title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Acute myeloid leukemia with chromosome 5 deletion (a new syndrome)]. | This report deals with a new syndrome characterized by refractory anemia, an aberration of chromosome 5 (deletion of the long arm) and the subsequent appearance of acute myeloid leukemia. The results stress the importance of chromosomal studies in cases of unclear, long-lasting and therapy-resistant anemia, since they ... | 299,013 | [
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Cyclic hemopoiesis and feedback control. | Hemopoiesis exhibits a variety of oscillatory phenomena. Since hemopoiesis is controlled by many feedback loops and since feedback loops are potentially oscillatory, it is possible that the observed oscillatory phenomena are the result of movement of hemopoiesis into an area of operation which favors stable oscillation... | 299,070 | [
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[Dyserythropoietic anemia]. | The leading symptom of dyserythropoiesis is an increased, ineffective erythropoiesis with characteristic morphological and functional features. The molecular background of the disturbances is unknown. There are similar structural and biochemical characteristics with different etiologic factors. In addition to rare, con... | 299,214 | [
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[Specific immunotherapy in metastasizing breast cancer combined with chemotherapy. A prospective randomized study]. | 40 patients with metastasized mamma carcinoma were immunized with T-antigen, in addition to cytostatic therapy. A second group of 40 patients received cytostatics only. No improvement of remission rates could be obtained by additional immunotherapy with T-antigen. | 299,220 | [
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[Cytochemical aspects in bone marrow cells in macrocytic anemias]. | Cytochemical investigations are useful for the characterization of different kinds of macrocytic anemias. Vitamin B12 and folate defects or chronic alcoholic myelopathy, induce in the erythroblasts cytochemical patterns which can be distinguished from those seen in preleukemia, erythroleukemia, or in drug induced toxic... | 299,238 | [
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Haemoglobinometry in Papua New Guinea. | In 1978, doctors in Papua New Guinea were questioned about their practice of haemoglobinometry. Forty one doctors carried out blood haemoblobin measurements themselves, 26 used the Sahli method, 26 used a photoelectric absorptiometer method and 9 used the AO/Spencer haemometer. Thirty doctors had no occasion to ever ne... | 299,327 | [
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Patterns of use of Madang Hospital. | The patterns of inpatient use of Madang Hospital were examined. A highly disproportionate use of the hospital by the neighbouring population was demonstrated. The implications of this for health care planning are discussed and some methods of alleviating the inequalities in health care provision to urban as opposed to ... | 299,334 | [
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Testosterone metabolism in vitro by male sexual accessory glands from normal and autoimmunized rabbits. | In vitro metabolism of (3H)-testosterone from male accessory gland homogenates from autoimmunized and normal rabbits was studied at different times of incubation. Results indicated that 5 alpha - androstane-3 alpha, 17 beta-diol was the main metabolite formed in both cases, though the presence of the 3 beta-isomer cann... | 299,445 | [
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Current trends in the treatment of cancer of the larynx. | The case histories of 250 patients with cancer of the larynx presenting to the Peter MacCallum Hospital, the Alfred Hospital and the Royal Melbourne Hospital in the ten-year period 1966 to 1975 have been reviewed to determine: The results of primary irradiation treatment of T1N0 and T2N0 glottic cancer; The comparative... | 299,504 | [
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De-epithelialization and over-flapping in plastic surgery. | Contour defects resulting from trauma, from the excision of a neoplasm, or present at birth, may be restored in a number of ways, and the material used may be autogenous, homogenous, heterogenous, or synthetic in nature. The use of Silastic implants is currently fashionable, but despite the manufacturer's claims, there... | 299,513 | [
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Surgical manpower in New South Wales. | A series of surveys of general surgeons in the State of New South Wales is reported. Each five years the number of general surgeons entering practice has been proportionately greater than population growth, and has also been proportionally greater than that of other surgical specialities. The speciality is not growing ... | 299,516 | [
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Age at menopause in relation to reproductive history in Japanese, Caucasian, Chinese and Hawaiian women living in Hawaii. | A multiple regression analysis was undertaken to examine the relationship between age at menopause and selected biological and sociological variables in the reproductive history of Caucasian, Japanese, Chinese and part-Hawaiian post-menopausal women living in Hawaii. The analysis was conducted using the medical history... | 299,558 | [
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Age changes, cohort differences, and cultural change on the Guilford-Zimmerman Temperament Survey. | The relation between adult age and temperament was investigated using the Guilford-Zimmerman Temperament Survey. Between the years 1958 and 1974, the GZTS was administered to 915 men from 17 to 98 years of age in the Baltimore Longitudinal Study. Repeated measures were obtained for 336 men approximately 7 years after i... | 299,564 | [
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Performance and acquisition of serial position sequences by pigeons as measures of behavioral toxicity. | A procedure has been developed to measure the repeated acquisition of serial position sequences and to study the effects of drugs and toxic chemicals on the behavior generated by the procedure. Thus far experiments using the procedure have shown: (1) Performance schedules generate lower error rates than corresponding a... | 299,568 | [
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Cellular responses to neurotoxic compounds of environmental significance. | Many neurotoxic chemicals of environmental significance can be conveniently classified according to their cellular site of action in the nervous system. This paper considers neurotoxins which damage the nerve cell body (neuronopathy), its axonal process (axonopathy), or the myelin sheath which segmentally enwraps the m... | 299,578 | [
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Developing service-based teaching in health education for medical students. | In the expanding concern about the social-behavioral aspects of health care in medical education, health education has opportunities for making itself an important part of basic medical training. The need is to actually define a physician's appropriate educational tasks and competencies as a basis for curriculum develo... | 299,607 | [
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Reconstitution of cells by fusion of cell fragments. I. Myogenic expression after fusion of minicells from rat myoblasts (L6) with mouse fibroblast (A9) cytoplasm. | Rat L6 myoblasts and mouse A9 fibroblasts (HGPRT-) were enucleated by centrifugation of monolayers in the presence of cytochalasin B. Intact cells were reconstituted by Sendai virus mediated fusion of nuclei (minicells) from enucleated rat myoblasts and cytoplasms from enucleated mouse fibroblasts. Colonies arising fro... | 299,643 | [
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Technique of cervical myelography with metrizamide. | A technically simple modification of the prone posture technique for cervical myelography with use of metrizamide (Amipaque) after lumbar puncture is described. The procedure is well tolerated by the patients. | 299,658 | [
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Computer tomography in cisternography with metrizamide. | The preliminary results with computer tomography in cisternography with metrizamide (Amipaque) indicates that both normal and abnormal cerebrospinal fluid dynamics can be accurately displayed with the advantage of spatial and quantitative detail. The pharmacokinetics of metrizamide clearance from cerebrospinal fluid to... | 299,674 | [
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Transient areflexia following thoraco-lumbar myelography with metrizamide. Report of a case. | In a 32-year-old female areflexia occurred after thoraco-lumbar myelography with metrizamide (Amipaque), instead of the hyperreflexia usually found as a side effect of subarachnoid water-soluble contrast media. A direct neurotoxic effect on the cauda equina seems to have been the cause. | 299,681 | [
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Possible causes of complications of myelography with water-soluble contrast medium. | The mechanisms of CSF formation and absorption have been reviewed. The conditions that alter the rate of CSF formation and absorption may change the concentration of contrast in the cranial cisterns and the rate of passage through the cisterns. The significance of these alterations in relation to the complications of m... | 299,684 | [
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Thoracic myelography with metrizamide. | In 124 patients 141 thoracic myelographies were performed with metrizamide (Amipaque). This contrast medium penetrates narrow spaces more easily than gas and oily media. The technique and the positioning of the patient should be adapted to the region clinically suggested in order to obtain best results. | 299,688 | [
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Isolation and properties of DMSO resistant variant clones of Friend leukemia cells. | DMSO resistant clones have been isolated from the inducible Friend leukemia cell line 5-86 both from unmutagenized cultures and following EMS mutagenesis. All the clones can grow in the presence of 1.8% DMSO and are non-inducible or poorly inducible for hemoglobin synthesis by DMSO as well as by other known inducers of... | 299,704 | [
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Dihydroretinoic acids and their derivatives. Synthesis and biological activity. | The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds was evaluated in vivo in a chemically induced mouse skin papilloma test... | 299,711 | [
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Changes in hemopoiesis during the course of acute LCM virus infection in mice. | Although severe hematologic and immunologic disorders occur in several viral infections, insight into the mechanisms by which viruses may affect hemopoietic tissues is poor. The previous demonstration of distinct immunohemopoietic lesions in mice with acute lymphocytic choriomeningitis (LCM) virus infection has led us ... | 299,734 | [
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Immunoinhibition of ristocetin-induced platelet aggregation. | Human platelets washed and fixed in paraformaldehyde aggregate in the presence of the antibiotic ristocetin and normal plasma. This aggregation response is abolished after digestion of the fixed platelets with chymotrypsin. Antisera to fixed washed platelets were produced in rabbits and absorbed with chymotrypsin-treat... | 299,747 | [
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The active E-rosette test: a sensitive in vitro correlate for human delayed-type hypersensitivity. | The "active" rosette test was adapted as an in vitro assay and correlated with human delayed cutaneous hypersensitivity (DCH) to two microbial antigens. Peripheral lymphocytes were purified from donors known to be responders or nonresponders to PPD-tuberculin or tularemia on the basis of prior DCH reactions. Skin test ... | 299,750 | [
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Reaginic antibody formation in the mouse. IX. Enhancement of suppressor and helper cell activities of primed spleen cells. | Attempts were made to increase the activity of suppressor cells in vitro. Antigen-specific suppressor cells were induced by i.v. injections of urea-denatured ovalbumin (UD-OA) into OA-primed mice. Nonadherent splenic lymphocytes from the UD-OA-treated mice were incubated at 37 degrees C for 24 hr with either OA or OA-b... | 299,752 | [
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... |
Requirement for non T-cells in the generation of cytotoxic T lymphocytes (CTL) in vitro. II. Characterization of the active cells in the spleen of nude mice. | Small numbers of LN cells will produce many more cytotoxic lymphocytes on in vitro culture with allogeneic stimulator cells if spleen cells from nu/nu mice are also present throughout the culture period. All cytotoxic cells produced are T cells and arise from precursors in the LN component. The nude spleen component ap... | 299,753 | [
-0.06668623,
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0.254246,
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0.2301278,
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0.05132597,
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0.09330899,
0.4404161,
0.3305841,
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-... |
Immunosuppression of T lymphocyte function by fractionated serum from tumor-bearing mice. | Sera from mice with transplanted 3-methylcholantrene-induced tumors have been shown previously to inhibit the function of normal lymphoid cells. When chromatographed on Sephadex G-150, the fraction eluting with immunoglobulin has been shown to inhibit the proliferative response of normal spleen cells to concanavalin A ... | 299,757 | [
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0.2145054,
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0.1603455,
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-0.04901025,
0.5922784,
0.3148485,
-0.01705546,
-0.1051152,
... |
Tolerizing effect of DNP-ficoll on IgE antibody production. | A/J and DBA/1 mice were infected with 750 third-stage larvae of Nippostrongylus brasiliensis and immunized with 1 mug dinitrophenylated N. brasiliensis extract (DNP-Nb) with 1 mg Al(OH)3 to produce high titers of anti-hapten IgG1 and IgE antibody. Partial tolerance to the production of anti-hapten IgG1 and IgE antibody... | 299,759 | [
-0.1127313,
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0.1008539,
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0.1200694,
0.1233919,
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0.1720767,
0.01364446,
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0.1463927,
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0.1165687,
0.1725413,
0.2650273,
-0.2089245,
-... |
The adjuvant effect of Corynebacterium parvum: T-cell dependence of macrophage activation. | Splenic and peritoneal macrophages from mice treated with Corynebacterium parvum enhanced the antibody response in vitro of normal nonadherent spleen cells to SRBC, but not to DNP-POL. This enhancement was dependent on the dose and time of administration of C. parvum and could be abrogated by pretreatment with carragee... | 299,769 | [
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0.2068506,
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0.02959152,
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0.1388395,
0.08705192,
0.1269993,
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0.2631328,
0.08549468,
0.4662166,
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0.05314822,
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0.5617188,
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0.09703995,
0.01014835,
-... |
Immunochemical studies of infectious mononucleosis. VI. a radioimmunoassay for the detection of infectious mononucleosis heterophile antibody and antigen. | The coated-tube method of solid-phase radioimmunoassay has been adapted to the detection of heterophile antibodies and antigens of infectious mononucleosis. Disposable plastic hemagglutination trays were coated with purified glycoprotein from horse erythrocytes and the subsequent uptake of antibody from test sera was d... | 299,865 | [
-0.1992122,
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0.07305432,
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0.0642866,
0.001697391,
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0.3028541,
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0.2396866,
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0.4258018,
-0.0351043,
-0.004442... |
Food and intracranial stimulation responding suppressed with regular-interval shock. | Attenuation of conditioned suppression during intracranial stimulation was compared with that during food reinforcement. Response rates controlled by food and by brain stimulation were equalized on a multiple schedule by adjusting the stimulating current. When foot shock was delivered during timeout periods separating ... | 299,877 | [
-0.004992392,
0.1740699,
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0.3856792,
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0.007496802,
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0.05152237,
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0.05362541,
-0.3876049,
0.1491111,
-0.05263984,
-0.1747096,
0.18924... |
Coagulation factors influencing thrombosis of aorta-coronary bypass grafts. | Thirty patients in whom all aorta-coronary artery vein grafts became occluded within one year of operation, as demonstrated by cardiac catheterization, were evaluated for hypercoagulability. A total of 59 grafts were constructed in these patients. At operation, blood flows of 35 to 90 c.c. per minute were measured thro... | 299,908 | [
0.2439089,
0.3951153,
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0.1800709,
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0.131462,
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0.2037226,
0.6462792,
0.3316633,
0.02689325,
0.2760... |
External diseases of the eye. | The child presenting a red, tearing eye can pose a dilemma for the pediatrician. A good history and a careful systematic examination using good light and magnification should lead the physician to the proper diagnosis. The child with no complaints other than discharge probably has a conjunctivitis, while the child with... | 299,935 | [
0.01449224,
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0.2012038,
0.2862193,
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0.001195692,
0.5593456,
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0.2685596,
0.03939176,
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0.05499246,
0.07840243,
-0.1329423,
... |
Ribavirin: efficacy in the treatment of murine autoimmune disease. | Ribavirin, a drug with known antiviral activity, was given to mice with established lupus nephritis. Ribavirin was effective in prolonging survival, reducing the titer of antibodies to DNA, and reversing proteinuria. Other antiviral agents were not effective in the dosages used. | 299,957 | [
-0.1505243,
0.03997376,
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0.2401795,
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0.1292221,
-0.02017125,
0.4239775,
-0.08438091,
-0.1473731,
-0.22859... |
Characterization of a splenic factor inhibiting DNA-synthesis in lymphocytes in vitro. | A factor inhibiting DNA synthesis in lymphocytes from lymph nodes and thymus of guinea pigs and rats has been isolated from the calf spleen. A crude extract was obtained by homogenization of the spleen in saline, centrifugation at 1,200 and 46,000 g, heat precipitation at 60 degrees C, acetone precipitation, followed b... | 299,972 | [
-0.06125733,
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0.001920566,
0.1642099,
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0.2116865,
0.008625592,
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0.2228024,
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0.1157393,
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-0.3585102,
-0.1047895,
0.6466047,
0.05566707,
0.1331052,
-0.354547... |
Efficacy and risks of the distal splenorenal shunt in the treatment of bleeding esophageal varices. | Analysis of twenty-two patients who underwent distal splenorenal anastomosis shows that the operative mortality and morbidity are low if the indications for the procedure are strictly adhered to. The decompression of the esophageal varicosities is effective, even in the presence of persistent varicosities. This decompr... | 299,992 | [
0.1732119,
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0.05187532,
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0.1721873,
-0.06003532,
0.09333134,
-0.08145942,
-0.09938725,
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-0.04557811,
-0.08826853,
0.1857362,
0.2055742,
-0.1126312,
0.03588948,
0.4758337,
-0.090... |
[Emergency treatment of haemophilia A with factor VIII inhibitors using activated prothrombin complex concentrates (author's transl)]. | Severe rectal bleeding in a 6-year-old boy with haemophilia A and factor VIII inhibitors could not be stopped with factor VIII concentrates. But a good effect was achieved with activated prothrombin complex concentrates (fraction FEIBA), given over eight days. Amaurosis occurred as a complication after injection of the... | 300,053 | [
-0.2084536,
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0.1404749,
0.5845866,
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-0.06614102,
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-0.4186635,
-0.238028,
0.09112272,
0.3162881,
0.1543686,
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0.02213616,
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0.0197816,
-0.3491477,
0.05358868,
0.5299294,
0.03412747,
-0.09154874,
... |
Immunological studies in childhood scleroderma. | The results of immunological studies on 13 children suffering from scleroderma are reported. Antinuclear antibodies with speckled pattern of fluorescence could be found in systemic sclerosis and in 3 patients with scleroderma en bandes. The same patients (except but one with PSS) demonstrated high levels of DNA antibod... | 300,058 | [
0.2000854,
0.04213975,
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0.004389023,
0.01916836,
0.02841879,
0.07008003,
0.07726557,
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0.164407,
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0.1848457,
0.155729,
0.4781809,
0.5452931,
0.2950062,
0.0498926,
-0... |
5'-Nucleotidase in different populations of mouse lymphocytes. | The activity of 5'-nucleotidase in different populations of intact lymphocytes was studied using biochemical, cytochemical and radioautographic methods. In some strains of mice the results showed a consistent difference in 5'-nucleotidase (AMPase) content between intact thymic and splenic lymphocytes. In the R III, C 5... | 300,085 | [
0.01939664,
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0.088752,
0.1114506,
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0.01265637,
0.08036789,
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0.1916393,
0.05255743,
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0.152681,
0.4257977,
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0.1699921,
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-0.1440411,
0.08023466,
0.7392957,
0.2091549,
0.1700166,
0.06773864,
0.19... |
Haemophilus influenzae meningitis in infant rats: role of bacteremia in pathogenesis of age-dependent inflammatory responses in cerebrospinal fluid. | Abnormalities in cerebrospinal fluid associated with meningitis due to Haemophilus influenzae type b were characterized in infant rats. After intranasal inoculation of bacteria, the development of intense bacteremia (greater than 10(4) colony-forming units/ml) correlated with cultures of cerebrospinal fluid positive fo... | 300,094 | [
-0.05239036,
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0.1666784,
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0.1370629,
0.2506627,
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0.0784228,
0.3507926,
0.04579172,
0.21864,
-... |
[Ophthalmic use of clindamycin-2-phosphate (author's transl)]. | Bacterial and clinical experiments for ophthalmic use of clindamycin-2-phosphate (CLDM-2-P) were performed and the results were summarized as follows. 1. The distribution of sensitivity for 100 strains of Staphylococcus aureus isolated in 1975 was in the range of less than or equal to 0.19 approximately greater than or... | 300,120 | [
-0.3359112,
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0.1021238,
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0.1205165,
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0.2185379,
0.2732695,
0.04595315,
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0.05442184,
0.2026383,
0.1663533,
0.2914846,
0.2214262,
0.1053878,
-0.07... |
[Hydroelectrolytic disturbances secondary to high flow lavage used for the prevention of posthemorrhagic encephalopathy in cirrhosis]. | The authors carried out high flow intestinal lavage during gastrointestinal bleeding in cirrhotics in order to obtain rapid elimination of blood from the intestine and thereby reduce the risk of encephalopathy. The fluid used had been developed for preparation of the colon for surgery and was responsible for water and ... | 300,156 | [
-0.0998101,
0.09968862,
0.01353412,
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0.08392988,
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-0.09845748,
0.2594888,
-0.05609163,
0.05133... |
The role of granulocytes in colony stimulation by human white blood cells in agar cultures. Enhancement and inhibition of CSA. | The effect of polymorphonuclear granulocytes (PMN) on colony stimulating activity (CSA) was studied in double layer cultures of human Ficoll Isopaque separated white blood cells (mononuclear cells = MNC). Previously published data have been confirmed that granulocytes are able to enhance or inhibit MNC derived CSA. Fur... | 300,172 | [
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0.3842649,
0.5295485,
0.01795001,
0.1245162,
-... |
[Leiomyosarcomas of the inferior vena cava. Report of a case and review of the literature (author's transl)]. | A 55-year-old female with leiomyosarcoma of the middle segment of the inferior vena cava was successfully operated, 2 years ago. The literature is reviewed and pathology, symptoms, diagnosis and differential diagnosis, therapy and prognosis are thoroughly discussed. | 300,187 | [
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[The importance of inputimpedance of QRS-regulated pacemakers (author's transl)]. | As smaller the inputimpedance of a QRS-inhibited or synchronous pacemaker as higher the necessary energy for regulation. A method for measurement of inputimpedance of pacemakers is described. These impedances from several types are determined. It is a necessity to lead an intracardial ECG with a loading resistor like t... | 300,188 | [
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0.2110518,
0.402937,
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0.08288049,
... |
Correlative study of regional left ventricular histology and contractile function. | In 110 patients with documented coronary artery disease, transmural biopsy of the anteroapical region of the left ventricle was performed during aortocoronary bypass grafting. Biopsy specimens were semiquantitatively graded microscopically for myocardial fibrosis as an indicator of chronic ischemic damage. Preoperative... | 300,219 | [
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0.08831128,
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Selective deficiency of IgG and IgA as a first stage defect in B cell differentiation. | A case of selective deficiency of IgG and IgA, in a 13-year old girl, is described. Immunologic investigations, showing an almost complete absence of IgG- and IgA-bearing lymphocytes and significant amounts of IgD and IgM positive cells, suggest the possibility of a block in the shift from IgM to IgG synthesis at the B... | 300,257 | [
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0.1963939,
0.3847776,
0.07853391,
0.1115837,
... |
Stereotyped behaviour patterns and hyperactivity induced by amphetamine and apomorphine after discrete 6-hydroxydopamine lesions of extrapyramidal and mesolimbic nuclei. | Changes in stereotyped sniffing, biting and hyperactivity induced by apomorphine and D-amphetamine in the rat were determined after bilateral 6-hydroxy-dopamine (6-OHDA) lesions (8-16 micron/4micron6) of the extrapyramidal caudate-putamen (CP) (anterior and centre), globus pallidus (GP) and substantia nigra (SN), the m... | 300,267 | [
-0.0686426,
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0.3268333,
0.009291513,
0.3848442,
-0.02947388,
0.1187697,
0.04173183,
... |
Behavioral effects of lesions in the A10 dopaminergic area of the rat. | Experiments have been carried out with 150 rats in order to study some psychophysiological functions of the mesencephalocortico limbic dopaminergic A10 group. Lesions in the A10 area were made by using 6-hydroxydopamine (6-OHDA) local injections; 2 small volumes of injections were used at the same concentration (2 mug/... | 300,268 | [
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0.0001226859,
0.2470985,
0.05593324,
0.1777691,
... |
Predictive value of myocardial perfusion imaging for aortocoronary bypass surgery. | Evaluation of patients for aotocoronary bypass (ACB) surgery is dependent on the findings at cardiac catheterization. Left ventricular angiography cannot distinguish between reversible and irreversible myocardial dysfunction. In 82 patients macroaggregates of human serum albumin, labelled with iodine-131, were injected... | 300,272 | [
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0.01992421,
0.2935214,
0.2819098,
-0.09076397,
... |
Influence of left ventricular function and other parameters on early and late mortality following coronary bypass surgery. | Left ventricular performance, coronary anatomy and postoperative clinical parameters of 66 control patients (group 1) randomly selected from 797 survivors of coronary bypass surgery were compared with those of 45 patients who died within 30 days of operation (group II) and 53 patients who died late (average, 22+/-2 mo)... | 300,273 | [
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0.3649131,
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0.07772271,
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0.2997347,
0.2798113,
0.4208387,
-0.3170... |
Relationship of surface immunoglobulin-bearing cells, plasma cells, and tumor development in anaplastic carcinoma-bearing A/J mice. | Since the humoral immune response has been shown to be associated with immunological enhancement of tumor growth, the study of surface immunoglobulin-bearing cells and plasma cell antigen (PCA)-bearing cells during neoplastic development may provide new approaches to the study of tumor immunology. Peripheral blood was ... | 300,278 | [
0.1448003,
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0.2040713,
0.2489688,
0.3821311,
-0.04299276,
-0.08376861,
... |
Role of self-carriers in the immune response and tolerance. II. Parameters of tolerance induced by haptenated lymphoid cells. | The induction of tolerance to the 2,4,6-trinitrophenyl (TNP) hapten has been studied in a system utilizing haptenated syngeneic lymphoid cells. Specific depression of the direct and indirect plaque-forming cell (PFC) responses to TNP-protein conjugates was regularly achieved by pretreatment of Lewis rats with 1 X 10(7)... | 300,326 | [
0.04887874,
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0.1132427,
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0.1297691,
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0.1206195,
0.006875085,
0.2114174,
0.03750295,
0.2027117,
0.08402736,
-0.1202896,
-0.7840598,
-0.2199048,
-0.4844499,
0.1284641,
0.1884059,
0.5159391,
-0.001217818,
0.2690604,
0.03141467,
-... |
Vestibular units during decompensation. | Typical modifications of the unitary discharge of vestibular units have been recorded following the transection of the spinal cord of hemilabyrinthectomized and compensated guinea-pigs. These results support the concept that the spinal cord is essential in the compensation of the symptoms resulting from a lesion of one... | 300,333 | [
-0.09370242,
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0.01803005,
0.07830189,
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0.1825875,
0.1242208,
... |
Studies on the product of antigenic recognition. III. Nature of PAR. | The product of antigenic recognition (PAR) is an antigen-antibody complex with granulotactic activity. The following results support his conclusion. PAR generated by cell-bound or shed T-cell RS or the recognizing structure of T alloantisera and alloantigen can be destroyed by heating at 56 degrees C for 30 min, becaus... | 300,336 | [
0.04489166,
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0.05148872,
0.2570724,
0.1536035,
0.2239471,
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-0.... |
Colony growth in vitro of mitogen-stimulated mouse B lymphocytes. | The ability of mouse B-mitogen-induced lymphocytes to grow and develop into colonies in a soft agar system was studied. Prerequisite conditions for the colony formation of mouse lymphocytes from inguinal lymph nodes of strains ICR C3H/eB and C3H were their suspension in a liquid medium and stimulation with polyclonal B... | 300,358 | [
0.3330861,
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0.02708166,
0.256087,
0.6750669,
-0.02656105,
-0.03449368,
-0.15923... |
O2 consumption of the amphibian cornea: relationship to Na+ and Cl- and the presence of drugs. | Thirty percent of the O2 consumption of the amphibian cornea was Na-dependent. Ouabain, in the presence but not the absence of this cation, inhibits O2 uptake by about 30 patient. In contrast, neither the presence of Cl- nor drugs which stimulate (adrenaline, theophylline) or inhibit (furosemide, thiocyanate) active tr... | 300,374 | [
-0.1945837,
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0.05102899,
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0.07563001,
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0.02850964,
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0.1345634,
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-0.2413439,
0.10051... |
Analysis of the major histocompatibility complex in Syrian hamsters. III. Cellular and humoral immunity to alloantigens. | Among the genetic loci incorporated into the major histocompatibility complex in every species studied to date have been prominent genes encoding for strong histocompatibility determinants that elicit detectable alloantibody responses and which are the chief antigenic targets of cell-mediated cytotoxicity reactions. Th... | 300,388 | [
-0.0443321,
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0.1574178,
0.5471363,
0.2564072,
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-... |
Cross-linking of T cell mitogens: effects on B and T cell proliferation and immunoglobulin synthesis. | The T cell mitogens Pa-2, concanavalin A (con A) and its dimeric derivative succinyl-con A, were each cross-linked with the bifunctional reagent dimethyl suberimidate. Although the dose-response curves of these insoluble aggregated products were markedly changed from those of the soluble mitogens, each aggregate contin... | 300,391 | [
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0.2326025,
0.6000394,
0.1635838,
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Interactions between human lymphocytes and paramyxovirus-infected cells: adsorption and cytotoxicity. | The capacity of human lymphocytes to adhere to paramyxovirus-infected monolayers and their capacity to kill paramyxovirus-infected cells was investigated. A large fraction of human lymphocytes was found to adhere firmly to the paramyxovirus-infected monolayers. Predsorption of lymphocytes on mumps virus-infected cells ... | 300,397 | [
-0.3480567,
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0.2740658,
0.1917453,
0.09057347,
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... |
Radiosensitivity of T and B lymphocytes. IV. Effect of whole body irradiation upon various lymphoid tissues and numbers of recirculating lymphocytes. | Groups of 10-week-old female CBA/J mice were exposed in whole body fashion to 0,5,50, and 500 rads and sacrificed in serial fashion 1,3,5,7,9,15, and 30 days after irradiation for morphologic evaluation of thymus, spleen, lymph node, and Peyer's patch, and assessment of the relative numbers of thymus-derived (T) and bo... | 300,402 | [
0.03931139,
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0.4340068,
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0.222072,
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0.008163812,
0.2785664,
0.3132702,
0.3931771,
0.03226373,
-... |
Factors influencing the differential sorption of odorant molecules across the olfactory mucosa. | By use of a flow dilution olfactometer, tritium-labeled odorants were presented through the external naris to the bullfrog's intact olfactory sac. After stimulation the animal was frozen in liquid nitrogen. The dorsal surface and eminentia of the olfactory sac were then removed and sawed into sections perpendicular to ... | 300,427 | [
0.02046548,
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0.02232771,
0.07576098,
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0.3689684,
0.03936571,
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0.09905525,
0.006256569,
0.04717192,
0.3452322,
-0.1521882,... |
Inhibition of spontaneous and antibody-dependent cellular cytotoxicity by sera and isolated antiglobulin preparations from rheumatoid arthritis patients. | Using sera from patients with rheumatoid arthritis and antiglobulin preparations obtained from such sera, inhibition of human lymphocyte cytotoxicity in antibody-dependent (ADCC) and spontaneous cell-mediated cytotoxicity (SCMC) reactions against an allogeneic melanoma cell line (IGR3) has been demonstrated. Fractionat... | 300,499 | [
-0.0362814,
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0.1853075,
0.1615237,
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0.2796542,
0.2837043,
0.2326502,
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0.4012068,
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0.02353008,
0.0899325,
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0.1785842,
0.355159,
0.4146893,
0.01507594,
-0.1014191,
0... |
Ligation procedures in the management of portal hypertension. | In the 10 year period from 1964 through 1973, 25 patients bleeding from esophageal varices underwent ligation procedures coupled with splenectomy rather than a shunt. These procedures included the transesophageal and transgastric approaches and extragastric ligations. For patients with normal liver function, the risk o... | 300,509 | [
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0.05856979,
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0.1007882,
0.03088238,
0.2317322,
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0.05156165,
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0.0169437,
0.08325823,
0.2609779,
-0.1950... |
Effects of amyl nitrite on phasic aortocoronary bypass graft blood velocity in man. | With the use of a Doppler flowmeter catheter, phasic instantaneous aortocoronary saphenous vein bypass graft blood velocity was continuously measured during the inhalation of amyl nitrite in 20 closed-chest conscious subjects. Administration of amyl nitrite augmented peak diastolic and systolic graft blood velocity wit... | 300,556 | [
-0.2861955,
0.06081095,
-0.7981167,
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0.02456561,
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0.1519916,
0.3054077,
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0.2464177,
0.361133,
0.5742874,
-0.04786071,
0.03827021,... |
Fine structure of the secretory and nonsecretory ameloblasts in the frog. I. Fine structure of the secretory ameloblasts. | Amelogenesis in the tooth germs of the frog Rana pipiens was examined by electron microscopy at different stages of tooth development. Cellular changes in secretory ameloblasts during this process showed many basic similarities to those in mammalian amelogenesis. Amelogenesis can be divided into three stages based on h... | 300,559 | [
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0.1861996,
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0.2084864,
0.1192149,
0.3398454,
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0.04345805,
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0.07057479,
0.3656348,
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0.4021424,
0.1470891,
-0.08096971,
... |
Risk factors in chronic obstructive pulmonary disease (COPD). | In a genetic-epidemiologic study of chronic obstructive pulmonary disease (COPD) observations adjusted for age, sex, race, and smoking indicate certain factors to be associated with increased pulmonary function aberrancy, and suggest that they are risk factors for COPD. These presumptive "risk factors" include not only... | 300,564 | [
0.198348,
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0.00056976,
0.2162334,
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0.01622397,
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0.07186713,
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0.05189599,
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0.4481376,
-0.04095532,
-0.01043448,
0.2710455,
-0.1... |
[Genetic control of the H-2 region of the cell surface: cationic amino groups in the periphery of T lymphocytes]. | Spleen lymphocytes and erythrocytes from congenic mice of diffrent haplotypes were characterized on a precise biophysical basis (the anodic electrophoretic mobility, EPM) to correlate any subtle differences in the cell surface topochemistry with the H-2 specificity. Spleen T lymphocytes from A.CA (H-2f) and A.SW (H-2s)... | 300,597 | [
-0.1233026,
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0.2212448,
0.2628221,
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0.07208012,
0.1698782,
0.28023,
0.2270484,
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0.4185347,
0.1366718,
0.2275012,
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-0.1880129,
-0.06644171,
0.1554774,
0.3299474,
0.2789777,
-0.3466333,
-0.448... |
Lupus-like syndrome associated with carcinoma of the breast. | Two patients with locally advanced carcinoma of the breast had radiation therapy as primary treatment. Within one year, a lupus-like syndrome developed characterized by pneumonitis, pleural effusion, and positive fluorescent antinuclear antibody (FANA) reaction and lupus erythematosus (LE) preparation. Pericarditis dev... | 300,616 | [
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-0.05224963,
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0.1259411,
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0.3712333,
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0.2523257,
0.1960465,
0.4826025,
0.05718722,
-0.23827,
... |
Ultrastructure of the spleen in malignant histiocytosis. | We examined the ultrastructure of the spleen surgically removed from a patient with the in vivo diagnosis of malignant histiocytosis. The findings showed sinuses greatly dilated and lined by large atypical histiocytic cells. Erythrophagocytosis was prominent. These findings, as well as the histologic features of the bo... | 300,617 | [
0.0799947,
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0.01680595,
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0.2988277,
0.02420325,
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0.08403139,
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-0.08375755,
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0.2663358,
-0.057021,
-0.001959888,
0.3255026,
-0.03... |
[Cytotoxic serum against B-lymphocytes obtained by immunization with bone marrow cells]. | Immunization of rabbits with the bone marrow cells of intact mice permitted to obtain antisera selectively reacting with the cells of the bone marrow origin. A method of obtaining the anti-B-sera by immunization of animals directly with the bone marrow cells permitted to exclude irradiation and thymectomy of mice, this... | 300,635 | [
-0.1179352,
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-0.02241551,
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0.04184679,
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0.1199297,
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0.09547611,
0.06802697,
0.06046471,
0.1687834,
0.06918241,
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0.1094447,
0.5775332,
0.4456757,
-0.1207109,
-0.04669295,... |
Bypass graft for coronary arterial stenosis following radiation therapy. | A 48-year-old man developed symptoms of progressive angina pectoris leading to myocardial infarction 12 years after two large doses of radiation for treatment of superior vena caval syndrome. Angiographic studies showed an isolated critical stenosis in the left anterior descending coronary artery, for which a successfu... | 300,671 | [
-0.3286154,
0.2446229,
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-0.04291568,
0.1568752,
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0.2235662,
0.326478,
0.1200632,
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0.1799632,
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0.09742213,
0.08076907,
0.2168754,
0.4577703,
-0.06749823,
0.21... |
Acute effects of low doses of clomiphene upon LH release in ovariectomized estrogen-progesterone treated rats. | The acute effects of low doses of clomiphene citrate upon serum LH within the first two hours after the intravenous injection into ovariectomized, estrogen-progesterone blocked rats were investigated. There was a short-lasting elevation of LH release 45--60 min after injection of 2.5 microng clomiphene. A second LH rel... | 300,678 | [
-0.0769271,
0.04623219,
-0.1230431,
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0.01928519,
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0.09941375,
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0.5285892,
0.04226363,
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0.04610484,
0.1107064,
-0.02577716,
0.1720563,
0.3773285,
0.1588839... |
Inhibition of DNA synthesis in concanavalin A stimulated rat lymph node cells by serum from arthritic rats. | Serum from adjuvant arthritic rats inhibits the mitogenic response of rat lymph node cells to concanavalin A, leaving unaffected the response to phytohemagglutinin. This activity is already evident 4 days after adjuvant administration and persists for at least 28 days. | 300,688 | [
0.05050213,
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0.2069922,
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0.61847,
0.2476441,
-0.09577492,
-0.1834506,
0... |
[The protective effect of sodium selenite and vitamin E in hypervitaminosis D]. | Vitamin D2 (160 000-240 000 IU/kg) produced during 5 days pronounced hypercalciemia and metastatic calcification of internal organs. Subcutaneous injection of sodium selenite (10 mg/kg) brought down the level of calcium in the blood plasma and decreased calcification of internal organs. Conjoint introduction of sodium ... | 300,690 | [
-0.3749447,
-0.07466136,
-0.07771724,
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0.2560742,
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0.05564545,
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0.1989366,
0.559993,
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0.02809432,
0.2940038,
0.3815966,
0.4501466,
-0.08420546,
... |
Age-related variation in lymphocyte subpopulations. | Peripheral blood lymphocytes are heterogeneous and can be divided into subpopulations based on cell surface markers. Lymphocytes from 101 normal individuals of all ages were tested for their ability to form spontaneous rosettes with sheep erythrocytes (T cells) and for surface immunoglobulins (B cells). Cord bloods of ... | 300,698 | [
-0.0763552,
-0.1421183,
-0.03873939,
0.01822498,
0.2850176,
-0.6498458,
-0.2432515,
0.0009268482,
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0.3598182,
0.03318224,
0.2382856,
-0.04914302,
0.259304,
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-0.2930572,
0.06455648,
-0.03909955,
0.3415519,
0.1347838,
0.3070416,
-0.0944924... |
[New methods in the treatment of weather sensitivity]. | Changing weather fronts produce severe changes of daily rhythms. Electrical impulses arrive 1-2 days before the weather and create either atmospherics or "positive ions". They are responsible for the epidemic appearance of migraine and of thrombo-embolism. The impact of atmospheric electricity has been assessed in 1000... | 300,702 | [
-0.2097169,
-0.04801394,
-0.008089773,
0.04127209,
-0.06677248,
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-0.06062669,
-0.1513701,
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-0.1752623,
0.07819355,
0.09992443,
0.3023416,
-0.2526216,
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0.08126895,
0.2395,
0.1633379,
0.203383,
-0.4812567... |
[Pulmonary mycoses; laboratory diagnosis, antimycotic therapy]. | The microscopic, cultural and serological techniques for the diagnosis of European and non-European systemic mycoses involving the respiratory tract are reviewed. The antimicrobial, therapeutic and toxic properties of those antimycotic drugs are discussed, which can be used in the treatment of pulmonary mycoses. Data o... | 300,705 | [
-0.008187695,
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-0.03498942,
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0.06041616,
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0.02154003,
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0.1533736,
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0.1434175,
0.357515,
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-0.3147661,
0.2802608,
0.1223824,
0.2661976,
0.4399619,
0.2187517,
0.02826849,
... |
Studies on immune responses to parasite antigens in mice. V. Different susceptibilities of hypothymic and intact mice to Babesia rodhaini. | Hypothymic BALB/c.nu/nu mice are more resistant than intact BALB/c.nu/+ mice to Babesia rodhaini and a proportion survive a dose of infected blood which is uniformly lethal to nu/+ mice. This proportion of nu/nu survivors is not affected by administration of an anti-Babesial drug, whereas the majority of nu/ + mice dev... | 300,714 | [
0.1326542,
-0.4636853,
-0.1405448,
-0.2033803,
0.1448693,
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0.1281925,
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0.2080338,
0.1137635,
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0.1857516,
0.03792801,
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0.318186,
0.03406754,
0.3596939,
0.1554776,
0.09294599,
-0.1403133,
-0.0071... |
Modification of the radiosensitivity of barley seed by post-treatment with caffein. IV. Effect of the moisture content of seed and storage temperature after irradiation. | The oxygen-dependent damage which develops in barley seeds with approximately 7-8 per cent moisture content disappears after post-irradiation storage in vacuo for 48 hours at 40 degrees C and for 24 hours at 50 degrees C. When the diration of storage at 40 degrees C is extended to 384 hours, oxygen-independent damage b... | 300,722 | [
0.06519263,
0.262647,
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0.119501,
0.08296044,
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0.2097409,
0.2020729,
0.1984181,
0.3793042,
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0.119627,
0.2850841,
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0.09912756,
0.1078985,
0.23261,
-0.1927996,
0.11944... |
Background adaptation in the rods of the frog's retina. | 1. Aspartate-isolated photoresponses of the red rods to flashes and steps of light have been recorded, both in the presence of and without background lights of varying strength. 2. The results are interpreted in terms of a model of rod outer segment adaptation, where the three model parameters correspond to the adaptat... | 300,800 | [
-0.1043089,
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[Scanning electron microscopy of cultures of macular dystrophy of the cornea]. | The scanning electron microscope shows that the keratocytes of the macular dystrophy of the cornea have an irregular and anfractuous surface and that some cytoplasmic particles are broken off. This explains the isolated elements found in the stroma. | 300,861 | [
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0.05823... |
Local starvation for epidermal growth factor cannot explain density-dependent inhibition of normal human glial cells. | Mouse epidermal growth factor (mEGF) is a potent growth promoter of human glial cells in sparse cultures, whereas very little stimulation of growth in dense cultures is induced by the factor. In the present communication, the possibility that the density-dependent inhibition is caused by a reduced binding/uptake of the... | 300,875 | [
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0.1772239,
... |
Protease-induced constriction in rats' bronchi. | A method is described which allows quantitative measurements of bronchomotor function in vitro in all parts of the tracheobronchial tree. With this method it was observed that chymotrypsin, trypsin and ficin elicted contraction in the intrapulmonary airways of rats. The response could be abolished or diminished by phen... | 300,894 | [
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0.07702802,
0... |
[Vascular reconstruction in arterial occlusion of the lower leg (author's transl)]. | In 84% of 115 femoro-crural arterial occlusions stage III and IV was present. All operations to revascularisation, including second operations could be performed without lethality. On leaving hospital in 93% the bypass was patent. Two to nine years after the operation in 64% of the venous grafts were good. Only eleven ... | 300,915 | [
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0.3007344,
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... |
[Diathermic coagulation via endoscope for stopping gastric hemorrhages]. | The authors studied experimentally the effect of different methods of diathermocoagulation on gastric wall and the possibility to arrest gastric hemorrhages of various intensity by means of the methods under consideration. Monoactive diathermocoagulation, as compared with biactive one, was found to produce more extensi... | 300,934 | [
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0.001663899,
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[253 patients with acute pancreatitis treated at the surgical clinic in Zagreb]. | 253 patients with acute pancreatitis were treated in clinic for surgery in Zagreb through last 23 years. The most frequent cause of pancreatitis were diseases of biliary tract, obesity, vascular deseases, alcoholism etc. In the symtomatology, the pain was present in all patients and majority of them had abdominal sympt... | 300,970 | [
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0.01369937,
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[Histocompatibility antigens and open-angle glaucoma (author's transl)]. | In 41 patients with open-angle glaucoma and 450 healthy, unrelated controls of identical ethnic origin the frequencies of 36 HLA antigens were determined using the microlymphocytotoxicity test. In contrast to recent publications it was not possible to confirm a significant difference in the incidence of the antigens in... | 300,999 | [
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0.2356217,
0.06107922,
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... |
Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin. | The antibacterial activity of netilmicin (Sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. Both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity again... | 301,004 | [
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0.1398233,
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-0.0384510... |
Gastrointestinal hemorrhage in Turner syndrome. Long-term follow-up with postmortem examination. | A 57-year-old woman with Turner syndrome had severe recurrent gastrointestinal bleeding. Exploratory laparotomy at the age of 26 showed an extensive telanglectasia of the entire small intestine. Following death due to myocardial infraction at age 57, postmortem examination revealed only a 0.2-cm residual telangiectasia... | 301,017 | [
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0.1520389,
0.01553479,
0.283091,
0.4304787,
-0.2008726... |
Acetylator phenotype in systemic lupus erythematosus. | The acetylation rate of sulfamethazine was studied in 25 patients with systemic lupus erythematosus (SLE). Seventeen of 25SLE patients, 68%, were slow acetylators compared to the reported incidence of 52% in the general population. There was no correlation between the acetylator phenotype in SLE patients and the variou... | 301,027 | [
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Marker properties of tumor and lymphoid cell lines derived from a patient with squamous cell carcinoma. | A squamous cell carcinoma tumor cell line, COLO 227, derived from a metastatic tumor in a Caucasian male, produces both parathyroid hormone and carcinoembryonic antigen. A chromosome mode of 106 predominated and the X and Y chromosomes were retained. Seven marker chromosomes were identified. Cytogenetic analysis reveal... | 301,054 | [
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0.4966469,
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0.3... |
Surface immunoglobulins of lipopolysaccharide-stimulated spleen cells. The behavior of IgM, IgD and IgG. | The nature of Ig receptors carried by lipopolysaccharide (LPS)-stimulated mouse spleen B cells was analyzed by surface iodination, direct antiserum precipitation and polyacrylamide gel electrophoresis. LPS activation led to a rapid decrease of surface IgD to 20 % and 80 % of the original level on days three and five of... | 301,090 | [
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0.1662614,
0.002435835,
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... |
[Specificity of the effect of thrombin on the chemoreceptors of the frog carotid labyrinth]. | Perfusion of thrombin and trypsin solutions through the frog carotid labyrinth acts on the carotid chemoreceptors and evokes reflex response of the anticoagulating system. The similarity of effects of both these agents seems to be due to similarity of their structures. Other agents acting on the frog vascular chemorece... | 301,103 | [
0.2394032,
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... |
Clomipramine (Anafranil) and musculo-skeletal pain in general practice: a pilot, open, non-comparative study of long-standing rheumatic pain. | Forty-six patients were admitted to an open general practice study of clomipramine (Anafranil) in the treatment of long-standing rheumatic pain; forty-one patients completed the trial. The duration of the trial was 56 days during which patients received daily doses of either 10 mg or 25 mg of clomipramine. Assessments ... | 301,105 | [
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A bleeding Meckel's diverticulum diagnosed by arteriography. | A case of Meckel's bleeding diverticulum diagnosed by emergent arteriography is presented. Arteriography revealed an extravasation of contrast medium into the distal ileum and an abnormal ileal artery which passed to the antimesenteric border of the ileum. The diverticulum was demonstrated by double contrast study of t... | 301,107 | [
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0.01817149,
0.00700... |
[Radioimmunoassay of fibrinopeptide A: double antibody method]. | A radioimmunoassay kit was used for measurement of human fibrinopeptide A in plasma. The "charcoal technique" was replaced by the more precise double-antibody method. The possibility of automation allows a shortening of the time for performing the assay and a more general clinical use. Normal values and preliminary res... | 301,111 | [
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0.2559325,
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0... |
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