title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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On the inhibition of human leukocyte elastase by trifluoroacetyl tripeptides. | The recently reported Ki values for human leukocyte elastase and a series of trifluoroacetylated peptides are erroneous because the enzyme preparation was contaminated by a small amount of porcine pancreatic elastase. The correct Ki values are much higher. However, trifluoroacetylated peptides are still much more poten... | 565,771 | [
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Meiotic maturation of mouse oocytes in vitro: protein synthesis in nucleate and anucleate oocyte fragments. | Nucleate and anucleate fragments of mouse oocytes have been isolated following treatment of fully grown oocytes with cytochalasin B. The nucleate oocyte fragments resume meiosis in vitro, progressing from dictyate of the first meiotic prophase to metaphase II ('meiotic maturation'), and exhibit all of the changes in pr... | 565,788 | [
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Common features of coated vesicles from dissimilar tissues: composition and structure. | Coated vesicles were purified and characterized from porcine brain and chicken oocyte. Electrophoresis on sodium dodecylsulphate (SDS) gels showed that coated vesicles from either source have three major proteins in common with apparent molecular weights of 180000, 120000, and 55000 Daltons. Negatively stained specimen... | 565,792 | [
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Cefamandole---a review of chemistry and microbiology. | The discovery of cephalosporin C and its conversion to 7-aminocephalosporanic acid (7-ACA) are reviewed. The syntheses of cefamandole and three other injectable cephalosporins from 7-ACA are described, and the antibiotic properties of the four drugs are compared. The microbiological potency of cefamandole is comparable... | 565,798 | [
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Hormone-dependent mammary tumors in strain GR/A mice. IV. Origin and progression. | Two types of hormone-dependent mammary tumors that occur in strain GR/A mice, i.e., those that appear during pregnancy [pregnancy-dependent mammary tumors (PrDT)] and those induced by treatment with progesterone (P) and estrogen (E) [P + E-dependent mammary tumors (P + E-DT)], were compared in terms of serial transplan... | 565,819 | [
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Strokes and ulcerative colitis. | One adolescent and two young adults had ulcerative colitis and cerebral thrombosis. All survived with neurologic deficit. These patients had no other predisposing factor for cerebrovascular disease. Systemic arterial and venous thromboembolic complications occur often in ulcerative colitis, but stroke is uncommon. Abno... | 565,888 | [
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[Comparison of ct and angiographical findings of tumors of the posterior cranial fossa (author's transl)]. | Variations of tumors of the posterior cranial fossa in CT are discussed especially concerning their anatomical and pathological picture and compared with angiographical findings. The differential diagnosis of cysts and cystic tumors of the posterior cranial fossa is outlined as most important progress of computerized a... | 565,948 | [
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[Experimental informational neuroses in dogs as sequelae of overloading short-term memory]. | In conditions of overloaded function of short-term memory, studied by the method of delayed reactions, with a prolonged deficit of time allotted for realization of the function, the animals exhibit substantial disturbances of higher nervous activity which by their etiological character belong to the group of informatio... | 565,996 | [
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[The menstrual cycle in adolescents]. | Data concerning onset and development of menstrual function were received by questionnaire from 740 girls attending the 10th classes of all schools in the city and the county of Jena. Menarche occurred at a mean age of 13 years and 3 months. with a standard deviation of 9.6 months. 6 girls (0,8%) had not yet observed t... | 566,004 | [
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Diazepam and succinylcholine-induced muscle pains. | Postoperative muscle pains occurred in 16% of 25 patients given 10 mg diazepam IV 5 minutes prior to succinylcholine. Postoperative muscle pains occurred in 60% of 25 patients not given diazepam before succinylcholine. The difference is statistically significant. Diazepam reduced the severity and duration of postoperat... | 566,045 | [
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Scanning electron microscopy of the cephalic structures of Pneumospiruridae. (Thelazioidea - Nematoda). Revision of the family. | In a study with the scanning electron microscope (SEM) five different types of cephalic structure were found in five species of Pneumospiruridae recorded in Israel. The description, in the literature, of a sixth type, based on a study with the light microscope, was also considered in evaluating the results. By comparin... | 566,076 | [
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Enumeration and isolation of anaerobic microbiota of piggery wastes. | Media for enumeration of the microbiota of anaerobically stored piggery wastes were tested. Highest colony counts were obtained with 80 to 100% farm slurry supernatant included in the anaerobic roll tube media. Colony counts with these media numbered 2 X 10(9) to 12 X 10(9)/g (wet weight), which represents about 20% of... | 566,081 | [
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Electrical safety for the veterinary surgeon. | In human medicine, protection of the patient has demanded stringent safety precautions that have not been applied in the veterinary field. There is a hazard to the operator from the increasing use of electrical equipment in veterinary medicine, often in an environment where conducting floors and other items can carry f... | 566,096 | [
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The active site of rabbit muscle pyruvate kinase. Evidence for a site common to the oxalacetate decarboxylase and pyruvate kinase reactions. | Rabbit muscle pyruvate kinase has been shown to catalyze the decarboxylation of oxalacetate (Creighton, D.J. and Rose, I.A. (1976) J. Biol. Chem. 251, 61). Noncovalent and covalent modifiers of the enzyme have been used to assess whether the decarboxylase and kinase reactions take place at a common site. Phosphoenol-al... | 566,117 | [
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A simple, one-step chromatographic procedure for the purification of lysozyme. | A rapid method for the purification of lysozyme (mucopeptide N-acetyl-muramoylhydrolase, EC 3.2.1.17) from hen egg-white has been devised. It was that gel filtration chromatography on agarose columns can be used selectively to purify lysozyme, due to the fact that this protein interacts with the agarose matrix and elut... | 566,118 | [
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Oogenesis in Acerentomon gallicum Jonescu (Protura). An ultrastructural analysis of the early previtellogenic stages. | At the onset of previtellogenesis, the oocytes of Acerentomon gallicum begin to grow and increase their content of organelles. The nuage material in the oocytes at first increases in amount, then declines gradually to disappear completely from oocytes that have attained 50 micrometer in diameter. During the growth peri... | 566,158 | [
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Studies on the ultrastructure of the rotifer Habrotrocha rosa Donner (Aschelminthes). The alimentary system. | The alimentary system of Habrotrocha rosa is composed of the alimentary channel, five digestive glands and another gland which is in close relation to the intestinal syncytium. After the present investigation, the alimentary channel can be divided into sections which clearly differ from each other, these are: oral cavi... | 566,160 | [
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The nucleotide sequence of oocyte 5S DNA in Xenopus laevis. II. The GC-rich region. | The primary sequence of the GC-rich half of the repeating unit in X. laevis 5S DNA has been determined in both a single plasmid-cloned repeating unit and in the total population of repeatig units. The GC-rich half of the repeating unit contains a single long duplication of 174 nucleotides. The duplicated segment commen... | 566,164 | [
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Heritability in syntactic development: a critique of Munsinger and Douglass. | Munsinger and Douglass (Child Development, 1976, 47, 40-50) used the Assessment of Children's Language Comprehension and the Northwestern Syntax Screening Test as measures of syntactic ability to investigate the heritability factor in language acquisition. By comparing the concordance of scores of twins and siblings, t... | 566,192 | [
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Intranigral kainic acid: evidence for nigral non-dopaminergic neurons controlling posture and behavior in a manner opposite to the dopaminergic ones. | The unilateral, intranigral administration of kainic acid (k.a.) produced a syndrome characterized by early sequelae of contra- and ipsilateral circling and by a chronic contralateral turning associated with moderate loss of neurons in the pars reticulata. The acute contralateral circling seems to be related to dopamin... | 566,206 | [
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Unreliability of chromogenic substrates for assay of the clotting activity of thrombin. | The rapid loss in clotting activity of commercially available thrombins during storage is not reflected by their activity as measured by synthetic chromogenic substrates. It is suggested that conformational changes occurring during storage can affect the binding sites of thrombin for fibrinogen, whereas small synthetic... | 566,247 | [
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Stress-induced depression model in female rats--biochemical and histochemical investigation of brain monoamines. | Forced running stress induced a prolonged inactive state with the abolition of hormone-dependent cyclic behavior in some female rats which had already recovered from physical exhaustion. The state could be regarded as a "depression model" in these animals. In the biochemical study, norepinephrine in the hypothalamus wa... | 566,250 | [
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Effects of ovariectomy and estradiol replacement therapy upon the sexual and aggressive behavior of the greater galago (Galago crassicaudatus crassicaudatus). | The effects of ovariectomy and estradiol treatment upon sexual and aggressive behavior were studied in a prosimian primate, the greater galago. Ovariectomized galagos were sexually unreceptive and frequently aggressive, but retained their sexual attractiveness to males. When females were treated with estradiol monobenz... | 566,251 | [
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Control of glycolysis and the pentose phosphate shunt in transformed 3T3 cultures rendered permeable by ATP. | Exogenous ATP has been shown earlier to activate a permeability change in transformed 3T3 cultures leading to massive efflux of the acid-soluble pools. This leads to reduction of the basal rate of glycolysis to a very low level so that glycolysis becomes almost totally dependent on the addition to the medium of glucose... | 566,277 | [
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Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus. | Lymphocytic choriomeningitis virus strain WE multiplied in cultivated peritoneal macrophages from unstimulated NMRI mice. As revealed by immunofluorescence technique, most cells participated in the infectious process. They were not, however, functionally altered. Morphologically, infected cells contained more cytoplasm... | 566,306 | [
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[Molecular ageing in bovine plasma albumin I. Exposure of disulfide bonds in the N-B transition (author's transl)]. | An accessibility of the disulfide bonds of defatted SH-blocked bovine plasma albumin (BPA) to reduction by dithiothreitol was studied at 4 degree C. Upon reduction SH-blocked BPA acquired one SH per mole in the pH range from 4.0 to 6.0. Above pH 6.5 (the pH range of the N-B transition) an increasing number of the disul... | 566,322 | [
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Complications of permanent bladder catheter drainage in spinal cord injury patients. | We reviewed the effect of permanent bladder catheter drainage on the course of 59 long-term spinal cord injury patients. Current renal function, findings on excretory urography and major renal, bladder, genital and urethral complications were tabulated. Although all long-term spinal cord injury patients had severe rena... | 566,331 | [
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The drug laws. Are they effective and safe? | The laws controlling narcotic and other psychoactive drugs are viewed as one of three major forms of treatment designed to deal with the drug problem: laws, prevention, and rehabilitation. All three modalities should be evaluated for effectiveness and safety in the same way we would evaluate surgical or pharmacologic t... | 566,335 | [
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[Technique of the introduction of duodenal sounds in children (author's transl)]. | Duodenal Sounds, provided they are sufficiently rigid, can be introduced actively with simultaneous x-ray control. Good sedation promotes rapid passage; further important aids are: appropriate positioning of the patient, instillation of air, and palpation. In recent years, intravenous administration of diazepam and met... | 566,348 | [
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Physician responsibility for the cost of unnecessary medical services. | Most diagnostic and therapeutic services are ordered by physicians, but physicians practicing under fee-for-service conditions have few incentives to contain the costs of medical care. Without such incentives, effective cost control through mechanisms such as Professional Standards Review Organizations have been disapp... | 566,381 | [
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[Glutamic acid gamma-ethyl ester in high doses in the treatment of high blood ammonia levels in severe hepatic failure]. | The AA. administered i.v. large doses of gamma-ethylester of glutamic acid to 22 patients affected with severe liver failure associated to mental and neuromuscolar abnormalities as tremors, confusion, restlesness which have been duly recorded for the purpose of this evaluation. The average daily dose was 36.3 gm and th... | 566,393 | [
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Maternal serum estrogen and progesterone concentrations preceding normal labor. | Simultaneous measurement of serum concentrations of estrone (E1), estradiol (E2), estriol (E3), and progesterone were carried out in multiple serial blood samples obtained during the last 3-10 weeks of pregnancy, labor, and the immediate postpartum period in 5 normal women. Estrogen and progesterone levels showed a sma... | 566,408 | [
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Biochemical evidence for keratinization by mouse epidermal cells in culture. | More than 70 percent of the urea-extractable proteins from mouse stratum corneum or from differentiated cells of mouse epidermis grown in culture are two proteins of molecular weight 68,000 (keratin I) and 60,000 (kerae are two proteins of molecular weight 68,000 (keratin 1) and 60,000 (keratin 2), which are present in... | 566,466 | [
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Rabies: decimation of a wolf pack in artic Alaska. | In a pack of ten wolves, one wolf behaved atypically and fought with several packmates. This wolf was shot when it approached the author. Within 4 weeks at least six other members of the pack were dead. Rabies was confirmed in the wolf that was shot and in two others that had not decomposed. Most of the wolves infected... | 566,470 | [
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Early maternal separation increases gastric ulcer risk in rats by producing a latent thermoregulatory disturbance. | Rat pups that are separated early from their mothers, at postnatal day 15, become hypothermic when subjected to physical restraint on postnatal day 30. Restraint of separated pups also elicits an unusually high incidence of gastric erosions, as well as insomnia and an increase in quiet wakefulness. If hypothermia durin... | 566,471 | [
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[Prognostic value of neurologic findings in the newborn infant for the obstetrician]. | Prognostic value of neurologic findings of the neonate. 1. Severe cerebral symptoms of the neonate persisting during some days leads in follow-up of the survivors in 20 to 30% to severe cerebral disorders like cerebral palsy, epilepsy, physical and mental handicap, behaviour disorders. 2. Moderate cerebral disorders du... | 566,495 | [
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[Newer antimycotics. V. 3-aryl-azo-indoles (author's transl)]. | The author produced a number of 3-aryl-azo-indoles, and investigated their fungistatic efficiency in vitro. He proved, that the 3-(tolyl-azo)- and 3-(bhloro-phenyl-azo)-indoles exert a strong fungistatic effect on Trichophyton- and Epidermophyton-species, but they are inactive on other fungi-strains. Their fungistatic ... | 566,497 | [
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Release of oxytocin and substance P-like peptides from the rat posterior pituitary lobe incubated in situ after infusion of hypertonic solution into the third cerebral ventricle. | Release of oxytocin and Substance P-like peptides from the rat posterior pituitary lobe incubated in situ after infusion of hypertonic solution into the third cerebral ventricle. Acta Physiol. Pol., 1978, 29 (1): 9-16. The experiments were carried out on male rats. Under general urethane and chloralose anaesthesia the ... | 566,506 | [
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[Attempts at control of parturition in swine with dexamethasone. 1. Effect of various treatment dates in late pregnancy on onset of labor, litter and rearing performance of the sows]. | Studies were conducted with 66 gilts with synchronised ovulation, all kept in five separate experimental groups (I-V). Each of the animals received 75 mg Dexamethason (DXMS) per die over three consecutive days of pregnancy. Treatment of Groups I through V was started in this order on the 101st, 103rd, 105th, 107th or 1... | 566,535 | [
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Methylphenidate in 6-hydroxydopamine-treated developing rat pups. Effects on activity and maze performance. | In order to better devine the relationship between brain catecholaminergic mechanisms and the clinical syndrome of minimal brain dysfunction, we have developed an experimental model that has many of the features of the disorder seen in children. This model is effected by the preferential depletion of brain dopamine in ... | 566,540 | [
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The influence of rRNA and tRNA on the translation of avian globin mRNA in cell-free systems of protein synthesis. | Cell-free synthesis of globin chains in the presence of globin mRNA in an Ehrlich ascites-cell-free system is further stimulated by addition of 18- and 28-S rRNA but not of 4-S tRNA and 5-S rRNA. This stimulation can not be observed in the wheat germ cell-free system. When 125I-labelled globin mRNA was incubated in the... | 566,563 | [
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Pseudo subaortic stenosis--a catheter-induced artifact. | Three cases are reported of valvular aortic stenosis in which artifactual subvalvular chambers were recorded on pressure tracings. The pressure tracings were obtained during withdrawal of multiholed catheters from the left ventricle to the aortic root. Several recent reports have described the coexistence of valvular a... | 566,618 | [
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Hemodynamic and metabolic response after abrupt uithdrawal of long-term propranolol. | Because the mechanism of adverse reactions to abrupt withdrawal of propranolol in patients with coronary disease is an enigma, we studied the effect of cessation of propranolol on beta receptor reactivity to catecholamine stimulation. Heart rate and maximum rate of rise of left ventricular pressur (dP/dt max) during is... | 566,642 | [
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A neuropharmacological analysis of central nervous system catecholamine systems in development protein malnutrition. | Four experiments were performed to evaluate the effects of developmental protein deprivation on the behavioral response of adult rats to treatments known to affect central nervous system catecholamine systems. Results showed no group differences between protein malnourished and control animals in locomotor responsivene... | 566,687 | [
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The presence of lysosomal hyaluronidase in the rabbit iris. | Lysosomal hyaluronidase in the rabbit iris was studied by means of a sensitive assay method based on carbocyanine dye binding. The enzyme activity in the lysosomal extract was proportional to both the enzyme concentration and the incubation time. When the enzyme was heated, the enzyme activity was lost completely. When... | 566,732 | [
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Effect of sodium chloride on changing the rate-limiting step in the human placental choline acetyltransferase reaction. | The kinetic constants, Km and Vmax, for the choline acetyltransferase reaction were determined for choline and eight choline analogs under conditions of high (0.3 M) and low (approximately 0.01 M) sodium chloride. At high sodium chloride, the maximal velocities of the different substrates varied over 27-fold, while at ... | 566,752 | [
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Actin content and organization in normal and transformed cells in culture. | The amount of actin and total protein per cell in normal rat kidney (NRK) cells in culture is initially high in very low density cultures, but rapidly decreases as the cells come into contact in higher density cultures. In a viral transformant of NRK (442), the level of actin and total protein does not change significa... | 566,761 | [
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Intracellular fibres in cultured cells: analysis by scanning and transmission electron microscopy and by SDS-polyacrylamide gel electrophoresis. | The 3-dimensional structure of the fibrous cytoskeleton of 3T3 cells was examined by scanning electron microscopy of cells extracted with the non-ionic detergent Triton X-100. Detergent-extracted cells consist of the nucleus and an extensive system of fibres, the largest of which correspond to stress fibres visible by ... | 566,765 | [
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Radioimmunoassay for parathyrin. Characterization of six different antigens and antisera. | We studied six different antisera to bovine or porcine parathyrin (parathyroid hormone, PTH), produced in rabbit, guinea pigs, sheep or goat, two of which are commercially available. The antisera were characterized with regard to species specificity, affinity and their ability to identify patients with primary hyperpar... | 566,781 | [
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[A case of Ehlers-Danlos-syndrome and its zinc therapy (author's transl)]. | An 8-year-old boy presented a typical Ehlers-Danlos-syndrome. The light- and electromicroscopic findings of both skin- and muscle-biopsy cannot explain the symptoms. A deficiency of zinc and, resulting from this, a defective cohesiveness of collagenous and elastic fibres seems possible. After oral zinc treatment a sign... | 566,822 | [
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Clinical and electroencephalographic changes in progressive uremic encephalopathy. | A study of nine patients, aged 23 to 67 years, showed a remarkable sequence of EEG findings in progressive uremic encephalopathy. The initial characteristics suggested a disorder of subcortical gray matter, followed by involvement of cortical gray matter and finally white matter. The same EEG findings tended to persist... | 566,866 | [
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Epidemiology of Guillain-Barré syndrome. | From 1969 through 1972, a nationwide search for cases of Guillain-Barré syndrome (GBS) is Israel revealed 89 patients. The average annual age-adjusted incidence was 0.75 per 10(5) persons. Overall incidence of the syndrome was similar in Jewish groups of diverse ethnic backgrounds. Arabs had a lower overall incidence t... | 566,867 | [
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0.3244183,
0.04900727... |
Lergotrile in the treatment of parkinsonism. | Lergotrile mesylate, a direct-acting dopamine agonist, was administered for up to 10 months to 25 patients with Parkinson disease. Of six patients not receiving levodopa concurrently, five showed definite improvement in parkinsonian signs and symptoms. These results are the first clear indication that lergotrile is eff... | 566,868 | [
0.09031726,
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... |
The effect of levodopa, lergotrile, and bromocriptine on brain iron, manganese, and copper. | Chronic administration of a levodopa-carbidopa combination, bromocriptine, or lergotrile produced alterations of essential metal concentrations in the guinea pig caudate nucleus, frontal cortex, and cerebellar hemisphere. All long-term treatment regimens resulted in significantly increased concentrations of manganese i... | 566,875 | [
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Structuring and articulation of Rorschach inkblots in relation to alcohol consumption: a co-twin control study. | 20 male, alcohol-discordant twin pairs, aged 45 to 65 yr. were compared for ability to structure and articulate Rorschach inkblots. The Rorschach responses were evaluated by a new rating scale technique. Data were analyzed by means of one-sample t and multivariate Td2 tests. No relationship between alcohol consumption ... | 566,901 | [
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-... |
Effect of dietary oil, cholesterol, and soysterols on the lipid concentration and fatty acid composition of egg yolk, liver and serum of laying hens. | Effect of dietary lipid factors (saturated and unsaturated oil, zoo and phytosterols) on the lipid concentration and fatty acid composition of egg yolk, liver and serum of the laying hen were studied. Single Comb White Leghorn laying hens, at 30 weeks of age, were fed two basal diets containing 8.0% hydrogenated coconu... | 566,917 | [
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0.1332601,
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[Biosynthesis of amylolytic enzymes during continous cultivation of the yeast-like fungus Endomycopsis fibuliger 55-13]. | Growth of the yeast-like fungus Endomycopsis fibuliger 55-13 during continous cultivation was studied. The microorganism produced amylolytic enzymes during flow cultivation. As a result of the three-stage cultivation the productivity increased two-fold and the time of cultivation decreased by 6 hrs as compared with per... | 566,920 | [
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Effect of chronic administration and withdrawal of sodium barbitone on protein synthesis of rat brain. | After chronic administration of sodium barbitone to rats, a marked increase incorporation of [14C]-Leucine into isolated nerve endings was observed. Withdrawal of the drug resulted in a decreased incorporation with respect to values obtained with chronic ingesting animals. On the other hand chronic administration of th... | 566,928 | [
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Immunochemical studies of 5-bromodeoxyuridine. | Specific antibodies for BrdUrd and IdUrd have been produced and characterized by immunochemical studies. Studies as determined by hapten-inhibition showed a cross reactivity of less than 0.001% to thymidine, and no cross reactivity to bromodeoxycytidine, uridine or methyl cytosine. The equilibrium constant determinatio... | 566,947 | [
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Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis. | Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis. A suggestion is made to monitor blood formic acid levels and institute prompt dialysis whenever these exceed 80 mg. per 100 ml. to avert such a catastrophe. Intrave... | 566,977 | [
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... |
[Emotional stress during conditioned reflex transformation of heterogeneous instrumental reflexes]. | The factors leading to pronounced emotional stress accompanied by changes in electrical activity of hippocampus were studied in four dogs during elaboration of conditioned switching-over of heterogeneous instrumental reflexes. Objectively recorded signs of emotional stress were observed in two cases: when the animal wa... | 566,991 | [
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0.012301... |
Cardiac muscle mechanics from Doca- and aging spontaneously hypertensive rats. | Contractile properties of isolated papillary muscles from three age groups of spontaeously hypertensive rats (SHRs) were compared to those from age-matched Wistar-Kyoto rats (WKYs) to assess whether there were differences between the strains preceding and during the course of the hypertension. In all three age groups (... | 567,015 | [
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0.06513168,
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Detection of volatile sulfide-producing bacteria isolated from poultry-processing plants. | A technique using filter paper strips impregnated with 5-5'-dithiobis-nitrobenzoic acid was developed to allow the detection of bacteria (isolated from poultry-processing environs) which produced volatile sulfides (H2S, CH3SH, [CH3]2S). The technique is preferred to conventional methods in that it allows the detection ... | 567,037 | [
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0.01195866,
0.1537428,
0.5330797,
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0.0433... |
[A comparative follow up study about intellectual and motoric development of premature births at three to eight years of life (author's transl)]. | In a study involving 361 cases an average IQ for 101 was noted; the premature birth groups showed an average IQ of 99 and the control group an average IQ of 102. Statistically significant was the occurrence of mental retardation in the premature birth group when compared with the control group. In the premature birth g... | 567,159 | [
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0.4961529,
0.05629633,
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... |
Hereditary determination of several hemodynamic indices. | Investigation of the genetic determination of hemodynamic indices (the volume of circulating blood, the time of total blood circuit, the rate of lesser blood flow and the minute heart volume) is carried out in 16 mono- and 15 dizygotic twin pairs. The volume of circulating blood only was found to be highly genetically ... | 567,163 | [
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0.2813838,
0.2563162,
0.1367063,
-0.1922133... |
Oxytalan fibre formation in the cornea: a light and electron microscopical study. | Oxytalan is a fibrillar protein possessing some of the staining and ultrastructural properties of developing elastic tissue. In a study of human corneae we failed to find fibres of this type in five normal specimens but found them in each of 16 examples of keratoconus and 13 cases of post-traumatic or post-inflammatory... | 567,169 | [
0.1711273,
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0.02049142,
0.07514407,
0.03335257,
... |
Possible breakdown of volatile N-nitrosamines by enzymatic and/or microbiological agents in Swiss raw sausage. | The degradation trends of 4 added nitrosamines (NDMA, NDEA, NPIP and NPYR) in Italian type salami have been investigated. All of the added NA's were partly degraded during the ripening period of the sausages (29 days); the aliphatic ones were less stable than the heterocyclic. | 567,175 | [
-0.4351728,
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0.3306611,
0.1356763,
-0.08911882,... |
Extraction of light filth from coconut: collaborative study. | The official method for filth in coconut, 44.029, frequently produces filter papers with excessive plant debris and low hair recoveries. To overcome these deficiencies, 3 changes in the method were made: (1) the defatting step was modified to use sodium lauryl sulfate in combination with borax for better defatting; (2)... | 567,215 | [
-0.2627554,
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0.... |
Enrichment and visualization of small replication units from cultured mammalian cells. | DNA from cultured Chinese hamster cells has been fractionated to yield a population of DNA enriched for replicating molecules. Molecules containing replication structures were analyzed by electron microscopy, and replicon size was estimated. The enrichment procedure takes advantage of single-stranded regions characteri... | 567,225 | [
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0.5041085,
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0.03576589,
0.160... |
Differences in the release of melanocyte-stimulating hormone in vitro by rat pituitary glands collected at various times during the oestrous cycle. | The release of melanocyte-stimulating hormone (MSH) into the medium during incubation and the pituitary tissue content of MSH were measured separately using pituitary glands collected from rats at various stages of the oestrous cycle. The MSH was measured by a biological assay using a synthetic alpha-MSH as standard. T... | 567,239 | [
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0.02141039,
0.2728012,
0.06450631,
0.01572742,... |
Affinity of fibronectin to collagens of different genetic types and to fibrinogen. | Fibronectin, a fibroblast surface protein, was purified from human and chicken plasma and extracts of cultured chicken fibroblasts with affinity chromatography on gelatin coupled to Sepharose particles. A fibronectin-like protein was also isolated from the plasma of Torpedo fish. The collagen binding properties of fibr... | 567,240 | [
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0.581677,
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0.2666238,
-0.3632765... |
Synthesis and secretion of plasma proteins by embryonic chick hepatocytes: changing patterns during the first three days of culture. | A simple model system is described for studying synthesis of plasma proteins. The system is based on chick embryo hepatocytes in primary monolayer culture which synthesize a broad spectrum of plasma proteins and secrete them into the culture medium. The secreted proteins are stable and consist almost exclusively of pla... | 567,242 | [
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... |
Quantitative determination of the binding capacity of the sex hormone-binding globulin, using agar gel electrophoresis. | An easy, rapid and precise technique for the determination of the binding capacity of the sex hormonebinding globulin (SHBG) is described. The plasma is incubated with [3H]5 alpha-dihydrotestosterone (DHT) either alone, or together with an excess of unlabelled DHT. The SHBG-binding peaks are demonstrated by agar gel el... | 567,243 | [
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0.525042,
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... |
Activity of catechol-o-methyltransferase in brain regions and adrenal gland during the oestrus cycle. | The activity of the enzyme catechol-O-methyltransferase (COMT) during four different phases of the oestrus cycle were determined. Brain and hypothalamus had highest level of COMT activity during oestrus phase, while at pro-oestrus it was at its lowest level. COMT activity in the adrenal gland was also modified during t... | 567,245 | [
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0.2466973,
0.1824616,
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0.06755706,
-0.07931... |
Cellular and molecular toxicology of lead. III Effect of lead on heme synthesis. | The effect of lead nitrate on the biosynthesis of heme and the cellular uptake of (59)Fe was studied in an established rat liver cell line (RLC-GAI) grown in serum-free medium. Heme synthesis was shown to be increased in lead-treated cells when determined by measuring the amount of (59)Fe incorporated into the heme fra... | 567,253 | [
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0.3354368,
0.3521281,
0.6151833,
0.01443943,
... |
Diurnal variations in the motor activity of the rat: effects of inhibitors of the catecholamine synthesis. | The effects of the inhibitor of the tyrosine-hydroxylase H 44/68 and the inhibitor of the dopamine-beta-hydroxylase FLA 63 on the diurnal variations of the motor activity was studied in male Wistar rats, which were kept under standardized conditions of light and darkness (L:D = 12:12 h). The motor activity was continuo... | 567,282 | [
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0.3640234,
0.1790452,
0.3769412,
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0.... |
[Sea urchin sperm DNP. I. Chemical composition and template properties of DNP]. | Electrophoretic mobility, amino acid composition and salt dissociation of histones isolated from sperm of sea urchin Strongylocentrotus intermedius and calf thymus cells were studied. The special arginine-rich histone fraction (I) has been observed in sea urchin sperm chromatin, this fraction being absent in calf thymu... | 567,276 | [
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0.2311133,
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Deformed erythrocytes in muscular dystrophies. | Because of previous reports of a possible correlation between echinocytogenesis and muscular dystrophies, we investigated the time-dependent development of echinocytes in the blood of normal subjects, patients, and healthy carries of Duchenne dystrophy. There was a quantitatively significant increase of echinocytes in ... | 567,302 | [
-0.1321384,
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0.3734335,
0.2150066,
0.0234850... |
Stage II carcinoma of the endometrium. An analysis of treatment. | An analysis of 41 patients with histologically documented Stage II adenocarcinoma of the endometrium treated between 1969 and 1974 is presented. The 3-year survival for all patients was 46%. Patients treated with radiation therapy alone (tandem, ovoids, and external radiation therapy) had 29% survival while patients tr... | 567,310 | [
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0.4542608,
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0... |
Galactorrhea, amenorrhea, hyperprolactinemia, and an empty sella. | Increased serum prolactin (hPRL) and increased volume of the sella turcica as detected by roentgenography are compatible with a pituitary adenoma. The empty sella syndrome can increase sella volume, but is usually associated with minimal, if any, endocrine dysfunction. The present case details a young woman with amenor... | 567,311 | [
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0.09124577,
-0.03750486,
0.03578445,
0.2033... |
Diagnostic value of androgen measurements in polycystic ovary syndrome. | A group of 51 women with a diagnosis of polycystic ovary syndrome (PCO) were investigated. They were further classified into PCO Type I and PCO Type II based on clinical and laboratory investigations. Serum levels of unbound (free) and total testosterone, testosterone binding globulin (TBG), and androstenedione were me... | 567,313 | [
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0.1895817,
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0.5011983,
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0.1237433,
0.2311448,
-0.2925609,
... |
Medullary and carotid chemoreceptor interaction for mild stimuli. | The interaction of medullary and carotid chemoreceptors during mild stimulation was investigated in 44 experiments on 6 chloralose-urethane anesthetized mongrel dogs using a donor-perfused, bilateral carotid sinus preparation. The donor dog breathed hypoxic mixtures (average PaO2 of 78 mm Hg) and the experimental anima... | 567,331 | [
-0.1742955,
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0.154629,
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0.07609658,
0... |
Distribution of the myocardial tissue PO2 in the rat and the inhomogeneity of the coronary bed. | The structural inhomogeneity of the myocardial capillary bed is stimulated by microcirculatory units (MCU's) in a diffusion model. This stimulation is based on MCU's in which the arrangement of the capillary ends (concurrent structure, partial and total countercurrent (structure, helical structure) as well as the struc... | 567,333 | [
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-0.3528987,
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-0.033623,
0.2440455,
0.1929159,
0.09483669,
0.3875381,
0.1542991,
0.255613,
... |
Phenylalanine depletion for the management of phenylketonuria: use of enzyme reactors with immobilized enzymes. | Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and in vivo for depletion of phenylalanine in circulating blood. Sustained reduction of phenylalanine was achieved in less than 30 minutes. A 50% decrease of phenylalanine was obtained with a 2-hour application of enzyme reac... | 567,372 | [
-0.06447825,
0.04071062,
-0.1391836,
0.1395814,
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0.02974419,
0.076803,
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0.2767384,
0.06601732,
0.1219405,
0.2043474,
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0.2265948,
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0.01168168,
-0.2800862,
0.1709097,
-0.2051672,
0.1886928,
-0.2129487,
... |
The relationship between induced mutation frequency and chromosome dosage in established mouse fibroblast lines. | The frequencies of induced mutation to ouabain (OUA) and 6-thioguanine (6TG) resistance were compared in two established mouse fibroblast lines with different doses of the active X chromosome. The activity states of the X chromosomes were determined by DNA replication studies. Mutation frequency to 6TG R, an X-linked r... | 567,385 | [
0.1376285,
-0.009505753,
-0.3058999,
0.1323755,
0.07343672,
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0.1601829,
0.24378,
0.06047089,
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0.2231279,
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0.335999,
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0.2214045,
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-0.08043654,
0.0773503,
0.337713,
0.2309672,
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-0.415956,
-... |
[Effect of cycloheximide on the ultrastructure and several metabolic processes of the cells of an SPEV culture. II]. | The action of cyclohexamide (in doses of 1 and 10 mkg/ml in the course of 24 hours) on porcine embryo kidney cells in culture is accompanied by a powerful suppression of protein and DNA synthesis, mitotic activity, a weaker suppression of RNA synthesis, a lowering of the activity of succinate-, lactate- and alpha-glyce... | 567,393 | [
0.01102906,
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0.07398449,
0.2143225,
0.4273378,
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0.338405,
0.06071571,
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0.1658782,
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0.5104368,
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0.0514099,
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-0.06484311,
-0.2996739,
0.626534,
0.5216082,
0.163122,
-0.1712158,
-0.0... |
[Electrophoretic patterns of differently prepared fibrinogen subunits in sodium dodecyl sulfate containing polyacrylamide gels]. | The electrophoretic behaviour of mercapto, carboxamidomethyl, carboxymethyl and thiosulfonic acid derivatives of rabbit fibrinogen subunits was investigated electrophoretically in sodium dodecyl sulfate containing polyacrylamide gels. Comparing carboxymethyl, carboxamidomethyl and thiosulfonic acid derivatives with the... | 567,415 | [
-0.1630962,
0.2364766,
-0.2269917,
-0.103531,
0.0578629,
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0.07417066,
0.0286615,
0.1774851,
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0.09548073,
0.3607435,
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0.001939059,
0.2192422,
0.4219778,
0.0833137,
-0.09777112,
-0.04138637,
... |
Results of argon laser photocoagulation in presumed ocular histoplasmosis. | We performed argon laser photocoagulation on 31 eyes of 30 patients with presumed ocular histoplasmosis. Nineteen of 25 eyes (76%) with neovascular membranes 0.25 disk diameter or further from the fovea had 6/12 (20/40) or better vision after an average follow-up period of 20 months. Twenty-two of these eyes (88%) had ... | 567,434 | [
-0.06060052,
-0.06200171,
-0.2986793,
-0.1117476,
-0.06130956,
-0.1593238,
0.2295621,
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0.131787,
-0.1734171,
0.2795236,
-0.06312115,
0.005575126,
-0.3551262,
0.1109733,
-0.2088483,
-0.1609132,
0.005362115,
0.06878324,
-0.4182328,
0.03137656,
0.01573911,
-0.138... |
Effects of starvation on the oocytes of Cyprinus carpio--a cytomorphological and histochemical study. | Effects of induced starvation on the morphology of the oocytic nucleus in Cyprinus carpio have been studied to assess the nature of structural aberrations caused and the adaptations induced in the oocytes during the period of stress on account of inanition. An attempt has also been made to study the fate of a number of... | 567,447 | [
0.1122041,
0.1536535,
0.292956,
0.04539911,
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0.01049291,
0.2713393,
-0.0005546673,
-0.138411,
-0.02821296,
-0.1705646,
0.3307731,
-0.1661984,
-0.1804151,
-0.4153146,
0.2355553,
0.3144453,
-0.04757271,
0.2163233,
0.1664965,
-0.1618864,
... |
The effects of lithium on phenylethylamine behavior in rats are counteracted by monoamine oxidase A and B inhibitors. | Rats given a subcutaneous injection of beta-phenylethyl-amine (PEA) (30 or 60 mg/kg) showed stereotyped behavior and autonomic effects which were suppressed by LiCl. Inhibition of Type A MAO by clorgyline or Lilly 51641 (2 or 8 mg/kg) or of Type B MAO by l-deprenyl (2 or 8 mg/kg) counteracted the suppressant effects of... | 567,462 | [
0.08046001,
0.108271,
-0.2842923,
-0.2536859,
-0.01851301,
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-0.4109507,
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0.01285596,
0.1370992,
0.6982549,
0.1989319,
0.4168977,
-0.06127587,
0.2690898,
-0.3560101,
0.08948327,
0.08215079,
0.1582721,
0.05462079,
0.2875292,
-0.002767353,
... |
[Aprotinin and the cardiac, intestinal and uterine musculature. Experimental studies in vitro]. | Aprotinine had no significant effect in vitro on rat and frog heart, pregnant and non-pregnant rat uterus, rat duodenum, and guinea-pig ileum. On the other hand, aspecific depression of cardiac intestinal and uterine muscle was noted when concentrations higher than those recommended or clinical use were employed. | 567,467 | [
-0.08109131,
-0.2723623,
-0.151837,
0.226763,
0.1629611,
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-0.3664832,
0.1952102,
0.1837481,
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0.1314675,
0.3098492,
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0.02922604,
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0.1392456,
-0.1463688,
0.1627662,
-0.1020579,
-0.01886305,
-0.03364165,
0... |
Studies on the proteins of Poecilocera picta. I-changes taking place in the haemolymph protein during moulting. | The haemolymph proteins of the 6th nymph of P. picta were fractioned by the polyacrylamide gel disc electrophoresis. A total of seven proteins fractions have been detected from the haemolymph. The chemical nature of different protein fractions have been examined by histochemical methods. The changes taking place in the... | 567,481 | [
0.1541947,
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-0.1826335,
0.1148811,
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0.00299323,
0.1021491,
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-0.1603619,
0.01525215,
-0.05886184,
0.0643009,
-0.1032837,
-0.3983702,
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-0.3579046,
0.06281041,
0.3467899,
0.05525813,
0.1144048,
0.3925601,
-0.2848702,
... |
Terbium as a solid-state probe for RNA. | This paper continues previous work on the analysis of nucleic acid-terbium complexes in the solid state. The fluorescence excitation and emission spectra of the RNA-terbium(III) complex is reported. The fluorescence excitation and emission spectra of both the RNA-terbium(III) and DNA-terbium(III) complexes as trapped o... | 567,496 | [
-0.1261393,
0.1341654,
-0.1146223,
0.09814235,
0.01187521,
-0.02116609,
-0.288074,
0.27836,
0.1336838,
0.02452513,
0.01571426,
-0.08445355,
0.1127962,
-0.2426186,
-0.44794,
0.02379602,
-0.2857311,
0.04497321,
-0.1990006,
0.3060811,
0.2854813,
-0.03868156,
-0.1413142,
-0... |
Cell-free synthesis of cod preproinsulin. | Poly(A)-containing ribonucleic acid from cod islet greatly stimulated the incorporation of radioactive amino acids into proteins when assayed in a wheat germ translation system. The translation products were examined by specific immunoprecipitation with guinea pig anti cod insulin antibodies and by extraction with acid... | 567,518 | [
-0.03116517,
-0.1094241,
-0.08416172,
0.5138491,
0.1608967,
-0.1514612,
-0.0788767,
0.3686446,
0.1357068,
0.2253354,
0.09081471,
-0.1900953,
0.1213782,
-0.3654407,
0.246302,
0.1077466,
-0.511359,
0.2986888,
0.04267815,
0.1301728,
0.4886999,
-0.06255209,
-0.2921235,
-0.1... |
The circadian variations in the epithelial growth of the hamster cheek pouch: quantitative analysis of DNA distributions. | The pronounced diurnal rhythm in DNA distributions of the hamster cheek pouch epithelium both in the S fraction and in the (G2 + M) fraction was compared with previous studies of the changes in tritiated thymidine labelling index and mitotic activity. The DNA distributions were obtained by flow cytometry after ultrason... | 567,526 | [
-0.07098,
-0.1162415,
-0.3979303,
-0.3003691,
0.3876479,
-0.3874668,
-0.04975278,
0.1481957,
0.5306752,
0.08153875,
0.1596906,
-0.2771674,
-0.01516024,
-0.06492268,
-0.4596145,
-0.1590053,
-0.101509,
-0.0552619,
0.1214741,
0.2600707,
0.4222603,
-0.1282806,
-0.1339449,
-... |
Nucleic acid profile of the EMT6 cell cycle in vitro. | Simultaneous RNA and DNA estimations were carried out during the cell cycle of EMT6/M/CC cells growing in vitro following synchronization by mitotic selection. The determinations were performed with a flow cytofluorimeter on individual cells stained with acridine orange. It was found that the RNA content increased duri... | 567,527 | [
-0.2252091,
-0.1777228,
-0.2960118,
-0.1654912,
0.1733574,
-0.05114584,
-0.1419526,
-0.08114682,
0.2599038,
0.1185123,
-0.0529234,
0.3347465,
0.187775,
0.01730293,
-0.584101,
0.068912,
-0.08565117,
0.1238895,
-0.3284772,
0.04493126,
0.5420621,
-0.1486908,
0.1266067,
0.1... |
Studies on the time and localization of the puberal desensitization to oestrogen in female rats. | Immature and postpuberal female rats were ovariectomized at 20 or 27 days of age or on the day of the first vaginal oestrus and chronically implanted with oestradiol benzoate (OB) and cholesterol at the ratios of 1 : 60, 1 : 120 or 1 : 240 on the day following castration. Autopsy was performed on day 6 after implantati... | 567,576 | [
0.05076598,
0.08499442,
0.125645,
0.04986743,
0.05948463,
-0.2989149,
-0.1755385,
-0.08566839,
0.01037015,
0.2926736,
0.1207734,
0.03337109,
0.1885951,
-0.09221799,
-0.6690694,
-0.1762565,
-0.2382229,
0.201179,
0.2754547,
0.112644,
0.2498335,
0.4673736,
-0.03184171,
0.0... |
Comparative effects of penfluridol on circling behavior and striatal DOPAC and serum prolactin concentrations in the rat. | A single s.c. injection of penfluridol (3 mg/kg) to rats elevated serum concentrations of prolactin for more than 96 h whereas it increased striatal concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and inhibited apomorphine-induced circling behavior for less than 48 h. The dose of penfluridol needed to elevate ... | 567,584 | [
-0.0630096,
-0.2562375,
0.08299863,
-0.5594569,
0.3159519,
-0.1442126,
-0.1979421,
-0.1284132,
0.06341327,
0.05965318,
0.138152,
0.1915015,
-0.1697082,
0.3210392,
0.01725555,
-0.1203518,
-0.4914232,
0.09025996,
0.01646865,
0.2630742,
-0.1119862,
0.3877959,
-0.07678209,
... |
The role of the cholinergic system in the development of increased naloxone potency in mice. | Pretreatment of mice with the anticholinesterase (anti ChE) drugs tacrine or physostigmine augmented the antinociceptive potency of morphine given 3 h later, but had no effect on the antogonist potency of naloxone. Pretreatment with either of these anti ChE drugs together with morphine not only augmented the potency of... | 567,586 | [
0.1056705,
0.1601869,
-0.2867601,
-0.06486399,
0.07467718,
0.1703721,
-0.230033,
0.08431077,
0.2801068,
-0.2282707,
0.03046305,
0.09556565,
0.1570418,
0.03427836,
-0.4689687,
-0.01378861,
-0.2768486,
0.5359585,
0.3319853,
0.1402588,
-0.04026879,
-0.2791125,
-0.06503544,
... |
[Spatio-temporal analysis of contraction dependent surface movements in Physarum polycephalum (author's transl)]. | Plasmodial veins of Physarum polycephalum were investigated by combining cinematographical and tensiometrical methods. Veins remaining on their original growing substrate show characteristic surface movements resulting from an intrinsic contraction automaticity. Radial and longitudinal components of surface movements w... | 567,599 | [
-0.004921676,
-0.05381056,
-0.3132528,
0.2313783,
-0.08561087,
-0.2675281,
-0.1571399,
0.01520415,
0.1308289,
-0.01582602,
-0.001757561,
-0.1649087,
-0.2202529,
-0.2031422,
-0.2260263,
0.07183931,
-0.3352328,
0.2165888,
-0.2634432,
0.1624798,
0.7671235,
0.24195,
-0.191462... |
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