title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Kinetics of nornicotine and anabasine nitrosation in relation to N'-nitrosonornicotine occurrence in tobacco and to tobacco-induced cancer. | The kinetics of nornicotine and anabasine nitrosation, studied in aqueous solution, obeyed equations typical for the nitrosation of aliphatic secondary amines, with third-order stoichiometric rate constants of 1.15 (nornicotine) and 0.86 (anabasine) M-2 sec-1. The similarity of the two rate constants suggested that the... | 561,854 | [
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[Testosterone-7alpha-3H uptake by the anlage of organs related to reproduction in female rate embryos in experiments in vivo and in vitro]. | The dynamics of testosterone-7alpha-3H (T-3H) uptake by the developing genital system organs, as well as by the suprarenals, brain cortex and muscles was studied in vivo experiments with the 14-20 days old female rat embryos. Besides, the T3H uptake by the reproductive tract tissues and muscles just after the isolation... | 561,924 | [
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[Induction of oocyte maturation at stages of incomplete vitellogenesis in toads and the starred sturgeon]. | The intracellular injection of cytoplasm from the maturing oocytes of X. laevis and A. stellatus in oocytes of the same species which did not complete the vitellogenesis and are not able to mature under the effect of progesterone resulted in the disintegration of the germinal vesicle membrane in the oocytes of all size... | 561,926 | [
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[Invariance of asymmetric cleavage during structural changes in Pulmonata zygotes]. | The zygotes of Lymnaea stagnalis L. were centrifuged and, as a result, normal and small size zygotes were obtained. The small zygotes either contained the major part of heavy yolk granules and were characterized by complete cortical polarity, or were devoid of heavy yolk and significant part of vegetal cortex. Followin... | 561,927 | [
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Stapedectomy and fatal meningitis. A human temporal bone study. | Temporal bone histopathology is reported on a case of acute suppurative otitis media, acute suppurative labyrinthitis, and meningitis with death of the patient 20 days after stapes surgery. Purulent exudate invaded the vestibule by the oval window through a displaced footplate. The main pathway of infection to the meni... | 561,934 | [
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Antibodies specific to two deoxyribotrinucleotide sequences. | Antibodies to the deoxyribotrinucleotides dpApTpA and dpApApT were prepared by injecting the bovine serum albumin conjugates of the respective haptens in rabbits. The specificities of the antibodies were determined by estimating the inhibition of the binding of the tritiated haptens to the immunoglobulins by various no... | 561,950 | [
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A new technique for simultaneous urethrocystometry including measurements of the urethral pressure profile. | A new standardized technique for continuous recording of the urethral pressure profile simultaneously with intravesical pressure has been developed. The pressure are recorded using two microtransducers enclosed in a thin Dacron catheter. The catheter is moved at a constant speed through the urethra with the aid of a sp... | 562,017 | [
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Immune mechanism of rats on Nippostrongylus brasiliensis in vitro. II. The influence of lymphocytes and peritoneal cells. | Nippostrongylus were collected from the intestines of rats 6 days p.i. and kept under sterile conditions in cultures. Serum, lymphocytes and peritoneal cells of immune or non-infected animals were added in various combinations to the culture media. The culture media were changed 2-3 times in an experimental period of 1... | 562,037 | [
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[Cadmium uptake by mushrooms (author's transl)]. | Mushrooms of the subgenus Rubescentes (for example Agaricus bisporus and Agaricus campestris) accumulate for less cadmium than most species of the subgenus Flavescentes (for example Agaricus arvensis and Agaricus silvicola). Hence it appears there is no danger for human health, from too much cadmium, when eating the of... | 562,042 | [
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Microcephaly with peculiar demyelination mimicking Pelizaeus-Merzbacher disease. | The neuropathological studies of a 4-year old idiot with microcephaly revealed a striking demyelinating disease compatible with Pelizaeus-Merzbacher disease. The case seemed to be best classified as the patchy demyelination type, but the most unusual finding was a prominent vasculature in some demyelinated areas. Intra... | 562,057 | [
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The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. | Coronary heart disease (CHD) risk factors were studied in 250 monozygotic (MZ) and 264 dizygotic (DZ) male veteran twin pairs, aged 42-56. All coronary heart disease risk factors studied showed significant correlations in both MZ and DZ twins. Substantial genetic variation was detected for height, blood pressure, gluco... | 562,066 | [
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Phagocytosis of spermatozoa by the rabbit vagina. | Twenty-four hours after mating in the rabbit, numerous spermatozoa are observed attached to the surgace of the vaginal epithelium. Spermatozoa appear to be attached by their heads to microvilli of the simple columnar cells which compose the vaginal epithelium. Spermatozoa are taken up by the epithelial cells, and they ... | 562,081 | [
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Secretion of granules by the luteal cells of the sheep and the goat during the estrous cycle and pregnancy. | The fine structure of luteal tissue from sheep and goats at the mid-stage of the estrous cycle and during pregnancy was examined. At the mid-stage of the estrous cycle, when the corpus luteum of both species is secreting progesterone, the ultrastructure of the luteal cells is similar in that granule secretion is preval... | 562,082 | [
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Effect of chemical sympathectomy on muscle blood flow. | Lumbar chemical sympathectomy using 5% phenol in glycerin alleviated intermittent claudication and improved cutaneous blood flow. This technic permits instituting physiotherapy and exercises to improve collateral circulation. The procedure was performed 56 times on 29 cases. No significant complication was observed. Mu... | 562,089 | [
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Probable amniotic fluid embolism during curettage for a missed abortion: a case report. | Diagnosis of amniotic fluid embolism is difficult in a patient under general anesthesia and may initially resemble several other conditions. Successful treatment requires maintenance of adequate cardiac output and oxygenation and prompt heparin treatment of the disseminated intravascular coagulation. The presented cas... | 562,108 | [
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Autoimmune (idiopathic) thrombocytopenic purpura in pregnancy and the newborn. | The effects of autoimmune (or idiopathic) thrombocytopenic purpura (ATP) on 51 pregnancies in 29 women is presented. There is no convincing evidence that the clinical course of ATP is influenced by pregnancy. There was no increased incidence of obstetric complications. No problems were encountered following spontaneous... | 562,177 | [
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Biochemical and immunological characterization of two distinct variants of histone H2A in Friend leukemia. | Changes in the relative amount of two histone H2A subfractions have been observed in cells at different proliferative stages of Friend leukemia. Biochemical analyses of the purified H2A subfractions reveal them to be different in primary structure, and not the result of postsynthetic modifications of the same parent pr... | 562,183 | [
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Characterization of Allomyces genome. | Allomyces arbuscula DNA isolated from whole cells (bulk DNA) is composed of a major (alpha) and two minor components (beta & gamma) with buoyant densities in neutral CsCl corresponding to 1.721, 1.710 and 1.702 g/cm3, respectively. The DNA obtained from purified nuclei contains alpha component only. The beta compon... | 562,187 | [
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[Duration of mitosis in the corneal epithelium and spleen cells of mice with leukemia La]. | Mitotic fluctuations during 24 hours and duration of motoses were studied in the corneal epithelium and in the leukemic-La spleen cells of mice. The existence of correlative changes between the mitotic index and the duration of mitosis in the course of 24 hours was revealed. It is supposed that a more rapid course of m... | 562,209 | [
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Long-term treatment of Paget's disease of bone with salmon calcitonin. | Twenty-eight patients with symptomatic Paget's disease of bone were treated with synthetic salmon calcitonin for periods of 9 to 42 months (average, 23 months). Serum alkaline phosphatase concentration and urinary hydroxyproline excretion, which had been elevated before treatment, were decreased by calcitonin treatment... | 562,231 | [
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Distribution of testosterone-estradiol binding globulin (TeBG) in the higher vertebrates. | The presence of testosterone-estradiol binding globulin (TeBG) in a variety of higher vertebrate species has been investigated by an ammonium sulphate precipitation technique. TeBG has been demonstrated in significant amounts in primates, carnivora, marsupiala, and some artiodactyla, even in circumstances where previou... | 562,259 | [
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The HLA system and the genetics of juvenile diabetes mellitus. | Eighteen families with a total of 68 children were completely typed for HLA-A, B, C, D and Bf. With only one exception, all affected children within each family with 2 or more diabetic siblings, shared both HLA-D alleles indicating that J.D.M. is a recessive trait. Since half of the siblings who are HLA-D identical to ... | 562,286 | [
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Congenital cerebrospinal hypomyelinogenesis in a pup. | One of 8 highly inbred Dalmatian pups was born with generalized body tremors, which interfered with the pup's ability to suckle, walk, and maintain sternal recumbency. The pup's head, neck, and limbs oscillated rhythmically when it attempted to perform any motor function. The pup was euthanatized at 8 weeks of age, aft... | 562,333 | [
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Selective formation of certain amino acids from formaldehyde and hydroxylamine in a modified sea medium enriched with molybdate. | Amino acids produced from formaldehyde and hydroxylamine in modified sea mediums with different concentrations of molybdate were analyzed. The modified sea mediums contained lower concentration of sodium chloride and higher concentrations of transition metal ions (Zn2+, Fe3+, Cu2+, Co2+, Mn2+ each 10(-4)m, and Mo O4(2-... | 562,340 | [
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[Antenatal diagnosis of fetal sex. Method and implications]. | An outline of fetal antenatal sex determination and its diagnostic methods are rapidly enumerated. Actual methods are based on direct and indirect identification of sexual chromosomes from three types of cells : desquamated ones in amniotic fluid, fetal lymphocytes circulating in maternal blood and desquamated chorioni... | 562,363 | [
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Long-term unmaintained remissions after agressive multidisciplinary treatment of advanced non-seminomatous testicular germ cell tumors. | Five patients with disseminated non-seminomatous testicular germ cell tumors are described. These patients have been clinically free of disease for 25 to more than 99 months and may be cured, since the interval after last treatment ranges from 13 to more than 76 months. Two patients, including 1 with pure choriocarcino... | 562,424 | [
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An explanation for the persistence of residual urine after external sphincterotomy. | After external urethral sphincterotomy 7 patients were found to have residual urine in excess of 80 ml. By measurement of the urethral pressure and analysis of the cystometrogram it was found that these patients fail to sustain bladder contraction and, thereby, fail to empty the bladder completely. | 562,427 | [
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[Computer assisted heart and circulation analysis in experimental septic shock (author's transl)]. | Developping a model of shock applying to the clinical manifestation is necessary to investigate the pathogenesis of septic shock and to identify the letality causing organ. Perhaps the hyperkinetic syndrome may play an important role. The extensive experimental data is processed by a digital computer. Explanations are ... | 562,439 | [
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0.08793747,
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0.1140739,
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0.01652021,
-0.6794327,
0.1570319,
0.1802147,
0.2682985,
-0.1386969,
0.01890875,
0.2741339,
-0.04744687,
-0.3686669,
-... |
A radioimmunoassay of primary bile acid conjugates in human serum. | The fasting levels of chenodeoxycholic and cholic acid conjugates in various groups of patients [25 healthy subjects, 20 patients with chronic active liver disease (CALD), 21 patients with primary biliary cirrhosis (PBC) and 5 patients with cholesterol gallstones before and after chenodeoxycholic acid therapy] were det... | 562,528 | [
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-0.0859... |
Chromosome loss is responsible for segregation at the HPRT locus in Chinese hamster cell hybrids. | The phenomenon of segregation of gene expression has been examined in intraspecific somatic cell hybrids. Specifically, segregation at the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus has been studied in hybrids of Chinese hamster cell lines. The role of chromosome segregation, or other chromosomal event... | 562,539 | [
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0.01094124,
-0.03899735,... |
Effect of caffeine on urethral pressure. | Urethral pressure profiles have been a useful adjunct in the study of continence. Caffeine, a known smooth muscle inhibitor and skeletal muscle stimulator, is shown to decrease the urethral pressure profile in anesthetized dogs. This would lead one to believe that the smooth muscle component of urethral tonus is the de... | 562,550 | [
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... |
A male MZ twin pair, concordant for transsexualism, discordant for schizophrenia. | A pair of male monozygous twins of gynandromorphic habitus but normal male body hair and genitalia, who appear concordant for transsexualism and explosive personality disorder but discordant for schizophrenia, is presented. No evidence of specific family dynamic factors, imitative learning or folie a deux was found in ... | 562,589 | [
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0.1285548,
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Genetic studies in outpatients: plasma cholesterol in family and twin studies. | Quantitative genetic studies have much potential in partitioning the causes of variation of quantitative traits such as risk factors for atherosclerosis. Only if specific causes of variation are identified can specific therapy be developed to modify risks. There have been extensive family studies of plasma cholesterol ... | 562,595 | [
0.03023231,
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0.16903,
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Elastic tissue in the limiting membrane of the human seminiferous tubule. | The structure and distribution of elastic tissue were studied in the limiting membrane of the seminiferous tubule from normal human testis. The elastic and elastic-related fibers (oxytalan and elaunin) were recognized by their tinctorial and ultrastructural characteristics. The connective structures of the limiting mem... | 562,618 | [
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0.5543897,
0.2560136,
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[Pseudo-angiosarcomatosis (kaposi) and arterio-venous fistulae (author's transl)]. | In a few cases, arterio-venous fistulae of the lower limbs lead to cutaneous symptoms of the toes, feet or legs exactly similar to Kaposi's disease; the fairly precocious occurrence, the unilateral localisation, the existence of clinical and radiological arterial symptoms and usually, but not always, particular histolo... | 562,637 | [
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0.1777797,
0.1467091,
0.2057831,
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... |
The effects of ethanol and pentobarbital on the naloxone precipitated escape response in morphine dependent mice. | Morphine dependence in mice is produced in a two day test. The effects of (1) ethanol, (2) pyrazole, (3) ethanol with pyrazole, and (4) pentobarbital are observed and recorded on the naloxone precipitated escape response in morphine dependent mice. Ethanol suppresses the escape response in doses of 2.0 and 3.0 g/kg whi... | 562,645 | [
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0.2446141,
0.07620402,
0.3716882,
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0.0856522... |
The radiological investigation of intramedullary spinal tumours. | The place of the various radiological techniques in the diagnosis of spinal cord tumours is described. With appropriate regard to the clinical picture, the choice of selective angiography. Metrizamide or Myodil myelography, and possible cyst puncture and endomyelogram, may be made with accuracy. Air myelography is less... | 562,669 | [
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0.132894,
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0.05284272,
0.4644817,
0.01073372,
0.039199... |
Comparative epidemiology of tobacco-related cancers. | In a retrospective study, interviews were obtained with 3,716 patients with histologically proven cancer of the lung (Kreyberg types I and II), mouth, larynx, esophagus, or bladder and with over 18,000 controls. For each of these cancers, the relative risk of both male and female present smokers increased with the quan... | 562,711 | [
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0.5859402,
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0.4937915,
0.3424776,
0.05393176,... |
Changes in the mRNA population of chick myoblasts during myogenesis in vitro. | We have analyzed the sequence complexity, frequency distribution and coding capacity of the mRNA populations of primary chick embryo muscle cultures at different stages of myogenesis. Prefusion cultures, fused myofibrillar cultures and cultures blocked for both fusion and myogenesis all contain about 17,000 different m... | 562,718 | [
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0.1215292,
0.7254093,
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... |
Conservative assembly and segregation of nucleosomal histones. | The assembly of new histones into nucleosomes and the segregation of old histones during replication were investigated using a density gradient, sedimentation equilibrium analysis of histones labeled in vivo with dense amino acids. After a 1 hr pulse of dense amino acids and 3H-lysine, nucleosomes were isolated from ch... | 562,720 | [
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0.2842523,
0.2178185,
-0.1215851,
-... |
Genome analysis of Peromyscus (Rodentia, Cricetidae) VII. Localization of satellite DNA sequences and cytoplasmic poly(A) RNA sequences of P. eremicus on metaphase chromosomes. | A satellite DNA fraction from P. eremicus, having a buoyant density of 1.705 g/ml in neutral CsCl density gradients, was isolated. In situ hybridization experiments, using 3H-RNA complementary to this DNA fraction indicated that the short (heterochromatic) arms of most of the autosomes contained this sequence. Converse... | 562,738 | [
0.3358572,
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0.2655132,
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0.2263932,
-0.309... |
Analysis of calf-thymus satellite DNA: evidence for specific methylation of cytosine in C-G sequences. | Digestion of purified calf tymus satellite I (phi = 1.714 g/cm3) with a series of restriction enzymes shows that modification in this satellite occurs preferentially in the sequence C-G. This was also shown to be the case in the other satellites and in bulk chromosomal calf thymus DNA. Cloning of purified satellite I D... | 562,751 | [
0.321385,
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[Effect of chloroquin on the experimental sensitization with penicillin]. | In penicilline-sensitized mice it was possible to decrease the titers of haemagglutinating antibodies by cholroquine. | 562,784 | [
0.05563078,
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0.02832399,
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Identification of an androgen receptor in the cytosol of the female Mastomys prostate. | An in vivo and in vitro study was carried out on the prostate from the female Praomys (Mastomys) natalensis to identify and characterize the binding of androgens within the cytoplasm. The labelled cytosol was prepared and subjected to gel exclusion chromatography and density gradient centrifugation. A macromolecular pr... | 562,799 | [
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0.417126,
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0.1496674,... |
Motility of triton-demembranated sea urchin sperm flagella during digestion by trypsin. | The survival curves for a population of reactivated spermatozoa exposed to digestion by trypsin indicate that a large number of trypsin-sensitive targets must be digested before the flagellum disintegrates. Changes in flagellar movement during trypsin digestion can be very small, especially when the spermatozoa are rea... | 562,884 | [
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0.1436244,
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A study of communication specificity between cells in culture. | We have examined the specificity of communication between cells in culture by co-culturing cells derived from mammalian, avian, and arthropod organisms. Both mammalian and avian culture cells have similar gap junctional phenotypes, while the insect (arthropod) cell lines have a significantly different gap junctional st... | 562,887 | [
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0.09752616,
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0.1009097,
0.00762043... |
Synchrony in the rhythm of the contraction-relaxation cycle in two plasmodial strands of Physarum polycephalum. | Rhythmicity of contraction of plasmodial strands of Physarum polycephalum was studied, by measuring the isometric tension exerted by isolated segments of the strands. When 2 strands were connected by way of a plasmodial mass, the contraction-relaxation cycle of the 2 strands synchronized. Such cycle activity of the str... | 562,892 | [
-0.3404804,
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0.4520072,
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Regulation of reaginic antibody production in mice. I. Suppression by antigen of IgE antibody production in vitro. | Regulation of IgE production by antigen in a primed murine splenic lymphocyte culture system was described. Maximum IgE antibody production was found to occur when cells were cultured in the absence of exogenously added antigen. A cells and T lymphocytes did not affect the production of anti-DNP IgE antibody. By using ... | 562,920 | [
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... |
Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii. | Bioassay-guided fractionation of the aqueous alcoholic extract of the marine sponge Verongia spengelii for tumor inhibitory agents led to the isolation of aplysinopsin, a new tryptophan derivative recently reported from another sponge Thorecta aplysinopsis. Aplysinopsin showed cytotoxicity against the KB, P388 and L121... | 562,965 | [
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0.1593567,
0.253566,
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0.... |
A new juvenile hexosaminidase deficiency disease presenting as cerebellar ataxia. Clinical and biochemical studies. | A boy with mild hand tremor since age 2 1/2 was found at 4 to have cherry-red spots and mild trucal ataxia without seizures or dementia. Biochemically, he had striking hexosaminidase deficiency (serum: 4.6 percent of normal, 88.9 percent heat-labile; leukocyte: 2.2 percent of normal, 84.6 percent heat-labile; fibroblas... | 562,995 | [
0.1852757,
-0.3064155,
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-0.4900436,
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0.1329708,
0.01164737,
0.157077,
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Acetylcholine receptors of aneurally cultured human and animal muscle. | We describe the diffuse nonjunctional distribution of AChR molecules of aneurally cultured human and animal muscle and the influence of sera from myasthenia grivis patients and rabbits with experimental autoimmune myasthenia gravis on binding of alphaBT to diffuse nonjunctional AChR. One-hour incubation of myasthenia g... | 562,996 | [
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0.03609094,
0.04210711,
0.4010741,
0.09516601,
-0.... |
Experiences with a new ergoline (CF 25-397) in parkinsonism. | Studies on rats with unilateral nigral lesions suggest that a new ergoline, CF 25-397, is a dopaminergic agonist that might improve parkinsonism. CF 25-397 induces less stereotyped behavior than other dopaminergic agents in rats, and might therefore cause less dyskinesia than levodopa in man. We investigated the clinic... | 563,012 | [
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0.1824478,
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0.2626326,
-0.1957698,
0.176088,
-0.033... |
[Emergency surgery problems: selective decompression of esophagogastric varices]. | The physiopathological premisses of portosystemic anastomosis and the modern approach to this question are explained. Stress is laid on the general and haemodynamic advantages offered by selective shunts and 6 cases (4 distal splenorenal and 2 coronarocava shunts) are presented. As yet the postoperative period is not l... | 563,024 | [
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0.07859844,
0.05787032,
0.03186617,
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-0... |
Control of the internal anal sphincter (manometric study with human subjects). | Manometric studies of the functions of the internal anal sphincter were performed in 73 children. Twenty-one out of these patients were normal subjects, the others had neurological lesions either central (sacral meningocele, dorsal cord transections) or peripheral (Hirschsprung's disease). It was found that the functio... | 563,054 | [
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0.4093383,
-0.03423347,
0.1929... |
Alkali metal cations: effects on isolation-induced aggression in the mouse. | Alkali metal cations were given in varying doses over 14 days to CF-1, male mice, isolated for 4 weeks prior to testing for isolation-induced fighting. Lithium and cesium in doses of 4.5 and 6.0 meq/kg reduced the duration of isolation-induced aggression in a 15 min test period when compared with controls. Toxicity was... | 563,085 | [
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0.2458215,
-... |
[Review of the effects of cytochalasin B on cell division, cell movemnts, cell exchanges, and cell morphology]. | Cytochalasin B is known to induce quiescence in cells. We present here a comprehensive view dealing with the effects of cytochalasin B on cell division, movements, exchanges and morphology. The controversial mode of action of the drug is also considered. | 563,093 | [
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[Comparative morphological studies of yeast cells using automated image analysis]. | The ultrastructural alterations in cells of Candida utilis caused by the influence of copper ions have been studied by means of quantitative image analysis. A model has been proposed which presents the following informations: The main effect of the copper ions is represented by an increase of the volume of the whole ce... | 563,137 | [
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... |
[Effect of destruction of midbrain raphe nuclei on the behavioral effects of dopaminergic substances and I-tryptophan]. | In experiments on male albino rats, after electrolytic lesions of dorsal and median mesencephalic raphe nuclei, l-DOPA and apomorphine did not exert their stimulating effect on aggressiveness and emotional reactivity, seen in control false-operated animals. The inhibitory effect of haloperidol on emotional reactivity i... | 563,144 | [
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[Glucocorticoid function of the adrenals and the state of the sympathetic-adrenal system in newborn infants with an hypoxic lesion of the central nervous system]. | The convened studies demonstrated an activation of the hypothalamo-hypophysis-adrenal and sympathico-adrenal system in the newborn with slight and moderately expressed forms of CNS lesions. At the same time there was a relative insufficiency of such functions in children with severe forms of CNS lesions. The achieved d... | 563,156 | [
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Effects of a tumor-promoting agent on chondrogenesis. | Chondroblasts exposed to the phorbol ester, PMA, rapidly lose their polygonal morphology, and rapidly cease to synthesize or accumulate the chondroblast-specific Type IV sulfated proteoglycan. This striking effect is reversible if the cells are kept in PMA for up to 72 hours. A longer exposure induces irreversible effe... | 563,167 | [
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The care of patients with phantom limb pain in a pain clinic. | Patients referred to the Pain Clinic at the University of Virginia Medical Center with genuine phantom pain rather than stump pain have been treated by a variety of technics. Simple revision of drug therapy has proved helpful in some instances, as has repeated injection of trigger areas or neuromata, though surgical ex... | 563,190 | [
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Sexual behavior of captive orangutans. | Opposite-sex pairs of orangutans were tested for sexual behavior during the intermenstrual period of the female. The male orangutan was the primary initiator of sexual interactions and initiated copulation forcefully on a daily basis, irrespective of female resistance. However, although single copulations occurred dail... | 563,223 | [
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The problem of uveitis in Bendel State of Nigeria: experience in Benin City. | A review of 1987 patients with uveitis seen over an 11-year period in Bendel State of Nigeria has been undertaken; 56% of cases had a posterior/mid-peripheral uveitis, 15.1% a panuveitis, 21.5% an anterior uveitis. Acute anterior uveitis with classical symptoms was rarely seen. Its comparative rarity is presumably due ... | 563,237 | [
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... |
Localisation and characterization of the fatty acid synthesizing system in cells of Glycine max (soubean) suspension cultures. | In course of a study of fatty acid synthetase in higher plants, non-green cell suspension cultures of Glycine max (soybean) served as model tissues. For the first time, a fatty acid synthesizing system was characterized in cell cultures of higher plants and was found to be solely located in proplastids of the cells. Op... | 563,244 | [
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Glyceride synthesis by four kinds of microbial lipase. | Apart from their usual mechanism of action, lipases from Aspergillus niger and Rhizopus delemar also catalyzed the synthesis of glycerides from oleic acid and glycerol. Lipases from Geotrichum candidum and Penicillium cyclopium were inactivated by oleic acid, but were stable in the presence of casein, albumin or buffer... | 563,245 | [
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Chromosomes and DNA of Microtus. II. Confirmation of deletion of constitutive heterochromatin in M. agrestis cells in vitro. | The distribution of constitutive heterochromatin has been examined by C-banding in two somatic cell lines, grown in vitro, from a female Microtus agrestis. One line retains one intact X chromosome together with the short arm of the other X chromosome, while the other cell line retains only the short arm of one X chromo... | 563,281 | [
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RAST in the diagnosis of hypersensitivity to horse allergens. A comparison with clinical history and in vivo tests. | Case history, skin tests and RAST were compared in a group (n = 40) of children with a history suggesting allergy to horses and in a group (n = 43) in whom there was no suspicion of hypersensitivity to horses. There was an agreement of 91% between case history and prick test. The same magnitude of agreement was found b... | 563,309 | [
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... |
Pulsatile release of luteinizing hormone and the secretion of ovarian steroids in sheep during anestrus. | The peripheral concentration of LH and the secretion rates of estradiol-17beta and androstenedione were measured every 10 min for 4 h during anestrus in six ewes with utero-ovarian autotransplants. The basal concentration of LH was 0.45 +/- 0.06 ng//ml (NIH LH S14; mean +/- SEM), with pulses of LH (6.0 +/- 0.3 ng/ml; N... | 563,321 | [
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The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure. | Study on a diurnal rhythm of plasma aldosterone (PA) and plasma renin activity (PRA) was performed in 8 patients with congestive heart failure. All patients had been digitalized and received diuretics under mild sodium restriction. An obvious diurnal rhythm of PA similar to the normal subjects, with the lowest value in... | 563,323 | [
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Apomorphine-induced locomotion and gnawing: evidence that the experimental design greatly influences gnawing while locomotion remains unchanged. | In a recent study we have shown that it was possible to recognize and record two independent behavioural patterns elicited by apomorphine (s.c.): one behaviour characterized by increased locomotion, sniffing and repetitive head and limb movements and another, characterized by compulsive gnawing. In the present study we... | 563,330 | [
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PSRO: issues in health care policy. | Enactment of the law regarding Professional Standards Review Organizations (PSROs) represents a major shift in health care policy in the United States. PSRO is an experiment in developing a national quality assurance system. It raises issues of quality versus cost control, professional versus public accountability, and... | 563,365 | [
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Commonly asked clinical questions about methadone maintenance. | Clinical questions about methadone maintenance are posed and answered. The areas include eligibility, size of clinic, number of patients, optimal maintenance dose, special populations, side effects, services, schedules, and the involvement of others. | 563,384 | [
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Preparation of 6-epi-ampicillin and of 6-epi-alpha-hydroxybenzylpenicillin. | The preparation of 6-epi-ampicillin by hydrolysis of 6-epihetacillin is described. During this conversion, the formation of a diketopiperazine was also observed. The best yield was obtained at pH 7.0 and room temperature for 3 approximately 7 hours. The lowest yield of 6-epi-ampicillin and the highest formation of the ... | 563,392 | [
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Chemical structure of the active site of pig heart mitochondrial aspartate aminotransferase labeled with beta-chloro-l-alanine. | Formate-induced inactivation of pig heart mitochondrial aspartate aminotransferase by beta-chloro-L-alanine resulted in the modification of the epsilon-amino group of the lysyl residue which is involved in the formation of an aldimine bond with 4-formyl group of the coenzyme, pyridoxal 5'-phosphate. The tryptic peptide... | 563,396 | [
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Continuous DNA replication in the nucleus of the dinoflagellate Prorocentrum micans (Ehrenberg). | The uptake of tritiated thymine into cells of a heterogeneous population of Prorocentrum micans was investigated using light-microscope and electron-microscope autoradiography. Specificity of thymine uptake into DNA was demonstrated by the specific removal of label from wax-embedded material using DNase and by the high... | 563,412 | [
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Protein synthesis in the early Drosophila embryo; analysis of the protein species synthesized. | The soluble proteins were extracted from Drosophila eggs which had been permeabilitzed and incubated in medium containing [35S]methionine. These proteins were analysed on immunoelectrophoresis plates and on SDS polyarcylamide gels both by staining for total protein and by autoradiography. The radioactive proteins must ... | 563,429 | [
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Serum vitamin A in premature and term neonates. | Serum vitamin A was determined in premature and term neonates by a specific spectrofluorometric method. Premature neonates (N = 42; gestational age = 32 +/- 0.4 weeks) had a serum vitamin A level (14.9 +/- 0.98 microgram/dl) significantly lower (P less than 0.001) than that of term neonates (N = 51; 22.4 +/- 0.99 micro... | 563,434 | [
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Three-dimensional molecular illustrations I: Isoelectron density contours and isoelectrostatic energy contours. | A method of depicting dimensional illustrations of molecules in vacuo that are sensitive to small electronic perturbations was attempted. This method would be useful in determining the effects of either perturbing groups from other molecules or changes produced by the addition or modification of an existing atom or che... | 563,440 | [
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Effect of general anesthetics on handling- and decapitation-induced increases in sympathoadrenal discharge. | The effect of five anesthetics--cyclopropane, pentobarbital, urethane, chloralose or ketamine hydrochloride--on handling- or decapitation-induced increases in adrenergic tone were studied in the intact rat. The anesthetic agents tested prevented or markedly reduced stress-induced increases in levels of plasma total cat... | 563,442 | [
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Oestradiol-17beta, progesterone, FSH and LH in prepubertal calves induced to superovulate. | Fluorogestone acetate (vaginal sponge for 4 days) and PMSG (i.m. injection at the time of sponge insertion) treatment was administered to seven 3-month-old calves to induce superovulation. Samples of peripheral plasma were taken every 4 h during treatment (4 days) and then every 2 h for 7 days. FSH, LH, oestradiol and ... | 563,449 | [
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0.200415,
0.01572414... |
Seasonal variation in oestrus, the secretion of oestrogen and progesterone and LH levels before ovulation in the ewe. | Ewes with cervical ovarian autotransplants were studied after PGF-2alpha-induced luteal regression in November and February (mid- and late-breeding season) and June (anoestrum). Progesteron and oestradiol-17beta secretion rates and LH concentrations were determined in serial ovarian venous blood samples and the ewes we... | 563,454 | [
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... |
Spermatogenesis and spermiogenesis in Ascaris lumbricoides Var. suum. | Reorganization of the prophase I nucleus marks the beginning of the first meiotic division. A pair of centrioles is present at each pole at metaphase I and mitochondria are not observed in the spindle area. A chromosomal pellicle, which resembles a kinetochore plate but has no apparent association with microtubules, su... | 563,473 | [
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Ambulatory neurology in residency training programs: a perspective. | Inpatient care and teaching have been the central theme in academic medicine, including neurology, for the last several decades. However, pressures from within and outside of medicine are building to create a renewed commitment to ambulatory care and education. Most neurology training programs have not yet made that co... | 563,535 | [
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Vitamin B6-dependent seizures: pathology and chemical findings in brain. | A 13 1/2-year-old child died with vitamin B6-dependent seizures in progress. Microscopic findings in brain included an abnormally sparse quantity of central myelinated fibers in the cerebral hemispheres. Glutamic acid concentrations were elevated and GABA concentrations reduced in the frontal and occipital cortices but... | 563,538 | [
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Prevalence of epilepsy in Bogota, Colombia. | A combined epidemiologic, clinical, and electroencephalographic study of epilepsy was undertaken in Bogota by the Neurological Institute of Colombia, the Colombian Institute of Health, and the Department of Health of the City of Bogota. The prevalence of epilepsy on December 31, 1974, was 19.5 per 1,000, the highest ra... | 563,543 | [
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0.1574779,
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Ethanol dependence as a determinant of fluid preference. | Rats made dependent on ethanol by a schedule-induced polydipsia procedure preferred 5% ethanol to an increasing concentration of dextrose solution to a greater extent than animals on a non-dependent, non-polydipsic procedure which allowed an equivalent opportunity to drink ethanol, confirming a previous study. Two corr... | 563,602 | [
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Conditioned taste aversions accompanied by geophagia: evidence for the occurrence of "psychological" factors in the etiology of pica. | A conditioned taste aversion procedure was used to produce an avoidance of saccharin by rats. In the first experiment, saccharin consumption was paired with cyclophosphamide in two conditioning trials during which the animals were permitted to engage in pica. In the second experiment, saccharin consumption was paired w... | 563,606 | [
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The effect of changes of posture on the urethral closure pressure in healthy women. | The effect of changes of posture on hydrodynamic parameters considered important for the maintenance of urinary continence was investigated in 14 healthy women. The subjects were investigated in the supine and erect positions using a previously described technique for simultaneous urethrocystometry, including recording... | 563,617 | [
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Comparison of the effects of alcohol, chlordiazepoxide, and delta9-tetrahydrocannabinol on intraspecies aggression in rats. | The species-specific repertoire of attack, threat, defense, and submission was produced in pairs of male laboratory rats and measured after intraperitoneal injection of a drug or its vehicle to one of the rats. Attack behavior by dominant rats toward nondrugged opponents was increased by a low dose of alcohol (0.5 g/kg... | 563,665 | [
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The temporal and volumetric components of stress induced drinking in rats. | Two experiments are presented which describe the temporal and volumetric changes in ethanol consumption with rats exposed to recurring schedules of inescapable random shock stress. The animals in Experiment I had an ethanol and water choice and the data demonstrated cumulative increases in voluntary ethanol consumption... | 563,666 | [
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Interrelationships between maternal and cord prolactin, progesterone, estradiol, 13,14-dihydro-15-keto-prostaglandin F2alpha, and cord cortisol at delivery with respect to initiation of parturition. | Estradiol, progesterone, prolactin, and 13,14-dihydro-15-keto prostaglandin F2alpha (PGFM) were measured in both maternal and cord venous blood obtained at the time of delivery in 24 maternal infant pairs evenly divided among six different physiologic groups. Progesterone and prolactin were significantly higher and est... | 563,675 | [
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Comparison of Streptococcus uberis and S. infrequens. Pathogenicity for cow udder. | The pathogenicity of Streptococcus uberis and S. infrequens for cow udder was compared by experimental intramammary inoculation, mostly during the dry period. There were no significant differences between the two species according to the number and the length of infections at the subsequent lactation (Table 1). No infe... | 563,693 | [
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An interpretation of human diaphorase isozymes in terms of three gene loci DIA1, DIA2 and DIA3. | NADH and NADPH diaphorase isozymes have been studied in human tissues. Evidence from rare heterozygotes suggests that the red cell and main tissue forms of NADH diaphorase are products of the same locus DIA1. NADPH-dependent diaphorase appears to be the product of a second locus DIA2. A third locus, DIA3, codes for the... | 563,699 | [
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The role of splenectomy in the treatment of thrombocytopenic purpura due to systemic lupus erythematosus. | Splenectomy in the treatment of thrombocytopenic purpura associated with lupus erythematosus has afforded satisfactory overall results in a group of ten patients. Postoperative deaths occurred in two patients, each of whom had significant underlying problems. Clinical manifestations of SLE-induced thrombocytopenic purp... | 563,707 | [
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0.04685655,
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0.1985535,
0.058888... |
Lipid-protein globules of avian egg yolk. Isolation and properties of globules stable in concentrated sodium chloride solution. | A new type of globular particle, the 'insoluble yolk globule', was isolated from the egg yolk of three avian species (hen, duck, and emu) by centrifugation or gel-filtration chromatography. These globules are stable in NaCl and urea solutions at concentrations that dissolve or disrupt other constituents of yolk, The is... | 563,717 | [
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Transient-state kinetics of L-glutamate dehydrogenase: mechanism of alpha-ketoglutarate inhibition in the burst phase. | Stopped-flow studies of the initial burst of NADPH production accompanying the oxidative deamination of L-glutamate by L-glutamate dehydrogenase and NADP+ were performed in the presence of alpha-ketoglutarate, a product of the reaction. Both binary enzyme-alpha-ketoglutarate and ternary enzyme--NADP+-alpha-ketoglutarat... | 563,727 | [
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Action of ultrasonic irradiation on the DNA of cultivated bovine epithelial lens cell. | Cultivated epithelial lens cells have been submitted to a 20 kHz continuous ultrasonic irradiation. At relativity high intensity, destruction of the cells was observed. At lower intensities, where no cell destruction appeared, the molecular weight of the single strand DNA of these cells was monitored to determine wheth... | 563,745 | [
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Can social interaction be used to measure anxiety? | 1 Pairs of male rats were placed in a test box for 10 min and the time they spent in active social interaction was scored. Maximum active interaction was found when the rats were tested under low light in a box with which they were familiar. When the light level was increased or when the box was unfamiliar active socia... | 563,752 | [
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The isolation and characterization of a second oocyte 5s DNA from Xenopus laevis. | A second and minor DNA component containing 5s RNA genes has been purified from the genomic DNA of Xenopus laevis (XIt 5S DNA). Some of its physical and chemical characteristics are described. It contains a 5S RNA gene sequence which has some oocyte and some somatic-specific residues, as well as nucleotides which diffe... | 563,770 | [
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The lectin from viscum album L. purification by biospecific affinity chromatography. | A lectin from Viscum album which specifically binds to D-galactose was isolated by affinity chromatography on O-lactosyl-, O-galactosyl-polycarylamide or hydrolized sepharose 4 B. Some serological and physicochemical properties of the agglutination are reported. | 563,801 | [
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... |
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