title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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4-Methyl-2-oxopentanoate oxidation by rat skeletal-muscle mitochondria. | 1. Oxidative decarboxylation of 4-methyl-2-oxopentanoate (2-oxoisocaproate) by mitochondria of rat skeletal muscle showed biphasic kinetics. Two apparent Km values of 9.1 micronM and 0.78 mM were established. In broken mitochondria the rate of oxidation was lower and only the higher apparent Km value was found. 2. Isov... | 508,289 | [
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Activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in homogenates of developing rat brain. | The specific activity of 3-hydroxy-3-methylglutaryl-CoA reductase increases when homogenates of developing rat brain are incubated at 37 degrees C or kept on ice. This increase is completely blocked by the addition of F- to the homogenization medium and the assay mixture. The capacity for activation of the reductase is... | 508,290 | [
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Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover. | 1. Rates and rate coefficients of glucose utilization and replacement (glucose turnover) as well as its recycling were determined in rats by using [U-14C]- and [2-3H]-, [3-3H]- or [6-3H]-glucose. 2. In euthyroid rats, the blood concentration of glucose was 1.5 times and its turnover rate was 2 times as high in the fed ... | 508,298 | [
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Total fasting and postprandial serum bile acids determination by 3 alpha-hydroxysteroid dehydrogenase in normal subjects. | Total serum bile acids (SBA) have been evaluated in 28 healthy subjects by an enzymatic-fluorimetric method using the enzyme 3 alpha-hydroxysteroid dehydrogenase. The healthy subjects showed a value of 2.78 +/- 1.84 microM/1 (mean +/- SD), ranging 0.5 to 4.7 microM/1. In addition, two hours postprandial evaluation of S... | 508,420 | [
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[Air embolism due to limited high grade barometric depression as evidenced in vivo]. | The Authors supply documentary evidence for the aeroembolism of auricular lobe vessels photographed in transillumination of living albino rabbits exposed to high grade barometric depression (850 g/cm2) limited on the top of the head. | 508,430 | [
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[Morphological changes of platelets in disturbed cerebral microcirculation--a clinical study using a scanning electron microscope (author's transl)]. | Many factors are known that contribute to the pathogenesis of the cerebral microcirculatory disturbances, but, there are few reports investigating the roles of the intravascular components directly. The present study was undertaken to evaluate morphological changes of platelets in patients with cerebral damage, in rela... | 508,443 | [
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[Sphenoethmoidal meningoencephalocele associated with agenesis of corpus callosum and median cleft lip and palate--report of two cases (author's transl)]. | Two cases of sphenoethmoidal meningoencephalocele are reported. Patients are a 1 year 7 month old boy and a 3 year old boy. Although sphenoethmoidal meningoencephalocele is reasonably classified as a type of basal meningoencephalocele, the authors could not find out any reports on cases designated as such. The reason m... | 508,444 | [
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Projection of electrocardiographic signs in praecordial maps after exercise in patients with ischaemic heart disease. | Praecordial surface maps of the electrocardiogram were recorded before and after exercise using 16 electrodes covering the left hemithorax. The ST segment and R and S wave changes were measured in the praecordial maps from 20 individuals with no detectable cardiovascular disease. These showed no significant alteration ... | 508,472 | [
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Syndrome of valvular pulmonary stenosis and valvular aortic stenosis with atrial septal defect. | Clinical and morphological findings are described in 2 adults with combined valvular pulmonary and aortic stenosis with atrial septal defect, an extremely rare combination of lesions. The direction of the shunt via the atrial septal defect in this combination appears to be dependent on the relative degree of outflow ob... | 508,476 | [
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Inhibition of neuronal and extraneuronal uptake of noradrenaline by ketamine in the isolated perfused rat heart. | The effect of ketamine on the uptake of 3H-noradrenaline in the isolated perfused rat heart was studied. A dose-dependent inhibition of uptake by both neuronal and extraneuronal processes was found. These effects may account for the positive chronotropic and pressor effects of the drug. | 508,488 | [
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Metabolic effects of induced hypotension with trimetaphan and sodium nitroprusside. | In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, ... | 508,494 | [
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Blood pressure reduction by incremental infusion of labetalol in patients with severe hypertension. | 1. Labetalol was given by incremental intravenous infusion to nineteen severely hypertensive patients, of whom nine were refractory to previous oral antihypertensive therapy. 2. Smooth reduction of arterial pressure was achieved in twelve subjects; one remained resistant to labetalol up to 160 mg/h; a sudden fall in pr... | 508,511 | [
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The effect of intravenous disopyramide phosphate on recurrent paroxysmal tachycardias. | 1 Reccurent paroxysmal atrial, atrioventricular and ventricular tachycardias in 50 patients without acute coronary insufficiency, heart failure or metabolic abnormlity were treated with disopyramide phosphate in a dose of 2 mg/kg body weight infused over 5 min. 2 Conversion to sinus rhythm within 10 min of the complete... | 508,548 | [
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The interaction of varying doses of dipyridamole and acetyl salicylic acid on the inhibition of platelet functions and their effect on bleeding time. | 1 In normal volunteers maximum reductions in platelet functions, collagen aggregation, adhesion and PF4 availability, were achieved using combined doses of 50 mg three times daily dipyridamole + 180 mg ASA or 75 mg three times daily dipyridamole + 120 mg ASA daily. 2 These doses did not prolong the bleeding time. 3 A s... | 508,556 | [
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Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer. | Electrophoresis of cytosol prepared from normal and malignant tissue samples of uterine cervix and endometrium revealed interesting differences which may be relevant to the characteristic alterations in glucose metabolism associated with tumour development. Hexokinase II was detected in 30% of the cancer material from ... | 508,567 | [
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Competition between foetal tissue and macrophage-dependent natural tumour resistance. | Prolonged interaction in vitro between C. parvum-induced adherent predominantly phagocytic rat peritoneal cells and syngeneic or xenogeneic tumour targets consistently produces marked cytotoxicity. In the presence of irradiated foetal liver cells, expression of cytotoxicity is blocked in a dose-dependent manner. The ab... | 508,568 | [
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Myocardial infarction in spontaneously hypertensive rats with superimposed adrenal-regeneration hypertension. | The elevated blood pressure of spontaneously hypertensive rats (SHR) was further exacerbated by subjecting these animals to surgically induced adrenal-regeneration hypertension (ARH). When chronic abnormally high blood pressure had been in effect for 12 weeks, the animals were subjected to an acute and massive myocardi... | 508,586 | [
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The normal trichogram of pubic hair. | The parameters of the trichogram of the pubic hair were studied with a previously described technique. Measurements were made on males and on non-pregnant, pregnant and post-partum females. In males and non-pregnant females denisty and rate of growth steadily decrease with age. There was a higher percentage of telogens... | 508,610 | [
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Aggressive basal cell carcinoma in Nigerians. | It is important to emphasize that basal cell carcinoma occurs in black Africans, a fact denied in some reports. The present study shows that the disease appears to behave more aggressively in the African, particularly in albinos, than in Caucasians. In albinos preventive measures should be employed regularly. | 508,614 | [
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Viability of red cells stored in diminished concentration of citrate. | A comparison was made between the post-transfusion survival of red cells stored in standard ACD-A and in modified ACD-A, containing two-thirds the amount of citrate. Measurements of survival after 28 d storage in both solutions were made in each of six subjects. Mean post-transfusion survival with the two solutions was... | 508,622 | [
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Transitional myeloproliferative disorder. | Eleven patients have been observed with clinical features of both polycythaemia vera and myelofibrosis. Detailed follow-up and repeated haematological and isotopic investigations, including the assessment of erythropoietic distribution by 52Fe scanning, over a 10 year period, have indicated that patients who initially ... | 508,626 | [
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The effect of iron deficiency on whole blood viscosity in polycythaemic patients. | Iron deficiency leads to a significant increase in whole blood viscosity in polycythaemic patients. This can be corrected by simultaneous treatment with iron and venesection. In patients with polycythaemia secondary to hypoxia the haemoglobin concentration may be increased by treating coexisting iron deficiency, withou... | 508,628 | [
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Junctional structures in haemopoiesis: a study of bone marrow using freeze-fracture and lanthanum impregnation techniques. | Intercellular regions of contact in the haemopoietic compartment of normal rat bone marrow were studied using freeze-fracture and lanthanum tracer techniques. Small adhering junctions (like desmosomes and their variants) were found between haemopoietic and stromal cells but tight, gap or septate junctions could not be ... | 508,632 | [
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UK Naval Dockyards asbestosis study: survey of the sample population aged 50-59 years. | As part of a general morbidity study of all civilian employees in the four Royal Naval Dockyards, the clinical, radiological and physiological effects of exposure to asbestos in 1200 men aged 50-59 years were studied in detail. The sample included all men on the Register of Asbestos Workers, one in three of those curre... | 508,640 | [
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The border between the paranoid-schizoid and the depressive positions in the borderline patient. | In this paper some of the mental mechanisms deployed by borderline patients are described and illustrated with clinical material. It is suggested that the term borderline has three distinct but related meanings. First, it refers to a clinical category of patients, borderline between neurosis and psychosis who, while no... | 508,654 | [
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The effect of menopausal status and sequential mestranol and norethisterone on serum cholesterol, triglyceride and electrophoretic lipoprotein patterns. | The serum cholesterol, triglycerides and electrophoretic lipoprotein patterns of 35 postmenopausal women, who subsequently received sequential mestranol and norethisterone, were compared with those of 35 premenopasual women of the same age and weight. The postmenopausal women had a significantly higher level of serum c... | 508,663 | [
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Amniotic fluid squalene and fetal maturity. | Gas chromatographic profiles of neutral lipids in amniotic fluid pellets were analysed for 51 specimens collected from patients in the last two months of pregnancy. The most noticeable change was a large increase in squalene relative to other components in samples at term. By expressing data as a ratio of squalene to c... | 508,672 | [
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Cauterising iris scissors. | The cauterising iris scissors described here are a modification achieved by suitably insulating the standard De Wecker's iris scissors. This modification provides in addition to cutting an advantageous cauterising effect, which could prove useful in the surgery of eye conditions with high risk of bleeding or metastasis... | 508,691 | [
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-0.1034559,
-0.7404004,
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-0.3777792,
-0.05722746,
0.07559714,
-0.3385037,
-0.02797761,
-0.1775355,
-0.20110... |
Interference of 50 Hz electrical cortical potentials evoked by TV systems. | Application of TV systems for generating patterned stimuli for the examination of the electrical cortical potentials has disadvantages caused by the frame frequency of 50 Hz of TV sets. Apart from a larger variability in latency times of the electrical potentials as compared to the results obtained by projector systems... | 508,694 | [
0.02034783,
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0.2356891,
-0.07216548,
... |
Gentamicin penetration and decay in the human aqueous. | The penetration of gentamicin into human aqueous was measured after intensive drops or subconjunctival injection of the antibiotic. The drop regimen proved ineffective in producing a therapeutically effective level. After a single 40 mg subconjunctival injection an effective concentration was achieved in 2 hours and ma... | 508,697 | [
-0.05553493,
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0.2808668,
0.2721397,
0.1234341,
0.4688371... |
Factors affecting the voluntary intake of food by sheep. 2. The role of distention and tactile input from compartments of the stomach. | 1. Sheep equipped with rumen and abomasal cannulas were given ad lib. access to ground and pelleted lucerne (Medicago sativa) hay except for periods of up to 6 h immediately before experimental sessions in which food intake was measured while various stomach compartments were either distended or subjected to tactile st... | 508,706 | [
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0.1072173,
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0.0184428,
0.3098078,
0.1351182,
-0.006063... |
Estimation of heat production from heart-rate measurements in cattle. | 1. Heat production and heart rate of seven steers were measured simultaneously using either a calorimetric chamber or head-cage. 2. The relationship between heat production and heart rate for each animal was best described by linear regression. 3. Differences between individual animals made separate 'calibration equati... | 508,711 | [
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0.3716854,
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0.001266052... |
The mechanism of passage of endogenous urea through the rumen wall and the role of ureolytic epithelial bacteria in the urea flux. | 1. The rumen urea concentration in gnotobiotic lambs lacking ureolytic bacteria was equal to that of blood. 2. Bacterial urease (EC 3.5.1.5) activity in sheep fed by intraruminal and intra-abomasal infusion was inversely related to rumen ammonia concentration. 3. A model is proposed for the facilitation and control of ... | 508,714 | [
-0.4284413,
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-0.3471065,
0.24749,
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-0.07064149,
... |
86Rb+ fluxes in Chinese hamster ovary cells as a function of membrane cholesterol content. | Steady-state fluxes of 86Rb+ (as a tracer for K+) were measured in Chinese hamster ovary cells (CHO-K1) and a mutant (CR1) defective in the regulation of cholesterol biosynthesis; the membrane cholesterol content of this mutant was varied by growing it on a range of cholesterol supplements to lipid-free medium (Sinensk... | 508,750 | [
-0.1638894,
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0.142346,
0.4649356,
-0.0483085,
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... |
Hydroxyapatite chromatography of short single-stranded DNA. | Short single-stranded segments of calf thymus DNA were obtained by random cleavage with DNAase I. After treatment with various concentrations of DNAase I, fragment sizes were estimated using the ratio of total to terminal phosphorus. DNA populations ranging from 4--180 bases were obtained. Fragments with lengths up to ... | 508,758 | [
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0.08710772,
0.0513407,
0.5651267,
0.008648203,
-0.2941875,... |
The presence of citrulline in epidermal proteins. | Citrulline is present in the stratum corneum proteins of human, cow snout, pig snout and guinea pig epidermis but is absent from the stratum corneum proteins of frog, mouse, turtle, rat and hamster epidermis. The amino acid is released by acid hydrolysis and ranges from 1.7 to 5.5 residues per thousand residues of prot... | 508,789 | [
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0.09030347,
0.01419904,
-0.07942865,
0.1999042,
0.09543068,
-0.07582951,... |
Evidence for a structural role for chlorophyll in chlorophyll-protein complexes. | 1. Chymotrypsin treatment of spinach chloroplast membranes does not change the electrophoretic mobility of either chlorophyll-protein complex 1 or 2. 2. The extraction of lipids with 80% acetone after treatment of the membranes with chymotrypsin reveals that the polypeptide components of both chlorophyll-protein comple... | 508,798 | [
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0.3940625,
0.1047555,
0.3417844,
-0.225796,
-... |
Bovine type I collagen: A study of cross-linking in various mature tissues. | The cyanogen bromide peptides from insoluble and pepsin solubilised type I collagen of bovine bone, dentine, meniscus, tendon, skin and cornea were compared by SDS-polyacrylamide gel electrophoresis. In each case alpha 1CB6 was shown to be the only peptide of molecular weight greater than 10 000 involved in cross-linki... | 508,799 | [
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0.4209555,
0.3182523,
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0... |
[Relationship between incurrent flow, calcium ion concentration and membrane potential]. | A dependence of the inward current across the cell membrane giant neurones at garden snail was investigated under voltage champ. It has been concluded that there are two components of the inward current: a calcium-dependent and I0. The latter current probably was carried by sodium ions. The inward Ca current (ICa) is t... | 508,820 | [
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0.... |
[Infrared spectroscopic study of DNA--lipid interactions. DNA compacting on disperse particles]. | Within the range of relative humidity (r. h.) 0 to 92% there were obtained IR-spectra (4000--900 cm-1) of undeuterated and deuterated films of rat liver lipids, both in the free state and in the complex with native (nDNA) and heat-denaturated DNA (dDNA). Found peculiarities of IR-spectroscopic realization of the comple... | 508,839 | [
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0.2798059,
0.3649634,
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... |
Nonlinear dynamics of paleocortex manifested in the olfactory EEG. | The olfactory bulb is the first central component in a highly sensitive yet markedly stable sensory system. It receives a surge of receptor activity with each inspiration and transmits output as a brief burst of oscillatory activity that is most clearly seen in the EEG. These properties together with the known anatomy ... | 508,848 | [
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0.124544,
0.2333098,... |
[Two sites of ubisemiquinone binding in mitochondrial succinate oxidase]. | The inhibiting effects of several phenol compounds on electron transfer in the respiratory chain of submitochondrial particles were studied. It was shown that the terminal part of the succinate dehydrogenase complex contains a site, which specifically binds the negatively charged phenols (e. g. pentachlorophenol, 2,4-d... | 508,859 | [
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0.07961493,
0.1170265,
0.1531395,
0.0984892,
0.1149348,
0.05563... |
Changes in neuropsychological performance during treatment for alcoholism. | A battery of 24 neuropsychological tests was administered to drug-free alcoholic inpatients (n = 91) within 7 days of their last drink and again 17 days later. Comparisons between this group and a nonalcoholic group of medical inpatients (n = 20) also given the same test battery twice indicated very little improvement ... | 508,885 | [
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0.3709341,
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0.1226374,
0.01909909,
... |
Anti-tumour effect of an aromatic retinoic acid analog in a mouse syngeneic transplantable sarcoma. | Anti-tumour activity of an aromatic retinoic acid analog has been tested on Sarcoma J in syngeneic system. Tumour complete regression rate and median survival time of progressors mice are significantly improved. These results are at variance with previous observations suggesting the lack of activity of this compound on... | 508,892 | [
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0.02897919,
0.3516633,
0.2994481,
0.0389504,
-0.4586734,
0.1... |
Nylon-fiber-induced neutrophil fragmentation. | We have investigated the effects of mechanical elution of neutrophils from nylon-wool fiber (NWF) using the scanning electron microscope and biochemical analysis of elution fractions. We have determined that mechanical removal of neutrophils from nylon-wool fiber disrupts neutrophils adherent to nylon-wool fiber and au... | 508,935 | [
-0.003400065,
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0.3581793,
0.3230835,
0.3657871,
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... |
Central nervous system relapse in malignant lymphomas: risk factors and implications for prophylaxis. | The records of 292 patients with malignant lymphoma other than Hodgkin's disease, registered in our protocols from 1967 to 1977, were reviewed to identify those with central nervous system (CNS) involvement. Thirty-one patients were encountered with this complication, an incidence of 11%. Patients with a diffuse histol... | 508,936 | [
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0.1033094,
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... |
[The effect on gas mixing of a He-O2 mixture in chronic obstructive lung diseases (author's transl)]. | In order to estimate the role played by gaseous diffusion in the mixing disorders of chronic obstructive lung disease (COLD), the effect of breathing a gas mixture lighter than air has been studied. Twenty four patients with severe airflow obstruction have been tested in the following way: in a random order they breath... | 508,974 | [
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0.1321404,
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0.2801743,
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0.02413778,
-0.0... |
Indoor spread of respiratory infection by recirculation of air. | Stimulated by an outbreak of measles that was spread throughout a school by the ventilating system, we looked into the possibility of preventing this hazard in air conditioned buildings. The amount of air recirculated by air conditioning systems increases as the temperature difference between indoor and outdoor air inc... | 508,976 | [
-0.3296279,
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0.2638312,
0.35207,
0.0805959,
... |
Dyspnea. | Dyspnea is the medical term for the patient's or subject's complaint of shortness of breath. It encompasses the respiratory discomfort experienced in many different diease states as well as the shortness of breath felt by a normal subject during or after strenuous exercise. Several parameters which have been shown to c... | 508,981 | [
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0.2404688,
-0.06041822,
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0.2596957,
-0.1240301... |
A method for the study of therapeutic factors in group psychotherapy. | A method is described for the study of therapeutic factors in group therapy in which patients and their therapists prepare brief reports at regular intervals about those events in treatment which they regard as important; these reports are then assigned by independent judges to a classification of therapeutic factors w... | 509,006 | [
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0.1887061,
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0.4884869,
0.004777774,
0.08117963,
-0.14148... |
The validity of addict notifications. | Two representative samples of males first notified as addicts during 1969, one by hospitals and the other by penal establishments, were followed up for five years. It was found that 95 per cent of the hospital sample, but only 30 per cent of the penal sample, were addicted to opiates at some time during this follow-up,... | 509,007 | [
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0.4718962,
0.1255422,
0.1094368,
0.107463,
0.06537962,
0.03640186,
0.3801... |
Torticollis caused by an infratentorial tumour: three cases. | Three cases with torticollis caused by an infratentorial tumour are presented. A father and his son both had a Lindau tumour, and another patient had an ependymoma. It is stressed that torticollis may be the predominant or only sign of an infratentorial tumour, and that torticollis should always be suspected to have an... | 509,012 | [
0.003362458,
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... |
Myelographic features of the normal sacral sac. | One hundred and sixty normal sacral sacs at myelography have been studied and the results analysed statistically. The features which may have clinical relevance are discussed. | 509,023 | [
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0.02934434,
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... |
Real-time ultrasound. A new method for studying gall-bladder kinetics. | Real-time ultrasound has been found to be a satisfactory method for studying changes in gall-bladder size. It is superior to many other methods since it is non-invasive, harmless, and does not rely on the metabolism of a contrast agent. We have also found it easy to identify and compensate for changes in the gall-bladd... | 509,026 | [
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... |
Cardio-inhibitory mechanism in the gigantocellular reticular nucleus of the medulla oblongata. | A cardio-inhibitory mechanism was localized in the ventral part of the medullary gigantocellular reticular nucleus (GRN) in chloralose--urethane anesthetized cats. Stimulation of this mechanism produced an average 58.9% reduction of the heart rate (calculated from 55 responsive points having more than 40% reduction) as... | 509,206 | [
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0.2903676,
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0.2486149,
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Cerebral metabolic and circulatory changes in the rat during sustained seizures induced by DL-homocysteine. | Sustained, generalized seizure activity was induced in anaesthetized (70% N2O), paralyzed and artifically ventilated rats by i.p. DL-homocysteine thiolactone in a dose of 11 mmol/kg. Epileptic discharges in the EEG were accompanied by marked perturbation of tissue metabolites. There was a fall in phosphocreatine concen... | 509,226 | [
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0.1906851,
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0.1832556,
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0.3598212,
0.2054447,
-... |
The role of fibrosis in the small airways in centrilobular emphysema. | Small non-respiratory bronchi of lungs of patients suffering from slight and severe centrilobular emphysema of city dwellers and from focal dust emphysema, has been studied, by means of serial sections assessing the importance of the connective tissue proliferation in relation to the cross-sectional morphology of the b... | 509,316 | [
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Cardiovascular signs of acute hypoxaemia and hypercarbia during enflurane and halothane anaesthesia in man. | We investigated the impact of enflurane and halothane (1.1 MAC) on heart rate and blood pressure responses to experimental hypoxaemia (PETo2 6.0 kPa [45 torr]) and small increments in PCO2 (1.3--1.6 KPa [10--12 torr]). The results reaffirm that circulatory signs of mild hypercarbia are vitually abolished by these anaes... | 509,344 | [
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0.... |
Action of galactose oxidase on galactolipids. | Exposure of galactose-containing glycosphingolipids and certain glycoproteins to galactose oxidase followed by treatment with sodium borotritide has been used to label specifically the terminal galactose and N-acetylgalactosamine moieties of these glycoconjugates. This labelling procedure was shown to be ineffective wi... | 509,355 | [
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Transmission of Oesophagostomum species in swine on pasture in the Maritime provinces. | Field experiments carried out in the Maritime area of Canada failed to demonstrate overwinter survival of porcine nodular worms, Oesophagostomum quadrispinulatum and O. dentatum. Pastures were contaminated by carrier animals with subsequent transmission of infection to susceptible pigs. One approach to control of oesop... | 509,377 | [
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0.5120714,
0.01914239... |
tRNA breakdown products as markers for cancer. | Seven breakdown products of tRNA were quantitated by high pressure liquid chromatography in urine and were related to the creatinine content. In the urine of 26 of 27 patients with 13 different malignancies, there was an elevation of one or more of these "markers." The levels of excretion vary approximately with the st... | 509,391 | [
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Urinary metabolite of 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene with an intact diazoamino structure. | The tumour-inhibiting substance 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene is metabolised in rats to the corresponding substituted 1-O-(triazenyl-methyl) glucuronic acid. The urinary metabolite was purified by ion exchange chromatography and gel filtration, and isolated from the enriched fractions by freeze-drying.... | 509,404 | [
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Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene. | Addition of 4 ppm Se to the drinking water of male albino rats fed diets containing 0.03% 2-acetylaminofluorene (AAF) provided protection against hepatic damage and also resulted in at least 50% reduction in liver tumor incidence. An in vitro assay system utilizing microsomes from Se supplemented or non-supplemented 3-... | 509,411 | [
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Alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine by human liver microsomes. | The environmental carcinogens N-nitrosopyrrolidine (NPYR) and N'-nitrosonornicotine (NNN) were incubated with human liver microsomes to test for the presence of enzymes catalyzing alpha-hydroxylation, which is likely to be an activation mechanism for these compounds. Both nitrosamines underwent alpha-hydroxylation; rat... | 509,417 | [
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0.03981923,
... |
Precocene-induced necrosis and haemocyte-mediated breakdown of corpora allata in nymps of the locust Locusta migratoria. | Light and electron microscopic studies, including the use of the vital dyes trypan blue and acridine orange, indicate that the topical application of precocene II rapidly triggers degenerative processes in the corpora allata (CA) leading within a few days to the virtual disappearance of the parenchymal cells of these g... | 509,510 | [
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Increased prostaglandin F2 alpha and E2 production in late passage WI38 diploid fibroblasts. | The prostaglandin (PG) F2alpha and E2 concentrations in the culture medium of WI38 cells were determined at various passage levels. It was found that late passage cells produce significantly higher amounts of both PG F2alpha and PG E2. | 509,542 | [
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A comparison of nuclear and nucleolar matrix proteins from rat liver. | The comparison of the gel electrophoresis patterns of nuclear and nucleolar matrix proteins reveals marked differences between these structures. The nucleolar matrix contains 5 prominent protein bands ( mol.wt.: 8.2; 7.0; 5.6; 4.0 and 3.0 x 10 4 ) which are not found in nuclei. It is suggested that the nucleolar matrix... | 509,546 | [
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0.01630826,
0.01206... |
Relationship between DNA alkylation and specific-locus mutation induction by N-methyl- and N-ethyl-N-nitrosourea in cultured Chinese hamster ovary cells (CHO/HGPRT system). | Chinese hamster ovary (CHO) cells in culture were utilized to determine the cytotoxicity, specific-locus mutation induction, and DNA alkylation which result from treatment of the cells with a range of concentrations of N-methyl-N-nitrosourea (MNU) or N-ethyl-N-nitrosourea (ENU). With [3H]MNU over the concentration rang... | 509,687 | [
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Senescent changes in rodent hepatic epoxide metabolism. | Age-related alterations in epoxide metabolism were examined in subcellular fractions of liver from 3-, 12- and over 24-month-old male rats and mice. Using styrene oxide as the substrate, glutathione-S-transferase activity remained unchanged while the activity of epoxide hydrase increased with age in both species. The m... | 509,688 | [
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Sister chromatid exchanges induced in cultured mammalian cells by chromate. | Chromate compounds induced sister chromatoid exchanges (SCEs) and chromosome aberrations in cultured mammalian cells. Similar increases in SCE frequency were observed in human fibroblasts exposed to the compounds K2Cr2O7 and K2CrO4. Marked increases in SCE frequency in cells exposed to chromate for a 48-h period were d... | 509,691 | [
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0.008591356,
... |
A comparative study on estradiol receptor assays in human breast cancer tissue. | Standard dextran-coated charcoal assays for measuring the estrogen receptor content in human breast cancer tissue are compared. A single-point assay, using the estrogen antagonist nafoxidine as competitive inhibitor, showed good qualitative agreement with a three-point Scatchard plot assay, using radio-inert estrogen t... | 509,736 | [
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Scintiphotographic evaluation of LeVeen peritoneo-venous shunt patency using intraperitoneal Tc-99m-MAA. | A simple method is described for assessing the patency of LeVeen peritoneo-venous shunts. Following the intraperitoneal injection of 5 mCi of Tc-99m-MAA pulmonary radioactivity is monitored using a gamma scintillation camera. Lung visualization indicates shunt patency, while lack of lung uptake implies shunt obstructio... | 509,843 | [
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0.09115303,
0.102... |
Displacement of the abdominal aorta by a pseudocyst of the pancreas. | Cystic lesions are generally thought not to displace the abdominal aorta. A case involving a large cystic mass near the pancreas which was proven to be a pancreatic pseudocyst is presented, with a dynamic nuclear angiogram and a CT scan of the abdomen showing displacement of the aorta. | 509,848 | [
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Water soluble radiculography in the erect posture: a clinico-radiological study. | A technique for water-soluble radiculography is described involving radiography in the standing and stooping positions. Seventy-eight radiculograms have been reviewed and correlated with clinical and operative findings. Thirty patients had an anterior thecal deformity demonstrated on radiographs exposed in the standing... | 509,868 | [
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Laetrile and pregnancy. | Pregnancy in a woman who took laetrile as daily intramuscular injections during the last trimester resulted in a live, term infant. No laboratory or clinical evidence of elevated cyanide or thiocyanate, a pricipal metabolite, could be detected. Neurological evidence of chronic cyanide exposure may not be recognizable i... | 509,883 | [
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... |
Crisis intervention in the court room: the case of the night prosecutor. | Often the cases seen in a municipal court or a mental health center's crisis department are identical. The concepts used to describe these common cases and the resultant agency actions taken differ drastically between the legal and mental health arenas. This paper presents a working model that combines mental health an... | 509,920 | [
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Nickel concentration of blood, urine and sweat after oral administration. | Healthy volunteers without nickel hypersensitivity were given 5.6 mg nickel orally. The nickel concentration was assayed in urine, serum and sauna-provocated sweat from hands and trunk before and after nickel ingestion. The nickel concentration in serum increased in all subjects, and in most cases in urine, but not dec... | 509,933 | [
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Termination of pregnancy in rabbit and mouse by Trichosanthin. | The effects of a single intraperitoneal injection of Trichosanthin in 6-, 10-, 17- or 22-day pregnant rabbit (2 mg/rabbit) or in 11-day pregnant mouse (50 micrograms/mouse) were studied. Trichosanthin induced abortion in 100% of the 17- or 22-day pregnant rabbits within 48-72 hours and decreased circulating progesteron... | 509,962 | [
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-... |
External ventricular drainage. A technical note. | The disadvantages of external ventricular drainage are the threat of sepsis and the nuisance of dislodging a precarious system in routine care. The experience of the authors with nearly 200 cases using a long ventricular catheter demonstrates that a subgaleal tunnel can be easily made for the ventricular catheter using... | 509,970 | [
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0.022291... |
Psoralen and sunlight for psoriasis in the Southwest. | The treatment of psoriasis with psoralen and direct sunlight has been reported as successful but unpredictable because of its dependence on prevailing weather conditions which are subject to marked daily and seasonal variations. A study carried out in a locale nearly ideal because of its reliable year-round sunshine pr... | 509,980 | [
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Genome structure and divergence of nucleotide sequences in echinodermata. | The arrangement of repetitive and single-copy DNA sequences has been studied in DNA of some species of Echinodermata--sea urchin, starfishes and sea-cucumber. Comparison of the reassociation kinetics of short and long DNA fragments indicates that the pattern of DNA sequence organization of all these species is similar ... | 510,077 | [
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-0.1... |
Chromomeres and puffing in experimentally induced polytene chromosomes of Calliphora erythrocephala. | In the most advanced types of meroistic ovaries the synthesis of RNA for the growing oocyte in each follicle is taken over by nurse cells, i.e., sister cells of the definite egg cell. In calliphora, the highly polyploid nurse cells (NC) develop a polytene karyotype under conditions of strict brother-sister inbreeding a... | 510,083 | [
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Role of defunctionalized bowel in jejunoileal bypass-induced liver disease in rats. | The pathogenesis of jejunoileal bypass-induced liver disease was investigated in the rat model. Male Sprague-Dawley rats were subjected to 90% jejunoileal bypass and compared to rats having undergone 90% jejunoileal resection, to ad libitum and pair-fed controls and to weight-matched (underfed) controls. After 8 weeks ... | 510,091 | [
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... |
Reuse of disposable syringe-needle units in the diabetic patient. | A comparison was made between reuse of plastic disposable needle-syringe units and glass syringes with daily new needles in diabetic patients who take daily insulin injections. Parameters studied were incidence of infection, clarity of syringe readings, ability to use syringe, and sharpness of needle. The plastic dispo... | 510,141 | [
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0.04758091,
0.1313946,
-0.005673802,
0.1476842,
0.2276143,
-0.4224156,
-0.3867377,
-0.2281351,
0.125181,
-0.212832,
-0.07705942,
0.01605103,
-0.1603213,
0.001937452,
0.1369046,
-0.1376696,
0.1449243... |
Parental attitudes toward children with a chronic medical disorder: special reference to diabetes mellitus. | Children who suffer from chronic medical disorders requiring continuous therapy create threatening situations for parents, which are often acute at diagnosis and may continue over the years. Many parental reactions and consequent emotional interactions with the children are common to all medical handicaps, but also var... | 510,143 | [
-0.3025945,
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-0.16842,
0.01354433,
0.2115782,
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0.08951649,
0.1049945,
0.1622995,
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0.1875316,
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-0.2767113,
0.004500019... |
[Minimal effective dose of bacampicillin in urinary tract infections (author's transl)]. | 66 patients from a nephrological out-patient clinic in whom an ampicillin-sensitive pathogen had been demonstrated after suprapubic puncture, were divided into 3 randomised groups. The first group received 10, the second 20 and the third 30 tablets of 800 mg bacampicillin each. Tablets were given t.i.d. Due to randomis... | 510,196 | [
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-0.05508688,
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0.1265797,
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0.428958,
0.3526537,
0.02155919,
0.1134515,
... |
[Pituitary growth hormone content in swine]. | The growth hormone content in the adenohypophysis in different lines of swine was determined by radioimmunoassay. The result indicates that animals of an obese type (Vietnamesisches Hángebauchschwein) show a significantly lower growth hormone content (154.9 +/- 34.3 microgram gh/mg protein) than animals of a lean type ... | 510,219 | [
0.1386053,
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0.3182634,
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0.1851245,
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0.3861778,
0.2886733,
0.1177179,
0.5159476,
0.03644503,
-0.3864943,
-0.... |
Household surface lead dust: its accumulation in vacant homes. | House dust has been suspected as a source of lead in the exposure of children, particularly those whose blood lead levels are in the moderately elevated range. The means by which household surface lead accumulates is at present not clear. By towel wipe sampling, 24 vacant houses in urban Rochester and Buffalo, New York... | 510,237 | [
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0.1851409,
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0.02786819,
0.004212943,
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0.1235093,
0.07289962,
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0.2006329,
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0.1542021,
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0.08542525,
0.5832222,
-0.3164239,
0.008355021,
0.4817715,
-0.05003476,... |
Age and sensitivity to lead toxicity: a review. | During the past 20 years considerable attention has been focused on the epidemiologic features of childhood lead poisoning in the United States. Large numbers of children with symptomatic intoxication, as well as those with incipient symptoms, were commonplace a decade ago for physicians working in inner-city hospitals... | 510,238 | [
-0.2161378,
-0.1211841,
-0.2485447,
0.1460411,
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0.1133313,
0.04443315,
0.1287425,
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0.1190912,
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0.2933197,
0.1411738,
0.2449323,
0.1728642,
0.5931761,
-0.1152198,
-0.1... |
Effects of environmental oxidant stressors on individuals with a G-6-PD deficiency with particular reference to an animal model. | Individuals with a G-6-PD deficiency have long been known to be at increased risk to experience acute hemolysis following exposure to elevated levels of certain oxidant drugs and industrial chemicals. However, the recognition of enhanced susceptibility to environmental (or ambient) pollutants has generally not been con... | 510,241 | [
-0.387593,
-0.3047442,
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-0.1690672,
0.1940892,
0.09942305,
0.3101756,
0.0002517861,
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-0.4328673,
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0.4272792,
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0.1548798,
-0.04250875,
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-0.4583977,
0.3154567,
0.2364435,
0.2157517,
-0.0993772,
0.2955798,
-0.09531654,... |
Nutritional influences on metal toxicity: cadmium as a model toxic element. | The nutrient quality of the diet has been shown repeatedly to be a significant factor in modifying the response of man and animals to toxic element exposure. Deficiencies of several essential nutrients have been shown to exacerbate the effects of cadmium and supplements of such nutrients have been shown to ameliorate t... | 510,248 | [
-0.3326618,
-0.106548,
0.01654512,
0.009798985,
-0.04165302,
-0.1371313,
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0.03223576,
0.1294649,
0.0272508,
-0.01489634,
0.1864087,
0.1132162,
0.08836383,
-0.6154807,
-0.08022314,
-0.3639665,
-0.02471036,
-0.1666488,
0.1858381,
-0.1724667,
0.3770936,
-0.02912964... |
Influence of Mg2+ ions on the activity measurement of isoenzymes of alkaline phosphatase. | The activity of alkaline phosphatase isoenzymes from liver, bone and small intestine is differently influenced by Mg2+. The stimulation of isoenzymes from liver and bone is higher by Mg2+ ions than in the case of isoenzymes from small intestine. An obligatory preincubation of the serum sample in a buffer-Mg2+ mixture i... | 510,276 | [
-0.2675675,
-0.2221068,
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0.0447963,
-0.09367751,
-0.1666349,
-0.3174729,
0.380886,
-0.1921556,
-0.1892937,
0.1702171,
-0.1190318,
0.05159257,
-0.02285502,
-0.6743413,
0.03127363,
-0.3234191,
-0.0716937,
-0.03384521,
0.5016083,
0.4254745,
-0.02730869,
0.08822378... |
The energy metabolism of the leucocyte. X. Kinetics of oxygen consumption during phagocytosis by polymorphonuclear leucocytes. A photometric method. | A simple micromethod for quantitative assay of the oxygen consumption by phagocytosing human neutrophils had been described. The continuous assay shows a lag time between the addition of zymosan and the maximal rate of oxygen uptake, which is a measure of the serum opsonic activity. Several factors can alter the oxygen... | 510,277 | [
0.1321307,
0.0006636376,
-0.3055822,
0.1434131,
0.1725462,
-0.3431097,
-0.324721,
0.07424826,
-0.09884821,
-0.1620502,
-0.1449001,
-0.1488555,
-0.02757863,
0.1698693,
-0.4586593,
-0.2614387,
-0.4779642,
0.1264775,
-0.1120953,
0.1757539,
0.4274708,
0.1220168,
0.05538912,
... |
Cholesterol ester:lysolecithin transacylation in the aorta. | Acyl transfer from cholesteryl oleate on lysolecithin to release cholesterol and form lecithin has been demonstrated in the aortic wall. Mechanism of the enzyme-catalyzed transacylation is considered in relation to the arterial cholesterol ester hydrolase. | 510,279 | [
-0.2194936,
0.02954643,
-0.3614537,
0.03909583,
0.01097509,
-0.2067106,
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0.08507154,
0.1083879,
0.1187017,
0.1804692,
0.07865395,
0.1849679,
0.004816228,
-0.4918347,
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-0.7322736,
-0.001969393,
-0.2288662,
0.3357582,
-0.01052951,
0.3406809,
-0.065323... |
[Approaches to reduce the retroaction of long-term monitoring of bioelectric events in ergonomic field studies (author's transl)]. | When monitoring bioelectric signals the surface electrodes can cause a retroaction on the subject thereby introducing an error of measurement. There are two types of retroaction: physical and psycho-physiological. A physical retroaction due to the hydration process of the skin occurs if 'wet' electrodes are used for th... | 510,281 | [
0.02031987,
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0.06179629,
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0.1445059,
0.1523333,
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0.06363875,
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0.2500412,
0.1186616,
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-0.4286681,
-0.1319115,
-0.02481756,
0.1315324,
0.1499255,
0.1654813,
-0.07810109,... |
Urinary excretion of oligosaccharides induced by galactose given orally or intravenously. | The effect of oral administration of galactose, lactose, and sucrose and intravenous injection of galactose on the urinary excretion of blood-group-active oligosaccharides has been studied. Galactose given either as the free sugar, a glycoside (lactose) or a constituent of normal diet was an absolute requirement for th... | 510,288 | [
0.02348536,
-0.1005625,
-0.2460944,
0.048696,
0.2732618,
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0.0589969,
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0.08807129,
0.003040255,
0.2710702,
-0.08620104,
-0.1648303,
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-0.06714315,
-0.3500775,
-0.02540328,
0.1477881,
-0.140413,
0.2312931,
0.5901948,
-0.1057586,
... |
Elucidation on sudden death in children with the mucocutaneous lymph node syndrome. | Atrial pacing was carried out in six children aged one year to eleven years with the mucocutaneous lymph node syndrome (MCLS) during cardiac catheterization. The cardiac index (CI) was measured before pacing and at pacing rates of 150 and 180/min. The CI increased in cases which did not show any pathological findings o... | 510,319 | [
-0.2143576,
-0.4494587,
-0.07990684,
0.06174356,
0.1056628,
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0.1359378,
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0.3118864,
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-0.4168899,
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-0.3397988,
0.02089198,
-0.07749292,
0.08571951,
0.6404643,
-0.06526896,
-0.16271... |
Mechanisms of bronchoconstriction and of thrombocytopenia induced by collagen in the guinea pig. | Collagen injected to guinea pigs i.v. increased the pulmonary resistance to inflation (bronchoconstriction) and induced thrombocytopenia. Immune platelet depletion protected against the effects of collagen, and has been shown not to prevent bronchoconstriction induced by the prostaglandin/thromboxane A2 precursor arach... | 510,359 | [
0.2391628,
-0.2099841,
-0.2159493,
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-0.2399105,
0.2661681,
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0.05148628,
0.1496271,
0.2849383,
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-0.1911507,
0.1737103,
0.2377934,
0.2770123,
0.1449744,
-0.09618213,
-0.02169258... |
Autoanalgesia: acquisition, blockade and relationship to opiate binding. | Acquisition of autoanalgesia (behaviorally activated antinociception) was assessed across 7 consecutive days by shocking rats 10 sec after the determination of their tail-flick latencies. Thus the effect of conditioned fear on antinociception was being investigated, since each shock preceded the subsequent tail-flick t... | 510,378 | [
0.2080031,
-0.005641836,
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0.1045276,
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0.2237312,
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0.008326001,
0.1986876,
0.1960686,
-0.02413348,
0.05116878,
-0.1217705,... |
Anticholinergic behavioral effect of phencyclidine. | Phencyclidine (PCP) impaired spatial alternation performance in rats. This effects was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration... | 510,389 | [
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0.215199,
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0.0858833,
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0.0009021704,
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0.08728115,
0.5111629,
0.07143949,
0.473705,
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-0.9825646,
0.170377,
-0.02160101,
-0.01288381,
-0.1743644,
0.08162311,
0.3021654,... |
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