title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Vincristine, prednisone and L-asparaginase in the induction of remission in children with acute lymphoblastic leukemia following relapse. | Two hundred and twenty-seven children with recurrent acute lymphoblastic leukemia were treated with various combinations of vincristine, prednisone, cyclophosphamide and L-asparaginase in an approach to the induction of remission. The combination of L-asparaginase 1,000 mu/kg iv q.d. x 10, vincristine 2.0 mg/m2iv q.w. ... | 272,945 | [
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Use of sequential analysis in clinical trials of caries prophylactic agents. | Using a sequential t test, the objectives of two 3-year experimental clinical trials were achieved more efficiently by using fewer subjects over a shorter time. The assumption of identical distributions of each batch of data analyzed was not apparent and further work to establish the robustness of sequential t tests is... | 273,021 | [
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Movement of the proximal and distal segments after mandibular ramus osteotomies. | Data was collected from 27 patients who were treated with various ramal surgical procedures. Movements of the proximal segment during and after surgery were frequently noted. If the proximal segment was moved from its preoperative position and fixed to the distal segment, occlusal relapse was visible shortly after rele... | 273,072 | [
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Diagnosis of pheochromocytoma during treatment of a mandibular fracture: report of case. | A case of pheochromocytoma, which was discovered during the patient's admission for treatment of mandibular fracture, is presented. Pheochromocytoma represents a potentially life-threatening disease, but alsl is a curable cause of hypertension. Therefore, in spite of its low incidence, it is important that the oral sur... | 273,077 | [
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Lymphosarcoma with lymphoblastic leukemia in a New Zealand white rabbit. | An 8 to 10-week-old female New Zealand white rabbit, Oryctolagus cuniculus, which exhibited clinical signs of anorexia, depression, and torticollis was found to have lymphosarcoma with lymphoblastic leukemia. The multiple visceral involvement with neoplastic lymphoid cells observed in this animal was similar to previou... | 273,119 | [
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The miniaturized x-ray machines in dentistry: structural integrity and safety of the extended-anode tubes. | Two different designs of the extended-anode x-ray tube were evaluated for structural stability and safety. Force-deflection curves were determined in bending and compression modes. Although the tubes experienced similar deflection characteristics, one demonstrated several design advantages. Both machines were judged ad... | 273,195 | [
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Preferential transcription of the ovalbumin gene in isolated hen oviduct nuclei by RNA polymerase B. | The synthesis of ovalbumin mRNA sequences was studied in isolated nuclei from hen oviduct. Two different methods of analysis were used to distinguish in vitro synthesized from preexisting mRNA sequences: (i) Mercurated ribonucleotides were used for in vitro RNA synthesis, and the newly synthesized RNA was purified by c... | 273,231 | [
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Chromatin structure in the cellular slime mold Dictyostelium discoideum. | The structure of Dictyostelium discoideum chromatin has been studied by the following techniques: electron microscopy, staphylococcal nuclease digestion, acrylamide gel electrophoresis, sucrose gradient centrifugation, and melting. The basic unit of chromatin is the nucleosome, which is a particle 98.6 A in diameter. A... | 273,233 | [
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Histone synthesis and differentiation in murine virus-infected erythroleukemia cells. | The murine virus-infected erythroleukemia cells (MELC) has been used as a useful tool to examine the regulatory mechanism of the cytodifferentiation by the genetic approach. Addition of dimethylsulfoxide (DMSO) to the MELC culture induces erythroid differentiation. A study was made to assess whether stimulation of hist... | 273,318 | [
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[Tooth mobility in several age groups with reference to various periodontal diagnostic aspects]. | The present study deals with a study of the tooth mobility, the pocket depth and the bone destruction in 616 periodontally healthy subjects. It was found that the mobility of the upper lateral incisor is inferior to that of the central one. Furthermore, relations of age to tooth mobility and bone destruction were estab... | 273,322 | [
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[The effect of local anesthetics and injuries on the angiographic picture of the cat mandibular blood vessels]. | The authors examined the effects of local anesthetics and traumata (traumatic dental extractions) on the angiographic picture of the mandibular vessels of the cat in the 10th, 70th and 120th minutes. The application of local anaesthetics results in a reduced filling of the inferior alveolar artery in the 10th and 70th ... | 273,324 | [
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[Morphological and histoenzymatic characteristics of the bone marrow in the blastic crisis of chronic myeloleukosis]. | Morphological and histoenzymatic characteristics of bone marrow in blastic crisis of chronic myeloleukemia are presented. Its involvement is proved to be irregular even within the limits of small topographic zones. The later is of importance in establishing the diagnosis of the disease by trepine biopsies in hematologi... | 273,347 | [
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Penetration of ions from silicate cement restorations into Copalite--covered cavity walls. | This study aimed to asses the effect of silicate cement on Copalite -covered cavity walls in extracted human teeth. Class V cavities were prepared in 24 premolars and filled with silicate cement (Bio-Trey). Four cavities were unlined, the rest of the cavities were lined with 1 or 2 layers of Copalite before insertion o... | 273,363 | [
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Hyperthermia and cancer. | The effects of heat and its possible significance in cance therapy have been documented for more than a century. Hyperthermia has been widely investigated as an alternative or adjuvant to conventional therapies such as surgery, radiation, and chemotherapy. The clinical reports are interesting, notwithstanding some harm... | 273,399 | [
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A simplified kidney preservation system: the use of hyperosmolar perfusates for continuous perfusion preservation of canine kidneys. | Since the quality of renal preservation following simple ice storage is improved by the use of hyperosmolar washout solutions, hyperosmolar perfusates were evaluated for continuous perfusion preservation. Canine kidneys were preserved for 48 hours by continuous perfusion at 5 degrees C, using hyperosmolar cryoprecipita... | 273,414 | [
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A portable, low cost ventilation system for transportation of patients with severe acute respiratory failure. | As part of the development of a life support stretcher for transportation of critically ill patients, a portable ventilation system was developed. This system was used successfully during transportation of 6 of 11 patients who required ventilatory assistance and who were being considered for extracorporeal membrane oxy... | 273,498 | [
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Human pulpal response to citric acid cavity cleanser. | Treatment of cavities with citric acid cavity cleanser, also used as an etchant, before restoration with zinc oxide-eugenol cement, was toxic to the human dental pulp in comparison to sham-treated controls. The cleanser caused a significantly (P less than .01) greater intensity and incidence (P less than .01) of inflam... | 273,636 | [
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Sliding osteotomy in the mandibular body for correction of prognathism. | To overcome some of the disadvantages of the mandibular body ostectomy, a sliding osteotomy accomplished by parallel sectionings of the mandible in the regions of the first premolars was used for the treatment of mandibular prognathism in two cases. The osteotomy was performed by an intraoral approach without any damag... | 273,666 | [
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Subacute ectopic pregnancy. | A series of 90 patients with 98 ectopic pregnancies is discussed, emphasising problems of diagnosis. Predisposing factors and evidence of previous pelvic pathology were not uncommon. Laparotomy was considerably delayed in 31 patients, 15 of whom required two admissions before definitive treatment. There was one death i... | 273,791 | [
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Sjögren's syndrome (sicca complex). | A case of sicca complex Sjögren's syndrome in a 41-year-old woman is presented. Symptoms related to xerophthalmia and xerostomia were severe but, ironically, served to confuse the clinical impressions of medical personnel managing this patient, resulting in a diagnostic dilemma. Biopsy of a labial minor salivary gland ... | 273,851 | [
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Kinetics of biphasic reconstitution of tobacco mosaic virus in vitro. | The kinetics of the in vitro reconstitution of tobacco mosaic virus from its RNA and protein were studied by measuring the increase in turbidity, the development of ribonuclease-resistant infectivity, the emcapsidation of the terminal ends of the RNA, and the growth of rod length. The results showed that the reconstitu... | 273,903 | [
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Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells. | Calcium-dependent regulator protein is a low molecular weight (17,000), thermostable, calcium binding protein which is structurally homologous to skeletal muscle troponin C. This protein is present in all nonmuscle cells and has been shown to decorate stress fibers in interphase cells by indirect immunofluorescence. Us... | 273,915 | [
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Antigens of human trophoblasts: a working hypothesis for their role in normal and abnormal pregnancies. | This report describes the preparation and characterization of antisera to human trophoblast membranes. Rabbit antisera were raised to trophoblast microvilli prepared by differential ultracentrifugation. Antibodies to serum proteins were removed by solid-phase immunoabsorption with normal human serum, and indirect immun... | 273,921 | [
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Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). | The mechanism by which negatively charged substances such as celite, kaolin, or ellagic acid contribute to the surface-dependent activation of Hageman factor (Factor XII) was studied. Kinetic studies of the proteolytic activation of (125)I-labeled human Hageman factor by human plasma kallikrein, plasma, activated Facto... | 273,926 | [
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Conjunctival melanocytic lesions. Natural history. | Conjunctival melanocytes are like those of the skin and benign and malignant lesions composed of conjuctival melanocytes act much like those of skin. Conjunctival naevi are common and usually benign. Conjunctival melanomas are rare and arise de novo, from pre-existing junctional naevi or from intraepithelial melanomas ... | 273,993 | [
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The specificity of multi-column liquid chromatography of neutral urinary steroids as evaluated by comparison with parallel gas chromatography and mass spectrometry. | The use of gas chromatography/mass spectrometry is advocated as the best currently available methodology for the validation of a routine assay for steroid analysis. This is documented by comparative studies by gas chromatography/mass spectrometry and spectrophotometry of peak material obtained in routine assays by mult... | 274,042 | [
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Quality control measures in the assay of common urinary steroids as applied to a multi-column chromatographic procedure. | Quality control measures in the assay of common urinary steroids include stringent controls not only with details of the procedure but also, through a steady monitoring of the output, with the use of "blind" duplicates, the application of estimates of duplicate variability, comparison of the sum of individual steroids ... | 274,043 | [
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Circumvallate placenta and intrauterine growth retardation. | A study has been made of a prospectively selected material of circumvallate placentae; the latter being defined as an elevated edge of more than 50% of the circumference. The material consists of 447 placentae from liveborn singleton infants, where 287 were from exemplary pregnancies, and 160 from births with a gestati... | 274,056 | [
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0.1501902,
-0.09904246,
... |
Heavy trace elements in ancient Norwegian teeth. | The present work was undertaken in order to determine the content of lead, cadmium, copper and zinc in 26 teeth retrieved from burial-grounds in various parts of Norway, dated from A.D. 200 up to 1850. The analyses were made by differential pulse stripping voltammetry on hydrochloric acid digests of the teeth. High lev... | 274,065 | [
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The effect of storage on the activity of adrenaline in local anaesthetic solutions: an evaluation using bioassay and fluorometric techniques. | The adrenaline content of local anaesthetic solutions has been assessed using a bioassay system and a fluorometric assay method. It was found that exposure of the solutions to daylight for a period of six months greatly reduced their adrenaline content, whereas storage of the same solutions under refrigeration or in th... | 274,103 | [
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0.07329... |
Albumin-containing plasma volume expanders. | Human albumin-containing solutions have been used as plasma volume expanders and in the management of severe hypoproteinaemia for over 30 years; Modern indications for their use are described in some detail. These include the management of shock, burns, adult respiratory distress syndrome, and priming of the cardiopulm... | 274,123 | [
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Erythropoietin dependent erythropoiesis during the erythroblastic phase of juvenile chronic granulocytic leukaemia. | A child aged 3 1/2 years with typical juvenile chronic granulocytic leukaemia whose course terminated in an erythroblastic phase is described. Both in-vivo transfusion studies and in-vitro bone marrow culture studies indicate that red cell production remains erythropoietin dependent in this situation. The relationship ... | 274,145 | [
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0.03772941... |
Cytogentics of fibroblastic colonies in Ph1-positive chronic myelogenous leukemia. | The cytogenetic status of bone marrow stromal elements obtained from six patients with Ph1-positive chronic myelogenous leukemia (CML), two in blast crisis, was studied in vitro utilizing the potential of marrow to form surface-adherent colonies morphologically compatible with mesenchymal elements. We demonstrated the ... | 274,158 | [
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Significance of the cell cycle in commitment of murine erythroleukemia cells to erythroid differentiation. | The relationship between differentiation of murine erythroleukemia cells (MEL) induced by DMSO and the cell division cycle has been analyzed. We demonstrate that incubation in the presence of DMSO increases the length of the G1 phase of the cell cycle. A method of synchronization of MEL cells by unit gravity sedimentat... | 274,446 | [
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Thermal stimulation of the oral mucosa and nasal airway resistance. | A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wat... | 274,450 | [
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0.03233279... |
Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid. | Leukoplakia is neither a clinical, aetiological nor histopathological entity. Therefore treatment is difficult particularly in multifocal and advanced lesions. Since 1970, we have tested the therapeutic effect of different derivatives of all-trans-retinoic acid. The study includes 75 cases with homogeneous leukoplakia ... | 274,508 | [
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Control of occupational exposure to nitrous oxide in the oral surgery office. | Occupational exposure to inhalation anesthetics can be substantially reduced by control measures that have been recently developed. The incentive for their use should be the suspected relationship between chronic exposure to trace concentrations of agents, such as nitrous oxide, and health hazards. Control measures inc... | 274,530 | [
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Cooperativity in O2 binding to iron porphyrins. | The solid-gas O2 binding equilibrium has been studied for for ferrous "picket fence" porphyrinates with sterically hindered axial imidazoles. Such systems show significant cooperativity in their binding of O2: at low O2 pressures a low O2 affinity form exists, and at high O2 pressures a higher O2 affinity form develops... | 274,696 | [
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Cardiolipin: a stereospecifically spin-labeled analogue and its specific enzymic hydrolysis. | The spin-labeled cardiolipin 1-(3-sn-phosphatidyl)-3-[1-acyl-2-(16-doxylstearoyl)glycero(3)phosphol]-sn-glycerol has been prepared. The stereoselective synthesis makes use of the monolysocardiolipin 1-(3-sn-phosphatidyl)-3-[1-acyl-2-lyso-sn-glycero(3)phospho]-sn-glycerol, available from the stereospecific hydrolysis of... | 274,715 | [
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... |
Model for capping of membrane receptors based on boundary surface effects. | Crosslinking of membrane surface receptors may lead to their segregation into patches and then into a single large aggregate at one pole of the cell. This process is called capping. Here, a novel explanation of such a process is presented in which the membrane is viewed as a supersaturated solution of receptors in the ... | 274,724 | [
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Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle. | Because protein degradation in liver and skeletal muscle is increased by thyroid hormones and decreased by thyroidectomy; we investigated the influence of thyroid hormones on the level of lysosomal enzymes. Hypophysectomized rats received daily injections of L-thyroxine or L-triiodothyronine. After 3 days of this regim... | 274,725 | [
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Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages. | Alveolar macrophages have been shown to bind glycoproteins and synthetic glycoconjugates (neoglycorpoteins) that have mannose, N-acetylglucosamine, or glucose in the exposed, nonreducing position. Galactose-terminal glycoproteins are not bound. Binding of radiolabeled ligands to cells is nearly completely impaired by t... | 274,729 | [
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Probability of founder effect in a tribal population. | When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic the... | 274,730 | [
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Altered pattern of replication of human chromosomes in a human fibroblast-mouse cell hybrid. | The pattern of terminal replication of the human chromosomes in a clone of hybrids between diploid human fibroblasts and mouse cells was analyzed by autoradiography. An average of 10 human chromosomes was present in the hybrid cells. Several of these chromosomes were found to terminate replication in a different order ... | 274,734 | [
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Alteration in suppressor cell activity in chronic active hepatitis. | We have studied peripheral blood mononuclear cells obtained from 24 patients with acute or chronic active hepatitis to determine if there was an abnormality in concanavalin A-induced suppressor cell activity compared to control subjects. Suppressor cells were generated by preincubation of the mononuclear cells with a m... | 274,739 | [
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Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning. | The activity of single neurons recorded from rabbit hippocampus during classical conditioning of the nictitating membrane reflex was studied. All cells were first categorized according to their responses after fornix stimulation--i.i., antidromic activation, orthodromic activation, or no activation. The majority of cel... | 274,742 | [
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Calcium leakage as a cause of the high resting tension in vascular smooth muscle from the spontaneously hypertensive rat. | Aortic strips from spontaneously hypertensive (SH) rats relax in calcium-free physiological medium and contract to approximately 60% of maximum when calcium is again restored to the medium. In vivid contrast, the resting tension of aortic strips from normal rats is unaffected by manipulation of the calcium concentratio... | 274,745 | [
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Fine structure of the human secretory ameloblast. | The fine structure of secretory ameloblasts in primary tooth germs from a human fetus was investigated. Various aldehyde fixatives produced varying qualities of preservation. The morphology of the best preserved ameloblasts differed from that earlier described, mainly in the following respects: the rough endoplasmic ci... | 274,802 | [
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The oral clearance of chlorhexidine solutions and gels. | The oral clearance of 4 chlorhexidine (CH) preparations was investigated. Two 0.2% CH-solutions, Plak-Out liquid, a 10% alcoholic CH-solution and an aqueous ICI-Hibitane solution were compared with two chlorhexidine gels, Corsodyl gel (0.1%) and a test CH-gel (1.0%) prepared in this laboratory. Thirty subjects, 17 to 5... | 274,820 | [
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The cytologic appearance of metastatic transitional cell carcinoma. | Seven cases with cytologic material from metastatic transitional cell carcinoma are presented. Three cellular patterns were seen: 1) papillary fragments, 2) cells with a moderate amount of dense cytoplasm and 3) undifferentiated malignant cells. | 274,878 | [
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Cytologic findings in vaginal smears from patients under treatment with cyclophosphamide. | A report is given on the vaginal smears of 55 patients with ovarian carcinomas who were treated with cyclophosphamide either alone or in combination with other therapies. The changes occurring under the treatment are demonstrated and compared with the findings before therapy. A shift to lesser maturation depending upon... | 274,879 | [
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The circulatory effects of intravenously administered ephedrine during epidural blockade. | The changes in central circulation following a small dose of intravenously administered ephedrine were studied in middle-aged and elderly patients during high epidural blockade with bupivacaine 0.5% with adrenaline, etidocaine 1% with adrenaline, and etidocaine 1% plain. Itravenously injected ephedrine restored the mea... | 274,893 | [
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An approach to the management of temporomandibular joint dysfunction. | Temporomandibular joint dysfunction may result from a number of causes. Perhaps the commonest is muscular hyperactivity of central origin. Consequently, the dentist has to widen his investigations to take into account the life style of the patient and to deal with the expression of mental stress as muscular tension. | 274,927 | [
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Acute myeloblastic leukaemia with marrow fibrosis (malignant myelosclerosis): acute leukaemia or malignant myelosclerosis? | Malignant myelosclerosis has been described as a rare form of acute myeloproliferative disorder characterised by minimal or absent splenomegaly, cytopenias, circulating myeloblasts and diffuse marrow fibrosis, but distinction between this entity and acute myeloblastic leukaemia with marrow fibrosis is difficult. This r... | 274,942 | [
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The effects of smoking on the lungs. | The literature relating to tobacco smoking has been reviewed and is discussed under a number of headings. The smoking habits of Australians and people of other countries, the constituents of tobacco smoke and the different types of tobacco are discussed. The effects of tobacco smoke on lung defences and and function ar... | 274,943 | [
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Measurement of integral absorbed dose by chemical dosimeter in panoramic tomography. | As an aqueous chemical dosimeter for measuring ionizing radiation, the chemical 4,4' (5-chloro-2-thenilidene) bis [N,N-dimethylaniline], a derivative of the leuco triarylmethane compounds was used. This chemical dosimeter is an aqueous solution composed of 10(-4) M leuco compounds, 10(-4) M ferrous ammonium sulfate, 10... | 275,009 | [
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0.4990901,
0.4919624,
0.1343023,
0.1019748,
... |
Resistant level of houseflies to six kinds of synthetic insecticides in Malaysia. | The resistant level of the houseflies to six kinds of insecticides, DDT, Resmethrin, DDVP, Baytex, Sumithion and Diazinon, was examined on the seven strains collected in Malaysia. It was found that their susceptibility is rather higher than that of the Takatsuki strain which is a standard strain in Japan. However, thei... | 275,012 | [
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0.30... |
Survey of state funds available for rehabilitation of patients with cleft lip/palate. | An effort was made to determine the amount of funds budgeted in each of the 50 U.S. states for total rehabilitation of patients with cleft lip and/or cleft palate. Questionnaires were sent following a pilot letter to the directors of each state Department of Health. Total funds per patient ranged from $17,442 for Delaw... | 275,017 | [
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Evaluation of quandrant dentistry in provision of dental care. | The chairtime required for a single Class I or Class II amalgam restoration at 163 sittings was compared with the chairtime required for 99 cases in which two restorations in a quandrant were treated at the same sitting. The "Quadrant Dentistry Efficiency Rate" was calculated and it was found that quadrant dentistry re... | 275,018 | [
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An epidemiologic survey of periodontal disease in Dutch adults. | An epidemiologic survey was carried out to assess the prevalence and severity of periodontal disease in randomly selected samples of employed populations in the Netherlands. Of the 1,337 persons examined by five examiners, 19.8% were edentulous; 61% of dentate persons had intense gingivitis in an average of 2.4 segment... | 275,019 | [
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[The static (latent) bone cavity. A contribution of 3 cases to the unknown etiology]. | During one year 3 patients with static (latent) bone cavities were observed in the Clinic and Policlinic for maxil-lofacial surgery of the University of Münich. The findings are compared with reports from the literature and possible causes are discussed. | 275,048 | [
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Metastatic tumors of the hand: a report of six cases. | Six metastatic tumors of the hand of mammary, renal, pulmonary, colonic, and humeral origins are described. The areas involved were the distal phalanges, the metacarpal bones, a carpal bone, the nail bed, and the soft tissue of the dorsum of the hand. All six patients died within a few months after the metastatic lesio... | 275,346 | [
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Repeated use of L-asparaginase in multi-drug therapy of childhood leukemia. | The capacity of 1-asparaginase in two separate schedules (consecutive and intermittent), along with vincristine and prednisone to produce multiple responses, was evaluated in previously treated children with acute leukemia in relapse. The response rates varied inversely with previous 1-asparaginase exposure. A history ... | 275,534 | [
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[Fractures of the orbito-zygomatico-malar complex]. | Reference is made to the increasing number and severity of orbito-zygomatico-malar fractures brought about by the greater number of vehicles on the orads and their higher speeds. Fracture lines in such cases very considerably. An account is given of the therapeutical approaches usually followed at the Parma University ... | 275,538 | [
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The activity of methyl benzoquate and clopidol against Eimeria maxima: synergy and drug resistance. | Synergy between clopidol and methyl benzoquate against Eimeria maxima was shown to be supra-additive. Collateral sensitivity to these drugs could not be demonstrated in resistant lines of this parasite. Resistance to methyl benzoquate and clopidol was not transferred when lines of E. maxima, resistant to the respective... | 275,786 | [
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DNA unwinding induced by photoaddition of psoralen derivatives and determination of dark-binding equilibrium constants by gel electrophoresis. | Derivatives of furo[3,2-g]coumarin (psoralen) can bind to the DNA double helix and, in the presence of long-wavelength UV light, the bound psoralen may react covalently with pyrimidine residues on one or both strands of the helix. By using agarose gel electrophoresis, we have determined the unwinding angle associated w... | 275,838 | [
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De novo induction of a gene product during heterologous epithelial--mesenchymal interactions in vitro. | Mesenchymal specification of epithelial cytodifferentiation and morphogenesis has been considered to be a general feature of various epithelial-mesenchymal interacting systems (e.g., salivary gland, mammary gland, feather, hair, and tooth morphogenesis). In contrast, we have demonstrated that a mesenchyme can be induce... | 275,848 | [
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Cloned single repeating units of 5S DNA direct accurate transcription of 5S RNA when injected into Xenopus oocytes. | Single and multiple repeating units of three types of Xenopus 5S DNA recombined with the plasmid pMB9 serve as templates for the accurate synthesis of 5S RNA after their injection into Xenopus laevis oocyte nuclei. All 15 cloned single repeating units of X. laevis oocyte 5S DNA that were tested supported 5S RNA synthes... | 275,856 | [
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Hormonal induction of the secretory immune system in the mammary gland. | The secretory immune system of the mammary gland is undeveloped in virgin mice but becomes active at term and during lactation. This change appears to depend on migration to the mammary gland of precursors of IgA-secreting cells derived from the gut-associated lymphoid tissue, an origin which explains the specificity o... | 275,864 | [
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[Ultrastructure of achromic malignant melanoma of the gingiva. value in differential diagnosis]. | The authors report a case of a large oral tumour. On the basis of classical histological and histochemical techniques, the diagnosis was oriented towards an angiosarcoma though it was not possibile to eliminate an achromic melanoma. Ultrastructural studies demonstrated the presence of premelanosomes and established the... | 276,042 | [
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An evaluation of cytologic sampling techniques. A comparative study. | False negative cervical cytology is primarily due to errors in sampling. It has been demonstrated that combined ectocervical and endocervical sampling techniques will improve the yield. A prospective study was done to compare ectocervical and combined sampling with a selective technique in which the examiner determines... | 276,236 | [
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... |
Bone-marrow relapse in acute lymphoblastic leukaemia in childhood. | The outcome after bone-marrow relapse was assessed in 53 children with acute lymphoblastic leukaemia (ALL). Twenty-five out of 37 children (67%) whose first remission ended in relapse during treatment (group A) achieved a second remission, as did 15 out of 16 (94%) who relapsed after treatment had been stopped (group B... | 276,410 | [
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0.09356184,
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Enhancing effect of thoracotomy on tumor growth in rats. | To indicate the influence of operative stress on tumor growth, thoracotomy and/or laparotomy were performed 48 hr after intraperitoneal or intravenous inoculation of Sato lung cancer into Donryu rats. Survival period, number of metastatic nodules on the surface of the lungs, and the percentage-area of metastases in the... | 276,503 | [
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0.2403959,
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[Perthes disease after successfully treated acute juvenile lymphoblastic leukemia]. | The manifestation of Perthes disease after succesfully treated lymphoblastic leukemia is extremely rare. At the first signs of a femoral head necrosis--sonsidering the basic disease--and after cortisone treatment one has to think of a possible femoral head necrosis. It has been observed by several authors after long-te... | 276,512 | [
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Hemin control of heme biosynthesis in mouse Friend virus-transformed erythroleukemia cells in culture. | Hemin treatment of mouse Friend virus-transformed cells in cultured caused a dose-dependent increase in hemoglobin synthesis. By the addition of radioactively labeled hemin and by the analysis of the radioactive heme in hemoglobin, only 60 to 70% of heme in the newly synthesized hemoglobin was accounted for by the exog... | 276,528 | [
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Midface deviation due to mandibular fractures. (An experimental study with clinical comparison). | An experimental study was undertaken into the effect of fractures produced in the body of the mandible, the base of the condylar process and the mandibular condyles, on the bones of the middle third of the face using rabbit sucklings. The rabbits were sacrificed when fully grown, when it was found that in all cases the... | 276,554 | [
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0.1596676... |
Studies on platelet aggregation in vivo. VI. Effect of a pyrimido-pyrimidine derivative [RA233] on tumor cell metastasis. | The pyrimido-pyrimidine derivative RA 233 was found to increase circulation time and decrease metastatic settling of intravenously injected, radioisotope labeled ascites tumor cells in mice. | 276,567 | [
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Enhancement of heterotransplanted human tumor graft survival in nude mice treated with antilymphocyte serum and in congenitally athymic-asplenic (Lasat) mice. | The latency period, success rate, and minimal cell inoculum size required for transplantation of continuously passaged human tumor lines into congenitally athymic (nude) mice, antilymphocyte serum (ALS)-treated congenitally athymic (nude) mice, and congenitally athymic-asplenic (lasat) mice were compared. The 11 tumor ... | 276,631 | [
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The multistage theory of carcinogenesis and the age distribution of cancer in man. | The multistage theory of carcinogenesis is briefly reviewed, and the incidence function predicted by the theory is expressed as an "infinite sum" (convergent power series). This expression for the incidence function has the Armitage-Doll approximation as the first non-zero term and explicitly exhibits the dependence of... | 276,637 | [
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MCQ assessment of introductory clinical course for fourth year medical students. | A 60-item MCQ as administered to 46 fourth year medical students at the beginning, half-way, and at the end of a five week introductory clinical course. The stated goals were achieved: (1) a baseline measure was provided, indicating abilities brought by newly-arriving students; (2) data gave opportunity for "mid-course... | 276,703 | [
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... |
Pathology medical manpower planning in New Zealand results of 1977 survey. | As part of Medical Manpower Planning in New Zealand, a survey conducted by the New Zealand Society of Pathologists in association with the Royal College of Pathologists of Australia shows that at present there are 116 pathologists practising in New Zealand, a ratio of one to 27 000 population. This is far short of the ... | 276,713 | [
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... |
Effect of calcium on structure and function of a hyaluronic acid matrix: carbon-13 nuclear magnetic resonance analysis and the diffusional behavior of small solutes. | Natural-abundance (13)C NMR at 25.16 MHz has been used to study a 2.5% matrix of hyaluronic acid at various degrees of polymerization and at various ionic strengths. Peak assignment is facilitated by comparing proton-decoupled and off-resonance-decoupled spectra of a hyaluronidase-depolymerized matrix with spectra from... | 276,867 | [
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Fe-O2 bonding and oxyheme structure in myoglobin. | In the polarized electronic absorption spectrum of oxymyoglobin in single crystals, charge-transfer states involving orbitals of the iron and dioxygen ligand are defined as probes of oxyheme orbital structure and coordination geometry. The spectrum of sperm whale oxymyoglobin is diagnostic of a bent (formula: see text)... | 276,871 | [
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Enzymatic synthesis and rapid translocation of phosphatidylcholine by two methyltransferases in erythrocyte membranes. | The synthesis of phosphatidylcholine from phosphatidylethanolamine is carried out by two methyltransferases in erythrocyte membranes. The first enzyme uses phosphatidylethanolamine as a substrate, requires Mg2+, and has a high affinity for methyl donor, S-adenosyl-L-methionine. The second enzyme methylates phosphatidyl... | 276,878 | [
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0.04746732,
0.2047814,
0.405443,
0.05990947,
0.4511478,
-0.3959402,
-0.02503499,
-0.675797,
0.001223609,
-0.276764,
0.1275733,
0.4020845,
0.2399165,
-0.3675291... |
Behavioral effects and metabolic fate of N,N-dimethyltryptamine in mice pretreated with beta-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), improniazid and chlorpromazine. | Behavioral aspects and metabolic fate of N,N-dimethyltryptamine (DMT) were studied in mice pretreated with beta-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), iproniazid or chlorpromazine (CPZ). DMT at doses of 2.5, 10.0, and 25.0 mg/kg produced several behavioral changes in a dose-related manner: inhibition of s... | 276,891 | [
-0.2605194,
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0.3303735,
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0.3522112,
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0.07433777,
0.1965445,
0.3189698,
0.01665459,
0.2562263,
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-0.... |
Discoloration of permanent front teeth in 3,157 Norwegian children due to tetracyclines and other factors. | During routine orthodontic screening in Oslo, Norway, of 3,157 children, aged 1--11 years and born in 1963/64, 36 cases (1.14%) with cosmetically marring discoloration of permanent front teeth were registered. Thirty-four of them arrived for a more exhaustive examination, which in 24 of the children revealed positive t... | 276,912 | [
0.130652,
0.3398619,
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0.3232379,
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0.4995018,
0.3676676,
-0.0759216,
0.29... |
A 5-year evaluation of semipermanent composite resin crowns. | The use of composite resin crowns in the restoration of traumatized and hypoplastic permanent incisors has proved to be of great clinical and aesthetic value for the pedodontic practice. Due to the composite resin materials and the acid etch technique, an easy method of making and retaining the restorations is at hand.... | 276,914 | [
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0.4844028,
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0.04253079,
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0.3505641,
0.4113163,
0.0277043,
0.175... |
[When do we have to treat chronic leukemia?]. | The grounds for treating or not treating chronic lymphocytic leukemias (CLL) and chronic myelocytic leukemias (CML) are discussed in the light of results in recent years. In the case of CLL, objective evaluation of treatment benefits has hitherto been difficult due to the heterogeneity of this group of diseases. A rece... | 276,923 | [
0.1010436,
0.03363395,
0.1368099,
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0.02123458,
0.2021996,
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0.4228258,
0.4318658,
0.03766864,
-0.03960113,
... |
[Aims and realizations in the manufacture of articulators]. | The various designs of the most familiar articulators are described. Also the different concepts important to comprehending the stomatognathic functions are discussed. Their impact on the designs of various articulators are shown. The purpose of this study is not to given a complete review of the history and developmen... | 276,928 | [
-0.1267746,
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0.08388138,
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0.1369991,
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-0.2620952,
-0.0001855481,
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0.09990201,
0.3896233,
-0.03980027,
-0.2159... |
[Histopathology of oral precanceroses]. | The nomenclature used by gynaecopathologists for precancerosis of the cervix mucosa can be used equally for the oral mucosa. Cancer usually does not develop suddenly from a normal epithelium, but through an epithelial dysplasia into a non invasive, intraepithelial carcinoma. This process of cancerization probably lasts... | 276,930 | [
-0.273927,
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0.07131572,
0.1579498,
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0.110566,
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0.1835941,
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-0.04690364,
0.002097565,
-0.329755,
0.3390942,
0.1734181,
-0.1376925,
0.171... |
[Plate osteosynthesis in the mandible]. | The indications for plate osteosynthesis concern above all fractures of the edentulous or partially edentulous mandible. In cases of fractures in the anterior and premolar regions, the intra-oral approach should be given preference. The technique of plate shifting complies with the rules of the Working Group on Osteosy... | 276,952 | [
-0.3641154,
0.4324917,
0.1813733,
0.07885532,
0.2203392,
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0.05691028,
0.09780717,
0.03475266,
0.08540599,
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-0.08046976,
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0.2327238,
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0.3704727,
-0.03260135,
0.07833484,... |
Aspiration biopsy cytology in proliferating benign mammary dysplasia. | The accuracy of the cytologic diagnosis from needle biopsy in proliferating mammary dysplasia was tested on the basis of 101 histologically proven cases of mild to severe degree. The cytomorphologic presentation in smeared aspirate is described. A reliable cytologic diagnosis of proliferating mammary dysplasia was poss... | 277,037 | [
-0.1837258,
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0.009596279,
-0.02531545,
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0.04728277,
0.08317424,
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0.6810168,
-0.1361567,
-0.174149... |
Osteosarcoma of the metatarsal bones. Review of the literature and report of a case. | A case of osteosarcoma affecting the third metatarsal bone is submitted. Below-knee amputation was performed, but the patient developed pulmonary metastases and died 1 year after the operation. The six cases of osteosarcoma in the metarsal bones published so far are reviewed. The prognosis for cases with this localizat... | 277,054 | [
-0.3378042,
-0.1107175,
-0.2086172,
-0.3109807,
-0.3476743,
-0.02951113,
-0.2687517,
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-0.3756316,
0.006055718,
0.1942961,
0.1243332,
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0.08547575,
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-0.1200915,
0.2309573,
0.2871071,
-0.2494407,
0.04644727,
0.2337839,
0.235342,
0.1097783... |
Reliability of the CPRS between the disciplines of psychiatry, general practice, nursing and psychology in depressed patients. | To test the reliability and robustness of the CPRS in use by different disciplines we obtained 49 pairs of ratings on depressed patients in England and Sweden during treatment. Each rater pair consisted of a psychiatrist trained as a rater plus either a psychologist, a general practitioner, or a nurse, who had not been... | 277,055 | [
-0.02824128,
0.183118,
-0.009691502,
-0.2025087,
-0.003815547,
0.002739645,
-0.2142859,
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0.1443914,
0.1969765,
0.2509891,
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-0.2421812,
0.3612704,
-0.3389384,
0.2957309,
-0.2366928,
0.1826915,
0.04443... |
Long-term hypokalemia in acute myeloid leukemia. | A 48-year-old man suffering from acute myeloid leukemia presented a hypokalemia that persisted almost constantly during 18 months despite total hematological remission. The renal investigation demonstrated a hypokalemic nephropathy with an impairment of urinary concentrating function. Light and electron microscopy show... | 277,085 | [
-0.1539871,
0.01668762,
-0.1453737,
-0.2698463,
0.03952724,
-0.2383289,
0.08891881,
-0.03569683,
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0.1437273,
0.4224241,
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0.1075728,
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0.08539342,
0.1090347,
0.2736731,
-0.1052206,
0.3450322,
-0.05402593,
-0.1339511... |
Comparative cardiovascular toxicity of trazodone and imipramine in the rat. | Several authors have associated the cardiotoxicity of the tricyclic antidepressants with their capacity to potentiate the response to catecholamines. Trazodone is a psychotropic drug with a clinically proven antidepressant activity. It differes from the tricyclic antidepressants under several aspects (chemistry, pharma... | 277,097 | [
-0.3293989,
0.07804959,
-0.3409777,
-0.3381253,
0.2720281,
-0.383823,
-0.2761771,
-0.151511,
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0.3989221,
0.07418964,
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-0.03081324,
0.4642043,
-0.02882946,
0.2159697,
0.09962464,
... |
Drug excretion into eggs. An autoradiographic study. | Ulberg's whole-body autoradiographic technic has been used to illustrate the distribution pattern, the uptake to the oocytes and the excretion into the egg-white of 14C-trimethroprim, 3H-tetracycline and 14C-urea in Japanese quails. Marked differences were found in the uptake by the follicular epithelium between the oo... | 277,111 | [
-0.1425114,
-0.02546131,
-0.09526858,
-0.2968761,
0.3048963,
-0.536287,
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0.1493019,
0.1340205,
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0.3249973,
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0.3937694,
-0.2186666,
-0.1151617,
0.02409403,
0.3126851,
-0.06600009,
... |
Toxicokinetics. | The absorption, distribution and elimination of toxic compounds can be described by means of kinetic parameters such as used in pharmacology. Administration of toxic doses may lead to changes in some of the parameters. The toxic effect may further influence the known parameters of some test substances. Toxicokinetic pa... | 277,135 | [
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-0.008703788,
-0.4364193,
0.04790131,
0.3888742,
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0.3316741,
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0.1746052,
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-0.6174031,
0.8220633,
0.4232758,
0.1489619,
0.1458003,
0.3658918,
-0.1136881,
... |
Significance of induction phenomena. | A number of foreign compounds induce the proliferation of the hepatic smooth endoplasmatic reticulum and thereby increase the activity of monooxygenases that metabolize drugs and other foreign compound. With reference to the safety of food additives some antioxidants have been examined by various authors for their indu... | 277,136 | [
-0.5208526,
0.03685807,
-0.04985337,
0.1162803,
0.3431981,
-0.4353384,
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0.3656768,
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0.1474581,
-0.1864242,
0.3515004,
0.0007595646,
0.2990656,
-0.04448469,... |
Recent developments in dental plaque disclosants. | The use of erythrosin and fluorescein for disclosing dental plaque in 81 children aged 11-14 years and in 17 young men is reported. Erythrosin stained all plaque. When fluroescein was used, plaque, whether mature or recently exposed to sugars was disclosed under ultra-violet light. In the children, the erythrosin stain... | 277,142 | [
-0.07863013,
0.1838489,
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0.05267622,
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-0.1250476,
0.01877455,
0.09096795,
-0.1194829,
0.4201789,
0.2407537,
-0.38555... |
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