title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A preliminary investigation of the renal and hepatic excretion of gallamine triethiodide in man. | The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in three... | 656,250 | [
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Chenodeoxycholic acid therapy for hypertriglyceridaemia in men. | 1 Ten consecutive patients with hypertriglyceridaemia who adhered to a low carbohydrate diet without complete control of serum triglycerides were started on chenodeoxycholic acid 750 mg daily and followed monthly for 6 months. Nine of these patients were then followed for a further month on placebo capsules and thereaf... | 656,270 | [
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The effects of intravenous isoxsuprine on blood viscosity in patients with occlusive peripheral arterial disease. | 1 Blood viscosity is thought to be a major factor in disorders of the peripheral circulation. 2 Ten patients with obliterative arterial disease received an infusion of isoxsuprine of 20 micrograms kg-1 for 30 min. The infusion was followed by a highly significant and prolonged fall in blood, plasma and serum viscosity,... | 656,271 | [
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(+)-Propranolol clearance, an estimation of hepatic blood flow in man. | 1 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/-)-propranolol administration and remained unchanged durin... | 656,285 | [
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Macrophage-mediated natrual cytotoxicity against various target cells in vitro. I. Macrophages from diverse anatomical sites and different strains of rats and mice. | Adherent, predominantly phagocytic, mononuclear cells expressing spontaneous cytotoxic activity against diverse target cells in vitro were present in various tissues of different strains of rats and mice. Cells with such natural killer capacity were thus everywhere readily available for mobilization and activation. The... | 656,302 | [
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Monocytes and macrophages in malignant melanoma. III. Reduction of nitroblue tetrazolium by peripheral blood monocytes. | Peripheral-blood monocytes from normal individuals and from patients with malignant melanoma reduce nitroblue tetrazolium (NBT). A quantitative assay for dye reduction was applied to 25 healthy donors and 31 patients with malignant melanoma. NBT reduction expressed as dye reduction per monocyte was significantly impair... | 656,304 | [
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Liver blood flow measurements in the portacavally transposed rat before and after partial hepatectomy. | The haemodynamic changes following partial hepatectomy (PH) in the portacavally transposed rat have been studied using an 85Kr clearance technique. Liver blood flow measurements (LBF) were made before and after portacaval transposition (PCT) and PH was performed either immediately or at 3 weeks after transposition and ... | 656,313 | [
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Effects of lymecycline on Mycoplasma pulmonis-induced arthritis in mice. | The effect of lymecycline treatment on arthritis in C3H mice produced 5 months previously by i.v. inoculation of Mycoplasma pulmonis was examined. Treatment had little effect on the severity of the clinical disease. However, there was a marked reduction the severity of the histopathological inflammatory reaction in joi... | 656,320 | [
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Photosynthetic oxygen evolution from hydrogen peroxide. | A study was made of the interactions of flash-illuminated chloroplasts with hydrogen peroxide. We conclude: 1. The oxygen precursor system can be reduced beyond the S0 state to an S-1 state, which can be oxidized to S0 by a single flash. 2. In the dark, a two-electron donation by H2O2 takes place which reduces S2 to S0... | 656,402 | [
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Damage to mitochondrial electron transport and energy coupling by visible light. | The effect of treating mitochondria with visible light above 400 nm on electron transport and coupled reactions was examined. The temporal sequence of changes was: stimulation of respiration coupled to ATP synthesis, a decline in ATP synthesis, inactivation of respiration, increased ATPase activity and, later, loss of ... | 656,406 | [
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Manipulation of fatty acid composition of membrane phospholipid and its effects on cell growth in mouse LM cells. | Fatty acid composition of the phospholipids of mouse LM cells grown in suspension culture in serum-free chemically defined medium was modified by supplementing the medium with various fatty acids bound to bovine serum albumin. Following supplementation with saturated fatty acids of longer than 15 carbons (100 micron) p... | 656,411 | [
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Heat inhibition of reticulocyte protein synthesis. Evidence for a mechanism independent of the hemin-controlled repressor. | Incubation of rabbit reticulocytes at 45 degrees C results in a prompt but reversible decrease in protein synthesis and a concomitant conversion of polyribosomes to smaller aggregates. These effects occur even in the presence of 100 micrometer hemin in the incubation medium. There is also inhibition of heme synthesis b... | 656,422 | [
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Enzymatic oxidation of mercury vapor by erythrocytes. | The formation of glutathione radicals, the evolution of nascent oxygen or the peroxidatic reaction with catalase complex I are considered as possible mechanisms for the oxidation of mercury vapor by red blood cells. To select among these, the uptake of atomic mercury by erythrocytes from different species was studied a... | 656,439 | [
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Purification and properties of two succinate semialdehyde dehydrogenases from human brain. | In human brain there are two major isoenzymes of succinate semialdehyde dehydrogenase (succinate-semialdehyde: NAD+ oxidoreductase, EC 1.2.1.24). They are composed of two apparently identical subunits with a molecular weight of 69 000. The Km (limits) for their substrates NAD+ and succinate semialdehyde are 1.6.10(-5) ... | 656,447 | [
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[Isolation of sarcolemma acetylcholinesterase fractions by gel-filtration through Sepharose 2B]. | Gel-filtration of 0,6 M NaCl and 0,6 M NaCl--0,1% Triton X-100 extracts of freshly isolated sarcolemma through Sepharose 2B (1,5 X 72 cm) has revealed one symmetric peak of acetylcholinesterase activity containing phospholipid and cholesterol, moving faster than fibrinogen and tyreoglobulin. The acetylcholinesterase fr... | 656,488 | [
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Undersulfated urinary glycosaminoglycans in preterm newborns. | The glycosaminoglycans (GAG) isolated from pooled urine of preterm newborns were fractionated by stepwise elution from a Dowex 1-X2 column. Analytical reactions, cellulose acetate electrophoresis and enzymatic digestions with chondroitinases and testicular hyaluronidase were performed on each fraction. Chondroitin-4-su... | 656,519 | [
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A comparison of t-butyldimethylsilyl and trimethylsilyl ether derivatives for the characterization of urinary metabolites of prostaglandin F2alpha by gas chromatography mass spectrometry. | t-Butyldimethylsilyl and trimethylsilyl ether derivatives of a series of methylated prostaglandin F2alpha metabolites have been compared with respect to their gas chromatographic and mass spectrometric properties. The t-butyldimethylsilyl derivatives had considerably higher retention indices (approximately 2.2 C units ... | 656,559 | [
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[Effect of neuroleptics on acetylcholine metabolism in the basal ganglia of the brain]. | Neuroleptics (haloperidol) closapine, pimozid, chlorpromazine) diminished the level of free (functionally active) form of acetylcholine (ACh), and, to some extent, the bound form of ACh; they changed the content of the labile-bound (vesicular) form of ACh and weakly influenced the choline-acetyltranspherase activity in... | 656,581 | [
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[Stimulation and suppression of contact dermatitis in mice with a low-molecular thymic humoral factor]. | The authors studied the influence of the low molecular lymphocyte-stimulating substance (LSS) of the thymus on the development of contact sensitivity to picrylchloride in mice. As revealed, low LSS doses enhanced, and high doses suppressed this type of delayed hypersensitivity. Contact sensitivity was passively transfe... | 656,604 | [
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Terminal stages of erythroid differentiation: persistent production of globin messenger RNA is necessary to sustain globin synthesis. | The kinetic relationship between the globin mRNA accumulation and the rate of synthesis of globin chains was studied during the terminal stages of differentiation in erythroid cells derived from the yolk sac of mouse fetuses. RNA derived from the whole cells and from different cell compartments were hybridized to DNA c... | 656,625 | [
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A health sciences libraries consortium in a rural setting. | The coming of the East Tennessee State University College of Medicine and its effect on the health sciences institutions and practitioners in upper east Tennessee (southern Appalachia) required increased and improved information resources and arrangements for delivery and for use. The Tri-Cities Health Sciences Librari... | 656,655 | [
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Evaluation of a library program in a Carnegie model area health education center. | The evaluation strategy of a medical library program within an Area Health Education Center is described. One of about thirty programs in the AHEC project, this library program was singled out as the first to be evaluated both because it was considered a key part of the total program and because a fair amount of quanti... | 656,656 | [
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Perioperative care: intraoperative fluid balance. | Rational intraoperative fluid therapy is based on an understanding of the pathophysiology of severe trauma and surgery. Fluids of suitable compositions are administered in sufficient quantities to form part of the daily maintenance requirement and also to replace blood and ECF lost during surgery. | 656,683 | [
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The influence of an extraneuronal compartment on the relaxation of the cat nictitating membrane in vivo. | 1 Contractions of the cat nictitating membrane were elicited on stimulation of the internal carotid nerve, and the effects were studied of desipramine and two inhibitors of catechol-O-methyltransferase, U-0521 and pyrogallol, on the subsequent relaxation of the muscle. 2 The relaxation of the nictitating membrane occur... | 656,700 | [
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The effects of adenine nucleotides on cutaneous afferent nerve activity. | 1 The activity produced by the adenine nucleotides adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) and by potassium, acetylcholine (ACh), 5-hydroxytryptamine (5-HT) and bradykinin when applied to an exposed blister base on the ear of anaesthetized rabbits or intra-arterially ... | 656,702 | [
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Platelet and plasma amine oxidase activity in alcoholic individuals. | Platelet and plasma amine oxidase activity was determined in a group of 99 healthy male (active duty military) alcoholics referred for hospital treatment who had been abstinent from alcohol for 2-10 days, and compared with that of a control military group. Platelet MAO activity was slightly but significantly lower in t... | 656,722 | [
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A note on the development of recall of spatial location. | Recall of spatial location was studied with 5, 8, 12--13, and 17--18 year old subjects. Pictures of objects were shown one at a time in one of the four quadrants of a projection screen which was either blank (NF) or divided by a cross into four quadrants (F). The presence of the frame (F) did not affect item recall, bu... | 656,732 | [
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An intra-cultural investigation of susceptibility to 'perspective' and 'non-perspective' spatial illusions. | Conventional Müller-Lyer and modified Müller-Lyer (without 'perspective' cues) illusions were presented to two samples of children aged between eight and 19, matched in education, but living in 'carpentered' and 'uncarpentered' environments in Zambia. Traditional differences in susceptibility have been obtained with bo... | 656,735 | [
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0.1736978,
0.2785292,
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... |
Strangulating adhesive small bowel obstruction with normal radiographs. | A review of patients having laparotomy for adhesive small bowel obstruction has revealed that many patients have normal radiographs on admission and that this group of patients, who are predominantly women, have delayed laparotomies and are at a significantly increased risk of developing strangulating obstruction while... | 656,765 | [
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Resistance to chenodeoxycholic acid (CDCA) treatment in obese patients with gall stones. | In most patients with radiolucent gall stones who were given chenodeoxycholic acid (CDCA) in doses of 13-15 mg/kg body weight/day the bile became unsaturated in cholesterol, and their gall stones dissolved. The patients whose stones did not dissolve were significantly heavier and fatter than the responders, which sugge... | 656,777 | [
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Maternal and fetal nutrition in south India. | The relation between the nutrition of the mother and that of her baby was assessed in a south Indian community where malnutrition is common and women do not smoke. Unselected mothers and their infants of over 37 weeks' gestation were studied in two groups: those who paid for their care (150) and a poorer group who did ... | 656,780 | [
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[Critical study of the hemodynamic status during anesthesia]. | Physicians must choose the anaesthetics for their patients and select the methods to cheek their haemodynamic status. Experimental works do not always bring sufficient information to help them in their daily practice. Circulatory reaction to a pharmacodynamic agent is diffuse and non-specific. Some examples drawn from ... | 656,991 | [
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The uptake and excretion of nitrous oxide in the newborn. | In the newborn, the uptake of nitrous oxide into the alveolus is very rapid, as is the fall in alveolar levels following withdrawal of the agent. During recovery relatively large volumes of nitrous oxide are excreted in the first minute, after which the excretion rate rapidly declines, most of the gas having been elimi... | 656,994 | [
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0.1229973,
0.02167742,... |
Effects of interactions between different culture fractions of 'phosphobacteria' and Rhizobium on mycorrhizal infection, growth, and nodulation of Medicago sativa. | Interactions between cell-free culture supernatants, cells, and the whole cultures of Rhizobium and phosphobacteria with endomycorrhizal fungi and their effects on growth and nutrition of Medicago sativa grown in a low-phosphate soil were studied. A satisfactory nodulation was greatly dependent on the mycorrhizal symbi... | 657,005 | [
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0.02921823,
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0.2679619,
0.01612591... |
Surcrose uptake by Neisseria denitrificans. | Neisseria dentrificans possesses an inducible sucrose-uptake system. Sucrose is transported as the free sugar and is rapidly converted into polymerized material. Uptake is inhibited by glucose, cyanide, uncouplers of oxidative phosphorylation, and sulfydryl reagents. Glutamate serves as an energy source for uptake. The... | 657,009 | [
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0.166837... |
Treatment of psoriasis with orally administered 8-methoxypsoralen and long-wavelength ultraviolet radiation. | Between May 1976 and September 1977, 51 patients with severe psoriasis were treated with orally administered 8-methoxypsoralen followed by exposure to high-intensity long-wavelength ultraviolet radiation. Clearing of psoriasis occurred in 40 patients (78%) and marked improvement in 5 (10%). Of the remaining patients th... | 657,030 | [
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0.298084,
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Septicemia in children with leukemia. | A review of the hospital records of 164 children with leukemia diagnosed between January 1969 and December 1975 disclosed 51 episodes of septicemia in 43 patients; 57 infectious agents were isolated. Gram-positive bacteria were isolated as frequently as gram-negative bacteria, each type accounting for 45.6% of all the ... | 657,049 | [
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0.03599834,
0.03042542,... |
The impact of a new geriatric program in a hospital for the chronically ill. | Reports of the rapidly increasing proportion of persons aged 65 years and more in Canada and the resultant need for changes in the country's health care system prompted experimental changes in the operation and training procedures at St. Mary's of the Lake Hospital, Kingston, Ont. Aimed at better patient care and at be... | 657,055 | [
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0.03659809,
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0.02361504,
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0.02072902,
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Uncharged nuclear receptors for estrogen in breast cancers. | This study was undertaken to define the incidence and concentration of uncharged nuclear estrogen receptors (RN) in human breast cancer. The concentrations of RN and cytoplasmic uncharged receptor were determined on sucrose gradients following a 4-hr incubation at 4 degrees with 1.6 nM 17 beta-[3H]estradiol in 139 tumo... | 657,133 | [
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0.02276778,
0... |
Light and electron microscope study of osmotically induced tumor necrosis. | Necrosis of 1.5-cm Walker 256 tumors was produced by injecting a strongly hypertonic solution of glucose in and around the growths and by delaying resorption of the solution with serotonin, given s.c. at a distance. The morphological changes occurring in 13 tumors were followed by light and electron microscopic analysi... | 657,134 | [
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0.2754755,
0.0169400... |
Peptichemio in advanced neuroblastoma. | Peptichemio (PTC) is a mixture of six synthetic peptides of m-L-phenylalanine mustard. It acts with both alkylating and antimetabolic effects, interfering with the synthesis of DNA, RNA, and proteins. PTC was administered iv to 18 previously untreated children with advanced neuroblastoma at a dose of 1-1.5 mg/kg/day fo... | 657,165 | [
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... |
G2 sub-population in mouse liver induced into mitosis by lead acetate. | A single intracardiac dose of lead acetate (40 microgram lead/g body weight) induced a 25-fold increase in mitosis of mouse hepatocytes 5 hr after injection, as determined by autoradiography. The prompt appearance of a mitotic wave and the relatively large number of mitoses suggest that the mitotic cells were derived f... | 657,231 | [
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Cell proliferation in EMT6 tumors treated with single doses of x-rays or hydroxyurea. I. Experimental results. | EMT6 mouse mammary tumors were treated in vivo with 5 mg/mouse of hydroxyurea (HU) or 300 rads of X-rays. The proliferation of the tumor cells was followed for 28 hr after treatment. Changes in the 3H-TdR labeling index, the mitotic index, the specific activity of the 3H-TdR-labeled DNA, and the proportion of suspended... | 657,234 | [
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The development of a zonula occludens in peripheral myelin of the chick embryo. A freeze-fracture study. | Sciatic nerves of chick embryos, 12 to 18 days incubation, were examined in freeze-fracture replicas with special emphasis placed on the development of tight junctional contacts in the myelin sheaths. In stages of beginning myelination short isolated particulate chains (focal tight junctions) appear in fracture faces o... | 657,237 | [
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0.069548... |
The reticular formation of lampreys (Petromyzonidae)--a target area for exohypothalamic vasotocinergic fibres. | The octapeptide vasotocin, which is formed in the classical neurosecretory nuclei of lampreys (Petromyzonidae), is transported, bound to the carrier protein neurophysin, not only to the neurohypophysis but also to various other regions of the brain via exohypothalamic fibres. A target area of this exohypothalamic vasot... | 657,248 | [
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The ultrastructure and function of follicle cells in Foucartia squamulata (Herbst) (Curculionidae). | The follicle cells of Foucartia squamulata are involved in the formation of both vitelline membrane and chorion. Precursors for these egg coverings are synthesized by the rough endoplasmic reticulum and condensed within dictyosomes. The vitelline membrane and the chorion appear on the oocyte surface simultaneously, whi... | 657,249 | [
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Dexamethasone-resistant cystic fibrosis fibroblasts show cross-resistance to sex steroids. | Diploid skin fibroblasts derived from individuals with the autosomal recessive disease, cystic fibrosis (CF), were shown previously to be significantly more resistant to the cytotoxicity of dexamethasone, a glucocorticoid hormone, than were normal human fibroblasts. Here cystic fibrosis fibroblasts are also shown to b... | 657,271 | [
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[Our experience in the surgical treatment of perforated duodenal ulcer]. | The Authors present their surgical experience of more than a decade with regard to emergency therapy of perforated duodenal ulcers. The paper covers the case of 124 patients hospitalized urgently and variously subjected to the aspirative method according to Taylor, raphe, vagotomy and pyloroplasty according to Judd, or... | 657,417 | [
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... |
The magnitude of the electromotive force of canine ventricular myocardium. | The isolated and perfused dog heart was placed in a cubic container filled with Tyrode's solution. Ventricular ectopic beats were produced by electrical stimulation of the left ventricular wall, and initial QRS vectors of these beats were determined with orthogonal leads from the surface of the container. At the same i... | 657,434 | [
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Whole body vascular reactivity during the development of deoxycorticosterone acetate hypertension in the pig. | A change in vascular reactivity was characterized in the pig during the development of deoxycorticosterone acetate (DOCA) hypertension. Pigs, 8-12 weeks of age, were subjected to unilateral nephrectomy and instrumented with an electromagnetic flowprobe on the ascending aorta and with Tygon catheters in the aorta and th... | 657,435 | [
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0.4064765,
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0.329706,
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0... |
Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep. | The effects of ouabain or ouabain and furosemide on renal function and renin secretion were studied in conscious isovolemic sheep. The sheep received a continuous renal arterial infusion of papaverine, 7 mg/min, throughout the experiment. Ouabain alone (7 X 10(-7) M in the renal plasma) produced significant decreases i... | 657,458 | [
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Bile acids measured in serum during fasting as a test for liver disease. | Total serum bile acids were estimated by an enzymic (3alpha-hydroxysteroid dehydrogenase) method in 173 fasting patients with different liver diseases, classified into 17 groups by morphological criteria. The results were not highly correlated with those for any of the other 24 tests included in the study, but moderate... | 657,487 | [
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0.02312827,... |
A simple colorimetric method for ascorbic acid determination in blood plasma. | The paper describes a simple method for determination of ascorbic acid using acid phosphotungstate. The reagent has been found to be specific and sensitive to ascorbic acid and can be used for ascorbic acid determination in plasma with good reproducibility. | 657,538 | [
-0.1557558,
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Hypersialyloligosacchariduria in mucolipidoses: a method for diagnosis. | A method is described for the detection of abnormal oligosaccharides in a small (5 ml) volume of urine, employing filtration on a Bio Gel P-6 column, determination of neutral sugar and bound sialic acid, and determination of creatinine content. With this method increased urinary excretion of sialic acid-rich oligosacch... | 657,539 | [
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Electrophoretic identification of the brain isoenzyme of creatine kinase following treatment with anti-BB antisera. | A procedure is described for accurately determining the presence of true creatine kinase isoenzyme BB by fluorescent staining following electrophoresis on either cellulose acetate or agarose. Treatment of sera with anti-BB inhibiting antibody prior to electrophoresis and subsequent enzymatic staining allows clear ident... | 657,548 | [
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0... |
Turner syndrome with rare karyotypes. | Five cases of Turner syndrome with rare karyotypes are presented. The spectrum of chromosomal findings ranges from a female karyotype with a deletion of the short arm of one X chromosome, to a normal male karyotype. The following karyotypes were found: one case with 46,XXp--; two cases with 45,X/46,X,r(X); one case wit... | 657,581 | [
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... |
Purification and characterization of altered cystic fibrosis liver alpha-L-fucosidase. | alpha-L-Fucosidase (E.C.3.2.4.51) from two cystic fibrosis livers has been purified and characterized. Purification was accomplished by an affinity chromatographic procedure previously used for normal liver alpha-L-fucosidase. Characterization of the two cystic fibrosis alpha-L-fucosidases indicated that they were very... | 657,582 | [
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Studies on cell water and electrolytes in chronic renal failure. | Studies were carried out in 10 normal subjects and in 16 patients with moderately severe chronic renal failure (CRF) to determine the quantities of potassium (K), sodium (Na) and water in muscle tissue obtained by needle biopsy and in white cells (WBC) from peripheral venous blood. Depletion of intracellular K with hig... | 657,596 | [
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Subtrochanteric fractures of the femur treated with nail-plate devices: a retrospective study. | Fifty-four cases of nonpathologic subtrochanteric fractures of the femur were treated by fixation with nail-plate devices. Of the 48 final cases, 42 patients (88%) united successfully after a single operative procedure. Six patients (12.5%) developed a non-union and required further surgery, an experience similar to th... | 657,621 | [
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Recurrent osteoblastoma: a review. | A review of 3 new osteoblastomas and 181 previously reported osteoblastomas revealed 18 recurrences (9.8% recurrence rate). Recurrence was more common in the spine and pelvis. Recurrences were reported as late as 9 years after excision of osteoblastomas and long-term follow-up is indicated in this lesion. Five recurren... | 657,629 | [
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67Ga scintigraphy in lymphomas with special reference to cardiac apical mass. | The cardiac apical mass of Hodgkin's disease, an infrequent presentation of lymphomas, can be selectively labeled with 67Ga-citrate. Three cases are presented illustrating the value of 67Ga scintigraphy in the differential diagnosis of pericardial masses, as well as its role in the management and assessment of therapy. | 657,650 | [
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Rehabilitation of the communicatively impaired stroke patient. | The stroke patient who has lost the ability to communicate has lost more than the ability to talk. To one degree or another, he has lost the ability to understand his environment, the ability to structure his thought process internally in a logical and meaningful order, and the ability to formulate language in a logica... | 657,648 | [
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0.294779,
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Demonstration of superior vena caval obstruction and "hot spot" on liver scan in a case of non-Hodgkin's lymphoma. | A case of total superior vena cava obstruction and "hot spot" in the liver demonstrated by a radiocolloid liver scan in a case of non-Hodgkin's lymphoma of the anterior mediastinum, is presented. The study showed total obstruction of the superior vena cava and the presence of collateral circulation. The patient receive... | 657,679 | [
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0.3429... |
Congenital lobar emphysema. | Congenital lobar emphysema is an uncommon but potentially life-threatening cause of respiratory distress in the newborn. The clinical picture and radiologic findings are diagnostic. Lobectomy in the distressed neonate is curative. In infants with onset of symptoms between one and four months of age surgery may not be n... | 657,700 | [
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One year's experience in a regional poison control center: The Intermountain Regional Poison Control Center. | The Intermountain Regional Poison Control Center in Salt Lake City, Utah, has served as a regional poison center since 1971. Between 1972 and 1976 the call load has more than tripled, with the highest frequency of calls per population coming from counties most proximate to the center. Two-thirds of the cases involve ch... | 657,749 | [
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The AaDO2 and venous admixture at varying inspired oxygen concentrations in chronic obstructive pulmonary disease. | The alveolar to arterial oxygen pressure difference (AaDO2) and pulmonary venous admixture (Qs/Qt) were measured in 32 patients with chronic obstructive pulmonary disease during right heart catheterization at inspired oxygen concentrations (FIO2) of 21, 24, 28, 35, and 40%. Patients without chronic hypercapnia (PaCO2 i... | 657,813 | [
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The effect of salicylate infusion on the alveolar epithelial membrane in the isolated perfused lung. | We observed two patients with aspirin (ASA) ingestion (blood levels of 87 and 56.5 mg/100 ml) who presented with noncardiogenic pulmonary edema (adult respiratory distress syndrome. To determine if ASA had a direct effect on the alveolar epithelial membrane, we established an in vitro isolated lung model and perfused i... | 657,822 | [
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Xanthomas and lipoproteins. | Xanthomas and lipoprotein abnormalities are important to all physicians. Many factors affect the synthesis and degradation of cholesterol and triglyceride, the lipids of major importance in these disorders. Lipids travel in serum bound to protein moieties, forming lipoproteins. Hyperlipoproteinemias may be either prima... | 657,837 | [
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0.2699964,
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Experimental hydrocephalus: cerebrospinal fluid dynamics and ventricular distensibility during early stages. | Adult craniectomized cats, rendered hydrocephalic by intracisternal kaolin injection, were repeatedly studied as to parameters pertaining to cerebrospinal fluid (CSF) dynamics and ventricular size. Intraventricular pressure was up to 8-fold of normal (mean 17.1 cm H2O) initially after induction of hydrocephalus and the... | 657,883 | [
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Surgical treatment of spasticity in cerebral palsy. | Since 1971, we have surgically treated spasticity in 109 cases of cerebral palsy with posterior rhizotomy. The best results have been obtained with functional posterior rhizotomy, an original modification of Foerster's technique, in which the selection of the roots/rootlets to be sectioned is based on functional explor... | 657,884 | [
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0.165863,... |
Sex-related differences in response to practice on a visual-spatial test and generalization to a related test. | 93 first graders (mean age 6.5 years) were given a pretest and posttest on half of the items from the Children's Embedded Figures Test. Half of the children were randomly assigned to a training condition and received a brief training procedure on visual-spatial disembedding prior to the administration of the posttest. ... | 657,893 | [
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[Cranial complications in extension therapy of cervical fractures. Riechert's modification of extension therapy]. | Cranial complications are reported in the treatment of cervical injury by Crutchfield skull caliper traction. The mechanical causes are discussed and a new skull caliper is demonstrated. | 657,898 | [
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[Fractures of the distal end of the femur and their management using condyle plates]. | Forty-one patients with fractures of the distal end of the femur are investigated and the importance of the angular plate designed by the AO group for stabilization of these fractures is discussed. For good results it is necessary to have the complete set of instruments and to consider biomechanical principles for stab... | 657,900 | [
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Changes in the rectal mucosa induced by hypertonic enemas. | The aspect of the rectal mucosa after administration of hypertonic enemas is occasionally confused with the macroscopic appearance of quiescent ulcerative colitis. Criteria for a diagnosis of enema reaction were derived from a retrospective series and tested prospectively on 11 healthy volunteers. Photographs and biops... | 657,932 | [
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Well-differentiated adenoma at the anorectal junction. | Twenty-six cases of patients having adenomatous polyps at the anorectal junction are presented. Most polyps in this region were well-differentiated, and atypical polyps were infrequently seen. Well-differentiated adenomatous polyps in the anorectal junction were larger in average size than ordinary colorectal polyps ha... | 657,935 | [
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Tinidazole in the treatment of trichomoniasis, giardiasis and amoebiasis. Report of a multicentre study. | An open multicentre trial was undertaken in 8 countries to assess the efficacy and tolerance of short course treatment regimens of tinidazole Trichomoniasis: of 859 patients with trichomonal vaginitis given a 2g single dose of tinidazole 717 (95.2%) were cured. Side-effects occurred in 82 patients (9.5%) and in 12 were... | 657,995 | [
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[Incorporation of glycine(14C) into liver proteins during low energy laser pulse irradiation]. | The authors examined the action of irradiation with ruby lazer at lambda=6,948 A and level of energy 0.13 j/sm2. Liver of rats was irradiated through the surrounding tissues in five successive impulses. The skin in the region of action was stained with methylene blue. Changes in the incorporation of the label in the fr... | 658,005 | [
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On the activity of RNA polymerase B in lysates from Ehrlich ascites cells. | Transcription by endogenous RNA polymerase B in lysates of Ehrlich ascites cells was investigated. The enzyme exhibits two salt optima at 0.025 M and at 0.3 M (NH4)2SO4 respectively. Preincubation of the cells with the nucleoside analogue 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole results in an inactivation of th... | 658,042 | [
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Ultrastructural changes of the intestinal wall after transileal cutaneous ureterostomy in men. A preliminary study. (With 1 color plate). | Pre- and postoperative specimens of ileal loops used in transileal ureteroplasty have been taken and ultrastructural modifications concerning the intestinal mucosa with special attention to the epithelial cells are described. The enterocytes undergo significant modifications because of the operation (i.e. collapse of s... | 658,075 | [
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Quantitative element investigations in urine, serum, kidney and muscle tissue of calcium oxalate stone patients. | Concentration and excretion in 24-hour urine, as well as serum concentrations of Na, K, Mg, Ca, Cl, P, uric acid and citrate were investigated in 209 calcium oxalate stone patients and 42 stone-free patients. Especially the concentration values of the urine components, except for uric acid and citrate, were found to be... | 658,076 | [
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0... |
Pharmacokinetics and side-effects of clonidine. | A single oral dose of clonidine 300 microgram was administered to 8 healthy, normotensive subjects and the time course of its plasma concentrations was followed for 24 h. The plasma concentration of clonidine rose to a peak of 1.17 +/- 0.12 ng/ml at about 2 h: the absorption half-life was 0.6 +/- 0.2 h. Elimination fol... | 658,114 | [
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Analgesia by enkephalins injected into the nucleus reticularis gigantocellularis of rat medulla oblongata. | Methionine-enkephalin (0.2--20 microgram/rat) and leucine-enkephalin (1--20 microgram/rat) produced a dose-related and naloxone-antagonizable analgesia in the tail-pinch test, when microinjected into the nucleus reticularis gigantocellularis (NRGC) and nucleus reticularis paragigantocellularis (NRPG) of the medulla obl... | 658,122 | [
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Naloxone does not antagonize leukocytic pyrogen. | In a crossover experiment, cats were given third cerebral ventricular injections of 500 microgram naloxone hydrochloride or saline vehicle followed in 15 min by i.v. injections of saline solution or leukocytic pyrogen. The pyrogen produced comparable fevers after both saline and naloxone pretreatment. Intravenous admin... | 658,144 | [
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0.1850391,
0.231656,
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... |
Statistical dependence between neighboring retinal ganglion cells in goldfish. | Simultaneous recordings were made of the spontaneous discharge of neighboring retinal ganglion cells in goldfish. Crosscorrelation analysis indicates two types of correlation. Neighboring units with like receptive field organization tend to discharge together while units having complementary receptive field organizatio... | 658,187 | [
0.2189405,
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... |
Activity of the reticuloendothelial system following exposure to electric stress and thymectomy. | After electric stress stimulation, granulopectic activity is reduced in otherwise normal rats, whereas it appears to be increased in thymectomized animals. The differences between the 2 groups of animals seem to support the hypothesis that the effects of stress upon the overall phagocytic capacity may be mediated by th... | 658,233 | [
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... |
Specific in vivo binding of d-LSD in rat brain. | A reproducible in vivo d-LSD binding method in rat brain is described, with high affinity (Kd of 5 pmoles/g wet wt), stereospecificity (d- vs. 1-LSD) and regional selectivity. It may be a useful adjunct to in vitro methods for measuring changes in turnover at the synaptic level related to the intact receptor. | 658,293 | [
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... |
The acidic glycosaminoglycans in gasric mucosa of athyroid rats: The effects of L-tri-iododthyronine. | Hyaluronic acid is increased about 12%, whereas dermatan sulfate is decreased about 34%, in gastric mucosa of athyroid rats when compared with controls. Administration of 2 doses of L-tri-iodothyronine reversed the effects of thyroidectomy. | 658,311 | [
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Contraceptive patterns and premarital pregnancy among women aged 15--19 in 1976. | About 780,000 teenagers experience a premarital pregnancy each year. If they weren't using contraception, an additional 680,000 would become pregnant--a total of 1,460,000. However, if all who did not want a baby were practicing contraception consistently, we could reduce the number of pregnancies by at least 313,000. ... | 658,317 | [
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0.00455861... |
[Effect of phenobarbital on sulfanilamide acetylation]. | By using the "turned inside out bag" technique and brough tests with homogenates it was found that sulfanilamide is susceptible to acetylation in a larger measure than sulfocarbamide and sulfacylum natrium. In tests with isolated lengths of the small intestine phenobarbital (in doses of 25 mg/kg for 5 days) weakened ac... | 658,368 | [
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[Effect of pharmacological agents on the membrane hydrolysis of saccharose]. | Membranous hydrolysis of saccharose (membranous digestion) and synthesis of invertase in the intestinal epithelial cells of rats and mice following introduction of pharmacological agents were studied. Ethyl alcohol, luminal and atropine lowered both the invertased activity in the area of membranous digestion and the sy... | 658,382 | [
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... |
[Effect of x-ray contrast substances on the metabolism of xenobiotics and steroid hormones by rat liver microsomes]. | Uro- and cholecystographic contrast media are shown to be capable of changing the rate of oxidative hydroxylation of amidopyrine and steroid hormones. The degree and duration of the diminishing rate of the xenobiotics and steroids metabolism are determined by concentrations of the X-ray contrast media in hepatic cells ... | 658,383 | [
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0.1575285,
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Development and organization of multimodal representation in cat superior colliculus. | The present paper examines developmental and organizational parallels between visual and nonvisual cells in the cat superior colliculus (SC). An attempt is made to relate these developmental and organizational features to the role the SC plays in orientation behavior. In young kittens visually guided behavior is virtua... | 658,465 | [
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0.02069918,
0.3457999,
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The bipolar needle for vasectomy. I. Experience with the first 1000 cases. | A battery-powered, bipolar electrocoagulator has been specifically developed for sealing the cut ends of the divided vas at vasectomy. With a minimum of electric power, the electrocoagulator destroys only the mucosa and one or two muscle cell layers of the vas, which leads to optimal fibrosis of the cut ends. This inst... | 658,480 | [
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0.09456143,
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[Analysis of the interstructural relationships in the brain by the method of bioregulated micropolarization]. | In chronic experiments on cats, automatic regulation of polarizing current, monitored with the EEG changes, aided to study elements of the cerebral selfregulating system. The method proved effective for influencing the functional state of the structures to be regulated which revealed itself in long-lasting shifts of th... | 658,508 | [
0.00873867,
0.4254799,
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0.1330377,
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0.04947013,
0.01606942,... |
[Composition and excitability of afferent fibers of the pelvic nerve in cats]. | The afferent fibers excitable by pelvic nerve stimulation were as follows: A (81 m/sec), A (59.6 m/sec), A (45.3 m/sec), A (17.9 m/sec), A (31.6 m/sec), B (11.3 m/sec). We failed to find C fibers. Analysis of the distribution of fibers showed that the majority of them entered the S2 dorsal root (DRS2). The fast-conduct... | 658,511 | [
0.1465625,
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0.01323261,
... |
[Relationships between central and local mechanisms regulating hemodynamics]. | The quantitative analysis of hemodynamic shifts during cardiovascular responses to stimulation of central neural structures, and recording of electric activity from the sympathetic fibers elucidate different links in the complex mechanism of the hemodynamic control. Monosynaptic connections of the sino-aortic zone with... | 658,533 | [
0.1125065,
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0.4551399,
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0.15019... |
[Functional state of the vasomotor center in the presence of afferent influences from reflexogenic zones]. | Redundant afferentation from reflexogenic zones of the lung and skeletal muscles alters effects of electric stimulation of the midbrain reticular formation and posterior hypothalamic nucleus in the cat due to readjustment of the cortico--subcortical interrelationships and to an increase in the excitability of the brain... | 658,536 | [
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0.117616,
0.04773661,
... |
[Identification and study of sympathoactivating neurons of the medulla oblongata]. | The neurons with descending axons which activate the lateral horn sympathetic preganglionic (vasomotor) neurons were searched in the lower brain stem of the cat. Localization of these sympathoactivatory neurons in the limit zone of medulla was outlined by means of scanning stimulation. The identification of single bulb... | 658,539 | [
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0.0158175,
... |
The effects of demographic factors, family background, and early job achievement on age at marriage. | National data for ever-married men age 20 to 65 in March 1973 are utilized to estimate least squares and log-linear structural equation models of age at marriage. We demonstrate that most characteristics of family background (including both the family structure and its socioeconomic standing) are irrelevant in their ef... | 658,558 | [
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... |
Dapsone-induced distal axonal degeneration of the motor neurons. | Dapsone proved to be effective treatment in a patient who suffered from erthema elevatum diutinum. Serious neurological side effects, however, appeared. The basic mechanism appeared to be a distal axonal degeneration of the motor neurons. Sensory conduction studies were normal in five consecutive EMG examinations. A d... | 658,572 | [
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0.0974255,
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0.2976802,
0.3606824,
0.4281454,
0.1696386,... |
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