title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Bulbocapnine's ability to antagonize the adrenergic inhibitory action of dopamine and analogs. | Dopamine in the presence of cocaine, 5,6-dihydroxy-2-dimethylaminotetralin (M-7), apomorphine and N,N-dimethyldopamine produced dose dependent inhibition on the heart rate increase due to stimulation of the right cardioaccelerator postganglionic nerves. Inhibitory actions of these compounds were antagonized by bulbocap... | 240,727 | [
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Apomorphine-like effect of an aminotetralin on the linguomandibular reflex of the cat. | Low doses of 5,6-dihydroxy-2-dimethylaminotetralin (M-7) produced inhibition of the linguomandibular reflex in the cat. This inhibition was similar to that produced by apomorphine and was blocked by haloperidol, bulbocapnine or chlorpromazine. M-7 also had a brief but marked hypertensive effect. Gradual bradycardia als... | 240,731 | [
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Effect of boseimycin on some enzyme systems of Bacillus subtilis. | The effect of boseimycin on the in vitro activity and in vivo synthesis of alkaline phosphatase, aconitase and lactate, isocitrate, glutamate and alanine dehydrogenases was studied in Bacillus subtilis. At a subinhibitory concentration, synthesis of glutamate dehydrogenase was stimulated but alkaline phosphatase, lacta... | 240,761 | [
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Hypothermia and rewarming induced by surface and He-O2 inhalate temperature control. | Hypothermia and rewarming were induced by a combination of temperature-controlled surface and inhalate methods in rabbits. To facilitate respiratory heat exchange, inhalate-respiratory tract temperature and humidity gradients and thermal conductivity were increased. In addition, the upper respiratory tract was bypassed... | 240,798 | [
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Awake baboon's ventilatory response to venous and inhaled CO2 loading. | Steady-state ventilatory responses to CO2 in trained awake baboons were studied to determine the response to a venous CO2 load. CO2 was loaded either directly into the venous blood through an arteriovenous shunt or by addition to the inhaled air. The two modes of loading were adjusted to produce the same increase in mi... | 240,801 | [
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Mucociliary tracheal transport rates in man. | A new method for measuring mucociliary tracheal transport rates (MTTR's) is described. An aqueous aerosol containing albumin microspheres labeled with 99mTc was inhaled in such a manner that it was deposited in local concentrations in the large airways. These boli of microspheres were transported up the trachea and the... | 240,802 | [
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Inhibition of amino acid transport by ammonium ion in Saccharomyces cerevisiae. | The rate of transport of L-amino acids by Saccharomyces cerevisiae epsilon 1278b increased with time in response to nitrogen starvation. This increase could be prevented by the addition of ammonium sulfate or cycloheximide. A slow time-dependent loss of transport activity was observed when ammonium sulfate (or ammonium... | 240,806 | [
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Self-association of lysozyme. Thermochemical measurements: effect of chemical modification of Trp-62, Trp-108, and Glu-35. | Heats of dilution and of saccharide binding for hen egg white lysozyme have been measured at 30 degrees, 0.1 ionic strength, and pH 7 over the range 3 to 95 mg of protein/ml. The concentration dependence of the apparent relative molar enthalpy of lysozyme derived from these results gives the thermodynamic parameters fo... | 240,855 | [
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Neglect and abuse of children: historical aspects, identification, and management. | The dentist's role primarily involves awareness of the problem of maltreatment, a method of approach to identify and report suspected cases, the documentation of the injuries or neglect which have been observed, and follow-up of any orofacial injuries. Orofacial trauma is present in up to one half of the reported cases... | 240,877 | [
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Correlation between mosquito repellent protection time and insensible water loss from the skin. | Insensible water loss and mosquito repellent protection time have been found to be relatively characteristic of any given individual. In a population having a biologic distribution of repellent protection period against mosquitoes, an inverse linear correlation was observed between repellent duration and insensible wa... | 240,895 | [
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Highly iodinated fibrinogen: a new thrombus-localizing agent. | We have examined radioiodinated fibrinogen prepared at high levels of iodination as an agent for improved in vivo thrombus detection. Fibrinogen containing 25, 50, and 100 atoms of iodine per molecule is prepared by an electrolytic procedure and is compared with conventional radiolabeled fibrinogen (less than 0.5 iodin... | 240,916 | [
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Nonclassical nicotine antagonists. | A series of "nonclassical" nicotine antagonists was synthesized and compared to the "classical" nicotine antagonist, hexamethonium, by means of the isolated guinea pig atria preparation. 2 was found to be the most potent, followed by hexamethonium and the other antagonists. With the exception of 5, the bisquaternary co... | 240,939 | [
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Synthesis and antibacterial properties of methylsulfinyl and methylsulfonyl analongs of some nitrofurans. | The sulfoxides 5-methylsulfinyl-2-furaldehyde semicarbazone (2) and 1-[(5-methylsulfinyl-2-fufurylidene)amino]hydantoin (3) as well as the sulfones 1-[(5-methylsulfonyl-2-furfurylidene)animo]hydantoin (1) and 1-(5-methylsulfonly-2-furyl)-2-(6-amino-3-p-ridazyl)ethylene hydrochloride (4) have been prepared and tested fo... | 240,940 | [
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Situations related to drinking alcohol. A factor analysis of questionnaire responses. | Problem and nonproblem drinkers indicated on a questionnaire the degree to which they used alcohol in certain situations. The responses were factor analyzed and seven factor scales were developed. It is suggested that the questionnaire could be used as an initial diagnostic step leading to specific treatment alternativ... | 240,972 | [
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Self-reported coping behavior of wives of alcoholics and its association with drinking outcome. | The frequency of the use of coping behavior by wives of alcoholics was found to be related to their husband's drinking outcome. In general, a high frequency of coping behavior was associated with a poor outcome, but some components of coping behavior were more likely than others to be linked with a poor prognosis. | 240,978 | [
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Evidence that revascularization by ventricular-internal mammary artery implants increases longevity. Twenty-four year, nine month follow-up. | Revascularization of the heart is a means of relieving symptoms of coronary artery disease--such as angina, fatigue, and dyspnea. The question of whether revascularization prolongs the life of the patient has been debated. My colleagues and I have reviewed our years of experience with patients treated by implantation o... | 240,982 | [
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Energy metabolism of isolated rat thymus cells. | The energy metabolism of rat thymus cells has been investigated using preparations of isolated cells obtained by mechanical treatment of whole organs. The addition of glycolytic substrates such as glucose, pyruvate and lactate stimulates the endogenous respiration of these cells by 50%. On the other hand, succinate, gl... | 241,010 | [
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[The medicinal treatment of anxiety in alcoholism in the withdrawal stage (author's transl)]. | The benzodiazepine preparation Camazepam was tested for its anxiolytic activity and found to be effective. It differs from preparations which have already been in use for a long time, especially by the lack of any hypnotic and muscle relaxant effects. In the clinical trial it was also free from side effects so far as t... | 241,014 | [
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Cerebrospinal-fluid acid base and electrolyte changes resulting from cerebral anoxia in man. | To study metabolic changes in the central nervous system after profound anoxia, we measured changes in cisternal and lumbar cerebrospinal fluid. Acid-base values and electrolyte concentrations were determined in cisternal and lumbar fluid from 12 severely anoxic patients (cardiac arrest), and from 15 within 24 hours af... | 241,018 | [
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Effects of stress on catecholamines and tyrosine hydroxylase activity of individual hypothalamic nuclei. | The effects of acute stress on norepinephrine (NE) and dopamine (DA) concentrations and of repeated stress on tyrosine hydroxylase (TH) activity were measured in individual hypothalamic nuclei and other rat brain regions. A microdissection technique and radioisotopic enzymatic assays enables these studies to be perform... | 241,031 | [
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Effects of ganglionic and beta-adrenergic blockade on cardiovascular responses to the bisenoic prostaglandins and their precursor arachidonic acid. | Arachidonic acid (AA) 300 mug/kg, and PGE2, 5 mug/kg consistently produced a decrease in systemic arterial pressure in anesthetized dogs. PGF2alpha, 5 mug/kg, produced a pressor response. All three compounds increased myocardial contractile force, but the magnitude of the change following AA was less prominent. After g... | 241,082 | [
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Antagonism of fenoterol against beta-blocking drugs bunitrolol and practolol in asthmatics. | In 4 X 10 young white male histamine-sensitive asthmatics without bronchitis or emphysema, the antagonism of fenoterol (40 mug) to bunitrolol (2.5 and 5 mg) or practolol (20 and 30 mg) was tested in an open comparative trial. Pulse frequency and several physiological parameters were determined before and after histamin... | 241,102 | [
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A fish in extreme alkalinity. | Tilapia grahami (Boulenger), a small cichlid fish, inhabits extremely alkaline water where the total CO2 concentration exceeds 200 meq.L(-1), osmolality is about 600 mosm.L(-1), pH ranges between 9.6 and 10.5 and temperature may be 43 degrees C. Venous blood drawn anaerobically by heart puncture had pH values as high a... | 241,103 | [
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Electrochemical improvement of the performance of PO2 electrodes. | Rotating ring-disc electrode studies have indicated that relatively large quantities of hydrogen peroxide ion, HO2-, are produced when oxygen is reduced at a platinum or gold polarographic electrode surface. The electrochemical reduction processes are improved and the quantity of HO2- is reduced by using alkaline buffe... | 241,106 | [
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Bacterial flora in relation to cataract extraction. I. Material, methods and preoperative flora. | The conjunctival flora of 499 patients was studied the day before cataract extraction, no antibiotics or chemotherapeutical agents had been used before admission. Staphylococcus albus was by far the most common micro-organism (95.4%), followed by corynebacteria (44%), Staphylococcus aureus (14.9%), gram-negative bacill... | 241,200 | [
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Histochemical demonstration of an LNA-splitting enzyme in the cerebellum of the rat. A aminopeptidase-like reaction localized selectively in the granular layer with acid pH optimum. | Histochemical investigations of leucine aminopeptidase using LNA (L-leucyl-beta-napthylamide) as a substrate reveals a marked enzyme activity selectively localized to the granular layer with inconspicuous reaction in the stratum moleculare and the Purkinje cells in the rat cerebellum. The LNA-splitting enzyme differs f... | 241,202 | [
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Stimulation of adrenergic nerve fibres to the urinary bladder of the rat. | The contraction of the rat detrusor muscle caused by electrical stimulation of the hypogastric or pelvic nerves was followed by relaxation when the nerves were stimulated for a short period. The relaxation was more pronounced when the initial contraction was reduced by atropine. It was found to be mediated by adrenergi... | 241,208 | [
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Influence of amino acids, thiourea and hydroquinone on cellulolytic activity in some Fusarium strains. | Studies were carried out on the influence of various amino acids: cysteine, cystine, methionine, alanine, serine, tryptophan, and of thiourea and hydroquinone on the activity of cellulase synthesized by four strains of Fusarium. It follows from the results obtained that the addition of amino acids, thiourea or hydroqui... | 241,210 | [
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... |
The influence of glucose on simazine decomposition. | Glucose added to soil and to the culture medium of Penicillium citrinum stimulated simazine decomposition. Differences in the rate of simazine decomposition depended on the dose of glucose. Both in soil and in the medium the rate of simazine decomposition was connected with the intensity of development of microorganism... | 241,211 | [
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Effect of chronic alcohol consumption on ethanol and acetaldehyde metabolism. | Hepatic metabolism of ethanol to acetaldehyde by the alcohol dehydrogenase (ADH) pathway is associated with the generation of reducing equivalents as NADH. Conversely, reducing equivalents are consumed when ethanol oxidation is catalyzed by the NADPH dependent microsomal ethanol oxidizing system (MEOS). Since the major... | 241,214 | [
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0.002656137,
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... |
Streptovirudins -- new antibiotics with antiviral activity. The antiviral spectrum and inhibition of Newcastle disease virus in cell cultures. | Streptovirudins are new antibiotics isolated as a mixture of several structurally related compounds from fermentations of Streptomyces griseoflavus (Krainsky) Waksman et Henrici var. thuringensis JA 10124. They possess antiviral activity against RNA and DNA viruses cultivated in chick embryo cells, namely Sindbis, fowl... | 241,229 | [
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0.3841851,
0.6498958,
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Experiences with the adaptation of crimean hemorrhagic fever virus to the CV-1 monkey cell line. | Of several cell lines tested, the CV-1 monkey cell line proved to be the most suitable system for propagation of Crimean hemorrhagic fever (CHF) virus. Two CHF strains could be adapted to this cell line by serial passaging. The viral progeny from these passages was specifically cytocidal and produced plaques in CV-1 ce... | 241,233 | [
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The effect of temperature and urea on virulent and attenuated strains of pseudoabies virus. | Out of 10 virulent strains of pseudorabies virus (PRV), 9 proved to be resistant and 3 out of 4 attenuated strains were sensitive to the temperature of 53 degrees C. No differences were found between attenuated and virulent strains of PRV in their rate of inactivation of 2 M urea; its inactivating effect was enhanced b... | 241,242 | [
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0.005157608,
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Herpesvirus-induced availability of host DNA to exogenous endonuclease. | Deoxyribonuclease I penetrates herpesvirus-infected L cells and degrades host DNA without interfering with viral multiplication. The DNA of uninfected control monolayers of L cells, disrupted by scraping, is similarly attacked. In contrast, undisturbed L cells are not affected. This suggests that altered cell membrane ... | 241,244 | [
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0.1462532,
0.4572519,
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Thin layer chromatographic identification of phenothiazines in urine specimens. | Two newly developed, thin layer chromatographic (TLC) solvent systems are presented to separate and identify commonly used phenothiazines in the presence of other drugs in urine specimens. These solvent systems are 1) ethyl acetate: n-butanol: concentrated ammonium hydroxide (89:10:1.5) and 2) ethyl acetate: O-dichloro... | 241,257 | [
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[Comparative study of post-anesthesia awakening and behavior following alfatesine and pentothal]. | A study of behaviour during the awakening of subjects which had been anaesthetized with a single dose of Alfatesine or of Pentothal was undertaken. This comparison between two anaesthetic drugs offers the opportunity to make, firstly, a critical analysis of the methods of exploration of anaesthetic awakening which are ... | 241,272 | [
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0.08598613,
0... |
[Perforation of the cervical esophagus during tracheal intubation. Apropos of a personal case]. | On the occasion of a personal case of perforation of the cervical oesophagus by laborious tracheal intubation which had necessitated the use of a rigid stilet, we found seven similar cases in the literature since 1971 which can be added to the 16 collected by DUBOST in 1971. We analyse the etiological circumstances, th... | 241,274 | [
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0.3547852,
0.1579907,
-0.046... |
Bisulfite induced lipid oxidation. | Bisulfite (0.5 to 10 millimolar) initiates oxidation of lipids in aqueous emulsions of corn oil in a dose-dependent manner as measured by reaction with thiobarbituric acid. The reaction is effectively quenched by the antioxidant, 2,6-dit-butyl-4-hydroxymethyl phenol as well as by Mn+2 (10(-5)-10(-3)M). The latter obser... | 241,301 | [
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0.3310542,
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Ectopic apudocarcinomas and associated endocrine hyperplasias of the foregut. | Foregut endocrine polypeptide-secreting APUD cells (Amine-Precursor-Uptake and Decarboxylation), in their embryologic migration from neural crest to foregut may become "arrested" in the mesoderm or in other ectopic locations. They may become hyperplastic, adenomatous or malignant. Eight illustrative patients are report... | 241,302 | [
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0.01182178,
0.5072913,
0.1725079,
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Antigenic comparison of swine influenza virus isolates. | Cross hemagglutination inhibition (HI) and neuraminidase inhibition (NI) tests demonstrated strong antigenic relationship between A/Swine/Wisconsin/1/73 (SW/73) and A/Swine/Shope/15/31 (SW/31) influenza viruses. An eigthyone fold purification of virus was achieved by adsorption and elution followed by differential ultr... | 241,310 | [
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0.322383,
0.1446674,
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-... |
Pyridine nucleosidase in bull semen. II. Biochemical properties. | It is most likely a single enzyme (NAD+ nucleosidase) present in semen from most bulls which hydrolyses the ribosyl pyridinium bond in both NAD and NADP. This conclusion is based on the following results: (i) each of 12 semen samples containing nucleosidase activity hydrolysed NAD at the same rate as NADP (r = 0.99); (... | 241,313 | [
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0.1402828,
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0.05709712,
0.1914336,
0.2880993,
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0... |
The purification and properties of L-histidine--2-oxoglutarate aminotransferase from Pseudomonas testosteroni. | 1. Inducible L-histidine--2-oxoglutarate aminotransferase was purified some 170-fold from extracts of Pseudomonas testosteroni. 2. The preparation showed only one major component after electrophoresis on polyacrylamide gels, though additional minor bands were observed when samples concentrated on a DEAE-cellulose colum... | 241,324 | [
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0.06867585,
0.4674848,
0.00992413,
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Pharmacological studies of 1-(o-chlorophenyl)-2-tert.-butylaminoethanol (C-78), a new bonchodilator. | The bronchodilating effects and other related pharmacological properties of 1-(o-chlorophenyl)-2-tert.-butylaminoethanol-hydrochloride (C-78) were studied in comparison with those of isoproterenol, salbutamol and clorprenaline. C-78 was found to produce a bronchodilating effect 2--10 times stronger and considerably wea... | 241,356 | [
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0.1... |
Phospholipase A and lysophospholipase activity of the epidermis. | Phospholipase A and lysophospholipase activities have been demonstrated in cow snout epidermis. The phospholipase A activity was dependent on Ca2+ ions and the pH for optimum activity was between 6-1 and 7-4. | 241,370 | [
0.2004375,
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Enzymatic activity of the second component of complement. | Isolated C2 and C2i preparations were able to hydrolyze a number of synthetic esters containing basic amino acids, among which N-alpha-acetylglycyl-L-lysine methyl ester (AcGlyLysOMe) was most susceptible. The cleaving activity was a property of the C2 molecule, since it correlated with the presence of C2 on analyses o... | 241,376 | [
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Magnesium-induced self-association of calf brain tubulin. I. Stoichiometry. | The self-association of calf brain tubulin at pH 7.0 in the presence of magnesium ions has been examined by velocity sedimentation. The schlieren patterns were analyzed by methods described by Gilbert and by Cox. The observed process is best described in terms of a rapidly reversible progressive self-association of the... | 241,382 | [
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Nonequivalence of the metal binding sites in vanadyl-labeled human serum transferrin. | Vanadyl ion, VO(IV), has been used as an electron paramagnetic resonance (EPR) spin label to study the metal-binding properties of human serum transferrin in the presence of bicarbonate. Iron-saturated transferrin does not bind the vanadyl ion. Room temperature titrations of apotransferrin with VO(IV) as monitored by E... | 241,383 | [
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0.1916602,
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0.0373... |
Crystallization and partial characterization of glutamate dehydrogenase from ox liver nuclei. | Glutamate dehydrogenase have been obtained in crystalline form from purified ox liver nuclear fractions. The enzyme appeared homogeneous, as judged by several electrophoretic techniques at two pH values. A comparative study with the widely known ox liver mitochondrial glutamate dehydrogenase revealed several common fea... | 241,385 | [
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Reactivation and aging of diphenyl phosphoryl acetylcholinesterase. | Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) is readily in hibited by 10(-5) M diphenylphosphorochloridate even though the inhibitor hydrolyzes in a few seconds. The fluoridate is a much weaker inhibitor. The inhibited enzyme, diphenyl phosphoryl enzyme spontaneously recovers only about 50% of its activit... | 241,402 | [
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... |
Studies on phospholipase C from Pseudomonas aureofaciens. I. Purification and some properties of phospholipase C. | Phospholipase C (phosphatidylcholine cholinephosphohydrolase, EC 3.1.4.3) from Pseudomonas aureofaciens was purified 3600-fold from the culture filtrate with a recovery of 1.6%. Purification was performed with the useof (NH4)2SO4 precipitation, Sephadex G-100 gel filtration and by ion-exchange chromatography on DEAE-Se... | 241,404 | [
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0.... |
Conformational studies on parvalbumins by circular dichroism. | Structural variations of two parvalbumins, Whiting III and Pike III, in various denaturing conditions, have been studied by circular dichroism. CD signals are depressed from 4 urea. For Pike III, acidic pH, sodium dodecyl sulfate or complete removal of Ca2+ show little effect in the far ultraviolet region but rather st... | 241,410 | [
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0.02969138,
0.3904829,
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0... |
High molecular weight deoxyribonucleic acid polymerase of LF hepatoma. Purification and properties. | A high molecular weight DNA polymerase has been purified from the cytosol of a fast growing hepatoma: LF hepatoma. This enzyme sediments at 11.3 S under polymerization reaction conditions (6 mM KCl) and at 8.3 S in higher salt concentrations (200 mM KCl). In either case, no activity is seen in the 3 to 4 S region where... | 241,419 | [
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... |
Effect of plasma lipoproteins and lecithin-cholesterol dispersions on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase of isolated rat hepatocytes. | Incubation of rat hepatocytes for 3 h in a medium containing amino acids, salts and albumin resulted in a 2-fold increase in the activity of 3-hydroxy-3-methylglutaryl-CoA reductase. Inclusion of 10% human plasma, rat serum or dialysed rat serum in the medium resulted in an approximate 7-fold increase in reductase acti... | 241,422 | [
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0.... |
Isolation of peroxisomes from the dog kidney cortex. | The present study was undertaken to separate peroxisomes of the dog kidney cortex by the methods of discontinuous sucrose density gradient and zonal centrifugation. The separation of subcellular particles was evaluated by measuring the activities of reference enzymes, beta-glycerophosphatase for lysosomes, succinate de... | 241,425 | [
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0.2019493,
0.02157931,... |
Hydrolysis of nucleoside phosphates: IV. The metal ion-nucleic base interaction in the Cu2+-promoted dephosphorylation of the 5'-di- and 5'-triphosphates of cytidine, inosine and guanosine, and their protection toward hydrolysis by coordination to Cu(2,2'-bipyridyl)2+. | The dephosphorylation of CTP, GTP, ITP, ATP, CDP, GDP, IDP and ADP was characterized by measuring the first-order rate constant (50 degrees; I = 0.1, NaClO4) in dependence on pH (2 to 10). Except with CTP and CDP, the reactions are significantly accelerated by Cu2+ and pass through pH optima. By computing the pH depend... | 241,426 | [
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Glutamine synthetase and glutamyltransferase in developing chick and rat tissues. | Concomitant determination of gamma-glutamine-hydroxylamine-glutamyltransferase (GT) and gamma-glutamyl hydroxamate synthetase (GS) activities in chick retina, brain and liver between the 13th day of incubation and a day after hatching showed that while both activities increased late in incubation, in neural tissues the... | 241,431 | [
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Preparation and monitoring of marijuana smoke condensate samples. | The objective of this study was the production of smoke condensate from the marijuana cigarettes on schedule for the bioassay study and involved quality control on each batch of smoke condensate. Examination of the condensate production data (tables 1 and 2) reveal that it is not possible to strictly control the butt l... | 241,444 | [
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Phosphoenolpyruvate carboxylase of Thiobacillus thioparus. I. General properties. | Phosphoenolpyruvate (PEP) carboxylase (orthophosphate:oxalacetate carboxylase (phosphorylating), EC 4.1.1.31) was purified 19-fold from the obligate chemoautotroph, Thiobacillus thioparus. Michaelis constants for the substrates were found to be 0.44 mM for phosphoenolpyruvate, 0.89 mM for bicarbonate, and 0.37 mM for m... | 241,472 | [
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The isolation of carcinoembryonic antigen from tumor tissue at neutral pH. | Carcinoembryonic antigen (CEA) was purified from tumor tissue under mild conditions at neutral pH by a procedure that utilized affinity chromatography on concanvalin A. Further purification by gel filtration provided CEA in 10 to 20% yield and 10% purity. Antibody to this preparation was rendered specific for CEA by ad... | 241,482 | [
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Effect of added nucleophiles and pH on alpha-D-mannosidase-catalyzed reactions. | The effect of (1) added nucleophiles, (2) the concentration of water, and (3) pH on the alpha-D-mannosidase-catalyzed hydrolysis of substituted phenyl alpha-D-mannopyranosides has been investigated.. A two-step mechanism, with formation of a mannosyl-enzyme complex, is proposed. With the phenyl alpha-D-mannopyranosides... | 241,487 | [
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Serum ionized calcium by electrodes: new technology and methodology. | We report experience measuring serum ionized calcium (Ca2+) with new solid-state, specific calcium ion dip electrodes in a commercially available system for automated electrode measurments which permits stable measurements on thirty samples with up to six different electrodes simultaneously. The system provides electro... | 241,516 | [
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Effect of acidosis on patients with myocardial ischemia. | Reduction in pH is known to decrease O2 affinity (Bohr effect) and increase the rate of O2 release from blood. It provides a potential mechanism for increasing O2 transport to the myocardium. Fifteen patients with refractory, chronic angina were studied by treadmill exercise tolerance tests and whole blood-oxygen relea... | 241,534 | [
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Influence of pharmacologic agents on tissue metabolism in circulatory shock. | Our research activities have been oriented to the effect of pharmacologic agents on tissue metabolism in the low flow state of circulatory shock. Specifically, we have been most interested in the effect of glucocorticoids on cellular metabolism because these agents exert a reproducible protective effect during septic a... | 241,591 | [
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The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. | Alclofenac and D-penicillamine were compared under controlled, double-blind conditions in the treatment of 35 patients with active rheumatoid arthritis over a period of 26 weeks. The principal aim of the study was to investigate any relationships between changes in clinical status and changes in concentrations of three... | 241,598 | [
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Effect of 3-methylcholanthrene pretreatment on glucuronidation and sulfation in perfused rat liver. | The metabolism of p-nitro[14C]phenol (PNP) was studied in perfused rat liver. Metabolites were identified in perfusate and bile. The perfusion system containing 0.5 mM PNP, at the start, converted the phenol within 2 hr to p-nitrophenyl glucuronide (PNPGA), 31.4% in perfusate and 21% in bile; p-nitrophenyl sulfate (PNP... | 241,622 | [
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Adsorpition of tryptophan onto calcum carbonate surface. | Adsorption of tryptophan onto CaCO3 at constant ionic strength (0.05 M Nacl) and from dilute aqueous solution (10(-4) M to 10(-3) M tryptophan) is reported. Adsorption was primarily determined by the charge characteristics of both the adsorbate amino acid and adsorbent CaCO3. When both adsorbate and adsorbent are semic... | 241,629 | [
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The role of histamine in burn, tourniquet and endotoxin shock in mice. | The release of histamine and mortality was studied in mice after various types of experimental shock. In burn shock, serum histamine rose significantly after injury, but there was no correlation between increased serum histamine and high mortality as a consequence of several therapy regimens. For example, after treatme... | 241,652 | [
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ACTH-like peptides and opiate receptors in the rat brain: structure-activity studies. | The present study aims at further identifying the interaction of ACTH-like peptides and rat brain opiate receptors in vitro. The sequence ACTH4-10 is crucial with respect to affinity since it is the shortest sequence to inhibit the binding of [3H]-dihydromorphine and [3H]-naltrexone to these receptors. A second active ... | 241,656 | [
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Ergoline derivatives. Note XIII (1) alpha-adrenergic blocking drugs. | The synthesis and the pharmacological activities of 24 analogues of the alpha-adrenergic blocking drug, nicergoline (I b), are reported. The majority of the new compounds were found to be less active than (I b): the structure-activity relationships are presented and discussed. | 241,664 | [
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Membrane effects on hepatic microsomal glucose-6-phosphatase. | 1) Rat liver microsomes exhibit only a weak hydrolyzing activity towards galactose 6-phosphate. Disruption of the microsomal vesicles does not change the apparent Michaelis constant for this substrate but enhances the apparent maximum velocity. 2) The inhibition of microsomal glucose-6-phosphatase (EC 3.1.3.9) by galac... | 241,694 | [
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Chicken (Gallus gallus) hemolytic complement: optimal conditions for its titration. | The effect of pH, ionic strength, cation concentration, ethylenediaminetetraacetic acid trisodium salt (Na3EDTA), time and temperature were studied to determine the optimal conditions for titrating the hemolytic complement (C) activity in sera of chicken (Gallus gallus). Swine erythrocytes (E) sensitized with rabbit an... | 241,720 | [
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Isolation and characterization of the newly evolved ebg beta-galactosidase of Escherichia coli K-12. | The ebg beta-galactosidase of Escherichia coli K-12 strain LC110 has been purified and characterized. Strain LC110 is a Lac+ revertant of a mutant with a deletion of the lacZ beta-galactosidase gene. Its new ebg beta-galactosidase activity was shown to be due to a discrete protein, immunologically unrelated to lacZ bet... | 241,745 | [
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A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties. | The more than 2,300-fold purification of a DNA polymerase from the embryos of Drosophila melanogaster is described. The enzyme, which forms a single band on gel electrophoresis, has a molecular weight of about 87,000 and a pH optimum of 8.5. A divalent metal is required for activity, Mg2+ being preferred with activated... | 241,752 | [
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Some relations between dissolution rates and physical parameters of a drug in aqueous micellar solutions of a non-ionic surfactant. | Dissolution rates of salicylic acid from a constant surface area into a series of aqueous micellar polysorbate 20 solutions at pH 1-0 to 4-0 have been measured using two different methods; a stirred beaker and a rotating disc technique. The micellar molecular weight of polysorbate 20 has been obtained from light scatte... | 241,807 | [
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The effect of ageing on the rheological properties of gelatin gels. | The effect of ageing at 4 degrees on the viscoelastic properties of 1-5 and 2-0% acid and alkaline processed gelatin gels has been investigated. Viscoelastic properties were not markedly affected by ageing time although evidence of a decrease in gel structure with increasing ageing time was apparent. This has been tent... | 241,808 | [
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The metabolism of dibenzylamine: identification of NN-dibenzylhydroxylamine as the major in vitro metabolic product from rabbit fortified hepatic homogenates. | A study of the in vitro metabolism of dibenzylamine with fortified rabbit liver 9000 g supernatant fractions has shown that N-oxidation is the major metabolic process. Of the total amount of dibenzylamine metabolized, 90% is converted to NN-dibenzylhydroxylamine. The primary amine, benzylamine, is formed to the extent ... | 241,809 | [
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Tyrosine hydroxylase activity in rat brain regions after chronic treatment with +/--propranolol. | Rats were injected twice daily with +/--propranolol (6 mg kg-1 day-1) for 14 days and killed 16 h after the final injection. Tyrosine hydroxylase activity was measured in both soluble and particle-bound forms in various brain regions. The activity of the soluble enzyme was not significantly altered by propranolol treat... | 241,811 | [
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Preceramic and postceramic solder joints. | This investigation evaluated preceramic and postceramic soldering procedures. Three gap spaces and two soldering methods were evaluated. Wider gaps produced stronger joints. The strongest joints were achieved by using wider gaps and the oven soldering technique. Very wide gaps (0.76 mm.) are not recommended because of ... | 241,849 | [
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Strontium, lead and nickel incorporation into mouse calvaria in vitro. | Incorporation of strontium, lead and nickel radioisotopes was studied in mouse calvaria in tissue culture. About 90% of the incorporated strontium and 5-12% of the lead were recovered in the mineral phase of the calvaria (hot acid soluble fraction), whereas the nickel was recovered mainly in the organic phase (hot alka... | 241,957 | [
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... |
Exercise-induced asthma and competitive athletics. | Although swimming is their optimum sport and exercise, asthmatics should be encouraged to embrace a full and varied program of sport and physical education. Sports exclusion should be infrequent as possible. Pre-exercise cromolyn sodium with significantly reduce exercise-induced asthma (EIA) and salbutamol may be admin... | 241,969 | [
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... |
Bacteriophage T4 whiskers: a rudimentary environment-sensing device. | The 400 A filaments or "whiskers," which extend outward from the collar region of the phage, control retraction and extension of the tail fibers in response to certain environmental conditions. The tail fibers of normal phage retract in the absence of a required adsorption cofactor, at low pH, at low ionic strength, at... | 242,007 | [
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0.1050274,
-0.... |
Oxygen consumption and conservation during apnea in the anesthetized dog. | Apnea was initiated by clamping off the tracheal tube in 6 anesthetized dogs. Bradycardia, reduction in cardiac output and peripheral vasoconstriction developed gradually throughout the entire apneic period. O2 consumption during apnea was measured by monitoring the rate of O2 removal from the lung (VLO2), from the ar... | 242,051 | [
-0.0117723,
-0.1014361,
-0.5105035,
-0.3094719,
0.04903077,
0.1081957,
0.1046064,
-0.4173272,
-0.0746235,
-0.1025567,
0.3820552,
-0.1314131,
-0.1133022,
-0.3269308,
-0.1352443,
-0.1368522,
-0.3642128,
0.277516,
0.1892655,
-0.1209311,
-0.1711249,
0.2861102,
0.1234118,
-0... |
The depressor effect of dopamine on the electrical and mechanical activities of cat small intestine. | Effects of externally applied dopamine and other adrenergic stimulants on the electrical and mechanical activities of the cat small intestine were observed by using pressure electrodes. DOPA and dopamine reduced the spike and mechanical activities. The effects of dopamine were suppressed by treatment with phentolamine,... | 242,098 | [
-0.06652228,
-0.1674821,
-0.1030589,
-0.002119201,
0.1715416,
-0.5029491,
-0.3404036,
-0.2319355,
-0.1635573,
0.06107543,
-0.07169922,
-0.3281408,
0.1423573,
0.0434505,
-0.3641597,
0.231435,
-0.6671473,
0.4057759,
-0.0479788,
0.1953434,
0.008939357,
-0.0481119,
0.050631,
... |
[Study of the enzyme activity of serum cystine aminopeptidase in man and animals in relation to the pH of the medium]. | The authors studied the splitting dynamics of the synthetic chromogenic substrate (S-benzyl-L-cysteine-p-nitroanilide) specific of serum cystine aminopeptidase, depending on a wide range of pH (from 2.5 to 8.0) by means of an enzymatic serum system of pregnant women and selected animals (sheep, cows, sewer-rats), compa... | 242,112 | [
-0.05021911,
-0.1658849,
-0.2784011,
0.07781965,
-0.04974291,
-0.3932786,
-0.4064769,
-0.09992921,
0.3189025,
0.01613843,
0.02311042,
0.2249865,
0.06282562,
0.2089579,
-0.1233429,
-0.2430816,
-0.7871701,
0.1332428,
-0.002096971,
0.1696606,
0.2150211,
0.2726595,
-0.2214967... |
[Pathogenesis of aleutian mink disease. VII. Chronic hepatitis with bile duct proliferation]. | Aleutian disease is a chronic persistent viral infection of mink characterized by hypergammaglobulinema, generalized plasmacytosis, sclerosing glomerulonephritis, polyarteritis, and plasma cell hepatitis with bile duct proliferation. The development of hepatic lesions was studied both light- and electron-microscopicall... | 242,113 | [
-0.1090721,
-0.06870238,
0.08110348,
0.2073972,
0.3969565,
-0.01380496,
0.1455477,
0.07028666,
-0.04772995,
0.1450918,
0.05278388,
-0.3180318,
0.1846222,
-0.006324559,
-0.09246483,
-0.0338241,
-0.01289387,
0.2637267,
0.2900928,
0.08780505,
0.5241905,
0.1065601,
-0.0380903... |
Studies on the excystment of trematode metacercariae in vitro. | Excystment of metacercariae of Parorchis acanthus, Posthodiplostomoides leonensis, Posthodiplostomum sp. and Clinostomum tilapiae was found to be an active process initiated by the metacercariae when the correct physico-chemical conditions exist in the environment; but in the excystment of Posthodiplostomum nanum the m... | 242,137 | [
-0.1941258,
-0.3309783,
0.05069505,
0.01945488,
-0.6381186,
-0.2018497,
-0.1659988,
-0.3090197,
0.1270294,
-0.05522584,
0.006878263,
-0.1668583,
0.1205705,
-0.1899542,
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-0.1950595,
-0.5416415,
0.1685435,
-0.1456687,
0.2071109,
0.2425408,
0.08675233,
0.1946017,
... |
Properties of the glycoprotein laccase immobilized by two methods. | Laccase (p-diphenol:oxygen oxidoreductase; EC 1.10.3.2) from Neurospora crassa has been immobilized by two different procedures: (1) Covalent attachment to Sepharose 4B activated with cyanogen bromide, and (2) Adsorption to Concanavalin A-Sepharose via the carbohydrate moiety. Except for small changes in the Michaelis-... | 242,172 | [
-0.01304579,
-0.1314451,
0.08489406,
0.009312784,
-0.1635888,
-0.169204,
-0.2570376,
-0.05777162,
0.03865187,
0.2796221,
0.1987118,
-0.04945338,
-0.0181388,
-0.1576535,
-0.6393354,
0.2976243,
-0.6136183,
-0.04228764,
0.3374356,
-0.02806186,
0.1823042,
0.07394902,
-0.21875... |
[Androgenic treatment with depot mesterolone in dyspermia]. | The clinical use of testosterone, and more recently of orally administered mesterolone in disorders of male fertility is of limited therapeutic efficacy, as shown by data found in the literature. On the basis of these considerations, the authors have tested mesterolone cyclopentylproprionate in 15 subjects suffering fr... | 242,176 | [
-0.1027868,
-0.04819595,
0.1319947,
-0.09669391,
-0.01820605,
-0.08157735,
-0.1612605,
-0.07183907,
-0.175739,
-0.1130427,
0.1201618,
-0.110168,
0.03166237,
0.1621652,
-0.5923377,
-0.3061961,
-0.4116442,
0.097214,
0.04600448,
0.1702037,
0.3688126,
0.3855865,
-0.03314598,
... |
Antihypertensive beta blocking action as related to renin and age: a pharmacologic tool to identify pathogenetic mechanisms in essential hypertension. | Three hundred fifteen patients with essential hypertension were classified according to low (18 percent), normal (59 percent) or high (23 percent) renin-sodium index. The proportion of patients with low renin hypertension progressively increased with increasing age and blood pressure, there being no difference between ... | 242,209 | [
-0.06988668,
-0.1282905,
-0.5117732,
-0.149239,
0.15361,
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-0.1687907,
0.225422,
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-0.1442957,
0.4271453,
0.06762111,
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0.1050143,
-0.2620046,
0.4311971,
0.1743882,
0.2044417,
-0.05643286,
0.3... |
Abnormal forms of bacteria produced by antibiotics. | Subinhibitory concentrations of antibiotics can produce in vitro aberrant forms of bacteria that are similar to those observed in specimens and cultures from patients being treated with antibacterial agents. Eight species of bacteria were grown on membranes placed on agar containing subinhibitory concentrations of nine... | 242,211 | [
0.0630521,
-0.04031573,
-0.3075123,
0.1601023,
-0.02783957,
0.09879238,
-0.1791688,
-0.2969195,
0.1238762,
-0.04183852,
0.1667794,
0.04495203,
-0.2174439,
0.5736975,
-0.2540306,
0.2643114,
-0.3223141,
0.06213436,
0.2354586,
-0.03345191,
0.3730076,
0.2333329,
0.3214447,
... |
Effect of volatile fatty acids on water and ion absorption from the goat colon. | The absorption of volatile fatty acids (VFA) and the influence of VFA on the net transport of inorganic electrolytes and water were examined in the temporarily isolated colon of the conscious goat. Perfusion of the colon with a solution similar in content to that normally present in the cecal outflow showed that the ne... | 242,224 | [
-0.3004955,
0.07893176,
-0.2965703,
-0.3107845,
0.2659483,
-0.2683127,
-0.01586114,
0.03965598,
-0.2055564,
-0.2315703,
0.04671211,
0.05991533,
0.09051798,
-0.001847648,
-0.1473603,
-0.1356777,
-0.2482517,
0.05746353,
-0.004846581,
-0.1606697,
0.005024713,
0.2320091,
-0.0... |
Mammalian erythrocyte glutathione reductase: kinetic constants and saturation with cofactor. | Glutathione reductase (GR) was studied in erythrocytes of horses, cats, dogs, and man. Glutathione reductase activity was measured in hemolysates with and without preincubation of hemolysates with flavinadenine dinucleotide. The percentage saturation of GR apoenzyme with cofactor (flavin-adenine dinucleotide) was lower... | 242,245 | [
-0.2434225,
0.0006868302,
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0.09513853,
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0.3848563,
0.005135873,
-0.2912796,
0.03520421,
0.3195468,
0.07706223,
0.008822186,
0.2950974,
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-0.529371,
0.2041578,
0.2512113,
0.2311977,
-0.188096,
0.2836157,
-0.1711583,
... |
A comparison in vivo dacron wool (Swank) and polyester mesh (Pall) micropore blood transfusion filters in the prevention of pulmonary microembolism associated with massive transfusion. | Experiments were performed to compare the effectiveness in vivo of the two most widely used micropore blood transfusion filters in preventing detrimental physiologic changes associated with transfusion of microaggregate-containing blood. Exchange transfusion with stored blood having an elevated screen filtration pressu... | 242,282 | [
-0.09778942,
0.5029687,
0.01530477,
0.1975026,
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0.07698477,
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0.2902986,
0.1006216,
0.166893,
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-0.2080087,
-0.2122264,
0.6014667,
0.05981008,
0.1217395,
0.08170199,
-0.1265513,
... |
Effect of temperature, salts, pH, and other factors on the development of peritrichous flagella in Vibrio alginolyticus. | The development of peritrichous flagella and, consequently, swarming of Vibrio alginolyticus depend on a complex relationship between temperature, salt concentrations and pH. At temperatures above 28 degrees C V. alginolyticus did not develop peritrichous flagella unless certain minimal concentrations of NaCl are prese... | 242,290 | [
-0.1208352,
0.02162178,
-0.2772488,
0.05943508,
-0.1071473,
0.08474611,
0.06917266,
0.2320971,
-0.2503876,
-0.0705731,
0.1765334,
0.2084192,
-0.2278116,
-0.08969516,
0.01000616,
-0.2985526,
-0.009598418,
0.1790525,
-0.08192345,
0.4008739,
0.2823875,
0.1654999,
-0.2489746,... |
Catabolism of D-fructose and D-ribose by Pseudomonas doudoroffii. II. Properties of 1-phosphofructokinase and 6-phosphofructokinase. | 1. The 1-P-fructokinase (1-PFK) and 6-P-fructokinase (6-PFK) from Pseudmonas doudoroffii were partially purified by a combination of (NH4)2SO4 fractionation and DEAE-Sephadex column chromatography. The pH optima of these enzymes were 9.0 and 8.5, respectively. 2. When the concentrations of the substrates of the 1-PFK r... | 242,298 | [
-0.1380376,
0.05335518,
-0.3059528,
0.05467694,
0.1710514,
0.01048472,
0.1877014,
0.3023971,
-0.3591987,
-0.03057874,
0.3252763,
0.01838779,
-0.1812617,
0.38078,
-0.4890469,
-0.06793532,
-0.1624913,
0.2047551,
0.0654577,
0.1713845,
0.6452367,
-0.1650353,
-0.2755961,
0.1... |
A comparison of the activity of phosphatidylinositol phosphodiesterase against substrate in dispersions and as monolayers at the air-water interface. | The activity of phosphatidylinositol phosphodiesterase, purified from rat brain, against substrate in three forms, (a) multibilayer liposomes, (b) single bilayer vesicles of phosphatidylinositol and (c) phosphatidylinositol oriented as monolayers at the air-water interface, was examined. The reaction rate was similar a... | 242,322 | [
-0.2645095,
-0.01786051,
-0.237696,
-0.4646889,
0.06783188,
-0.1986357,
-0.1323567,
0.1044236,
-0.1650795,
0.0139643,
0.06718322,
0.09572992,
-0.01168804,
-0.06578601,
-0.8336805,
0.0706866,
-0.5444639,
0.0378161,
-0.03964056,
0.3429754,
0.406128,
0.2768444,
0.09161335,
... |
Unusual Pseudomonas corneal ulcers. | Two rare species of Pseudomonas were isolated from corneal ulcers in two patients. In the first case P. acidovorans was isolated and suspected as the primary pathogenic microorganism in human disease. In the second case P. stutzeri was isolated from ocular sources, but this is the first report of its role in causing co... | 242,909 | [
-0.05292526,
-0.4173629,
-0.06368238,
-0.1117947,
0.1466946,
0.1353794,
-0.2349189,
0.009762517,
0.3989046,
0.1952844,
0.1992036,
0.001159459,
-0.3057503,
-0.3610329,
0.1941947,
-0.2291396,
-0.152966,
0.3972354,
0.13024,
0.1530278,
-0.08158085,
0.387832,
-0.06923524,
0.... |
[Prevention and therapy of respiratory distress syndrome in premature infants by means of bromhexine metabolite VIII. Animal experimental studies on the therapeutic efficacy of bromhexine metabolite VIII in premature respiratory distress syndrome]. | In preparing a clinical study 14C-labelled bromhexine metabolite VIII was applied intraamnially in animal experiments. The distribution was measured in different maternal and fetal organs by thinlayer chromatography and autoradiography. A complete placental passage was found in both directions. An organspecific accumul... | 242,957 | [
-0.03490084,
0.01389111,
-0.2990273,
0.08607647,
0.3701132,
-0.08230577,
-0.2351107,
-0.1419435,
-0.1176313,
-0.07955662,
0.1689603,
-0.1351393,
0.1668536,
0.1005804,
-0.3398788,
-0.1106381,
-0.4165089,
0.112571,
0.001632522,
0.1874128,
0.1557721,
0.3871679,
-0.09795964,
... |
[Cardiovascular side effects of tricyclic psychopharmaca under special consideration of the ECG (author's transl)]. | The cardialvascular side effects of tricyclic psychopharmaca.- alteration of blood pressure and heart rate in connection with hemodynamic effects, the "antiarrhythmic activity" and the abnormal ECG-findings - are reviewed. The ECG-changes are discussed in detail. They can be divided in disturbances of rhythm, conductio... | 242,959 | [
-0.1469333,
-0.215436,
-0.3789925,
-0.2200985,
0.42348,
-0.3493722,
-0.4015115,
-0.2901981,
0.05511092,
0.03161756,
0.01858,
-0.06498916,
0.07850788,
0.5251455,
-0.2601721,
0.2162579,
-0.6155366,
0.08652291,
0.08702723,
0.3335315,
0.2175946,
0.15887,
-0.2169117,
0.18180... |
The effect of nutrition education on dietary habits on fifth-graders. | Two fifth-grade classes of 45 students, a majority in the Mexican-American culture, participated in the five month study. One group was taught a series of eight nutrition education units emphasizing weight control while the other group received no nutrition instruction. Pretests and posttests were given to each group a... | 243,082 | [
-0.04631452,
0.09868682,
-0.1580504,
-0.4493056,
0.05464084,
-0.03755554,
-0.02690582,
-0.2184877,
0.09406177,
-0.07978521,
0.1559907,
0.2583706,
-0.1509012,
-0.2271689,
-0.8723484,
-0.04520581,
0.2061569,
0.1502981,
-0.2558787,
0.05847024,
0.01659998,
0.3480238,
-0.06584... |
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