title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Model for carbohydrase action. Aspergillus oryzae alpha-amylase degradation of maltotriose. | Aspergillus oryzae alpha-amylase catalyzes degradation of oligosaccharides by a variety of pathways. We present here a quantitative study of the degradation of maltotriose by this amylase. Our results lead to a scheme involving multiple transglycosylation reactions and shifted binding due to simultaneous binding of two... | 307,964 | [
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Serum copper and zinc measurement in patients with osteogenic sarcoma. | Serum copper level (SCL), serum zinc level (SZL), and SCL/SZL ratio were measured in 18 patients with biopsy-proven osteogenic sarcoma. Measurements were made on sequentially collected serum samples beginning prior to the institution of therapy and continuing periodically until documented relapse. All patients were tre... | 307,981 | [
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[Porphyria cutanea tarda: possible treatment and its results (author's transl)]. | In 4 of 12 patients with porphyria cutanea tarda (PCT) treatment with p-aminobenzoic acid (PABA) achieved normal porphyrin excretion and disappearance of the skin changes. But this result is far worse than that obtained with the venesection method of Ippen. PABA treatment should, therefore, be discontinued.--Among 56 p... | 308,001 | [
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[Gastrointestinal complications of acute pancreatitis (author's transl)]. | Gastrointestinal complications, such as ileus, bleeding, stenosis and fistula formation, were retrospectively analysed on 180 patients with acute pancreatitis. Paralytic ileus occurred in only a quarter of patients with acute oedematous pancreatitis and only one had bleeding from a gastric ulcer. Complications occurred... | 308,003 | [
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Group-specific component, alpha1-antitrypsin and esterase D in Canadian Eskimos. | Three genetic markers - group-specific component (Gc), alpha1-antitrypsin, and esterase D - were examined in a population of Eskimos from Igloolik in the eastern Canadian Arctic. Gc and esterase D were found to be polymorphic. In addition to the common Gc types, an anodal variant called Gc Igloolik was found, probably ... | 308,031 | [
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Alpha-1-antitrypsin phenotypes in newborns from Central and Southern Italy. | The results of Pi typing on 500 infants from Central and Southern Italy are reported. Phenotype determinations were performed on umbilical cord serum. We observed nine different phenotypes; each of these is present in other European populations. The frequencies of the Pi alleles in our group were found to be, on the wh... | 308,032 | [
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The rejoining of DNA double-strand breaks and a model for the formation of chromosomal rearrangements. | The recombination type of process, which has been proposed by Resnick to explain the rejoining of radiation-induced DNA double-strand breaks, is combined with the molecular theory of radiation action to provide a description of the formation of chromosomal rearrangments. It is shown that the majority of chromosomal abe... | 308,051 | [
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Interaction of aminoacridines with nucleic acids. A pulse-radiolysis study. | Pulse radiolysis has been used to study the interaction of aminoacridines with nucleic acids. The data confirm that there are two modes of binding. These are: a weak interaction which has a maximum binding ratio of one site per dye; and a strong binding process effected by both electrostatic and Van der Waals interacti... | 308,053 | [
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Early detection of occlusal caries by measuring the electrical resistance of the tooth. | The tooth resistance measuring instrument was compared to the traditional method of the explorer examination for the detection of occlusal carious lesions. The findings of the instrument were more sensitive as compared to the traditional method when verified by a histological examination. | 308,070 | [
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Triggering of cultured neoplastic mast cells by antibodies to the receptor for IgE. | Cell surface receptors for IgE were isolated from detergent lysates of iodinated, IgE-saturated, rat basophilic leukemia cells by precipitation with anti-IgE antibodies followed by chromatography at acid pH. The isolated material showed a single 125I-band (m.w. approximately 58,000) on gel electrophoresis in sodium dod... | 308,073 | [
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Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. | NZB/NZW F1 mice of both sexes were castrated at 2 wk of age and implanted subcutaneously with silastic tubes containing either 5-alpha-dihydrotestosterone or estradiol-17-beta. Mice receiving androgen showed improved survival, reduced anti-nucleic acid antibodies, or less evidence of glomerulonephritis as determined by... | 308,087 | [
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In vitro induction of cytotoxic effector cells with spontaneous killer cell specificity. | The present work shows that stimulation of peripheral blood lymphocytes with autologous or allogeneic B-cell lines leads to a strong induction of cytotoxic effector cells with spontaneous killer (SK) cell specificity, apart from the specific response directed against the particular stimulating cell. To demonstrate this... | 308,088 | [
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Degradation and clearance of methotrexate in children with osteosarcoma receiving high-dose infusion. | Plasma methotrexate (MTX) concentrations were quantitated in 34 patients after 127 high-dose (35--350 mg/kg) infusions with citrovorum factor rescue. Significant linear correlations have been obtained between methotrexate dosage and concentrations in plasma at 6 and 24 hours after the initiation of the therapy. However... | 308,151 | [
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The initial management of simple febrile seizures. | One hundred consecutive cases of simple febrile seizures in childhood were studied. Seventeen of these children had had more than one seizure during the febrile episode, but none of the patients had a further seizure after treatment with simple antipyretic measures. Thus it appears unnecessary to give anticonvulsants t... | 308,210 | [
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[Biorheologic study of pathological synovial fluids]. | Rheometric studies of 34 synovial fluids done using a rheometer with a cone and stage (Shirley-Ferranti type) showed that arthrotic synovial fluids had pseudoplastic characteristics (non-Newtonian) but in inflammatory rheumatisms, the characteristics index rises, the consistency decreases and the fluid tends to loose i... | 308,251 | [
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beta-lactamases and R-plasmids of Haemophilus influenzae. | The emergence of resistance to ampicillin and other antibiotics in Haemophilus influenzae has been a relatively recent event. In contrast, drug resistance has been rampant in the Enterobacteriaceae for many years. Ampicillin-resistance in H. influenzae is almost invariably attributable to possession of the TEM (Type II... | 308,259 | [
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The effects of methylprednisolone on the complications of coronary artery surgery. | Complications of coronary artery surgery were analyzed in a prospective controlled study of 150 patients, one group receiving methylprednisolone before temporary cardiopulmonary bypass. The patient population was comparable in both the groups. The number of deaths were the same in both the groups, myocardial infarction... | 308,283 | [
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Central thickness in corneal disorders. | In the single individual the central corneal thickness (CCT) shows only small variations. Therefore CCT has been studied in a number of corneal diseases in order to investigate if this dimension might contribute to the diagnosis or to the understanding of the pathogenesis. Normal CCT was found in hereditary dystrophies... | 308,291 | [
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Mechanism of tolerance to DNCB-contact sensitivity induced by immunosuppressive agents. | Specific unresponsiveness to DNCB contact sensitivity has been induced in guinea pigs by a combined application of two immunosuppressive agents, cyclophosphamide and antithymocyte serum, to guinea pigs during the period of sensitization with DNCB. This tolerance was specific since the reactivity to an unrelated hapten ... | 308,299 | [
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Immune competence in patients with Klinefelter syndrome. | We studied cellular and humoral immunity on ten patients with documented Klinefelter syndrome. Cellular immunity as measured by in vivo skin tests and in vitro lymphocyte transformation tests appeared intact. However, the mean values of T cells and EAC rosette-forming cells were significantly decreased as compared with... | 308,318 | [
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[The effect of the pupil as aperture and field stop on the various components of the human electroretinogram (author's transl)]. | The electroretinogram (ERG) was recorded in 10 normal subjects under scotopic and photopic conditions with the pupil of one eye constricted and that of the other eye dilated. The human iris, being displaced from the nodal point of the eye, acts not only as an aperture, regulating the retinal illumination, but also as a... | 308,328 | [
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Treatment of alopecia areata with dinitrochlorobenzene. | Persistent refractory alopecia areata in 26 patients was treated topically with dinitrochlorobenzene (DNCB). Sixteen patients have had excellent regrowth of hair; three patients could either not be initially sensitized or an adequate allergic contact dermatitis on the scalp did not develop. Two patients discontinued th... | 308,348 | [
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Coronary surgery for unstable angina pectoris. Incidence and mortality of perioperative myocardial infarction. | The incidence of perioperative myocardial infarction determined by electrocardiogram was examined in 123 consecutive patients having only coronary artery bypass grafting for unstable angina pectoris, at Yale-New Haven Hospital from January 1974 to June 1975. The incidence of myocardial infarction and its mortality were... | 308,374 | [
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Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo. | Aprotinin was bound and endocytosed by Landschütz ascites carcinoma (LAC) cells in vitro. Addition of the antiprotease to cultures of these cells led to a dose-dependent growth-inhibitory and cytotoxic effect. In mice inoculated with LAC cells and treated with aprotinin there was a transient reduction in both the numbe... | 308,375 | [
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Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine. | The serotonin precursor, 5-hydroxytryptophan (5-HTP), can induce a behavioral syndrome characterized by rigidity, splayed feet, tremor, head weaving, salivation and forepaw treading. This response to 5-HTP was markedly potentiated in adult rats treated intracisternally with 5,7-dihydroxytryptamine (5,7-DHT) during deve... | 308,387 | [
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T cell-dependent suppression of antibody production. I. Characteristics of suppressor T cells following tolerance induction. | Specific immunological tolerance was induced in adult CBA mice by a single injection of deaggregated human IgG (dHGG). Spleen cells taken 7 to 42 days later, produced consistent suppression of a DNP-HGG collaborative antibody response on adoptive transfer into heavily irradiated recipients. Noncentrifuged F(ab')2 fragm... | 308,454 | [
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Response characteristics of semicircular canal and otolith systems in cat. II. Responses of trochlear motoneurons. | 1. The electrical activity of single trochlear motoneurons (TMns) and axons of second order vestibular neurons presumably terminating on these motoneurons were studied during natural stimulation of semicircular canals and otolith organs in cats anesthetized with Ketamine. 2. Null point analysis showed that TMns receive... | 308,465 | [
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Vertebral compression syndrome in multiple exostoses (case report). | The authors present a case, the second in the world literature, of Spinal Compression Syndrome in Multiple Exostoses. The diagnosis, not revealed on standard radiographs of the vertebral column, was suspected on radiculography and confirmed only by oblique stratigraphic projection. These demonstrated bone formation on ... | 308,497 | [
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-0.02277779,
-0.1741465,
-0.1013072,
-0.1529414,
-0.1052777,
-0.2076104,
0.09658988,
0.06969603,
-0.4039223,
0.2589769,
0.2312676,
-0.04905666,... |
Evidence for changes in segmental motoneurone pools by chronic cerebellar stimulation and its clinical significance. | Electrophysiological studies in eight patients with severe motor system abnormalities are described both before and after the start of chronic electrical stimulation of the anterior cerebellum. With stimulation, at least one of following changes was found in seven of these eight patients: reversal of abdominal F amplit... | 308,528 | [
-0.03215843,
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0.1067994,
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0.04390969,
0.291706,
0.01467307,
0.07282469,
-0... |
Relapsing neuropathy due to tetanus toxoid. Report of a case. | A unique case history is presented, of a 42-year-old patient who has suffered three episodes of a demyelinating neuropathy, each of which followed an injection of tetanus toxoid. The clinical features on each occasion were characteristic of acute idiopathic polyneuropathy; a rapid onset of a mainly motor neuropathy wit... | 308,529 | [
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0.08988857,
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0.06599487,
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0.1274472,
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0.01592611,
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0.02443923,
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0.689867,
0.00... |
Effect of TMP-SMX on nasopharyngeal carriage of ampicillin-sensitive and ampicillin-resistant hemophilus influenzae type B. | The carriage rate of ampicillin-resistant Hemophilus influenzae type B in a chronic care facility was investigated. Up to 48% of the children carried this strain. Of interest was the finding of simulaneous carriage of ampicillin-resistant and ampicillin-sensitive HITB, a phenomenon which was detected by using both choc... | 308,533 | [
0.01819321,
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0.1017861,
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0.1130894,
0.4537283,
0.09594755,
0.1695938,
-0.1... |
Maintenance of low sodium and high potassium levels in resting muscle cells. | 1. Previous work has shown that a frog sartorius muscle consists of parallel cells running all the way from one end of the muscle to the other and that amputation of one end of the muscle is not followed by regeneration of a new cell membrane. If now only the cut end of the amputated muscle is exposed to a Ringer solut... | 308,536 | [
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0.1629823,
0.3282696,
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0.03544742,
... |
Reversible depletion of synaptic vesicles induced by application of high external potassium to the frog neuromuscular junction. | 1. Reversible depletion of synaptic vesicles from frog cutaneous pectoris neuromuscular junctions was studied by application of a Ringer solution containing 115 mM-K propionate.2. During the release of transmitter, the synaptic vesicle membrane is added to the axolemmal membrane. Under the conditions of high K(+)-induc... | 308,538 | [
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0.3133436,
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0.4102807,
0.2303107,
0.076... |
Treatment of hereditary angioedema. | The purpose of this study was to report the results of different treatments in 20 patients with hereditary angioedema. Effectiveness of tranexamic acid in preventing swellings was evaluated in 15 patients: in all but 3 subjects tranexamic acid was effective without serious side effects. 15 severe attacks of edema were ... | 308,574 | [
-0.02190845,
0.1490726,
0.002027046,
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0.1019926,
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0.2893557,
0.01066736,
0.4041962,
-0.03196863... |
Serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with hereditary rickets or bone disease. | The serum concentration of 1,25-dihydroxylvitamin D (1,25-[OH]2D) in normal children and in children with inherited diseases of bone was compared by use of a competitive binding assay. Observed values were: in 12 normal children and adolescents, 37.1 +/- 1.9 pg per milliliter (mean +/- S.D.); in 14 patients with X-link... | 308,618 | [
-0.487338,
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0.1317912,
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0.2264215,
0.4547904,
0.3676782,
-0.1003168,
... |
Chlordiazepoxide-fluoxetine interactions on food intake in free-feeding rats. | Chlordiazepoxide, which blocks serotonin turnover, increased food intake; and fluoxetine, a serotonin agonist, decreased food intake. Administration of combinations of the two drugs showed an antagonistic dose-dependent relationship, implicating a satiety of hunger mechanims which is mediated by serotonin. | 308,664 | [
-0.270429,
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... |
[Effect of phytohemagglutinin on T-lymphocytes isolated from human blood]. | T--enriched lymphocyte fraction from normal donors was isolated from heparinized peripheral blood on Ficoll-Urotrast gradients. The mitogenic response of T-lymphocytes in culture was 3 times as high as that of unseparated mononuclear cells. The intensity of blast transformation to PHA did not correlate with the increas... | 308,719 | [
-0.04370667,
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0.02811898,
0.00009596414,
0.2212181,
0.4606496,
0.08720461,
-0.06396032... |
Congenital achromatopsia in a Finnish family. | A family with two achromatic members, a sister and brother, is described. Their parents were first cousins. Eye examination of the 34 relatives examined revealed no abnormalities in 32. The son of their youngest brother was deuteranomalous. However, since this recessive trait is X chromosome linked, this failure was no... | 308,762 | [
-0.08396965,
0.2290011,
0.02078841,
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0.3191431,
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0.2521046,
-0.2334462,
-0.4489716,
0.2324159,
0.1724799,
-0.1286... |
Heterotypic protective immune reactions in mice infected with distinct serotypes of human influenza virus. | Infection of mice with subtype A0 OR A2 human influenza viruses, by a non-respiratory route causing no lethality, renders the animals markedly resistant to subsequent respiratory challenge with a strain differing from the first one through its haemagglutinin and neuraminidase antigens. This state of heterotypic immunit... | 308,787 | [
-0.1218159,
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0.1822419,
0.2043196,
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... |
Immunological abnormalities in bronchiectasis with chronic bronchial suppuration. | Fifty-three patients with bronchiectasis (chronic bronchial suppuration) of unknown cause, in whom the chronic production of purulent sputum was the prominent clinical feature, were investigated for possible immunological abnormalities. They were compared with two control groups comprising 50 patients with chronic bron... | 308,809 | [
0.187768,
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0.1906497,
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0.03848968,
0.01163185,
0.2562695,
0.04038416,
0.0337146,
-0.0... |
Cancer, pancreatitis, and the detection of the isoenzymes of DNAase, RNAase and amylase. | Substrate films of starch, RNA, and DNA were used to identify the isoenzymes of amylase, RNAase, and DNAase found in human ductal pancreatic juice subjected to isoelectric focusing. The pancreatic secretions from 15 patients were shown to contain as many as four isoenzymes of RNAase; the two major forms had isoelectric... | 308,871 | [
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0.006035388,
0.04594135,
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0.3358072,
0.1115508,
-0.100740... |
Seasonal variations in fat body metabolism of the green frog Rana esculenta (L.). | Rana esculenta (L.), kept under natural conditions, show almost constant body weights in the annual cycle. Fat body weight, however, has a distinct maximum in October decreasing continuously to a May minimum which is also evident in the fat body index. The triglyceride and protein contents show the same course. Suprisi... | 308,886 | [
0.1160406,
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0.2900928,
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0.3385494,
-0.3016... |
[Immunosuppression by means of cytostatic chemotherapy. Inhibition of antibody formation and induction of tolerance in animal experiments]. | Two different experimental models are presented for the induction of immunosuppression and immunological tolerance in mice with antineoplastic drugs: a) an unspecific T cell activation with a phytomitogen (phytohemagglutinin), or b) a partial synchronization of antigen-induced proliferation by mitotic blockade with vin... | 308,923 | [
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0.3995386,
0.3151725,
0.08241952,
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... |
Mitogenic factor from chronically infected guinea pigs. | A lymphokine produced by antigen stimulated lymphocytes, induces blastogenesis in cultures of lymphocytes which are not sensitive to the specific antigen. The in vitro production of this factor (MF) was accomplished utilizing peritoneal exudate (PE) cells from Coccidioides immitis infected guinea pigs. Production of MF... | 308,928 | [
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0.1103798,
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0.4537025,
0.3442617,
0.09956895,
-0.3965084... |
The effect of passive immunization against tetanus toxoid in man. | The present study deals with the immunological response in man after passive immunization against tetanus toxoid. Treatment of man with equine antitetanus serum stimulates a rise of E rosette-forming T lymphocytes. The level of IgG also rises while the level of IgM falls. It is assumed that the foreign globulin acts as... | 308,931 | [
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0.1781505,
0.3660817,
0.2552368,
-0.03280824,
... |
Nonuniform distribution of concanavalin-A receptors and surface antigens on uropod-forming thymocytes. | Uropods can form spontaneously in a variable fraction of mouse thymocytes incubated for 30--60 min in vitro at temperatures between about 8 degrees and 37 degrees C. The majority of the cells with a typical uropod are medium and large thymocytes. The "normal" distribution of concanavalin-A receptors and antigens recogn... | 308,949 | [
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Regulation of delayed-type hypersensitivity reactions by cyclophosphamide-sensitive T cells. | The onset, intensity, and duration of DTH reactions elicited in mice immunized with either SRBC or products of the major histocompatibility complex can be altered significantly by pretreatment with CY 1 to 2 days before immunization. Such drug pretreatment tends to augment low DTH responses caused by the use of too muc... | 308,970 | [
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0.1995833,
0.1071277,
0.2442455,
0.04191491,
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Specific suppressive factors produced by hybridomas derived from the fusion of enriched suppressor T cells and a T lymphoma cell line. | A cell fusion technique was used to produce hybridomas between the T lymphoma cell line, EL-4, derived from C57BL (H-2(b)), and an enriched population of human gamma globulin (HGG)-specific suppressor T cells prepared from the spleens of HGG-tolerant CBA mice (H-2(k)). Membrane fluorescence analysis of the hybridoma ce... | 308,978 | [
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0.09671348,
0.4793282,
0.4242616,
-0.070566... |
Regression and inhibition of sarcoma growth by interference with a radiosensitive T-cell population. | BALB/c mice were inoculated subcutaneously with 10(6) cells from either of two syngeneic sarcomas 1315 and 1425. 6--8 days later, the mice were randomized into groups which were left untreated or given 400 rads of whole body irradiation. Irradiation significantly retarded the growth of both sarcomas, and complete regre... | 308,987 | [
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0.4857931,
0.1132883,
0.2333284,
-0.006... |
Homozygous alpha1 antitrypsin deficiency with unusual associations: a case report. | The rare association of protease inhibitor deficiency (Pi(zz) genotype) in a black American with chronic, obstructive pulmonary disease due to asthmatic bronchitis, rather than basal pan lobular emphysema, is presented. The late onset of symptoms, despite environmental exposures, is also unusual in this homozygote, as ... | 309,010 | [
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0.3300787,
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0.5088068,
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-... |
Painful joints. Clues to early diagnosis. | Many cases of joint pain may be diagnosed from clinical findings alone. A careful history and physical examination are essential. Of all diagnostic laboratory tests for joint disease, none is completely specific. Results of latex fixation tests, antinuclear antibody (ANA) tests, and uric acid tests are all strongly sug... | 309,126 | [
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0.1056328,
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0.1269152,
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0.2404153,
0.3829651,
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-0.26624,
0.090... |
Detection of hemorrhage in a patient with cecal varices using 99mTc-sulfur colloid. | Colonic or ileal varices secondary to portal hypertension or superior mesenteric vein obstruction may present with significant hemorrhage which is difficult to diagnose by angiography. In a patient with lower gastrointestinal hemorrhage and colonic varices, a 99mTc-sulfur colloid scan demonstrated the varices and extra... | 309,142 | [
-0.2117948,
0.2038468,
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0.1401258,
0.1958886,
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0.005431565,
-0.023320... |
Immune status in Crohn's disease. I. Leukocyte and lymphocyte subpopulations in peripheral blood. | Proportions and absolute numbers of circulating leukocyte populations and lymphocyte subpopulations (T- and B-cells) were determined in 33 patients with Crohn's disease (group CD), and were compared with those of age- and sex-matched healthy subjects. Group CD comprised 15 patients with newly diagnosed, short-standing,... | 309,171 | [
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0.04707027,
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0.2430547,
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0.1308527,
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0.1416423,
0.2478103,
0.3463281,
0.2775223,
0.4694531,
-0.126866,
-0.242... |
Peroperative endoscopic diagnosis of small intestinal bleeding. | Two patients with recurrent bleeding from vascular anomalies in the small intestine are described. In both patients intestinal angiography had shown either pathological vessels or extravasation of blood into the proximal part of jejunum, but during explorative laparotomy the source of bleeding had not been found. The d... | 309,172 | [
-0.1957792,
0.05767851,
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0.192913,
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0.390352,
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0.07791338,
0.1002948,
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0.1223498,
0.1338276,
-0.01103098,
... |
Heparin neutralizing activity in patients with renal disease on maintenance haemodialysis. | Heparin neutralizing activity (HNA) was increased in plasma of patients with end-stage renal disease treated by maintenance haemodialysis. It was not raised in non-dialyzed patients with chronic renal failure, nor in patients with normal renal function who had been exposed to the extracorporeal circulation of the heart... | 309,192 | [
-0.08908784,
0.11404,
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0.1202005,
0.02059689,
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0.2624314,
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0.08221806,
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0.04322812,
0.1760006,
0.2881545,
-0.01373828... |
Acute electrical stimulation for urinary incontinence. | Acute or maximal electric stimulation of the pelvic floor muscles has been used in incontinent patients who are suitable candidates for electrical stimulation, but unwilling or unable to use the anal plug electrodes. Seventeen of 20 patients had relief or improvement of their incontinence. However 5 of these 17 patient... | 309,207 | [
-0.005665467,
0.09867394,
-0.2489943,
-0.1637867,
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-0.195959,
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0.2020993,
-0.107994,
-0.07218365,
-0.03734783,
-0.3438842,
-0.1725764,
-0.3684686,
0.1461717,
-0.1090721,
-0.4085829,
0.001883664,
0.05570167,
0.1383336... |
Placebo effect in the treatment of angina pectoris. | The interference of placebo effect in the treatment of angina pectoris has been studied in a group of patients with stable angina pectoris, selected on the basis of normal electrocardiogram at rest and a pathologic ergometric electrocardiographic test. It was found that the patients could be divided, according to the r... | 309,264 | [
-0.1151252,
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0.3007258,
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0.268649,
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... |
Aortoduodenal fistula: role of endoscopy in diagnosis. | A patient with an aortic by-pass graft presented with intermittent gastrointestinal bleeding. A definitive diagnosis of an aortoenteric fistula involving the third part of the duodenum was made at endoscopy. Diagnosis of an aortoenteric fistula is often difficult with angiography and barium contrast studies, frequently... | 309,280 | [
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0.262743,
0.03933008,
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... |
Safety and efficacy of chronic cerebellar stimulation. | It is our conclusion that CCS is both efficacious and safe as a therapeutic measure for neurologic disease. As indications become more concise and patients can be chosen who are not as incapacitated as those in our first group, this should become even more apparent. In order to be certain that calibration of the stimul... | 309,307 | [
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0.1027... |
Control of spasticity and involuntary movements--cerebellar stimulation. | By stimulating the medial aspect of the superior surface of the cerebellum with relatively short, low current stimulating pulses, spasticity and some involuntary movements have been reduced. Voluntary movements, as a result, are able to come through better; however, if the child has little voluntary ability, he is at l... | 309,308 | [
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0.1149745,
... |
Chronic dorsal column stimulation via percutaneously inserted epidural electrodes. Preliminary results in 31 patients. | 31 patients suffering from intractable pain associated with chronic low back syndrome, terminal cancer, and other disorders have been studied after an average 6 months' treatment by electrical stimulation of the spinal cord applied via electrodes inserted through a Tuohy needle into the epidural space. As judged by thr... | 309,310 | [
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Electrostimulation of the nervous system for patients with demyelinating and degenerative diseases of the nervous system and vascular diseases of the extremities. | The results of electrostimulation of the spinal cord for symptoms other than that of pain are recorded in this publication. 50% of patients with multiple sclerosis, primary lateral sclerosis and hereditary spino-cerebellar disorders were observed to have enduring favourable changes in neurological function during the 1... | 309,312 | [
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0.3357911,
0.09486131... |
PABA screening test for exocrine pancreatic function in infants and children. | P-Amino-benzoic acid (PABA) is split specifically by pancreatic chymotrypsin from the synthetic tripeptide N-benzoyl-L-tyrosyl-PABA. The urinary excretion of absorbed PABA serves as an index for exocrine pancreatic function. The peptide (0.015 g/kg) was administered orally to 20 controls (aged between 5 months and 16 y... | 309,317 | [
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0.2182292,
0.0643383,
... |
Stimulation of in vitro granulocyte--macrophage colony formation by mouse heart conditioned medium. | Medium conditioned by mouse heart tissue was found to contain colony-stimulating factor(s) (CSF) which produced in vitro colonies of granulocytes and/or macrophages with bone marrow cells of CBA mice. The action of this CSF type (CSFMHCM) was compared with that of post-endotoxin mouse serum (CSFES on colony formation b... | 309,338 | [
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0.1357156,
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0.1496025,
... |
Modulation of the primary electron transfer rate in photosynthetic reaction centers by reduction of a secondary acceptor. | Photosynthetic application of picosecond spectroscopic techniques to bacterial reaction centers has led to a much greater understanding of the chemical nature of the initial steps of photosynthesis. Within 10 ps after excitation, a charge transfer complex is formed between the primary donor, a "special pair" of bacteri... | 309,343 | [
-0.1089967,
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0.144836,
0.2549785,
0.2421662,
0.04772432,
... |
Histoplasma capsulatum infection in nude mice. | Congenitally athymic nude (nu/nu) mice, when injected intraperitoneally with Histoplasma capsulatum, developed a rapidly fatal disseminated infection characterized by heavy parasitization of reticuloendothelial tissues. In contrast, their heterozygous (nu/X) littermates, which possessed a functioning thymus, developed ... | 309,438 | [
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0.0123496,
0.09207495,
0.0761436,
0.4447218,
0.04175197... |
The r.b.e. of different-energy neutrons as determined by human bone-marrow cell-culture techniques. | The effect of X-rays and different-energy neutrons on human bone-marrow cells was studied using two different cell-culture techniques--diffusion chamber (DC) growth and colony formation in vitro (CFU-C). Based on the survival of proliferative granulocytes in DC on day 13, the D0 value was 80 rad with X-rays, and 117 ra... | 309,448 | [
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0.3288783,
0.1023073,... |
[Giant hypertrophy of the gastric antrum (localized Menetrier's disease) as a cause of recurrent intestinal hemorrhage]. | A case of discrete, localised Morbus Ménétrier is reported, with pitting of a giant mucosal fold at the antrum, where the patients' main symptom was recurrent gastric haemorrhage. The presentation posed considerable diagnostic difficulties that were only clarified through a partial gastric resection and subsequent hist... | 309,460 | [
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-... |
HLA-B27, antinuclear antibodies and drug-induced agranulocytosis. | Eight female patients with drug-induced agranulocytosis (five patients with definite seropositive rheumatoid arthritis (RA), three patients with upper respiratory infections) were studied for the presence of HLA-B27 and antinuclear antibodies (ANA). Five of eight patients were found to be HLA-B27 positive and all RA pa... | 309,534 | [
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0.05956582,
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Bulging (sagging) fissure sign in Hemophilus influenzae lobar pneumonia. | A bulging fissure sign was noticed on chest roentgenogram in a patient with H influenzae pneumonia. This sign is usually associated with Klebsiella pneumonia and has also been seen in pneumococcal and plague pneumonia, tuberculosis, mass lesions of the lung, and large lung abscesses. This is thought to be the first rep... | 309,660 | [
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0.4267582,
0.002611931,
0.012517... |
[Pathogneses of cutaneous malignant lymphoma]. | In 1974 we suggested a schedule of the pathogenesis of CML. CML was described as a variant of the cutaneous lymphadenoid infiltrate (Fig. 2). Four years later, the schedule still appears to be valid, even to explain the three types of pseudolymphoma (Table 3). Recent findings concering. Burkitt's lymphoma and Mycosis f... | 309,693 | [
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0.2049778,
0.05188678,
0... |
Radionuclide assessment of ventricular performance during propranolol withdrawal prior to aortocoronary bypass surgery. | The effects of oral propranolol upon left ventricular performance were assessed in 18 patients with angiographically documented coronary artery disease in whom propranolol was tapered prior to elective aortocoronary bypass surgery. Left ventricular ejection fraction, ejection rate, and regional wall motion were obtaine... | 309,716 | [
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0.1186896,
0.2795996,
0.226566,
0.06537287,
0.05515356... |
Giant cell carcinoma of the pancreas. Report of a case with upper gastrointestinal bleeding diagnosed by endoscopic brush cytology. | A case of upper gastrointestinal bleeding as the first and only manifestation of giant cell carcinoma of the pancreas invading the duodenum is described. The polypoid tumor was visualized during endoscopy. The diagnosis was made by a cytologic brush and confirmed by endoscopic biopsy. The rather uncommon presentation o... | 309,721 | [
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0.02945437,
-... |
Human pancreatic alpha-amylase: phenotypic codominance and new electrophoretic variants. | The genetic heterogeneity of human pancreatic alpha-amylase (alpha-1,4-glucan 4-glucanohydrolase, E.C. 3.2.1.1) has been better defined through the development of an asparagine buffered electrophoretic gel system. Three alleles had been identified for the pancreatic amylase locus, AMY2, with two variant alleles as auto... | 309,725 | [
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An increase in intraocular pressure due to clonidine. | The rise in intraocular pressure (IOP) observed after the administration of clonidine into the carotid arteries was studied in anesthetized rats and cats. This increase of IOP proved to be blocked by the alpha-sympathicolytic agent piperoxane and by the muscle relaxants d-tubocurarine and gallamine. Our experiments sug... | 309,734 | [
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0.039... |
[In vitro incubation of lenses. Model for testing substrate utilization of substances of the energy metabolism, demonstrated with bencyclane-hydrogen-fumarate (author's transl)]. | When bovine lens homogenate was treated with bencyclane-hydrogen-fumarate, the carbohydrate metabolism was activated. This may chiefly be due to the fumarate part of the substance. A 24 H In vitro incubation of whole bovine lenses in TC-199 with and without bencyclane-hydrogen-fumarate did not show the above effect. On... | 309,736 | [
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0.4408753,
0.2801374,
0.3077296,
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... |
Cockayne's syndrome and emphysema. | A 5-year-old boy with Cockayne's syndrome is described. In addition to the recognised clinical features, he presented with severe fixed airways obstruction, and investigations confirmed clinical and physiological emphysema. In a disorder associated with many of the features of aging, it is probably that the presence of... | 309,750 | [
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0.07634361,
0.04081804,... |
Vestibular toxicity of gentamicin. Incidence in patients receiving long-term hemodialysis therapy. | Twenty-three patients on long-term hemodialysis regimens who received gentamicin sulfate were reviewed retrospectively to assess the incidence of ototoxicity and to identify potential risk factors. Dosage of gentamicin sulfate was 1.0 to 1.5 mg/kg intravenously three times weekly. Serum gentamicin levels were monitored... | 309,753 | [
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0.04156037,
0.2661965,
0.2509396,
... |
Monoamine metabolism during bicuculline-induced epileptic seizures in the rat. | Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicuculli... | 309,780 | [
-0.07098303,
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0.2164422,
0.1013341,
0.1322173,
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0.5329728,
-0.0349860... |
T- and B-lymphocyte subpopulations in the tropical splenomegaly syndrome (TSS). | Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the perc... | 309,810 | [
0.205211,
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0.2976314,
0.09019609,
0.01439991,
-0.3... |
Studies on the host-parasite relationship in Schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion. | CBA mice deprived of their T cells by means of thymectomy and anti-thymocyte serum and subsequently infected with Schistosoma mansoni were found to have substantially fewer parasite eggs in their faeces than similarly infected immunologically-intact control animals. The number of parasite eggs deposited in the tissues ... | 309,856 | [
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0.3263439,
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0.1725442,
-0.... |
The sidewinder catheter for extra cranial angiography: technical, diagnostic and therapeutic applications. | Through using the sidewinder catheter system for visceral angiography in over 200 patients we have improved our success rate. The method is simple and safe, and we recommend it. | 309,885 | [
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0.07055828,
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A histochemical study on the innervation of cerebral blood vessels in the bullfrog. | Specific histochemical techniques for the demonstration of catecholamine and acetylcholinesterase have been used to study the distribution of adrenergic and cholinergic nerves on the cerebral blood vessels of bullfrog, Rana catesbeiana. The adrenergic nerve meshworks on the cerebral arteries of bullfrog were less dense... | 309,891 | [
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0.02933384,
-0.1361... |
Visualization of intracellular concanavalin A binding sites in retinal photoreceptors. | Localization of carbohydrate components in retinal photoreceptor cells and membranes was studied. Frog and rat retinas were fixed with glutaraldehyde and embedded in glycol methacrylate or in a mixture of glycol methacrylate, glutaraldehyde and urea. Thin sections were incubated with ferritin-labeled concanavalin A (F-... | 309,892 | [
0.01324581,
-0.01327299,
-0.1197753,
0.1269722,
0.0990696,
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0.1049998,
0.04786082,
0.09494217,
0.3524155,
0.1234507,
0.2425713,
0.03717355,
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0.1593851,
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0.01324661,
0.1441513,
-0.2916421,
0.3480377,
0.1860234,
0.001269994,
-... |
Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes. | Successful induction of in vitro differentiation and immunoglobulin synthesis of the leukemic lymphocytes was carried out in two cases of chronic lymphocytic leukemia. Few plasma cells and little specific Ig secretion were detected in the cultures of isolated leukemic B cells in either the presence or the absence of au... | 309,923 | [
-0.1917987,
-0.2134249,
-0.3627018,
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0.3248752,
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0.2549323,
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0.3201605,
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0.3946953,
0.1194325,
0.2188477,
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0.03949043,
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0.3243069,
0.5690088,
0.3992635,
-0.02945883,
0... |
In vitro generation of antigen-specific helper T cells that collaborate with cytotoxic T-cell precursors. | Antigen-specific helper T cells are required in the generation of cytotoxic T cells from thymocyte precursors. We have demonstrated that these alloantigen-specific helper cells can be generated in vitro and that both the quantity and quality of the helpers appear to be superior to the help obtained from unprimed spleen... | 309,924 | [
0.03279498,
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0.1570561,
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0.1399537,
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0.01975124,
0.08067992,
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0.1649351,
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-0.09482098,
-0.1792508,
0.4298668,
0.269257,
0.1559141,
0.1050408,
... |
B-cell precursors specific to sheep erythrocytes. Estimation of frequency in a specific helper assay. | A sensitive, specific, and reproducible in vitro helper assay is described which is suited to limiting dilution analysis of murine B cells. 1 in about 3,000 syngeneic splenic B cells can be induced to form plaque-forming cells (PFC) to sheep erythrocytes in this system. The induction of PFC is absolutely dependent on a... | 309,925 | [
-0.05699245,
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0.14332,
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0.1052297,
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0.2955779,
0.2098239,
0.2993129,
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0.09626274,
0.03542789,
0.5327303,
0.3211487,
0.2365346,
0.2507857,
-0.2081... |
Fever and survival in rabbits infected with Pasteurella multocida. | 1. Fever and survival rate of New Zealand white rabbits, injected with two doses of live Pasteurella multocida, were compared to determine if the relation between fever and survival observed in reptiles is also seen in a mammal. Since it is known that fever is beneficial in infected reptiles, our experiments were viewe... | 309,939 | [
0.07438523,
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0.1039407,
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0.08746856,
0.0573836,
0.1405296,
0.6396437,
0.4961993,
0.06518322,
-0.3119041,
... |
How should one investigate the posterior fossa? | The case notes of 170 consecutive patients with a suggestive clinical history, or a proven final diagnosis of a posterior fossa lesion have been analyzed in order to determine the precise value of each radiological investigation. All had had CT scans. The patients have been grouped clinically according to their present... | 310,085 | [
-0.1281991,
0.1950761,
0.01828936,
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0.08255162,
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0.09150724,
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0.1143867,
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-0.1754589,
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0.05900934,
0.2481816,
-0.1179949,
0.3432956,
0.1813863,
0.03266769,
0.00906898... |
Treatment of pain by transcutaneous electrical stimulation. | Two hundred and ninety-two patients suffering from a wide range of pain syndromes were treated with transcutaneous electrical stimulation (TES). Electrical stimulation of the painful area was administered on the skin by externally applied electrodes, attached to a portable battery-operated apparatus. The results, deter... | 310,231 | [
0.03083369,
0.2878783,
0.02338561,
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0.08075974,
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0.1407126,
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-0.5270413,
-0.009041652,
-0.1593883,
-0.1923304,
0.122213,
0.01574297,
-0.12198... |
Studies on the pseudo-exfoliation material: a review. | Pseudo-exfoliation (PE) material may be found on several surfaces of the anterior segment of the eye. The material contains typical cross-banded PE fibrils distributed at random. These fibrils have been studied with transmission and scanning electron microscopy. Negative staining of dispersed PE fibrils indicated that ... | 310,264 | [
-0.118517,
0.09319496,
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0.1896261,
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0.1323357,
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0.3276978,
0.2824904,
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0.2243337,
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0.1238099,
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0.3255967,
0.06822899,
-0.2135986,
0.2372539,
0.2130665,
0.06663734,
-0... |
Human leukocyte and fibroblast interferon in a combination therapy of dendritic keratitis. | Thirty-eight patients with virologically proven dendritic keratitis were treated using either debridement plus human leukocyte interferon (HLI) or debridement plus human fibroblast interferon (HFI) in a randomized, double-blind study. We administered one drop of HLI or HFI (1 X 10(6) reference units/ml) daily and found... | 310,269 | [
-0.1705304,
0.2855424,
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0.0344989,
0.3923996,
-0.5772874,
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0.1460611,
0.08084013,
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0.03262931,
-0.04208849,
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-0.1703511,
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-0.2611588,
-0.01333802,
0.07323799,
-0.4007004,
0.3742494,
0.02697488,
0.1959704,
0.1447645,
... |
Orbital volume after enucleation and eye volume in the adult rabbit. | Of 21 mature, fully grown Dutch rabbits, seven were controls separated into two groups in which eye and orbital volumes were determined at 10 and at 18 months of age respectively. In the 14 remaining rabbits, enucleation of one eye was done at 10 months of age. Immediately afterward the eye volume was determined. These... | 310,271 | [
-0.0507882,
0.09373229,
-0.3239805,
-0.223366,
0.02219558,
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0.09027012,
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0.01005123,
-0.1438331,
0.3199563,
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-0.03643751,
0.3955747,
0.3108235,
-0.05531612,
-0.1206811,
0.2878387,
-0.0375430... |
Subcutaneous transposition of the spleen: a method for treatment of complications in portal hypertension? | Eleven patients with portal hypertension were treated with subcutaneous transposition of a resected spleen. In eight of the patients the operation was performed after variceal bleeding. In this group there was one operative mortality--a 77-year-old woman. Another patient died after 28 months in upper gastrointestinal b... | 310,286 | [
-0.08857594,
-0.07231583,
-0.4451609,
-0.3069642,
-0.01390706,
-0.30185,
0.1556984,
0.03404629,
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0.05454599,
0.3752711,
0.1978779,
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0.07832047,
-0.1315562,
-0.1085179,
0.3045628,
0.3066404,
0.55026,
-0.08289298,
... |
Homology of single copy and repeated sequences in chicken, duck, Japanese quail, and ostrich DNA. | The extent of reassociation of 3H-labeled repetitive or single copy DNA sequences from the chicken with excess unlabeled DNA from the duck, the Japanese quail, and the ostrich, respectively, was measured by hydroxylapatite chromatography. Chicken repetitive DNA reassociated to an equal or greater extent than chicken si... | 310,314 | [
-0.1208891,
0.02732841,
0.009838038,
0.02492883,
0.08818709,
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0.1285097,
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0.2624788,
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0.03033796,
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0.09215755,
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0.09520307,
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0.09104688,
0.2633877,
-0.1613893,
0.3690249,
-0.1445527,
-0.2606... |
The fucosyl specific lectins of Ulex europaeus and Sarothamnus scoparius. Biochemical characteristics and binding properties to human B-lymphocytes. | From the seeds of the gorse, Ulex europaeus and of the broom, Sarothamnus scoparius L-fucosyl-specific lectins were isolated by affinity chromatography on L-fucosyl-epoxy-Sepharose. The lectins showed similarities in their molecular weights, amino acid composition, carbohydrate content and in the finger-prints of their... | 310,317 | [
0.01395588,
-0.01780189,
-0.1598032,
0.03980094,
0.1855519,
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0.2717774,
0.2285434,
0.5775314,
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0.0543059,
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0.1499703,
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0.00275499,
0.08606851,
-0.0273195,
0.3786816,
0.3851143,
-0.3708842,
-0... |
[Effect of acetylcholine on the firing rate and action potential shape of pacemaker cells]. | A study was made of the action of exogenous acetylcholine on the isolated pacemaker of the Rana temporaria heart. Bioelectrical activity of individual cells and sum total activity of the preparation were recorded. Exogenous acetylcholine was found not only to inhibit, but also to accelerate the rhythm of pacemaker cell... | 310,324 | [
-0.08414285,
0.1022225,
-0.5477199,
0.1220487,
-0.07790367,
-0.2577597,
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0.0629041,
-0.1051278,
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-0.04740329,
0.1973024,
0.2172103,
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-0.4128399,
0.1474743,
0.1889734,
0.1921432,
0.4910791,
0.1696851,
-0.0585936,
0.1... |
DNA-synthesizing T and non-T cells in chronic lymphocytic leukemia. | In 21 patients with chronic lymphocytic leukemia (CLL) and in 8 hematologically normal persons the number of DNA-synthesizing peripheral blood lymphocytes was investigated by autoradiographic techniques. The lymphocytes were differentiated by EN-rosette tests into T and non-T lymphoid cells. The results show a normal n... | 310,327 | [
-0.07920343,
-0.1005673,
-0.1594471,
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0.1303014,
-0.4688827,
0.0467969,
0.03873983,
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0.2242136,
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0.3052754,
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0.6023829,
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-0.06449504,
0.1611898,
-0.06122814,
0.3255714,
0.4621002,
0.1966043,
-0.2344799,
... |
Adult Haemophilus influenzae type B vertebral osteomyelitis: a case report and review of the literature. | Osteomyelitis in adults due to Haemophilus influenzae is exceedingly rare. We report a case of H. influenzae type b vertebral osteomyelitis in an adult. Review of the English literature reveals one other adult patient with H. influenzae osteomyelitis, and sporadic pediatric cases. Although a variety of predisposing hos... | 310,376 | [
-0.2624982,
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-0.1461746,
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0.0478598,
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0.2358596,
0.3084194,
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0.04525124,
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0.1026955,
-0.4191783,
0.0596673,
0.2139038,
-0.2205734,
-0.072745,
... |
Experience with a Fourier method for determining the extracellular potential fields of excitable cells with cylindrical geometry. | In this chapter, well-known solutions that utilize a Fourier transform method for determining the extracellular, volume-conductor potential distribution surrounding elongated excitable cells of cylindrical geometry are reformulated as a discrete Fourier transform (DFT) problem, which subsequently permits the volume-con... | 310,379 | [
0.190342,
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0.2231953,
0.1054702,
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0.1592942,
0.1197264,
0.08564214,
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0.1197783,
0.1205832,
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0.1621769,
-0.2677569,
0.02593791,
0.04689598,
0.2082939,
0.07307554,
0... |
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