title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer. | We showed previously that in early-stage non-small-cell lung cancer (NSCLC), serum vitamin D levels and VDR polymorphisms were associated with survival. We hypothesized that vitamin D levels and VDR polymorphisms may also affect survival among patients with advanced NSCLC. We evaluated the relationship between circulat... | 18,936,471 |
Cost-effectiveness of nurse-led disease management for heart failure in an ethnically diverse urban community. | Randomized, controlled trials have shown that nurse-led disease management for patients with heart failure can reduce hospitalizations. Less is known about the cost-effectiveness of these interventions. To estimate the cost-effectiveness of a nurse-led disease management intervention over 12 months, implemented in a ra... | 18,936,502 |
Primary care interventions to promote breastfeeding: U.S. Preventive Services Task Force recommendation statement. | Update of a 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on counseling to promote breastfeeding. The USPSTF evaluated the results of a systematic review, conducted by the Tufts-New England Medical Center Evidence-based Practice Center, of literature published since January 2007 on primary care-initi... | 18,936,503 |
A rare case of posterior urethral valve and pleural effusion in Down syndrome with successful intrauterine shunt. | Posterior urethral valve or pleural effusion accompanied with Down syndrome have been described previously; however, there is no reported case of posterior urethral valve and pleural effusion with Down syndrome. A 45-year-old multigravida woman was transferred due to bilateral fetal hydrothorax, polyhydramnios, and thr... | 18,936,544 |
Elective use of aortic balloon occlusion in cesarean hysterectomy for placenta previa percreta. | Only few reports are available on the use of aortic balloon catheter for cesarean hysterectomy in placenta previa percreta. A 32-year-old woman with placenta previa percreta underwent cesarean hysterectomy at 34 weeks of gestation. Before starting the surgery, an aortic occlusion balloon catheter (30 mm balloon, 5 Fr) ... | 18,936,549 |
Dialysis and the elderly: an underestimated problem. | In developed countries, the incidence of end-stage renal failure is constantly increasing, and uremia will soon be a disease typically found in mature and elderly adults. Almost invariably, the physical condition of the elderly patient with terminal uremia is extremely poor, and therapeutic approach complex. Frequent c... | 18,936,550 |
Are Surgisis biomeshes effective in reducing recurrences after laparoscopic repair of large hiatal hernias? | Prosthetic repair is frequently advocated after repair of large hiatal hernias, and biomeshes have been proposed to help reduce the high recurrence rate. All patients undergoing laparoscopic repair of primary or recurrent large hiatal hernia, and with intraoperative finding of weak diaphragmatic pillars, as judged by t... | 18,936,659 |
Endoscopy-assisted transanal division of an apical pouch bridge after restorative proctocolectomy with a J-shaped ileal pouch. | Restorative proctocolectomy and J-shaped ileal pouch-anal anastomosis have been performed as a standard operation for ulcerative colitis. However, functional problems are sometimes troublesome in the postoperative period. The J pouch was constructed from 2 ileal limbs using the gastrointestinal anastomosis (GIA) staple... | 18,936,672 |
Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biologic and diagnostic implications. | Recent molecular studies have indicated that ductal carcinoma in situ (DCIS)-associated myoepithelial cells (MECs) show differences from MECs in normal breast tissue. Such alterations may influence the progression of DCIS to invasive cancer. The purpose of this study was to investigate further phenotypic alterations in... | 18,936,688 |
Continuous hemofiltration in pigs with hyperdynamic septic shock affects cardiac repolarization. | Sepsis has been defined as the systemic host response to infection with an overwhelming systemic production of both proinflammatory and anti-inflammatory mediators. Continuous hemofiltration has been suggested as possible therapeutic option that may remove the inflammatory mediators. However, hemodialysis and hemofiltr... | 18,936,693 |
Presence of crystalline lens as a protective factor for the late development of open angle glaucoma after vitrectomy. | To evaluate the late development of open angle glaucoma (OAG) after vitrectomy and to compare the rate of postvitrectomy OAG development in phakic and pseudophakic eyes. Retrospective case series of 101 eyes of 101 patients who had vitrectomy for idiopathic epiretinal membrane or idiopathic macular hole with a follow-u... | 18,936,722 |
[Receptors for advanced glycation end products and their physiological and clinical significance]. | The receptor for advanced glycation end products (RAGE) is a multiligand cell-surface protein and belongs to the immunoglobulin superfamily. RAGE is expressed by different cell types, including macrophages, lymphocytes, endothelial, neuronal, and smooth muscle cells. In addition to advanced glycation end products (AGEs... | 18,936,727 |
Regeneration, health status and quality of life after rhG-CSF-stimulated stem cell collection in healthy donors: a cross-sectional study. | Mobilized allogeneic PBPC are increasingly used instead of BM for allogeneic stem cell grafting. Although the short-term safety profile of recombinant human (rh)G-CSF seems acceptable, only minimal data on long-term safety are available. We therefore reviewed data on 171 sibling donors (M/F: 98/73) with respect to side... | 18,936,736 |
Targeting and tinkering with interaction networks. | Biological interaction networks have been in the scientific limelight for nearly a decade. Increasingly, the concept of network biology and its various applications are becoming more commonplace in the community. Recent years have seen networks move from pretty pictures with limited application to solid concepts that a... | 18,936,751 |
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onset. | To date, little is known about why exocrine glands are subject to immune cell infiltrations in Sjögren's syndrome (SjS). Studies with SjS-prone C57BL/6.NOD-Aec1Aec2 mice showed altered glandular homeostasis in the submandibular glands (SMX) at 8 weeks before disease onset and suggested the potential involvement of infl... | 18,936,772 |
Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness. | In the present study we tested the responsiveness of human corneal epithelial cells (HCECs) and corneal fibroblasts to lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand. Purified Pseudomonas aeruginosa LPS was used to stimulate telomerase-immortalized HCECs (HUCL) and stromal fibroblast (THK) cell lines. Ex... | 18,936,773 |
Identical-dual-bandpass sampled fiber Bragg grating and its application to ultranarrow filters. | We have theoretically proposed and experimentally demonstrated a new kind of ultranarrow identical-dual-bandpass sampled fiber Bragg gratings (SFBGs) with a pi phase shift technique. The spacing of two bandpasses of the proposed grating can be flexibly adjusted by changing the sampled period, and any desired spacing ca... | 18,936,812 |
Linear basis for metallic and iridescent colors. | I have examined the correlation structure in goniochromism by principal-component analysis. Reflectance spectra were collected in synthetic samples that reproduce metallic, nacreous, and iridescent effects under different viewing angles. Although three principal components take into account 99% of the variance, between... | 18,936,813 |
Influence of surface roughness on the polarimetric characteristics of a wire-grid grating polarizer. | The influence of surface roughness on the polarimetric performance of a wire-grid polarizer (WGP) is numerically investigated using rigorous coupled-wave analysis over 100 random surface realizations. Surface roughness is modeled with a Gaussian surface, represented by two independent parameters: surface height deviati... | 18,936,821 |
Alternating current techniques in scanning electrochemical microscopy (AC-SECM). | Alternating current scanning electrochemical microscopy (AC-SECM) is a growing branch within the variety of SECM methods. This review covers publications involving AC-SECM from its beginning to date. The findings of several research groups are thematically structured along with the specific experimental procedures. Thi... | 18,936,824 |
Measurement of elastic properties of prostate cancer cells using AFM. | This communication reports that three prostate cancer cells of differing metastatic potential were discriminated based on their Young's moduli (LNCaP - 287 +/- 52 N m(-2), PC-3 - 1401 +/- 162 N m(-2) and BPH - 2797 +/- 491 N m(-2)) which were determined using AFM and the Hertz model. | 18,936,825 |
Paired emitter detector diode (PEDD)-based photometry--an alternative approach. | According to the developed model based on Shockley equation and the Lambert-Beer law, PEDD-based photometric devices generate a potentiometric analytical signal that is directly proportional to the analyte concentration. | 18,936,826 |
Fabric analysis by ambient mass spectrometry for explosives and drugs. | Desorption electrospray ionization (DESI) is applied to the rapid, in-situ, direct qualitative and quantitative analysis of mixtures of explosives and drugs from a variety of fabrics, including cotton, silk, denim, polyester, rayon, spandex, leather and their blends. The compounds analyzed were explosives: trinitrohexa... | 18,936,830 |
Chemical sensor based on a long-period fibre grating modified by a functionalized polydimethylsiloxane coating. | A chemical sensor based on a coated long-period grating has been prepared and characterized. Designer coatings based on polydimethylsiloxane were prepared by the incorporation of diphenylsiloxane and titanium cross-linker in order to provide enhanced sensitivity for a variety of key environmental pollutants and optimal... | 18,936,831 |
Accurate calibration of mercury vapour measurements. | Almost all measurements of mercury vapour, for example those to determine mass concentration in air, are currently ultimately traceable to the vapour pressure of mercury, usually via a bell-jar calibration apparatus. This allows a saturated concentration of mercury vapour in air to develop in a confined space in equili... | 18,936,841 |
A comparison of ether- and alkyl-derivatized imidazolium-based room-temperature ionic liquids: a molecular dynamics simulation study. | Molecular dynamics simulations of ether-derivatized imidazolium-based room-temperature ionic liquids (EDI-RTILs), [C(5)O(2)mim][TFSI] and [C(5)O(2)mim][BF(4)], have been performed and compared with simulations of alkyl-derivatized analogues (ADI-RTILs). Simulations yield RTIL densities, self-diffusion coefficients and ... | 18,936,854 |
Effects of Macroplastique Implantation System for stress urinary incontinence and urethral hypermobility in women. | A study was carried out to evaluate efficacy of Macroplastique(R) (MPQ) Implantation System (MIS) in women with urodynamic stress urinary incontinence (SUI) and urethral hypermobility after an unsuccessful conservative treatment. This is a prospective randomized controlled trial in women without previous incontinence s... | 18,936,867 |
Is there any evidence to advocate SUI prevention in continent women undergoing prolapse repair? An overview. | Postoperative SUI prevention at the time of prolapse surgery is still a challenging issue. Recent findings suggested that a systematic prophylactic Burch colposuspension could be performed in continent women undergoing a sacral colpopexy. The aim of this paper is to collect relevant literature in order to suggest a man... | 18,936,868 |
Pharmacokinetic analysis of a combined chemoendocrine treatment with paclitaxel and toremifene for metastatic breast cancer. | Multidrug resistance protein could be a target for improving the efficacy of paclitaxel (PXL). Toremifene (TOR) may moderate P-gp-related drug resistance in vitro. Some P-gp moderators may change the pharmacokinetic parameters of PXL in vivo. A pharmacokinetic (PK) study in metastatic breast cancer patients (MBC) was c... | 18,936,884 |
Prevalence of Haemophilus influenzae with resistant genes isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam. | Our study was undertaken to investigate the characteristics of Haemophilus influenzae in young children with acute lower respiratory tract infections in Nha Trang, Vietnam. The study population consisted of 116 children less than 5 years of age admitted to Khanh Hoa General Hospital due to acute lower respiratory tract... | 18,936,887 |
Bacteremia caused by Desulfovibrio fairfieldensis. | Desulfovibrio species are anaerobic gram-negative, pleomorphic bacilli rarely causing infection in humans. In the present report, we describe a case of bacteremia caused by Desulfovibrio fairfieldensis. The patient, for whom biapenem was administered, rapidly improved without any sequelae. As far as we know, this is th... | 18,936,890 |
Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. | To evaluate the accuracy of the soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic test for bacterial infection. Meta-analysis of 13 diagnostic studies. Medline; Embase; Web of Science (from January 1966 to January, update to August 2008); and Cochrane Controlled Clinical Trials Register... | 18,936,908 |
Conjugated steroids: analytical approaches and applications. | An introduction to conjugated steroids and the justification for their analysis is provided covering both environmental and biological samples. Determining conjugated steroids or indeed any organic chemical which is conjugated upon excretion from the body has relevance in diagnostic monitoring, forensic screening and e... | 18,936,918 |
Activity of an atypical Arabidopsis thaliana pectin methylesterase. | An Arabidopsis thaliana pectin methylesterase that was not predicted to contain any signaling sequence was produced in E. coli and purified using a His tag added at its N-terminus. The enzyme demethylesterified Citrus pectin with a Km of 0.86 mg/ml. The enzyme did not require salt for activity and was found to be relat... | 18,936,961 |
Monitoring circulating epithelial tumour cells (CETC) to gauge therapy: in patients with disease progression after trastuzumab persisting CETC can be eliminated by combined lapatinib treatment. | In breast cancers, the gene for the growth factor receptor HER2 can be amplified leading to increased aggressiveness and metastasis formation. The monoclonal antibody trastuzumab prolongs relapse-free survival highly significantly but eventually many patients relapse. In this study, CETC were monitored using the Maintr... | 18,936,973 |
Mapping the interaction sites of Aspergillus nidulans phytochrome FphA with the global regulator VeA and the White Collar protein LreB. | Aspergillus nidulans senses red and blue-light and employs a phytochrome and a Neurospora crassa White Collar (WC) homologous system for light perception and transmits this information into developmental decisions. Under light conditions it undergoes asexual development and in the dark it develops sexually. The phytoch... | 18,936,976 |
Urinary tract infection in preterm infants: the protective role of breastfeeding. | Urinary tract infection (UTI) differs between preterm and older infants and children in terms of prevalence, clinical presentation, causative organism, and rate of underlying renal anomalies. Data on risk factors of UTI in preterm infants are limited. The aim of this study was to characterize UTI both clinically and mi... | 18,936,982 |
Study of structural and electronic origin of ambergris odor of some compounds. | The correlation between structural, stereochemical as well as electronic features and ambergris odor of some tricyclic ethers is established based on quantum chemical calculation method. A definite structural fragment (a "new ambergris triangle") with certain electronic properties determining the origin of the odor is ... | 18,936,989 |
Local friction at a sliding interface between an elastomer and a rigid spherical probe. | This paper reports on spatially resolved measurements of the shear stress distribution at a frictional interface between a flat rubber substrate and a glass lens. Silicone rubber specimens marked close to their surface by a colored pattern have been prepared in order to measure the surface displacement field induced by... | 18,936,992 |
Spike synchronization of chaotic oscillators as a phase transition. | We study how a locally coupled array of spiking chaotic systems synchronizes to an external driving in a short time. Synchronization means spike separation at adjacent sites much shorter than the average inter-spike interval; a local lack of synchronization is called a defect. The system displays sudden spontaneous def... | 18,936,995 |
"Wave" as defined by wave intensity analysis. | The propagation of waves in the arteries is generally described using Fourier analysis in terms of periodic wavetrains formed by the superposition of a mean value and sinusoidal waves at the fundamental frequency (defined by the heart rate) and its harmonics. There is, however, an alternative way to describe waves in t... | 18,937,000 |
The neuroprotective role of L-cysteine towards the effects of short-term exposure to lanthanum on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase. | Lanthanum (La) is a rare earth element that is widely used for industrial, medical and agricultural purposes. Its neurotoxic effects are linked to its physical and chemical properties and its interaction with certain trace elements and membrane-bound enzymes. The aim of this study was to investigate the effects of shor... | 18,937,033 |
Quality control of photosystem II: impact of light and heat stresses. | Photosystem II is vulnerable to various abiotic stresses such as strong visible light and heat. Under both stresses, the damage seems to be triggered by reactive oxygen species, and the most critical damage occurs in the reaction center-binding D1 protein. Recent progress has been made in identifying the protease invol... | 18,937,045 |
How parents search, interpret, and evaluate genetic information obtained from the internet. | This study describes how parents of a child referred for genetic services searched the Internet for information, summarizes how they interpreted and evaluated the information they obtained, and identifies barriers that they encountered. Audio-taped interviews were conducted with 100 ethnically diverse families referred... | 18,937,062 |
Evaluation of the association between retinal binding protein 4 polymorphisms and type 2 diabetes in Chinese by DHPLC. | Serum retinal binding protein 4 (RBP4) was recently described as a new liver- and adipocyte-derived signal that may contribute to Type 2 diabetes mellitus (T2DM) and insulin resistance. The aim of this study was to test whether the RBP4 gene could be used as a genetic marker to predict the development of T2DM amongst t... | 18,937,078 |
The predictive qualities of operator characteristics for process control performance: the influence of personality and cognitive variables. | This article examines the relationship between operator characteristics and process control performance. Thirty-nine trainee operators participated in a 4-h training session of a simulated process control task and a testing session in which various system faults had to be managed. Cognitive ability, cognitive flexibili... | 18,937,088 |
Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats. | Renin-angiotensin system inhibitors are reported to be beneficial in delaying the onset of diabetes mellitus. Since islet blood hyperperfusion during hyperglycaemia may be detrimental to endothelium in pancreatic islets and eventually lead to beta-cell dysfunction, we studied acute and chronic effects of angiotensin II... | 18,937,099 |
Flow-mediated vasodilatation: variation and interrelationships with plasma lipids and lipoproteins. | Endothelial dysfunction is a critical, prerequisite step in atherosclerosis, and may be evaluated by flow-mediated vasodilatation (FMD). The objective of this study was to examine interrelationships between FMD and plasma lipids and lipoproteins, and to determine the between-operator and within-subject variability asso... | 18,937,098 |
The effects of interferon beta-1a on proton MR spectroscopic imaging in patients with multiple sclerosis, a controlled study, preliminary results. | To evaluate the effects of interferon beta-1a(INFbeta-1a) on brain metabolites in patients with multiple sclerosis (MS), we performed Magnetic Resonance Spectroscopy Imaging (MRSI) on five patients treated with INFbeta-1a (Rebif 44 microg), and on five untreated patients. Six healthy volunteers were used as controls. P... | 18,937,112 |
Endogenous glucocorticoids participate in retinal degeneration during continuous illumination. | Continuous illumination (CI) induces an oxidative stress of the retina which is involved in light-induced retinal degeneration (LIRD). As the increase of glucocorticoids (GC) could also collaborate in the damage, adrenalectomized (ADX) and sham-operated rats (control, CTL) were submitted to CI, and their eyes were stud... | 18,937,116 |
Equipment, exposure, emission review--specification of process equipment for worker exposure control. | Worker exposure to chemical agents may occur from equipment leaks in closed processes and from open system activities and maintenance (e.g., sampling, tank gauging, line breaking, equipment flushing, and drainage). To prevent worker overexposure to chemical agents, an Equipment, Exposure, Emission Review (EEER) was dev... | 18,937,122 |
Use of combined oral contraceptives alters metabolic determinants and genetic regulation of C-reactive protein. The Cardiovascular Risk in Young Finns Study. | Use of combined oral contraceptives (COCs) is known to increase concentrations of C-reactive protein (CRP), an important predictor of cardiovascular disease. The inflammatory nature of the disease is well acknowledged. The aim of this study was to find out whether the metabolic, lifestyle and genetic determinants of CR... | 18,937,150 |
Anaemia following initiation of androgen deprivation therapy for metastatic prostate cancer: a retrospective chart review. | Haemoglobin levels often decline into the anaemic range with androgen deprivation therapy (ADT). We conducted a chart review of patients receiving ADT for metastatic prostate cancer to assess anaemia-related symptoms. 135 stage IV prostate cancer cases were reviewed for treatment type; haemoglobin values before and aft... | 18,937,151 |
[Cerebral and spinal MRI examination in patients with clinically isolated syndrome and definite multiple sclerosis]. | Magnetic resonance imaging (MRI) has become a valuable tool for diagnosing and monitoring multiple sclerosis (MS). The high sensitivity for the detection of hyperintense lesions in T 2-weighted scans contributes substantially to diagnosis. The initial lesion number or lesion volume stands for an increased probability o... | 18,937,154 |
Perspective on recent developments on sulfur-containing agents and hydrogen sulfide signaling. | The last couple of years have witnessed the coming together of several initially unconnected lines of investigation which now link natural sulfur products to hydrogen sulfide release and wide ranging cardiovascular protection. It has become apparent that sulfur compounds contained within garlic, onions, mushrooms and v... | 18,937,169 |
Two cases of lymphoepithelial cyst of the pancreas: first - a cyst coexisting with a primary gastric lymphoma, second - incidentally found pancreatic cyst. | The aim of this report is to describe two cases of lymphoepithelial cysts (LEC) of the pancreas: 1. LEC coexisting with primary gastric lymphoma, 2. an incidental finding of LEC during imaging examination. 1. A 47-year old man complaining of epigastric pain showed a 2 x 1.5 cm cyst of the pancreatic head on computed to... | 18,937,188 |
Resolution of refractory ascites after transcoronary septal ablation for hypertrophic obstructive cardiomyopathy in a cirrhotic patient. | This report presents the first case of complete resolution of ascites after transcoronary ablation of septal hypertrophy (TASH) in a cirrhotic patient with concomitant hypertrophic cardiomyopathy (HOCM). A 52-years-old woman with decompensated alcoholic liver cirrhosis was referred to our department for placement of a ... | 18,937,189 |
[Endothelial adrenal cyst mimicking cystic echinococcosis in a Turkish woman]. | Cystic liver lesions include hepatic echinococcosis as an important differential diagnosis, especially in patients from endemic countries. Serology might be false negative in a relevant percentage of the patients. Thus, modern clinical imaging techniques are the most important non-invasive means for making or excluding... | 18,937,190 |
Science, marketing and wishful thinking in quantitative proteomics. | In a recent editorial (J. Proteome Res. 2007, 6, 1633) and elsewhere questions have been raised regarding the lack of attention paid to good analytical practice with respect to the reporting of quantitative results in proteomics. Using those comments as a starting point, several issues are discussed that relate to the ... | 18,937,255 |
mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours. | The aim of this study was to identify genes involved in the development of borderline and malignant phyllodes tumours of the breast (PTs). Expression profiling of 23 PTs (12 benign, 11 borderline/malignant) was performed using Affymetrix U133A GeneChips. mRNA expression in the borderline/malignant PTs was compared to t... | 18,937,276 |
Simultaneous quantification of a non-nucleoside reverse transcriptase inhibitor efavirenz, a nucleoside reverse transcriptase inhibitor emtricitabine and a nucleotide reverse transcriptase inhibitor tenofovir in plasma by liquid chromatography positive ion electrospray tandem mass spectrometry. | A high-performance liquid chromatography/positive ion electrospray tandem mass spectrometry method for the simultaneous quantification of efavirenz, emtricitabine and tenofovir was developed and validated with 100 microL human plasma. Following solid-phase extraction, the analytes were separated using a gradient mobile... | 18,937,306 |
Outcome of high-risk stage 3 neuroblastoma with myeloablative therapy and 13-cis-retinoic acid: a report from the Children's Oncology Group. | The components of therapy required for patients with INSS Stage 3 neuroblastoma and high-risk features remain controversial. A retrospective cohort design was used to determine if intensive chemoradiotherapy with purged autologous bone marrow rescue (ABMT) and/or 13-cis-retinoic acid (13-cis-RA) improved outcome for pa... | 18,937,318 |
Symmetry variation in the heart-descending artery system of the parthenogenetic marbled crayfish. | The internal anatomy of freshwater crayfish is strictly bilaterally symmetric, with the conspicuous exception of the vertically oriented descending artery (sternal artery), which originates from the heart and terminates in the subneural artery. Serial sectioning of 133 juveniles of the parthenogenetic marbled crayfish ... | 18,937,329 |
Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. | The primordial follicles present in neonatal ovary represent the fecundity of a female throughout her reproductive life. Germ cell meiosis and apoptosis are two important events during primordial folliculogenesis. In this study, through focusing on the cytochrome P450 lanosterol 14 alphademethylase (CYP51) and its lano... | 18,937,335 |
Inhibition of methylation and changes in gene expression in relation to neural tube defects. | An impaired DNA methylation has been suggested to underlie the complex etiology of neural tube defects (NTDs). Previously, we have demonstrated that inhibition of methylation by periodate oxidized adenosine (Adox) results in a widening of the anterior neuropore (ANP) in our in vitro chick embryo model. Since DNA methyl... | 18,937,356 |
Design of small-molecule peptidic and nonpeptidic Smac mimetics. | Smac/DIABLO is a protein released from mitochondria into the cytosol in response to apoptotic stimuli. Smac promotes apoptosis at least in part through antagonizing inhibitor of apoptosis proteins (IAPs), including XIAP, cIAP-1, and cIAP-2. Smac interacts with these IAPs via its N-terminal AVPI binding motif. There has... | 18,937,395 |
pH-sensitivity of the E3/K3 heterodimeric coiled coil. | This manuscript reports on the self-assembly properties of two complementary peptide sequences, E3 and K3, which are derived from the known IAAL E3/K3 heterodimeric coiled coil motif. Circular dichroism spectroscopy, analytical ultracentrifugation, and fluorescence resonance energy transfer experiments indicated that a... | 18,937,405 |
Synthesis of alpha-keto-imides via oxidation of ynamides. | A de novo preparation of alpha-keto-imides via ynamide oxidation is described. With a number of alkyne oxidation conditions screened, a highly efficient RuO2-NaIO4 mediated oxidation and a DMDO oxidation have been identified to tolerate a wide range of ynamide types. In addition to accessing a wide variety of alpha-ket... | 18,937,407 |
Efficient iron/copper cocatalyzed alkynylation of aryl iodides with terminal alkynes. | We developed a highly efficient and practical protocol for the coupling of terminal alkynes with aryl iodides that is catalyzed by inexpensive and environmentally benign Fe/Cu. A broad spectrum of substrates can participate in the process effectively to produce desired products in good yields. The versatility, generali... | 18,937,417 |
One-step label-free optical genosensing system for sequence-specific DNA related to the human immunodeficiency virus based on the measurements of light scattering signals of gold nanorods. | A one-step label-free optical genosensing method has been developed in this contribution by taking short DNA target with its sequence related to the human immunodeficiency virus type 1 (HIV-1) as an example. By employing anisotropic nonspherical and positively charged gold nanorods (Au-NRs) as the recognition platform,... | 18,937,420 |
Quantitation of steroid hormones in thin fresh frozen tissue sections. | As analytical technologies in proteomics and metabolomics continue to mature, there is an increasing need to apply these to clinically relevant biologic samples. In this study, a liquid chromatography-tandem mass spectrometry method that utilizes selected reaction monitoring was used to measure the absolute quantity of... | 18,937,426 |
Evaluation of flexible linear tricationic salts as gas-phase ion-pairing reagents for the detection of divalent anions in positive mode ESI-MS. | Anion analysis is of great importance to many scientific areas of interest. Problems with negative mode ESI-MS prevent researchers from achieving sensitive detection for anions. Recently, we have shown that cationic reagents can be paired with anions, such that detection can be done in the positive mode, allowing for l... | 18,937,427 |
Interaction model based on local protein substructures generalizes to the entire structural enzyme-ligand space. | Chemogenomics is a new strategy in in silico drug discovery, where the ultimate goal is to understand molecular recognition for all molecules interacting with all proteins in the proteome. To study such cross interactions, methods that can generalize over proteins that vary greatly in sequence, structure, and function ... | 18,937,438 |
Chiral anion-mediated asymmetric ring opening of meso-aziridinium and episulfonium ions. | Reactions proceeding through cationic intermediates that lack a Lewis or Brønsted basic site present a challenge for traditional asymmetric catalysis based on chiral metals or organocatalysts. We present an enantioselective ring opening of tetrasubstituted meso-aziridinium ions with alcohol nucleophiles proceeding thro... | 18,937,464 |
Structural analysis of the Mn(IV)/Fe(III) cofactor of Chlamydia trachomatis ribonucleotide reductase by extended X-ray absorption fine structure spectroscopy and density functional theory calculations. | The class Ic ribonucleotide reductase from Chlamydia trachomatis ( Ct) uses a stable Mn(IV)/Fe(III) cofactor to initiate nucleotide reduction by a free-radical mechanism. Extended X-ray absorption fine structure (EXAFS) spectroscopy and density functional theory (DFT) calculations are used to postulate a structure for ... | 18,937,466 |
Binding of flavor compounds and whey protein isolate as affected by heat and high pressure treatments. | The interactions of whey protein isolate (WPI) and flavor compounds (2-nonanone, 1-nonanal, and trans-2-nonenal) were investigated, and the influence of flavor compound structure and heat and high pressure denaturation on the interactions were determined by using headspace solid-phase microextraction (SPME) and gas chr... | 18,937,489 |
Phytochemical diversity in tubers of potato cultivars and landraces using a GC-MS metabolomics approach. | Phytochemical diversity with respect to a range of polar (including amino acids, organic acids, sugars, and sugar alcohols) and nonpolar (including fatty acids, alkanols, and sterols) metabolites was examined within tubers from a total of 29 genetically diverse potato cultivars and Chilean landraces using a metabolomic... | 18,937,493 |
Location of subunit d in the peripheral stalk of the ATP synthase from Saccharomyces cerevisiae. | ATP synthase from Saccharomyces cerevisiae is an approximately 600 kDa membrane protein complex. The enzyme couples the proton motive force across the mitochondrial inner membrane to the synthesis of ATP from ADP and inorganic phosphate. The peripheral stalk subcomplex acts as a stator, preventing the rotation of the s... | 18,937,496 |
Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents. | Rhomboid, a polytopic membrane serine protease, represents a unique class of proteases that cleave substrates within the transmembrane domain. Elucidating the mechanism of this extraordinary catalysis comes with inherent challenges related to membrane-associated peptide hydrolysis. Here we established a system that all... | 18,937,501 |
The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. | DNA polymerase beta plays a key role in base excision repair. We have previously shown that the hydrophobic hinge region of polymerase beta, which is distant from its active site, plays a critical role in the fidelity of DNA synthesis by this enzyme. The I260Q hinge variant of polymerase beta misincorporates nucleotide... | 18,937,502 |
Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation. | Among the phospholipases A 2 (PLA 2s) are the group VI Ca (2+)-independent PLA 2s (iPLA 2s), and expression of multiple transcripts of iPLA 2 in skeletal muscle has been reported. In the present study, phospholipase activity and sequential ATP and calmodulin affinity column chromatography analyses reveal that skeletal ... | 18,937,505 |
Laser fabrication and spectroscopy of organic nanoparticles. | In working with nanoparticles, researchers still face two fundamental challenges: how to fabricate the nanoparticles with controlled size and shape and how to characterize them. In this Account, we describe recent advances in laser technology both for the synthesis of organic nanoparticles and for their analysis by sin... | 18,937,507 |
The importance of sensory-motor control in providing core stability: implications for measurement and training. | Although the hip musculature is found to be very important in connecting the core to the lower extremities and in transferring forces from and to the core, it is proposed to leave the hip musculature out of consideration when talking about the concept of core stability. A low level of co-contraction of the trunk muscle... | 18,937,521 |
Mucocele: a human model for lymphangiogenesis. | The mechanism of lymphangiogenesis is poorly understood, and controversy exists whether it is part of the inflammatory response to tissue injury. Utilizing markers specific to lymphatics, we aimed to study if lymphangiogenesis plays a role in the tissue response of mucoceles. Twenty-three extravasated mucoceles were se... | 18,937,525 |
Enantioselectivity in the immunotoxicity of the insecticide acetofenate in an in vitro model. | Chiral pesticides with an asymmetrical center in their molecular structures possess enantioselectivity, not only in their pesticidal activities toward targeted organisms but also in toxicities to nontargeted organisms. Despite the fact that chiral pesticides deserve particular attention because of their ubiquitous pres... | 18,937,538 |
Rigid interferon-alpha subtype responses of human plasmacytoid dendritic cells. | The large family of human type I interferon (IFN) includes 13 distinct subtypes of IFN-alpha, all utilizing a single type I IFN receptor. Many viruses have created evasion strategies to disable this cytokine family, highlighting their importance in antiviral defense. It is unclear what advantage the presence of so many... | 18,937,549 |
Multistate outbreak of Pseudomonas fluorescens bloodstream infection after exposure to contaminated heparinized saline flush prepared by a compounding pharmacy. | Pharmaceutical compounding, the manipulation of ingredients to create a customized medication, is a widespread practice. In January 2005, the Centers for Disease Control and Prevention was notified of 4 cases of Pseudomonas fluorescens bacteremia that were traced to contaminated heparinized saline intravenous flush syr... | 18,937,575 |
Twenty years of single center experience in ESWL 1987-2007: an evaluation of 3079 patients. | Since 1987 we have consecutively operated five different Dornier lithotriptors in the management of lithiasis at all levels of the urinary tract. At the time of usage of each machine we periodically evaluated the treatment results in order to eventually adapt treatment strategies to improve results. None of these evalu... | 18,937,585 |
Extracorporeal shock wave lithotripsy in an elderly population: how to prevent complications and make the treatment safe and effective. | The aim of our study is to consider the feasibility and the results of shock wave lithotripsy (SWL) in an elderly cohort of patients, considering different diseases and concomitant morbidity. From January 2003 up to July 2006, a total of 1100 SWL treatments were performed in our Stone Centre with Dornier Lithotripter S... | 18,937,586 |
Long-term outcome of laparoscopic retroperitoneal nephropexy. | Laparoscopy has been reported recently as a minimally invasive approach for nephropexy. We evaluated our long-term outcomes and quality of life (QoL) after laparoscopic retroperitoneal nephropexy (LRNP). Forty-eight patients with symptomatic nephroptosis with a mean age of 36.2 years underwent LRNP between February 199... | 18,937,591 |
Diagnostic yield of renal biopsy immediately prior to laparoscopic radiofrequency ablation: a multicenter study. | Ablative therapy is increasing for the management of small renal masses. Laparoscopic as well as percutaneous cryotherapy and radiofrequency ablation (RFA) have been utilized. Herein we review our experience with renal biopsy immediately prior to laparoscopic RFA. A prospectively collected database containing all patie... | 18,937,593 |
Effect of rimonabant, micronised fenofibrate and their combination on cardiometabolic risk factors in overweight/obese patients: a pilot study. | To assess the effect of rimonabant, micronised fenofibrate and their combination on anthropometric and metabolic parameters in overweight/obese patients with dyslipidaemia. All patients (n = 30) received a hypocaloric diet ( approximately 600 kcal/day deficit) and were randomly allocated to receive open-label rimonaban... | 18,937,609 |
Antibiotic management of sepsis: current concepts. | The development of guidelines for sepsis management has improved disease survival and reduced treatment costs. Adequate antibiotic therapy is the cornerstone of sepsis treatment. Specific rules should be established in every institution according to its profiles. To review the current knowledge about the best drugs to ... | 18,937,614 |
Niacin: a lipid polypill? | Niacin is one of the oldest yet also most diverse lipid lowering agents. As it not only lowers low-density-lipoprotein (LDL) cholesterol, triglycerides (TG) and lipoprotein(a) [Lp(a)] but also increases high-density-lipoprotein (HDL) cholesterol, it is useful for treating a wide variety of lipid disorders including mix... | 18,937,622 |
Premature atherosclerotic cardiovascular disease and systemic lupus erythematosus from bedside to bench. | Cardiovascular morbidity and mortality in SLE is increased in patient with established disease, and SLE itself has been determined to be an independent risk factor for cardiovascular events. Autopsy studies have demonstrated that the coronary vessels of SLE patients have atherosclerotic plaque, and most cardiovascular ... | 18,937,629 |
Emerging therapeutics for rheumatoid arthritis. | Therapeutics options for rheumatoid arthritis (RA) have increased tremendously in the past decade with the introduction of biological agents in 1999. Several different cellular and cytokine targets have been identified, with specific inhibitors now approved to treat RA, including the tumor necrosis factor (TNF) antagon... | 18,937,634 |
Update on the management of hyperuricemia and gout. | Gout is the most common inflammatory arthritis in the United States, with more than three million sufferers. Management of gout has changed relatively little in the past 50 years, despite the fact that many gout patients have contraindications to one or more currently available gout therapies. However, recent insights ... | 18,937,638 |
Osteoarthritis: a tale of three tissues. | While research in osteoarthritis has focused on the events that lead to the destruction of articular cartilage, recent evidence suggests that two other components of the joints-bone and synovium-also play key roles in pathogenesis. All three tissues undergo alterations in concert at the structural levels in response to... | 18,937,640 |
Advanced imaging in osteoarthritis. | Historically plain radiography has been the primary investigative tool by which structure in osteoarthritis is measured. Magnetic resonance imaging (MRI) is widely used in medical diagnosis for its various advantageous features, such as high-resolution capability, the ability to produce an arbitrary anatomic cross-sect... | 18,937,641 |
Tissue estimation of protein gene product 9.5 (PGP 9.5) expression and apoptosis in vitiligo. | Vitiligo is probably the end result of different interacting processes. To determine the possible roles of neural and apoptotic mechanisms in the pathogenesis of vitiligo. Fifty-six biopsies from 28 patients with generalized vitiligo (28 from depigmented lesional areas and 28 from clinically nondepigmented skin at the ... | 18,937,653 |
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