title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Enhancement of risk of tick-borne infection: environmental and parasitological aspects of the problem. | The appearance of phenotypic (and probably genetic) exoskeleton anomalies in Ixodes ticks, first discovered and described elsewhere, seems to be a global phenomenon clearly related to environment pollution by heavy metal ions. These external markers of cadmium accumulation in the tick indicate an enhanced risk of tick-... | 18,714,886 |
Death and hypnosis: two remarkable cases. | The Journal of the American Medical Association reported The First Recorded Death in Hypnosis in its issue of October 27, 1894. Ninety-nine years later, on September 23, 1993 a healthy 24-year old mother of two was found dead at home, fully clothed and draped across the foot of one of her children's bed, 5 hours after ... | 18,714,893 |
Knowledge translation in the context of Aboriginal health. | Interest in the concept of knowledge translation (KT), one of the many terms used to describe the process(es) through which knowledge is transformed into action, is increasingly prevalent in the mainstream health literature. Despite a pressing need, little has been done to address the implications of evolving theories ... | 18,714,896 |
History of childhood abuse and neglect and suicidal behavior at hospital admission. | Suicide is a major public health problem. Preventive measures have been sought by identifying risk factors. This study evaluates the association of childhood abuse and neglect with suicidal behavior at the time of psychiatric hospital admission. A total of 120 subjects (72 females; mean age 42.5 +/- 15.6 years old) adm... | 18,714,912 |
Cross sectional survey of ultrasound use for central venous catheter insertion among resident physicians. | Use of ultrasound guidance for Central Venous Catheter insertion has been associated with decreased complications and increased success rates. Previous reports show low rates of use among physicians. Evaluation of the frequency of Ultrasound Guidance use for Central Venous Catheter insertion among residents at a teachi... | 18,714,916 |
Comparative clinical study of a subepithelial connective tissue graft and acellular dermal matrix graft for the treatment of gingival recessions: six- to 12-month changes. | Different techniques have been proposed for the treatment of gingival recession. This study compared the clinical results of gingival recession treatment using a subepithelial connective tissue graft and an acellular dermal matrix allograft. Seven patients with bilateral Miller class I or II gingival recession were sel... | 18,714,934 |
An experimental and theoretical study of NSCl decomposition in the presence of trace amounts of water. | An experimental and density functional theory study of the decomposition reaction of NSCl with water molecule(s) into NH 3 and SO 2 is described. Experiments involving the decomposition of NSCl in the presence of trace amounts of water showed that the formation of both HNSO and SO 2 is faster when the cell and the cell... | 18,714,953 |
Reactions over multiple, interconnected potential wells: unimolecular and bimolecular reactions on a C3H5 potential. | In this article we analyze quantitatively and discuss in detail a number of reactions that take place on a C3H5 potential. These reactions include the reaction of hydrogen atoms with allene and propyne, the reaction of methyl with acetylene, the isomerization of cyclopropyl to allyl, and the dissociation of allyl, 1-pr... | 18,714,954 |
No-pair bonding in coinage metal dimers. | High-level ab initio calculations at the coupled cluster with single and double substitutions and perturbative treatment of triple substitutions, CCSD(T), level of theory have been carried out for the dimers of coinage metal atoms Cu, Ag, and Au in the ground 1Sigma(g)+ state and in the excited 3Sigma(u)+ state. All of... | 18,714,956 |
Experimental bond critical point and local energy density properties determined for Mn-O, Fe-O, and Co-O bonded interactions for tephroite, Mn2SiO4, fayalite, Fe2SiO4, and Co2SiO4 olivine and selected organic metal complexes: comparison with properties calculated for non-transition and transition metal M-O bonded inter... | Bond critical point (bcp) and local energy density properties for the electron density (ED) distributions, calculated with first-principle quantum mechanical methods for divalent transition metal Mn-, Co-, and Fe-containing silicates and oxides are compared with experimental model ED properties for tephroite, Mn 2SiO 4... | 18,714,960 |
Direct determination of trace elements in powdered samples by in-cell isotope dilution femtosecond laser ablation ICPMS. | A method has been developed for the direct and simultaneous multielement determination of Cu, Zn, Sn, and Pb in soil and sediment samples using femtosecond laser ablation inductively coupled plasma mass spectrometry (fs-LA-ICPMS) in combination with isotope dilution mass spectrometry (IDMS). The in-cell isotope dilutio... | 18,714,966 |
Intermolecular, catalytic asymmetric hydroamination of bicyclic alkenes and dienes in high yield and enantioselectivity. | A set of catalytic, intermolecular hydroaminations of strained bicyclic olefins and dienes are reported that occur in both high yield and high enantioselectivity. These reactions occur with a catalyst generated from [Ir(cyclooctene)Cl]2, sterically hindered and electron-rich derivatives of the Segphos and BIPHEP family... | 18,715,004 |
Stereoselective iterative one-pot synthesis of N-glycolylneuraminic acid-containing oligosaccharides. | The use of an N-acyloxazolidinone-protected S-adamantanyl thiosialoside allows the highly stereoselective, one-pot multicomponent synthesis of alpha-sialoside-based oligosaccharides. | 18,715,011 |
Multiplexed affinity-based protein complex purification. | Here we proved the principle of a multiplexed affinity-based protein complex purification (MAPcP) technique that targets simultaneous extraction of multiple protein complexes with superior purity. Microspheres of various sizes and coupled with different affinity probes extract several protein complexes concurrently and... | 18,715,017 |
Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. | Parallel chemical and phylogenetic investigation of a marine cyanobacterium from Panama led to the isolation of two new PKS-NRPS-derived compounds, viridamides A and B. Their structures were determined by NMR and mass spectroscopic methods, and the absolute configurations assigned by Marfey's method and chiral HPLC ana... | 18,715,036 |
Phase-separation transition in liquid mixtures near curved charged objects. | We study the thermodynamic behavior of nonpolar liquid mixtures in the vicinity of curved charged objects, such as electrodes or charged colloids. There is a critical value of charge (or potential), above which a phase-separation transition occurs, and the interface between high- and low-dielectric constant components ... | 18,715,044 |
On a partial differential equation method for determining the free energies and coexisting phase compositions of ternary mixtures from light scattering data. | In this paper we present a method for determining the free energies of ternary mixtures from light scattering data. We use an approximation that is appropriate for liquid mixtures, which we formulate as a second-order nonlinear partial differential equation. This partial differential equation (PDE) relates the Hessian ... | 18,715,050 |
Closed-shell coupled-cluster theory with spin-orbit coupling. | A two-component closed-shell coupled-cluster (CC) approach using relativistic effective core potentials with spin-orbit coupling included in the post-Hartree-Fock treatment is proposed and implemented at the CC singles and doubles (CCSD) level as well as at the CCSD level augmented by a perturbative treatment of triple... | 18,715,057 |
Calculation of the transport and relaxation properties of methane. I. Shear viscosity, viscomagnetic effects, and self-diffusion. | Transport properties of pure methane gas have been calculated in the rigid-rotor approximation using the recently proposed intermolecular potential energy hypersurface [R. Hellmann et al., J. Chem. Phys. 128, 214303 (2008)] and the classical-trajectory method. Results are reported in the dilute-gas limit for shear visc... | 18,715,064 |
The structural and electronic properties of In(n)N(n = 1-13) clusters. | The structural and electronic properties of In(n)N(n=1-13) clusters have been investigated by density-functional theory with the generalized gradient approximation. The results indicate that the equilibrium structures of In(n)N are linear for n=1,2, planar for n=3-5, and three dimensional for n=6-13. Maximum peaks were... | 18,715,072 |
Rotational dynamics and polymerization of C60 in C60-cubane crystals: a molecular dynamics study. | We report classical and tight-binding molecular dynamics simulations of the C(60) fullerene and cubane molecular crystal in order to investigate the intermolecular dynamics and polymerization processes. Our results show that, for 200 and 400 K, cubane molecules remain basically fixed, presenting only thermal vibrations... | 18,715,084 |
Quasibinary amorphous phase in a three-dimensional system of particles with repulsive-shoulder interactions. | We report a computer-simulation study of the equilibrium phase diagram of a three-dimensional system of particles with a repulsive-step potential. Using free-energy calculations, we have determined the equilibrium phase diagram of this system. At low temperatures, we observe a number of distinct crystal phases. However... | 18,715,090 |
Interactions between polymer brushes in solvents of variable quality: a density functional theory study. | We present a density functional theory study of interactions between sterically stabilized colloidal particles in solvents of variable quality. Both flat and spherical polymer brushes are considered, as well as both monatomic and polymeric solvents. It is shown that the interaction between sterically stabilized particl... | 18,715,103 |
X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy. | In this work, the chemical changes in calf thymus DNA samples were analyzed by X-ray photoelectron spectroscopy (XPS). The DNA samples were irradiated for over 5 h and spectra were taken repeatedly every 30 min. In this approach the X-ray beam both damages and probes the samples. In most cases, XPS spectra have complex... | 18,715,106 |
The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. | Cell fate can be determined by asymmetric segregation of gene expression regulators. In the budding yeast Saccharomyces cerevisiae, the transcription factor Ace2 accumulates specifically in the daughter cell nucleus, where it drives transcription of genes that are not expressed in the mother cell. The NDR/LATS family p... | 18,715,118 |
Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. | Mesenchymal stem cells (MSCs) are defined by their ability to self-renew and differentiate into the cells that form mesodermal tissues such as bone and fat. Low magnitude mechanical signals (LMMS) have been shown to be anabolic to bone and have been recently reported to suppress the development of fat in normal animals... | 18,715,135 |
APE1/Ref-1: versatility in progress. | Apurinic/apyrimidinic endonuclease1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression. Over the past decade and a half, knowledge of the biological functions, interactions, mechanisms of action, and regulation of the protei... | 18,715,142 |
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat. | Previous reports have shown that the human immunodeficiency virus (HIV) regulatory protein Tat has both pro-oxidant and pro-inflammatory properties, suggesting that Tat might contribute to the neurological complications of HIV. However, the intracellular mechanisms whereby Tat triggers free radical production and infla... | 18,715,150 |
Extensively drug-resistant Mycobacterium tuberculosis during a trend of decreasing drug resistance from 2000 through 2006 at a Medical Center in Taiwan. | Drug resistance rates are one of the most important aspects in the national tuberculosis (TB) control program, and drug-resistant TB, especially extensively drug-resistant (XDR) TB, is not well understood in Taiwan. The objectives of this study were to investigate the prevalence of drug resistance from 2000 through 200... | 18,715,157 |
Skin findings in palliative care patients. | The prevalence of dermatologic disease and its effect on quality of life has not been well studied in patients with advanced illness. We sought to describe skin findings in inpatient palliative care patients and determine how often they are addressed by the primary or palliative care teams. We collected patient demogra... | 18,715,173 |
Immunogenicity of human and bovine insulin in type 1 diabetes mellitus patients. | The advantages of synthetic insulin (human insulin) over bovine insulin in the treatment of type 1 diabetes mellitus (DM) are much debated in terms of potency and purity. Immunogenicity is one of several factors that determine potency and safety. This study was designed to investigate and study the difference in immuno... | 18,715,205 |
Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase. | A series of 15 cinnamoyl triazole derivatives was prepared by Cu(I)-catalyzed azide/alkyne [3+2]-cycloaddition reactions and examined as inhibitors of guinea-pig liver transglutaminase. Several compounds exhibited activity as reversible inhibitors that were competitive with acyl donor transglutaminase substrates. For e... | 18,715,232 |
Red 'Anjou' pear has a higher photoprotective capacity than green 'Anjou'. | Photoprotective function of anthocyanins along with xanthophyll cycle and antioxidant system in fruit peel was investigated in red 'Anjou' vs green 'Anjou' pear (Pyrus communis) during fruit development and in response to short-term exposure to high light. The sun-exposed peel of red 'Anjou' had higher maximum quantum ... | 18,715,235 |
Comparisons of the responses of anterior and posterior human adult male bladder neck smooth muscle to in vitro stimulation. | To evaluate differing methods of stimulation on strips of human bladder neck smooth muscle and compare muscle taken from the anterior and posterior aspects. Samples of adult human male bladder neck muscle were obtained from patients undergoing open radical prostatectomy. Muscle was taken from either the anterior or pos... | 18,715,248 |
Traumatic neuromas of the penis: a clinical, histopathological and immunohistochemical study of 17 cases. | We present 17 penile traumatic neuromas. The mean patient age at presentation was 38 years (range 23-59 years). The most common site involved was the penile shaft. The lesions ranged from 1 to 7 mm in greatest dimension. The clinical diagnosis in all cases included condyloma acuminatum. In all cases, a history of traum... | 18,715,252 |
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. | As axons myelinate, establish a stable neurofilament network, and expand in caliber, neurofilament proteins are extensively phosphorylated along their C-terminal tails, which is recognized by the monoclonal antibody, RT-97. Here, we demonstrate in vivo that RT-97 immunoreactivity (IR) is generated by phosphorylation at... | 18,715,269 |
Pseudopelade of Brocq. | Pseudopelade of Brocq (PPB) is a rare, idiopathic, slowly progressive hair disorder, resulting in cicatricial alopecia. It typically presents in Caucasian adult patients as small, smooth, flesh-toned and slightly depressed alopecic patches with irregular outlines. It primarily involves the parietal and vertex portions ... | 18,715,295 |
The 'Act when Mild' (AwM) study: a step forward in our understanding of early treatment in acute migraine. | An important issue in the management of migraine is the advice given to patients as to when to take their treatment in the course of the attack. While it seems common sense almost to take treatment early in the attack, the evidence base for that advice is not as robust as could be expected. The 'Act when Mild' (AwM) St... | 18,715,331 |
Attitude: a concept analysis. | This paper presents a concept analysis conducted as a beginning step to developing research on nurses' attitudes toward advancing formal education. A literature review, conducted by the author, confirmed that the term attitude is used prolifically in nursing research; however, the findings were inconclusive as to a def... | 18,715,347 |
Cerebral palsy and restricted growth status at birth: population-based case-control study. | To evaluate the association between growth status at birth and subsequent development of cerebral palsy in preterm and term infants. Population-based case-controlled study. Cerebral palsy register in Western Sweden. Subjects Cohort of 334 singletons born between 1983 and 1990, with cerebral palsy diagnosed from age 4, ... | 18,715,410 |
High isoprostane level in cardinal ligament-derived fibroblasts and urine sample of women with uterine prolapse. | We studied the isoprostane level, a well-recognised biomarker of oxidative stress, from women with uterine prolapse and age-matched female controls without prolapse. Cardinal ligament-derived fibroblasts explanted from women with prolapse showed a significant increased level of isoprostane production (P < 0.05) comp... | 18,715,436 |
Persistent sinus venosus valve requiring surgery in children. | To review our experience with cardiac surgery due to remnants of the sinus venosus valve. We performed a retrospective evaluation of patients records during the period from 1980 to 2007. Three patients underwent surgical removal of the redundancy of the right sinus venosus valve. Remnants of the embryologic sinus venos... | 18,715,458 |
Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome. | We sought to define what clinical parameters were related to the ultimate outcome in Fontan patients who had developed protein-losing enteropathy (PLE). PLE is a serious complication of the Fontan operation. Several preoperative and perioperative findings are associated with later PLE. However, there is limited informa... | 18,715,460 |
Atypical mycobacterial infection in sequestrated lung in an infant presenting with chronic pneumonitis and recurrent wheezing. | An infant was referred to us for persistent cough and recurrent wheezing. Chest X-ray showed an abnormal shadow in the right lower lobe. A volumetric contrast-enhanced computerized tomography (CT) scan of the chest revealed an abnormal blood vessel extending from the descending aorta to the right lower lobe and anomalo... | 18,715,463 |
Coronary recanalization due to presumed thrombosis following surgical ligation of a large right coronary artery to right ventricle fistula. | We report angiographic findings in an infant with congestive heart failure due to a large right coronary artery to right ventricular fistula who underwent surgical ligation. Repeat catheterization 2 years later unexpectedly showed extensive thrombosis of the right coronary artery with multiple recanalized channels supp... | 18,715,466 |
Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia. | Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy. Anticoagulation in pediatric patients with HIT is challenging as there are no approved heparin substitutes. We report the use of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass in an infant with do... | 18,715,467 |
Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation. | The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by par... | 18,715,470 |
The theory of planned behaviour in medical education: a model for integrating professionalism training. | Teaching and evaluating professionalism remain important issues in medical education. However, two factors hinder attempts to integrate curricular elements addressing professionalism into medical school training: there is no common definition of medical professionalism used across medical education, and there is no com... | 18,715,476 |
Expectation and experience: dissonances between novice and expert perceptions in medical education research. | There is both qualitative and quantitative variation in the research methods training provided for Masters and doctoral students on medical education programmes across the UK. Unlike other higher-degree programmes, there are no requirements for higher-degree medical education students to have studied the subject at deg... | 18,715,483 |
Critical role for BIM in T cell receptor restimulation-induced death. | Upon repeated or chronic antigen stimulation, activated T cells undergo a T cell receptor (TCR)-triggered propriocidal cell death important for governing the intensity of immune responses. This is thought to be chiefly mediated by an extrinsic signal through the Fas-FasL pathway. However, we observed that TCR restimula... | 18,715,501 |
Genetic structure and breeding system in a social wasp and its social parasite. | Social insects dominate ecological communities because of their sophisticated group behaviors. However, the intricate behaviors of social insects may be exploited by social parasites, which manipulate insect societies for their own benefit. Interactions between social parasites and their hosts lead to unusual coevoluti... | 18,715,511 |
Models and mechanisms of energy balance regulation in the young. | The proportion of the child and adolescent population that is in appropriate energy balance is declining throughout the developed world, and childhood obesity is a particular problem in the UK relative to other northern European countries. Assessment of the underlying causes of obesity, and the different routes to its ... | 18,715,517 |
Echinococcus granulosus strain differentiation in Iran based on sequence heterogeneity in the mitochondrial 12S rRNA gene. | Parasite strain characterization is essential for the establishment of a prevention and control strategy in any endemic area. The aim of this study was to characterize different Echinococcus granulosus isolates from Iran by using DNA sequences of the mitochondrial 12S rRNA gene. Thirty livers and lungs of cattle, sheep... | 18,715,523 |
Arrhythmogenic right ventricular cardiomyopathy/dysplasia: an update. | Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a genetic cardiomyopathy characterized by ventricular arrhythmias and structural abnormalities of the right ventricle (RV). The diagnosis is based on the International Task Force criteria. Cardiologists may not be aware of these diagnostic criteria f... | 18,715,533 |
Current concepts in the evaluation and management of syncope. | Syncope is a very common presentation with a wide differential diagnosis and equally wide prognostic implications. Recent work has highlighted the importance of an accurate history and physical examination as the basis of diagnosis, prognosis, and treatment. Several centers have evaluated the role of structured histori... | 18,715,535 |
Prospective followup in patients after complete primary repair of bladder exstrophy. | The new technique of complete primary repair of bladder exstrophy has offered the promise of improved bladder functional outcomes and yet longitudinal followup in patients with exstrophy who have undergone this form of closure is sparse. We present our median 5-year data on patients who have undergone complete primary ... | 18,715,576 |
Adding renal scan data improves the accuracy of a computational model to predict vesicoureteral reflux resolution. | We previously developed a computational model to predict vesicoureteral reflux resolution 1 and 2 years after diagnosis. Previous studies suggest that an abnormal renal scan may be a predictor of the failure of vesicoureteral reflux to resolve. We investigated whether the addition of renal scan data would improve the a... | 18,715,584 |
Detection of papillomaviral DNA sequences in a feline oral squamous cell carcinoma. | Oral squamous cell carcinomas (OSCCs) are common and often fatal feline neoplasms. Factors that predispose to neoplasm development in cats are poorly defined. Around 25% of human OSCCs are caused by papillomaviruses (PVs). To determine if PVs are associated with OSCCs in cats, three sets of consensus primers were used ... | 18,715,602 |
Evaluation of carbon degradation during co-composting of exhausted grape marc with different biowastes. | In this work the carbon biodegradation of exhausted grape marc (EGM) combined with other organic wastes using the turned pile composting system was studied. Four different piles were made of EGM in Pile 1, EGM mixed with cow manure and straw (CMS) in Pile 2, EGM mixed with municipal solid waste (MSW) in Pile 3 and EGM ... | 18,715,609 |
Synthesis, antibacterial and anticonvulsant evaluations of some cyclic enaminones. | Several cyclic enaminone esters were synthesized, characterized, and evaluated for anticonvulsant and antibacterial activities using standardized tests. A series of enaminones were mainly phenyl analogs of anticonvulsant enaminones, while a second series comprised of compounds bearing the oxazolidinone pharmacophoric m... | 18,715,680 |
What is the best technique for urethroplasty? | There is no clear evidence that determines which type of urethroplasty to perform under which particular circumstance. To review the options for urethroplasty at different sites in the urethra and for different types of stricture indicating which procedure should be used in which circumstances according to the best ava... | 18,715,692 |
Observation of three-dimensional elemental distributions of a Si device using a 360 degrees -tilt FIB and the cold field-emission STEM system. | A technique for preparation of a pillar-shaped specimen and its multidirectional observation using a combination of a scanning transmission electron microscope (STEM) and a focused ion beam (FIB) instrument has been developed. The system employs an FIB/STEM compatible holder with a specially designed tilt mechanism, wh... | 18,715,717 |
[Yellow fever vaccination in non-immunocompetent patients]. | Any person travelling in countries where yellow fever (YF) is endemic and without presenting contra-indication for the vaccination against YF may be vaccinated. This vaccination can very rarely induce a potentially lethal neurotropic or viscerotropic disease. In severely immunodeficient patients, the vaccination is con... | 18,715,730 |
Predictors of refusal during a multi-step recruitment process for a randomized controlled trial of arthritis education. | Randomized controlled trials in patient education often have difficulty enrolling vulnerable populations-specifically, older, poorer, and less educated individuals. We undertook a randomized controlled trial (RCT) of an educational intervention for arthritis management, which included strategies to remove literacy-rela... | 18,715,740 |
A new method to induce multi-drug resistance to carboplatin in a mouse model of human tongue squamous cell carcinoma. | Multi-drug resistance (MDR) in human head and neck squamous cell carcinoma (HNSCC) constitutes a major obstacle to the effectiveness of chemotherapy. In previous studies, MDR was mainly induced in vitro. The authors report a novel in vivo method of inducing MDR in nude mice with xenotransplanted Tca8113 cells. Carbopla... | 18,715,753 |
Artificial consciousness: hazardous questions (and answers). | If human consciousness is the result of complex neural electro-chemical interactions occurring in the brain, the question of whether a machine can ever become self-aware could be a matter of time: the time necessary to fully understand the functional behavior of the brain structure, develop a mathematical model of it, ... | 18,715,771 |
Unravelling the tumor-suppressive functions of FOXO proteins. | Members of the forkhead box O (FOXO) family of transcription factors have been postulated to be tumor suppressors because of their established roles in cell-cycle arrest, apoptosis, DNA-damage repair and scavenging of reactive oxygen species. Recently, several animal model studies have shown that the FOXO proteins are ... | 18,715,783 |
Management of asymptomatic patients with severe non-ischaemic mitral regurgitation. Are practices consistent with guidelines? | For asymptomatic patients with severe mitral regurgitation, guidelines recommend surgery in selected patients. However, little is known on how the current practice fits with guidelines. Of the 5001 patients prospectively included in the Euro Heart Survey on valvular heart disease, 877 had isolated mitral regurgitation ... | 18,715,796 |
Phoenix Mars Mission--the thermal evolved gas analyzer. | The Phoenix spacecraft that was launched to Mars in August 2007 landed safely on the Martian northern arctic region on May 25, 2008. It carried six experiments to study the history of water on the planet and search for organic molecules in the icy subsurface Martian soil. The spacecraft is a lander with an arm and scoo... | 18,715,800 |
The relationship between dual energy X-ray absorptiometry (DXA) and DXA with laser (DXL) measurements in children. | The present study was designed to examine the relationship between bone mineral density (BMD) measurements performed using conventional dual energy X-ray absorptiometry (DXA) in total body (TB), spine, and hip and the more recent technique of DXA with laser (DXL) in the calcaneus in a young population and to explore th... | 18,715,809 |
Conditional survival rates of buccal and tongue cancer patients: how far does the benefit go? | The purpose of this study was to investigate the conditional survival probability in buccal and tongue cancer patients, and to identify the limit of increment in conditional survival probabilities after first diagnosis. This study retrospectively analyzed 339 consecutive patients with either buccal or tongue caner. The... | 18,715,814 |
Detection of LINE-1s hypomethylation in oral rinses of oral squamous cell carcinoma patients. | This study aimed to (i) investigate long interspersed nuclear element-1 (LINE-1) methylation levels of oral squamous cell carcinomas (OSCCs), the major type of oral malignancies; and (ii) investigate whether the hypomethylation of LINE-1s can be detected in oral rinses of OSCC patients. The combined bisulfite restricti... | 18,715,815 |
Insights into the catalytic mechanism of tyrosine phenol-lyase from X-ray structures of quinonoid intermediates. | Amino acid transformations catalyzed by a number of pyridoxal 5'-phosphate (PLP)-dependent enzymes involve abstraction of the Calpha proton from an external aldimine formed between a substrate and the cofactor leading to the formation of a quinonoid intermediate. Despite the key role played by the quinonoid intermediat... | 18,715,865 |
Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria. | Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting the motor neurons. The majority of familial forms of ALS are caused by mutations in the Cu,Zn-superoxide dismutase (SOD1). In mutant SOD1 spinal cord motor neurons, mitochondria develop abnormal morphology, bioenergetic defects, an... | 18,715,867 |
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. | Mutations in p97/VCP cause the multisystem disease inclusion body myopathy, Paget disease of the bone and frontotemporal dementia (IBMPFD). p97/VCP is a member of the AAA+ (ATPase associated with a variety of activities) protein family and has been implicated in multiple cellular processes. One pathologic feature in IB... | 18,715,868 |
The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency. | Iron is an essential nutrient that participates as a redox co-factor in a broad range of cellular processes. In response to iron deficiency, the budding yeast Saccharomyces cerevisiae induces the expression of the Cth1 and Cth2 mRNA-binding proteins to promote a genome-wide remodeling of cellular metabolism that contri... | 18,715,869 |
Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor. | ATP-sensitive K(+) (K(ATP)) channels modulate their activity as a function of inhibitory ATP and stimulatory Mg-nucleotides. They are constituted by two proteins: a pore-forming K(+) channel subunit (Kir6.1, Kir6.2) and a regulatory sulfonylurea receptor (SUR) subunit, an ATP-binding cassette (ABC) transporter that con... | 18,715,873 |
Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage. | Acetaminophen (AAP) is a commonly used analgesic and antipyretic drug; however, when used in high doses, it causes fulminant hepatic necrosis in both humans and experimental animals. In this study, we investigated whether selenium (Se) and N-acetylcysteine (NAC), alone or in combination, are protective against AAP toxi... | 18,715,889 |
Evidence for a role of connexin 43 in trigeminal pain using RNA interference in vivo. | The importance of glial cells in the generation and maintenance of neuropathic pain is becoming widely accepted. We examined the role of glial-specific gap junctions in nociception in the rat trigeminal ganglion in nerve-injured and -uninjured states. The connexin 43 (Cx43) gap-junction subunit was found to be confined... | 18,715,894 |
Three-dimensional organization of Rift Valley fever virus revealed by cryoelectron tomography. | Rift Valley fever virus (RVFV) is a member of the Bunyaviridae virus family (genus Phlebovirus) and is considered to be one of the most important pathogens in Africa, causing viral zoonoses in livestock and humans. Here, we report the characterization of the three-dimensional structural organization of RVFV vaccine str... | 18,715,915 |
Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. | Prion diseases such as scrapie involve the accumulation of disease-specific prion protein, PrP(Sc), in the brain. Toll-like receptors (TLRs) are a family of proteins that recognize microbial constituents and are central players in host innate immune responses. The TLR9 agonist unmethylated CpG DNA was shown to prolong ... | 18,715,916 |
Rh-PIP2;1, a rose aquaporin gene, is involved in ethylene-regulated petal expansion. | Aquaporins are water channel proteins that facilitate the passage of water through biological membranes and play a crucial role in plant growth. We showed that ethylene treatment significantly reduced petal size, inhibited expansion of petal abaxial subepidermal cells, and decreased petal water content in rose (Rosa hy... | 18,715,962 |
Development and validation of a prognostic scale for use in patients with advanced cancer. | The aim of this study was to develop a new prognostic indicator to help predict survival in advanced cancer patients more accurately. Data on 329 patients obtained from a multi-centre study in London were analysed. A multifactorial Cox regression model was applied and validated using bootstrapping techniques. Predictiv... | 18,715,969 |
Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. | Postoperative pain is the dominating complaint and the primary reason for prolonged convalescence after laparoscopic cholecystectomy. We have evaluated the efficacy of a single preoperative dose of pregabalin for attenuating postoperative pain and fentanyl consumption after laparoscopic cholecystectomy. Sixty adults (1... | 18,716,003 |
The inter-operator variability in measuring waist circumference and its potential impact on the diagnosis of the metabolic syndrome. | The International Diabetes Federation (IDF) has proposed ethnicity specific cut-off values for waist circumference, as an essential criterion for the diagnosis of the metabolic syndrome (MetS). However, before introducing waist circumference measurement as part of the clinical examination, or an obligatory criterion fo... | 18,716,012 |
Late reactivation of thyroid associated ophthalmopathy causing optic neuropathy. | We describe a case of thyroid associated ophthalmopathy complicated by optic neuropathy presenting 18 years after the diagnosis of dysthyroidism, due to late reactivation of a previously stable ophthalmopathy. | 18,716,022 |
Increased blood pressure in mice lacking cytochrome P450 2J5. | The cytochrome P450 (CYP) enzymes participate in a wide range of biochemical functions, including metabolism of arachidonic acid and steroid hormones. Mouse CYP2J5 is abundant in the kidney where its products, the cis-epoxyeicosatrienoic acids (EETs), modulate sodium transport and vascular tone. To define the physiolog... | 18,716,027 |
Aldose reductase genotypes and cardiorenal complications: an 8-year prospective analysis of 1,074 type 2 diabetic patients. | We report the independent risk association of type 2 diabetic nephropathy with the z-2 allele of the 5'-(CA)(n) microsatellite and C-106T promoter polymorphisms of the aldose reductase gene (ALR2) using a case-control design. In this expanded cohort, we examined their predictive roles on new onset of cardiorenal compli... | 18,716,049 |
Nontraumatic emergent neuroradiology: review and self-assessment module. | Objectiv: The educational objectives for this case-based self-assessment module on imaging of nontraumatic emergent neuroradiology are to use case examples to teach the imaging features of CT and MRI of emergent neuroradiologic diagnoses and to improve the reader's understanding of the pathophysiology and clinical mana... | 18,716,067 |
Contrast-enhanced sonographic guidance for local injection of a hemostatic agent for management of blunt hepatic hemorrhage: a canine study. | The purpose of this study was to determine whether injection of hemostatic agents directly into an injury site under the guidance of contrast-enhanced sonography can effectively control hemorrhage due to hepatic trauma. Fifteen mixed-breed dogs 2-3 years old and weighing 17-20 kg were anesthetized with intramuscular pe... | 18,716,077 |
Low-dose MDCT for surveillance of patients with severe homogeneous emphysema after bronchoscopic airway bypass. | The purpose of this study was to evaluate the usefulness of low-dose MDCT for radiologic monitoring of patients who have undergone placement of bronchial stents for airway bypass. In a prospective study, seven patients underwent MDCT according to a low-dose protocol (40 mAs, 120 kVp) before and after stent placement. T... | 18,716,078 |
In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI. | The purpose of this study was to investigate the in vivo morphologic and elastic parameters of trabecular bone with high-resolution 3-T MRI in a healthy reference population. A series of wrist MR images were acquired with high-spatial-resolution (180 mum) isotropic voxels from 40 subjects without reported bone disease.... | 18,716,099 |
CT of the normal esophagus to define the normal air column and its extent and distribution. | This study was designed to quantify and characterize the air-containing thoracic esophagus on CT to help diagnose diseases and facilitate correlation with lung diseases that may be associated with aspiration. The maximal air-containing esophageal lumina on each section of standard CT scans of 110 subjects were measured... | 18,716,104 |
Imaging of the brachiocephalic vein. | The purpose of this study was to review the imaging features of congenital variants of and pathologic conditions affecting the brachiocephalic vein. CT and MRI are excellent for visualizing developmental anomalies and mediastinal tumors that involve the brachiocephalic vein. Although they affect this vein less commonly... | 18,716,126 |
Prenatal diagnosis of placenta accreta: sonography or magnetic resonance imaging? | The purpose of this study was to compare the accuracy of transabdominal sonography and magnetic resonance imaging (MRI) for prenatal diagnosis of placenta accreta. A historical cohort study was undertaken at 3 institutions identifying women at risk for placenta accreta who had undergone both sonography and MRI prenatal... | 18,716,136 |
Nomograms of the axial transverse diameter of the fetal foramen magnum between 14 and 40 weeks' gestation. | The purpose of this study was to create reference range nomograms of the axial transverse diameter of the fetal foramen magnum (TDFM) between 14 and 40 weeks' gestation. This cross-sectional study included pregnant patients between 14 and 41 weeks' gestation. Inclusion criteria consisted of well-established dates (conf... | 18,716,139 |
Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats. | Previous studies suggest that both overfeeding and undernutrition during development increase the risk of obesity and hypertension in adulthood. In this study, we examined both short- (24 d) and long- (16 wk) term effects of early postnatal over- and underfeeding in rats on body weight, body composition, plasma hormone... | 18,716,160 |
Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells. | Zinc may contribute to the host defense by maintaining the membrane barrier. In this study, we questioned whether zinc deficiency affects the membrane function and junctional structure of intestinal epithelial cells, causing increased neutrophil migration. We used the Caco-2 cell line grown in control (C), zinc-deficie... | 18,716,167 |
Adherence to dietary recommendations for saturated fat, fiber, and sodium is low in American Indians and other U.S. adults with diabetes. | The objective of this article was to evaluate how well American Indians with diabetes met dietary recommendations and to compare adherence to dietary recommendations with those of U.S. adults with diabetes in the NHANES. Dietary intake in both studies was assessed using a 24-h recall questionnaire. Dietary intakes were... | 18,716,172 |
Impact of peanuts and tree nuts on body weight and healthy weight loss in adults. | Nuts (ground and tree) are rich sources of multiple nutrients and their consumption is associated with health benefits, including reduced cardiovascular disease risk. This has prompted recommendations to increase their consumption. However, they are also high in fat (albeit largely unsaturated) and are energy dense. Th... | 18,716,179 |
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