title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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HLA antigen frequencies in flax byssinosis patients. | Not all workers exposed to flax dust contract byssinosis. It is not known what determines susceptibility or insusceptibility. This study is an attempt to establish whether the incidence of histocompatibility antigens is involved in susceptibility to the disease. Forty patients suffering from flax byssinosis were tissue... | 465,375 | [
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Red cell mass during and after normal pregnancy. | Red cell mass, derived from plasma volume and haematocrit, was calculated serially in 45 healthy women during pregnancy and 4 to 6 months after delivery. Compared to the non-pregnant, postpartum value there was a reduction of approximately 100 ml at 12 weeks gestation. An increase in red cell mass occurred thereafter: ... | 465,384 | [
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Malignant change in benign cystic teratoma of the ovary. | In a clinico-pathological study of malignant disease of the ovary in the former North East Metropolitan Region, malignant transformation of benign cystic teratoma has emerged as the commonest malignancy of "germ cell" origin. The clinical and pathological details of 12 patients are reported. | 465,388 | [
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Mechanisms in ocular hypertension. | This paper investigates the hypothesis that intermittent partial angle closure is one of the causes of ocular hypertension. 139 eyes from 76 patients with ocular hypertension were provoked with pilocarpine and phenylephrine. Four distinct responses appeared. Firstly, in 39 eyes (from 24 patients, 32%) gonioscopic closu... | 465,407 | [
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Changes in refraction between the ages of 1 and 3 1/2 years. | A study has been made of the changes in refraction as a sample of 148 children grew between the ages of 1 and 3 1/2 years. There was no decrease in hypermetropia, but there was a significant decrease in the incidence of astigmatism. Study of the changes in the refraction in the horizontal and vertical meridia of indivi... | 465,408 | [
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Survey of ophthalmic conditions in a Labrador community. I. Refractive errors. | Of the 745 available members of the population of Nain in Labrador 650 (87%) were screened for refractive errors and ocular disease. Refraction by retinoscopy was done in 553 and axial length measured by an optical method in 514. The results showed that the incidence of low degrees of myopia was higher in Inuit (Eskimo... | 465,417 | [
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A preliminary simulated iron fortification trial in South Indian preschool children. | 1. The effect of fortification of food with iron to provide 10 mg elemental Fe/child per d was studied in preschool children maintained on a cereal diet, over a 5-month period. 2. The absorption of 5 mg Fe as ferrous sulphate mixed in one meal was 3.3% of the test dose and when 3.3 mg was given with each of three meals... | 465,432 | [
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Relationship between biochemical and clinical indices of B-vitamin deficiency. A study in rural school boys. | 1. A study amongst schoolboys in villages around Hyderabad, India, showed that almost all the boys had riboflavin deficiency, 61% had pyridoxine deficiency, and 9.4% had thiamin deficiency as judged by enzymic tests. 2. The prevalence of angular stomatitis was 41.3% and that of glossitis was 18.2%. Biochemical deficien... | 465,434 | [
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Guar gum and reduction of post-prandial glycaemia: effect of incorporation into solid food, liquid food, and both. | 1. The influence of the dose and the form in which guar gum was given on the degree of "flattening" of blood glucose curves was studied in five subjects using meals of bread and soup containing 5 or 10 g guar gum. 2. When 5 g guar gum was added to bread the peak increase of blood glucose was reduced by 41% (P less than... | 465,440 | [
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A rapid method for the purification of supercoiled PM2 DNA by affinity chromatography on H1 histone covalently coupled to agarose. | A simple and rapid method is described for the purification of supercoiled PM2 DNA by affinity chromatography on columns of H1 histone covalently coupled to agarose. The method does not require the use of intercalating agents or ultracentrifugation procedures. Under the conditions most appropriate for purification, elu... | 465,493 | [
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Chemical modification of histidyl and lysyl residues in yeast enolase. | Modification of yeast enolase (2-phospho-D-glycerate hydro-lyase, EC 4.2.1.11) by diethyl pyrocarbonate at either pH 6.1 or 6.6 caused a biphasic inactivation of the enzyme. In the presence of excess Mg2+, either an equilibrium mixture of substrates or 3-phosphoglycerate, a competitive inhibitor, prevented the second s... | 465,507 | [
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Subcellular localisation of di- and tripeptidases in guinea pig and rat enterocytes. | Enterocytes were isolated from rat and guinea pig jejunum and subcellular fractions were prepared by density gradient centrifugation. Gradient fractions were assayed for principal organelle marker enzymes and for di- and tripeptidases. The hydrolases showed a dual localisation with both brush border and cytosol compone... | 465,509 | [
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Molecular weight and structural studies on cephalopod rhodopsin. | The protein moiety of squid (Watasenia scintillans) rhodopsin has been shown to have a molecular weight of 46 800 by means of amino acid analysis. This value was comparable to the value (51 000) obtained from SDS-polyacrylamide gel electrophoresis. After the squid eyes were incubated at 10 degrees C for 8 days, the rho... | 465,526 | [
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Mouse hepatoma and liver ferritins. Comparative structural studies. | Pure ferritin from male mouse liver produces a single band of monomers (RF = 0.199) with electrophoresis in polyacrylamide gels at pH 9.0. The five sub-bands within this monomeric band appear to represent charge isomers having the same molecular size. Ferritin from BH3 transplantable mouse hepatoma shows two overlappin... | 465,527 | [
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Selective extraction of desmosomal proteins by low ionic strength media. | Desmosomes, isolated using an acidic buffer, have been subjected to extraction at low ionic strength. This treatment removes more than 35% of their protein in the form of two polypeptide chains of molecular weight 210 000 and 230 000, but the desmosomes show only subtle changes in ultrastructure. It is concluded that t... | 465,533 | [
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The effects of EMG feedback training during problem solving: a case study. | The present case study investigated the effects of competing task demands on biofeedback training to reduce frontalis muscle tension. Baseline levels of frontalis muscle tension were recorded for relaxation and problem solving. The subject was trained to decrease muscle tension with biofeedback for the problem-solving ... | 465,580 | [
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[Properties of DNA-dependent RNA-polymerase from spleens of mice infected with Rauscher leukemic virus]. | The properties of RNA polymerases A, B and C isolated from the spleens of mice infected with Rauscher leukemic virus were studied. The solubilized RNA-polymerases A and B were purified 150--300-fold. The dynamic changes in the activities of all forms of RNA-polymerases at different stages of leukosis were studied. At t... | 465,605 | [
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[Isolation and some properties of ATP-dependent DNAse from sea urchin (Strongylocentrotus intermedius) embryo]. | An ATP-dependent DNAse was isolated from the cells of the sea urchin Strongylocentrotus intermedius embryos by chromatography on DEAE-cellulose and gel chromatography on Sepharose 4B. The enzyme was found homogeneous during polyacrylamide gel electrophoresis. The molecular weight of the enzyme was determined by gel fil... | 465,608 | [
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Neutralization of immune complex inhibition of antibody dependent cellular cytotoxicity in vitro by Staphylococcus-aureus protein A. | Staphylococcus-aureus protein A (SPA) incubated with sera containing immune complexes and effector cells increases antibody dependent cellular cytotoxicity (ADCC)and rosette formation. The enhanced ADCC and rosetting is due to SPA functioning as an IgG Fc cellular receptor. SPA binds to the Fc portion of Igg and has mu... | 465,637 | [
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Scanning molecular sieve chromatography of interacting protein systems. II. Determination of large zone transport parameters by the difference profile method at low solute concentration. | The experimental determination of difference profiles for the study of large zone transport processes by scanning molecular sieve chromatography is described. Using the difference profile method, the progesterone-induced purple glycoprotein of the porcine uterus was found to exist as monomeric units in high ionic envir... | 465,643 | [
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[Circardian rhythm of mitoses in the epithelium of the cornea after splenectomy]. | In corneal epithelium of CBA mice the index of colchicine mitoses diminished after splenectomy in the day period characterized by rising mitotic activity in control animals. The duration of active phase of cell division rhythm shortened while the maximum of mitotic activity delayed in comparison with control animals. T... | 465,695 | [
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[Effect of the balanced inhibition of DNA and protein synthesis on the in vitro and in vivo proliferative activity of the lymphocytes]. | Lymphocytes isolated from the rabbit peripheral blood were irradiated in vitro with 200, 400 and 1000 r doses and cultivated with phytohemagglutinin (PHA) doses and cultivated with phytohemagglutinin (PHA) at 37 degrees C during 48 hours. In several experiments cycloheximide, inhibiting protein synthesis, was added to ... | 465,696 | [
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[Differences between dose-effect curves for ethanol on locomotion and rearings in mice of various strains]. | Ethanol (1--5 g/kg, per os) dose-response curve for locomotion in male mice of 4 strains (SHR, BALB/c, C3HA and C57BL/6) is characterized by a gradual rise up to the top (at 3 g/kg for all strains except C3HA, in which it was attained at 5 g/kg) and by subsequent decline. The dose-response curve for rearings gradually ... | 465,715 | [
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[Electron microscopic study of the process of the removal of autogenous blood erythocytes beyond the limits of the subdural space]. | The internal plate of the dura mater and arachnoidea of the dob brain was studied by electron microscopy after introducing 0.3--0.5 ml of the autogenous blood into the subdural space. The arachnoidea of the excretory channels and structural elements of the internal plate of the dura mater (cells of the internal coverin... | 465,729 | [
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Immune suppression of erythropoiesis in transient erythroblastopenia of childhood. | Serum and IgG from four children with transient erythroblastopenia of childhood (TEC) was tested to see what effect it would have on development of erythroid colonies from bone marrow mononuclear cells. Serum and IgG specimens obtained at the time of diagnosis uniformly suppressed erythroid colony development from CFU-... | 465,738 | [
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[Antibody screening of commercially available immunoglobulins. Erythrocyte-, HLA- and autoantibodies (author's transl)]. | A great number of commercially available immunoglobulins was screened for erythrocyte-, HLA- and autoantibodies. Isoagglutinin titers were in general low, hemolysins were not detected. No preparation was found to contain detectable amounts of autoantibodies versus nuclei, mitochondria, smooth muscle or parietal cells. ... | 465,744 | [
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The development and evaluation of a small ready-reference library collection for a rural practice: a case study. | A demonstration core collection of twenty-four ready-reference sources and five journals was selected cooperatively by a solo practitioner in rural Menifee County, Kentucky, and the University of Kentucky Medical Center Library Field Librarian to fit the ready-reference and current awareness information needs of a prim... | 465,835 | [
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Effect of 5-hydroxytryptamine on protein synthesis in gastrointestinal and other tissues and on serum gastrin concentrations in rats. | 1 The effect of 5-hydroxytryptamine (5-HT) on protein synthesis in the gastrointestinal tissues as well as in the liver, heart and brain was studied by measuring [3H]-leucine incorporation into total tissue protein in vivo in rats. 2 A single injection of 5-HT (10 mg/kg) produced a marked inhibition (45 to 65%) in prot... | 465,872 | [
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... |
The effect of some general anaesthetics on the surface potential of lipid monolayers. | 1 This study sought to investigate the report by Ginsberg (1978) that 0.7 M ethanol brought about a + 100 mV change (DeltaDeltaV) in the surface potential of glyceryl monooleate (GMO) monolayers formed on KCl, although he predicted that a DeltaDeltaV of -10 mV should have been found.2 The effect of general anaesthetics... | 465,879 | [
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0.02936699,
0.01749637,
0.05135716,
... |
Temperature coefficients of affinity and entropies of adsorption from enantiomeric pairs of compounds acting at muscarinic receptors in the guinea-pig ileum. | 1 The affinities of a series of enantiomeric pairs of esters of phenylcyclohexylglycollic acid, of a pair of esters of alpha-methyltropic acid and of hyoscyamine methiodide have been measured for the muscarinic receptors of the guinea-pig ileum at 30 degrees and 37 degrees C and estimates have been made of their free e... | 465,895 | [
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0.264447,
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... |
Metaphyseal fractures in osteogenesis imperfecta. | Forty-one children with osteogenesis imperfecta have been reviewed. A minority (7/41) showed small metaphyseal fractures, resembling those seen in non-accidental injury, but in all of these there was obvious generalized bone disease so that confusion with non-accidental injury did not occur. | 465,918 | [
-0.4532759,
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0.1581531,
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0.2431425,
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0.0780... |
Oestrogen-induced renal carcinoma. | Oestrogen may be implicated as an aetiological factor in the development of some renal carcinomas in man. The development of a renal carcinoma in 2 patients who had been treated with low-dose oestrogen for periods of 3 and 3 1/2 years because of prostatic carcinoma is described. It is suggested that patients receiving ... | 465,965 | [
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0.3421583,
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Lateral curvature of the erect phallus without chordee. | Three cases of lateral curvature of the penis during erection are described. In no case was there evidence of chordee. A corrective operation for this condition is described. | 465,972 | [
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0.1996906,
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0.01312599,
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0.4938828,
0.03644032,
-0.09118... |
Acid phosphatase after examination of the prostate. | We report the effect of rectal examination of the prostate and transurethral resection of the prostate (TURP) on the serum level of tartrate labile acid phosphatase (TLAP) in 18 normal cases, 31 with benign enlargement of the prostate and 20 with carcinoma. Rectal examination had no effect on TLAP in normal patients, t... | 465,990 | [
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0.358033,
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0.02468034,
0.06128478,
-0.04964... |
Genitourinary tuberculosis: a 7-year review. | Since 1970 short course regimes of chemotherapy have been adopted for the treatment of 87 patients suffering from genitourinary tuberculosis. The response to chemotherapy, the effect of surgery, the importance of hypertension and the relapse rate have been studied. It is concluded that all cases of genitourinary tuberc... | 465,996 | [
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0.001689451,
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0.1941974,
0.2279424,
0.1567442,
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... |
Fracture of the penis with laceration of the urethra. | Two patients are described with severe injury to the penis sustained during sexual intercourse. The literature is reviewed. A conservative approach to management with suprapubic urinary diversion led to acceptable results. | 466,008 | [
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0.1897757,
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0.02837406,
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0.07500664,
0.1346499,
0.166225... |
Exploration of the common bile duct: a comparative study. | The results of a retrospective comparative study of 122 patients who underwent explorations of the common bile duct in a district general hospital over a 5-year period are presented. Seventy-eight patients had a supraduodenal choledochotomy, 32 had a transduodenal spincterotomy and 12 had a combination of both procedur... | 466,018 | [
-0.07503487,
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0.3383443,
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0.01990004,
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0.04774237,
0.1279754,
0.0845019... |
Primary hydatid cyst of the gallbladder. | An unusual case of hydatid cyst of the gallbladder is presented. The difficulties in diagnosis are discussed. There is no other report of such a cyst in the world literature. | 466,022 | [
-0.1418392,
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0.1105827,
0.034259... |
Distribution of plasma-bound hydroxyproline in breast cancer, benign breast disease and healthy females. | In normal adult females, patients with benign breast disease and patients with breast cancer, hydroxyproline (OHPro) was found in the plasma attached to the protein fractions which were separated by Sephadex gel filtration. In addition, a distinct moiety, probably a protein sub-unit, containing substantial amounts of t... | 466,035 | [
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0.2109371,
0.1210497,
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... |
Pancreatogram changes in patients with calculous biliary disease. | A successful pancreatogram was obtained at endoscopic retrograde cholangiopancreatography (ERCP) in 53 patients with calculous biliary disease. Twenty-eight patients presented with jaundice and 25 with pain. In both groups there was a high incidence of pancreatogram abnormalities (47 and 48 per cent respectively). Thes... | 466,038 | [
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0.2574881,
0.1778319,
0.1097156,
... |
Renal function after long-term treatment with lithium. | Daily urine volumes, plasma creatinine concentrations, and creatinine clearance were measured in 106 patients with unipolar and bipolar affective disorders attending a "lithium" clinic. Urine volumes exceeded 3.51 in only six patients, plasma creatinine concentrations exceeded 150 mumol/1 (1.7 mg/100 ml) in only five, ... | 466,057 | [
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0.524496,
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0.08028656,
0.2154095,
-0.1974228,
-0.0... |
Spinal-cord compression in myeloma. | Clinical records of 47 patients in whom spinal-cord compression was the presenting feature of plasma-cell myeloma were analysed retrospectively. Patients were referred during 1954-78. Median survival was 30 months and prognosis was best for those in whom the site of cord compression was the thoracic region. Early lamin... | 466,107 | [
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0.5427044,
0.2061312,... |
Autonomic neuropathy in rheumatoid arthritis. | Patients with seropositive and seronegative rheumatoid arthritis (RA) and age-matched controls were investigated for the presence of autonomic neuropathy. Significantly more patients with RA had abnormal autonomic function, suggesting that autonomic neuropathy occurs more commonly in RA than hitherto suspected. The exi... | 466,338 | [
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0.06060586,
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0.09278297,
-0.0010986... |
The discrete anatomical localization of vagal aortic afferents within a catecholamine-containing cell group in the nucleus solitarius. | The centripetal transport of horseradish peroxidase (HRP) was used to visualize the central projections of afferent fibers of the aortic arch nerve to the nucleus solitarius in pigeons. Our results indicate that aortic nerve afferents have a restricted distribution within one subdivision of the nucleus solitarius, desi... | 466,439 | [
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0.1923296,
0.2178024,
0.2207724,
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Neurochemical and morphological studies of bulk isolated rat brain cells. II. Preparation of viable cerebral neurons which retain synaptic complexes. | The bulk isolation from rat cerebral cortex of viable neurons retaining synaptic complexes is described. The basis of this procedure is to dissociate the neurons in situ from the surrounding glial cells. The glial structures that are normally adjacent to the neuronal cell body and to the proximal parts of the neuronal ... | 466,441 | [
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0.2323856,
0.093305,
0.3040062,
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0.09421875,
... |
Neuritogenic and chemical properties of guinea pig anterior and posterior root myelin. | In relapsing experimental allergic encephalomyelitis, recurrent demyelination was found in the anterior roots and dorsal root ganglia with minimal involvement of the posterior roots. To determine whether this is an antigen-related phenomenon, the distribution, type and intensity of the lesions in the proximal PNS of gu... | 466,442 | [
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0.03221034,
0.3679637,
0.02321018,
... |
Regeneration of normal terminal innervation patterns by central noradrenergic neurons after 5,7-dihydroxytryptamine-induced axotomy in the adult rat. | The regeneration of central adrenergic axons has been followed between 5 days and 18 months after 5,7-dihydroxytryptamine(5,7-DHT)-induced axotomy in the adult rat, using fluorescence histochemistry in combination with noradrenaline (NA) determinations and [3H]NA uptake measurements. The axonal and terminal degeneratio... | 466,444 | [
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0.1077259,
... |
Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. | Staggerer (sg) is a neurological mutant mouse in which the cerebellar granule cells degenerate after migration to the internal granule cell layer. In addition, the Purkinje cells are abnormal, being ectopic, smaller in size and without tertiary branchlet spines. In this study we report two new observations on this muta... | 466,453 | [
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0.2051244,
-0... |
Distribution of hypertrophied locus coeruleus projection to adult cerebellum after neonatal 6-hydroxydopamine. | Following treatment as neonates with a high subcutaneous dose of 6-hydroxydopamine (6-OHDA), the projections of the locus coeruleus were mapped in the brains of adult rats. This was done using the technique of unilateral lesions in the nucleus followed by simultaneous determinations of norepinephrine (NE) levels, dopam... | 466,465 | [
-0.1117919,
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0.1738104,
0.4098295,
0.3294902,
0.1372256,
-0.1623... |
Amplitude and fall-time discrimination of unit spike activity using TTL. | An inexpensive and reliable window discriminator simply constructed using TTL integrated circuits is described. The device will discriminate between unit spikes on the basis of amplitude alone or amplitude and fall-time, and simultaneous analysis of two separate spikes is possible. All pulse outputs and amplitude and f... | 466,487 | [
-0.10048,
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0.1499892,
0.2842623,
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0.2786708,
0... |
A note on the distribution of glial cells in the molecular layer of the dentate gyrus. | The distribution of the perikarya of astrocytes and other glial cells in the molecular layer of the dentate gyrus has been studied in gold chloride-sublimate preparations of rats and of normal and reeler mice, and in plastic embedded material from young adult rats. Contrary to previous reports (Rose et al. [7]), we hav... | 466,504 | [
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0.238998,
0.1385799,
0.... |
A study of the growth of the alimentary tract of the young cockerel. | 1. The growth of the alimentary tract of male domestic fowl has been described from measurements of the dry weight of the whole and component parts of the tract from hatching to 10 weeks of age. 2. Quadratic regression equations were derived to express the growth of the birds and the growth of their alimentary tracts. ... | 466,520 | [
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0.013107,
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0.04620565,
-0.09063653,
-0.31837... |
Acute airway obstruction: a complication of aluminum tape wrapping of tracheal tubes in laser surgery. | A case is reported of acute airway obstruction arising from the use of a tracheal tube wrapped with aluminum tape during laryngeal surgery with a carbon dioxide laser. Problems associated with aluminum tape wrapping of tracheal tubes are discussed. | 466,551 | [
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Relation of precurarization to suxamethonium to provide ease of intubation and to prevent post-suxamethonium muscle pains. | Tubocurarine 0.05 and 0.07 mg.kg-1, gallamine 0.1 and 0.2 mg.kg-1 and pancuronium 0.01 and 0.02 mg.kg-1 given three minutes before suxamethonium 1.0, 1.5 and 2 mg.kg-1 in groups of 10 patients each (total 210 patients) to compare ease of tracheal intubation and incidence of post-suxamethonium muscle pain. These were co... | 466,557 | [
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0.07307687,
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0.2439129,
0.0058038... |
Efficacy of helium--oxygen mixtures in the management of severe viral and post-intubation croup. | An appreciable number of children with viral or post-intubation croup progress to respiratory failure necessitating an artificial airway. We report seven such patients with critical airway narrowing in whom we reduced the work of breathing by developing helium rather than air as a carrier gas for oxygen. Assessment of ... | 466,564 | [
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Chronic pain syndromes and their treatment. II. Trigger points. | Trigger points are distinct areas of focal hyperirritability which give rise to areas of refered pain in well-defined areas of the musculo-skeletal system, sometimes remote from the point itself and not related to it by anatomically definable pathways. While the vast majority of pain manifestations from trigger points ... | 466,566 | [
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A "last ditch" airway. | In a patient whose airway is in jeopardy after unsuccessful attempts at conservative measures to clear it and after failed attempts at intubation, the intravenous tubing connector spike may be considered as an emergency percutaneous tracheostomy device. It is readily available wherever physicians have intravenous solut... | 466,569 | [
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Factors affecting the encapsulation of drugs within liposomes. | The reported efficiencies of drug encapsulation into liposomes range from less than 0.1% to more than 10% per micromole phospholipid, depending on the nature of the drug and of the liposome employed. We have sought to investigate some of the factors which control the efficiency of drug encapsulation. We have found that... | 466,580 | [
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Dietary fibre and colonic neoplasia. | Dietary plant fibre, or plantix, is thought to play a significant role in the pathogenesis of colon cancer in humans. It is a complex polymeric substance that has several distinct components resistant to hydrolysis by the digestive enzymes of humans. These components include cellulose, hemicelluloses, pectins, lignin, ... | 466,603 | [
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Report of a clinical trial of a Canadian preparation of antihemophilic factor. | A clinical trial of a Canadian preparation of antihemophilic factor has been completed. The mean percentage increase in the factor VIII coagulant activity in the plasma was determined to be 2.1 +/- 0.8 per unit per kilogram dose, which compares very favourably with published data. The mean half-life of antihemophilic f... | 466,616 | [
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Effect of a forced diuresis on the distribution and excretion (via urine and bile) of 195mplatinum when given as 195mplatinum cis-dichlorodiammineplatinum(II). | 195mPlatinum cis-dichlorodiammineplatinum(II) (195mPt cis-DDP) was injected iv with furosemide or mannitol into male Sprague-Dawley rats. The effect of such a diuresis on the distribution, excretion, and retention of cis-DDP was measured. The mannitol-treated animals had a significant increase in the urinary excretion ... | 466,654 | [
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A comparison of receptive and non-receptive plasma membrane areas of photoreceptor cells in the leech, Hirudo medicinalis. | Microvillar (receptive) and external (non-receptive) portions of the plasmalemma of photoreceptor cells of Hirudo were compared electron microscopically in thin sections and freeze-fracture replicas. A morphometric approximation showed that the surface area of the microvillar membrane is about 19 times larger than that... | 466,675 | [
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Synaptogenic effect of estrogen on the hypothalamic arcuate nucleus of the adult female rat. | In order to examine the effect of estrogen on the synaptic structures in the hypothalamic arcuate nucleus (ARCN), semi-quantitative studies were performed by counting synapses in an 18,000 micron 2 area in the middle part of the ARCN in each brain. In ovariectomized female rats injected with 2 micrograms of estradiol b... | 466,679 | [
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Formation of sarcomeres in the embryonic heart of the lobster. | Cardiomyoblasts in the myocardium of embryonic lobsters at 3-4 weeks and 6 months of development were examined with the transmission electron microscope in order to describe the events in the formation of sarcomeres in a neurogenic cardiac system. Thick and thin myofilaments appear first in the cell periphery near the ... | 466,684 | [
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DNAase hydrolysis of chromatin DNA in intact sea urchin sperm cells. Effect of the ionic strength on the digestion parameters. | Chromatin DNA in intact functional Sphaerechinus granularis sperm cells has been digested with micrococcal nuclease at three different ionic strength conditions. The results show a highly-flexible chromatin organization similar to that found in sperm heads. The rate of digestion, the limit value of acid-soluble materia... | 466,707 | [
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Dose and effect of methyl-2-benzimidazolylcarbamate in the "mammalian spot test", an in vivo method for the detection of genetic alterations in somatic cells of mice. | In the spot test, mouse embryos which are heterozygous for four different recessive coat-colour genes are treated in utero by injection of a mutagen into the peritoneal cavity of the mother or by other appropriate routes of administration. If this treatment leads in a pigment precursor cell to an alteration of the wild... | 466,741 | [
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Action research and evaluation: can research and practice be successfully combined? | Educative intervention with the young severely subnormal child and his family is envisaged as an example of 'action research' in which the dual roles of the practitioner-researcher and the client-subject are examined. A view of the effect of the interaction of these roles on the intervention and its evaluation is given... | 466,749 | [
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Improved automated kinetic determination of uric acid in serum by use of uricase/catalase/aldehyde dehydrogenase. | The enzymatic determination of serum uric acid by use of uricase, catalase, and aldehyde dehydrogenase according to Haeckel [J. Clin. Chem. Clin Biochem. 14, 101 (1976)] showed interferences from ethanol-converting enzymes, which are present in some patients' sera. We have identified these enzymes as alcohol dehydrogen... | 466,770 | [
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Catalase, superoxide dismutase, glutathione reductase and thiobarbituric acid-reactive products in normal and dystrophic human muscle. | The level of thiobarbituric acid-reactive products and the specific activities of catalase and glutathione reductase were significantly higher in muscles from patients with major forms of muscular dystrophies over those of control subjects. Superoxide dismutase activity was not altered in dystrophic muscles. These find... | 466,816 | [
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Orthostatic postural activity disorders recorded by statokinesimeter in post-concussional syndromes: oculomoter aspect. | The purpose of this paper is to emphasize the influence of the mesencephalic oculomotor system regulation on orthostatic postural regulation. The body at rest is never immobile but it swings continuosly. The amplitudes and the frequencies of body sway give an indication of the function of the different sensorimotor loo... | 466,840 | [
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Complement activation in asymptomatic patients with sickle cell anaemia. | Previous reports have suggested that a defect in serum complement may contribute to the increased susceptibility to infection shown by patients with sickle cell anaemia (SCA). In order to define the nature of any complement abnormality in SCA, we investigated the complement system in eighty-seven patients during asympt... | 466,858 | [
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Ambulatory evaluation and treatment of infertile couples. | With the exception of major surgical procedures, all investigative and therapeutic regimes regarding infertility can be instituted and carried to completion via the ambulatory office and hospital route if a foundation for understanding and cooperation between the physician and the couple is established during the initi... | 466,888 | [
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Assessment of left ventricular function in aortic insufficiency using echocardiography, gated scintigraphy and contrast angiography. | Echocardiography, gated scintigraphy and contrast angiography were used to measure left ventricular ejection fractions in 20 patients with varying degrees of aortic insufficiency. There was good correlation between the radionuclide and the angiographic ejection fractions. Echocardiographic ejection fraction correlated ... | 466,900 | [
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Usefulness of 99mTc-methylene diphosphonate scintigraphy in nephrocalcinosis. | Abnormally increased uptake of 99mTc-methylene diphosphonate in the kidney parenchyma was found in a patient with acutely exacerbated sarcoidosis. The findings could be related to active sites of nephrocalcinosis. | 466,914 | [
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Vacuum contoured, liquid crystal, dynamic breast thermoangiography as an aid to mammography in the detection of breast cancer. | New thermographic equipment is introduced in the form of liquid crystals embedded in flexible, transparent, elastomeric sheaths which may be vacuum contoured to any breast. Dynamic thermoangiography, a new physiological method of performing thermography with these liquid crystal sheaths, is presented. Thermographic cha... | 466,939 | [
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Absence of oesophageal mucosal folds in systemic sclerosis. | In a controlled study of barium swallow radiographs in systemic sclerosis, longitudinal oesophageal mucosal folds were absent in eight of 30 patients and in one of 30 control subjects (P less than 0.03). Patients without mucosal folds developed Raynaud's phenomenon at an earlier age than those who retained their mucosa... | 466,950 | [
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Arsenic exposure in multiple environmental media in children near a smelter. | A nationwide survey of heavy-metal exposure in children living near primary nonferrous metal smelters demonstrated high urine arsenic levels in children living near a copper smelter in Ajo, Arizona. Airborne smelter emissions and drinking water were the apparent sources of exposure. To determine whether increased arsen... | 466,981 | [
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LOGIT: a program for dose-response analysis. | We describe a FORTRAN computer program for fitting the logistic distribution function: (formula: see text) Where x represents dose or time, to dose-response data. The program determines both weighted least squares and maximum likelihood estimates for the parameters alpha and beta. It also calculates the standard errors... | 467,012 | [
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An interactive toxicological data handling system for a PDP-12 computer. | This paper describes a program developed for the cataloguing, storage and retrieval of toxicological data. The user can, through dialogue with the program, enter and update data, and request reports with statistical analyses. The system is written in the FOCAL-12 language for a PDP-12 laboratory computer, and is suitab... | 467,014 | [
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Nickel allergy and osteomyelitis in a patient with metal osteosynthesis of a jaw fracture. | A 27-year-old female, after a fracture of the mandible treated with osteosynthesis and after a difficult extraction, developed osteomyelitis with fistulation and sequestration. Sequestrectomy and extraction of the teeth in the osteomyelitic area did not clear the patient of symptoms. A patch test to nickel turned out t... | 467,023 | [
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Hot water as a tubal occluding agent. | Experimental studies in living rabbits and autopsy human oviducts are presented which demonstrate a reasonable possibility that one could introduce hot water into the proximal portion of the human oviduct with a hysteroscope or balloon catheter, to destroy the epithelium of the first portion of that structure, leading ... | 467,052 | [
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Prostaglandin E1 infusion in the hypoplastic left heart syndrome. | Aortic infusion of prostaglandin E1 in a moribund infant resulted in marked clinical improvement. Appropriate studies were conducted and the diagnosis of hypoplastic left heart syndrome was made. Although the outcome was unaltered, the improved clinical condition allowed us to exclude potentially curable defects such a... | 467,122 | [
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Comparative study of a standardized senna liquid and castor oil in preparing patients for radiographic examination of the colon. | X-Prep Liquid, used as a radiologic bowel evacuant, was found to be more effective, better tolerated, and more readily accepted than castor oil. The efficacy of a single full dose of this peristaltic stimulant was confirmed, and a divided dose of X-Prep Liquid was practically as effective and produced less griping and ... | 467,206 | [
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-0.02376839,
... |
[Frequency of life-threatening complications associated with exercise testing (author's transl)]. | Most of the statistics on complications of ergometric exercise tests come from the United States and are largely related to treadmill ergometry. A questionnaire was sent in the summer of 1978 to 198 investigative units in the German-speaking regions. The results of 1065 923 person-tests were made available. Exercise te... | 467,275 | [
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0.3319953,
0.1095759,
0.3753997,
0.0838... |
[Secretion of growth hormone in pigs]. | Spontaneous rhythmic changes of growth hormone concentration were observed in plasma of pigs, ranging between 30 and more than 100% as compared to the initial values. These rhythmic changes should be considered when plasma GH is determined. | 467,356 | [
-0.1053634,
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0.009518311,
-0.05230895,... |
Studies on the effects of ethinyl estradiol and norethisterone acetate on the adrenal cortex and some other tissues in the rat. | Alkaline phosphatase activity (AP) of the adrenal cortex of rats were determined under the effect of ethinyl estradiol (EE) and/or norethisterone acetate (NA), the two components of the contraceptive pill gyn-anovlar (Schering AG Berlin). A pathological study was also carried out to examine the effects of EE and NA on ... | 467,363 | [
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0.4831621,
0.3456137,
0.3092474,
0.0009073643,
0.01... |
Intra- and extravascular volume changes in the human forearm after static hand grip exercise. | Studies have been conducted to evaluate intra- and extravascular volume changes and blood flow in the exercising human forearm by means of (1) combining plethysmographic and scintigraphic methods, (2) an indirect procedure using the relationship of blood flow and volume change from reactive hyperemia. A static hand gri... | 467,412 | [
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0.2591905,
0.08050363,
0.02500631,
0.1089566,
-... |
Serial isometric contractions under imposed myotatic stretch conditions in high-strength and low-strength men. | The immediate effects of an imposed myotatic stretch on knee extensor force were studied in 12 high-strength and 12 low-strength men. Under nonfatigued pre-exercise conditions, significant tension increases of 6.5% for the high-strength group and 11.0% for low-strength subjects were observed as a result of the imposed ... | 467,414 | [
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-0.028405,
-0.09456325,
0.1370557,
0.146... |
Post-competition blood lactate concentrations in collegiate swimmers. | The purpose of this investigation was to quantitate post-competition lactate (LA) concentrations of swimmers during a competitive collegiate meet. Blood LA was measured by an enzymatic method on 23 subjects 5 min after each race event. The largest mean LA concentration of 25.7 mM/L was observed in swimmers after compet... | 467,416 | [
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0.1237129,
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0.09187339,
0.433846,
0.2211755,
-0.007482509,
... |
The excision of N-methyl-N-nitrosourea-induced lesions from the DNA of Chinese hamster cells as measured by the loss of sites sensitive to an enzyme extract that excises 3-methylpurines but not O6-methylguanine. | An enzyme extract from Micrococcus luteus excises 3-methyladenine and 3-methylguanine but not O6-methylguanine, 7-methylguanine, 1-methyladenine or 7-methyladenine from DNA reacted with N-methyl-N-nitrosourea. The extract was used to detect lesions in the DNA of Chinese hamster cells treated in culture with N-methyl-N-... | 467,426 | [
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0.2129629,
0.2290022,
0.3240184,
0.3013618,
0.1941157,
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0.... |
Identification of the translation products of human fibroblast interferon mRNA in reticulocyte lysates. | Messenger RNA was purified from human foreskin fibroblasts FS11, a high interferon-producer line, after induction with synthetic double-stranded RNA. The mRNA was translated in a cell-free protein-synthesis system from rabbit reticulocytes. The translation products, containing biologically active human interferon, were... | 467,436 | [
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0.0561573,
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0.2426734,
0.4228008,
0.01856231,
-0.3449006,
... |
Transcription activity of a DNA-protein complex isolated from spinach plastids. | A DNA . protein complex of about 150 S is isolated from purified spinach chloroplasts by Sepharose 4B gel filtration. A DNA-dependent RNA polymerase activity is found associated with the complex. This DNA protein complex is able to initiate RNA chains in vitro. The RNA synthesis is more dependent on CTP than other nucl... | 467,444 | [
0.1397746,
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0.0146945,
0.3243393,
0.7764597,
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0... |
Distribution of polypyrimidine . polypurine segments in DNA from diverse organisms. | Polypyrimidine . polypurine segments are regions of duplex DNA which contain a highly asymmetric distribution of pyrimidine and purine nucleotides. A polypyrimidine in single-stranded DNA can be detected by its ability to form a complex and poly(A, G) which will bind to hydroxyapatite. We tested DNA from a variety of o... | 467,445 | [
0.06453899,
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0.2986143,
0.2680965,
0.1387016,
0.5863005,
0.1947982,
-0.1917186,
0.0190... |
Isolation and characterization of a sulfated glyceroglucolipid from alveolar lavage of rabbit. | A major acidic glycolipid of the rabbit alveolar lavage has been isolated and characterized. The isolation procedure involved extraction of lipids, column fractionation on DEAE-Sephadex and silicic acid, and thin-layer chromatography. Chemical analysis of the glycolipid revealed the presence of glucose, fatty acids, gl... | 467,447 | [
0.1171212,
0.2611828,
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0.3847343,
0.3048745,
0.1526106,
0.2716326,
-0.13915... |
Pharmacokinetics of intravenous amikacin after rapid and slow infusion with special reference to hemodialysis. | The pharmacokinetics of amikacin, a recently introduced aminoglycoside structurally related to kanamycin, were determined in healthy volunteers after rapid and slow constant-rate intravenous administration of a 7.5 mg/kg dose. The elimination profile of amikacin can be described by two compartment open model kinetics. ... | 467,467 | [
-0.2647524,
0.08829851,
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0.237059,
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0.255493,
0.0701831,
0.2013948,
0.07679... |
An analysis of the stimulant effects of 5-hydroxytryptamine on isolated, blood-perfused rat heart. | In rat isolated hearts perfused at a fixed low rate, single injections of 5-hydroxytryptamine (5-HT) (0.1--3 microgram) into the coronary perfusion produced dose-dependent increases in left ventricular (LV) dP/dt max and perfusion pressure (PP), but no clear changes in heart rate. The increases in the LVdP/dt max and P... | 467,497 | [
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0.03765434,
0.04812297,
0.3220141,
0.1562024,
0.2582306,
-0.06689128,... |
Recovery of renal lactate dehydrogenase (LDH) isoenzyme pattern after obstruction relief in experimental hydronephrosis. | The release of ureteral occlusion leads to a progressive recovery in LDH isoenzyme pattern with gradual increase of anodic fractions and decrease of middle and cathodic ones. Our findings demonstrate that the recovery is accomplished on the 10-14th day, in agreement with morphological and metabolic observation. | 467,572 | [
-0.01902994,
0.02412532,
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0.1038494,
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0.03281195,
0.230136,
0.1585266,
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... |
Velocity gradient and contraction frequency of the pyeloureteral system. | An optical detection method, using video imaging, is used to quantitatively record the frequency and velocity profile of the renal pelvis of the rabbit. It is demonstrated that concentric waves originating at the periphery of the pelvis have an initial velocity of 3.2 cm/sec, accelerating toward the pelviureteral junct... | 467,592 | [
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0.6428946,
-0.02168827,
-0.124... |
Choleretic and cholestatic effects of infused bile salts in the rat. | In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20-50%. However, at high infusion rates (5-20 mumoles min-1kg-1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was s... | 467,601 | [
-0.03400812,
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-0.163276,
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0.06306782,
0.06970257,
0.2943548,
0.03923065,
0.2460452,
0.244667,... |
[Synthesis of O-(beta-diethylaminoethyl)cinchoninaldoxime with local anesthetic activity]. | The synthesis and the pharmacological evaluation of a new series of O-(beta-diethylaminoethyl)aldoxines derived from cinchonine-aldehydes substituted at position 2 by alkyl and alkoxyl groups are described. | 467,628 | [
-0.08074129,
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0.338573,
0.1827177,
0.3873036,
0.146321,
0.09174444,
-0.1315775... |
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