with an increase in AVF creation. In May 2012, we adopted a practice change in an attempt to maintain the same high level of AVF creation while lead... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Arm",
"Arteriovenous Shunt, Surgical",
"Brachial Artery",
"Female",
"Graft Occlusion, Vascular",
"Humans",
"Kidney Failure, Chronic",
"Male",
"Middle Aged",
"Renal Dialysis",
"Retrospective Studies",
"Vascular Patency",
"Veins"
] | null | null | null | yes | Increasing brachiocephalic AVF creation and reducing our reliance on radiocephalic AVFs resulted in a significant increase in primary functional patency at 1 year. This was achieved while maintaining the same high percentage of fistulas, a lower rate of central catheter infections, and the same low incidence of steal s... |
Do oocytes from women of advanced reproductive age appear to have an increased risk of zona pellucida hardening? | [
"To test the hypothesis that very advanced reproductive age leads to an increased risk of zona pellucida hardening by comparing fertilization rates and rates of failed fertilization with conventional oocyte insemination vs intracytoplasmic sperm injection (ICSI).",
"Women aged > or = 45 were given the option of I... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Embryo Transfer",
"Female",
"Fertilization in Vitro",
"Humans",
"Middle Aged",
"Oocytes",
"Pregnancy",
"Risk Assessment",
"Sperm Injections, Intracytoplasmic",
"Zona Pellucida"
] | null | null | null | no | Based on similar fertilization and failed fertilization rates in women aged > or = 45 undergoing IVF-ET, zona hardening does not appear to be a consequence of reproductive aging. |
Does pre-dinner administration increase the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients? | [
"A significant proportion of patients with connective tissue disease (CTD) have gastric esophageal reflux disease (GERD) symptoms despite receiving proton pump inhibitors (PPIs). Although pre-meal administration of PPIs is recommended in Western countries, the benefit of this administration timing in Japanese CTD p... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Connective Tissue Diseases",
"Drug Administration Schedule",
"Female",
"Gastroesophageal Reflux",
"Humans",
"Male",
"Meals",
"Middle Aged",
"Proton Pump Inhibitors",
"Quality of Life",
"Treatment Outcome"
] | null | null | null | yes | Pre-dinner administration of PPIs may increase their efficacy in Japanese CTD patients with GERD, especially those with overt symptoms. |
Do incontinent women have altered pelvic floor muscle contraction patterns? | [
"Pelvic floor exercises are invaluable for regaining continence but mechanisms are not fully understood. To contribute to the understanding of these mechanisms we investigated the contraction sequence of superficial vs deep pelvic floor muscles in 6 positions in continent and incontinent women.",
"The onset of co... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Electrodes",
"Electromyography",
"Female",
"Humans",
"Middle Aged",
"Muscle Contraction",
"Pelvic Floor",
"Reference Values",
"Statistics as Topic",
"Urinary Incontinence"
] | null | null | null | yes | Contractions of the superficial and deep pelvic floor muscles can be recorded by intravaginal or perineal electrodes. A consistent contraction sequence can be found in continent women but it is lacking in incontinent women. This might be a possible explanation for incontinence. Including differentiated muscle contracti... |
Is neuropsychological performance within-person variability associated with reduced treatment consent capacity? | [
"The capacity of older adults to make healthcare decisions is often impaired in dementia and has been linked to performance on specific neuropsychological tasks. Within-person across-test neuropsychological performance variability has been shown to predict future dementia. This study examined the relationship of wi... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Dementia",
"Executive Function",
"Female",
"Humans",
"Informed Consent",
"Male",
"Mental Competency",
"Neuropsychological Tests"
] | null | null | null | yes | These findings are consistent with an emerging construct of consent capacity in which discrete decisional abilities are differentially associated with cognitive processes and indicate that the sensitivity and accuracy of consent capacity assessments can be improved by evaluating decisional abilities separately. |
Is diurnal temperature range a risk factor for coronary heart disease death? | [
"Although the relation between day-to-day temperature change and coronary heart disease (CHD) mortality is well established, it is unknown whether temperature variation within 1 day, ie, diurnal temperature range (DTR), is an independent risk factor for acute CHD death.",
"We used time-series and case-crossover a... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"China",
"Circadian Rhythm",
"Coronary Disease",
"Humans",
"Risk Factors",
"Temperature"
] | null | null | null | yes | Our findings suggest that DTR is an independent risk factor for acute CHD death. |
Does cHFR promoter methylation indicate poor prognosis in stage II microsatellite stable colorectal cancer? | [
"Data on the prognostic significance of promoter CpG island methylation in colorectal cancer (CRC) are conflicting, possibly due to associations between methylation and other factors affecting survival such as genetic alterations and use of adjuvant therapy. Here, we examine the prognostic impact of promoter methyl... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Cell Cycle Proteins",
"Colorectal Neoplasms",
"CpG Islands",
"DNA Methylation",
"Female",
"Follow-Up Studies",
"Gene Expression Regulation, Neoplastic",
"Humans",
"Male",
"Microsatellite Instability",
"Middle Aged",
"Mutation",
"Neoplasm Proteins",
"Neoplasm Staging",
"Phenoty... | null | null | null | yes | CHFR promoter CpG island methylation, which is associated with MSI, also occurs frequently in MSS CRCs and is a promising prognostic marker in stage II, MSS, BRAF WT CRCs. |
Does stimulus conditioned to foot-shock stress reinstate alcohol-seeking behavior in an animal model of relapse? | [
"Stress and conditioned responses to drug cues have been implicated as critical factors in relapse to drug use. In the animal literature, both the conditioned effects of drug-related stimuli and the unconditioned effects of foot-shock stress have been well documented to reinstate extinguished drug-seeking behavior.... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Alcohol Drinking",
"Animals",
"Behavior, Addictive",
"Conditioning (Psychology)",
"Disease Models, Animal",
"Ethanol",
"Male",
"Rats",
"Rats, Wistar",
"Secondary Prevention",
"Stress, Physiological"
] | null | null | null | yes | The results confirm that both conditioned stress and ethanol cues elicit ethanol-seeking behavior and, more importantly, that these stimuli produce interactive effects resulting in an increased ethanol-seeking response. The findings also indicate that susceptibility to ethanol seeking induced by conditioned stress and ... |
Is postoperative pain after hip fracture procedure specific? | [
"Hip fracture patients experience high pain levels during postoperative rehabilitation. The role of surgical technique on postoperative pain has not been evaluated previously.",
"One hundred and seventeen hip fracture patients were included in a descriptive prospective study. All patients received continuous epid... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Analgesia, Epidural",
"Arthroplasty, Replacement, Hip",
"Bone Nails",
"Bone Screws",
"Female",
"Fracture Fixation, Internal",
"Fracture Fixation, Intramedullary",
"Hip Fractures",
"Humans",
"Male",
"Middle Aged",
"Pain Measurement",
"Pain, Postope... | null | null | null | yes | Postoperative pain levels after surgery for hip fracture are dependent on the surgical procedure, which should be taken into account in future studies of analgesia and rehabilitation. |
Does novel X-ray image noise reduction technology reduce patient radiation dose while maintaining image quality in coronary angiography? | [
"The consequences of high radiation dose for patient and staff demand constant improvements in X-ray dose reduction technology. This study assessed non-inferiority of image quality and quantified patient dose reduction in interventional cardiology for an anatomy-specific optimised cine acquisition chain combined wi... | [
"OBJECTIVE",
"METHODS"
] | [] | null | null | null | yes | This study demonstrates that the novel X-ray imaging technology provides non-inferior image quality compared with conventional angiographic systems for interventional cardiology with a 53 % patient dose reduction. |
Do clinical mesenchymal stromal cell products undergo functional changes in response to freezing? | [
"Current methods of mesenchymal stromal cell (MSC) cryopreservation result in variable post-thaw recovery and phenotypic changes caused by freezing. The objective of this investigation was to determine the influence of ex vivo cell expansion on phenotype of MSCs and the response of resulting phenotypes to freezing ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Apoptosis",
"Cell Count",
"Cell Cycle",
"Cell Proliferation",
"Cell Survival",
"Cryopreservation",
"Female",
"Freezing",
"Humans",
"Male",
"Mesenchymal Stem Cells"
] | null | null | null | yes | High pre-freeze senescence appears to correlate with poor post-thaw function in MSC samples, but additional studies are necessary to obtain a sample sizes large enough to quantify results. |
Is early neurologic examination reliable for prognostication in post-cardiac arrest patients who undergo therapeutic hypothermia? | [
"Recent advances in post-cardiac arrest (CA) care including therapeutic hypothermia (TH) have improved survival and favorable neurologic outcomes for survivors of CA. Survivors often present with deep coma and lack of brainstem reflexes, which are generally associated with adverse outcomes in many disease processes... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Cohort Studies",
"Emergency Service, Hospital",
"Female",
"Glasgow Coma Scale",
"Heart Arrest",
"Hospitalization",
"Humans",
"Hypothermia, Induced",
"Male",
"Middle Aged",
"Neurologic Examination",
"Reproducibility of Results",
"Treatment Outcome"
] | null | null | null | no | In this cohort of patients treated in a comprehensive postarrest care pathway that included TH, absence of neurologic function on initial ED presentation was not reliable for prognostication. Given these findings, clinicians should refrain from using the initial ED neurological examination to guide the aggressiveness o... |
Is complete revascularization a prerequisite for success in current transcatheter aortic valve implantation practice? | [
"This study sought to assess in patients undergoing transcatheter aortic valve implantation (TAVI), the prevalence and impact of incomplete coronary revascularization defined as >50% coronary artery or graft diameter stenosis on visual assessment of the coronary angiogram.",
"TAVI is an established treatment opti... | [
"OBJECTIVE",
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Aged",
"Aged, 80 and over",
"Aortic Valve Stenosis",
"Cardiac Catheterization",
"Chi-Square Distribution",
"Coronary Angiography",
"Coronary Artery Bypass",
"Coronary Stenosis",
"Female",
"Heart Valve Prosthesis Implantation",
"Humans",
"Kaplan-Meier Estimate",
"Logistic Models",
"Male",
... | null | null | null | no | In an elderly patient population undergoing TAVI for severe AS, a judicious revascularization strategy selection by a dedicated heart team can generate favorable mid-term outcome obviating the need for complete coronary revascularization. |
Does large-scale profiling of signalling pathways reveal an asthma specific signature in bronchial smooth muscle cells? | [
"Bronchial smooth muscle (BSM) cells from asthmatic patients maintain in vitro a distinct hyper-reactive (\"primed\") phenotype, characterized by increased release of pro-inflammatory factors and mediators, as well as hyperplasia and/or hypertrophy. This \"primed\" phenotype helps to understand pathogenesis of asth... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Asthma",
"Bronchi",
"Female",
"Gene Expression Profiling",
"Humans",
"Male",
"Middle Aged",
"Myocytes, Smooth Muscle",
"Signal Transduction",
"Transcriptome",
"Young Adult"
] | null | null | null | yes | These first-time results can now be exploited toward development of novel therapeutic strategies targeting ISP signatures linked to asthma pathophysiology. |
Does curcumin inhibit cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells? | [
"To investigate the protective effect and the possible mechanism of curcumin on anti-atherosclerosis.",
"Morphological changes of atherosclerotic lesions taken from apoE knockout (apoE-/-) mice were determined by hematoxylin- eosin staining. Intracellular lipid droplets and lipid levels were assayed by oil red O ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Caveolin 1",
"Cells, Cultured",
"Cholesterol",
"Curcumin",
"Dose-Response Relationship, Drug",
"Fluorescent Antibody Technique, Indirect",
"Mice",
"Mice, Inbred C57BL",
"Mice, Knockout",
"Muscle, Smooth, Vascular",
"Random Allocation",
"Rats",
"Signal Transduction",
"Sterol R... | null | null | null | yes | Curcumin inhibits ox-LDL-induced cholesterol accumulation in cultured VSMC through increasing the caveolin-1 expression via the inhibition of nuclear translocation of SREBP-1. |
Does hemoglobin Raleigh result in factitiously low hemoglobin A1c when evaluated via immunoassay analyzer? | [
"Glycosylated hemoglobin (HbA1c) is commonly used to assess long-term blood glucose control in patients with diabetes mellitus. Numerous conditions including hemoglobinopathies can alter HbA1c measurements and cause misleading results.",
"To report a 13-year-old male with Type 1 diabetes mellitus who had low HbA1... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Amino Acid Sequence",
"Diabetes Mellitus, Type 1",
"Electrophoresis",
"False Negative Reactions",
"Glycated Hemoglobin A",
"Hemoglobins, Abnormal",
"Humans",
"Immunoassay",
"Male",
"Sequence Analysis, DNA",
"Spectrometry, Mass, Electrospray Ionization",
"Tandem Mass Spectromet... | null | null | null | yes | In managing diabetic patients, knowledge of hemoglobinopathies influencing HbA1c determination methods is essential because hemoglobin variants may cause mismanagement of diabetes. Unusual results should prompt further analysis for a hemoglobinopathy as the potential cause of aberrant results. |
Does high-quality chronic care delivery improve experiences of chronically ill patients receiving care? | [
"Investigate whether high-quality chronic care delivery improved the experiences of patients.",
"This study had a longitudinal design.",
"We surveyed professionals and patients in 17 disease management programs targeting patients with cardiovascular diseases, chronic obstructive pulmonary disease, heart failure... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Aged, 80 and over",
"Cardiovascular Diseases",
"Chronic Disease",
"Feeding and Eating Disorders",
"Female",
"Heart Failure",
"Humans",
"Male",
"Middle Aged",
"Netherlands",
"Patient Satisfaction",
"Pulmonary Disease, Chronic Obstructive",
"Quality of Hea... | null | null | null | yes | This research showed that care quality and changes therein predict more positive experiences of patients with various chronic conditions over time. |
Does methylphenidate treatment affect mitogen-activated protein kinase activation in the striatum of young rats? | [
"Methylphenidate (MPD) is a drug prescribed for the treatment of attention deficit/hyperactivity disorder and its therapeutic effect is attributed to the inhibition of dopamine.",
"Young male Wistar rats were administered MPD (1, 2, 5, or 10 mg/kg) once a day or an intraperitoneal injection of saline for 28 days ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [] | null | null | null | yes | The alteration in the level of activation of mitogen-activated protein kinases can be a molecular mechanism through which MPD exerts its therapeutic effect. |
Does a decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflect reduced skin blood flow? | [
"Spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation (ScO2) is reduced with administration of phenylephrine, while cerebral blood flow may remain unaffected. We hypothesized that extracranial vasoconstriction explains the effect of phenylephrine on ScO2.",
"We measured ScO2 an... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Algorithms",
"Blood Pressure",
"Carotid Artery, External",
"Frontal Lobe",
"Heart Rate",
"Humans",
"Linear Models",
"Male",
"Middle Cerebral Artery",
"Oxygen Consumption",
"Phenylephrine",
"Regional Blood Flow",
"Skin",
"Spectroscopy, Near-Infrared",
"Vascular Resistance",
"Vasoconstr... | null | null | null | yes | These findings suggest that a phenylephrine-induced decrease in ScO2, as determined by INVOS-4100 near-infrared spectroscopy, reflects vasoconstriction in the extracranial vasculature rather than a decrease in cerebral oxygenation. |
Is cardiac mortality higher around Christmas and New Year 's than at any other time : the holidays as a risk factor for death? | [
"Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors.",
"We fitted a locally weighted polynomial regression line to daily mortali... | [
"BACKGROUND",
"RESULTS"
] | [] | null | null | null | yes | Our findings suggest that the Christmas/New Year's holidays are a risk factor for cardiac and noncardiac mortality. There are multiple explanations for this association, including the possibility that holiday-induced delays in seeking treatment play a role in producing the twin holiday spikes. |
Does sleep restriction decrease the physical activity of adults at risk for type 2 diabetes? | [
"To test the hypothesis that recurrent sleep curtailment will result in decreased physical activity in adults at risk for type 2 diabetes.",
"Two-condition 2-period randomized crossover study.",
"University General Clinical Research Center.",
"Eighteen healthy patients with parental history of type 2 diabetes... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Affect",
"Cross-Over Studies",
"Diabetes Mellitus, Type 2",
"Exercise",
"Female",
"Humans",
"Male",
"Motor Activity",
"Polysomnography",
"Sleep",
"Sleep Deprivation",
"Young Adult"
] | null | null | null | yes | Experimental sleep restriction results in decreased amount and intensity of physical activity in adults at risk for type 2 diabetes. |
Is promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy? | [
"To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) genes are associated with type of diabetes or presence of diabetic retinopathy.",
"A total of 334 typ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Diabetes Mellitus, Type 2",
"Diabetic Retinopathy",
"Genetic Loci",
"Genetic Predisposition to Disease",
"Genetic Testing",
"Genotype",
"Humans",
"Lymphotoxin-alpha",
"Polymorphism, Single Nucleotide",
"Promoter Regions, Genetic",
"Tumor Necrosis Factor-alpha"
] | null | null | null | yes | An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes. |
Does eating in the absence of hunger during childhood predict self-reported binge eating in adolescence? | [
"The objectives of the current study were to examine whether eating in the absence of hunger (EAH) at age 7 predicted reports of self-reported binge eating at age 15 and to identify factors among girls with high-EAH that moderated risk of later binge eating.",
"Subjects included 158 girls assessed at age 7 and ag... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Anxiety",
"Body Image",
"Body Mass Index",
"Body Weight",
"Bulimia",
"Child",
"Depression",
"Diet",
"Eating",
"Emotions",
"Feeding Behavior",
"Female",
"Humans",
"Hunger",
"Logistic Models",
"Obesity",
"Self Report"
] | null | null | null | yes | EAH during childhood predicted reports of binge eating during adolescence; girls with elevated BMI, negative affect, and maladaptive eating- and weight-related cognitions were at increased risk. High-EAH in childhood may be useful for indicating those at risk for developing binge eating. |
Does use of a novel polyp `` ruler snare '' improve estimation of colon polyp size? | [
"Prior studies have demonstrated that endoscopists' estimates of polyp size are imprecise. The aim of this study was to determine whether a modified polypectomy \"ruler snare\" improves the accuracy of assessment of polyp size in real time without the use of additional devices.",
"Ten artificial polyps of predete... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Colonic Polyps",
"Colonoscopy",
"Dimensional Measurement Accuracy",
"Equipment Design",
"Humans",
"Tumor Burden"
] | null | null | null | yes | The modified ruler snare improved polyp size assessment compared with a standard snare, particularly with large polyps. Overall, although size estimation continues to be imprecise, the addition of calibrated markings to a polypectomy snare is a simple and likely low-cost means to improve neoplasia surveillance recommen... |
Do mathematical models to predict long bone lengths by transvaginal scan at 11-16 weeks ' gestation? | [
"To propose a new mathematical model to estimate the length of fetal long bones in early pregnancy that can be used in the routine clinical setting.",
"In a group of 400 singleton normal fetuses, referred for transvaginal ultrasound examination between 11 and 16 weeks' gestation prior to genetic amniocentesis, a ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Bone Diseases",
"Bone and Bones",
"Female",
"Fetal Diseases",
"Gestational Age",
"Humans",
"Models, Biological",
"Pregnancy",
"Ultrasonography, Prenatal"
] | null | null | null | yes | Our proposed two linear models had a very good ability to estimate FL and HL and, due to the simplicity of the calculations, would be particularly useful in the routine clinical setting. |
Does [ The active metabolite of leflunomide A771726 inhibit proliferation and collagen synthesis of hepatic stellate cell ]? | [
"To investigate the effect of the metabolite of leflunomide, A771726,on proliferation and collagen synthesis of hepatic stellate cell (HSC).",
"HSC and Kupffer cells were isolated from the rat liver by collagenase IV and pronase perfusion, and purified by density gradient separation. The effects of A771726 on cel... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aniline Compounds",
"Animals",
"Carbon Tetrachloride",
"Cell Division",
"Cells, Cultured",
"Collagen Type I",
"Hepatocytes",
"Hydroxybutyrates",
"Immunosuppressive Agents",
"Interleukin-1",
"Isoxazoles",
"Kupffer Cells",
"Leflunomide",
"Male",
"Rats",
"Rats, Sprague-Dawley",
"Transf... | null | null | null | yes | A771726 has markedly inhibitory effect on proliferation and collagen synthesis of HSC and secretion of TGF-beta,TNF-alpha and IL-1 from Kupffer cells. |
Does reduced NO-cGMP signaling contribute to vascular inflammation and insulin resistance induced by high-fat feeding? | [
"Diet-induced obesity (DIO) in mice causes vascular inflammation and insulin resistance that are accompanied by decreased endothelial-derived NO production. We sought to determine whether reduced NO-cGMP signaling contributes to the deleterious effects of DIO on the vasculature and, if so, whether these effects can... | [
"OBJECTIVE",
"RESULTS"
] | [
"Animals",
"Aorta, Thoracic",
"Aortic Diseases",
"Cell Adhesion Molecules",
"Cells, Cultured",
"Cyclic GMP",
"Cyclic Nucleotide Phosphodiesterases, Type 5",
"Dietary Fats",
"Disease Models, Animal",
"Down-Regulation",
"Endothelial Cells",
"Enzyme Inhibitors",
"Humans",
"I-kappa B Kinase",
... | null | null | null | yes | Reduced signaling via the NO-cGMP pathway is a mediator of vascular inflammation and insulin resistance during overnutrition induced by high-fat feeding. Therefore, phosphodiesterase-5, soluble guanylyl cyclase, and other molecules in the NO-cGMP pathway (eg, protein kinase G) constitute potential targets for the treat... |
Are nADPH oxidase ( NOX ) isoforms inhibited by celastrol with a dual mode of action? | [
"Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory conditions, and shows benefits in models of neurodegenerative disease, cancer and arthritis, although its mechanism of action is incompletely understood.",
"Celastrol... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Animals",
"CHO Cells",
"Cell Line",
"Cell Line, Transformed",
"Cricetinae",
"Cytosol",
"HEK293 Cells",
"Humans",
"Hydrogen Peroxide",
"NADPH Oxidases",
"Neutrophils",
"Onium Compounds",
"Oxidoreductases",
"Oxygen",
"Protein Binding",
"Protein Isoforms",
"Protein Transport",
"React... | null | null | null | yes | These results demonstrate that celastrol is a potent inhibitor of NOX enzymes in general with increased potency against NOX1 and NOX2. Furthermore, inhibition of NOX1 and NOX2 was mediated via a novel mode of action, namely inhibition of a functional association between cytosolic subunits and the membrane flavocytochro... |
Are plasma concentrations of afamin associated with the prevalence and development of metabolic syndrome? | [
"Afamin is a human plasma vitamin E-binding glycoprotein primarily expressed in the liver and secreted into the bloodstream. Because little is known about (patho)-physiological functions of afamin, we decided to identify phenotypes associated with afamin by investigating transgenic mice overexpressing the human afa... | [
"BACKGROUND",
"RESULTS"
] | [
"Adult",
"Aged",
"Animals",
"Blood Glucose",
"Body Weight",
"Carrier Proteins",
"Databases, Factual",
"Female",
"Follow-Up Studies",
"Glycoproteins",
"Humans",
"Logistic Models",
"Male",
"Metabolic Syndrome",
"Mice",
"Mice, Transgenic",
"Middle Aged",
"Odds Ratio",
"Phenotype",
... | null | null | null | yes | This study in transgenic mice and >5000 participants in epidemiological studies shows that afamin is strongly associated with the prevalence and development of metabolic syndrome and all its components. |
Is coincident pre-diabetes associated with dysregulated cytokine responses in pulmonary tuberculosis? | [
"Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.",
"To identify the influence of coincident PDM on cytokine levels in PTB, we exam... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Cytokines",
"Female",
"Humans",
"Male",
"Middle Aged",
"Prediabetic State",
"Tuberculosis, Pulmonary",
"Young Adult"
] | null | null | null | yes | Our data reveal that pre-diabetes in PTB individuals is characterized by heightened cytokine responsiveness, indicating that a balanced pro and anti - inflammatory cytokine milieu is a feature of pre-diabetes--TB co-morbidity. |
Is early brain pseudoatrophy while on natalizumab therapy due to white matter volume changes? | [
"Investigation of atrophy data from a pivotal natalizumab trial has demonstrated an increased rate of volume loss, compared to placebo, after the first year of therapy. It was considered to be probably due to a pseudoatrophy effect.",
"To assess grey and white matter volume changes and their relation to global br... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Antibodies, Monoclonal, Humanized",
"Atrophy",
"Brain",
"Diagnosis, Differential",
"Female",
"Humans",
"Image Interpretation, Computer-Assisted",
"Magnetic Resonance Imaging",
"Male",
"Multiple Sclerosis, Relapsing-Remitting",
"Natalizumab",
"Nerve Fibers, Myelinated"
] | null | null | null | yes | Early brain volume loss during natalizumab therapy is mainly due to WMF volume loss and it is related to the inflammatory activity present at the onset of therapy. We found that the pseudoatrophy effect is mostly due to white matter volume changes. |
Are patients with chronic heart failure encountered in daily clinical practice different from the `` typical '' patient enrolled in therapeutic trials? | [
"The aim of this study was to compare the clinical characteristics of patients enrolled in randomized clinical trials on congestive heart failure treatment with those of real-world patients encountered in daily clinical practice.",
"We searched the Cochrane review methodology, Medline and SilverPlatter databases ... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [] | null | null | null | yes | Our data suggest that most clinical trials on congestive heart failure, on which the guidelines for clinical practice are based, have generally included patients who are not representative of the whole spectrum of patients actually managed in clinical practice. |
Is reduction of albumin urinary excretion associated with reduced cardiovascular events in hypertensive and/or diabetic patients . A meta-regression analysis of 32 randomized trials? | [
"The association between renal dysfunction and risk of cardiovascular (CV) events and mortality has been reported in several studies. However, it is unclear whether reduction in urinary albumin excretion (UAE) is associated with reduced risk of clinical events. Therefore, we sought to investigate, in a meta-regress... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Albuminuria",
"Biomarkers",
"Cardiovascular Diseases",
"Cause of Death",
"Diabetes Mellitus",
"Humans",
"Hypertension",
"Randomized Controlled Trials as Topic",
"Regression Analysis",
"Risk"
] | null | null | null | yes | Reduction in UAE is associated with reduced risk of MI and stroke in diabetic and/or hypertensive patients. These findings suggest that UAE changes may represent a valuable intermediate end-point for CV risk evaluation in clinical practice. |
Does ultrasonic tissue characterization predict left ventricular remodeling in patients with acute anterior myocardial infarction after primary coronary angioplasty? | [
"The aim of this study was to assess the role of cyclic variation (CV) of myocardial integrated backscatter (IBS) in the prediction of left ventricular (LV) remodeling in patients with anterior acute myocardial infarction (AMI) after primary coronary angioplasty.",
"Some studies have shown that the CV of myocardi... | [
"OBJECTIVE",
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Angioplasty, Balloon, Coronary",
"Female",
"Humans",
"Male",
"Middle Aged",
"Myocardial Infarction",
"Prognosis",
"Risk Assessment",
"Risk Factors",
"Treatment Outcome",
"Ultrasonography",
"Ventricular Dysfunction, Left",
"Ventricular Remodeling"
] | null | null | null | yes | Myocardial IBS, especially NTD, is useful for predicting LV remodeling in patients with AMI after primary coronary angioplasty. |
Is [ Expression of programmed cell death 4 protein closely correlated with laryngeal squamous cell carcinomas ]? | [
"To study whether programmed cell death 4 (PDCD4) is involved in the development and progression of laryngeal squamous cell carcinomas (LSCC).",
"The expressions of PDCD4 protein were examined by immunohistochemical staining and Western blot in LSCC tissues and their surrounding laryngeal normal mucosa tissues.",... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Apoptosis Regulatory Proteins",
"Carcinoma, Squamous Cell",
"Female",
"Humans",
"Immunohistochemistry",
"Laryngeal Neoplasms",
"Male",
"Middle Aged",
"Prognosis",
"RNA-Binding Proteins"
] | null | null | null | yes | The low expression of PDCD4 protein is closely related to the development and progression of LSCC. PDCD4 might be a novel molecular marker for prognosticating metastases and prognosis of LSCC. |
Does stable-State Midrange-Proadrenomedullin Level be a Strong Predictor of Mortality in Patients With COPD? | [
"Midrange-proadrenomedullin (MR-proADM) has been shown to be elevated in patients hospitalized for an acute exacerbation of COPD (AECOPD) and in patients with community-acquired pneumonia. When measured during AECOPDs, MR-proADM has also been shown to be a predictor of mortality. We hypothesized that MR-proADM leve... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adrenomedullin",
"Aged",
"Female",
"Humans",
"Male",
"Middle Aged",
"Mortality",
"Netherlands",
"Patient Acuity",
"Peptide Fragments",
"Predictive Value of Tests",
"Prognosis",
"Protein Precursors",
"Pulmonary Disease, Chronic Obstructive",
"Reproducibility of Results",
"Sputum"
] | null | null | null | yes | MR-proADM measured in the stable state appeared to be a strong predictor of mortality in patients with COPD. MR-proADM is far easier to measure than other predictors of mortality in COPD, such as BMI, airflow obstruction, dyspnea, and exercise capacity score. |
Does adenovirus-mediated Bak gene transfer induce apoptosis in mesothelioma cell lines? | [
"Conventional treatment for mesothelioma is largely ineffective. We therefore evaluated the novel approach of adenoviral gene transfer of the proapoptotic Bcl-2 family member Bak in mesothelioma cancer cell lines, which are sensitive and resistant to adenoviral p53.",
"Binary adenoviral Bak (Ad/GT-Bak and Ad/GV16... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adenoviridae",
"Apoptosis",
"Blotting, Western",
"Cell Survival",
"Flow Cytometry",
"Gene Expression",
"Genetic Vectors",
"Humans",
"Membrane Proteins",
"Mesothelioma",
"Mutation",
"Pleural Neoplasms",
"Transduction, Genetic",
"Tumor Cells, Cultured",
"Tumor Suppressor Protein p53",
"... | null | null | null | yes | Adenovirus-mediated overexpression of the Bak gene induces apoptosis and decreased cellular viability in p53-sensitive and p53-resistant mesothelioma cells. These data suggest that the gene transfer of proapoptotic Bcl-2 family members may represent a novel gene therapy strategy to treat mesothelioma. |
Do patients with severe obstructive sleep apnea syndrome and elevated high-sensitivity C-reactive protein need priority treatment? | [
"To evaluate the clinical factors predicting the significantly elevated high-sensitivity C-reactive protein (hs-CRP) concentrations, defined herein as hs-CRP > or = 3 mg/L, in adult males with untreated obstructive sleep apnea syndrome (OSAS).",
"Cross-sectional study.",
"Tertiary referral center.",
"Sixty-fi... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Biomarkers",
"Body Mass Index",
"C-Reactive Protein",
"Cohort Studies",
"Coronary Disease",
"Cross-Sectional Studies",
"Humans",
"Male",
"Middle Aged",
"Needs Assessment",
"Polysomnography",
"Predictive Value of Tests",
"Risk Factors",
"Severity of Illness Index",
"Sleep Apne... | null | null | null | yes | Patients in this study with hs-CRP > or = 3 mg/L were more prevalent in the severe OSAS group. This observation suggests that the severe OSAS patients need to have their cardiovascular statuses evaluated by use of an hs-CRP screening test. |
Does religious activity improve life satisfaction for some physicians and older patients? | [
"To assess religious perceptions and activities of physicians and older patients and to determine whether religious activities are associated with life satisfaction.",
"A cross-sectional survey of practicing Virginia internists and psychiatrists and hospitalized or institutionalized (nursing home) older adults.",... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adaptation, Psychological",
"Aged",
"Cross-Sectional Studies",
"Female",
"Health Knowledge, Attitudes, Practice",
"Humans",
"Inpatients",
"Internal Medicine",
"Life Change Events",
"Male",
"Middle Aged",
"Nursing Homes",
"Personal Satisfaction",
"Physicians",
"Predictive Value of Tests"... | null | null | null | yes | Intrinsic religious activity is associated positively with life satisfaction in physicians and ill older adults. |
Does e-cadherin protein expression predict prostate cancer salvage radiotherapy outcomes? | [
"Radiotherapy for biochemical prostate cancer recurrence after prostatectomy achieves durable salvage rates of only 40% to 50%. Improved methods of identifying patients unlikely to benefit from salvage radiotherapy are needed. Altered expression of the adhesion molecule E-cadherin may be associated with the invasiv... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Cadherins",
"Follow-Up Studies",
"Humans",
"Male",
"Middle Aged",
"Predictive Value of Tests",
"Prostate-Specific Antigen",
"Prostatectomy",
"Prostatic Neoplasms",
"Salvage Therapy",
"Treatment Outcome"
] | null | null | null | yes | Aberrant E-cadherin staining is associated with increased biochemical failure rates after salvage radiotherapy. Patients with biochemical failure after prostatectomy and aberrant E-cadherin expression are likely to have subclinical disseminated disease. Early systemic therapy may be warranted in these patients. |
Does transoral laser microsurgery elevate fundamental frequency in early glottic cancer? | [
"To evaluate the long-term voice characteristics and quality of life of early glottic cancer patients after definitive treatment.",
"Case series with chart review in a tertiary care medical center in Taiwan.",
"Forty-two consecutive patients who received radiation therapy (RT) or transoral laser microsurgery (T... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Communication",
"Disability Evaluation",
"Female",
"Glottis",
"Humans",
"Laryngeal Neoplasms",
"Laser Therapy",
"Male",
"Microsurgery",
"Middle Aged",
"Neoplasm Staging",
"Phonation",
"Predictive Value of Tests",
"Quality of Life",
"Radiation ... | null | null | null | yes | Male patients who received TLM have higher modal fundamental frequency than male patients who received RT and norms. Voice-related life quality is similar in patients regardless of RT or TLM treatment for early glottic cancer, but those who receive TLM have better communication abilities than those who receive RT. |
Does the endogenous NOS inhibitor asymmetric dimethylarginine ( ADMA ) predict LV mass independent of afterload? | [
"Nitric oxide (NO) is a modulator of left ventricular hypertrophy (LVH) and myocardial relaxation. The impact of NO availability on development of LVH has never been demonstrated in humans. We tested the hypotheses that elevation of asymmetric dimethylarginine (ADMA) concentrations (biochemical marker of decreased ... | [
"BACKGROUND",
"RESULTS"
] | [
"Aged",
"Aged, 80 and over",
"Arginine",
"Blood Pressure",
"Echocardiography",
"Female",
"Humans",
"Hypertrophy, Left Ventricular",
"Magnetic Resonance Imaging",
"Male",
"Middle Aged",
"Multivariate Analysis",
"Myocardium",
"Nitric Oxide",
"Nitric Oxide Synthase",
"Predictive Value of ... | null | null | null | yes | These data imply that NO bioavailability within the myocardium modulates earliest stages of LVH development and facilitates development of diastolic dysfunction at a given LV mass. |
Does proprioceptive neck influence modify the information about tilt direction coded by the cerebellar anterior vermis? | [
"To verify whether the direction of head tilt coded by the population response of Purkinje (P) cells located in the cerebellar anterior vermis is modified by the relative position of the body with respect to the head.",
"In decerebrate cats, the responses of P cells to wobble of the whole animal were analyzed in ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Cats",
"Decerebrate State",
"Head Movements",
"Neck Muscles",
"Proprioception",
"Purkinje Cells",
"Tilt-Table Test"
] | null | null | null | yes | We propose that information from neck receptors regulates the convergence of labyrinthine signals with different spatial and temporal properties on corticocerebellar units, thus allowing the P-cell population to code the direction of body tilt. |
Is the `` second gas effect '' a valid concept? | [
"To determine whether the \"second gas effect\" is valid, we determined the pharmacokinetics of 0.2% enflurane with or without 80% N2) (n = 7 each) under controlled constant volume ventilation in 14 young healthy male patients before their operations. The alveolar (end-tidal) concentration (FA) and inspired concent... | [
"UNLABELLED"
] | [
"Adult",
"Anesthesia, General",
"Anesthetics, Inhalation",
"Dose-Response Relationship, Drug",
"Enflurane",
"Humans",
"Male",
"Nitrous Oxide",
"Pulmonary Alveoli"
] | null | null | null | no | We studied the effects of N2O on the ratio of alveolar (end-tidal) concentration to inspired concentration of the second gas (enflurane) and on its blood concentration in humans. Nitrous oxide did not affect the alveolar or blood concentration of the second gas under controlled constant volume ventilation. The "second ... |
Does new genotyping method discover sustained nosocomial Pseudomonas aeruginosa outbreak in an intensive care burn unit? | [
"Pseudomonas aeruginosa is a leading cause of healthcare-associated infections in the intensive care unit (ICU).",
"To investigate an unexplained increase in the incidence of P. aeruginosa recovered from clinical samples in the ICU over a two-year period.",
"After unsuccessful epidemiological investigation by c... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Burn Units",
"Child, Preschool",
"Cross Infection",
"Disease Outbreaks",
"Environmental Microbiology",
"Epidemiological Monitoring",
"Female",
"Genotype",
"Humans",
"Infection Control",
"Intensive Care Units",
"Male",
"Middle Aged",
"Molecular E... | null | null | null | yes | The use of a novel DLST method allowed the genotyping of a large number of clinical and environmental isolates, leading to the identification of the environmental source of a large unrecognized outbreak in the burn unit. Eradication of the outbreak was confirmed after implementation of a continuous epidemiological surv... |
Do multiple microRNAs regulate human FOXP2 gene expression by targeting sequences in its 3 ' untranslated region? | [
"Mutations in the human FOXP2 gene cause speech and language impairments. The FOXP2 protein is a transcription factor that regulates the expression of many downstream genes, which may have important roles in nervous system development and function. An adequate amount of functional FOXP2 protein is thought to be cri... | [
"BACKGROUND",
"RESULTS"
] | [
"3' Untranslated Regions",
"Base Sequence",
"Binding Sites",
"Cerebellum",
"Down-Regulation",
"Fetus",
"Forkhead Transcription Factors",
"Gene Expression Regulation",
"Gene Expression Regulation, Developmental",
"Humans",
"MicroRNAs",
"RNA, Messenger"
] | null | null | null | yes | Our results reveal novel regulatory functions of the human FOXP2 3' UTR sequence and regulatory interactions between multiple miRNAs and the human FOXP2 gene. The expression of let-7a, miR-9, and miR-129-5p in the human fetal cerebellum is consistent with their roles in regulating FOXP2 expression during early cerebell... |
Is traditional dietary pattern of South America linked to breast cancer : an ongoing case-control study in Argentina? | [
"Several studies have shown the effect of dietary patterns on breast cancer risk, but none has been conducted in Argentina. The aim of this study was to extract dietary patterns from Food Frequency Questioner, to estimate their effect on breast cancer occurrence while taking into account aggregation factors (family... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Aged",
"Argentina",
"Body Mass Index",
"Breast Neoplasms",
"Case-Control Studies",
"Culture",
"Diet",
"Dietary Carbohydrates",
"Dietary Fats",
"Energy Intake",
"Exercise",
"Female",
"Food",
"Fruit",
"Humans",
"Meat",
"Menopause",
"Middle Aged",
"Plant Oils",
"Risk Factors",
... | null | null | null | yes | While the Prudent pattern was associated with a reduced risk of BC, Traditional, Rural and Starchy patterns showed a promoting effect. Despite the threats to validity, the nature of associations was not strongly affected. |
Is dementia strongly associated with 90-day mortality in lobar cerebral amyloid angiopathy related intra-cerebral haemorrhage? | [
"While evidence suggests that lobar intracerebral haemorrhage (ICH) is linked with dementia and cognitive impairment, the association between cognition and mortality risk from ICH is unclear.",
"To examine the association between dementia or cognitive impairment and short- and medium-term mortality post ICH.",
... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Aged, 80 and over",
"Cerebral Amyloid Angiopathy",
"Cerebral Hemorrhage",
"Cognition Disorders",
"Dementia",
"Female",
"Follow-Up Studies",
"Frontal Lobe",
"Glasgow Coma Scale",
"Humans",
"Male",
"Middle Aged",
"Retrospective Studies",
"Risk Factors",
"Time Factors"... | null | null | null | yes | A history of dementia or cognitive impairment is more common in lobar CAA-related ICH and it is a medium-term mortality predictor in lobar ICH but not in deep non-lobar ICH. |
Does periodontal treatment need in a native island community in Colombia determined with CPITN? | [
"To identify the prevalence and different degrees of periodontal disease in an isolated community (Isla Grande, Colombia) with no dental services and low educational level with the use of CPITN, and to establish periodontal treatment needs in different age groups.",
"Of 116 people examined, 0.9% were in periodont... | [
"OBJECTIVE",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Age Factors",
"Aged",
"Child",
"Colombia",
"Dental Calculus",
"Female",
"Gingival Hemorrhage",
"Humans",
"Male",
"Middle Aged",
"Needs Assessment",
"Periodontal Diseases",
"Periodontal Pocket",
"Population Groups",
"Prevalence"
] | null | null | null | yes | This study shows that 81% of the sample has some type of periodontal treatment need, with 69.8% of them requiring periodontal treatment that may be supplied by a hygienist and 11.2% requiring specialised treatment. Implementation of oral health education and oral prevention programmes was recommended to the authorities... |
Does the traditional Japanese medicine hangeshashinto alleviate oral ulcer-induced pain in a rat model? | [
"Recent studies have demonstrated that mouthwash made with the traditional Japanese medicine hangeshashinto exhibits anti-inflammatory action and alleviates oral mucositis scores, including pain complaints, in patients undergoing chemoradiotherapy. However, no study has demonstrated the mechanism underlying how han... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Acetic Acid",
"Administration, Topical",
"Analgesics",
"Animals",
"Disease Models, Animal",
"Drugs, Chinese Herbal",
"Hypersensitivity",
"Indomethacin",
"Japan",
"Lidocaine",
"Male",
"Mouth Mucosa",
"Mouthwashes",
"Oral Ulcer",
"Pain",
"Random Allocation",
"Rats",
"Rats, Wistar",
... | null | null | null | yes | Hangeshashinto leads to long-lasting analgesic effects, specifically in the ulcer region by destroying the epithelial barrier. Hangeshashinto alleviates oral ulcer-induced pain in inflammation-dependent and/or independent manner. |
Are coagulofibrinolytic changes after isolated head injury different from those in trauma patients without head injury? | [
"To test the hypothesis that tissue factor release, thrombin activation, fibrin formation, and fibrinolysis after an isolated head injury are equal to those in patients without head injury, as well as to investigate the precise time course of the coagulation and fibrinolytic abnormalities after head injury, we perf... | [
"BACKGROUND",
"RESULTS"
] | [
"Adult",
"Blood Coagulation",
"Craniocerebral Trauma",
"Female",
"Fibrinolysis",
"Humans",
"Male",
"Prospective Studies",
"Retrospective Studies",
"Wounds and Injuries"
] | null | null | null | no | We systematically elucidated the time course of coagulation and fibrinolysis after isolated head injury. We further demonstrated that changes in coagulofibrinolytic and antifibrinolytic systems in patients with isolated head injury are not different from those in patients without head injury. |
Does anaphase lagging mainly explain chromosomal mosaicism in human preimplantation embryos? | [
"Cleavage stage embryos as well as postimplantation embryos have been studied extensively over the years. However, our knowledge with respect to the chromosomal constitution of human embryos at the blastocyst stage is still rudimentary.",
"In the present paper, a large series of human blastocysts was examined by ... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Anaphase",
"Blastocyst",
"Chromosomes, Human",
"Cleavage Stage, Ovum",
"Female",
"Fertilization in Vitro",
"Humans",
"In Situ Hybridization, Fluorescence",
"Karyotyping",
"Male",
"Mosaicism",
"Pregnancy",
"Sperm Injections, Intracytoplasmic"
] | null | null | null | yes | Anaphase lagging appeared to be the major mechanism through which human embryos acquire a mosaic chromosome pattern during preimplantation development to the blastocyst stage. |
Does cyanidin-3-O-beta-glucoside inhibit LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells? | [
"As a common phytochemical, cyanidin 3-O-beta-glucoside (C3G) has a role in inhibiting inflammatory mediators; however, its mechanism of action remains unclear. The purpose of this study was to explore the effect of C3G on lipopolysaccharide (LPS)-stimulated TNFalpha and IL-6 expression in the human monocyte/macrop... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Anthocyanins",
"Anti-Inflammatory Agents",
"Cell Line",
"Dose-Response Relationship, Drug",
"Gene Expression",
"Glucosides",
"Humans",
"I-kappa B Proteins",
"Inflammation Mediators",
"Interleukin-6",
"Lipopolysaccharides",
"Macrophages",
"NF-kappa B",
"Nitriles",
"Phosphorylation",
"S... | null | null | null | yes | Our results suggest that C3G exerts its anti-inflammatory effect through inhibiting IkappaBalpha phosphorylation, thereby suppressing NF-kappaB activity in THP-1 cells. |
Does production of IL1-beta by ovarian cancer cells induce mesothelial cell beta1-integrin expression facilitating peritoneal dissemination? | [
"A crucial step in the metastatic spread of ovarian cancer (OC) is the adhesion and implantation of tumor cells to the peritoneal mesothelium. In order to study this step in the cascade, we derived a pro-metastatic human ovarian carcinoma cell line (MFOC3) from the non-metastatic FOC3 line.",
"Molecular profiling... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [] | null | null | null | yes | These results suggest that a IL-1β/β1-integrin axis plays a role in ovarian tumor cell adhesion to mesothelia, a crucial step in ovarian cancer dissemination. |
Is retinal sensitivity a valuable complementary measurement to visual acuity -- a microperimetry study in patients with maculopathies? | [
"To evaluate changes in macular sensitivity, as measured with microperimetry, among patients with maculopathy and stable visual acuity (VA).",
"Macular sensitivity was assessed using the Spectral OCT/SLO™ microperimetry (OCT/SLO, Optos Plc., Dunfermline, UK) in 25 eyes (16 patients) with maculopathy and stable VA... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Contrast Sensitivity",
"Female",
"Humans",
"Male",
"Middle Aged",
"Prospective Studies",
"Retina",
"Retinal Diseases",
"Tomography, Optical Coherence",
"Visual Acuity",
"Visual Field Tests",
"Visual Fields"
] | null | null | null | yes | Point-to-point change in macular sensitivity can be used as a biomarker of changes in disease activity in patients with maculopathy, and can be more accurate than either mean sensitivity or BCVA in detection of changes in macular function. The measurement variability should be considered when observing the local sensit... |
Does obesity have no effect on outcomes following unicompartmental knee arthroplasty? | [
"Although obesity has historically been described as a contraindication to UKA, improved outcomes with modern UKA implant designs have challenged this perception. The purpose of this study was to assess the influence of obesity on the outcomes of UKA with a robotic-assisted system at a minimum follow-up of 24 month... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Arthroplasty, Replacement, Knee",
"Comorbidity",
"Female",
"Humans",
"Male",
"Middle Aged",
"Obesity",
"Osteoarthritis, Knee",
"Postoperative Period",
"Reoperation",
"Robotic Surgical Procedures",
"Treatment Outcome"
] | null | null | null | yes | These findings suggest that BMI does not influence clinical outcomes and readmission rates of robotic-assisted UKA at mid-term. The classic contraindication of BMI >30 kg/m |
Are the mitogen-activated protein kinases p38 and ERK1/2 increased in lesional psoriatic skin? | [
"Alterations in specific signal transduction pathways may explain the hyperproliferation and abnormal differentiation of the keratinocytes as well as the increased expression of inflammatory cytokines seen in psoriasis. Major signalling pathways used by eukaryotic cells to transduce extracellular signals into cellu... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Cells, Cultured",
"Humans",
"Isoenzymes",
"Mitogen-Activated Protein Kinase 1",
"Mitogen-Activated Protein Kinase 3",
"Mitogen-Activated Protein Kinases",
"Phosphorylation",
"Psoriasis",
"Skin",
"p38 Mitogen-Activated Protein Kinases"
] | null | null | null | yes | Taken together, our results demonstrate that the activity of the MAPKs p38alpha, p38beta and p38delta and ERK1/2 are increased in lesional psoriatic skin compared with nonlesional psoriatic skin, and that clearance of psoriasis normalizes the p38 and ERK1/2 activity. Thus, p38 and ERK1/2 might be potential targets in t... |
Do norgestimate and medroxyprogesterone acetate attenuate the atheroprotective effects of 17beta-estradiol in ovariectomized , apolipoprotein E-deficient mice? | [
"To determine whether progestins counteract the cardioprotective effects of estrogen.",
"Controlled animal study.",
"Academic laboratory environment.",
"Female apolipoprotein E-deficient mice.",
"Mice were randomly assigned to groups receiving a sham operation plus placebo pellet, bilateral gonadectomy plus... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adipose Tissue",
"Animals",
"Apolipoproteins E",
"Arteriosclerosis",
"Blood Glucose",
"Body Weight",
"Dose-Response Relationship, Drug",
"Estradiol",
"Female",
"Insulin",
"Lipids",
"Lipoproteins",
"Medroxyprogesterone Acetate",
"Mice",
"Mice, Knockout",
"Norgestrel",
"Organ Size",
... | null | null | null | no | There were no significant differences in lesion area in response to estrogen alone or to estrogen plus the different types and doses of progestins. |
Does blood leucocyte telomere DNA content predict vascular telomere DNA content in humans with and without vascular disease? | [
"Previous studies have suggested that reduced telomere length in circulating leucocytes in humans is associated with premature vascular disease and by implication, accelerated vascular ageing. Importantly, a link between telomere length in circulating leucocytes and the blood vessel wall has never been established.... | [
"OBJECTIVE",
"RESULTS"
] | [
"Aged",
"Aorta, Abdominal",
"Aortic Aneurysm, Abdominal",
"Biopsy",
"Cellular Senescence",
"DNA",
"Female",
"Humans",
"Leukocytes",
"Male",
"Middle Aged",
"Polymerase Chain Reaction",
"Telomere"
] | null | null | null | yes | The findings demonstrate that leucocyte DNA content is predictive of vascular telomere content and is an accurate surrogate for human vascular age. |
Are polymorphisms in the 5 ' region of the CD14 gene associated with eczema in young children? | [
"Variants in the CD14 gene (CD14) are hypothesized to be associated with atopic disorders. However, most studies have only investigated one polymorphism in this gene.",
"We sought to study the association of 5 single nucleotide polymorphisms (SNPs) in the 5' flanking region of CD14 with eczema and serum IgE level... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"5' Flanking Region",
"Child, Preschool",
"Cohort Studies",
"Eczema",
"European Continental Ancestry Group",
"Female",
"Humans",
"Immunoglobulin E",
"Lipopolysaccharide Receptors",
"Male",
"New England",
"Polymorphism, Genetic"
] | null | null | null | yes | Our results contradict previous reports that have found a protective effect of the T allele of SNP rs2569190 (C-159T) against atopic disorders. Nevertheless, these results confirm the importance of polymorphisms in CD14 in the development of atopy, and future studies of this gene region will need to account for linkage... |
Do viral factors correlate with hepatitis B e antigen seroconverson in patients with chronic hepatitis B? | [
"Seroconversion (SC) from hepatitis B envelope antigen (HBeAg) to anti-HBe usually indicates lower viral loads, resolved hepatitis activity and improved long-term outcomes. However, the role of viral factors in the development of SC remains largely unknown. We thus comprehensively studied these factors in 25 patien... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Cohort Studies",
"Female",
"Genotype",
"Hepatitis B Surface Antigens",
"Hepatitis B e Antigens",
"Hepatitis B virus",
"Hepatitis B, Chronic",
"Humans",
"Male",
"Middle Aged",
"Prospective Studies",
"Viral Load"
] | null | null | null | yes | Our findings suggested that viral factors correlate with the development of sustained HBeAg SC or loss. |
Does reduced vital capacity lead to exercise intolerance in patients with ankylosing spondylitis? | [
"It is well-known that pulmonary function is altered in patients with ankylosing spondilitis (AS) owing mainly to the restriction of chest expansion. In addition to musculoskeletal factors, development of pulmonary function abnormalities may also deteriorate exercise tolerance of the patients.",
"The aim of this ... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Case-Control Studies",
"Exercise Test",
"Exercise Tolerance",
"Humans",
"Male",
"Regression Analysis",
"Respiratory Function Tests",
"Spondylitis, Ankylosing",
"Vital Capacity"
] | null | null | null | yes | Rather than musculoskeletal manifestations, exercise intolerance was mainly explained by pulmonary function impairment in AS patients. |
Are methamphetamine and sildenafil ( Viagra ) use linked to unprotected receptive and insertive anal sex , respectively , in a sample of men who have sex with men? | [
"There is evidence that methamphetamine and sildenafil (Viagra) use are associated with sexual risk behaviour among men who have sex with men (MSM). We investigated the association of methamphetamine, sildenafil, and other substance use with unprotected receptive and insertive anal sex among MSM by conducting an en... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Condoms",
"Cross-Sectional Studies",
"Homosexuality, Male",
"Humans",
"Male",
"Methamphetamine",
"Middle Aged",
"Multivariate Analysis",
"Phosphodiesterase Inhibitors",
"Piperazines",
"Prevalence",
"Purines",
"San Francisco",
"Sexual Partners",
"Sild... | null | null | null | yes | Encounter specific associations of methamphetamine and sildenafil use with unprotected receptive and insertive anal sex, respectively, indicate the importance of assessment specificity and tailoring risk reduction efforts to address certain drugs and sexual behavioural roles among MSM. |
Do [ Chorioamnionitis and early-onset neonatal sepsis significantly affect levels of interleukin-6 in very low birth weight neonates ]? | [
"To determine the influence of maternal chorioamnionitis and neonatal sepsis on interleukin-6 (IL-6) levels in cord blood and in blood obtained from very low birth weight (VLBW) infants within the first two hours of life.",
"Prospective clinical study.",
"Institute for the Care of Mother and Child, Prague.",
... | [
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Biomarkers",
"Chorioamnionitis",
"Female",
"Fetal Blood",
"Humans",
"Infant, Newborn",
"Infant, Premature, Diseases",
"Infant, Very Low Birth Weight",
"Interleukin-6",
"Pregnancy",
"Prospective Studies",
"Sepsis"
] | null | null | null | no | IL-6 in cord blood or in neonatal blood within 2 hours of life was not enough sensitive and specific marker of maternal chorioamnionitis as well as for early-onset neonatal sepsis in the group of very low birth weight infants. |
Does [ Research on ginsenosides composition in wild ginseng leave in different growing years ]? | [
"To analyze ginsenosides composition in wild ginseng leaves with different growth years.",
"The analysis was performed on Acquity UPLC BEH Shield RP18 (2.1 mm x 100 mm, 1.7 microm) column, the mobile phase was acetonitrile-0.05% formic acid solution in gradient elution mode. The detection wavelength was at 203 nm... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Drugs, Chinese Herbal",
"Ginsenosides",
"Panax",
"Plant Leaves",
"Time Factors"
] | null | null | null | yes | The established method is simple, accurate and reliable, can be used in ginsenosides determination and fingerprint research of Panax crude drug. The result provides reliable data for the accumulation of ginsenosides and sustainable utilization of ginseng resources. |
Does up-regulation of CNDP2 facilitate the proliferation of colon cancer? | [
"Cytosolic nonspecific dipetidase (CN2) belongs to the family of M20 metallopeptidases. It was stated in previous articles that higher expression levels of CN2 were observed in renal cell carcinoma and breast cancer. Our study explored the correlation between CN2 and colon carcinogenesis.",
"We analysed the relat... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adenocarcinoma",
"Aged",
"Animals",
"Carcinogenesis",
"Cell Line, Tumor",
"Cell Proliferation",
"Colonic Neoplasms",
"Dipeptidases",
"Female",
"Gene Expression Regulation, Neoplastic",
"Humans",
"Male",
"Mice, Nude",
"Middle Aged",
"Transplantation, Heterologous",
"Up-Regulation"
] | null | null | null | yes | Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo. |
Are the two authentic methionine aminopeptidase genes differentially expressed in Bacillus subtilis? | [
"Two putative methionine aminopeptidase genes, map (essential) and yflG (non-essential), were identified in the genome sequence of Bacillus subtilis. We investigated whether they can function as methionine aminopeptidases and further explored possible reasons for their essentiality or dispensability in B. subtilis.... | [
"BACKGROUND",
"RESULTS"
] | [
"Aminopeptidases",
"Bacillus subtilis",
"Escherichia coli",
"Evolution, Molecular",
"Gene Deletion",
"Gene Expression Regulation, Bacterial",
"Gene Expression Regulation, Enzymologic",
"Genome, Bacterial",
"Methionyl Aminopeptidases",
"Plasmids",
"RNA, Bacterial",
"RNA, Ribosomal, 16S",
"Res... | null | null | null | yes | Both MAP_Bs and YflG_Bs are functional methionine aminopeptidases in vitro and in vivo. The high expression level of map and low expression level of yflG may account for their essentiality and dispensality in B. subtilis, respectively, when cells are grown under laboratory conditions. Their difference in activity on sy... |
Does heat stress limit infarct size in the isolated perfused rabbit heart? | [
"Heat stress, with the expression of heat stress proteins, has been shown to protect the rabbit heart in vitro against global ischaemia/reperfusion injury, though no benefit is apparent in an in vivo rabbit model of infarct size. The aim of this study was therefore to investigate this discrepancy and to discover wh... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Animals",
"Blood Pressure",
"Heart Rate",
"Heat-Shock Proteins",
"Hot Temperature",
"Male",
"Myocardial Infarction",
"Myocardium",
"Rabbits"
] | null | null | null | yes | Heat stress limits infarct size in this rabbit model. However it appears to have additional adverse effects, probably on the blood, which may override any benefit associated with myocardial stress protein synthesis. |
Is regional control preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer? | [
"To analyze a cohort of patients with HPV positive, oropharyngeal squamous cell carcinoma (OPSCC) treated with lower radiation dose to clinically involved lymph nodes.",
"We retrospectively identified patients with HPV positive, OPSCC treated with definitive chemoradiotherapy (70-74.4Gy) to the primary site and, ... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Carcinoma, Squamous Cell",
"Combined Modality Therapy",
"Disease-Free Survival",
"Female",
"Humans",
"Lymph Nodes",
"Male",
"Middle Aged",
"Neoplasm Recurrence, Local",
"Oropharyngeal Neoplasms",
"Papillomavirus Infections",
"Radiotherapy Dosage",
"Radiotherapy, Conform... | null | null | null | yes | In this exploratory analysis, regional lymph node control in HPV positive oropharyngeal cancer was not compromised by dose de-escalated radiotherapy to involved nodes in the setting of concurrent cisplatin based chemotherapy. |
Is paraoxonase-1 associated with oxidative stress , fibrosis and FAS expression in chronic liver diseases? | [
"We previously reported that paraoxonase-1 activity measurement may be useful for the evaluation of liver diseases. Because oxidative stress plays a role in liver apoptosis, and lipid peroxides are hydrolyzed by paraoxonase-1, we have extended our studies to explore the relationships between this enzyme and oxidati... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Apoptosis",
"Aryldialkylphosphatase",
"Biopsy",
"Chronic Disease",
"Female",
"Humans",
"Liver Cirrhosis",
"Liver Diseases",
"Liver Function Tests",
"Male",
"Middle Aged",
"Oxidative Stress",
"Reproducibility of Results",
"fas Receptor"
] | null | null | null | yes | These results suggest an active role of PON1 in the regulation of oxidative stress, fibrosis and hepatic cell apoptosis in chronic liver diseases. |
Does dynamic Contrast-Enhanced Magnetic Resonance Imaging suggest Normal Perfusion in Normal-Appearing White Matter in Multiple Sclerosis? | [
"Multiple sclerosis (MS) is a chronic, inflammatory disease of the central nervous system and has been associated with reduced perfusion in normal-appearing white matter (NAWM). The magnitude of this hypoperfusion is unclear. The present study aims to quantify NAWM perfusion with dynamic contrast-enhanced (DCE) mag... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Cerebrovascular Circulation",
"Contrast Media",
"Female",
"Humans",
"Image Enhancement",
"Magnetic Resonance Imaging",
"Male",
"Middle Aged",
"Monte Carlo Method",
"Multiple Sclerosis, Relapsing-Remitting",
"White Matter",
"Young Adult"
] | null | null | null | yes | Despite high statistical power, we could not confirm previous reports of NAWM hypoperfusion in MS. This indicates that, at least in our patient cohort, potential hypoperfusion is much less pronounced than reported in previous studies. |
Does hepatic gene expression profiling reveal protective responses in Atlantic salmon vaccinated against furunculosis? | [
"Furunculosis, a disease caused with gram negative bacteria Aeromonas salmonicida produces heavy losses in aquaculture. Vaccination against furunculosis reduces mortality of Atlantic salmon but fails to eradicate infection. Factors that determine high individual variation of vaccination efficiency remain unknown. W... | [
"BACKGROUND",
"RESULTS"
] | [
"Aeromonas salmonicida",
"Amino Acid Sequence",
"Animals",
"Anti-Bacterial Agents",
"Complement System Proteins",
"Female",
"Furunculosis",
"Gene Expression Profiling",
"Gene Expression Regulation",
"Iron",
"Liver",
"Male",
"Molecular Sequence Data",
"Oligonucleotide Array Sequence Analysi... | null | null | null | yes | Efficiency of vaccination against furunculosis depends largely on the ability of host to neutralize the negative impacts of immune responses combined with efficient clearance and prevention of tissue damages. |
Is the functional HERG variant 897T associated with Conn 's adenoma? | [
"Aldosterone secreting adenomas (aldosteronomas) have an unknown molecular origin. Ion channel currents are involved in signal transduction leading to aldosterone synthesis and secretion. HERG (human-ether-a-go-go-related gene) encodes for a potassium channel responsible for the outward rectifying delayed current a... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adrenocortical Adenoma",
"Adult",
"Aged",
"Case-Control Studies",
"Electrocardiography",
"Ether-A-Go-Go Potassium Channels",
"Female",
"Gene Expression",
"Gene Frequency",
"Humans",
"Hyperaldosteronism",
"Hypertension",
"Male",
"Middle Aged",
"Mutation",
"Sequence Analysis, DNA"
] | null | null | null | yes | The common functional HERG variant 897T may predispose to the development of aldosteronoma. |
Is 25-Hydroxyvitamin D closely related with the function of the pancreatic islet β cells? | [
"This study is to investigate the relationship between 25-Hydroxyvitamin D (25-OH-D) and pancreatic islet β cell function under different glucose tolerance statuses in China.",
"Totally, 180 patients with type 2 diabetes mellitus (DM group), 178 patients with impaired fasting glucose/impaired glucose tolerance (I... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [] | null | null | null | yes | Our results suggest that 25-OH-D is closely related with the function of the pancreatic islet β cells and is one of the influential factors of pancreatic islet β cell function. |
Is the Mini-Mental State Exam ( MMSE ) sensitive to cognitive impairment in bariatric surgery candidates? | [
"Cognitive dysfunction is common among bariatric surgery candidates and associated with poorer weight loss outcomes. Identification of a brief screening measure to detect cognitive impairment in this population is needed, because comprehensive neuropsychological evaluations may not be available in all clinical sett... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Bariatric Surgery",
"Cognition",
"Cognition Disorders",
"Female",
"Humans",
"Male",
"Mental Status Schedule",
"Middle Aged",
"Neuropsychological Tests",
"Obesity, Morbid",
"ROC Curve",
"Reproducibility of Results",
"Surveys and Questionnaires",
"Young Adult"
] | null | null | null | no | These findings suggest that the MMSE is a poor screener for cognitive impairment in bariatric surgery candidates. Future research is needed to identify or develop cognitive screeners for use in this population. |
Does a standardized kudzu extract ( NPI-031 ) reduce alcohol consumption in nontreatment-seeking male heavy drinkers? | [
"We previously demonstrated that short-term treatment with a standardized kudzu extract (NPI-031) reduced alcohol drinking by men and women in a natural setting. The present study was conducted in nontreatment-seeking heavy drinkers to assess the safety and efficacy of 4 weeks of kudzu extract in an outpatient sett... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Alcohol Deterrents",
"Alcohol Drinking",
"Alcoholism",
"Double-Blind Method",
"Drug-Seeking Behavior",
"Ethanol",
"Humans",
"Male",
"Medication Adherence",
"Plant Extracts",
"Pueraria",
"Young Adult"
] | null | null | null | yes | A standardized formulation of kudzu extract produced minimal side effects, was well-tolerated, and resulted in a modest reduction in alcohol consumption in young nontreatment-seeking heavy drinkers. Additional studies using treatment-seeking alcohol-dependent persons will be necessary to determine the usefulness of thi... |
Does exercise training improve the soleus muscle morphology in experimental diabetic nerve regeneration? | [
"In this study we evaluate the effects of exercise training (10 weeks) on soleus muscle morphology in diabetic nerve regeneration after injury by sciatic nerve crush.",
"Wistar rats were assigned to either a non-diabetic (n = 6), non-diabetic injured (n = 6), diabetic (n = 6), diabetic injured (DC; n = 9), or tra... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Analysis of Variance",
"Animals",
"Blood Vessels",
"Body Weight",
"Diabetic Neuropathies",
"Disease Models, Animal",
"Exercise Test",
"Fasting",
"Glycemic Index",
"Male",
"Microscopy, Electron, Transmission",
"Muscle, Skeletal",
"Nerve Crush",
"Nerve Regeneration",
"Physical Conditionin... | null | null | null | yes | Sciatic nerve injury was found to promote soleus muscle atrophy and ultrastructural alterations in experimental diabetic nerve regeneration, which were partially reversed by exercise training. |
Does pretreatment serum anti-müllerian hormone predict long-term ovarian function and bone mass after chemotherapy for early breast cancer? | [
"Administration of chemotherapy to premenopausal women shortens their reproductive lifespan by depleting nonrenewable oocytes. Preservation of fertility is a priority for many such women, and identification of women at risk of infertility is therefore important. However, age is the only patient characteristic curre... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aging",
"Amenorrhea",
"Anti-Mullerian Hormone",
"Antineoplastic Agents",
"Bone Density",
"Bone and Bones",
"Breast Neoplasms",
"Female",
"Fertility",
"Follicle Stimulating Hormone",
"Gonadal Steroid Hormones",
"Humans",
"Infertility",
"Likelihood Functions",
"Logistic Models"... | null | null | null | yes | Measurement of AMH at cancer diagnosis predicts long-term ovarian function after chemotherapy. Use of this in clinical practice may allow better prediction of chemotherapy-related risk to future fertility. |
Does a single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influence human male fertility? | [
"The development of novel fertilization treatments, including in vitro fertilization and intracytoplasmic injection, has made pregnancy possible regardless of the level of activity of the spermatozoa; however, the etiology of male-factor infertility is poorly understood. Multiple studies, primarily through the use ... | [
"BACKGROUND",
"RESULTS"
] | [
"Acrosome",
"Female",
"Fertility",
"Gene Expression Regulation",
"Genes, X-Linked",
"Genetic Diseases, X-Linked",
"Humans",
"Infertility, Male",
"Male",
"Meiosis",
"Organ Specificity",
"Phosphoglycerate Mutase",
"Polymorphism, Single Nucleotide",
"Pregnancy",
"Sperm Tail",
"Spermatids"... | null | null | null | yes | These results suggest that PGAM4, an X-linked retrogene, is a fundamental gene in human male reproduction and may escape meiotic sex chromosome inactivation. These findings provide fresh insight into elucidating the mechanisms of male infertility. |
Is antenatal indomethacin tocolysis associated with an increased need for surgical ligation of patent ductus arteriosus in preterm infants? | [
"To examine the effect of antenatal indomethacin (AI) exposure on the incidence, response to postnatal indomethacin (PI), and need for surgical ligation of patent ductus arteriosus (PDA) in preterm infants.",
"We performed a retrospective matched cohort study of infants born at < or = 30 weeks' gestation after ex... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adult",
"Case-Control Studies",
"Cohort Studies",
"Ductus Arteriosus, Patent",
"Female",
"Humans",
"Indomethacin",
"Infant, Newborn",
"Infant, Premature",
"Ligation",
"Male",
"Premature Birth",
"Retrospective Studies",
"Tocolytic Agents"
] | null | null | null | yes | In infants born preterm (< or = 30 weeks) with a PDA, antenatal exposure to indomethacin was associated with an increased rate of therapeutic failure of PI and an increased rate of surgical PDA ligation compared with controls without such antenatal exposure. |
Does a Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs allow Prediction of Human Brain Target Site Concentrations? | [
"Predicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous system. We propose a generic mathematical model to describe the pharmacokinetics in brain compartments, and apply this model to predict human brain disposition.",
"A m... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Acetaminophen",
"Animals",
"Blood-Brain Barrier",
"Brain",
"Humans",
"Male",
"Models, Biological",
"Models, Theoretical",
"Morphine",
"Rats",
"Rats, Wistar",
"Tissue Distribution"
] | null | null | null | yes | A multi-compartmental brain pharmacokinetic model was developed and its structure could adequately describe data across nine different drugs. The model could be successfully translated to predict human brain concentrations. |
Are children with Down syndrome high-risk for severe respiratory syncytial virus disease? | [
"To assess Down syndrome as an independent risk factor for respiratory syncytial virus (RSV) hospitalization in children younger than 3 years of age and to evaluate illness severity.",
"A retrospective cohort study of children enrolled in the military health system database was conducted. The effect of Down syndr... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Child",
"Child, Preschool",
"Down Syndrome",
"Female",
"Follow-Up Studies",
"Gestational Age",
"Hospitalization",
"Humans",
"Incidence",
"Infant",
"Infant, Newborn",
"Infant, Premature",
"Male",
"Prevalence",
"Respiratory Syncytial Virus Infections",
"Retrospective Stu... | null | null | null | yes | Down syndrome is independently associated with an increased risk for RSV hospitalization. Children with Down syndrome are older at time of RSV hospitalization and have more severe RSV illness than children without Down syndrome. This increased risk for hospitalization continues beyond 24 months. |
Are biliary carcinoembryonic antigen levels a marker for cholangiocarcinoma? | [
"Cholangiocarcinoma develops in 5% to 15% of patients with choledochal cysts, sclerosing cholangitis, and intrahepatic stones. The detection of cholangiocarcinoma in patients with premalignant biliary conditions has been difficult. Serum levels of carcinoembryonic antigen (CEA) have been neither sensitive nor speci... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Bile",
"Bile Duct Neoplasms",
"Bile Ducts, Intrahepatic",
"Carcinoembryonic Antigen",
"Cholangiocarcinoma",
"Cholangitis, Sclerosing",
"Choledochal Cyst",
"Cholelithiasis",
"Cholestasis",
"Diagnosis, Differential",
"Humans",
"Middle Aged"
] | null | null | null | yes | Increased levels of CEA can be detected in the bile of patients with chlolangiocarcinoma. Monitoring these levels may have a role in the management of cholangiocarcinoma as well as premalignant biliary conditions such as choledochal cysts and sclerosing cholangitis. |
Do `` Maybe they have found something new '' participants ' views on returning cohort psychosocial survey results? | [
"Although greater attention is currently being paid to participants in research, no studies have dealt so far with the issue of returning aggregate psychosocial results to cohort participants.",
"(i) To explore participants' views about disclosure of the aggregate results of a French national psychosocial cohort ... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"METHODS",
"RESULTS"
] | [
"Adult",
"Aged",
"Breast Neoplasms",
"Disclosure",
"Female",
"Genes, BRCA1",
"Genes, BRCA2",
"Genetic Predisposition to Disease",
"Genetic Testing",
"Grounded Theory",
"Humans",
"Interviews as Topic",
"Longitudinal Studies",
"Middle Aged",
"Mutation",
"Qualitative Research",
"Risk As... | null | null | null | yes | Investigators should ascertain participants' expectations and preferences by consulting them before disclosing the results obtained. Although the disclosure process may not meet participants' expectations completely, consultation is the key to preventing them from having irrealistic expectations about the information t... |
Is mucinous histology a risk factor for nodal metastases in endometrial cancer? | [
"Mucinous adenocarcinoma of the endometrium (MUC) is a rare histological variant of endometrial carcinoma accounting for 1-9% of endometrioid tumors. Few studies have characterized its clinical behavior. This is a case-control study at a single institution comparing the risk factors and clinical course of MUC relat... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adenocarcinoma, Mucinous",
"Adult",
"Aged",
"Aged, 80 and over",
"Case-Control Studies",
"Endometrial Neoplasms",
"Female",
"Humans",
"Lymph Nodes",
"Lymphatic Metastasis",
"Middle Aged",
"Prognosis",
"Risk Factors",
"Survival Rate"
] | null | null | null | yes | Mucinous differentiation was found to be an independent predictor of lymph node metastasis in the study population. Comprehensive surgical staging including retroperitoneal node dissection should be strongly considered in all endometrial cancer patients with predominantly mucinous histology. |
Does peptide deformylase inhibitor actinonin reduce celastrol 's HSP70 induction while synergizing proliferation inhibition in tumor cells? | [
"Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastrol's anti-tumor effects through HSP70 interference has been reported, but because siRNA technology is diffi... | [
"BACKGROUND",
"METHODS",
"RESULTS"
] | [
"Amidohydrolases",
"Antineoplastic Agents",
"Cell Line, Tumor",
"Cell Nucleus",
"Cell Proliferation",
"DNA-Binding Proteins",
"Drug Synergism",
"Gene Expression Regulation, Neoplastic",
"HSP70 Heat-Shock Proteins",
"Heat Shock Transcription Factors",
"Heat-Shock Proteins",
"Humans",
"Hydroxa... | null | null | null | yes | Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action. |
Is co-morbid cardiovascular disease and depression : sequence of disease onset linked to mental but not physical self-rated health . Results from a cross-sectional , population-based study? | [
"Self-rated health has been linked to important health and survival outcomes in individuals with co-morbid depression and cardiovascular disease (CVD). It is not clear how the timing of depression onset relative to CVD onset affects this relationship. We aimed to first identify the prevalence of major depressive di... | [
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Adolescent",
"Adult",
"Aged",
"Aged, 80 and over",
"Australia",
"Cardiovascular Diseases",
"Comorbidity",
"Cross-Sectional Studies",
"Depression",
"Diagnostic Self Evaluation",
"Female",
"Humans",
"Logistic Models",
"Male",
"Middle Aged",
"Young Adult"
] | null | null | null | yes | MDD is most common prior to the onset of CVD. Further, there is an association between pre-morbid MDD and poorer self-rated mental health. To our knowledge, this is the first time this has been demonstrated in a national, population-based survey. As self-rated health has been shown to predict important outcomes such as... |
Do eBER2 RNA-induced transcriptome changes identify cellular processes likely targeted during Epstein Barr Virus infection? | [
"Little is known about the physiological role of the EBER1 and 2 nuclear RNAs during Epstein Barr viral infection. The EBERs are transcribed by cellular RNA Polymerase III and their strong expression results in 106 to 107 copies per EBV infected cell, making them reliable diagnostic markers for the presence of EBV.... | [
"BACKGROUND",
"RESULTS"
] | [] | null | null | null | yes | These results provide new avenues to the understanding of EBER2 and EBV biology, and set the grounds for a more in depth functional analysis of EBER2 using transcriptome activity measurements. |
Is pulmonary hypertension in patients with advanced heart failure associated with increased levels of interleukin-6? | [
"Inflammatory, endothelial and neurohormonal biomarkers are involved in heart failure (HF) and pulmonary hypertension (PH) pathogenesis.",
"To study these biomarkers in PH due to advanced HF.",
"Thirty adults with HF were included. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reacti... | [
"BACKGROUND",
"OBJECTIVE",
"METHODS",
"RESULTS"
] | [
"Aged",
"Biomarkers",
"C-Reactive Protein",
"Endothelin-1",
"Female",
"Heart Failure",
"Hemodynamics",
"Humans",
"Hypertension, Pulmonary",
"Interleukin-6",
"Linear Models",
"Male",
"Middle Aged",
"Multivariate Analysis",
"Natriuretic Peptide, Brain",
"Peptide Fragments",
"Pulmonary ... | null | null | null | yes | Inflammatory biomarkers correlate to PH severity. IL-6 predicts sPAP in advanced HF. |
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