title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[D-xylose absorption test. A pharmacokinetic and statistical study]. | D-xylose pharmacokinetics has been studied in 6 healthy subjects by serial measurement of blood and urinary levels following oral and intravenous administration of two doses of D-xylose (5 and 25 g successively). Furthermore, patients with obesity, renal or hepatic insufficiency, or with a T-drain after cholecystectomy... | 622,549 | [
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Durations of unitary synaptic potentials help time a behavioral sequence. | Recordings in identified neurons and muscles that mediate crayfish tailflips reveal inhibitory postsynaptic potentials of two distinct durations. Those of long duration are recorded in five classes of cells in the flexion circuit, while those of short duration are recorded in three classes of cells in the extension cir... | 622,557 | [
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Pelvic displacement osteotomy in young myelodysplastic patients with dislocatable hips. | This prospective study of the role that pelvic displacement osteotomy may have in the management of dislocatable hips in patients with myelomeningocele defines the technical points to be considered and gives preliminary results for ten hips in eight children. The procedure may salvage failed posterior iliopsoas transfe... | 622,595 | [
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Role of sodium intake in the antihypertensive effect of propranolol. | Twelve hypertensive patients had measurements of body weight, blood pressure, plasma renin activity, and plasma volume during periods of normal sodium intake and acute sodium depletion. After receiving propranolol orally for four to 14 weeks, repeat measurements were obtained under identical conditions of sodium intake... | 622,601 | [
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Bronchial carcinoids and hormonal disorder. | The relationship between bronchial carcinoids and hormonal disorder is reviewed in the light of a study of 24 patients with carcinoid tumors of the bronchus. In this series, two patients presented with manifestations of the polyendocrine disorder. The common origin of carcinoid tumors and other APUD cells from neural c... | 622,615 | [
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Bronchoscopy in the community hospital. | A new Pulmonary Medicine-Thoracic Surgery service was established in a community hospital in July 1974. This report details the experience of 409 bronchoscopies performed from July 1, 1974 through Dec 31, 1976. There were no deaths and four complications--one aspiration and three pneumothoraces resulting from transbron... | 622,619 | [
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Gastroscopy in surgical practice. | We reviewed the records of 100 consecutive patients who had gastroscopy. All endoscopic work was done by our four-man surgical group. Roentgenographic and endoscopic diagnoses are compared with reference to degree of accuracy. The expanded uses of gastroscopy in surgical practice are illustrated and a plea is made for ... | 622,620 | [
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Angiography of the pancreas. | The diagnostic potentials of pancreatic angiography are discussed on the basis of four illustrative cases and a review of the pertinent literature. It is concluded that selective visceral angiography properly applied is of great value in diagnosing carcinoma of the pancreas and in determining resectability of pancreati... | 622,628 | [
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Surgical experience with craniopharyngioma in adults. | It is proposed that the term craniopharyngioma of the adult be employed only for tumors presenting after the successful completion of puberty. The contrasts with the current practice of arbitrary distinction on the basis of age at the time of operation. Of 48 patients over 20 years of age at the time of operation, 38 f... | 622,676 | [
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[Autologous blood donation and transfusion in cardiosurgical high risk patients (author's transl)]. | In an unselected group of patients undergoing a wide variety of cardiovascular operations, the possibilities of long-term preoperative autologous blood collection combined with oxygenator hemodilution were examined. The mean number of preoperative donations was 2.5 units of blood. It was 50 p.c. higher in men than in w... | 622,718 | [
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Intracranial hemorrhage and infarction in anticoagulated patients with prosthetic heart valves. | In 1 year 6 patients with prosthetic heart valves (PHVs) treated with anticoagulants suffered intracranial hemorrhage. In 4, hemorrhage occurred into the site of a recent non-hemorrhagic infarction. In the others, both of whom had endocarditis, hemorrhages probably occurred as the result of rupture of a mycotic aneurys... | 622,739 | [
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Torsion of spermatic cord. | A series of 198 cases of acute unilateral, painful scrotal swelling considered to be torsion is presented and an aggressive surgical management of this entity described. The results achieved, a high incidence of testicular salvage, justify this aggressive approach. | 622,758 | [
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Detection of bone metastases in urogenital malignancies utilizing 99mTc-labeled phosphate compounds. | A retrospective study of 99 patients with proved urogenital malignancies was done to determine the value of bone scanning versus roentgenographic skeletal survey in assessing the degree of metastatic involvement. Findings on bone scans were positive in 59 patients, and in 7 of these patients results of roentgenographic... | 622,775 | [
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[Cardiac function diagnosis in the hemodialysis practice using so-called Rentsch tension index]. | The so-called tension index PI after Rentsch allows a frequently repeatable control of the degree of sufficiency of the heart with slight annoyance of the patient and moderate expenditure of time. In dialysis patients in whom the heart stress and the conditions of the interior milieu frequency acutely change with the h... | 622,842 | [
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Regression of tumour growth after administration of alkoxyglycerols. | A regression of tumour growth is observed when alkoxyglycerols are administered prior to radiation treatment of patient suffering from cancer of the uterine cervix. This regression has been demonstrated by a change in the quotient between the incidence of early and advanced stages. | 622,894 | [
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Blunt and penetrating chest trauma. | Blunt or penetrating trauma to the chest can cause several life-threatening conditions: open or closed pneumothorax, each with or without hemothorax; flail chest; pericardial tamponade, and injury to other structures in the chest--the esophagus, trachea or great vessels. Any trauma sufficient to compromise function of ... | 622,937 | [
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The role of the central nervous system in chronic congestive heart failure. | Even though congestive heart failure is extremely common, the mechanisms responsible for the clinical manifestations remain a puzzle. The central and autonomic (sympathetic) nervous systems are responsible for a large part of the clinical manifestations. The role of the nervous system in CHF is discussed briefly. It is... | 622,960 | [
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Creatine phosphokinase MB isoenzyme in hypothermia: case reports and experimental studies. | Six patients with severe medical disorders and profound hypothermia are presented who had elevated total serum creatine phosphokinase (CPK) and CPK-MB isoenzyme activity without clinical or postmortem evidence of acute myocardial infarction. Experiments in dogs indicate that hypothermia reduces total CPK activity in bo... | 622,978 | [
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Valve origin of the aortic incisura. | The occurrence and magnitude of the incisura of the central aortic pressure were shown in 66 patients to depend on the functional state of the aortic valve. In normal subjects and children with congenital aortic stenosis (with thin flexible leaflets), the incisura ranged between 6 and 14 mm Hg. With aortic regurgitatio... | 623,003 | [
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Apoenzyme activities of erythrocyte transketolase, glutathione reductase, and glutamic-pyruvic transaminase during pregnancy. | The erythrocyte apoenzyme activities of transketolase, glutathione reductase, and glutamic-pyruvic transaminase were determined in 236 pregnant women during the first or second trimester and again during the third trimester. There were no differences in erythrocyte glutathione reductase and erythrocyte glutamic-pyruvic... | 623,040 | [
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Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication. | A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate. Three of the seven patients were given a dosage of medication ... | 623,061 | [
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Tick-borne relapsing fever in the Eastern United States. | Tick-borne relapsing fever is endemic in the western part of the United States, but it has not been reported east of the Mississippi River. Sporadic cases have been reported in the eastern part of the United States, but travel to the West during the incubation period appeared to provide the source of infection. In the ... | 623,062 | [
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Hypogastrinemia in hypothyroidism. | Fasting plasma gastrin levels measured by radoimmunoassay were found to be low in patients with hypothyroidism. The intravenous infection of arginine caused an increase of plasma gastrin in hypothyroid patients but was significantly lower than those in normal subjects. The decreased gastrin level in patients with hypot... | 623,084 | [
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Raw hamburger: an interstate common source of human salmonellosis. | An interstate common-source outbreak of salmonellosis was first detected in the United States in September and October, 1975, when a tenfold increase in Salmonella newport isolates was noted through routine salmonella surveillance by the Colorado Department of Health. Eighteen primary cases with a distinctive antibioti... | 623,088 | [
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Purification and substrate specificity of polymorphic forms of esterase D from human erythrocytes. | Esterase D (EsD), purified from human erythrocytes and tested with a variety of substrates, hydrolyzed only triacetin, tributyrin, and certain soluble aryl esters of aliphatic acids. Esters of 4-methylumbelliferone were easily the best substrates. When the three genetically different isozymes were compared, the less co... | 623,100 | [
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Efficiency and robustness of pedigree segregation analysis. | Different pedigree structures and likelihoods are examined to determine their efficiency for parameter estimation under one-locus models. For the cases simulated, family size has little effect; estimates based on unconditional likelihoods are generally more efficient than those based on conditional likelihoods. The pro... | 623,101 | [
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The genetics of Otosclerosis. I. Distorted sex ratio. | The offspring of 214 otosclerotic x normal couples were investigated, and within these sibships, the segregation of otosclerosis is compatible with autosomal dominant inheritance. However, the overall sex ratio is approximately 0.73, with otosclerosis being approximately 1.8 times more frequent in female offspring. The... | 623,103 | [
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Drug use review: operational definitions. | A distinction is made between drug use review (DUR) studies and programs. DUR studies can be quantitative or qualitative. Quantitative studies involve the collection, organization and display of estimates or measurements of amounts of drug use. Qaulitative studies are multidisciplinary operations which collect, organiz... | 623,123 | [
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Immediate and delayed reward preferences of TMR adolescents. | Adolescent TMR students (mean IQ = 37) were presented with a list of 32 reward options, consisting of primary (food) and secondary (cash equivalent) rewards that were immediately available or delayed one day at a ratio of 1:2. The greatest number of delay choices occurred when the decision was between immediate/seconda... | 623,161 | [
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Pigment epithelial proliferation in human retinal detachment with massive periretinal proliferation. | Biopsy specimens from vitreous and preretinal membranes, obtained during vitreous surgery from 39 human eyes suffering from massive periretinal proliferation, were examined electron-microscopically. Analysis of the cellular membranes demonstrated mostly cells with epithelial characteristics: polarization of the cells, ... | 623,188 | [
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Studies of calcium-45 desaturation from kidney slices in flow-through chambers. | This paper describes a method to measure calcium fluxes and calcium exchangeable pools in tissue slices by continuous perifusion in flow-through chambers. 45Ca desaturation from rat kidney slices can be analyzed as in an open three-compartment catenary system. A set of equations is given to calculate all the relevant k... | 623,283 | [
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Renal and adrenal responses to [des-Asp1]angiotensin I in the dog. | There is evidence for the endogenous generation of [des-Asp1]angiotensin II (AIII) from a nonapeptide precursor, [des-Asp1]angiotensin I ([des-Asp1]AI). In the present study, the effects of equipressor doses of exogeneously administered [des-Asp1]AI and AIII on renal function and plasma aldosterone concentration were c... | 623,303 | [
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Heart rate response to isocapnic hypoxia in conscious man. | We studied the effect of acute progressive hypoxia on heart rate in conscious healthy subjects. The PCO2 was held constant (+/- 1.5 mmHg) midway between the resting end-tidal and mixed-venous levels. Hypoxia was induced by having the subject rebreathe from a small bag so that the PO2 fell at a rate related to the subje... | 623,312 | [
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Organic impairment in polydrug users: risk factors. | In a national collaborative study to assess the neuropsychological status of 151 polydrug users, the Halstead-Reitan Neuropsychological Battery showed deficits in 37% two to three weeks after they entered treatment and in 34% at three-month follow-up. Comparative rates for a group of psychiatric patients were 26% and 2... | 623,328 | [
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Psychiatric consultation in a Vietnamese refugee camp. | The authors provided psychiatric consultation to medical personnel in charge of a Vietnamese refugee camp in California. Although the emergency measures that supplied clothing, food, shelter, and medical care to nearly 60,000 refugees were immensely successful, consultation was requested to assist with selected mental ... | 623,329 | [
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Eye blink and schizophrenia: psychosis or tardive dyskinesia? | The author found abnormalities of ocular movement including abnormal blink rate and blink reflex to glabellar tap in 34 of 44 medication-free schizophrenic patients. It is not clear whether these signs represent part of the pathology of schizophrenia or result from withdrawal of neuroleptic treatment. | 623,338 | [
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Community medicine in the British National Health Service. | Reorganization of the British National Health Service in April 1974 brought about the creation of Community Medicine as a service specialty. Development of thinking on the type of role British community medicine should play is briefly described. The functions of the community medicine specialist at the different tiers ... | 623,362 | [
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The effect of feeding on the bile salt-independent canalicular secretion in dogs. | Mongrel dogs were prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of cannulas into the duodenum and stomach. During experiments on the unanesthetized dogs, bile was collected by cannulating the common bile duct through the duodenal cannula. Canalicular secretion was estimated by the b... | 623,371 | [
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Critical look at the classification of maxillary sinus carcinomata. | All the classification systems at present adopted for use in carcinoma of the maxillary sinus suffer from both intrinsic inaccuracies and an apparent failure to relate T (extent of primary tumor) categories to clinical experience of the spread of these tumors. Three systems are critically analyzed in relation to person... | 623,416 | [
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[Development of a method for the quantitative assessment of microorganism sensitivity to antibiotics using discs. The study of different nutrient media for determining microorganism sensitivity to antibiotics]. | Five nutrient media used for determination of microbial sensitivity to antibiotics, i.e. beaf-peptone agar, Hottinger pancreatic beaf infusion agar, sprat hydrolysate nutrient agar of the Dagestan Research Institute of Nutrient Media, Muller-Chintone agar from Bulgaria and "Oxoid" agar for determination of microbial se... | 623,447 | [
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Analysis of bacterial fermentation products by isotachophoresis. | Various carboxylic acids from bacterial fermentation could easily be separated by isotachophoresis. The analyses were performed on an LKB 2127 Tachophor, and under the conditions used the minimum amount of sample that could be quantitatively estimated was approximately 0.1 nmol. The reproducibility of the method was go... | 623,461 | [
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Dulcitol-malonate-phenylalanine agar for the identification of Salmonella and other Enterobacteriaceae. | An agar medium combining dulcitol fermentation, malonate utilization, and phenylalanine deamination was evaluated with 229 isolates representing 19 genera. All reactions agreed with those obtained on conventional media. | 623,462 | [
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Phototrophic purple and green bacteria in a sewage treatment plant. | In all purification stages of a biological sewage treatment plant, phototrophic bacteria were detected by the method of viable cell counts. The predominant species identified belonged to the genus Rhodopseudomonas of purple nonsulfur bacteria. The number of phototrophic bacteria was highest in wastewater containing slu... | 623,470 | [
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Distribution of autotrophic nitrifying bacteria in a polluted river (the Passaic). | The abundance of nitrifying bacteria, determined by most-probable-number procedures, within habitats of the Passaic River was as follows: rooted aquatic plants greater than algae approximately equal to rocks greater than sediments greater than greater than water. On the average, NH4+ oxidizers were 540-fold more abunda... | 623,474 | [
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Compact liquid nitrogen storage system yielding high recoveries of gram-negative anaerobes. | A simple and compact system suitable for the preservation of fragile gram negative anaerobes and other bacteria in liquid N2 has been developed. Polypropylene straws used as specimen containers can be used easily within glove bags of anaerobic chambers, and their small size greatly increases the number of cultures whic... | 623,475 | [
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Lithium carbonate and brain function. I. Cerebral-evoked potentials, EEG, and symptom changes during lithium carbonate treatment. | Eighteen patients were studied with behavioral ratings and the somatosensory (SER), auditory (AER), and visual (VER) cerebral-evoked response and quantified EEG before and during lithium carbonate treatment. The amplitude of early positive SER components and most AER components increased during treatment, but VER did n... | 623,509 | [
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Surgical repair of prolapsed lacrimal glands. | Herniation of the lacrimal gland is a condition that occurs unilaterally or bilaterally. Either or both lobes of the lacrimal gland may prolapse. Orbital lobe prolapse may be associated with blepharochalasis, a disease of puberty. We developed a surgical technique for the repair of prolapsed lacrimal glands. It is impo... | 623,540 | [
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Evaluation of drugs in ointment for mydriasis and cycloplegia. | Ointment preparations of cyclopentolate hydrochloride and tropicamide were compared with aqueous drops of these medications for the production of mydriasis and/or cycloplegia in clinic patients. Mydriasis and/or cycloplegia could be accomplished by the single application of a minute volume (around 0.005 ml) of ointment... | 623,548 | [
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... |
Increased secretion of growth hormone, prolactin, antidiuretic hormone, and cortisol induced by the stress of motion sickness. | The stress of motion sickness was experimentally provoked by Coriolis effect. Significant and reproducible increases from the basal serum level (delta mean +/- S.E.) of antidiuretic hormone delta - ADH: 48.2 +/- 4.6 pg/ml; p less than 0.0005), of growth hormone (delta - hGH: 10.0 +/- 1.2 ng/ml; p less than 0.0005), of ... | 623,565 | [
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Increased urinary excretion of triiodothyronine (T3) and thyroxine (T4) and decreased serum thyreotropic hormone (TSH) induced by motion sickness. | We exposed 35 male subjects to a rotary chair and motion sickness was provoked by Coriolis effect. This stress caused an increased excretion of urinary T3 and T4 and a decrease of TSH levels in serum. The increment in urinary excretion of thyroid hormones may serve as a very useful measure for the quantitation of physi... | 623,566 | [
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Migrainous phenomena in systemic lupus erythematosus. | Eleven patients with systemic lupus erythematosus (SLE) also had headaches and/or visual hallucinations typical of those found in migraine. These migrainous symptoms were commonly associated with exacerbations of SLE and abated as disease activity subsided. In some cases corticosteroids were more effective than convent... | 623,696 | [
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Abnormal platelet function in pre-eclampsia. | Platelet behaviour was studied in groups of women suffering from mild and severe pre-eclampsia, and compared with normal pregnant and non-pregnant controls. Platelets from women with severe pre-eclampsia were less responsive than normal to a variety of aggregating agents, and this impairment was significant in response... | 623,722 | [
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Platelet lifespan in normal pregnancy as determined by a nonradioisotopic technique. | A nonradioisotopic technique for determination of platelet lifespan was applied to 19 healthy women whose gestational ages were between 32 and 40 weeks. Nine non-pregnant women and five men were also studied. Platelet counts were performed in all subjects. No significant difference was demonstrated between platelet lif... | 623,723 | [
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Diversity and abundance of polyadenylated RNA from Achlya ambisexualis. | The diversity, abundance, and DNA sequence representation of poly(adenylic acid) containing RNA derived from cells of Achlya ambisexualis cultured in defined and undefined media have been determined. The kinetics of hybridization of polyadenylated RNA with complementary DNA were the same for both culture conditions and... | 623,740 | [
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Action of surface-active substances on biological membranes. II. Hemolytic activity of nonionic surfactants. | The hemolytic action of commercially available nonionic surfactants and synthesized polyoxyethylene fatty acids and mercaptans on human erythrocytes was measured. It is shown that the hemolytic power of the detergents depends on the mutual effect of the hydrophobic and hydrophylic fragments of the agent molecule and do... | 623,743 | [
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Is the Ca2+-sensitive K+ channel under metabolic control in human red cells? | It is widely known that a rise in internal Ca2+ leads to an increased K+ permeability of human red blood cells [1,2,3]. Binding of Ca2+ to some membrane receptors is required for the opening of the K+ channel [4]. This requirement, however, seems to alter after "ageing" red cells in vitro in acid-citrate-dextrose solut... | 623,747 | [
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Molecular size and fidelity of DNA polymerase alpha from the regenerating liver of the rat. | DNA-dependent DNA polymerase has been extracted from the soluble cytoplasmic fraction of regenerating rat liver and purified using phosphocellulose and DEAE-cellulose chromatography. Glycerol gradient analysis showed that the enzyme was predominantly DNA polymerase alpha, having a sedimentation coefficient of 10.5 S at... | 623,756 | [
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0.2863064,
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... |
Histone H5 in nucleated erythrocytes of fish as determined by radioimmunoassay. | Tissue-specific histone H5 in the nucleated erythrocytes of dogfish, scup, skate, tautog, sea robin and toad fish was studied. The presence of this histone was inferred by its electrophoretic mocility on polyacrylamide gels containing either acid-urea or sodium dodecyl sulfate. By radioimmunoprecipitation assays, cross... | 623,759 | [
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... |
Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors. | 4-Aminobutyrate:2-oxoglutarate (4-aminobutyrate:2-oxoglutarate amino-transferase, EC 2.6.1.19) from human brain has been purified 2500-fold with respect to the initial homogenate. The enzyme, which appears to be pure by polyacrylamide gel electrophoresis, N-terminal analysis and immunodiffusion, was compared to rat bra... | 623,769 | [
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Properties of a beta-D-mannosidase from Aspergillus niger. | The beta-D-mannosidase (beta-D-mannoside mannohydrolase, EC 3.2.1.25) from culture filtrate of Aspergillus niger has been purified in large amounts by fractionation with (NH4)2SO4 and DEAE-cellulose chromatography. The removal of traces of alpha-D-galactosidase was performed on a Sepharose-epsilon-aminocaproyl-galactos... | 623,772 | [
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... |
A methodological problem in thermoanalytic studies arising from admixed fluoride in the samples. | At a temperature just above the collagen denaturation point the aluminium walls of the pans used in microcalorimetric measurements react exothermically with NaF in test solutions. This formation of the fluor-aluminium complex cryolite is assumed to be catalyzed by the denaturing collagen. | 623,787 | [
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The effect of ammonium nitrate on the synthesis of nitrogenase and the concentration of leghemoglobin in pea root nodules induced by Rhizobium leguminosarum. | The effects of NH4NO3 on the development of root nodules of Pisum sativum after infection with Rhizobium leguminosarum (strain PRE) and on the nitrogenase activity of the bacteroids in the nodule tissue were studied. The addition of NH4NO3 decreased the nitrogenase activity measured on intact nodules. This reduction of... | 623,788 | [
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[Propagation of perturbations in active media with autooscillatory properties]. | Propagation of an activity impulse in the medium where autooscillatory relaxation biochemical reaction takes place is examined theoretically and with the help of the computer experiment. Propagation velocities of the front and shape of the impulse are found. The results are compared with axiomatic theory data on sponta... | 623,800 | [
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[Application of a graphic method for analyzing the kinetics of multienzyme reactions]. | A new graphic method is proposed to solve kinetic equations for polyenzymic reactions. Each graph apex is corresponded by the transmitting function deduced from kinetic equations by means of Laplas transformation. Application of this procedure allows to simplify the solution of kinetic equations and its analysis. The p... | 623,808 | [
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[Electric conductivity of tissue measured in the physiological potential gradient]. | An ability to measure the electric conductivity of tissue in physiological potential gradient is proposed. It has been shown that the resistance of plant leaf during the development of the injured potential is constant. | 623,815 | [
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[Contribution of individual structural components to stabilization of the secondary structure of double-helical polynucleotides]. | Contributions of individual structural components of the double-helical polynucleotide to the stabilization of its secondary structure have been studied. The energy of intramolecular interactions was calculated by the method of atom-atom potentials. Sections of the energy function were constructed according to the para... | 623,820 | [
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[Dipole cooperative model of ion channels in excitable biomembranes. I. Gating currents]. | The experimental data on gating currents are analyzed in terms of dipole cooperative model of ionic channel. The dependence of displaced charge on potential is calculated. A comparison between the theory and experiment allows to establish the cooperative part of the charged gating subunits energy. It is shown that kine... | 623,827 | [
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0.0... |
[Spectral transformations of photoproducts in Halobacterium halobium cells]. | Long-living spectral products observed earlier in purple membranes (PM) are discovered in the cells of Halobacterium halobium (Hh) under the action of yellow light. Blue spectral region of the light has been found to be optimal for PM arising in the cells cultivated under light. On the basis of the changes discovered i... | 623,831 | [
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Intrinsic and extrinsic fluorescence of histones H2A and H2B: a conformational study. | Intrinsic and extrinsic fluorescence measurements suggest that H2A and H2B histones, in a partially secondary structure, self-aggregate into assemblies in which some tyrosine groups are buried in a hydrophobic environment and show enhanced fluorescence, 2-p-toluidinylnaphthalene-6-sulfonate (TNS) indicates heterogeneit... | 623,868 | [
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0.... |
Thermal membrane potential across charged membranes in 2-1 and 1-2 electrolyte solutions. | Measurements of thermal membrane potential across cation exchange membranes in MgCl2, CaCl2 and BaCl2 solutions and across anion exchange membranes in K2SO4, Na2SO4 and K2CO3 solutions were carried out. The magnitude of the thermal membrane potential for divalent counterions is lower than that for monovalent counterion... | 623,869 | [
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Gas chromatography mass spectrometry studies on biologically important 8-aminoquinoline derivatives. | Several substituted 8-aminoquinolines related to known antimalarial drugs have been studied by gas chromatography mass spectrometry. 5,6-Dihydroxy-8-aminoquinoline, a possible metabolite of Primaquine, can be detected by single ion monitoring after conversion to a trimethylsilyl ether derivative. The mass spectra obtai... | 623,897 | [
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Fetal erythropoiesis in steel mutant mice. III. Defect in differentiation from BFU-E to CFU-E during early development. | Erythroid progenitor cells in +/+ and Sl/Sld fetal livers manifested as burst-forming units-erythroid (BFU-E) and colony-forming units-erythroid (CFU-E) were assayed in vitro during early development. The proportion of BFU-E was higher as mutant than in normal fetal livers. On the other hand, the proportion of CFU-E wa... | 623,914 | [
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0.1567307... |
The metabolism of prostaglandins by the guinea-pig uterus with particular reference to corpus luteal maintenance in early pregnancy. | 1 Homogenized lung tissue from day 15, pregnant and non-pregnant guinea-pig metabolized exogenous prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) almost completely when incubated in Tyrode solution containing beta-nicotinamide adenine dinucleotide (NAD+). 2 Metabolism of PGE2 and PGF2alpha by homogenates ... | 623,934 | [
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A clinical scale for the self-assessment of irritability. | To date there has been no suitable scale for the self-assessment of irritability in the clinical situation. Existing scales have either included aspects of personality trait together with present state or they have been constructed on non-clinical populations. A self-assessment scale has been constructed which seeks to... | 623,950 | [
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Noradrenaline neuron innervation of the neocortex in the rat. | Noradrenaline innervation of the rat neocortex is studied by glyoxylic acid histochemistry and radioisotopic biochemical analysis. The data indicate that all neocortical areas receive a noradrenergic innervation which is identical in organization but varies in density from area to area. Radioisotopic analysis of catech... | 624,057 | [
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... |
An automated multi-calorimeter system: preliminary experiments on laying hens. | 1. An open-circuit, automated, multi-calorimeter system for studies on the energy metabolism of the fowl is described. 2. Discontinuous observations of 10-min duration once each hour for 22 h gave good agreement with continuous observations throughout 22 h. 3. It is essential to train each hen before a series of calori... | 624,094 | [
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The carcinogenic effect of dimethylnitrosamine in laboratory bred European hamsters (Cricetus cricetus). | The carcinogenic effect of dimethylnitrosamine (DMN) s.c. injected at two different dose levels was studied in laboratory bred European hamsters (EH) and data compared to findings for captured EH. Malignant haemangioendotheliomas of the liver and kidney, hepatocellular carcinomas and cholangiocarcinomas were induced. I... | 624,110 | [
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Mutagenicity to mammalian cells in culture by (+) and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrenes and the hydrolysis and reduction products of two stereoisomeric benzo(a)pyrene 7,8-diol-9,10-epoxides. | The mutagenicity for mammalian cells of benzo(a)pyrene (BP) and 9 of its derivatives was tested by resistance to ouabain in Chinese hamster V78 cells. The derivatives included the (-) and (+) enantiomers of trans-7,8-diol; the racemic (+/-)trans-7,8-diol; two triols, (7/8,9)-triol and (7,9/8)-triol; and four tetrols, (... | 624,112 | [
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Effects of N-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian golden hamsters. | N-Nitrosodiethanolamine (NDEA) and 1,1-diethanolhydrazine (DEH) were synthesized and injected subcutaneously weekly in male and female Syrian golden hamsters. The total NDEA dose per hamster was approx. 15 g/kg body wt. applied in either 7 or 27 subdoses. DEH was administered in 78 applications to two groups yielding t... | 624,114 | [
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... |
Recurrent sustained ventricular tachycardia. 1. Mechanisms. | The mechanism of recurrent sustained ventricular tachycardia (VT) was evaluated in 21 patients. Re-entry as the mechanism for VT was suggested by a) the reproducible initiation (19) and termination (15) of the arrhythmia by programmed stimulation. The rate, ventricle of origin, and stimulation site determined the metho... | 624,152 | [
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0.2738584,
0.2541191,
-0.3277305,
... |
Normalization of bundle branch block patterns by distal His bundle pacing. Clinical and experimental evidence of longitudinal dissociation in the pathologic his bundle. | Clinical and experimental observations in which bundle branch block patterns (BBBP) in ECG leads were normalized by distal His bundle (H) pacing are reported. The clinical material includes four patients with acute right BBBP secondary to anterior wall myocardial infarction and three patients with chronic left BBBP. Si... | 624,157 | [
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0.1563698,
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0.02998544,
0.1737872,
0.0711... |
A guide to the radiographic identification of prosthetic heart valves. | To facilitate the radiographic identification of prosthetic heart valves, radiographic silhouettes of various aortic, mitral and tricuspid valve prostheses were analyzed and shematized. Forty different prosthetic valve models (heterograft and mechanical) were obtained from seven domestic manufacturers. Each prosthesis ... | 624,173 | [
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0.5400267,
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0.2036587,
0.3279954,
0.1166204,
... |
Percutaneous transhepatic cholangiography with the Chiba Needle. | Percutaneous transhepatic cholangiography using the Chiba needle has been performed on 102 patients. There was an overall success rate of 86 out of 102 cases (84%). Dilated bile ducts were successfully demonstrated in 61 out of 65 patients (94%) and non-dilated ducts in 25 out of 37 patients (70%). Gallbladder filling ... | 624,195 | [
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0.3495255,
0.1830275,
0.1883663,
0.34... |
Selection of tumors with a poor prognosis in operable carcinoma of the endometrium. | A retrospective review of 405 patients with operable cancer of the endometrium tested the hypothesis that histological grading might serve to select patients with a poor prognosis for additional external radiation. Deaths from disease by the fifth anniversary were 10 times higher (28/109 - 26%) among patients in the po... | 624,196 | [
-0.2186642,
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0.06777744,
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-0.3179115,
-0.3832136,
0.2462254,
-0.2411949,
0.08917835,
0.1982403,
0.02030851,
0.1695291,
-0.01090174,
-0.1697225,
-0.4298087,
-0.2594148,
0.1941392,
0.2877151,
0.161508,
-0.06226887,
0.5236077,
0.4424229,
-0.2714061,
... |
Verrucous carcinoma. | The various clinicopathologic forms of verrucous carcinoma of skin and mucous membrane are reviewed. It is found that the histology and natural history of these well differentiated types of squamous cell carcinoma are remarkably similar. It is concluded that verrucous carcinomas of the head and neck, giant condyloma ac... | 624,235 | [
-0.1057889,
-0.1644745,
-0.1301985,
-0.2020793,
0.3182199,
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0.02116974,
0.4071209,
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0.09434892,
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0.06322088,
0.1078031,
0.05239187,
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0.3426198,
0.1607942,
0.05005443,... |
Uterine total lactic dehydrogenase and isozymes of rats administered steroids. | Endometrial scrapings from intact immature and adult rats as well as from ovariectomized series injected subcutaneously daily for 4 days with estradiol benzoate (0.053 mumol/rat/day) displayed marked increases in total LDH and LDH5 over the controls. The uterine luminal fluids from the estrogen-treated animals were low... | 624,275 | [
-0.1792934,
-0.005796196,
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0.2827227,
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0.04380941,
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0.2120954,
0.08595658,
0.1883319,
0.5134194,
0.03120057,
... |
Isolation of messenger RNA coding for eggshell protein of the DNA-eliminating nematode Ascaris lumbricoides. | Poly(A)-containing RNA from polyploid uterine epithelial cells of Ascaris lumbricoides has been isolated by poly(U)-Sepharose chromatography. The bulk of poly(A)-containing RNA migrates as 18-S RNA in formamide/polyacrylamide gels. In a cell-free wheat germ system, this RNA directs the synthesis of a polypeptide with i... | 624,288 | [
-0.1901431,
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0.44643,
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0.1059188,
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-0.06475098,
0.3375123,
0.3011155,
-0.5466826,
0.16864... |
Studies of the mechanism of polycythemia induced in rats by Ni3S2. | Intrarenal injection of 10 mg Ni3S2 elicits polycythemia in rats. This can be attributed either to direct stimulation or to erythropoietin-induced hyperplasia of erythropoietic elements of bone marrow. While studying the mechanism of this experimental model of polycythemia we noted that: (a) extirpation of the injected... | 624,333 | [
-0.2282038,
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0.08615249,
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0.1421102,
0.1370912,
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0.05825255,
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0.2194228,
0.0852543,
0.275717,
-0.009896843,... |
Human marrow erythropoiesis in culture: III. Ultrastructural and cytochemical studies of cellular interactions. | Human erythroblasts cultured with a methylcellulose clonal assay technique were studied with ultrastructural and cytochemical methods. The intact colonies contained only erythroblasts at a similar stage of maturation, and no macrophages were identified within the colonies. The cultured erythroblasts demonstrated many o... | 624,337 | [
-0.08303493,
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0.241985,
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0.2754818,
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0.06020764,
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0.1019671,
0.1042604,
0.197241,
0.02429218,
0.1282446,
... |
Biotin as a regulator of some haematic parameters and of DNA-content of the liver of old rats. | Biotin administration to old rats (28 months) causes in the blood an increase of ATP, glucose, triglycerides, alkaline phosphatase and a decrease of cholesterol and acid phosphatase; in the liver DNA and electrostatic interactions between DNA and histones are increased. Such parameters come within the values shown by a... | 624,348 | [
-0.02359374,
0.07535025,
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0.148018,
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0.1277705,
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0.03724122,
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-0.08091694,
0.2308406,
0.08778979,
0.172243,
-0.2497789,
... |
Distension of the reticulum decreased food but not water intake by sheep. | The intakes of pelleted alfalfa by hungry sheep were depressed in a rectilinear manner in relation to the amount of water (0-800 ml) added to a balloon in the reticulum (p less than 0.005). Since the consumption of water by thirsty sheep was not altered by these treatments, the reduction in food intake produced by dist... | 624,351 | [
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0.03204945,
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0.1732158,
0.05593101,
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0.110354,
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0.2038965,
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0.110008,
0.2221486,
0.08597143,... |
Correlation between acidic phospholipids and serotonin and between lysolecithin and dopamine in ganglia of the marine mussel, Mytilus edulis. | These studies have demonstrated a positive correlation between the acidic phospholipids and the serotonin content and between the lysolecithin and the dopamine content in the cerebral, pedal and visceral ganglia of Mytilus edulis. These relationships were further supported by experiments utilizing 6-hydroxydopamine and... | 624,353 | [
-0.05554795,
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0.01739768,
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0.1387863,
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0.2451178,
0.1015975,
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0.1245927,
0.1417977,
0.389679,
-0.1026075,
-0.1441787,
-0.0611811... |
Aflatoxin metabolism and absence of cytochrome P-450 in rat colon tissue during vitamin A malnutrition. | Homogenized mucosal linings prepared from vitamin A adequate and deficient male rats were used in metabolic studies of aflatoxin B1 (AFB1). Cytochrome P-420 was identified in both groups which metabolized AFB1 to 4 metabolic products in vitro. The implications of this observation are discussed in relation to colon carc... | 624,362 | [
-0.1595231,
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0.03364732,
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0.2503706,
0.01597517,
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0.3482167,
0.1296858,
0.1740617,
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0.2849658,
-0.453903,
-0.02909436,
-0.02216279,
-0.2310841,
0.3319838,
0.2423747,
-0.0651003,
... |
Changes in placental permeability to corticosterone and estradiol-17beta toward the end of gestation in the rat. | Radioactivity in the fetal plasma 1 h after maternal injection of 14C-4-corticosterone or 14C-4-estradiol-17 beta on day 21 of gestation was markedly higher than that 1 h after injection on day 22. Radioactivity in the maternal plasma was not different on these 2 days. The results suggest that the placental permeabilit... | 624,371 | [
-0.1408235,
0.0445033,
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0.221279,
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0.1721846,
0.1684346,
0.281391,
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0.01840881,
0.1796596,
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0.2811322,
-0.124726,
0.0896805,
0.1854178,
0.233036,
0.1106655,
-0.16249... |
[Inhibiting effect of anabasine, anabasamine and lupinine alkaloids on ethanol action in mice]. | Anabisis aphylla alcaloids anabasine, anabasamine and lupinine (1/6 and 1/3) DL50, intraperitoneally) lowered the locomotion excitation called forth by aethanol (2 mg/g, by mouth) in mice. Lupinine shortened roughly by a foctor of 3 also the duration of aethanol anesthesia. The reduced excitation was attended by fallin... | 624,390 | [
-0.3085716,
-0.3199829,
-0.4338382,
-0.08398556,
0.2024884,
-0.1597111,
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-0.4876663,
0.01166013,
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0.1200638,
0.2340721,
0.4155157,
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-0.3288361,
-0.2633045,
-0.1120039,
0.4364268,
-0.1253721,
-0.1663891,
-0.3290961,
... |
The value of urinary pregnanediol estimation for monitoring early pregnancies. | Urine samples from 76 pregnant women were tested for pregnanediol content during the first 6 weeks of pregnancy. Pregnanediol was measured by gas chromatography in 24-hour urine samples obtained once weekly from 76 randomly selected pregnant women 21, 28, 35, and 42 days after the last menstrual period. Pregnancy was a... | 624,419 | [
-0.1963962,
0.204382,
-0.3802314,
-0.04394282,
0.3397689,
-0.2424971,
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0.1022461,
-0.08680926,
0.1148516,
0.376603,
0.06526277,
0.05404884,
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-0.2496607,
0.2287524,
0.02846888,
0.1542446,
0.3946246,
0.3309821,
-0.04319996,
0... |
Low-dose cortisone for male infertility. | Thirty-eight males with idiopathic infertility were randomly treated with low-dose thyroid and low-dose cortisone. Pregnancy followed treatment with cortisone in 7 of 33 courses and followed treatment with thyroid in 4 of 30 courses (P = 0.5, not significant [NS]). The mean pretreatment count in all patients was 12.3 m... | 624,427 | [
-0.0001065875,
0.0932918,
-0.0253693,
-0.1075113,
-0.1117731,
-0.2880769,
-0.1305398,
0.275108,
-0.2043676,
0.04078859,
0.1620511,
0.3507988,
0.1161746,
0.09119634,
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-0.392136,
-0.003163402,
-0.09297279,
-0.02947966,
0.2516118,
0.09814133,
0.1451249,
-0.0871877... |
Untreated acrodermatitis enteropathica in adults. | In the literature six cases of acrodermatitis enteropathica (AE1 are described in which the patients survived to adult age. In a few of these cases the symptoms diappeared at the onset of puberty, while in the rest the disease had a fluctuating course with long symptom-free intervals and an uncharacteristic symptomatol... | 624,429 | [
-0.2771661,
-0.4046677,
-0.3625708,
-0.4302796,
0.1229377,
-0.2566243,
-0.4446337,
-0.1524318,
-0.2142957,
-0.08362411,
0.4033903,
0.09820107,
0.2899676,
-0.3095587,
-0.6436994,
0.04467087,
-0.1404002,
0.06338016,
-0.1941129,
-0.09343798,
-0.007901537,
0.2226969,
-0.08128... |
Immunologic abnormalities in psoriasis: the inhibition of leucocyte migration by stratum corneum antigens. | The migration inhibition of peripheral blood leucocytes by stratum corneum (SC) antigens extracted from psoriatic scales and normal skin was studied in 25 patients with psoriasis and 12 normal controls. In 44% of patients, the radius of the area of spontaneous migration in the absence of antigen was significantly reduc... | 624,432 | [
0.0147508,
0.05023742,
-0.06861816,
0.2173467,
0.1178807,
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0.1623292,
0.1709015,
0.179226,
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0.0360128,
0.1211917,
0.1094024,
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0.08591457,
-0.1024067,
0.1018585,
0.1892188,
0.3328766,
-0.02481875,
-0.1... |
Geriatric gynecologic problems increasing. | Over a 3-year period, the percentage of geriatric patients with gynecologic problems treated in one Canadian hospital almost doubled. Pelvic pain, uterine bleeding, and voiding problems were the most common symptoms. Concomitant diseases existed in 60% of the patients, with cardiac and pulmonary problems the most frequ... | 624,454 | [
0.02239901,
0.04978099,
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0.08063771,
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0.4758749,
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0.05600128,
-0.1022289,
0.2242645,
0.07249628,
0.1330957,
0.2530009,
-0.2112907,
... |
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