title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Nature of water transport and electro-osmosis in nafion: insights from first-principles molecular dynamics simulations under an electric field. | The effects of water content on water transport and electro-osmosis in a representative polymer electrolyte membrane, Nafion, are investigated in detail by means of first-principles molecular dynamics (MD) simulations in the presence of a homogeneous electric field. We have directly evaluated electro-osmotic drag coeff... | 18,717,541 |
Estimation of the persistence length of DNA from the torsion elastic constant and supercoiling free energy: effect of ethylene glycol. | Two different methods are proposed to estimate the persistence length ( P) of DNA from the measured torsion elastic constant (alpha) and the twist energy parameter ( E T ) that governs the supercoiling free energy. The first method involves Monte Carlo simulations and reversible-work calculations of E T for model DNAs ... | 18,717,543 |
Conjugating luminescent CdTe quantum dots with biomolecules. | Newly prepared CdTe quantum dots ( QD) bearing shells of water solubility providing capping agents (i.e., thioglycolic acid ( TGA) and 2-(dimethylamino)ethanethiol hydrochloride (DMAET) were subjected to electrostatic assays with several proteins (i.e., cytochrome c (cyt c) and human serum albumin (HSA). In particular,... | 18,717,546 |
Observation of singlet cycloreversion of thymine oxetanes by direct photolysis. | An ultrafast broadband transient absorption spectroscopic study of the direct photolysis of oxetane DMT-BP [which is the oxetane adduct of 1,3-dimethylthymine (DMT) with benzophenone (BP)] is presented. Previous nanosecond time-resolved absorption studies by other researchers observed that direct photolysis of such oxe... | 18,717,552 |
Thermodynamics of micellization of beta-sheet forming poly(acrylic acid)-block-poly(l-valine) hybrids. | The phase behavior and thermodynamic of micellization of three hybrid poly(acrylic acid)- block-poly( l-valine), namely PAA 40-b-PLVAL 100, PAA 80-b-PLVAL 100, and PAA 80-b-PLVAL 80, were investigated. beta-sheet formation in these polymeric systems resulted in a dominant enthalpic micellization process that exhibited ... | 18,717,556 |
The mechanism of long-range exciton diffusion in a nematically organized porphyrin layer. | The exciton diffusion length in a nematically organized meso-tetra(4-n-butylphenyl)porphyrin (TnBuPP) layer was found to exceed 40 nm at a temperature of 90 K and to be equal to 22 +/- 3 nm at 300 K. The exciton diffusion coefficient decreases from > or = 3.1 x 10(-6) m(2)/s at 90 K to (2.5 +/- 0.5) x 10(-7) m(2)/s ... | 18,717,557 |
Ternary inverse opal system for convenient and reversible photonic bandgap tuning. | A ternary system, consisting of air, an air-core/dense-silica-shell core-shell particle, and liquids has been used to fabricate an inverse opal structure with low fill factor, high refractive index contrast, and reversible tuning capabilities of the bandgap spectral position. The original close-packed opal structure is... | 18,717,578 |
Biomimetic synthesis and structural revision of (+/-)-tridachiahydropyrone. | A short synthesis of the revised structure of the marine natural product tridachiahydropyrone is described. A novel biomimetic photochemical electrocyclization was employed to construct the bicyclic carbon framework from an open-chain polyene precursor. The spectroscopic data matched that of the isolated natural produc... | 18,717,585 |
Assembly and disassembly of the photosystem II manganese cluster reversibly alters the coupling of the reaction center with the light-harvesting phycobilisome. | The light-driven oxidative assembly of Mn (2+) ions into the H 2O oxidation complex (WOC) of the photosystem II (PSII) reaction center is termed photoactivation. The fluorescence yield characteristics of Synechocystis sp. PCC6803 cells undergoing photoactivation showed that basal fluorescence, F 0, exhibited a characte... | 18,717,592 |
Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein. | We have designed and synthesized a cyclic, bivalent Smac mimetic (compound 3) and characterized its interaction with the X-linked inhibitor of apoptosis protein (XIAP). Compound 3 binds to XIAP containing both BIR2 and BIR3 domains with a biphasic dose-response curve representing two binding sites with IC 50 values of ... | 18,717,598 |
Adjuvant high-dose intravenous immunoglobulin therapy can be easily and safely introduced as an alternative treatment in patients with severe pemphigus vulgaris: a retrospective preliminary study. | Long-term corticosteroid therapy, often in association with other immunosuppressive agents, is considered the mainstay of pemphigus vulgaris (PV) therapy. Recent evidence has been changing this paradigm as patients who are non-responsive to conventional therapies or who experience severe adverse effects have been succe... | 18,717,608 |
Whole sediment toxicity identification evaluation tools for pyrethroid insecticides: III. Temperature manipulation. | Since the toxicity of pyrethroid insecticides is known to increase at low temperatures, the use of temperature manipulation was explored as a whole-sediment toxicity identification evaluation (TIE) tool to help identify sediment samples in which pyrethroid insecticides are responsible for observed toxicity. The amphipo... | 18,717,618 |
Evaluation of estrogenic activity of parabens and their chlorinated derivatives by using the yeast two-hybrid assay and the enzyme-linked immunosorbent assay. | We assessed the estrogen agonist activities of 21 parabens and their chlorinated derivatives by using yeast two-hybrid assays incorporating either the human or medaka (Oryzias latipes) estrogen receptor alpha (hERalpha and medERalpha, respectively), and by using hERalpha competitive enzyme-linked immunosorbent assay (E... | 18,717,622 |
Antibiotics as a chemical stressor affecting an aquatic decomposer-detritivore system. | Recent evidence indicates that a variety of antibiotic residues may affect the integrity of streams located downstream from wastewater treatment plants. Aquatic communities comprising bacterial and fungal decomposers and invertebrate detritivores (shredders) play an important role in the decomposition of allochthonous ... | 18,717,623 |
Oxidative stress and DNA damage in broad bean (Vicia faba L.) seedlings induced by thallium. | Thallium (Tl) is a metal of great toxicological concern because it is highly toxic to all living organisms through mechanisms that are yet poorly understood. Since Tl is accumulated by important crops, the present study aimed to analyze the biological effects induced by bioaccumulation of Tl in broad bean (Vicia faba L... | 18,717,625 |
Gene expression profiling-based in silico approach to identify potential vaccine candidates and drug targets against B. pertussis and B. parapertussis. | Whooping cough (pertussis) caused by B. pertussis (B.p) is still serious public health threat. B. parapertussis (B.pp), closely related to B.p, also causes whooping cough. The incidence of B.pp infections has been increasing over the last decades, partly because pertussis vaccines have low efficiency against B.pp infec... | 18,717,643 |
Regulation of gene expression in the nervous system. | The nervous system contains a multitude of cell types which are specified during development by cascades of transcription factors acting combinatorially. Some of these transcription factors are only active during development, whereas others continue to function in the mature nervous system to maintain appropriate gene-... | 18,717,648 |
The role of IL-12 and TNF-alpha in AIDP and AMAN. | Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN) have been described as two major subtypes of Guillain-Barré syndrome (GBS); however, the possible difference of their immune-inflammatory pathogenesis remains unclear. In this study, by using FACS and enzyme-linked i... | 18,717,726 |
Host-parasite coevolution and patterns of adaptation across time and space. | The description of coevolutionary dynamics requires a characterization of the evolutionary dynamics of both the parasite and its host. However, a thorough description of the underlying genetics of the coevolutionary process is often extremely difficult to carry out. We propose that measures of adaptation (mean populati... | 18,717,749 |
Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis. | Melibiose/rhamnose permeability test is used for noninvasive intestinal mucosa barrier testing. However, the possible escape route of the absorbed saccharides through either intact or impaired blood-biliary barriers has not so far been explored. The objective of the present study was therefore two-fold: First, to descr... | 18,717,760 |
Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains. | We investigated the dietary and gender influences on the expression and functionality of cholangiocyte bile salt transporters and development of biliary hyperplasia in cholesterol gallstone-susceptible C57L/J and resistant AKR/J mice. C57L and AKR mice were fed chow, a lithogenic diet, or a cholic acid-containing diet ... | 18,717,763 |
An undergraduate paediatric curriculum based on clinical presentations and 'key features'. | We wanted to develop and define an undergraduate paediatric curriculum in a way that would facilitate the development of clinical reasoning. We sent a series of four questionnaires to paediatricians in New Zealand to explore their perceptions of common presenting complaints for an undergraduate paediatrics curriculum. ... | 18,717,768 |
Structural basis of specific TraD-TraM recognition during F plasmid-mediated bacterial conjugation. | F plasmid-mediated bacterial conjugation requires interactions between a relaxosome component, TraM, and the coupling protein TraD, a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore. Here we present the crystal structure of the C-terminal tail of TraD bound to the TraM tetramerization doma... | 18,717,787 |
Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells. | Neuroblastoma cells are capable of hypoxic adaptation, but the mechanisms involved are not fully understood. We hypothesized that caveolin-1 (cav-1), a plasma membrane signal molecule, might play a role in protecting neuroblastoma cells from oxidative injury by modulating nitric oxide (NO) production. We investigated t... | 18,717,816 |
Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D(1) receptor signaling in rat nucleus accumbens and dorsal striatum. | Nociceptin/orphanin FQ (N/OFQ) has been reported to inhibit dopamine (DA) release in basal ganglia mainly by acting on NOP receptors in substantia nigra and ventral tegmental area. We investigated whether N/OFQ could affect DA transmission by acting at either DA nerve endings or DA-targeted post-synaptic neurons. In sy... | 18,717,817 |
Intergenerational transmission of social anxiety: the role of social referencing processes in infancy. | Responses to an unfamiliar adult were examined in infants of mothers with social phobia (N= 79) and infants of nonanxious comparison mothers (N= 77) at 10 and 14 months in a social referencing paradigm. On each occasion, a female stranger first interacted with the mother and then approached and interacted with the infa... | 18,717,906 |
The effects of background television on the toy play behavior of very young children. | This experiment tests the hypothesis that background, adult television is a disruptive influence on very young children's behavior. Fifty 12-, 24-, and 36-month-olds played with a variety of toys for 1 hr. For half of the hour, a game show played in the background on a monaural TV set. During the other half hour, the T... | 18,717,911 |
Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. | UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage. It alters immune function, pigmentation and it is certainly responsible for a large part of photoaging changes. Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to pro... | 18,717,957 |
Glucose control in the UKPDS: what did we learn? | The UK Prospective Diabetes Study (UKPDS) set out to establish whether improved glucose control could alleviate the macrovascular and microvascular complications of diabetes and to compare the relative merits of diet, oral glucose-lowering agents or insulin in achieving this objective. The study broke many of the rules... | 18,717,972 |
UKPDS-modelling of cardiovascular risk assessment and lifetime simulation of outcomes. | Although known principally as a clinical trial, the UK Prospective Diabetes Study (UKPDS) provided longitudinal data which helped define the natural history of cardiovascular complications in Type 2 diabetes. Using clinical, epidemiological, statistical and economics methods, UKPDS investigators developed mathematical ... | 18,717,978 |
The UKPDS and its global impact. | Aim To review the world-wide impact of the United Kingdom Prospective Diabetes Study (UKPDS) on diabetes health care since publication of the main study results in 1998. Methods The major papers published by the UKPDS were reviewed, e-mails and faxes were sent to diabetes associations in various regions of the world se... | 18,717,981 |
Rabies trend in China (1990-2007) and post-exposure prophylaxis in the Guangdong province. | Rabies is a major public-health problem in developing countries such as China. Although the recent re-emergence of human rabies in China was noted in several epidemiological studies, little attention was paid to the reasons behind this phenomenon paralleling the findings of the previous reports. The purpose of this stu... | 18,717,989 |
Disseminated peritoneal hydatidosis following blunt abdominal trauma: A case report. | A middle age lady presented with abdominal pain was diagnosed to have multiple peritoneal and hepatic hydatid cysts on CT scan. Retrospectively she was found to have suffered blunt abdominal trauma. | 18,718,001 |
Misoprostol in addition to routine treatment of postpartum hemorrhage: a hospital-based randomized-controlled trial in Karachi, Pakistan. | Postpartum hemorrhage (PPH) remains a major killer of women worldwide. Standard uterotonic treatments used to control postpartum bleeding do not always work and are not always available. Misoprostol's potential as a treatment option for PPH is increasingly known, but its use remains ad hoc and available evidence does n... | 18,718,007 |
Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity. | Malignant melanomas are characterized by increased karyotypic complexity, extended aneuploidy and heteroploidy. We report a melanoma metastasis to the peritoneal cavity with an exceptionally stable, abnormal pseudodiploid karyotype as verified by G-Banding, subtelomeric, centromeric and quantitative Fluorescence in Si... | 18,718,029 |
The roles of bronchodilators, supplemental oxygen, and ventilatory assistance in the pulmonary rehabilitation of patients with chronic obstructive pulmonary disease. | In patients with chronic obstructive pulmonary disease, pulmonary rehabilitation significantly improves dyspnea, exercise capacity, quality of life, and health-resource utilization. These benefits result from a combination of education (especially in the promotion of collaborative self-management strategies and physica... | 18,718,038 |
Reduced growth and integrin expression of prostate cells cultured with lycopene, vitamin E and fish oil in vitro. | Integrins are transmembrane proteins that facilitate the interaction of cells with the extracellular environment. They have also been implicated in cancer progression. The effects of nutrients thought to be involved in the prevention of prostate cancer on integrin expression have not been determined. Prostate cancer ce... | 18,718,045 |
[Expression of a tumor related gene chp2 in leukemia cells]. | The purpose of this study was to investigate the expression feature of a human tumor related gene chp2 in leukemia primary cells and leukemia cell lines, real-time quantitative PCR (RQ-PCR) was performed to detect the expression level of chp2 gene in peripheral blood mononuclear cells from 10 healthy individuals (as co... | 18,718,049 |
[DNA content and cell cycle analysis of myeloma cells in patients with multiple myeloma]. | The study was aimed to investigate the genetic background and proliferation characteristics of multiple myeloma (MM). Myeloma cells were isolated from bone marrow of 19 MM patients by direct immunomagnetic cell sorting and the DNA content and cell cycle analysis were carried out by flow cytometry. The results showed th... | 18,718,069 |
[Hemostatic effect of hemocoagulase agkistrodon and its mechanism]. | This study was aimed to investigate the hemostatic effects of hemocoagulase agkistrodon (HCA) and its mechanism. The procoagulative and hemostatic effects of HCA were evaluated by using rabbit blood coagulatin time and mouse tail bleeding time; the mechanisms of HCA hemostatic effect were analyzed by using rabbit blood... | 18,718,083 |
Pharmacokinetics of tramadol in rat plasma and cerebrospinal fluid after intranasal administration. | We have evaluated the potential of intranasal administration of tramadol. The pharmacokinetic behaviour of tramadol in rat plasma and cerebrospinal fluid (CSF) after intranasal administration was determined and compared with those after intravenous and oral administration. Serial plasma and CSF samples were collected f... | 18,718,117 |
Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts. | Important targets for the prevention and treatment of diabetic complications include aldose reductase (AR) inhibitors (ARIs) and inhibitors of advanced glycation endproduct (AGE) formation. Here we evaluate the inhibitory activities of prenylated flavonoids isolated from Sophora flavescens, a traditional herbal medicin... | 18,718,128 |
Development of a size exclusion chromatography-electrochemical detection method for the analysis of total organic and inorganic chloramines. | A size exclusion chromatography (SEC) followed by post-column reaction with iodide and electrochemical detection method is developed for analysis of total organic and inorganic chloramines. Ammonium chloride and a group of test compounds (Glycine, Tyrosine, DL-Alanyl-DL-Alanine, Arg-Gly-Asp-Ser, Bradykinin, Aprotinin, ... | 18,718,133 |
Validation and application of an HPLC method for determination of di (2-ethylhexyl) phthalate and mono (2-ethylhexyl) phthalate in liver samples. | A reversed-phase gradient elution, UV detection method is developed for the simultaneous determination of mono (2-ethylhexyl) phthalate [MEHP] and di (2-ethylhexyl) phthalate [DEHP] in tissue samples. The method is validated with respect to extraction recovery, inter and intra-day precision, linearity of response, dete... | 18,718,139 |
Determination of residual isobutylene oxide--a genotoxic starting material in a drug substance by static headspace gas chromatography. | A sensitive static headspace gas chromatography (sHS-GC) method is developed and validated for the determination of residual isobutylene oxide (IBO)-a genotoxic starting material in a drug substance for Phase I clinical trial studies. The experimental parameters, such as headspace vial pressure, headspace oven temperat... | 18,718,141 |
Special intervention zones. | The Special Intervention Zones (SIZ) of the former Onchocerciasis Control Programme (OCP) were launched in December 2002, following the closure of the OCP, to sustain the momentum that had been gained for onchocerciasis control through Mectizan distribution and vector control. The donation of Mectizan in 1987 was fortu... | 18,718,150 |
Networks of primary and secondary care services: how to organise services so as to promote efficiency and quality in access while reducing costs. | Governments in countries with national health systems have been concerned with how to organise services so as to achieve improvements in efficiency and quality in healthcare delivery, as well as to control costs. In this study, a stochastic discrete event simulation model to study the organisation of primary and second... | 18,718,161 |
Valproic acid-mediated transcriptional regulation of human GM3 synthase (hST3Gal V) in SK-N-BE(2)-C human neuroblastoma cells. | To investigate whether valproic acid (VPA) modulates human GM3 synthase (hST3Gal V) mRNA expression, as a part of ganglioside GM3 biosynthesis, in human neuroblastoma cells. Using RT-PCR and immunofluorescent confocal microscopy, we examined hST3Gal V mRNA and GM3 levels during VPA-induced differentiation of human neur... | 18,718,167 |
Osteogenic-related gene expression profiles of human dental follicle cells induced by dexamethasone. | Human dental follicle cells (hDFC) have the ability to differentiate into mineralized tissue-forming cells during root and periodontal development or osteogenic induction in vitro. The present study aimed to validate the osteogenic induction of hDFC by dexamethasone (DEX) and to explore the changes of related genes res... | 18,718,169 |
Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. | Medical application of Panax ginseng was first found in "Shen-Nong Herbal Classic"around 200 AD Panax quinquefolium was first introduced in "Essential of Materia Medica" in 1694 in China. The most important bioactive components contained in P ginseng and P quinquefolium are ginseng saponins (GS). The contents of ginsen... | 18,718,179 |
Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. | Korean Panax ginseng C A Meyer is mainly used to maintain the homeostasis of the body, and the pharmacological efficacy of Korean ginseng identified by modern science includes improved brain function, pain-relieving effects, preventive effects against tumors as well as anti-tumor activity, enhanced immune system functi... | 18,718,180 |
Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. | To investigate the limiting factors for oral bioavailability of flavonoids derived from the Chinese herbal remedy Xiaochaihu-tang. The investigational flavonoids included baicalin, wogonoside, oroxylin-A 7-O-beta-Dglucopyranosiduronide, liquiritin, liquiritin apioside, isoliquiritin, and isoliquiritin apioside, as well... | 18,718,184 |
Cat-transmitted cutaneous lymphatic sporothricosis. | Sporotrichosis is the most common of the deep mycoses. In most cases the transmission occurs secondary to recent penetrating trauma with plant thorns, wood splinters or contaminated organic material. We report a case of a 68-year-old Brazilian female with a small ulcer on her right forefinger and palpable erythematous ... | 18,718,188 |
Neutrophilic dermatosis of the dorsal hands associated with hypopharyngeal carcinoma. | Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare and recently described disorder regarded as a subset of neutrophilic dermatosis, similar to superficial pyoderma gangrenosum and pustular vasculitis. Many currently consider it to be a localized variant of Sweet Syndrome. We describe the case of a 63-year-old... | 18,718,189 |
Cognitive impairment in schizophrenia: a review of developmental and genetic models, and pro-cognitive profile of the optimised D(3) > D(2) antagonist, S33138. | In vivo animal models are indispensable both for clarifying the pathological bases of schizophrenia, and for evaluating the potential benefits and disadvantages of novel therapy. Procedures that model mnemonic impairment are of particular interest since currently-available drugs do little to improve cognitive symptoms:... | 18,718,210 |
Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI. | To describe the computed tomography (CT) and magnetic resonance imaging (MRI) findings that differentiate solid pseudopapillary carcinomas (SPC) from benign solid pseudopapillary tumours (SPT) of the pancreas. Preoperative CT or MRI images for 26 patients (eight patients with SPC and 18 patients with SPT) were retrospe... | 18,718,230 |
Treatment of Takayasu's arteritis with tumor necrosis factor antagonists. | Four children with Takayasu's arteritis were treated with tumor necrosis factor antagonists because of disease relapse during conventional therapy or as a first-line agent. Two patients went into remission; in the other 2, the response was partial. Anti-tumor necrosis factor agents can have a role in the treatment of T... | 18,718,263 |
Extraocular proprioception and new treatments for infantile nystagmus syndrome. | Our goal is to develop the proprioceptive hypothesis for nystagmus damping; and present the resulting therapies for the treatment of infantile nystagmus syndrome (INS) and acquired nystagmus. Contact lenses, cutaneous stimulation, and neck-muscle vibration damped INS. Four-muscle tenotomy and reattachment was hypothesi... | 18,718,284 |
Supraspinal locomotor control in quadrupeds and humans. | Locomotion in humans and other vertebrates is based on spinal pattern generators, which are regulated by supraspinal control. Most of our knowledge about the hierarchical network of supraspinal locomotion centres derives from animal experiments, mainly in the cat. Here we summarize evidence that the supraspinal network... | 18,718,326 |
Supplementary eye field contributions to the execution of saccades to remembered target locations. | Multiple lines of evidence indicate that an anatomically discrete region within the dorsal medial frontal cortex--the supplementary eye field (SEF)--is involved in oculomotor control. To delineate this role further, repetitive transcranial magnetic stimulation (rTMS; 10 Hz, 500 ms) was administered either immediately a... | 18,718,335 |
Eye movements in visual search indicate impaired saliency processing in Parkinson's disease. | Previous studies have produced contradictory evidence on the nature of the visual search impairment in patients with Parkinson's disease (PD). Eye movements were measured during multi-target search in nine individuals with mild-to-moderate PD. Subjects were asked to click on a response button whenever they judged they ... | 18,718,353 |
Ocular motor anatomy in a case of interrupted saccades. | Saccades normally place the eye on target with one smooth movement. In late-onset Tay-Sachs (LOTS), intrasaccadic transient decelerations occur that may result from (1) premature omnipause neuron (OPN) re-activation due to malfunction of the latch circuit that inhibits OPNs for the duration of the saccade or (2) premat... | 18,718,354 |
The neuroanatomical basis of slow saccades in spinocerebellar ataxia type 2 (Wadia-subtype). | In a case of spinocerebellar ataxia type 2, Wadia-subtype (SCA2), with slow horizontal saccades, we used parvalbumin immunohistochemistry to identify the omnipause (OPNs) excitatory (EBNs), and inhibitory burst neurons (IBNs) of the saccade generator. Nissl sections was used to measure neuronal diameters, and synaptoph... | 18,718,357 |
The effect of mineral trioxide aggregate on the mineralization ability of rat dental pulp cells: an in vitro study. | The aim of this study was to investigate the effect of mineral trioxide aggregate (MTA) on cell viability and mineralization ability of rat dental pulp cells. The pulp capping materials, such as MTA, Dycal (Dentsply Caulk, Milford, DE), and Superbond C&B (SB; Sun Medical, Shiga, Japan) were placed on transwell inse... | 18,718,365 |
Nicotine inhibits mineralization of human dental pulp cells. | Nicotine is a major component of tobacco smoke, and signals via nicotinic acetylcholine receptors (nAChR). However, little is known about the effects of nicotine on human dental pulp cells (HDPCs). In this study, we assessed the effects of nicotine on mineralization in HDPCs. We confirmed messenger RNA expression of nA... | 18,718,366 |
An ex vivo evaluation of a gutta-percha filling technique when used with two endodontic sealers: analysis of the filling of main and lateral canals. | The aim of this study was to evaluate both the precision of filling and the extension of voids in main root canals as well as filling of lateral canals after using a two-phase filling technique with two sealers. Twenty-four maxillary and 26 mandibular molars were selected and randomly assigned to two groups. Root canal... | 18,718,375 |
Augmenting the antibiofilm efficacy of advanced noninvasive light activated disinfection with emulsified oxidizer and oxygen carrier. | In this study, we tested the hypothesis that the inclusion of an oxidizer and oxygen carrier in the photosensitization formulation would facilitate comprehensive disinfection of matured endodontic biofilm by light-activated disinfection (LAD). Photosensitizing formulations containing methylene blue (MB) and an oxygen c... | 18,718,378 |
Surgical management of advanced osteoarthritis of the temporomandibular joint with metal fossa-eminence hemijoint replacement: 10-year retrospective study. | To evaluate the surgical outcomes and clinical experience of the treatment of degenerative osteoarthritis of the temporomandibular joint with metal fossa-eminence hemijoint replacement. A retrospective chart review showed 99 patients (94 females and 5 males) who underwent treatment of degenerative joint disease with he... | 18,718,391 |
Piezoelectric printing and probing of Lectin NanoProbeArrays for glycosylation analysis. | Glycans have great potential as disease biomarkers and therapeutic targets. However, the major challenge for glycan biomarker identification from clinical samples is the low abundance of key glycosylated proteins. To demonstrate the potential for glycan analysis with nanoliter amounts of glycoprotein, we have developed... | 18,718,447 |
Maternal para-chlorophenylalanine exposure modifies central monoamines and behaviors in the adult offspring. | We reported a perspective animal model of neurodevelopmental disorders using rats prenatally exposed to an inhibitor of serotonin (5HT) synthesis, para-chlorophenylalanine (PCPA). Earlier, we demonstrated that prenatal exposure to PCPA caused fetal 5HT depletion and changes both in open field activity and in depression... | 18,718,452 |
Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. | It has been previously reported that an Asp421 cleaved form of tau is toxic when expressed in cells. The purpose of this study was to understand if, and in what manner, the presence of Asp421 cleaved tau in neurons, which is generated by caspase cleavage, might facilitate neuronal death in Alzheimer's disease (AD). For... | 18,718,455 |
Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart. | Morphine induces cardioprotection against ischaemia-reperfusion injury. While aiming to investigate the underlying signal transduction cascade of morphine preconditioning in isolated Langendorff-perfused rat hearts, the expected cardioprotection was not detectable. Thus, we investigated the influence of different preco... | 18,718,464 |
Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats. | A "neuroplastic" hypothesis proposes that changes in neuronal structural plasticity may underlie the aetiology of depression and the action of antidepressants. The medial prefrontal cortex (mPFC) is affected by this disorder and shows an intense expression of the polysialylated form of the neural cell adhesion molecule... | 18,718,470 |
Stable transfection of Eimeria tenella: constitutive expression of the YFP-YFP molecule throughout the life cycle. | The obligate intracellular apicomplexan parasite Eimeria tenella, one of seven species of Eimeria that infect chickens, elicits protective cell-mediated immunity against challenge infection. For this reason, recombinant E. tenella parasites could be utilised as an effective vaccine vehicle for expressing foreign antige... | 18,718,473 |
A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. | The actin cytoskeleton is critically involved in the regulation of the dendritic spine and synaptic properties, but the molecular mechanisms underlying actin dynamics in neurons are poorly defined. We took genetic approaches to create and analyze knockout mice specifically lacking ROCK2, a protein kinase that directly ... | 18,718,479 |
The sensory-discriminative and affective-motivational aspects of pain. | What is the difference between pain and standard exteroceptive perceptual processes, such as vision or audition? According to the most common view, pain constitutes the internal perception of bodily damage. Following on from this definition, pain is just like exteroceptive perception, with the only difference being tha... | 18,718,486 |
Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells. | The possibility of improving the efficacy of resveratrol, a polyphenol with strong antioxidant and free-radical scavenging properties, on cell proliferation and photoprotection by liposomal incorporation was investigated. Oligolamellar vesicles of different lipid compositions, loaded with resveratrol, were prepared and... | 18,718,515 |
Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. | Angelica sinensis is a Chinese medicinal herb for treating gynecological and gastrointestinal disorders, and also in conjunction with cancer chemotherapy. In the present study, the cytotoxic and anti-proliferative effects of three main Angelica sinensis phthalides, namely n-butylidenephthalide (BLP), senkyunolide A (SK... | 18,718,517 |
Telomerase deficiency promotes oxidative stress by reducing catalase activity. | Telomere shortening and redox imbalance have been related to the aging process. We used cultured mouse embryonic fibroblasts (MEF) isolated from mice lacking telomerase activity (Terc(-/-)) to analyze the redox balance and the functional consequences promoted by telomerase deficiency. Comparison with wild-type (WT) MEF... | 18,718,525 |
Catabolite repression control of flagellum production by Serratia marcescens. | Serratia marcescens is an emerging opportunistic pathogen with a remarkably broad host range. The cAMP-regulated catabolite repression system of S. marcescens has recently been identified and demonstrated to regulate biofilm formation through the production of surface adhesions. Here we report that mutations in compone... | 18,718,529 |
High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5. | Activating transcription factor 5 (ATF5) recently has been demonstrated to play a critical role in promoting the survival of human glioblastoma cells. Interference with the function of ATF5 in an in vivo rat model caused glioma cell death in primary tumors but did not affect the status of normal cells surrounding the t... | 18,718,539 |
Role of the prefrontal cortex in human balance control. | Although recent studies have demonstrated cortical involvement in human balance control, there is insufficient information regarding the regions of the cerebral cortex that contribute to human balance control and their mechanism of action. Using a functional near-infrared spectroscopic system, we investigated perturbat... | 18,718,542 |
Optimizing the design and analysis of clinical functional magnetic resonance imaging research studies. | With the widespread availability of functional magnetic resonance imaging (fMRI), there has been rapid progress in identifying neural correlates of cognition and emotion in the human brain. In conjunction with basic research studies, fMRI has been increasingly applied in clinical disorders, making it a central research... | 18,718,572 |
Feasibility of gastric electrical stimulation by percutaneous endoscopic transgastric electrodes. | Gastric electrical stimulation has been used for the treatment of drug refractory GI motility disorders and for the treatment of obesity. Both these indications have involved surgical placement of gastric electrodes, which adds to the complexity and cost of the procedure. Endoscopic placement is therefore an attractive... | 18,718,585 |
Women's opinions and experiences with induction of labor and cesarean delivery on request in south eastern Nigeria. | To assess the opinions and experiences of women regarding induction of labor and cesarean delivery on request in south eastern Nigeria. Women were interviewed using questionnaires on their awareness of their right to request labor induction and/or a cesarean delivery, and of their experience and opinion of the procedur... | 18,718,591 |
Hydrophobic interaction chromatography of proteins III. Transport and kinetic parameters in isocratic elution. | The effective pore diffusivities, D(e), of five model proteins (ribonuclease A, lysozyme, alpha-lactalbumin, ovalbumin, and BSA) in eight commercial phenyl hydrophobic interaction chromatography (HIC) media were determined by analyzing the plate height data from isocratic elution using the first two moments of the gene... | 18,718,599 |
Potential for activated persulfate degradation of BTEX contamination. | The present study focused on evaluation of activated persulfate (PS) anion (S(2)O(8)(2-)) oxidative degradation of benzene, toluene, ethylbenzene, and xylene (constituents of gasoline and known collectively as BTEX) contamination. The results indicated that BTEX were effectively oxidized by PS in aqueous and soil slurr... | 18,718,627 |
Electrogenerative gold recovery from cyanide solutions using a flow-through cell with activated reticulated vitreous carbon. | An electrogenerative flow-through reactor with an activated reticulated vitreous carbon cathode was developed. The influence of palladium-tin activation of the cathode towards gold deposition was studied by cyclic voltammetry. The reactor proved to be efficient in recovering more than 99% of gold within 4 h of operatio... | 18,718,637 |
Two girls with urethral duplication. | We present 2 cases of urethral duplication in girls, which has rarely been reported. Neither patient had any associated abnormalities. After a review of their clinical treatment and the current data on female urethral duplication, we recommend excision of the duplicated urethra and encourage diligent investigation in g... | 18,718,646 |
Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes. | Clinical data suggest that CD7+ myeloblasts are linked with poor prognosis in myeloid malignancies including myelodysplastic syndromes (MDS). To explore the biology behind this, we compared cell characteristics between CD34+CD7+ and CD34+CD7- myeloblasts from an MDS cell line and fresh samples from MDS patients. Compar... | 18,718,658 |
Cloning, nucleotide sequence and phylogenetic analyses, and tissue-specific expression of the transferrin gene in Cirrhinus mrigala infected with Aeromonas hydrophila. | Transferrin partial complementary DNAs were cloned from the livers of five species in four genera of Indian carps (Indian major carp species: Labeo rohita, Catla catla and Cirrhinus mrigala; medium carp: Puntius sarana; minor carp: Labeo bata) subsequent to polymerase chain reaction amplification with published heterol... | 18,718,662 |
Assessing reliability and validity of the Arabic language version of the Post-traumatic Diagnostic Scale (PDS) symptom items. | Arab immigrant women are vulnerable to post-traumatic stress disorder (PTSD) because of gender, higher probability of being exposed to war-related violence, traditional cultural values, and immigration stressors. A valid and reliable screen is needed to assess PTSD incidence in this population. This study evaluated the... | 18,718,671 |
The relation between anger management style, mood and somatic symptoms in anxiety disorders and somatoform disorders. | The objective of this study was to examine the relationship between anger management style, depression, anxiety and somatic symptoms in anxiety disorder and somatoform disorder patients. The subjects comprised 71 patients with anxiety disorders and 47 with somatoform disorders. The level of anger expression or anger su... | 18,718,675 |
Cardiac computed tomographic angiography for risk stratification and prediction of late cardiovascular outcome events in patients with a chest pain syndrome. | Contrast-enhanced multidetector cardiac computed tomographic angiography (CCTA) has high sensitivity and specificity for diagnosing anatomic coronary stenoses, but its role in predicting late clinical outcome events has not been well studied. We examined predictive value of CCTA for late major adverse cardiovascular (C... | 18,718,681 |
Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives. | Some new substituted tetrahydroacridin-8-ones and diverse derivatives were synthesized by uncatalysed multi-component reaction of dimedone or cyclohexan-1,3-dione, alpha-naphthylamine and various (o,p,m)-substituted benzaldehydes. The in vitro anti-microbial activities of the prepared compounds were evaluated against s... | 18,718,695 |
Safety and efficacy of transcatheter closure of atrial septal defects guided by transthoracic echocardiography: a prospective study from two Chinese Medical Centers. | The purpose of this study was to evaluate the safety and efficacy of transcatheter atrial septal defect (ASD) closure guided by transthoracic echocardiography (TTE). A total of 191 patients with ASD were recruited from two Chinese medical centers and TTE was carefully performed in multiple views to observe ASD number, ... | 18,718,698 |
Patterns and trends in injuries due to chemicals based on OSHA occupational injury and illness statistics. | The Occupational Safety and Health Administration (OSHA) and the Bureau of Labor Statistics (BLS) provide the Survey of Occupational Illness and Injury (SOII) statistics from 1992 to 2006, which is often used to measure the rate of injuries and illness in industry. The present system of gathering and classifying this d... | 18,718,716 |
The postmortem examination of President Kennedy is invalid: the evidence. | This paper proves that President Kennedy's postmortem examination is a sham. The sham nature of the presidential autopsy is based upon several findings incompatible with human anatomy, practice of medicine and Newton's second law "an object acted upon by a constant force will move with constant acceleration in the dire... | 18,718,721 |
Molecular and phenotypic characterization of Vibrio aestuarianus subsp. francensis subsp. nov., a pathogen of the oyster Crassostrea gigas. | Eleven Vibrio isolates invading the hemolymph of live and moribund oysters (Crassostrea gigas) collected in the field and from a hatchery in France, were characterized by a polyphasic approach. Phylogenetic analysis of 16S rRNA, gyrB and toxR genes indicated high homogeneity between these strains and the Vibrio aestuar... | 18,718,730 |
Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes. | This study evaluated the glycemic, insulinemic, and glucagon-like peptide-1 (GLP-1) responses of subjects with type 2 diabetes mellitus to consumption of two diabetes-specific tube-feeding formulas (slowly digested carbohydrate formula [SDC] and diabetes-specific formula [DSF]) and one formula intended for individuals ... | 18,718,737 |
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