title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Oriented films of layered rare-earth hydroxide crystallites self-assembled at the hexane/water interface. | Layered rare-earth hydroxide crystallites self-assembled at the hexane/water interface were transferred to various substrates to form a monolayer film, which exhibited photoluminescence properties and ion-exchange ability. | 18,931,731 |
Encapsulation of charge-diffuse peralkylated onium cations in the cavity of cucurbit[7]uril. | Cucurbit[7]uril binds, with considerable size selectivity, NR(4)(+), PR(4)(+), and SR(3)(+) cations (R=Me, Et, (n)Pr, (n)Bu), with the smaller guests inside its cavity, rather than at the carbonyl-lined portals. | 18,931,744 |
Solubility switch of gold nanoparticles through hydrogen bond association. | Gold nanoparticles (AuNPs) coated with hexafluoroisopropanol moieties were prepared, and their surface was changed through simple hydrogen bond association with various amines, which allow orientation of the solubility of these AuNPs in determined organic solvents. | 18,931,750 |
Repetitive lagging strand DNA synthesis by the bacteriophage T4 replisome. | Our studies on the T4 replisome build on the seminal work from the Alberts laboratory. They discovered essentially all the proteins that constitute the T4 replisome, isolated them, and measured their enzymatic activities. Ultimately, in brilliant experiments they reconstituted in vitro a functioning replisome and in th... | 18,931,782 |
Supramolecular helical porphyrin arrays using DNA as a scaffold. | A diphenyl porphyrin substituted nucleotide was incorporated site specifically into DNA, leading to helical stacked porphyrin arrays in the major groove of the duplexes. The porphyrins show an electronic interaction which is significantly enhanced compared to the analogous tetraphenyl porphyrin (TPP) as shown in the la... | 18,931,790 |
Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation. | Selective protein cleavage at methionine residues is a useful method for the production of bacterially derived protein fragments containing an N-terminal cysteine residue required for native chemical ligation. Here we describe an optimised procedure for cyanogen bromide-mediated protein cleavage, and ligation of the re... | 18,931,805 |
Transannular rearrangement of activated 2,5-diketopiperazines: a key route to original scaffolds. | An efficient and original stereocontrolled transannular rearrangement starting from activated 2,5-diketopiperazines has been developed, an opportunity for the medicinal chemistry field, which requests access to novel biological scaffolds. This powerful ring contraction, which can be related to a stereoselective aza-ver... | 18,931,807 |
An efficient synthesis of chiral phosphinyl oxide pyrrolidines and their application to asymmetric direct aldol reactions. | Chiral pyrrolidine-based phosphinyl oxides were synthesized and their performance as organocatalysts for asymmetric direct aldol reactions was evaluated. High enantioselectivities and diastereoselectivies were achieved for a range of cyclic ketones and aromatic aldehydes. | 18,931,808 |
Electrophilicity of aromatic triflones in sigma-complexation processes. | The kinetics of sigma-complexation of 2,6-bis(trifluoromethanesulfonyl)-4-nitroanisole (4) have been investigated over a large pH range of 2-15.68 in methanol. Two competitive processes have been identified with the initial addition of MeO(-) at the unsubstituted 3-position of 4 to give a 1,3-dimethoxy adduct (4b-Me) a... | 18,931,813 |
An unexpected epoxidation of benzil derivatives in their reaction with a germene. | The germene Mes(2)Ge=CR(2) (Mes = 2,4,6-trimethylphenyl, CR(2) = fluorenylidene) reacts with various benzil derivatives to lead to germanium-containing bicyclic epoxides by an unexpected new type of epoxidation reaction. | 18,931,816 |
The microstructure of cornea verticillata in Fabry disease and amiodarone-induced keratopathy: a confocal laser-scanning microscopy study. | The purpose of this study is to describe cornea verticillata in Fabry disease and in amiodarone-induced keratopathy and to compare the corneal microstructure of both types. Ten eyes from ten normal subjects, 28 eyes from 22 patients with Fabry disease confirmed by molecular genetic studies, and 16 eyes from 11 patients... | 18,931,853 |
Treatment of severe Henoch-Schönlein and immunoglobulin A nephritis. A single center experience. | Our aim was to report the effect of two treatment regimens in 43 cases of severe Henoch-Schönlein nephritis (HSN) and immunoglobulin A nephritis (IgAN) (24 HSN, 19 IgAN). Group A, 11 HSN and 7 IgAN, 88% with an International Study of Kidney Disease in Children (ISKDC) biopsy grade > or = III and severe clinical feat... | 18,931,859 |
Undertreatment of nausea and other symptoms in hospitalized cancer patients. | This survey aimed to provide a symptom profile, in particular for nausea and its treatment, of advanced cancer patients prior to implementation of a clinical practice guideline for nausea. An audit of 82 advanced cancer patients admitted to a major Australian teaching hospital was undertaken. While nausea was present i... | 18,931,863 |
A case of acute ischemic duodenal ulcer associated with superior mesenteric artery dissection after transarterial chemoembolization for hepatocellular carcinoma. | We report a case of transarterial chemoembolization (TACE)-related acute ischemic duodenal ulcer that developed in association with dissection of the superior mesenteric artery. We conclude that the acute duodenal ulcer was developed by ischemia related to superior mesenteric artery dissection during TACE. TACE should ... | 18,931,873 |
Patient dose reference levels for interventional radiology: a national approach. | A set of patient dose reference levels (RLs) for fluoroscopically guided interventional procedures was obtained in a survey launched by the National Society of Interventional Radiology (IR), involving 10 public hospitals, as recommended by the European Medical Exposures Directive. A sample of 1391 dose values (kerma ar... | 18,931,875 |
In search of a good death. | Spirituality and storytelling can be resources in aging successfully and in dying well given the constraints of modern day Western culture. This paper explores the relationship of aging to time and the dynamic process of the life course and discusses issues related to confronting mortality, including suffering, finitud... | 18,931,891 |
Ethnic, gender, and acculturation influences on sexual behaviors. | Much research has been conducted on ethnic differences in sexuality, but few studies have systematically assessed the importance of acculturation in sexual behavior. The present study assessed general differences in normative sexual practices in healthy Euro-American, Asian, and Hispanic populations, using measures of ... | 18,931,901 |
The NIfETy method for environmental assessment of neighborhood-level indicators of violence, alcohol, and other drug exposure. | There are limited validated quantitative assessment methods to measure features of the built and social environment that might form the basis for environmental preventive interventions. This study describes a model approach for epidemiologic assessment of suspected environmental determinants of violence, alcohol and ot... | 18,931,911 |
Quantification of urbanization in relation to chronic diseases in developing countries: a systematic review. | During and beyond the twentieth century, urbanization has represented a major demographic shift particularly in the developed world. The rapid urbanization experienced in the developing world brings increased mortality from lifestyle diseases such as cancer and cardiovascular disease. We set out to understand how urban... | 18,931,915 |
An in silico strategy identified the target gene candidates regulated by dehydration responsive element binding proteins (DREBs) in Arabidopsis genome. | Identification of downstream target genes of stress-relating transcription factors (TFs) is desirable in understanding cellular responses to various environmental stimuli. However, this has long been a difficult work for both experimental and computational practices. In this research, we presented a novel computational... | 18,931,920 |
Subclinical coronary atherosclerosis and neighbourhood deprivation in an urban region. | Inhabitants of deprived neighbourhoods are at higher risk of coronary heart disease. In this study we investigate the hypothesis that social inequalities at neighbourhood level become already manifest in subclinical coronary atherosclerosis, as defined by electron-beam computed tomography derived measures. Coronary art... | 18,931,923 |
Defining useful surrogates for user participation in online medical learning. | "School for Surgeons" is a web-based distance learning program which provides online clinical-based tutorials to surgical trainees. Our aim was to determine surrogates of active participation and to assess the efficacy of methods to improve usage. Server logs of the 82 participants in the "School for Surgeons" were ass... | 18,931,929 |
Optimization of fermentation conditions for the biosynthesis of L-threonine by Escherichia coli. | In this study, the fed-batch fermentation technique was applied to improve the yield of L-threonine produced by Escherichia coli TRFC. Various fermentation substrates and conditions were investigated to identify the optimal carbon source, its concentration and C/N ratio in the production of L-threonine. Sucrose was fou... | 18,931,947 |
Engineering of cysteine residues leads to improved production of a human dipeptidase enzyme in E. coli. | Low yields, poor folding efficiencies and improper disulfide bridge formation limit large-scale production of cysteine-rich proteins in Escherichia coli. Human renal dipeptidase (MDP), the only human beta-lactamase known to date, is a homodimeric enzyme, which contains six cysteine residues per monomer. It hydrolyses p... | 18,931,951 |
Bioindication of trace metals in Brachythecium rutabulum around a copper smelter in Legnica (Southwest Poland): Use of a new form of data presentation in the form of a self-organizing feature map. | Concentrations of the elements Al, Be, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, V, and Zn were measured in the terrestrial moss Brachythecium rutabulum and the soil on which it grew. Soil and moss plants were sampled at sites situated 1.5, 3, 6, 9 and 15 km to the north, south, east and west of the Legnica copper smelter (SW Po... | 18,931,962 |
[New perspectives in the laboratory diagnosis of dementia]. | Over the past 10 years, the status of laboratory analysis in dementia has increasingly changed from its use for exclusion diagnoses for secondary causes of dementias to determining positive diagnoses of neurodegenerative dementias. This especially applies to the cerebrospinal fluid diagnosis of Alzheimer's disease (AD)... | 18,931,988 |
[Testosterone substitution with special regard to prostate cancer]. | Testosterone substitution is used to treat the symptoms of low testosterone in men who do not produce enough natural testosterone. Hypogonadism is associated with a range of disease states that have significant effects on morbidity and mortality and also affect quality of life. The regular investigation of PSA, prostat... | 18,931,991 |
Combining microchip and cell technology for creation of novel biodevices. | Microchip technology has matured over the years into an important field in which novel technologies are being constantly invented, and down-sizing and incorporation of already existing methodologies into the microscale is increasing assay performance and bearing the promise of future total integration for simple, wides... | 18,931,993 |
Chiral separation of raltitrexed by cyclodextrin-modified micellar electrokinetic chromatography. | A rapid and effective method was developed for the chiral separation of raltitrexed (RD) enantiomers by carboxymethyl-beta-cyclodextrin (CM-beta-CD)-modified micellar electrokinetic chromatography (MEKC). Optimization of conditions including the type and concentration of the chiral selector, concentration of sodium dod... | 18,931,995 |
Association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene and bone mineral density: a meta-analysis. | The association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density (BMD) has been studied, but results have been mixed. Accordingly, the authors performed a meta-analysis on studies on the association between the A1330V LRP5 polymorphism and B... | 18,932,002 |
[Effect of dynamic hyperinflation on exertional dyspnea, exercise performance and quality of life in COPD]. | There is increasing evidence that dynamic hyperinflation (DH) have negative effects on exercise performance and quality of life in chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to investigate effect of dynamic hyperinflation on exertional dyspnea, exercise performance and quality of l... | 18,932,031 |
Effect of dietary alpha-ketoglutarate on blood lipid profile during hypercholesterolaemia in rats. | The aim of the study was to determine the effect of alpha-ketoglutarate on the blood lipid profile using a rat animal model with experimentally induced hypercholesterolaemia. The female and male (30/30) Wistar rats had ad libitum access to a diet containing cholesterol (1 %) and lard (10 %) throughout the entire experi... | 18,932,049 |
Seasonal variations in the chemical composition of vine-grape leaf surface. | Surface leaf metabolites of two seedlings of a Bulgarian winemaking cultivar Storgozia I(1) were analyzed in two seasons - summer (July) and autumn (October). The resistance towards some fungal pathogens of one of the plants was estimated as superior to the resistance of the other one. Significant seasonal variations i... | 18,932,086 |
Endoscopic approach to tensor fold in patients with attic cholesteatoma. | The endoscopic approach to attic cholesteatoma allows clear observation of the tensor fold area and consequently, excision of the tensor fold, modifying the epitympanic diaphragm. This permits good removal of cholesteatoma and direct ventilation of the upper unit, preventing the development of a retraction pocket or at... | 18,932,099 |
[Social inequality in medical rehabilitation]. | The association of social inequality and health is well known and well documented. Numerous studies have shown that a lower socio-economic status is associated with higher morbidity and mortality. This association is caused by various circumstances such as unfavourable work and living conditions, unhealthy life styles ... | 18,932,119 |
On the nosology and pathogenesis of Wolf-Hirschhorn syndrome: genotype-phenotype correlation analysis of 80 patients and literature review. | Based on genotype-phenotype correlation analysis of 80 Wolf-Hirschhorn syndrome (WHS) patients, as well as on review of relevant literature, we add further insights to the following aspects of WHS: (1) clinical delineation and phenotypic categories; (2) characterization of the basic genomic defect, mechanisms of origin... | 18,932,124 |
General solutions to multiple testing problems. Translation of "Sonnemann, E. (1982). Allgemeine Lösungen multipler Test probleme. EDV in Medizin und Biologie 13(4), 120-128". | The introduction of sequentially rejective multiple test procedures (Einot and Gabriel, 1975; Naik, 1975; Holm, 1977; Holm, 1979) has caused considerable progress in the theory of multiple comparisons. Emphasizing the closure of multiple tests we give a survey of the general theory and its recent results in application... | 18,932,150 |
Aesthetics and power considerations in multiple testing--a contradiction? | In this paper we discuss aesthetical concepts and requirements for reasonable multiple test procedures. Aesthetical considerations lead to logical decision patterns which are conceivable and, if possible, simple to use and to communicate. Such considerations are sometimes contradictory to the ubiquitous requirement of ... | 18,932,151 |
Ion-responsive behavior of ionic-liquid surfactant aggregates with applications in controlled release and emulsification. | We propose a simple but efficient, rapid, and quantitative ion-responsive micelle system based on counter-anion exchange of a surfactant with an imidazolium unit. The ion-exchange reaction results in the amphiphilic-to-hydrophobic transition of the imidazolium salt, leading to the destruction of the micelles, which has... | 18,932,155 |
The proximal promoter governs germ cell-specific expression of the mouse glutathione transferase mGstm5 gene. | To explain the tissue-selective expression patterns of a distinct subclass of glutathione S-transferase (GST), transgenic mice expressing EGFP under control of a 2 kb promoter sequence in the 5'-flanking region of the mGstm5 gene were produced. The intent of the study was to establish whether the promoter itself or whe... | 18,932,202 |
Staircase but not posttetanic potentiation in rat muscle after spinal cord hemisection. | Spinal cord hemisection (SCH) results in atrophy of skeletal muscle and altered contractile properties. In this study our purpose was to assess staircase and posttetanic potentiation in the rat gastrocnemius muscle in situ, 1 week after SCH. Tetanic force was reduced by SCH, but twitch amplitude was not. The time cours... | 18,932,208 |
Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. | STriatal Enriched protein tyrosine Phosphatase (STEP) is a brain-specific protein that is thought to play a role in synaptic plasticity. This hypothesis is based on previous findings demonstrating a role for STEP in the regulation of the extracellular signal-regulated kinase1/2 (ERK1/2). We have now generated a STEP kn... | 18,932,218 |
Altered netrin-1 receptor expression in dopamine terminal regions following neonatal ventral hippocampal lesions in the rat. | Neonatal ventral hippocampal (nVH) lesions in rats, which model certain features of schizophrenia, alter dopamine (DA)-mediated behaviors in adulthood. The precise mechanisms underlying these effects remain elusive; however, neuronal reorganization within the medial prefrontal cortex (mPFC) has been suggested. Netrins ... | 18,932,228 |
Clinical significance of low expression of Prostasin mRNA in human gastric cancer. | Prostasin is considered to have suppressive activities against tumor progression. The aim of this study was to clarify its clinical significance in gastric cancer. Tumor and the corresponding normal samples were prepared from a total of 108 gastric cancer patients. Prostasin expression was assayed by real time reverse ... | 18,932,242 |
Biochemical recurrence after radical prostatectomy for prevalent versus incident cases of prostate cancer : implications for management. | Among screened populations, it is unknown whether men with prostate cancer (PC) diagnosed at the initial screening (prevalent cases) have a different outcome than men who are diagnosed at subsequent screenings (incident cases) after adjusting for known prognostic factors. The current study cohort was comprised of 1923 ... | 18,932,254 |
Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. | To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis, spontaneous abortion, allo- and xeno- graft rejection by mediating "immune coagulation". Tumo... | 18,932,275 |
Is ineffective esophageal motility associated with gastropharyngeal reflux disease? | To evaluate the association between ineffective esophageal motility (IEM) and gastropharyngeal reflux disease (GPRD) in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms. A total of 632 patients who underwent endoscopy, esophageal manometry and ambulatory 24-... | 18,932,282 |
Endoscopic ultrasound-guided choledochoduodenostomy in patients with failed endoscopic retrograde cholangiopancreatography. | Endoscopic ultrasonography (EUS)-guided biliary drainage was performed for treatment of patients who have obstructive jaundice in cases of failed endoscopic retrograde cholangiopancreatography (ERCP). In the present study, we introduced the feasibility and outcome of EUS-guided choledochoduodenostomy in four patients w... | 18,932,289 |
Orthotopic heart transplantation: ten years' clinical experience. | Heart transplantation is the "gold standard" in the treatment of patients with end-stage heart failure who satisfy strict selection criteria. We reviewed ten years' clinical experience (1996-2006) from 53 orthotopic transplants in our centre. Low perioperative (3.7%) and long-term (7.5%) mortality rates yielded a 95% s... | 18,935,709 |
Health-related quality of life measurement in patients admitted with coronary heart disease and heart failure to a cardiology department of a secondary urban hospital in Greece. | The aim of this study was to measure the quality of life in patients with coronary heart disease and heart failure, who make up the majority of admissions to an acute hospital cardiology unit. The study was undertaken in the General Hospital of Agios Nikolaos, Crete, and recruited 153 patients. The SF-36 and EQ-5D ques... | 18,935,711 |
Abdominal aortic aneurysm in a renal transplant patient. | Repair of an abdominal aortic aneurysm in a renal transplant recipient poses many different problems due to warm ischaemia to the grafted kidney. This is a case of 50-year-old gentleman who had a pervious renal transplant with abdominal aortic aneurysm. To reduce the effects of warm ischaemia on the transplanted kidney... | 18,935,743 |
[Assessment of health related quality of life--Part 1--Direct measures]. | Assessment of the impact of medical interventions on patient's quality of life is becoming a major aspect in evaluating the effectiveness of these interventions. Based on the concept of combining life expectancy and quality of life in a single value, many tools for measuring this effect have been developed in the last ... | 18,935,765 |
Prevention of mother-to-child transmission of HIV: the Georgian experience. | The objective of this paper is to review experience in prevention of mother-to-child transmission (PMTCT) of HIV in Georgia. PMTCT is one of the strategic priorities in Georgia. The first case of HIV infection in pregnant women was reported in 1999. Starting 2005 the National Programme on PMTCT became operational. One ... | 18,935,779 |
Postoperative residual curarization: clinical observation in the post-anesthesia care unit. | Neuromuscular blocking agents (NMBAs) are widely used during the induction and maintenance of anesthesia. Postoperative residual curarization (PORC) following the use of NMBAs still occurs even though intermediate-acting NMBAs were used. Train-of-four (TOF) stimulation is used to quantify the degree of neuromuscular bl... | 18,935,794 |
Implantable hearing aids. | The aim of this article is to give readers a general overview of the concepts involved in the latest generation of implantable hearing aids. A section on ear biomechanics has also been included to familiarize readers with the basic concepts involved. These devices have been developed over the last 20 years, driven by p... | 18,935,801 |
Compliant layer bearings in artificial joints. Part 1: the effects of different manufacturing techniques on the interface strength between an elastomeric layer and a rigid substrate. | The premise that elastomeric materials could be used as one or more of the articulating components in both hip and knee prostheses was postulated first by Unsworth and co-workers. It was thought that such materials might have the capacity to mimic natural joint behaviour more closely than the more rigid bearing surface... | 18,935,802 |
Objective functional assessment of total hip arthroplasty following two common surgical approaches: the posterior and direct lateral approaches. | Despite the high number of total hip arthroplasty (THA) procedures performed each year, there is no common consensus on the best surgical approach. Gait is known to improve following THA although it does not return to what is typically quantified as normal, and surgical approach is believed to be a contributing factor.... | 18,935,806 |
A biomechanical assessment of the coupling of torsion and tension in the human scapholunate ligament. | The mechanical behaviour of human scapholunate ligaments is not well described in the literature with regard to torsion. In this study, intact scapholunate specimens were mechanically tested in torsion to determine whether a simultaneous tensile load was generated. Human intact scapholunate specimens (n = 19) were harv... | 18,935,807 |
Effect of curing characteristics on residual stress generation in polymethyl methacrylate bone cements. | Residual stresses resulting from the shrinkage of polymethyl methacrylate (PMMA) bone cement have been implicated in the formation of cracks in cement mantles following total hip arthroplasty. This study investigates whether two such cements, with differentiated solidification characteristics (i.e. working and setting ... | 18,935,810 |
Natural frequency analysis of tooth stability under various simulated types and degrees of alveolar vertical bone loss. | The aim of this study was to test natural teeth stability under various simulated types and degrees of alveolar vertical bone loss, as well as to assess the role that the surrounding bone played for maintaining tooth stability. A three-dimensional finite element model of the human maxillary central incisor with surroun... | 18,935,815 |
Laser-induced breakdown spectroscopy for analysis of chemically etched polytetrafluoroethylene. | Laser-induced breakdown spectroscopy (LIBS) is used to analyze chemically etched polytetrafluoroethylene (PTFE). The elements O, F, H, and Na are determined qualitatively in the depth dimension. It is shown that O, H, and Na signals are greatest at the surface and decrease as the laser burrows through the etched layer ... | 18,935,827 |
The lived experience and meaning of stress in acute mental health nurses. | While studies into stress in mental health nursing are small, studies specifically looking at acute mental health nurses are even fewer. Acute mental health nurses work in environments that are challenging and unpredictable, and care for some of the most seriously ill patients. This area, therefore, needs staff that ar... | 18,935,838 |
IV therapy: recognizing the differences between infiltration and extravasation. | Infiltration and extravasation are complications that can occur during intravenous therapy administered via either peripheral or central venous access devices. Both can result in problems with the siting of future venous access devices, nerve damage, infection and tissue necrosis. The nurse is the key to reducing the r... | 18,935,841 |
Is it "every man's right to have babies if he wants them"? Male pregnancy and the limits of reproductive liberty. | Since the 1980s, a number of medical researchers have suggested that in the future it might be possible for men to become pregnant. Given the role played by the right to reproductive liberty in other debates about reproductive technologies, it will be extremely difficult to deny that this right extends to include male ... | 18,935,924 |
Integrative holism in psychiatric-mental health nursing. | In this era of high-tech care, many Americans seek more holistic approaches and alternative and complementary treatments for health problems, including mental illness. Psychiatric-mental health (PMH) nurses need to be aware of these approaches as they assess clients, maintain a holistic approach, and in some cases, pro... | 18,935,934 |
Primary triage, evacuation priorities, and rapid primary distribution between adjacent hospitals--lessons learned from a suicide bomber attack in downtown Tel-Aviv. | Terrorist attacks have occurred in Tel-Aviv that have caused mass-casualties. The objective of this study was to draw lessons from the medical response to an event that occurred on 19 January 2006, near the central bus station, Tel-Aviv, Israel. The lessons pertain to the management of primary triage, evacuation priori... | 18,935,948 |
Preparedness of primary healthcare centers for critical emergency situations in southwest Turkey. | Primary healthcare centers (PHCCs) frequently are contacted for emergency reasons and are expected to provide basic and advanced life support during emergency situations. The aim of this study was to assess the availability of emergency equipment and the knowledge of the staff working in PHCCs. The survey was conducted... | 18,935,949 |
Accuracy of computer simulation to predict patient flow during mass-casualty incidents. | Although most hospitals have an emergency department disaster plan, most never have been implemented in a true disaster or been tested objectively. Computer simulation may be a useful tool to predict emergency department patient flow during a disaster. The aim of this study was to compare the accuracy of a computer sim... | 18,935,951 |
The public health dimension of disasters--health outcome assessment of disasters. | A broad range of health problems are related to disasters. Insight into these health problems is needed for targeted disaster management. Disaster health outcome assessment can provide insight into the health effects of disasters. During the 15th World Congress on Disaster and Emergency Medicine in Amsterdam (2007), ex... | 18,935,960 |
Saporin induces multiple death pathways in lymphoma cells with different intensity and timing as compared to ricin. | Ribosome-inactivating protein (RIP)-containing immunotoxins are currently used in clinical trials as anti-tumour drugs, in particular against haematological malignancies. In cell killing-based therapies it is important to identify the death pathways induced by the cytotoxic agent. The purpose of this work was to compar... | 18,935,973 |
Syndromes, disorders and maternal risk factors associated with neural tube defects (V). | Fetuses with neural tube defects (NTDs) may suffer from associated syndromes and disorders. This article provides a comprehensive review of the syndromes and disorders associated with NTDs, including Pallister-Hall syndrome, Walker-Warburg syndrome and Fukuyama congenital muscular dystrophy, MURCS association, Roberts ... | 18,935,987 |
Trial of labor after one cesarean: role of the order and number of prior vaginal births on the risk of emergency cesarean delivery and neonatal admission. | To evaluate the influences of mode of immediate preceding delivery and number of prior vaginal births on the risk of repeat cesarean and neonatal admission at attempted vaginal birth after cesarean. We performed a retrospective study of the risk factors for emergency repeat cesarean delivery and neonatal admission in a... | 18,935,994 |
Successful treatment of twin-twin transfusion syndrome by occlusion of placental vessel anastomoses using enbucrilate. | Twin-twin transfusion syndrome is a serious obstetric complication unique to monochorionic twin gestations. Occlusion of vessel anastomoses is recommended to improve the perinatal outcome. A 36-year-old, gravida 1, woman had a monochorionic twin pregnancy which was found to be affected by twin-twin transfusion syndrome... | 18,935,999 |
CT protocol for acute stroke: tips and tricks for general radiologists. | Acute stroke services have been installed in most hospitals in the industrialized world, and dealing with hyperacute stroke has become one of the most frequently performed tasks of the on-call radiologist. Imaging plays a key role in current guidelines for thrombolysis, and knowledge of classic early ischemic signs or ... | 18,936,029 |
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. | Post-translational hydroxylation has been considered an unusual modification on intracellular proteins. However, following the recognition that oxygen-sensitive prolyl and asparaginyl hydroxylation are central to the regulation of the transcription factor hypoxia-inducible factor (HIF), interest has centered on the pos... | 18,936,059 |
Evidence for an inhibitory role of bone morphogenetic protein(s) in the follicular-luteal transition in cattle. | Bone morphogenetic proteins (BMPs) and their receptors are expressed in ovarian theca cells (TC) and granulosa cells (GC) and BMPs have been implicated in the regulation of several aspects of follicle development including thecal androgen production and granulosal oestrogen production. Their potential involvement in lu... | 18,936,084 |
Assembly of high order G alpha q-effector complexes with RGS proteins. | Transmembrane signaling through G alpha(q)-coupled receptors is linked to physiological processes such as cardiovascular development and smooth muscle function. Recent crystallographic studies have shown how G alpha(q) interacts with two activation-dependent targets, p63RhoGEF and G protein-coupled receptor kinase 2 (G... | 18,936,096 |
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. | A number of genome-wide association studies have been performed as a robust means of identifying susceptibility loci for Crohn's disease (CD). The loci detected after the completion of the HapMap project are quite concordant among these studies, suggesting that the results are reliable. Recently, the Wellcome Trust Cas... | 18,936,107 |
Simultaneous estimation of null alleles and inbreeding coefficients. | Although microsatellites are a very efficient tool for many population genetics applications, they may occasionally produce "null" alleles, which, when present in high proportion, may affect estimates of key parameters such as inbreeding and relatedness coefficients or measures of genetic differentiation. In order to a... | 18,936,113 |
Endoscopic anatomical nerve observation and minimally invasive management of cubital tunnel syndrome. | Experience with the use of the Universal Subcutaneous Endoscope (USE) system in surgical treatment of cubital tunnel syndrome in 35 patients is reported. Patients included in the study had pre- and postoperative clinical and electrophysiological data, and had undergone a minimum follow-up period of 13 months. Mean pati... | 18,936,128 |
The clinical significance of malunion of fractures of the neck and shaft of the little finger metacarpal. | The outcomes of 218 little finger metacarpal shaft and neck fractures that had been treated non-operatively, with no attempt at fracture reduction, were compared with those of 44 that had been treated operatively with fracture reduction and fixation (plates or K-wires). Outcome measures included the grip strength of th... | 18,936,129 |
Scaphotrapezial arthritis after a carpometacarpal fusion in a patient with Marfan's Syndrome: case report. | We report a case of scaphotrapezial arthritis that developed in a patient with Marfan's syndrome many years after a carpometacarpal fusion, which placed the thumb metacarpal in adduction. This problem was effectively treated with an abduction/opposition osteotomy, which both increased the patient's first web space and ... | 18,936,131 |
Human ocular-derived virus-specific CD4+ T cells control varicella zoster virus replication in human retinal pigment epithelial cells. | Varicella zoster virus (VZV)-induced retinitis is characterized by the presence of virus-infected cells in the retinal layer and the ocular infiltration of VZV-specific T cells. Herein, the susceptibility of human retinal pigment epithelial (RPE) cells to VZV infection and the ability of virus-specific CD4(+) T cells t... | 18,936,136 |
Anchorage-independent growth of pocket protein-deficient murine fibroblasts requires bypass of G2 arrest and can be accomplished by expression of TBX2. | Mouse embryonic fibroblasts (MEFs) deficient for pocket proteins (i.e., pRB/p107-, pRB/p130-, or pRB/p107/p130-deficient MEFs) have lost proper G(1) control and are refractory to Ras(V12)-induced senescence. However, pocket protein-deficient MEFs expressing Ras(V12) were unable to exhibit anchorage-independent growth o... | 18,936,168 |
The cytoplasmic domain of anthrax toxin receptor 1 affects binding of the protective antigen. | The protective antigen (PA) component of anthrax toxin binds the I domain of the receptor ANTXR1. Integrin I domains convert between open and closed conformations that bind ligand with high and low affinities, respectively; this process is regulated by signaling from the cytoplasmic domains. To assess whether intracell... | 18,936,178 |
Methionine-adequate cysteine-free diet does not limit erythrocyte glutathione synthesis in young healthy adult men. | Most methods of determining amino acid (AA) requirements are based on endpoints that determine adequacy for protein synthesis. However, the sulfur AA (SAA) cysteine is believed to be the rate-limiting substrate for synthesis of the most abundant intracellular antioxidant, glutathione (GSH). Our objectives were to deter... | 18,936,215 |
Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L.). | Atlantic salmon (Salmo salar L.) can produce (n-3) long-chain (LC)-PUFA when fed biosynthetic precursors. This has potential for developing sustainable aquafeeds. Echium oil (EO) is rich in stearidonic acid [SDA; 18:4(n-3)] and bypasses the initial Delta6 desaturase (FAD6) step in the (n-3) LC-PUFA biosynthetic pathway... | 18,936,216 |
Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. | Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation... | 18,936,236 |
Protein localization by actin treadmilling and molecular motors regulates stereocilia shape and treadmilling rate. | We present a physical model that describes the active localization of actin-regulating proteins inside stereocilia during steady-state conditions. The mechanism of localization is through the interplay of free diffusion and directed motion, which is driven by coupling to the treadmilling actin filaments and to myosin m... | 18,936,243 |
Identification of specific histidines as pH sensors in flavivirus membrane fusion. | The flavivirus membrane fusion machinery, like that of many other enveloped viruses, is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. It has been hypothesized that conserved histidines in the class II fusion protein E of these viruses function as molecular switches and, by... | 18,936,253 |
What Australians know and believe about bird flu: results of a population telephone survey. | The avian influenza A (A/H5N1) virus has attracted the attention of governments and health organizations throughout the world because of its pandemic potential. Despite the emerging nature of A/H5N1, there is limited research on public knowledge and perceptions of this disease. This study is based on a computer-assiste... | 18,936,262 |
The characteristics of the outdoor school environment associated with physical activity. | The school is an important setting for physical activity. The purpose of the present study was to examine the association between physical environmental characteristics and participation in daily physical activity during school breaks. Data from 130 schools and 16 471 students (Grades 4-10) in Norway were obtained in 2... | 18,936,270 |
Reciprocal thalamocortical connectivity of the medial pulvinar: a depth stimulation and evoked potential study in human brain. | The thalamic medial pulvinar nucleus (PuM) is fully developed only in primates and reaches its greatest extent in humans. To assess the reciprocal functional connectivity between PuM and cortex, we studied intracerebral-evoked responses obtained after PuM and cortical electrical stimulation in 7 epileptic patients unde... | 18,936,272 |
Bicycle-related injuries among children and adolescents in the United States. | The objective of this study is to describe the epidemiology of bicycle-related injuries among children and adolescents 18 years and younger on a national level. This is a retrospective analysis of data from the National Electronic Injury Surveillance System of the US Consumer Product Safety Commission for patients 18 y... | 18,936,286 |
Meningitis due to hematogenous dissemination of community-associated methicillin-resistant Staphylococcus aureus (MRSA) in a patient with AIDS. | Meningitis due to methicillin-resistant Staphylococcus aureus is a rare clinical presentation but has been well documented in postneurosurgical patients. To our knowledge, no case of methicillin-resistant Staphylococcus aureus meningitis has been previously reported in a nonneurosurgical patient with AIDS. In this case... | 18,936,290 |
Frequency and histopathologic basis of hepatic surface nodularity in patients with fulminant hepatic failure. | To determine the frequency and histopathologic basis of hepatic surface nodularity at imaging in patients with fulminant hepatic failure. The committee on human research approved this HIPAA-compliant study and waived written informed consent. Thirty-five consecutive patients [24 female [mean age, 38 years +/- 19 (stand... | 18,936,312 |
Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. | Inducible nitric oxide synthase (iNOS) is an obligatory mediator of the late phase of ischemic preconditioning, but the mechanisms of its cardioprotective actions are unknown. In addition, it remains unclear whether sustained elevation of iNOS in myocytes provides chronic protection against ischemia/reperfusion injury.... | 18,936,326 |
Deep dissecting hematoma: an emerging severe complication of dermatoporosis. | To outline the characteristics of deep dissecting hematoma (DDH). Retrospective medical record review. Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland. Thirty-four patients with DDH. Deep incision or surgical debridement was performed in all the patients. Direct closure of the incision was... | 18,936,393 |
Use of evidence-based therapies after discharge among elderly patients with acute myocardial infarction. | Postdischarge use of evidence-based drug therapies has been proposed as a measure of quality of care for myocardial infarction patients. We examined trends in the use of evidence-based drug therapies after discharge among elderly patients with myocardial infarction. We performed a cross-sectional study in a retrospecti... | 18,936,454 |
Factors associated with the use of evidence-based therapies after discharge among elderly patients with myocardial infarction. | In an accompanying article, we report moderate between-hospital variation in the postdischarge use of beta-blockers, angiotensin-modifying drugs and statins by elderly patients who had been admitted to hospital with acute myocardial infarction. Our objective was to identify the characteristics of patients, physicians, ... | 18,936,455 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.