title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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An investigation into the potential hazard to animal health of effluent sludge from dairy factories. | Sixty-three samples of the more solid material (sludge) separated from the effluent plants of dairy factories were examined for the presence of salmonellas and brucellas. Salmonellas were isolated from two samples (S. heidelberg. [1]; S. indiana [1]. No brucellas were isolated. None of the samples supported the growth ... | 239,054 | [
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Activation of alveolar macrophages after lower respiratory tract infection. | Alveolar macrophage function has been studied in relation to bacterial infection of the lower respiratory tract. First, LRT macrophages were examined after exposure of rabbits to Listeria monocytogenes aerosols. Macrophages obtained from the LRT of animals 10 to 48 days after infection were activated, as evidenced by g... | 239,059 | [
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Hapten inhibition of adsorption: specificity of the Sophora japonica lectin. | Since hapten inhibition of precipitation is relatively time consuming, we have developed a hapten inhibition of adsorption assay to explore the sugar binding specificity of the Sophora japonica lectin. Adsorbents were prepared with Sephadex and p-aminophenyl beta-D-galactopyranoside using the CNBr procedure. The abilit... | 239,067 | [
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Cyclic AMP and psoriasis. | Evidence that an adenyl cyclase system is present in all mammalian epidermis is reviewed. This adenyl cyclase is stimulated by at least two separate types of chemicals: catecholamines, which act at a beta-adrenergic receptor site, and prostaglandins of the E series, which act at a separate site. In the psoriatic lesion... | 239,070 | [
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The localization and distribution of gram-positive cocci in normal skin and in lesions of acne vulgaris. | The localization of gram-positive cocci in the normal skin and in the lesions of acne vulgaris was investigated using fluorescein-labeled antiserum raised to gram-positive, coagulase-negative cocci. The cocci were found in 10 of 19 specimens from normal facial skin and in 3 of 11 specimens from the normal skin of the r... | 239,073 | [
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The effect of thiazide diuretics on carbohydrate-induced calciuria in patients with recurrent renal calculi. | Thiazide diuretics could have a beneficial effect in the prevention of recurrent renal calculi by decreasing the exaggerated calciuria which follows carbohydrate ingestionin patients who form calcium oxalate stones. The calciuric response to 100Gm. or oral glucose was studied in 21 patients with recurrent calcium stone... | 239,075 | [
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Enzymic reduction of cystine and glutathione in cultivated human fibroblast from normal subjects and patients with cystinosis. | Cystine glutathione transhydrogenase, cystine-reductase, and glutathion reductase activities were studied in cultivated skin fibroblasts of control subjects and of three patients with cystinosis. Specific activity, pH optima, electrophoretic mobility, and kinetic parameters were described. Evidence for two isoenzyme fo... | 239,080 | [
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An analysis of intermediary metabolism and its control in a fat-synthesizing yeast (Candida 107) growing on glucose or alkanes. | Enzymes of glycolysis, pentose phosphate pathway, gluconeogenesis, tricarboxylate acid cycle, glyoxylate by-pass and fatty-acid biosynthesis were assayed in extracts from Candida 107 grown continuously on glucose under carbon limitation, nitrogen limitation and on n-alkanes. The yeast was therefore either in a lipogeni... | 239,092 | [
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Involuntary movements caused by phenytoin intoxication in epileptic patients. | The case histories of four patients who developed choreoathetoid movements during intoxication with phenytoin are presented. Drug intoxication was confirmed in each case by measuring the serum phenytoin concentration. Drug interactions were, in part, responsible for the occurrence of intoxication in three of them. Phen... | 239,101 | [
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Haemorrhagic and perivenous encephalitis: a clinical-pathological review of 38 cases. | Clinical and pathological data from eight cases of acute haemorrhagic leucoencephalitis (AHL) confirm the previously documented devastating features of this disease. Data from 30 cases of perivenous encephalitis (PVE) associated with viral diseases reveal pathological changes ranging from lymphocytic cuffing of vessels... | 239,102 | [
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Purification and properties of thiamine pyrophosphokinase from parsely leaf. | Thiamine pyrophosphokinase was purified about 8,000-fold from extracts of parsely leaves. The enzyme, as prepared, was homogenous on polyacrylamide gel electrophoresis. The molecular weight of the enzyme, estimated by gel filtration with Sephadex G-150, was approximately 30,000. In 0.05 M Tris-HCl, the enzymic activity... | 239,105 | [
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Factors influencing the excretion and relative physiological availability of pethidine in man. | Factors influencing the urinary excretion of pethidine, norpethidine and pethidine N-oxide have been examined. The proportion of a dose of pethidine excreted unchanged or as norpethidine depends on the urinary pH and the route of administration. Older people appear to metabolize more of the drug and therefore excrete l... | 239,115 | [
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Investigation of changes in the lipid content of guinea-pig lung after anaphylaxis. | A detailed analysis of the lipid content of guinea-pig lung following anaphylaxis in vivo induced by aerosolized antigen showed a significant reduction in all fractions. Anoxia induced by nitrogen produced reductions in the partial glycerides and ethanolamine phospholipid. Exposure to an aerosol of histamine caused a r... | 239,117 | [
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The diffusion of penicillin G and ampicillin through phospholipid sols. | The self-diffusion coefficients of penicillin G and ampicillin have been determined at 25 degrees in water and in the presence of a swamping concentration of electrolyte. The antibiotics diffused through phospholipid dispersions at a reduced rate due to interaction with the lipid aggregates. Ampicillin diffused through... | 239,136 | [
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Dopamine receptor blockade and the neuroleptics, a crystallographic study. | The X-ray structures of 12 drugs of the tricyclic class having varying pharmacological profiles have been examined in detail in an attempt to rationalize the known structure-activity relations of neuroleptic drugs with respect to their ability to block dopamine receptors in the brain. Further evidence is presented in s... | 239,169 | [
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Fluorometric assay of bethanidine in plasma. | A fluorometric method for determining bethanidine in blood plasma is described. The bethanidine is extracted into chloroform, a drug-dye complex with eosin Y is formed, and the fluorescence is measured (excitation, 535 nm; fluorescence, 560 nm). The assay detects 0.02 muM bethanidine (4 ng/ml) in plasma. The relative f... | 239,198 | [
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Interaction of substituted benzoic acids with polysorbate 20 micelles. | Equilibrium solubilities of a series of substituted benzoic acids in different concentrations of polysorbate 20 at controlled pH were measured. The maintenance of pH was achieved using a pH-stat assembly. A linear relationship was found between the amount of benzoic acid solubilized and surfactant concentration. As sol... | 239,206 | [
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Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. V. Enhanced release associated with a granular effect of a benzoquinolizine derivative with reserpine-like properties. | A reserpine-like agent, 2-hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7,-hexa-hydro-11b-H-benzo[a]quinolizine (BQZ), at concentrations that do not inhibit phosphodiesterase activity, produces a marked increase in the outflow of 3-H-dihydroxyphenyl-ethyleneglycol from the isolated, perfused cat slpeen prelabeled... | 239,214 | [
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Postnatal elevation of brain tyrosine hydroxylase activity, without concurrent increases in steady-state catecholamine levels, resulting from dl-alpha-methylparatyrosine administration during embryonic development. | Increased specific activity of tyrosine hydroxylase (TH) in the brains of embryonic and 29-day-old chickens results from exposure to reserpine during the early stages of embryogenesis. We have also reported significant increases in the steady-state concentrations of catecholamines (CAs) in the brains of these 29-day-ol... | 239,220 | [
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Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens. | In rats, a single injection of antipsychotic drugs produced a transitory change in the kinetic state of tyrosine hydroxylase (TH) in striatum and nucleus accumbens. The affinity of TH for 2-amino-4-hydoxy-6,7-dimethyl-5,6,7,8-tetrahydropterine (DMPH4) and the Vmax with respect ot tyrosine were increased. The relative p... | 239,221 | [
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The activity of tyrosine hydroxylase in intact adrenergic neurons of the mouse vas deferens. | A procedure is described for measuring the activity of tyrosine hydroxylase in the intact adrenergic neurons of the mouse vas deferens. In this procedure, the L-dopa-1-14C which is formed from L-tyrosine-1-14C by the action of tyrosine hydroxylase is selectively and quantitatively decarboxylated by endogenous aromatic-... | 239,222 | [
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The absence of renal bicarbonate reabsorption maxima during carbonic anhydrase inhibition. | Present studies were performed to examine the effect of carbonic anhydrase inhibition on bicarbonate reabsorption under experimental conditions where extracellular fluid volume expansion was minimized. The data showed no tubular maximum for bicarbonate reabsorption in the normal state or after carbonic anhydrase inhibi... | 239,223 | [
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Intracellular pH and distribution of weak acids across cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm. | 1. The steady-state distribution ratios of D- and L-lactate between fibre water and external fluid were measured in 'intact' rat hemidiaphragm preparations exposed for 2-5 hr to a variety of solutions of normal ionic strength and osmolarity. The studies were designed to minimize the effects, on these distributions, of ... | 239,228 | [
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Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid. | To determine if the common practice of giving antacids to patients on salicylate therapy has an effect on serum salicylate concentrations, we gave a widely used antacid, aluminum and magnesium hydroxide, and aspirin concomitantly to three children with rheumatic fever. Urinary pH increased appreciably, and serum salic... | 239,345 | [
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Fluid removal with negative-pressure hydrostatic ultrafiltration using a partial vacuum. | Removal of excessive fluid with a negative-pressure hydrostatic ultrafiltration technique using a partial vacuum was performed successfully in eight patients. The technique appears to be a satisfactory means of fluid removal. | 239,356 | [
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The significance of histamine H1 and H2 receptors on the carotid vascular bed in the dog. | Intra-arterial histamine produced a dose-dependent increase in common carotid blood flow due to an active vasodilation. A supramaximal dose of mepyramine (H1-blocker) only partially suppressed the effects of lower doses of histamine without influencing those of its higher amounts. Both metiamide and burimamide (H2-bloc... | 239,368 | [
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Some physical parameters controlling cell size during the evolution of the procaryons. | Possible factors controlling cell size during the evolution of unicellular organisms have been examined. It has been shown that considerations of osmotic and membrane pressure eqilibria will predict minimal cell sizes which are in good agreement with those found in present day microorganisms. It has also been shown tha... | 239,376 | [
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Lactic acid permeation rate in working gastrocnemii of dogs during metabolic alkalosis and acidosis. | In isolated, blood perfused, supramaximally stimulated, isotonically working gastrocnemii of dogs lactic acid (LA) output and O2-consumption (V O2) were measured according to the Fick principle. Simultaneously concentration of muscle tissue was determined at rest and at different times during exercise. In one series of... | 239,385 | [
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0.1234078,
0.04305138,... |
Network analysis of dendritic fields of pyramidal cells in neocortex and Purkinje cells in the cerebellum of the rat. | The connectivity within the dendritic array of Purkinje cells in the cerebellum and pyramidal cells of the neocortex of the rat, stained by the Golgi-Cox method, has been quantified by the method of network analysis. Connectivity was characterized either by applying the system of Strahler ordering, which assigns a rela... | 239,415 | [
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0.2... |
The behavioural final common path. | In this paper it is argued that any model of the motivational (i.e. reversible) processes governing the behaviour of an animal can be represented by means of isoclines in a multidimensional 'causal-factor space'. The argument is axiomatic, based upon the two prime assumptions: that (1) it is always possible to classify... | 239,416 | [
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Influence of the cells on the pericellular environment. The effect of hyaluronic acid on proteoglycan synthesis and secretion by chondrocytes of adult cartilage. | The chondrocyte is a specialized cell that synthesizes proteoglycans of a type found only in cartilage and nucleus pulposus. These proteoglycans are distinct in forming multiple aggregates of unique structure in which hyaluronic acid provides a central chain to which many proteoglycan molecules are bound at one end onl... | 239,423 | [
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The existence during gestation of an immunological buffer zone at the interface between maternal and foetal tissues. | In mammalian pregnancy the trophoblast normally constitutes an uninterrupted boundary of foetal tissue in immediate contact with maternal tissue, including blood in some species, and is the decisive immunological barrier to rejection of the foetus as an allograft. The ability of the trophoblast to function as a barrier... | 239,427 | [
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Binding of tritiated dehydroretronecine to macromolecules. | In vivo and in vitro experiments have shown that the pyrrolizidine alkaloid metabolite dehydroretronecine binds readily to macromolecules. In the in vivo experiment there was a preferential binding of dehydroretronecine to the gastric mucosa. Further extraction of the mucosa revealed a large percentage of the 3H was bo... | 239,444 | [
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0.04977361,
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Gastro-oesophageal acid reflux. Method for 12-hour continuous recording of oesophageal pH with analysis of records. | Description of method for continuous recording of oesophageal pH and automatic, electronic analysis of records. Stability of apparatus has been tested over 12 hours in the laboratory with different buffer solutions and gastric secretions with and without bile, and on 36 patients with oesophageal disorders. Drift of app... | 239,448 | [
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0.068... |
[Tissue compatiblity of stomatologic materials in cell cultures]. | The paper contains results of investigations on the suitability of cell cultures for biological testing of soluble substances from dental cements and their components. The preparation of the specimens as well as the elution process are described. Furthermore the culture system of cell populations in vitro and represent... | 239,500 | [
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[Biolgical problems of a manmade small lake (author's transl)]. | In connection with an intensive hygienic supervision of public bathing facilities and the attempts to draw up a law on bathing hygiene, the lack of contamination standards for small lakes available to the public for bathing was particularly conspicuous. In addition to the current chemical and bacteriological routine ex... | 239,502 | [
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[Pathomorphological and immunofluorescent studies of smallpox vaccine neurotropism]. | Experiments were conducted on guinea pigs sensitized with the AK C-vaccine components. In intracardiac injection with smallpox vaccine there was shown a possibility of development of marked hemodynamic disturbances, of the inflammatory-dystrophic processes of irreversibel character, with a subsequent neuronophagia and ... | 239,507 | [
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Self-association, conformation and binding equilibria of concanavalin A. | The discovery of distinct intact and fragmented forms of Con A, together with the observation that Con A self-associates near neutrality raises questions that may be important when interpreting experiments concerned with the biological actions of the protein. Do intact and fragmented units have the same affinity for ca... | 239,535 | [
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... |
Comparison of methods to study enzyme induction in man. | A combination of several in vivo parameters has been applied in male healthy volunteers to test the suitability of these parameters to indicate enzyme induction in man: Urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol, activity of serum gamma-glut amyltranspeptidase, and pharmacokinetics of aminopyrine r... | 239,546 | [
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Excision of bromodeoxyuridine from T4-DNA by an antimutator polymerase of T4 phage. | With gene-43 (DNA polymerase)-ts-mutants of T4 phage, L98 (mutator) and CB121 (antimutator), and the T4 wild type, double labelling of DNA was carried out with (H3)-bromodeoxyuridine (BUdR) and (C14)-thymidine (TdR). Experiments on (C14) TdR for DNA synthesis measurement in the presence of BUdR offered evidence of the ... | 239,571 | [
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Passive immunity against Junín virus in mice. | Passive immunity, naturally acquired from immune mothers or artificially induced by the administration of homologous hyperimmune serum, conferred on suckling mice a high degree of resistance against infection with Junín virus. Maternal antibodies in the circulating blood of the young were not detectable in the first da... | 239,579 | [
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0.017992... |
Alterations in myocardial hydrogen ion concentration after temporary coronary occlusion: a sign of irreversible cell damage. | Alterations of hydrogen ion (H+) concentration in the myocardium of 60 cats were determined before release of coronary ligation of 30, 45, 60, 90 or 180 minutes' duration, or 5, 30 and 90 minutes after release of the occlusion, by pressing pH indicator paper on unfixed frozen heart sections. The H+ concentration had cl... | 239,588 | [
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... |
Comparison of several activated partial thromboplastin time methods. | Activated partial thromboplastin times (APTT's) performed with a semi-automated electrical-conductivity type of clot timer on plasmas from patients with hepatic disease and intravascular coagulation, and on warfarin or heparin therapy, were significantly lower than when done on the same plasmas with either a manual opt... | 239,589 | [
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0... |
Peritubular pH and PCO'2 in renal tubular acidification. | The influence of peritubular capillary pH and PCO'2 on renal tubular acidification was studied in rats by luminal and peritubular perfusion techniques. Luminal stopped-flow microperfusions were carried out with bicarbonate or alkaline phosphate solutions and luminal pH continuously measured by antimony micorelectrodes... | 239,600 | [
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Influence of mare uterine tubal fluids on the metabolism of stallion sperm. | Three experiments were conducted on the metabolism of stallion sperm. In experiment 1, whole and washed sperm were incubated under aerobic and anaerobic enviroments and analyzed before and after controlled incubation for motility, pH, lactic acid, glucose, fructose, and O2 comsumption. In experiment 2, whole and washed... | 239,615 | [
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The effect of drug therapy without volume restoration in experimental traumatic shock. Part II. Pethidine. | Different opinions seem to exist as to the use of analgesies in the treatment of trauma patients. For this reason we investigated experimentally the effect of pethidine in traumatic shock. Pethidine was administrated to eight of sixteen anaesthetized rabbits with lower limb injuries. The effect of pethidine was unfavou... | 239,623 | [
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0.210516... |
An inducible beta-lactamase in a strain of Escherichia coli. | The production of beta-lactamase (penicillin/cephalosporin beta-lactam amidohydrolase, E.C.3.5.2.6) was found to be inducible in a clinically isolated strain of Escherichia coli. This is the first report of an inducible beta-lactamase in E. coli. The optimal concentration of inducer was 400 mug/ml of ml of benzylpenici... | 239,625 | [
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... |
The occurrence of killer character in yeasts of various genera. | Species of 7 of the 28 yeast genera in the National Collection of Yeast Cultures exhibited killing activity against Saccharomyces cerevisiae. The highest incidence of killer yeasts was found in the genus Hansenula (12 of the 29 strains examined). Saccharomyces, the best represented genus in the Collection, showed a low... | 239,627 | [
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... |
Sympathetic component of the pressor response to angiotensin II in the pithed rat after pretreatment with disulfiram. | Pressor responses to angiotensin II in the pithed rat were unaffected or slightly increased by procedures such as reserpine pretreatment, alpha and beta adrenoceptor blocking agents or bethanidine which inhibit the sympathetic system. Disulfiram-induced inhibition of angiotensin II pressor responses was unaffected by p... | 239,647 | [
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Biologically active substances in oak gall extracts. Part 11. The antihistamine-like activity of a substance (KC-18) isolated from oak gall extracts. | The effects of the newly isolated antihistamine (KC-18) from the Hungarian oak gall extracts on some actions of histamine have been investigated. Intraperitoneally administered KC-18 into guinea pigs and cats in doses of 2.5-16 mg/kg exerted a significant dose-related inhibition of histamine-induced bronchoconstriction... | 239,649 | [
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Comparative study on hydrolases in five species of Ochromonas (chrysomonadina). | Acid phosphatase and beta-glucosidase were shown to be present in five species of Ochromonas grown in organic media (O. danica, O. malhanesis, O. munuta, O. sociabilis and Ochromonas sp. 933/4). Acid phosphatase was found to have a pH optimum at 4.0 in O. danica, and at 5.1 in the four other species. No alkaline phosph... | 239,661 | [
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Interactions of urdine diphosphate glucose dehydrogenase with the inhibitor urdine diphosphate xylose. | 1. UDP-xylose and UDP-glucose both bind to UDP-glucose dehydrogenase in the absence of NAD+, causing an enhancement of protein fluorescence. 2. The binding of UDP-xylose is pH-dependent, tighter binding being observed at pH8.2 than at pH8.7. 3. At low protein concentrations sigmiodal profiles of fluorescence enhancemen... | 239,676 | [
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... |
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions. | 1. The effects of vitamin E deficiency, and of vitamin E and selenium deficiency, on rat liver microsomal aminopyrine demethylase activity were investigated. It was found that, over a wide range of substrate concentrations, the enzyme activity in preparations from deficient animals was significantly lower than that in ... | 239,693 | [
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0.3904237,
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0.03410318,
0.1608238,
0.187372... |
Purification and heterogeneity of inorganic pyrophosphatase of pig scapula cartilage. | Inorganic pyrophosphatase (pyrophosphate phosphohydrolase; EC 3.6.1.1) was purified from pig scapula cartilage by fractionation with N-cetylpyridinium chloride and (NH4)2SO4, followed by ion-exchange and gel-filtration chromatography. Enzyme preparations of high purity were obtained, with specific activities (100-400 u... | 239,695 | [
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0.1654979,
0.3883257,
0.3128666,
0.08405287,
-0.0318362... |
Properties of inorganic pyrophosphatase of pig scapula cartilage. | The properties of a highly purified inorganic pyrophosphatase (pyrophosphate phosphohydrolase; EC 3.6.1.1) from pig scapula cartilage were studied. The enzyme had a molecular weight of 66 000 and a pH optimum of 7-8. It was markedly activated by magnesium, but not, or only to a much smaller degree, by other metal ions.... | 239,696 | [
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0.00229914,
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-0.4473278,
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0.1077586,
0.336155,
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0.04174661,
0.0322099,
0.1807574,
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0.1725542,
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0.6808273,
0.3301668,
0.1421872,
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0.2... |
The formation of mono-N-acetylhexosamine derivatives of dolichol diphosphate by pig liver microsomal fractions. | Incubation of pig liver microsomal preparations with UDP-N[U-14C]acetylglucosamine yields a 14C-labelled lipid. The requirement for Mn2+, the pH optimum, time-dependence and the reversibility by UMP of the transferase are reported. Evidence is presented in favour of the lipid being a mixture of dolichol diphosphate N-[... | 239,708 | [
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0.2911676,
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Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. | The pharmacological properties of seven pure saponins isolated from Panax ginseng C. A. Meyer were studied. 1. The ginseng saponins showed weak toxicities in mice. Especially, Rg1, Rf and Rb 1, which contained glucose as a sugar component, were weaker in their toxicities than the rest, which contained arabinose and/or ... | 239,732 | [
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0.1664612,
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The role of pH in the regulation of carbon fixation in the chloroplast stroma. Studies on CO2 fixation in the light and dark. | 1. The pH in the stroma and in the thylakoid space has been measured in a number of chloroplast preparations in the dark and in the light at 20 degrees C. Illumination causes a decrease of the pH in the thylakoid space by 1.5 and an increase of the pH in the stroma by almost 1 pH unit. 2. CO2 fixation is shown to be st... | 239,746 | [
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0.3375337,
0.08332139,
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Interaction of transition metal ions with ribonuclease A. II. The selective effects of Mn2+, Zn2+, Cd2+ and Hg2+ on the histidine magnetic resonance. | Zn2+, Cd2+ and Hg2+ inhibit ribonuclease but Mn2+ does not except at very high concentrations. By high resolution NMR one can detect in the pH range 5-8 the C-2 protons of histidines 105, 12, and 119. The inhibiting ions produce large shifts of the resonance of His-12 but not of His-105. On the other hand Mn2+ broadens... | 239,749 | [
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[Hemoglobin oxygen transport during experimental acute hypercapnia (author's transl)]. | The effects on hemoglobin oxygen transport of acute respiratory acidosis have been studied in dogs inhaling a gaseous mixture with 12% CO2 (O2 21%) for two to five hours. In a first series of experiments, it was shown that the shape of the oxyhemoglobin dissociation curve (ODC) was not modified by severe acidosis (pH c... | 239,780 | [
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0.07460089,
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Studies of suspected neurotransmitters in the vestibuloocular pathways. | Isolated fresh cat trochlear and oculomotor nuclei, which contain the axon terminals of inhibitory neurons whose cell bodies are in the superior vestibular nucleus (SVN), actively synthesize and store [3H]GABA, [14C]acetylcholine, [3H]dopamine and [3H]tyramine from labeled precursors of these compounds. Twelve to 14 da... | 239,786 | [
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0.1376943,
0.2685891,
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... |
Precipitation of calcium phosphates from electrolyte solutions. III. Radiometric studies of the kinetics of precipitation and aging of calcium phosphates. | Precipitation and precipitate transformation in the system sodium phosphate (pre-adjusted to pH 7.4)--calcium chloride (25 degrees) was studied by means of radiometric analysis using 45Ca and 32P as tracers. Changes in the pH and the total concentrations of calcium and phosphate were followed during solid phase format... | 239,787 | [
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0.6040797,
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0.07313967,
... |
Human erythrocyte glucose 6-phosphate dehydrogenase. Influence of coenzyme derivatives on thermostability and kinetic properties. | A number of derivatives of NADP(H) were tested with respect to their effectiveness in interacting with tetrameric glucose 6-phosphate dehydrogenase (G6PD) retaining only the fraction of "structural" coenzyme (4 moles NADP). Interaction was probed by two parameters: a) increased thermostability of G6PD activity, measure... | 239,915 | [
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0.005383561,
0... |
Regulation of glutaminase levels in Escherichia coli. | Nitrogenous metabolites, cyclic adenosine 3':5'-monophosphate (cAMP), and the stage of culture growth all influence the levels of glutaminase A in Escherichia coli, but no variables in culture conditions alter the levels of glutaminase B. Growth of E. coli on culture media containing glucose and excess ammonia results ... | 239,927 | [
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0.4087558,
0.3717342,
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... |
Molecular aspects of the inactivation of tryptophanyl transfer ribonucleic acid synthetase by N-ethylmaleimide. | The tryptic maps of tryptophanyl-tRNA synthetase from beef pancreas show that the 8 cysteinyl residues of the enzyme subunit are located, 2 by 2, on four different peptides. The kinetics of the incorporation of radioactivity from N-[ethyl-14C]ethylmaleimide into these peptides are compared in this paper with the kineti... | 239,947 | [
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0.2705593,
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Use of L-rhamnose to study irreversible adsorption of bacteriophage PL-1 to a strain of Lactobacillus casei. | L-rhamnose has been found to be useful to investigate the process of irreversible adsorption of PL-I phage to its host bacterium, Lactobacillus casei ATCC27092. L-rhamnose inhibited phage adsorption to cells without inactivating free phages. Adsorption inhibition was correlated with the concentrations of L-rhamnose. Th... | 239,994 | [
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0.3885083,
0.1599459,
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Effects of undernutrition and protein malnutrition on brain chemistry of rats. | The present study was undertaken to assess the effects of different degrees of nutritional restrictions during fetal life, suckling, and after weaning on the chemical composition of the brain. At 42 days of age, the rats were killed, and the brains were processed for analyses. The rats exposed to severe protein malnutr... | 240,010 | [
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0.2790569,
0.2526405,
... |
Potential histamine H2-receptor antagonists. 2. N-alpha-Guanylhistamine. | The agonist molecule, histamine, has been used as a starting point for the design of potential H2-receptor antagonists. Converting the side-chain amino group into a guanidine yielded the first histamine H2-receptor antagonist, Nalpha-guanylhistamine. Antagonism of H2 receptors was demonstrated by the inhibition of hist... | 240,023 | [
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0.03632828,
0.2210018,
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0.127... |
Potential inhibitors of L-asparagine biosynthesis. 3. Aromatic sulfonyl fluoride analogs of L-asparagine and L-glutamine. | The N-[p-(fluorosulfonyl)benzyl] derivatives of L-asparagine and L-glutamine (1a,b) were synthesized as potential inhibitors of L-asparagine synthetase (ASase). Condensation of p-(fluorosulfonyl)benzylamine (2) with the suitably protected amino acid in the presence of dicyclohexylcarbodiimide, followed by deblocking, a... | 240,024 | [
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0.4482447,
0.3618895,
0.09253863,
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0.3570... |
Utilization of supervised physician's assistants in emergency room coverage in a small rural community hospital. | A study has been made of an initial 2-year experience in a 90-bed rural community hospital where emergency room primary coverage has been provided by Physician's Assistants under supervision of specialists in the field of general surgery, pediatrics, and internal medicine. Emphasis has been placed on a rigidly supervis... | 240,036 | [
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0.130157,
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0.03361026,
0.030941... |
Studies of introital colonization in women with recurrent urinary infections. II. A comparison of growth in normal vaginal fluid of common versus uncommon serogroups of Escherichia coli. | Vaginal fluid collected from volunteers who denied a history of urinary infections was bactericidal to Escherichia coli at pH 4.0. When the pH was increased to 6.5 with sodium hydroxide, the same vaginal fluids supported bacterial growth. If vaginal fluid was adjusted at pH increments between 4.0 and 5.0, and inoculate... | 240,039 | [
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0.07460111,
0.2889834,
0.04855059... |
[Possibilities of treatment of arthrogryposis]. | The results of the treatment of 90 patients with arthrogryposis are resumed. The possibilities of the conservative treatment are discussed and on the basis of their experiences and the data of the literature the details of the surgical technique are given for each articulation. Besides conservative therapy 86 different... | 240,084 | [
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Cholesterol metabolism by Mycobacterium. | Cholesterol metabolism by Mycobacterium species ATCC Number 19652 was studied in defined media. Whole cells were found to take up 91% of the total cholesterol when incubated five days at 34 degrees C in media of pH 6.8-7.4. Uptake of cholesterol by whole cells could be significantly inhibited by 2,4-dinitrophenol and d... | 240,103 | [
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0.1999335,
0.1548974,
0.1748558,
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0.1... |
Correlation between plasma levels of prolactin and chlorpromazine in psychiatric patients. | Plasma levels of chlorpromazine (CPZ) and prolactin were measured repeatedly in 14 psychiatric patients throughout CPZ treatment. Mean prolactin level was elevated in 11 subjects (all six women and five of eight men). Mean plasma prolactin correlated significantly with mean plasma CPZ but not with the dose of the dru... | 240,179 | [
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0.3383776,
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Auditory signal detectability and facilitation of simple reaction time in psychiatric patients and non-patients. | Patients diagnosed on the basis of structured interviews as having affective psychoses were less sensitive in detecting the presence of a transient auditory signal than were schizophrenic patients or non-patients. Patients with affective psychoses also benefited more (their reaction time was more reduced) than the othe... | 240,180 | [
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Work in progress. Occurence of phospholipase A1 and A2 in human decidua. | Phospholipase A2, an enzyme which may regulate the formation of polyunsaturated fatty acids utilized for prostaglandin synthesis, was found to have significant higher activity in decidual than in myometrial tissue. The major part of phospholipase A2 in the decidua had an acid pH optimum, which indicates that most of th... | 240,188 | [
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0.1983268,
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Prostaglandin synthetase activity from human rheumatoid synovial tissue and its inhibition by non-steroidal anti-inflammatory drugs. | 1. Prostaglandin synthetase activity was found in a microsomal fraction from human rheumatoid synovia. 2. The microsomes produced PGE2 and a small amount of PGF2 when incubated with arachidonic acid. 3. The pH optimum of the enzyme from this source was similar to that found with microsomal preparations from rabbit rena... | 240,190 | [
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0.2143626,
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[Acquired ulcero-mutilating acropathies in adults. Critical study of 150 personal cases]. | The authors review critically a series of cases, followed up by the authors, of acrodynia and trophic ulcers occurring either in alcoholics (119 cases) or in diabetics (28 cases), who were also often alcoholic as well. The symptoms were similar in both groups. However, the poor nutrition was generally more market in th... | 240,201 | [
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0.156142,
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0.05112122,
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0.1303891,
0.1179053,
... |
Hepatitis B (surface) antigen in mothers and their infants. | Hepatitis B (surface) antigen (HBSAg) was found in the serum of 8 out of 4 245 women attending the antenatal clinic of the Queen Victoria Maternity Hospital Seven (0, 16%) were asymptomatic carriers of the antigen, while the eigth suffered from polyarteritis nodosa. Seven of the 8 babies born to these mothers were foll... | 240,207 | [
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0.1106699,
0.3586119,
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Resistance of the Candida albicans filamentous cycle to environmental change. | The filamentous growth cycle in C. albicans was resistant to changes in environment brought about either by the serial transfer of growing cells to fresh nutrients or by sudden changes of temperature after the first h of growth. In further experiments older culture filtrates, exhausted of their ability to induce myceli... | 240,208 | [
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... |
Hemodynamics and blood flow distribution following prolonged circulation at 5 degrees C. | Circulation was maintained in profoundly hypothermic dogs for 8 h at temperatures below 10 degrees C. During cooling to 5 degrees C cardiac output and blood pressure decreased and peripheral resistance rose. Thereafter, circulatory dynamics remained relatively stable over the next 6 h with a gradual decline in blood pr... | 240,278 | [
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... |
[Age dependence and stimulation of renal excretion of trishydroxymethylaminomethane (Tham)]. | In rats of different age (5 to 240 days old) the renal excretion of Trishydroxymethylaminomethane (THAM) was studied. In 5 and in 240 days old rats the renal excretion of THAM was slower than in rats of other age groups. Stimulation of diuresis by i.p. injection of mannitol, thiazide or by oral water load resulted in a... | 240,333 | [
-0.2614327,
-0.2685108,
-0.3597749,
-0.08733909,
0.1551752,
-0.5225964,
-0.3419452,
-0.0463071,
-0.2634654,
0.0008093701,
-0.06230842,
0.1889586,
0.2305555,
-0.169924,
-0.7676932,
-0.0755148,
-0.021755,
0.2471445,
-0.3934555,
0.3441303,
0.4798687,
0.3462159,
-0.09866415,
... |
Should tonometry screening be done by technicians instead of physicians? | A random sample of 768 clinic patients 40 years or older were screened by a technician utilizing Schlotz tonometry. All patients with an intraocular pressure of 20 mm Hg or more were referred for ophthalmological evaluation. The prevalence of frank glaucoma and suspected glaucoma in this infirm population was 1.8% and ... | 240,334 | [
0.06798702,
0.08216578,
-0.1754823,
0.05581908,
0.1925096,
-0.1995948,
-0.3292721,
0.02436142,
0.3621748,
-0.1636338,
0.07971855,
-0.01305121,
-0.2050325,
-0.3057334,
-0.1019267,
0.09386587,
-0.3860768,
0.1379964,
-0.2020357,
0.005023091,
-0.00325103,
0.1597214,
0.1791326... |
The rectal administration of lactulose. | A lactulose colonic washout (pH 4.5) was administered to six male patients with portal systemic encephalopathy. Estimation of blood ammonia levels and electroencephalography were performed before and after each treatment. Five patients recorded a significant fall in blood ammonia level as a result of lactulose therap... | 240,347 | [
-0.274095,
0.07122786,
-0.1958258,
-0.1234313,
-0.01007194,
-0.2930058,
-0.3908483,
-0.365628,
-0.2641439,
-0.2886548,
0.07537178,
-0.07179649,
0.07007939,
-0.0233735,
-0.2623322,
-0.005242995,
-0.3198693,
0.1877244,
-0.1386884,
-0.1539882,
-0.1415196,
0.2268379,
0.297304... |
Correlation proton magnetic resonance studies at 250 MHz of bovine pancreatic ribonuclease. I. Reinvestigation of the histidine peak assignments. | The deuterium exchange kinetics of the C(2) protons of the four histidine residues of native bovine pancreatic ribonuclease A have been followed at pH 6.5 and 8.0 by proton magnetic resonance spectroscopy (1H NMR). Comparison of the order of exchange of the histidine peaks with tritium exchange rates into individual hi... | 240,382 | [
-0.1245141,
-0.2248734,
0.01626262,
-0.03302346,
-0.01902618,
-0.2653383,
0.1463115,
0.009361661,
0.07829609,
0.0658496,
0.1780514,
0.03728632,
-0.06286395,
-0.01650162,
-0.258205,
-0.1597333,
-0.06977273,
-0.1001324,
0.08430634,
-0.01793792,
0.159191,
0.08957047,
0.02564... |
Isolation and characterization of papaya peptidase A from commercial chymopapain. | Chromatography on a column of SP-Sephadex shows that commercial chymopapain contains three components with proteolytic activity. Each behaves as a single protein upon rechromatography and electrophoresis on polyacrylamide gels. The major component, which represents 31% of the activity applied to the column and is the m... | 240,390 | [
0.06283746,
-0.07180385,
0.003952936,
-0.0261674,
0.000353603,
-0.02592891,
-0.08684307,
-0.2821139,
0.2075181,
0.2551722,
0.1148068,
0.08231808,
-0.06045906,
-0.1047362,
0.0378093,
0.2773046,
-0.6146144,
-0.05595077,
0.2844353,
0.2089412,
0.2169081,
0.1000502,
0.05668757... |
Enolase catalyzed beta,gamma-alpha,beta isomerization of 2-phospho-3-butenoic acid to (Z)-phosphoenol-alpha-ketobutyrate. | 2-Phospho-3-butenoic acid was synthesized and found to be a substrate for both yeast and rabbit muscle enolase (EC 4.2.1.11). Enolase catalyzes the isomerization of 2-phospho-3-butenoic acid to (Z)-phosphoenol-alpha-ketobutyrate, a beta,gamma-alpha,beta isomerization. Nuclear magnetic resonance studies on the product i... | 240,397 | [
-0.2338068,
0.1336768,
-0.3039074,
-0.0731582,
0.1220788,
0.1565612,
-0.1216739,
0.2544269,
0.005380691,
-0.05321243,
0.122283,
-0.05535349,
0.228849,
-0.1120004,
-0.46573,
0.04998795,
-0.7850404,
0.1347847,
0.2500925,
0.2260806,
0.1986878,
0.334242,
-0.05128431,
0.0198... |
Studies of homogeneous "biosynthetic" L-threonine dehydratase from Escherichia coli K-12. Some kinetic properties and molecular multiplicity. | "Biosynthetic" L-threonine dehydratase (EC 4.2.1.16) was purified to a homogeneous state with 29% yield of total activity from Escherichia coli K-12. The homogeneity of the enzyme was shown by polyacrylamide gel disc electrophoresis in the presence of dodecyl sulphate. The enzyme consisted of equal subunits having a mo... | 240,428 | [
-0.03791443,
0.08293489,
-0.06749497,
0.02216011,
0.009194272,
-0.6787753,
-0.06104574,
0.1733968,
0.02705206,
-0.03253238,
0.02374835,
-0.07942674,
-0.08765075,
0.2652719,
-0.3868049,
0.110511,
-0.5026346,
0.0991552,
0.5346695,
0.154957,
0.719531,
0.3633026,
-0.4653457,
... |
Improvement in prognosis of myocardial infarction by long-term beta-adrenoreceptor blockade using practolol. A multicentre international study. | In a large-scale double-blind controlled trial of practolol (200 mg twice daily) in the long-term prophylactic treatment of 3038 patients recovering from acute myocardial infarction treatment was started one to four weeks after the acute attack. The trial was originally planned to include 4000 patients treated for at l... | 240,481 | [
-0.03564769,
-0.2769794,
-0.2755511,
-0.5405948,
-0.08579051,
-0.3564239,
-0.2875464,
-0.2096032,
0.1923312,
-0.3871356,
-0.2960747,
0.07091458,
0.02763482,
0.04962865,
-0.04275492,
-0.05077849,
-0.4483961,
0.07042137,
-0.1088326,
0.3232441,
0.1905856,
0.2852592,
-0.34450... |
[Specificity of action of phospholipases of rat intestinal mucosa]. | The total homogenate of rat intestine is devoid of C or D phospholipase activity. At pH 6,5 in the presence of phosphatidylcholines, it exhibits a B phospholipase activity and in the presence of exogen lysophosphatidylcholines an A1 lysophospholipase activity. At pH 8,5 the intestinal mucous membrane of a rat shows an ... | 240,509 | [
-0.04741858,
-0.4629436,
-0.06316277,
0.03037119,
0.1962246,
-0.05811696,
-0.3707811,
0.0432313,
-0.01177491,
-0.2202907,
0.0589664,
0.08478919,
0.1503823,
-0.08072723,
-0.5222455,
-0.2145455,
-0.625461,
-0.01412933,
0.1761893,
0.2031456,
0.3438169,
0.1744956,
-0.1446187,... |
Isoelectrofocusing in acetate membrane: the method and application. | Acetate membrane as a new medium for isoelectrofocusing was used in this study. The acetate membrane was specially produced for isoelectrofocusing, and contains a surface active agent. The ampholine solution system and isoelectric condition for this purpose are described. Polymorphic traits as alpha1-antitrypsin in hum... | 240,520 | [
-0.3941259,
-0.1827832,
-0.297244,
0.2593348,
-0.0501323,
-0.09117056,
-0.2953276,
0.1504868,
-0.02698133,
-0.03912623,
0.2489706,
0.2219965,
0.1365972,
0.4290037,
-0.2203926,
-0.1998944,
-0.511833,
-0.2078469,
-0.2498432,
0.1182155,
0.4279905,
0.1142,
-0.1913973,
-0.06... |
Studies on the carrier state in X-linked recessive (Duchenne) muscular dystrophy. | Observations in 12 normal women and 12 female carriers of X-linked recessive Duchenne muscular dystrophy (DMD), of whom 4 had symptoms and 8 had none, were compared between all 4 groups and with those in 2 DMD boys, one active and one crippled. Carrier symptoms were readily ascertained by systematic examination. Measur... | 240,524 | [
-0.3355761,
0.04553323,
-0.1752993,
-0.02919459,
-0.0855073,
-0.4156193,
-0.1962677,
-0.1147108,
-0.08640958,
-0.1468429,
0.1338713,
0.2748424,
0.167564,
0.3550964,
-0.4871637,
-0.03596578,
-0.4861792,
-0.1629428,
-0.2560571,
0.05696763,
0.1948894,
0.1192984,
-0.01356593,... |
Failure of adrenergic alpha and beta receptor blockade to elevate the TSH and prolactin response to TRH in hyperthyroidism. | The effects of adrenergic alpha and beta receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hy... | 240,525 | [
0.05412029,
-0.2769669,
-0.5085279,
-0.4271387,
0.07552736,
-0.2883951,
0.06565929,
-0.214194,
-0.3069035,
0.07160653,
0.07296047,
0.7002969,
0.03048565,
0.282347,
0.04024906,
-0.1551468,
-0.501709,
0.1828083,
-0.02099438,
-0.3218501,
0.2316167,
0.4433686,
0.0824232,
0.... |
Optimum pH for nuclear sex identification using quinacrine. | Preparations of quinacrine stained interphase nuclei from buccal smears and hair root sheaths were mounted in MacIlvaine's buffer at various pH's in an attempt to obtain optimum differentiation of X- and Y-chromatin. Relatively high pH (5-8) was associated with intense nuclear fluorescence. Background nuclear fluoresce... | 240,526 | [
0.1646128,
0.1258914,
-0.1444043,
-0.1231998,
-0.1160594,
-0.1187448,
-0.1721332,
-0.002831829,
0.01250556,
-0.227885,
-0.1625144,
0.310427,
0.2995718,
0.6834391,
-0.6248072,
-0.5608375,
-0.3403026,
-0.2009738,
-0.1465697,
-0.1003298,
0.6613553,
0.03776131,
-0.03029814,
... |
Quantitative analysis of mixed association between different protein molecules. Physico-chemical and enzymatic properties of rat-liver glutamate dehydrogenase. | The theoretical and experimental analysis of a reversible association-dissociation equilibrium between different proteins (mixed association) is described. The experiments were performed with glutamate dehydrogenases from beef and rat liver. These enzymes are different, especially with respect to their association beha... | 240,677 | [
0.1095868,
0.1676123,
-0.2235643,
0.2921926,
0.0996328,
-0.4103011,
-0.2425531,
0.05549283,
0.01855588,
0.2572243,
0.1553076,
0.07690477,
0.07362647,
0.2228858,
-0.4801515,
0.3477693,
-0.6368911,
0.1037057,
0.04311898,
0.2639856,
0.2124465,
-0.02759281,
0.06982367,
0.21... |
The stimulation of liver phosphorylase b by AMP, fluoride and sulfate. A technical note on the specific determination of the a and b forms of liver glycogen phosphorylase. | 1. The activity of liver phosphorylase b from several mammalian species has been studied. The enzyme from rat or mouse has a higher activity than the rabbit enzyme, which is itself more active than pig liver phosphorylase b. 2 The activity of liver phosphorylase b is influenced by anions and by AMP, and these effects a... | 240,685 | [
-0.2787115,
-0.08153006,
-0.4524329,
0.1201412,
0.1830914,
-0.06006347,
-0.1076678,
0.2679595,
-0.2039973,
-0.1534534,
-0.1158639,
-0.0845388,
0.2158699,
0.03708627,
-0.3602184,
-0.1686115,
-0.2190458,
-0.04298645,
-0.1029123,
0.5547472,
0.4263294,
0.04542865,
-0.1520879,... |
D-alanine carboxypeptidase activity of Micrococcus lysodeikticus released into the protoplasting medium. | Conversion of whole cells of Micrococcus lysodeikticus to protoplasts allowed the release of a soluble form of a D-alanine carboxypeptidase into the protoplasting medium. The enzyme cleaves the terminal D-alanine from the radioactively labelled UDP-N-acetylmuramyl-pentapeptide containing L-lysine as the diamino acid. H... | 240,694 | [
0.09963769,
-0.2819129,
-0.1507384,
0.1426044,
-0.0139686,
-0.280082,
-0.05277743,
0.3448786,
-0.05629081,
0.01605783,
0.254179,
0.03609739,
0.001264396,
0.2037252,
-0.306827,
0.3576878,
-0.4722942,
0.1965379,
-0.2110517,
0.2753778,
0.7921208,
-0.1565639,
-0.07425901,
-... |
Enzymic synthesis of an aromatic ring from acetate units. Partial purification and some properties of flavanone synthase from cell-suspension cultures of Petroselinum hortense. | Flavanone synthase was isolated and purified about 300-fold from fermenter-grown, light-induced cell suspension cultures of Petroselinum hortense. The enzyme catalyzed the formation of the flavanone naringenin from p-coumaroyl-CoA and malonyl-CoA. Trapping experiments with an enzyme preparation, which was free of chalc... | 240,705 | [
-0.1473854,
-0.01918902,
0.06147389,
0.2494156,
0.1884326,
-0.04684251,
-0.1454563,
0.3095775,
0.1621611,
-0.05598813,
0.007441462,
0.1410903,
0.1002919,
-0.119892,
-0.5509184,
0.3187022,
-0.2566051,
0.3152857,
-0.0827809,
0.6276773,
0.4938453,
0.09760574,
-0.3214633,
-... |
Hydrogen-exchange study of the conformational stability of human carbonic-anhydrase B and its metallocomplexes. | In the range of pH 4.6--8.8, 25 degrees C, the apoenzyme of carbonic anhydrase B shows no evidence of any gross conformational changes, as studied by the hydrogen-deuterium exchange method. At pH 4.6 the addition of Co(II), Cd(II) or Mn(II) to the apoenzyme results in a destabilization of the native protein conformatio... | 240,709 | [
-0.3598316,
-0.03882264,
-0.3593544,
0.3525469,
-0.04703558,
-0.3902704,
-0.2692774,
0.1760281,
-0.03303832,
0.08994449,
0.004453852,
0.04754619,
0.08622567,
-0.1745023,
-0.2782349,
-0.153009,
-0.3193728,
0.2133887,
-0.212314,
0.2482173,
0.2019672,
0.2406624,
-0.06530952,... |
Intracellular distribution of neutral proteinases and inhibitors in pig leucocytes. Isolation of two inhibitors of neutral proteinases. | Granule and post-granular-supernatant fractions were obtained from pig leucocyte cells by differential centrifugation in 0.34 M sucrose. Granule extract possesses proteinase activity at acid and at neutral pH. Three groups of neutral and a group of acid proteinases were isolated from granule extracts by chromatography ... | 240,715 | [
0.07137389,
0.1269121,
-0.1473026,
-0.3890969,
0.06040809,
0.03033859,
0.1693359,
-0.09488887,
0.0466041,
0.04604889,
-0.2328504,
0.1623905,
0.09086292,
-0.2194712,
-0.211561,
0.3925462,
-0.09848095,
0.02699404,
0.3284843,
0.3999853,
0.2759768,
0.211423,
-0.226025,
0.00... |
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