title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Psoas abscess in children. Report of 6 cases]. | Six children with abscess of the psoas muscle are presented. Previous trauma pain, claudication and antalgic position of a lower limb, fever, abdominal tenderness and leukocytosis were prominet features. Four patients improved and two died. Treatment included surgical drainage and antibiotics. Differential diagnosis an... | 619,929 | [
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Contribution of individual differences in gastric emptying to variability in plasma propranolol concentrations. | 1 No correlation was found between the rate of gastric emptying and peak plasma propranolol concentrations in six hypertensive patients after single oral doses of 80 mg. 2 In four normal subjects given oral propranolol the peak plasma concentration was highest when a simultaneous injection of metoclopramide and lowest ... | 619,945 | [
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Effect of aluminium hydroxide and glycopyrrhonium on the absorption of ethambutol and alcohol in man. | 1 The effect of aluminium hydroxide and/or of glycopyrrhonium on the absorption of a single oral 50 mg/kg dose of ethambutol (EMB) was investigated on thirteen tuberculous in-patients and on two groups of healthy volunteers with six subjects each. The EMB concentrations in serum and 10+h urine were measured by colorime... | 619,949 | [
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Space-time clustering of Burkitt's lymphoma in the West Nile district of Uganda: 1961-1975. | Epidemiological data relating to all 202 patients diagnosed with Burkitt's Lymphoma (BL) in the West Nile District of Uganda in the period 1961 to 1975 have been reviewed and analysed. Statistically significant evidence of space-time clustering of cases, first reported for the period 1961-65, was also present during 19... | 619,954 | [
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Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat. | The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly ... | 619,960 | [
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Influence of overfeeding on growth, obesity and intestinal tract in young chicks of light and heavy breeds. | 1. Heavy-breed (HB) chicks differed from light-breed (LB) ones in their propensity to be overfed. Whereas in the LB chicks the amount by which they could be overfed reached 70% more than the food consumed daily by the ad lib.-fed chicks, in the HB chicks the maximal excess was only 13%. 2. Overfeeding caused a slight b... | 619,976 | [
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Hydrolysis of proteins using dipeptidyl aminopeptidases: analysis of the N-terminal portion of spinach plastocyanin. | The exopeptidases dipeptidyl aminopeptidases I and IV were used to hydrolyze the N-terminal portion of spinach plastocyanin to dipeptides. The enzymes were used individually as well as in a mixture and the dipeptides were analyzed by combined gas chromatography-mass spectrometry. Data are presented for native plastocya... | 620,000 | [
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Picosecond time-resolved study of MgCl2-induced chlorophyll fluorescence yield changes from chloroplasts. | The MgCl2-induced chlorophyll fluorescence yield changes in broken chloroplasts, suspended in a cation-free medium, treated with 3,-(3',4'-dichlorophenyl)-1,1-dimethylurea and pre-illuminated, has been investigated on a pico-second time scale. Chloroplasts in the low fluorescing state showed a fluorescence decay law of... | 620,010 | [
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Picosecond time-resolved energy transfer in Porphyridium cruentum. Part I. In the intact alga. | The wavelength-resolved fluorescence emission kinetics of the accessory pigments and chlorophyll a in Porphyridium cruentum have been studied by pico-second laser spectroscopy. Direct excitation of the pigment B-phycoerythrin with a 530 nm, 6 ps pulse produced fluorescence emission from all of the pigments as a result ... | 620,014 | [
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Picosecond time-resolved energy transfer in Porphyridium cruentum. Part II. In the isolated light harvesting complex (phycobilisomes). | The transfer of excitation energy between phycobiliproteins in isolated phycobilisomes has been observed on a picosecond time scale. The photon density of the excitation pulse has been carefully varied so as to control the level of exciton interactions induced in the pigment bed. The 530 nm light pulse is absorbed pred... | 620,015 | [
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Galactose transport in human erythrocytes. The transport mechanism is resolved into two simple asymmetric antiparallel carriers. | The kinetic properties of the mediated transport of galactose in human erythrocytes are investigated at 20 degrees C. Different methodological procedures are used to acquire a complete kinetic description of the system. Under zero-trans conditions the uptake of galactose is mediated by two distinctly different carriers... | 620,020 | [
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Interaction of methylchymotrypsin with Streptomyces subtilisin inhibitor. | The effect of methylation of histidine-57 of alpha-chymotrypsin with Streptomyces subtilisin inhibitor was examined. Methylchymotrypsin was isolated by affinity chromatography on inhibitor-Sepharose, and the interaction of this inactive enzyme with inhibitor was quantitatively analyzed by two different methods: the spe... | 620,038 | [
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Nuclear proteins. V. Studies of histone-binding proteins from mouse liver by affinity chromatography. | We examined four extracts of mouse liver for histone-binding proteins using histone affinity chromatography and positively charged resins. The extracts used were cytoplasm and washes from isolated nuclei with buffers containing 0.05 M Tris, 0.15 M NaCl or 0.35 M NaCl. Proteins from the nuclear washes showed greater bin... | 620,049 | [
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Interaction of rabbit hemopexin with bilirubin. | The interaction of hemopexin with bilirubin was characterized by spectrophotometric, fluorimetric and circular dichroic techniques. Hemopexin rapidly forms an equimolar complex with libirubin that has an apparent dissociation constant Kd, of 7.5.10(-7) M. The association alters the absorption band of bilirubin near 150... | 620,056 | [
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Vasopressin release produced in anaesthetized cats by antagonists of gamma-aminobutyric acid and glycine. | 1 In cats anaesthetized with chloralose, the central excitatory substances, tubocurarine, picrotoxin, bicuculline, leptazol and strychnine, were applied to the exposed ventral surface of the brain stem through paired Perspex rings placed across the medulla and their effects on vasopressin release and arterial blood pre... | 620,101 | [
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Vulnerability and defensive reactions in relation to the human menstrual cycle. | The effects of alterations of the organism's internal state, attributable to the menstrual cycle, upon heart-rate responsivity and conditioning are reported. Two groups of 24 female phobic patients (one with natural cycles and the other taking the oral contraceptive) were tested, either premenstrually or intermenstrual... | 620,110 | [
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Clinical radionuclide perfusion lymphangiography. | In an initial pilot study technetium-99m-labelled human serum albumin was perfused directly into bipedal lymphatic cannulae prior to a standard lymphangiogram, in order to assess rapidly normal and abnormal lymph flow patterns in the lower extremity, pelvic and para-aortic lymph chains. A continuing study of these pati... | 620,117 | [
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Adrenocortical suppression in workers manufacturing synthetic glucocorticoids. | A man who had worked for 16 years in the manufacture of a potent corticosteroid was found to be suffering from chronic adrenocortical insufficiency attributed to chronic absorption of the glucocorticoid. Eleven other symptom-free workers were therefore screened. Two of these workers, like the first patient, gave grossl... | 620,203 | [
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Demonstration of nonspecific suppressor cells in the peripheral lymphocytes of cancer patients. | The response to phytohemagglutinin of peripheral blood lymphocytes was studied in 169 cancer patients. There was a significant decrease compared with control groups (normal persons and those with benign disease). By selecting cancer leukocyte samples with reactivity to phytohemagglutinin that was increased by carrageen... | 620,401 | [
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Determination of chromium sesquioxide in faeces by a spectrophotometric method. | Chromium sesquioxide Cr2O3, present as a non-absorbable marker in faeces, may be determined spectrophotometrically as chromate ion in aqueous solution after ashing and alkaline fusion. Recovery of this substance is excellent. The method described is simpler, more suited to the clinical laboratory and less hazardous tha... | 620,448 | [
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Electronic pipetting device for repetitive deliveries. | An automatic pipette for dispensing liquids is described. It is simple to operate and deliveries show a precision of 0.2% or better for volumes ranging between 2 and 50 ml, the dispensing rate depending upon pipette used. | 620,453 | [
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Cyproheptadine in levodopa-induced dyskinesia in parkinsonism. | The neuroendocrine properties and the beneficial effects of cyproheptadine in tardive dyskinesia led to the testing of this drug in levodopa-induced dyskinesia. Cyproheptadine administered to 6 parkinsonian patients in doses of up to 42 mg/day was of no significant benefit in either dyskinesia or symptom control. Impr... | 620,480 | [
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No circadian effect on nortriptyline kinetics in man. | Kinetics of a single 100-mg dose of nortriptyline were studied in 10 normal men who took this dose at 9 A.M. in the morning and on another occasion at 9 P.M. Only minimal differences in kinetic parameters were observed, none enough to be of any clinical consequence. A rather high first-pass metabolism of the drug was e... | 620,481 | [
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Pharmacokinetics of warfarin enantiomers: a search for intrasubject correlations. | The total body clearance of single doses of R(+)-, S(-)-, and racemic warfarin and the plasma concentration-anticoagulant effect curves for these drugs were determined in 10 healthy men, 21 to 51 yr old. This information was used to calculate the steady-state dose required to decrease prothrombin complex activity to ab... | 620,483 | [
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Bone blood flow and age in the rat. | 1. The proportion of the cardiac output delivered to the skeleton and individual bones has been determined in rats of differing ages and weights with radioactive microspheres. 2. There was a decrease in the blood flow to the tibia--fibula, jaw, femur, pelvis, humerus, radius and ulna, and scapula with increase in age a... | 620,488 | [
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Effect of isometric hand-grip exercise on the carotid sinus baroreceptor reflex in man. | 1. The changes in R--R heart interval that result from step-increase and step-decrease in carotid sinus transmural pressure induced by a variable pressure neck chamber were measured in seven normal men. Observations were made at rest, and during isometric hand-grip exercise at 24%, 44% and 64% of maximal voluntary cont... | 620,491 | [
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Anterograde and retrograde bradycardiac block in the His-Purkinje system. Finding in a patient with acute myocardial infarction. | A patient with an acute inferior myocardial infarction developed a complete atrioventricular block and intermitent periods of atrioventricular conduction with QRS complexes showing right bundle branch block associated with left anterior hemiblock. Recordings of the His bundle electrogram showed that the atrioventricula... | 620,543 | [
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Subarachnoid hemorrhage in children. | 45 cases of subarachnoid hemorrhage in children were surveyed. 73 percent of the causes were arteriovenous malformations and spontaneous intracerebral hematomata. Arteriovenous malformations in children may grow in size which may be due to the fact that besides the nidus demonstrated by angiography there are surroundin... | 620,619 | [
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The mitigating effect of dietary antioxidants on chemically-induced carcinogenesis. | The effect of a dietary antioxidant mixture on 3-methylcholanthrene mediated carcinogenesis in hairless mice was investigated. The antioxidant mixture significantly reduced the frequency of premalignant lesions and their subsequent development into tumors. The similarities in response of chemical and UV light-carcinoge... | 620,719 | [
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Microbiological transformation of biflavone. | Incubation of 5,5'-7,7'-tetramethoxy-8,8'-biflavone with Aspergillus niger results in the formation of 4,4'-dihydroxy-5,5'-7,7'-tetramethoxy-8,8'-biflavan. | 620,728 | [
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[Effect of adrenaline on rat atrial and ventricular chronoinotropy]. | The atria and ventricles were shown to differ from each other in: temporal course of contractions, relations between the strength of contractions and the interstimuli interval, resting potentiation, transitional processes after intermissions, character of response to adrenaline. For the first time the adrenaline was sh... | 620,858 | [
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[Compensatory-adaptive responses of the microcirculatory bed of rat mesentery in hypoxia]. | Television microscopy and stroboscopic determination of the blood flow speed showed that linear and volumetric speed of the blood flow in arterioles with gauge 40--20 mcm and venules with gauge 40--50 mcm diminished during repeated action of hypoxia and constrictory reaction. In capillaries and postcapillary venules wi... | 620,859 | [
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[Relationship between the frequencies of pacemaker and action potentials in the duodenal smooth muscle of dogs]. | In dogs with electrodes indwelled into the duodenum, four phases of the change of duodenum pacesetter potentials were revealed at rest in hunger whereas no such changes were observed during digestion. The frequency ranges of both the pacesetter potentials and the bursts of action potentials were wider in hunger than du... | 620,864 | [
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Yersinia enterocolitica as a cause of erythema nodosum. | 54 cases of erythema nodosum, seen in the Department of Dermatology at the St. Raphael University Hospital, Louvain, were reviewed for their possible aetiology. A search for Yersinia enterocolitica (Y.e.) agglutinins was performed in 21 patients of whom 8 had significant serum antibody titres. These cases are presented... | 620,866 | [
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Safety of cimetidine. | Our review of published material, manufacturer's files, and submissions to the United States Food and Drug Administration indicates that cimetidine is safe for short term use (up to 8 weeks). This judgment is based on a total experience with over 3000 patients. Clinically insignificant elevations of serum creatinine oc... | 620,916 | [
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[Developmental abnormalities of the gallbladder--two cases]. | Two cases of a psudoatresia of the gallbladder are referated. Only by intraoperative cholangiography the real situation could be shown. Without any exception this radiological method should be used in all operations of the biliary system. | 620,957 | [
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[Pupillary reflex dynamics studied with infrared pupillography]. | With a modified method of infrared pupillography--especially developed for the use in clinical neurological routine diagnosis--the time course of the direct phasic pupillary light reflex in man was investigated under physiological and pathological conditions. The described method allows a high resolution of the time co... | 620,958 | [
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Social institutions and economic decision making. | Perpetuating the present U.S. health care system, which spends more and more to produce about the same output, is irrational. Incentives that affect insurers and insureds, physicians, hospitals, and government are a necessity if a viable voluntary health care system is to survive. | 621,056 | [
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Health care amid religion and revelation. | Are hospitals places primarily of medicine or of religion? Can religion be hazardous to one's health? Is Christianity a religion? Is pastoral care of the center or at the margin of Catholic health care facilities? Discussion of these paradoxical questions is meant to facilitate some new understanding of "how Christian ... | 621,074 | [
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Prosthetic heart valves: which ones and why. | The type and to some extent the size of prosthesis are by far the most important factors determining the patient's prognosis. Extensive necropsy experience shows that in terms of hemodynamics, thrombogenesis, and deterioration-the three major criteria-none of the four main types of prosthetic valves in use today is ide... | 621,083 | [
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Genetic polymorphisms in juvenile-onset diabetes. | Nine genetic polymorphic systems (ACP1, PGM1, ADA, AK, G-6-PD, Hp, ABO, Rh, MN), were studied in a series of 138 subjects affected by JOD. Differences between diabetic patients and controls were observed in the distribution of phenotypes of the red cell acid phosphatase (ACP1), and the ABO and MN blood groups. | 621,091 | [
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Antimuscarinic effects of stereoisomers of tropicamide on rabbit iris sphincter. | The antimuscarinic activity of optical isomers of tropicamide were compared on the isolated rabbit iris sphincter. The increasing concentrations of both the (--)- and (+)-isomer shifted the dose-response curve of carbachol to the right in a parallel fashion. The competitive reversible muscarinic blocking effects of bot... | 621,129 | [
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In situ assay of poxvirus-induced and virion-contained deoxyribonucleases in DNA polyacrylamide gels. | Cowpox virus and vaccinia virus WR specific DNases were identified by an in situ assay using DNA-containing acrylamide gels. A DNase present in the isolated virions of strain cowpox and vaccinia WR was identified. Its properties as determined by the in situ assay resembled those of the well-characterized DNase V1. The ... | 621,135 | [
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Electron cytochemistry of developing and mature eosinophils in the bone marrow of the fowl and the duck. | Enzyme cytochemical studies have been carried out on eosinophils in the fowl and the duck. Peroxidase was found in all regions of the Golgi apparatus, the rough endoplasmic reticulum and the perinuclear cisternae of the early cells. In fowl eosinophil granules irregular deposits of peroxidase and arylsulphatase final r... | 621,162 | [
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Scanning electron microscopy of Gasterophilus intestinalis lesions of the equine stomach. | The lesions caused by larvae of Gasterophilus intestinalis in the cardiac region of the equine stomach were funnel-shaped ulcers surrounded by a rim of hyperplastic epithelial cells. Bacteria were commonly seen on the rim of epithelial cells, at the base of some ulcers, and within the cavities produced by the hooks of ... | 621,179 | [
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High pressure liquid chromatographic determination of methomyl and oxamyl on vegetable crops. | A reverse phase high pressure liquid chromatographic method is presented for the separation and determination of residues of the carbamates oxamyl and methomyl on vegetables. A liquid-liquid extraction and cleanup procedure is applied to the vegetable extract. Samples are eluted from a muBondapak C18 column and quantit... | 621,190 | [
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Quantitative determination of the binding of epsilon-aminocaproic acid to native plasminogen. | The binding of epsilon-amino[14C]caproic acid (6-aminohexanoic acid, EACA) to native human plasminogen was determined using the ultrafiltration technique of Paulus (Paulus, H. (1969) Anal. Biochem. 32, 91-100) at free ligand concentrations ranging from 2 micrometer to 16 mM. One strong binding site (Kd = 0.009 mM) and ... | 621,200 | [
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Assay of underivatized intrazepam and clonazepam in plasma by capillary gas chromatography applied to pharmacokinetic and bioavailability studies in humans. | The assay procedure of underivatized, intact nitrazepam and clonazepam in human plasma is described, using gas chromatography with a support-coated open tubular column (OV-17), a solid injection system and electron-capture detection. Clonazepam is used as a internal standard in the assay of nitrazepam and vice versa. L... | 621,234 | [
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Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation. | Secondary amyloidosis is a complication of diseases characterized by recurrent acute inflammation. In this study, a standardized stimulus which induced fever and inflammation was given to six normal subjects (19-24 yr old) to follow the fluctuation in concentration of serum amyloid A (SAA), the precursor of the seconda... | 621,279 | [
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Studies in porphyria. VII. Induction of uroporphyrinogen-I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes. | A 50% reduction in the activity of uroporphyrinogen-I (URO) synthase in liver, erythrocytes, and cultured skin fibroblasts characterizes all patients with clinically active acute intermittent porphyria (AIP). The same enzyme defect has also been demonstrated in the erythrocytes and skin fibroblasts of completely latent... | 621,286 | [
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Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis. | Growth was evaluated in a group of 10 infants and children with familial or idiopathic classic renal tubular acidosis in whom alkali therapy was initiated at ages ranging from 8 days to 9.5 yr and administered at dosage schedules documented to sustain correction of acidosis in at least four prolonged observation period... | 621,287 | [
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Categories of axons in the inferior cardiac nerve of the cat. | Myelinated and unmyelinated axons in the inferior cardiac nerve of the cat were examined to determine how many axons were (1) sensory, (2) preganglionic sympathetic, and (3) postganglionic sympathetic. In one group of cats, a segment was removed from the middle of the inferior cardiac nerve as a control, and the proxim... | 621,293 | [
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Prehospital and hospital coronary care. | This article reviews the current state of services for coronary care. Since the majority of deaths from coronary heart disease occur early and outside the hospital, the importance of the prehospital phase is emphasized. The delay in this period, which is very dangerous for the patient, should be reduced and mobile coro... | 621,316 | [
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Experimental intrinsic healing of flexor tendons based upon synovial fluid nutrition. | The healing process of totally cut and subsequently resutured rabbit flexor tendons kept isolated in the knee joint cavity and free in the synovial fluid was studied by histological and ultrastructural techniques. This experimental model represents a "tissue culture in situ," where the tendon is nourished by diffusion ... | 621,365 | [
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Personal observations on the role of the lumbrical muscles in carpal tunnel syndrome. | A case of carpal tunnel syndrome is presented in which an abnormally high origin of a lumbrical muscle seemed to be the cause. Since the patient and author are the same, the symptoms of compression and during the postoperative period are well documented. Evoking the symptoms by exercise or active motion is suggested fo... | 621,370 | [
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Single radial haemolysis: a survey of antibody titres in the highland region of Scotland to recent strains of influenza A. | The single radial haemolysis test is conveniently practical and economical and promises to have wide applicability in the study of influenza antibodies in human populations. It can also be adapted for preliminary examination of new virus isolates during epidemics. Using this test a rather higher proportion of the popul... | 621,377 | [
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Field trials of WBA 8119 (PP 581, brodifacoum) against warfarin-resistant infestations of Rattus norvegicus. | Baiting with medium oatmeal or soaked wheat containing 0.002, 0.001 or 0.0005% brodifacoum completely controlled infestations of warfarin-resistant rats on farms when the poisoned baits were maintained until rats ceased to feed on them. The concentration of brodifacoum did not affect the duration of these treatments wh... | 621,382 | [
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Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens. | By indirect immunofluorescence and microcytotoxicity it was demonstrated that different populations of murine macrophages bear different amounts of Ia antigens on their membranes. At least three subpopulations could be distinguished: those that lack Ia antigens and predominate in peritoneal exudate; cells bearing I-A a... | 621,385 | [
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A comparison of procedures to determine free fatty acids in rat heart. | The level of free fatty acids in intact tissues has been found to be low but is known to rise in proportion to the extent of autolysis. Therefore, the high levels of free fatty acid reported in the cardiac lipids of rats fed rapeseed oil were reinvestigated using two different procedures for homogenization. Quick freez... | 621,434 | [
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Active cables for use with dry electrodes for electrocardiography. | With the active cables described in this paper, it is possible to record the electrocardiogram with dry electrodes. Simultaneous recordings of the ECG from dry electrodes via the active cables and from conventional electrodes with electrode paste demonstrate that there is no discernible difference in the electrocardiog... | 621,458 | [
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The Rescorla-Wagner model: losses in associative strength in compound conditioned stimuli. | This series of experiments demonstrated that compound conditioned stimuli (CSs) highly conditioned in isolation lose conditioned response strength when compound-CS-unconditioned stimulus (US) pairings are given. This loss in conditioned responding was a positive function of the number of compound-CS-US pairings and was... | 621,465 | [
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Accumulation and localization of gallium-67 in various types of primary lung carcinoma. | The uptake and location of Ga-67 were investigated in 15 primary pulmonary carcinomas. The accumulation in the tumor was determined by scintigraphy of the patient, grain counts over fields of tumor cells in autoradiographs of tumor-tissue samples, and gamma counts in specimens of the tumor. Good correlation was found b... | 621,559 | [
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Studies on the role of nickel in the ruminant. | Lambs were fed 6 to 7% of metabolic body weight per day of a basal purified diet low in nickel (65 ppb) or the basal diet plus 5 ppm nickel for a 97 day period in an attempt to demonstrate an essential role for nickel in the ovine. Weight gains for the entire period and digestibility of dry matter and of protein at 28 ... | 621,585 | [
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Alterations of rat adipose tissue metabolism associated with dietary chromium supplementation. | Net free fatty acid release from adipose tissue taken from male rats fed a stock diet unsupplemented with chromium was significantly greater than that from adipose tissue taken from chromium-supplemented rats. This enhanced net lipolysis was unaccompanied by any evidence of a compensatory increase in reesterification. ... | 621,586 | [
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Differences in pulmonary function tests among whites, blacks, and American Indians in a textile company. | Normal standards for pulmonary function in nonwhite populations are not presently available to occupational health workers. The present study examined differences in %FVC, FVC, FEV1/FVC, FEF 200-1200 and FEF 25-75% among whites, blacks, and American Indians. The sample consisted of 4209 job applicants to a textile comp... | 621,593 | [
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Localization of the site of urinary tract infections by means of antibody-coated bacteria in the urinary sediments. | A prospective study was conducted in children with urinary tract infections to examine the relationship between the presence of antibody-coated bacteria in the urinary sediments and the presence of pyelonephritis. The site of the urinary tract infection was localized as upper or lower urinary tract by the bladder washo... | 621,601 | [
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Modification of a screening program for neonatal hypothyroidism. | From our experience in the screening of 212,000 newborn infants, we have devised a flow chart for processing T4 and TSH measurements obtained from initial filter paper blood spots. To date, all infants with thyroid dysfunction or TBG deficiency have been detected. Of the population screened, 1.84% require a spot TSH de... | 621,609 | [
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Kinetics of plasma coagulation and lysis I: Basic kinetic model for time course of coagulation-lysis systems and its potential application to clinical studies. | The time courses of coagulation and coagulation-lysis were spectrophotometrically monitored after the addition of thrombin or thrombin-streptokinase to plasma, diluted 1:5 with normal saline, obtained from normal and presumably abnormal subjects. The kinetics of clotting, after an initial lag period of 0.5-1.5 min, dem... | 621,627 | [
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Fenoprofen: drug form selection and preformulation stability studies. | Several fenoprofen salts were prepared to obtain the most acceptable form for an oral dosage formulation. Thermal analysis techniques were used to compare stabilities of the water of hydration in different salt forms and to assess the effects of the water of hydration on compatibility with propoxyphene and codeine salt... | 621,644 | [
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Validity of oral bioavailability estimates of phenolsulfonphthalein based on total urinary excretion from rats. | Urinary recovery of phenolsulfonphthalein from rats were determined after intracardial (0.075 mg) and oral (1.5 mg) doses. Although trace quantities of conjugated metabolites could be identified by TLC, the levels present did not introduce significant error into estimates of total phenolsulfonphthalein excretion if sam... | 621,654 | [
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Differential borohydride assay for conjugated ketosteroids: improvement with propylene glycol. | A previously developed differential UV assay for 3-one-4-ene steroids involving reduction with sodium borohydride was frequently found to be less than 100% complete. Such incomplete reduction can be mimicked by additions of sodium metaborate, a product of the hydrolysis of sodium borohydride, to the reaction system. Co... | 621,657 | [
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Relationship between sperm concentration and the incidence of polyspermy in mouse embryos fertilized in vitro. | A dose-response relationship between the incidence of polyspermy and sperm concentration was found by analysing chromosome preparations of first-cleavage mouse embryos derived from fertilizations in vitro with 3 concentrations of mouse spermatozoa (2 x 10(4), 2 x 10(6) and 1 x 10(7)/ml). | 621,682 | [
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Prostaglandin concentrations in the semen of fertile men. | The PG concentrations in the semen of 23 fertile men were 73 microgram PGE/ml, 267 microgram 19-OH PGE/ml, 2.1 microgram PGF/ml and 18.3 microgram 19-OH PGF/ml. The wide ranges of concentrations found for the PGEs (2-272 microgram/ml) and for the 19-OH PGEs (53-1094 microgram/ml) throw some doubt on the previously esta... | 621,688 | [
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Methyl 6-(phenylsulfinyl)imidazo[1,2-a]pyridine-2-carbamate, a potent, new anthelmintic. | A series of methyl imidazo-[11,2-a]pyridine-2-carbamates was synthesized for anthelmintic testing. The preparation of this class of compounds was simplified by utilization of a novel one-step condensation of the appropriately substituted 2-aminopyridine and methyl chloroacetylcarbamate. The most potent compound, methyl... | 621,722 | [
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Proliferative changes in the epithelium of the human lithiasic gallabladder. | Surgical specimens from 9 normal human gallbladders and from 9 lithiasic gallbladders were incubated in vitro with [3H]thymidine. Autoradiography was used to observe the cells in DNA synthesis in the mucosal epithelium. The percentages of labeled cells (labeling index) and of mitotic figures (mitotic index) were estima... | 621,747 | [
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Higher antitumor efficacy of daunomycin when linked to dextran: in vivo and in vitro studies. | Daunomycin was coupled to dextrans of various molecular sizes. The binding to the dextran carriers augmented the therapeutic efficacy of the antitumor agent in a murine lymphoma line (YAC). When the treatment with the drug or its conjugates was given concomitantly with the tumor cells at separate sites, the unbound dru... | 621,754 | [
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Chip fracture through the superior articular facet with compressive cervical radiculopathy. | Four patients with cervical radiculopathy secondary to a chip fracture through the superior articular facet have been treated in the past 2 years. These small-element fractures may occasionally pass unrecognized. Although oblique X-rays are helpful, lateral tomography has provided the most precise detail. The pathologi... | 621,768 | [
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Pulmonary edema in cervical spinal cord injury. | A 15-year-old patient with acute cervical spine injury (C5) and pulmonary edema is presented. There was no craniocerebral injury. Causes other than the injury are excluded. Acute cervical spine injury appears to be another cause of noncardiogenic pulmonary edema. | 621,770 | [
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Intracellular synthesis of measles virus-specified polypeptides. | The intracellular synthesis of measles-specified polypeptides was examined by means of polyacrylamide gel electrophoresis of cell extracts. Since measles virus does not efficiently shut off host-cell protein synthesis, high multiplicities of infection were used to enable viral polypeptides to be detected against the hi... | 621,777 | [
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Procedure for purification of intact DNA from vaccinia virus. | A procedure for the isolation of intact vaccinia DNA molecules by chromatography on hydroxyapatite in the presence of 6 M urea is described. When lysates of virions containing 0.5 to 10 microgram of DNA were employed, over 95% of the viral DNA could be recovered free of poteins. Vaccinia DNA molecules isolated in this ... | 621,785 | [
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Effect of protein synthesis inhibitors on viral mRNA's synthesized early in adenovirus type 2 infection. | Viral mRNA species synthesized early in adenovirus type 2 infection in the presence of cycloheximide were compared with those synthesized in the absence of drug or in the presence of the DNA synthesis inhibitor 1-beta-D-arabinofuranosylcytosine. Cycloheximide caused approximately a 10-fold stimulation in the accumulati... | 621,786 | [
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Aspermia owing to obstruction of distal ejaculatory duct and treatment by transurethral resection. | A case of a young aspermic male patient with bilateral atresia of the terminal ejaculatory duct is reported. He was treated successfully by transurethral resection of the prostate gland in the area of the ejaculatory ducts. | 621,800 | [
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Isotope loopography, a new test: comparison with standard loopography and its relationship to renal function in patients with ileal conduit urinary diversion. | Reflux associated with the classic ileal conduit has been implicated as possibly contributing to long-term renal deterioration. When demonstrated on a standard loopogram reflux occurs under highly non-physiologic conditions. A new method of radioisotope loopography performed under physiologic conditions was devised and... | 621,807 | [
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0.2833479,
-0.144563,
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0.1831396,
0.101807,
0.1769262,
... |
Segmental resection in the management of bladder carcinoma. | Segmental resection for bladder carcinoma was performed on 144 patients at our medical center between 1945 and 1971. Of these 144 cases 101 had sufficient documentation to provide meaningful data for a retrospective study. The 5-year survival rates for patients with invasive bladder carcinoma, expressed as a function o... | 621,816 | [
-0.02911438,
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Delayed hemolytic transfusion reactions. An often-missed entity. | Delayed hemolytic transfusion reactions in eight persons were manifested solely or primarily by an apparently unexplained posttransfusion decrease in the hematocrit value. Alloantibodies were eventually found in all eight patients, but were sometimes undetectable for as long as 72 hours after the reaction. This did not... | 621,892 | [
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0.4229674,
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0.1... |
Platelet aggregation. Adult-onset diabetes mellitus and coronary artery disease. | Using a turbidimetric technique, we determined 1.7 micrometer adenosine diphosphate--induced platelet aggregation and disaggregation at 37 degrees C in the platelet-rich plasmas of two groups of men with coronary artery disease. Eleven men were nondiabetic and 11 had adult-onset diabetes mellitus without retinopathy. T... | 621,893 | [
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0.09389798,
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[Effect of space flight and of the accompanying radiation on amino acid metabolism in the skeletal muscle of rats]. | It was demonstrated that a combined effect of 20.5-day space flight and gamma-irradiation reduced the content of biologically important amino acids (methionine, phenylalanine, serine, aspartic and glutamic acids) and inhibited the activity of aspartate aminotransferase of sarcoplasmatic proteins in the quadriceps muscl... | 621,908 | [
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0.1066468,
0.1378599... |
Primary care treatment of emotional problems in an HMO. | Integrating mental health services into primary care should improve the availability, access, and delivery of psychiatric care to the whole population. Health maintenance organizations (HMOs) are settings for the development of integrated medical-mental health services. This paper reports findings of a project to evalu... | 621,976 | [
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Increase in plasma extracellular fluid volume ratio caused by bilateral nephrectomy in patients on maintenance hemodialysis. | Changes, observed in rats after bilateral nephrectomy, in blood pressure and in the relation betwen plasma volume-extracellular fluid volume or plasma volume-interstitial fluid volume, are consistent with the postulation that the kidney secretes a substance that regulates, to some degree, the compliance of the intersti... | 622,212 | [
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0.2708226,
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... |
Endodermal sinus tumor of the ovary. The orphan tumor. | The endodermal sinus tumor of the ovary is a rare and highly lethal germ cell tumor. At least 10 different names have been applied to it, and so long as its name remains unsettled the collection of information will continue to be greatly impeded. One of the patients who came under our observation died after 21 months d... | 622,238 | [
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0.06364292,
0.1376445,
0.0812349,
-0.19... |
[Ultrastructure of the midgut in Ornithodoros papillipes (Acarina, Argasidae) nymphs in the blood assimilation period]. | Three types of cells (reserve, digestive and secretory) differing in their ultrastructural characters were found to exist in the epithelium of the midgut of nymphs of O. papillipes during the blood assimilation. Reserve and secretory cells are dominant at the first stage of digestion while digestive cells are most abun... | 622,293 | [
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0... |
[Epizootiological importance of Frontopsylla hetera (Siphonaptera) fleas in the Gorno-Altai natural plague focus]. | Experiments conducted during all seasons have established that F. hetera, one of the mass species of fleas in Mountain Altai, can be infected both by the strain of selective virulence typical to this nidus and by the non-typical non-virulent mountain-altai strain of plague agent. The non-virulent strain does not form i... | 622,294 | [
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0.3389673,
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0.264988,
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Frequency of occurrence of the transversus menti muscle. | The transversus menti muscle was present in 9 of 16 cadaver specimens. The anatomy and the frequency of this muscle are discussed, as is the possibility of its clinical use in the reconstruction of defects around the angle of the mouth in selected patients. | 622,414 | [
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0.0321362,
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0.5236837,
0.1967197,
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Errors in reporting cancer and other conditions by persons in a prospective study. | The hospital records of 553 men were compared with their medical histories obtained by interviews after hospitalization. Forty men had documentation of cancer in their hospital records stated that they had the specific condition. However, 21 other cancer patients did not give a positive history of their documented dise... | 622,442 | [
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0.03866055,
0.3357314,
0.01368677,
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0.2828982,
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0.029136... |
Jerman Memorial Lecture. Scanning a new image: proposal for professional standards. | An analysis of trends in radiologic technology in other countries of the world is compared with current standards of education and socioeconomic practices in America. From this background, radiologic technologists are challenged to reassess their position in American health care and forge new directions to make radiolo... | 622,465 | [
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0.06477376,
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0.06006518,
0.02456228,
0.1163447,
0.1754648,
-0.09037629,... |
Radiographic findings in the hands in patients with systemic lupus erythematosus. | Hand radiographs of 59 patients with systemic lupus erythematosus (SLE) were examined. Thirty-four revealed radiographic abnormalities, most commonly periarticular soft-tissue swelling or demineralization. Alignment abnormalities, acral sclerosis, avascular necrosis, soft-tissue calcification and terminal tuft resorpti... | 622,474 | [
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0.08470149,
0.130292,
0.08467396,
0.3069803,
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... |
Histiocytic medullary reticulosis in childhood. | The clinical, radiographic and pathologic findings of two children (ages 6 months and 5 1/2 years) with histiocytic medullary reticulosis are reviewed. Chest radiographs, excretory urograms, and skeletal survey revealed involvement of the mediastinum, lung parenchyma, pleural space, liver, spleen, kidneys, retroperiton... | 622,499 | [
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-0.3317635,
0.01477678,
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0.07633539,
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0.2455668,
0.1799185,
0.1567322,
... |
Therapeutic embolization with detachable balloons. Physical factors influencing permanent occlusion. | Twenty-one detachable Silastic 3 balloon embolizations were performed in 12 swine. Late balloon rupture was associated in vivo with increased size and decreased radiopacity of the balloons. Variables affecting the permanency of occlusion by the Silastic balloons were the osmolarity of the contrast medium and the size ... | 622,506 | [
0.05891185,
0.2221622,
0.1377862,
0.1521559,
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0.05913478,
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-0... |
Influence of pulmonary hypertension on pulmonary diffusing capacity in patients with mitral stenosis. | The pulmonary diffusing capacity (DLCO--steady state method according to Bates and coworkers) was measured at the time of heart catheterization in 12 patients with mitral stenosis without mitral incompetence. DLCO correlates with the tidal volume at rest and during exercise and with pulmonary vascular resistance during... | 622,513 | [
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0.09023292,
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0.1376034,
0.008072327,
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0.10984... |
Sputum eosinophilia in chronic bronchitis and asthma. | The occurrence of sputum eosinophilia was investigated in 115 patients with chronic bronchitis and asthma. They were clinically divided into four groups; those with asthma only, those with asthma of equal or greater duration than chronic bronchitis, those with chronic bronchitis recently complicated by asthma and those... | 622,522 | [
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-0.09811018,
0.2778656,
-0.1083501,
0.1293679,
0.2171205,
0.09189203,
0.0909... |
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