title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Failure of medial forebrain bundle or raphe ablation to alter the daily temperature rhythm of the rat. | The data presented in the present study suggest that neither the ascending noradrenergic fibres confined to the MFB nor the serotonergic fibres originating in or passing through the mesencephalic raphe are essential for periodicity in body temperature. Both control and experimental groups, i.e., rats subjected to media... | 310,395 | [
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A histopathological study of lymphoid tissue reaction to metastatic nasopharyngeal carcinoma in nude mice. | In attempts to heterotransplant human NPc into nude mice, using seven cultured cell lines, we have succeeded in growing a carcinoma simplex, composed of Epstein-Barr virus-determined nuclear antigen-positive and Epstein-Barr virus genome-positive cancer cells, at the injected site with two of the cell lines. These orig... | 310,417 | [
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Interdependence of the two borders in a sodium transporting epithelium. Possible regulation by the transport pool. | Specific binding of 14C-amiloride to the mucosal surface of frog skin epithelium (Rana temporaria) has been used as a measure of the number of sodium entry sites. All binding measurements were made with the mucosal surface bathed in a solution containing 1.1 mM sodium. When manipulations were used which increased the i... | 310,468 | [
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[Results of Nandrolone therapy (Keratyl) in lesions and diseases of the cornea (author's transl)]. | The authors report on clinical experiences with the topical application of the synthetic hormone Nandrolon (Keratyl) in diseases of the cornea caused by exogenic, neurogenic, and combined exogenic-endogenic factors. In all cases a positive regenerative effect on epithelium and stroma of the cornea seemed to exist. The ... | 310,493 | [
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Clinical implications of preseptal (periorbital) cellulitis in childhood. | The available hospital records of all pediatric patients diagnosed as having periorbital, preseptal or orbital cellulitis over a five-year period were reviewed and compared to previously reported series. Only two of 39 patients had orbital cellulitis. The 37 patients with preseptal cellulitis had two characteristic cli... | 310,537 | [
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Evidence for RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factor. | Studies on the mechanism of action of nerve growth factor (NGF) were carried out with PC12 rat pheochromocytoma cells. PC12 cells are uniquely useful for such studies because they respond to, but (unlike normal neurons) do not require, NGF and may undergo either generation or regeneration of neurites in response to NGF... | 310,552 | [
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Biochemical characteristics of chronic lymphocytic leukaemia. Glucocorticoid receptors, B and T lymphocyte surface markers, concanavalin A-induced agglutination and thymidine incorporation. | Chronic lymphocytic leukaemia (CLL) has a variable clinical course and there is a great need of new prognostic laboratory parameters in this disease. 24 CLL patients were subjected to routine haematological and clinical investigation. The leukaemic cells were analyzed for surface immunoglobulins, complement and sheep r... | 310,576 | [
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[Concentration and composition of gangliosides in portions of the vertebrate brain]. | Studies have been made on gangliosides from various parts of the brain in 5 species of cartilaginous fishes, 2 species of teleosts, 2 amphibian species, 2 avian species and 3 species of mammals. Almost in all the species investigated, the highest content of gangliosides per weight unit of the brain were found in the fo... | 310,608 | [
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The effects of some variable factors on the T and B lymphocyte rosettes. | In this study the number of E rosettes increases with an incubation period at 4 degrees C up to 20 to 24 hours. Both EAC and especially E rosettes are shown to be sensitive to mechanical forces; vigorous shaking causes decrease of their number. | 310,646 | [
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Implications of heterophile antigens in immunological infertility in males. | Immunological study was conducted on serum and hydrocel fluids from males belonging to an equatorial African population heavily contaiminated by Filaria and Schistosoma. Anti-spermatozoa antibodies were detected by agglutination in 31 of 64 sera and 24 of 60 fluids, and by cytotoxicity in 19 of 64 sera and 8 of 60 flui... | 310,662 | [
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[Immune response and tolerance to S. typhi Vi-antigen in T-lymphocyte depleted mice]. | Comparison of immune response to Vi-antigen in thymetomized letally irradiated and reconstituted with fetal liver cells mice and in control animals revealed no difference between the two groups. The absence of enchancement of antibody formation in T cell depleted mice favours thymic-independent regulation of immune res... | 310,695 | [
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The effect of undernutrition on immunological responses to BCG and TAB vaccines in mice maintained on a natural diet. | A study was made on the effect of undernutrition on the immunological responses of mice to TAB and BCG vaccines. The mice were fed a diet comprising chapati and germinated grams; one group was fed ad libitum while another was given half the quantity consumed by the first group. The undernourished mice showed a poor imm... | 310,720 | [
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Relation of creatine kinase isoenzyme MB to postoperative electrocardiographic diagnosis in patients undergoing coronary-artery bypass surgery. | We compared (a) the frequency of detection of isoenzyme MB of creatine kinase (CK; EC 2.7.3.2) in serum of patients undergoing coronary-artery bypass surgery, (b) the interval during uhich its activity was supranormal in serum, and (c) an index of the amount of CK released into blood ("CK-MB area") with postoperative e... | 310,739 | [
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Long-term antiarrhythmic therapy with N-acetylprocainamide. | The effects of long-term NAPA therapy were evaluated in 6 patients with chronic PVCs known to respond to this drug during a previous placebo-controlled, dose-ranging trial. Underlying cardiac status was evaluated every six months by switching each patient from NAPA to placebo. Placebo period PVC frequency after one yea... | 310,748 | [
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Studies of hyperthymic mice. II. The influence of thymus grafts on cell flow through the peripheral T-cell pool. | In normal CBA/H mice implanted under the kidney capsule with eight CBA/H.T6T6 neonatal thymus lobes it was observed that the percentage of marked thymus-graft derived T cells in the periphery, after building up to a peak, showed a biphasic exponential decline. The initial decline was very rapid and appeared to be due t... | 310,804 | [
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A receptor for IgA on human T lymphocytes. | Receptors for IgA antibody-antigen complexes were demonstrated on 2 to 18% (mean 6.7%) of human peripheral blood T cells. The proportion of cells bearing detectable IgA receptors was low in freshly prepared T cells and increased in number after 18 to 24 hr of culture similar to the time course of appearance of the Tmu ... | 310,836 | [
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Suppressor activity of splenocytes from mice treated with Ecteinascidia turbinata extract. | Extracts of a marine tunicate, Ecteinascidia turbinata (Ete) were previously shown to be capable of suppressing humoral and cellular immune responses in vivo and in vitro. In the present work we have examined the mechanisms of suppression in Ete-treated DBA/2 and BALB/c mice. Treatment with Ete resulted in a significan... | 310,837 | [
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Purification and biochemical characterization of human lymphocyte mitogenic factor (LMF). | Supernatants of human T lymphocytes stimulated by TT antigen release two factors that induce mitogenesis in autologous and allogeneic B lymphocytes. These factors are precipitated by 60% ammonium sulfate and 50% ethanol, and are both destroyed by heating to 70 degrees C for 5 min. By equilibrium ultracentrifugation the... | 310,850 | [
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Contraction transients of skinned muscle fibers: effects of calcium and ionic strength. | Calcium and ionic strength are both known to modify the force developed by skinned frog muscle fibers. To determine how these parameters affect the cross-bridge contraction mechanism, the isotonic velocity transients following step changes in load were studied in solutions in which calcium concentration and ionic stren... | 310,868 | [
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Incorporating research in a service setting. | There are similarities between the research process and problem-solving-evaluation mechanisms already in use in nursing service. The author describes the utility of each process and the rationale for implementing research in the nursing service setting. The nursing auit is recommended as the intstitutional mechanism fo... | 310,872 | [
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The relationship of alpha1-antitrypsin to inflammatory periodontal disease. | Alpha1-antitrypsin (alpha1-AT) is a serum protease inhibitor with a well established role in bodily defense against destructive inflammatory diseases. alpha1-AT exhibits inheritable genetic polymorphism (Pi types). Certain Pi types have been shown to predispose to emphysema and, in this study, also appear to be related... | 310,876 | [
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Non linear volume flow dependence on osmotic pressure difference in frog skin. | The volume flow dependence upon the osmotic pressure difference of both impermeant (sucrose) and permeable (NaCl) species has been investigated in leg skin bags of Rana esculenta. It is concluded: 1. The hydration-dehydration error in the flow measurement with leg skin bags is negligible. 2. The flow-force relationship... | 310,878 | [
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Afferent and efferent components of the facial nerve in the bullfrog (Rana catesbeiana). | The afferent and efferent components of the facial nerve were traced within the brain stem of Rana catesbeiana, using three different neuroanatomical techniques. Primary afferent fibers could be traced to the spinal tract of trigeminal nerve and to fasciculus solitarius as far caudally as the first or second spinal seg... | 310,889 | [
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Haemophilus influenzae as a cause of Brodie's abscess in an infant. | Brodie's abscess is a form of subacute osteomyelitis which is defined by a particular constellation of clinical, radiological and pathological features. Its occurrence in infants is extremely rare. This case documents just such an occurrence. To our knowledge, the pathogen Haemophilus influenzae has not been previously... | 310,910 | [
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[Lymphocyte sub-populations and immunoglobulin concentrations in palatine and fancial tonsils (author's transl)]. | The number of B- and T-lymphocytes as well as the cytological composition and concentrations of IgG, IgM, and IgA are compared in children's palatine and fancial tonsils. The B-lymphocytes prevail in both organs. IgG is the main immunoglobulin and IgM and IgA follow in their concentrations. No significant differences b... | 310,938 | [
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Coronary artery surgery: indications and recent experience. | The comprehensive experience of coronary artery surgery in a Cardiothoracic Unit over a 31-month period is reviewed. Hospital mortality for elective bypass grafting was 3.9% overall and 2.5% in those with good pre-operative left ventricular function. Major influences on hospital mortality were pre-operative left ventri... | 310,999 | [
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Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells. | Deoxyadenosine at low concentrations and in the presence of an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is markedly toxic to lymphoblast cell lines of T cell origin but does not impair growth of B cell lines. Deoxyguanosine is also more toxic for T lymphoblasts. In the presence of deoxyad... | 311,004 | [
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[Diagnostic criteria of periodontal diseases]. | The designation of a periodontal disease and its classification do not permit to draw conclusions as to its targeted therapy. Since the parameters needed for the diagnosis of periodontal diseases are very numerous, they should be reduced by a problem-oriented diagnosis which corresponds to the aims and objectives (trea... | 311,094 | [
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0.1816998,
0.02179724,
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-0.1344507,
-0.3674894,
-0.0910464,
-0.04686862,
-0.7600629,
-0.1759074,
-0.3227856,
0.1923973,
-0.1481154,
0.2220913,
0.139892,
0.0470471,
-0.1473764,
... |
T and B cell populations in platelet donors. | T and B lymphocyte populations were monitored in the peripheral blood of two long-term plateletpheresis donors. The studies showed minimal fluctuation of both populations compared to the normal controls. The evidence so far accumulated seems to indicate that long-term manual plateletpheresis has no appreciable effect o... | 311,097 | [
-0.2114192,
0.09480969,
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... |
Splenic vein obstruction with bleeding gastric varices: a diagnostic approach. | It is important to separate splenic vein obstruction from other causes of variceal bleeding. The authors provide a diagnostic sequence for avoiding errors of management, citing a case to illustrate. | 311,111 | [
-0.157698,
0.183184,
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0.04639274,
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-0.01953971,
-0.1712... |
Cell surface markers in chronic lymphotic leukaemia. | Surface markers were applied for the study of the peripheral lymphocyte population in chronic lymphotic leukaemia. The proportion of B-lymphocytes recognized by EAC-rosetting and by surface-bound Ig was found higher in chronic lymphotic leukaemia than in normal controls. On the other hand, the E-rosette test revealed a... | 311,131 | [
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0.2163932,
0.163457,
0.2201236,
0.004692801,
-0.... |
The anti-inflammatory profile of dapsone in animal models of inflammation. | Dapsone has been shown to possess anti-inflammatory activity in a variety of animal models. It possesses oral anti-oedema activity especially pronounced in novel models of acute inflammation, viz. anti-IgG and reversed passive Arthus oedemas. However, it is not very active in the guinea pig u.v. erythema model. It is e... | 311,146 | [
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0.1748459,
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... |
Pelvic lipomatosis: diagnosis by computerized tomography scan. | Pelvic lipomatosis is a rare, relatively self-limiting disease characterized by the overgrowth of unencapsulated lipomatous tissue within the pelvis. The diagnosis is suggested, but not substantiated, by the striking roentgenographic changes noted on barium enema and intravenous pyelogram. Previously, pelvic laparotomy... | 311,155 | [
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0.2766317,
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0.2700082,
0.2286925,
-0.1317181... |
Chloramphenicol and phenobarbitone--a drug interaction. | Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial... | 311,186 | [
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0.1839389,
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Recent trends in the immunology of contact sensitivity. I. | The article reviews the recent experimental data that influenced the present concept of contact sensitivity. Particular emphasis is on the mechanism of stimulation of antigen-inexperienced specific lymphocytes, the eliciting phase, and the role of suppressor cells in sensitization and tolerance. | 311,269 | [
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... |
[Coronary collaterals and function of the left ventricle. Practical applications of a collateral score]. | The most important collateral pathways in the coronary artery system goes through the apex, the ventricular septum, left and right atrial branches and the ventricular wall of the left ventricle. In a collective of 52 patients who underwent aortocoronary-bypass surgery we controlled the collateral circulation and left v... | 311,312 | [
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Sera from volunteers immunized by planned blood transfusions as source of DR cytotoxic typing reagents. | Sera from volunteers immunized with planned blood transfusions were tested for anti DR cytotoxic antibodies with a panel of HLA typed cultured human lymphoid cells using a variety of serological techniques. The majority of sera contained DR cytotoxic antibodies. The specificity of DR antibodies in seven sera was determ... | 311,335 | [
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0.10... |
Sensitization of guinea pigs to levamisole. | Levamisole, an anti-helminthic drug used also as an immunostimulating agent, has been found to be a potent skin sensitizer in experimental animal models. Sensitization is associated with marked T-lymphocyte proliferation in the draining lymph node. It is suggested that immunostimulation through increase in the T-lympho... | 311,351 | [
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0.4038697,
0.0426439,
0.1429031,
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Intraocular levels of cefamandole compared with cefazolin after subconjunctival injection in rabbits. | We compared the intraocular pharmacokinetics of cefazolin with those of cefamandole, a recently marketed cephalosporin with enhanced activity against gram-negative bacilli. Following subconjunctival injection of 12.5 mg into infected eyes (S. aureus endophthalmitis) of pigmented rabbits, both drugs reached peak concent... | 311,356 | [
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0.3589649,
... |
Force-velocity relation in normal and nitrate-treated frog single muscle fibres during rise of tension in an isometric tetanus. | 1. The force-velocity (P-V) relation for normal or NO-3 treated single fibres isolated from the semitendinosus muscle of the frog was determined at given times during the rise of tension and the plateau of isometric tetani. Experiments were made at about 2.25 micron sarcomere length and at constant temperatures, from 3... | 311,382 | [
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A new nonsteroidal analgesic-antiinflammatory agent. Synthesis and activity of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and related compounds. | In order to examine analgesic and antinflammatory activities, various 2-alkyl- or 2-alkenyl-4-alkoxy-5-(substituted amino)-3(2H)-pyridazinones were prepared. Among the compounds prepared, 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (8) was evaluated to be the most attractive compound as an analgesic-antiinflammat... | 311,385 | [
-0.2528886,
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Lymphocyte function in the blood of patients with untreated non-Hodgkin lymphoma: influence of stage and pathology. | Lymphocytotoxicity of T, non-T and K cells was found to be diminished in a proportion of 30 patients with untreated non-Hodgkin lymphoma; T cell number as enumerated by E sheep cell rosettes was also reduced. The reduction was greatest in patients with disease of unfavorable pathology; the effect of stage on these test... | 311,411 | [
-0.009576744,
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0.2966359,
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0.1430212,
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... |
Flunarizine and cinnarizine as vestibular depressants. A statistical study. | The authors analysed the vestibular depressant activity of flunarizine and cinnarizine, as compared to a placebo, in 58 patients with peripheral labyrinthine disorders. The activity of the medications was judged by the reduction of the average velocity of the slow phase of the post-caloric nystagmus, before and after t... | 311,458 | [
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0.1197281,
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0.2076889,
-0.02780... |
Induction of amplified synthesis and secretion of IgM by fusion of murine 'b lymphoma with myeloma cells. | Murine B lymphoma cultured cell lines bearing membrane IgM and lacking the ability to secrete measurable amounts of IgM were fused with drug-resistant cell lines derived from the IgG2b-producing MPC-11 myeloma. Many of the hybrid clones synthesized and secreted large amounts of IgM, as judged by radial and double immun... | 311,476 | [
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-... |
[Immune profile in patients with Hodgkin's disease in long-term remission after cytostatic chemotherapy]. | 13 patients in complete and prolonged remission after treatment with cytostatic chemotherapy for disseminated Hodgkin's disease have been investigated for immune competence by a total of 27 immunological parameters. 11 patients had abnormal values for lymphocyte populations, lymphocyte function and skin tests. The immu... | 311,514 | [
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Aplastic anemia associated with bone marrow suppressor T-cell hyperactivity: successful treatment with antithymocyte globulin. | In five patients with idiopathic aplastic anemia, the colony-forming unit (CFU-c) assay was used to quantitate stem cells and test the possible presence of suppressor cells inhibiting bone marrow differentiation. All five marrows failed to form CFU-c. In one out of the five cases tested, coculture of the patient's marr... | 311,583 | [
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0.3645347,
0.2219204,
0.009352664,
0.15443... |
Immunoglobulin E in human aqueous humor and corresponding serum. A physiopathological and clinical study. | The analysis of IgE in aqueous humor yielded an average concentration of 3.4 +/- 0.97 U/ml for 22 cataract patients and 5.5 +/- 3.42 U/ml for five uveitis patients. The IgE level in aqueous humor (IgEa.h.) of the cases examined is most probably, beside hematoocular diffusion of serum IgEs, the result of intra-ocular Ig... | 311,597 | [
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0.2531837,
-0.271160... |
Plasmid-mediated ampicillin resistance in Haemophilus ducreyi. | Three of 19 strains of Haemophilus ducreyi, isolated during a recent outbreak of chancroid, were found to produce beta-lactamase and to harbor a 6.0 x 10(6)-dalton plasmid. Escherichia coli transformed with this plasmid acquired beta-lactamase-mediated resistance to ampicillin. The guanine-plus-cytosine content of the ... | 311,618 | [
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0.7526385,
-0.1260463,
-0.1584298,... |
Cell-mediated immunity in vitro in atopic dermatitis. | The function of T cells in atopic dermatitis was studied by leukocyte migration agarose and lymphocyte transformation tests. We found that phytohemagglutinin (PHA)- and PPD-induced release of leukocyte migration inhibition factor (LIF) from lymphocytes is significantly decreased (P less than .001) in patients with ato... | 311,620 | [
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0.2093375,
0.1484443,
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-0.2160725,
... |
Symposium on membrane markers and antigens of human lymphocytes and leukemic cells. | B lymphocytes, mediators of humoral immunity, carry easily detectable SIg, form rosettes with RBC coated with IgM and complement (EAC rosetting) and bind aggregated Ig (Fc receptor activity). Human T lymphocytes, mediators of cellular immunity, lack a specific antigen found on mice T lymphocytes (theta antigens). They ... | 311,633 | [
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0.04463985,
-0.05009885,
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0.2860846,
0.2123135,
0.2433447,
-0.1479887,
... |
A chemical-modification approach to the olfactory code. Studies with a thiol-specific reagent. | The effects of thiol-specific reagents on the amplitude of the electro-olfactogram (E.O.G.) responses elicited from frog olfactory mucosa by pulses of odorant vapours was studied. The impermeant thiol-specific reagent mersalyl [(3-{[2-(carboxymethoxy)-benzoyl]amino}-2-methoxypropyl)hydroxymercury monosodium salt] bring... | 311,638 | [
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0.0974507,
0.2647476,
0.216842,
0.2164799,
0.1419089,
-0.... |
Idiopathic edema as a cause of nonarticular rheumatism. | Six women, aged 24 to 53, presented with symptoms of diffuse aching, morning stiffness, and fatigue, but demonstrated no objective abnormalities on joint examination or in laboratory studies. Each was found to have idiopathic edema, a disorder of fluid retention probably related to an abnormality of capillary permeabil... | 311,641 | [
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0.02982622,
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-0.07732537,
-0.07108548,
-0.05501845,
-0.007... |
Arterial counterpulsation in severe refractory heart failure complicating acute myocardial infarction. | The role of arterial counterpulsation was sought in 100 patients with severe refractory cardiac failure complicating myocardial infarction. Seventy-four were in shock and 26 were not. Average duration of counterpulsation was 7.0 days. Hospital survival was 34 per cent (25/74) in shock (predicted less than 10%) and 65 p... | 311,648 | [
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0.2109345,
0.1618562,
0.006865168,
0.2440297,
0.4593287,
-0.08101726,
-0.15641... |
Erythroid leukemia induced by Friend lymphatic leukemia virus in T-cell-depleted mice. | BALB/c mice depleted of T-cells by thymectomy at 3 to 5 days of age and by treatment with antithymocyte serum were inoculated with the lymphatic leukemia virus derived from Friend virus. After a long latent period, these animals developed erythroid leukemia. In contrast, intact control mice inoculated with Friend virus... | 311,686 | [
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0.3721254,
0.3029074,
0.1983305,
-0.1265638,
... |
Abnormal blood vessels in the gastric antrum: a cause of upper-gastrointestinal bleeding. | Three patients who bled from curious vascular lesions of the gastric antrum are described. Each presented with an iron-deficiency anemia. Histological examination in two of the patients demonstrated numerous ectatic submucosal vessels in the antrum, the appearances being somewhat similar to angiodysplasia of the colon.... | 311,727 | [
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0.4858638,
0.1375193,
-0.0302252,
... |
Serum prolactin and estrogen pattern in human gestation. | In a group of 17 normal women serum levels of fetoplacental hormones (estradiol, progesterone and human placental lactogen) and of prolactin were measured serially from the 6th week to the end of pregnancy. The levels of these hormones increased gradually until the term. On the basis of these observations it may be con... | 311,730 | [
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0.3698482,
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Changes of LH, TSH, GH, FSH and PRL in pituitaries and sera of rats after thyroidectomy and thyroxine treatment as studied by radioimmunoassay and disc electrophoresis. | Rat pituitary hormones (LH, TSH, GH, FSH and PRL) were located in polyacrylamide gels after the separation of rat pituitary homogenate with the aid of electrophoresis. Furthermore, the incorporation of 3H-glucosamine and 14C-leucine into various protein fractions of incubation media and pituitaries incubated for 6 h in... | 311,732 | [
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0.2462678,
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... |
The proliferative states of density subpopulations of granulocyte-macrophage progenitor cells. | Possible variation in proliferative state among subpopulations of myelopoietic progenitor cells of mouse bone marrow (CFU-c), which form in vitro colonies of granulocytes and/or macrophages, was investigated by estimation of the percentage in S phase of the cell cycle. Subpopulations of CFU-c, obtained by separation of... | 311,738 | [
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0.8459137,
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0.03370547... |
Stimulation of alkaline secretion in amphibian-isolated gastric mucosa by 16,16-dimethyl PGE2 and PGF2 alpha. A proposed explanation for some of the cytoprotective actions of prostaglandins. | The mechanism of the gastric cytoprotective action of prostaglandins is unknown but seems to be unrelated to inhibition of acid secretion. In the present study, effects of the prostaglandins, 16,16-dimethyl E2 and F2 alpha on H+ and HCO-3 secretion and electrical properties in amphibian-isolated gastric mucosa were stu... | 311,742 | [
-0.2027341,
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0.1924083,
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... |
Heat-induced thermal resistance and its relationship to lysosomal response. | Two separate effects of hyperthermia on mouse splenic lysosomes have been reported, dependent on the severity of the treatment. Heating to temperatures below 42.5 degrees C causes a transient increase in lysosomal acid phosphatase activity which can be correlated with the ability of moderate hyperthermia to potentiate ... | 311,759 | [
-0.06030083,
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0.473976,
0.3734304,
0.006683565,
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... |
Studies on suppressor cell function in thyroid diseases. | Suppressor cell function of peripheral mononuclear cells has been examined in patients with Graves' disease, Hashimoto's thyroiditis, and thyroid cancer, as well as in healthy subjects. Suppressor cell function was assessed through two methods: 1) measurement of enhanced blastogenesis after 24-h preculture and 2) conca... | 311,776 | [
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0.375413,
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0.271754,
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Decreased circulating thymus-derived cells with receptors for the Fc portion of immunoglobulin G in systemic lupus erythematosus. | Thymus-derived cells with receptors for the Fc portion of immunoglobulin G (Fcgamma+ T cells) have recently been found to have a suppressor function, a function that is decreased in systemic lupus erythematosus (SLE). Fcgamma+ T cells were found significantly diminished in 21 untreated SLE patients, particularly in the... | 311,785 | [
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A method of correcting for linear drift in computed tomography brain scans. | Linear drift of X-ray attenuation coefficients must be corrected if quantitative comparisons are to be made between computed tomography (CT) brain scans of the same individual performed at different times. Such a correction is accomplished by comparing the low (cerebrospinal fluid) end of the attenuation coefficient fr... | 311,794 | [
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0.0577523,
-... |
Studies on the mechanism of ristocetin-induced platelet agglutination: binding of ristocetin to platelets. | Ristocetin was trace-labeled with [3H] by the reductive methylation method. It was shown to agglutinate human platelets in the presence of VIIIR:WF in a manner indistinguishable from unlabeled ristocetin. The binding of the labeled ristocetin to normal and enzyme-modified human platelets was studied both in the presenc... | 311,800 | [
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0.1671957,
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A simple radiometric assay for methotrexate and other folate antagonists. | A rapid radiometric assay for the folate antagonist MTX, based on the inhibition of chicken liver dihydrofolate reductase activity, has been developed. In the system the inhibition by MTX of the reduction of tritiated FH2 is standardized and used to quantitate this antagonist in plasma of subjects receiving high-dose M... | 311,801 | [
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0.4548165,
0.006224975,
0.1418898,
0.1203147,
0... |
Specificity of cytotoxicity T cells directed to influenza virus hemagglutinin. | Purified type A influenza viral hemagglutinin stimulates an in vitro cell-mediated cytotoxic cell response that exhibits a high degree of specificity for the immunizing hemagglutinin. The response magnitude is proportional to the hemagglutinin dose used for stimulation. The lytic activity of the effector cells is H-2 r... | 311,817 | [
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0.176499,
0.5123807,
0.1302005,
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Dark-adaptation in frog rods: changes in the stimulus-response function. | 1. Aspartate-isolated photoresponses of the frog's rods to weak and strong flashes have been recorded during dark-adaptation after bleaching a fraction of rhodopsin (generally 4--30%). Stimulus--response functions were measured before the bleach and in the steady state after dark-adaptation. 2. The movements of the ope... | 311,826 | [
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0.3676652,
0.288803,
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... |
Vestibulo-ocular function during co-ordinated head and eye movements to acquire visual targets. | 1. Experiments have been conducted on human subjects in an attempt to establish the role of the vestibulo-ocular reflex in the co-ordination of head and eye movements during visual target acquisition. 2. When the subject moved head and eyes to acquire visual targets in the horizontal plane, the eye movement consisted o... | 311,828 | [
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0.1619947,
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Cellular immunity in patients with epidermoid cancer of the head and neck. | Forty-three patients with squamous cell carcinoma of the head and neck were evaluated immunologically at various times before and after treatment. Impaired DNCB skin reactivity was found in patients with more advanced disease (Stages II-IV). In the 24 patients evaluated prior to therapy, only the mean percentages of tw... | 311,881 | [
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Predefinitive and postdefinitive chemotherapy for locally advanced squamous carcinoma of the head and neck. | Advanced squamous carcinoma of the head and neck remains refractory to the best combinations of surgery and radiotherapy. Weekly methotrexate in high doses with leucovorin "rescue" is able to produce significant remissions in a majority of patients treated palliatively for recurrent disease yet is associated with littl... | 311,882 | [
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0.108519,
0.02156683,
... |
Paracortical activity in the lymph nodes draining female breast carcinoma. | Three hundred and two female breast carcinomas were assessed histologically with special attention focused on the nuclear grade of the tumor, the stromal lymphocyte reaction and the morphology of the paracortical areas of the regional lymph nodes. These morphologic parameters were correlated with the 5-year survival da... | 311,901 | [
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0.25181,
0.1003425,
... |
[Immune structure of the population of Moscow to the strains of the influenza viruses A(H3N2), A(H1N1) and B circulating in 1977]. | Examinations for the presence of antihemagglutinins to influenza A(H3N2), A(H1N1) and B virus strains in the sera from people of different ages collected in April-May and October-November, 1977, showed that influenza A(H1N1) virus began to circulate in the human population of Moscow before the onset of an overt epidemi... | 311,977 | [
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0.1219597,
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Cathepsin B and collagenolytic cathepsin in the aqueous humor of patients with Behçet's disease. | Cathepsin B and collagenolytic cathepsin activities were studied biochemically in human aqueous humor. The enzyme activities were found to be significantly high in the aqueous humor of the patients with Behçet's disease, but not detectable in those with senile cataract, retinoblastoma, and maxillar carcinoma. These dat... | 312,033 | [
-0.09277864,
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0.1267817,
0.5902073,
0.09940024,
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0.126777... |
Rheumatoid meningitis: a localized immune process. | Rheumatoid pachymeningitis is a rare complication of rheumatoid arthritis. This disease was confined to the dura and pia-arachnoid of the lumbar cord in our patient. Her neurologic deficits responded to surgical decompression and corticosteroid therapy. Radiologic evidence and the differences in cell count, protein, an... | 312,046 | [
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0.05641... |
Studies on the influence of thiols on lymphocytes (T-type lymphocytes) functions. | We described changes in nonprotein sulfhydryl content and in intracellular concentration of cysteine (unbound form) in lymphocytes incubated with cysteine, cysteine hydrazide and D-penicillamine (dimethy lcysteine) in concentrations which do not alter the viability of the cells. Essential differences between the action... | 312,073 | [
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0.4466968,
0.07463343,
0.2973874,
0.1557647,
-... |
Investigations on immunological and pharmacological activities of thymus factor X/TFX. | Immunological activity of TFX was investigated on mice employing the imuran (rosette) and hydrocortisone (cytotoxic) tests. Pharmacological activity in the acute and chronic experiments was also evaluated. | 312,078 | [
-0.1793472,
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... |
Colony stimulating factor (CSF) activity in human and murine sera. | Substances with CSF activity were studied in human and murine sera. Gel filtration of the sera on Sephadex G-200 showed that fractions with molecular weight of 14,000 and 6000 D were active in the CSF test. When mice were stimulated with endotoxin, CSF activity of both fractions was twice as high as in control animals,... | 312,079 | [
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0.4588568,
-0.001720704,
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... |
Experimental allergic encephalomyelitis in chickens. | Experimental allergic encephalomyelitis (EAE) in chickens of the inbred lines IC, CB, WB and (CBxIC)F1 hybrids was investigated. The IC line and (CBxIC)F1 hybrids gave the best reactions. In bursectomized chickens only slight changes in brain were observed. The intensity of EAE in thymectomized chickens was highly supp... | 312,083 | [
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0.02505909,
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0.3242435,
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0.09021404,
0.06740997,
... |
Diagnostic specificity of autoantibodies. II. Clustering of autoantibodies--role in diagnosis and in comparison to E--and EAC-RFC peripheral blood profiles and immunoglobulin levels. | Clustering of ANA and SMA was evaluated in patients with various internal diseases as a pattern of autoantibody formation. SMA was found in ANA positive patients with chronic hepatitis, undefined collagenoses and autoallergic thyroid diseases significantly more frequently, than in patients without any autoallergic diso... | 312,092 | [
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0.1358855,
0.2847038,
-0.09706891,
-0.1672938,
... |
Immunological dysfunctions in multiple sclerosis. I. Diminution of 'active' thymus-derived lymphocytes and presence of immunomodulating serum factors. | The peripheral blood of twenty-eight patients with multiple sclerosis (MS) was examined for 'active' thymus (TA) derived lymphocytes (PBL) and the presence of serum factors which impair the lymphocyte blastogenic response and the migration of leucocytes from capillary tubes. MS patients exhibited a significant reductio... | 312,171 | [
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0.2425963,
0.2056246,
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0.1678673,
0... |
Specific binding of T lymphocytes to macrophages IV. Dependence on cations, temperature and cytochalasin B-sensitive mechanisms. | Peritoneal exudate lymphocytes (PEL) from immune guinea pigs adhere to macrophages carrying the relevant antigen and are thereby stimulated to proliferate in culture. The resultant PEL represent a population highly enriched with regard to their capacity to specifically rebind to antigen-pulsed macrophages. We have stud... | 312,205 | [
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0.4032965,
0.1544352,
0.4706939,
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... |
A suppressor cell in the response of rabbit T cells to Con A. | The response to Concanavalin A is regulated by a helper cell, described elsewhere (4), and by a suppressor cell, described in this paper. This suppressor cell is an adherent T cell with Fc receptors. Evidence for properties of the suppressor cell was obtained by two types of experiments: 1) regulatory cells gave more h... | 312,248 | [
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0.3295891,
0.1758721,
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... |
The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin. | A soluble factor(s), human T-lymphocyte derived help factor (HHF), generated following pokeweed mitogen (PWM) activation of irradiated human peripheral blood T lymphocytes was shown to substitute partially for T-lymphocyte helper activity in the T-lymphocyte dependent PWM-stimulated synthesis of immunoglobulin by B cel... | 312,259 | [
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0.2893861,
0.01308065,
0.2626314,
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0.2790669,
0.01954823,
-0.2865771,
-0.07730002,
-0.1993355,
-0.03161531,
-0.3661944,
-0.1607851,
0.4274907,
0.3182198,
0.2945375,
-0.1632765,
... |
Failure to block lymphocyte Fc receptor with anti-B lymphocyte sera (anti-DRW) in man. | Sera harvested from multiparous women or from allograft recipients who had rejected their kidneys and containing various anti-DRW specificities, were studied on peripheral blood or lymph-node lymphocytes bearing or lacking the relevant B-cell alloantigen, for their EA or EAC-rosette-inhibition activity. Inhibition of C... | 312,261 | [
0.2842991,
0.1098263,
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0.2366819,
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0.4268586,
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Brain edema defined by cranial computed tomography. | Cranial computed tomography permitted an in vivo classification of brain edema. The distinction of the four basic types of edema (vasogenic, ischemic, cytotoxic, and periventricular) was important in establishing the chronicity, extent, and pathologic basis of cerebral abnormalities. Vasogenic edema (neoplasm, abscess)... | 312,299 | [
-0.2925648,
0.4165604,
0.07468756,
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0.02169685,
0... |
Intracranial neurosarcoidosis. | Neuroradiological findings in two cases of histologically confirmed intracranial sarcoidosis are presented, one with periaqueductal granulomata causing aqueduct obstruction. The granulomatous aggregation was of slightly greater attenuation than normal brain parenchyma and did enhance homogeneously following contrast me... | 312,300 | [
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0.2845488,
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0.02036138,
0.1674365,
0.0968397,... |
Purification of rabbit B spleen cells by removal of adherent and of T cells. | B lymphocytes from the rabbit spleen were freed of T cells by removal of cells which formed rosettes with papain-treated rabbit erythrocytes. Additional purification could be achieved if fractionation by rosette removal was preceded by removal with a magnet of cells which adhered to or ingested poly L-lysine coated iro... | 312,302 | [
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0.2793827,
0.4561986,
0.2662017,
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-0.206... |
Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease. | Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (IgG) and their monovalent (Fab fragmen... | 312,307 | [
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0.2061015,
0.4462161,
0.04663413,
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0.... |
Extracellular potassium accumulation in voltage-clamped frog ventricular muscle. | 1. Application of voltage clamp pulses (1--10 sec) to frog ventricular strips causes temporary changes in the extracellular K concentration. 2. The changes in the extracellular K concentration can be estimated from (a) slowly decaying post-clamp after-potentials, (b) changes in the action potential duration, and (c) me... | 312,322 | [
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0.02946038,
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0.2778146,
0.238041,
-0.0569279,
0.5295764,
0.1352443,
0.2484533,
0.1524... |
Increased prevalence of mature females bearing pigmented oocytes from populations of Minnesota Rana pipiens. | Mature female leopard frogs, Rana pipiens, collected from several sites in Minnesota from 1967 through 1977, were examined for the presence of pigmented oocytes. An increase in the percent of mature females with pigmented oocytes was observed in the frogs captured in 1977 compared to those captured earlier. Coincident ... | 312,362 | [
0.2466905,
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0.08679997,
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0.1653464,
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0.288117,
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0.239935,
0.1922696,
-0.2728574,
-0.... |
Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine. | In order to clarify the role of indoleamine 2,3-dioxygenase [indole:oxygen 2,3-oxidoreductase (decyclizing), EC 1.13.11.17] in the metabolism of serotonin, DL-5-hydroxy[methylene-(14)C]tryptophan, a precursor of serotonin, was incubated with slices of rabbit ileum. Resulting metabolites were separated by DEAE-cellulose... | 312,499 | [
-0.04694584,
-0.115592,
0.0822444,
-0.04592057,
0.2443234,
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0.1890019,
0.07515702,
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0.3615348,
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0.07959233,
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0.23363,
0.4568119,
-0.0179654,
0.141376,
0.7570195,
-0.2444376,
0.0... |
Decreased hybrid susceptibility to murine myeloma grafts. | The behavior of BALB/c myeloma transplants in (C57BL/10 X BALB/c)F1 hybrids was investigated. The F1 hybrids were less susceptible to the grafts than were the parental BALB/c hosts. Host susceptibility was X-ray and cyclophosphamide sensitive, but an immune hypothesis was not favored since no memory was demonstrable. M... | 312,555 | [
0.08795356,
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0.1296528,
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0.02863044,
0.03852022,
0.09184474,
0.4100343,
-0.08849902,
-0.02945594,
... |
Endophthalmitis associated with Haemophilus influenzae type b bacteremia and meningitis. | The unusual occurrence of endophthalmitis associated with Haemophilus influenzae type b bacteremia and meningitis was confirmed in three young children during a five-year period. In contrast to bacterial endophthalmitis attributed to other microorganisms, these three infections resolved completely within a few days wit... | 312,601 | [
-0.2413319,
-0.05597124,
-0.1855437,
-0.06192347,
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-0.02390987,
0.4761501,
-0.1170882,
-0.02020679,
0.214606,
0.2440847,
0.108219... |
Plasma lipid distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. The Lipid Research Clinics Program Epidemiology Committee. | Cross-sectional age- and sex-specific plasma lipid distributions (means, medians and selected percentiles) are given for 48,431 white participants in visit 1 of the Lipid Research Clinics (LRC) Prevalence Study. This study consisted of two visits in which 10 LRCs screened participants selected from well-defined North A... | 312,704 | [
0.07024132,
0.03474081,
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-0.3895274,
-0.0002131425,
-0.2461004,
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0.4464131,
0.127646,
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0.09520978,
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0.07126864,
0.07776507,
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0.1302483,
0.0537021,
0.2101126,
0.2701351,
-0.00656537,
0.4473335,
-0.1624341,
... |
Rate-pressure product and myocardial oxygen consumption during surgery for coronary artery bypass. | Rate-pressure product (RPP) is a sensitive index of myocardial oxygen consumption (mVO2) in awake people. We wished to determine whether this relationship persisted under anesthesia and in the face of concurrent large changes in myocardial contractility and left ventricular filling pressures. In 16 patients scheduled f... | 312,708 | [
0.07337506,
-0.1574561,
-0.6011456,
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0.1103863,
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0.1028245,
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0.2085245,
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0.05851255,
0.3135294,
0.1484199,
0.1155172,
-0.1526436,
-0.05622443,... |
Gastrointestinal angiodysplasia associated with aortic valve disease: part of a spectrum of angiodysplasia of the gut. | Twelve patients with angiodysplasia of the gastrointestinal tract were seen at The Mary Imogene Bassett Hospital are presented. Six share the features of gastric or duodenal angiodysplasia, advanced age, and aortic valve disease. Of these 6 patients, 4 who bled repeatedly were treated with endoscopic coagulation of are... | 312,746 | [
-0.3480437,
-0.07311172,
-0.1942923,
-0.2593236,
0.3444442,
-0.2803435,
-0.08416599,
-0.07238107,
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0.3388295,
0.2943379,
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0.09366219,
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0.2000384,
-0.7383007,
0.1138028,
0.2701142,
-0.1073914,
0.5039896,
0.2594644,
-0.03755551... |
The effect of ionizing radiation on the fatty acid composition of natural fats and on lipid peroxide formation. | The effects of irradiation doses of 200-1000 krad on the fatty acid compositions of saturated and unsaturated natural food fats have been studied. Lard, coconut oil, corn oil, methyl linoleate and herring oil have been analysed before and after irradiation for lipid peroxide content and fatty acid composition. The effe... | 312,790 | [
0.03303912,
0.3420587,
0.01271563,
0.06357336,
0.3684939,
0.02932293,
-0.08528493,
0.0652904,
0.1653963,
0.3910108,
0.4067808,
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0.0120027,
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0.02192659,
0.3472308,
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0.633966,
0.30352,
0.7514092,
0.00896453,
0.02... |
Modification by timolol of catecholamine stimulation of chloride transport in isolated corneas. | In the isolated frog cornea, 10(-5)M timolol completely blocked the stimulation of chloride transport by 10(-6)M isoproterenol. In this preraration, timolol inconsistently modified the response to epinephrine. In some experiments, epinephrine added to the bathing medium after timolol caused a smaller than normal increa... | 312,796 | [
-0.103383,
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0.04099412,
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0.09898894,
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0.1606096,
0.03667876,
0.01628277,
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0.09865016,
0.006986543,
0.08722168,
0.2389113,... |
Similar molecular properties of granulocyte-macrophage colony-stimulating factors produced by different mouse organs in vitro and in vivo. | Granulocyte-macrophage colony-stimulating factor (GM-CSF) was partially purified from post-endotoxin serum and conditioned media produced by organs from both normal and endotoxin-injected C57BL mice. The organs used to condition medium were heart, thigh muscle, salivary gland, thymus, spleen, kidney, brain, and femur s... | 312,799 | [
-0.04884144,
0.03553307,
-0.1927135,
-0.04646519,
0.3529979,
-0.223667,
-0.02696726,
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0.07871173,
0.1685364,
0.09854101,
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0.3576118,
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0.2846493,
0.1025943,
0.121398,
-0.0194319... |
A physicochemical and immunologic comparison of the cell growth inhibitory activity of human lymphotoxins and interferons in vitro. | The physicochemical, immunologic, and biologic relationships between humam lymphotoxins (LT) and interferons (IF) present in supernatant fluids from lectin-stimulated peripheral blood lymphocytes (PBL) and a continuous B-lymphoblastoid cell line (PGLC-33h) were analyzed. LT activity obtained from lectin-activated PBL c... | 312,850 | [
-0.1349645,
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0.2867911,
0.03562461,
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0.4010225,
0.198484,
0.233891,
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0.1487043,
0.02712276,
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0.1492286,
0.111589,
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-0.3028695,
0.2504527,
0.5843546,
0.5798283,
0.1102506,
-0.3366092,
0.22012... |
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