title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Birefringence of oriented thin filaments in the I-bands of crab striated muscle and comparison with the flow birefringence of reconstituted thin filaments. | Birefringence of the I-band of glycerinated myofibrils of the walking legs of the crab, Plagusia dentipes was examined by rectified polarization optics. The coefficient of birefringence of the I-band was estimated to be 1.64 X 10(-3), which attained about 60% of the birefringence of the H-zone. The number ratio of thin... | 710,413 | [
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Mechanism of spermine stimulation of rat-liver isoleucyl-tRNA formation. | The mechanism of spermine stimulation of rat-liver isoleucyl-tRNA formation has been studied by Cleland's method [Biochim. Biophys. Acta, 67, 104--137 & 173--197 (1963)]. It was demonstrated that isoleucyl-tRNA formation proceeded through a ping-pong mechanism in the presence of spermine and magnesium. From a study... | 710,414 | [
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Anthracycline antitumor antibiotic nucleic-acid interactions. Structural aspects of the daunomycin poly(dA-dT) complex in solution. | The helix-to-coil transition of the synthetic DNA poly(dA-dT) in the presence of the anthracycline antitumor antibiotic daunomycin has been investigated by high-resolution proton nuclear magnetic resonance (NMR) spectrocopy in 1 M salt solution. The dissociation of the complex, containing molar ratios of phosphate to d... | 710,429 | [
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Studies on the structure of rat-liver polysomes by small-angle X-ray scattering. | The spatial structure of rat liver polysomes in dilute solution has been studied by the small-angle X-ray scattering technique. The distance between the mass centres of neighbouring ribosomes on the mRNA molecule is 35 nm, and the distance from next-but-one neighbour, about 55 nm. The spatial arrangement of the ribosom... | 710,447 | [
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The dependence of cerebral blood flow on age. | Cerebral circulation time was studied with angiography of the carotid artery within a group of 45 normal cases of different age. The results showed an approximately linear increase of the circulation time with age, the coefficient of which amounts to 1% per year. For an average age of 35 years the average circulation t... | 710,454 | [
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Radical surgery for renal cell carcinoma. | A modified radical nephrectomy to cope with renal carcinoma presenting at advanced stages, is evaluated. A total of 50 cases were treated in this hospital from 1962 to 1976. The poor results from treatment of renal cell carcinoma in the earlier years, have prompted the modification of the conventional radical nephrecto... | 710,464 | [
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Fungus ball formation of aspergillus in the bladder. an unusual case report. | An unusual case of fungus ball formation of Aspergillus in the bladder without any evidence of disseminated and renal aspergillosis is presented. A 49-year-old man whose chief complaint was progressively worsening dysuria after a stomach operation was admitted. Cystoscopy revealed many ball-like masses on the retrotrig... | 710,472 | [
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Application of high-powered microwave irradiation for acetylcholine analysis in mouse brain. | Acetylcholine (ACh) levels in whole brains or discrete areas of mice brains were measured after sacrificing by decapitation, conventional or high-powered microwave irradiation. ACh levels in mice brains varied according to the time required to inactivate the enzymes. ACh levels after high-powered microwave irradiation ... | 710,504 | [
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Beta-adrenergic thirst and its relation to the renin-angiotensin system. | Isoproterenol is a potent dipsogen and antidiuretic agent. It also stimulates the release of renin from the kidney. Evidence is presented to substantiate the view that the drinking and increased vasopressin release that follow the systemic injection of a small dose of isoproterenol are mediated via increased activity o... | 710,589 | [
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Failures following fimbriectomy: a further report. | In 1977 we reported on seven patients who presented with intrauterine pregnancy in spite of previous fimbriectomy; in a detailed morphologic study one tuboperitoneal fistula was documented in each of four patients. In the present study three more patients are reported with pregnancy following fimbriectomy, and another ... | 710,596 | [
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Quantitation of Leydig cells in testicular biopsies of oligospermic men with varicocele. | Leydig cell density was evaluated quantitatively in bilateral testicular biopsies from 16 oligospermic men with varicocele. The method utilized for this quantitation is based on the determination of the total number of Leydig cells, Leydig cell clusters, and seminiferous tubules in the entire histologic section of each... | 710,601 | [
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Binding of steroids to human spermatozoa and its possible role in contraception. | The binding of steroids to human ejaculated spermatozoa and the effect of steroids bound to spermatozoa on sperm migration and motility in vitro was examined. A correlation between progestogens that bind to steroid-binding sites on human spermatozoa and progestogens that inhibit sperm migration was established. The res... | 710,604 | [
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The role of phosphate esters in male fertility. | Spermatozoa do not achieve full maturation and fertilizing capacity until passage through the epididymis. During this time they also gain motility, although spermatozoa do not move until after ejaculation. The organic fraction of human seminal plasma contains phosphate esters, particularly glycerylphosphorylcholine (GP... | 710,605 | [
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[Cytophysiology of the absorption cycle of enterocytes]. | The protein absorption (albumin and gamma-globulin) by epithelial cells of small intestine of neonatal rats was studied in order to define the duration of its stages, the role of intracellular structures in trensport of the absorbed substances, and the cyclic activity of enterocytes. The volume of the absorbed substanc... | 710,629 | [
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Chromatin activation in peritoneal exudate leukocytes after fusion with L cell cytoplasts. | Cells reconstituted from the L cell cytoplasts and nuclei of mouse peritoneal leukocytes (PL) have been obtained by fusion procedures. The dormant nuclei of leukocytes undergo reactivation after fusion with active L cell cytoplasms. The reactivation is manifested by the swelling of nuclei, the increase of 3H-actinomyci... | 710,673 | [
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Sulphydryl requirement for insulin release from the perfused pancreas. Studies with ethacrynic acid and dithiothreitol. | Using the isolated, perfused rat pancreas the importance of sulphydryl groups for the secretory process of insulin was investigated. It was found that ethacrynic acid (EA, 0.075-0.6 mmol/1) caused a dose-dependent, monophasic insulin release. Addition of EA to a glucose-stimulated (20 mmol/1) pancreas led to a sudden i... | 710,755 | [
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[Myocardial infarction in young people. A coronary angiographic study in 21 patients under the age of 30 (author's transl)]. | The Authors have taken into account 21 patients who complained of myocardial infarction before they were 30 years old. We performed coronary angiography, left ventriculography and left cardiac catheterization in all the patients. In 20 cases we found atherosclerotic alterations (50 or greater obstruction) at least in o... | 710,764 | [
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[Usefulness of x-ray parameters in the functional evaluation of patients with nonvalvular cardiopathies]. | In 49 patients suffering of heart diseases we have studied the changes of radiologic cardiac measurements and systolic time intervals (STI) in the four functional classes of the New York Heart Association (NYHA) classification, investigating also the existence of any relationship between these different parameters. Onl... | 710,766 | [
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Predisposition to gastric erosions in the rat: behavioral and nutritional effects of early maternal separation. | After early maternal deprivation (on postnatal day 15), the incidence of restraint-induced gastric erosions on day 30 increases to approximately 5 times that of rats separated at the customary (day 21) weaning age. These data suggest that factors in the mother-infant relationship during postnatal development in young r... | 710,833 | [
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Definitive diagnosis of gluten-sensitive enteropathy. Use of an in vitro organ culture model. | The flat mucosal lesion of the small intestine is not pathognomonic of gluten-sensitive enteropathy (GSE). Frequently, the definitive diagnosis of this condition can only be established after three intestinal biopsies are performed: an initial one to show a flat mucosal lesion, one after a gluten-free diet to show morp... | 710,838 | [
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Binding of secretin to plastic surfaces. | Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the ... | 710,860 | [
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[Conisation during pregnancy (author's transl)]. | The paper reviews 15 cases undergoing conisation during pregnancy. In 2 conisation was immediately followed by radical operation for invasive squamous carcinoma. 11 patients had pre-invasive carcinoma by microscopic evidence on serial step sections, while the remaining 2 showed high-grade dysplasia of the cervix. Atypi... | 710,882 | [
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What we know--and don't know--about bone loss in the elderly. | The incidence of fracture in women increases with age; yet studies of age-associated bone loss have shown conflicting results. Cross-sectional studies show that variation in bone content does not increase significantly with age, supporting the theory that there is a universal bone loss with age, and that women with low... | 710,894 | [
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Lundh test and ERCP in pancreatic disease. | The Lundh test and endoscopic retrograde cholangiopancreatography (ERCP) were used to investigate 40 patients with known or suspected pancreatic disease. Pancreatograms were classified as being normal or showing minimal or gross changes. There was good correlation between the two tests in assessing the degree of pancre... | 710,961 | [
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Parietal cell hyperplasia induced by long-term administration of antacids to rats. | Suspension of magnesium and aluminum hydroxide (30--60 mEq/24h) or a comparable volme of water was orally administered by gastric intubation to two groups of 20 male Wistar rats each over 60 days. The antacid treatment led to a significant increase in the height (0.464 +/- 0.02 mm v. 0.318 +/- 0.06) and in the volume (... | 710,969 | [
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Dupuytren's disease--the influence of occupation and previous hand injuries. | The influence of handedness, work and previous hand trauma is studied in 901 persons with Dupuytren's disease, collected in an epidemiological study of 15,950 citizens in a small, Norwegian town. Dupuytren's disease occurred in all occupational groups, but the prevalence was higher and the contracture more severe in pe... | 710,978 | [
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Reconstruction of the digital tendon-sheath in "no-man's" land with autologous transplanted vein-graft. | A two-stage procedure is described for severely damaged flexor tendons in "no man's land". In the first stage the damaged tendons and scarred tendon sheath are excised and a segment of the saphenous vein, cannulated by a silicone rubber rod is transplanted into the tendon bed. In the second stage the silicone-rod is re... | 710,980 | [
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Carpal tunnel syndrome due to thrombosed persisting median artery. A case report. | Surgical intervention for carpal tunnel syndrome in a seventy year old woman revealed thrombosis of a double persisting median artery. The persisting median artery is a rare anomaly and its association with a thrombotic process to cause carpal tunnel syndrome is even rarer. Carpal tunnel syndrome is a widely-known phen... | 710,985 | [
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0.1247457,
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0.2992569,
0.1892836,... |
The conservative treatment of the Swan-Neck deformity in the rheumatoid hand. | A technique is described to correct rheumatoid Swan-Neck deformity in those patients where there is limited proximal interphalangeal joint flexion in all positions. It involves the manipulation of these joints and their temporary immobilisation with Kirschner wires followed by mobilisation using an elastic band method. | 710,990 | [
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[Observation of animal behavior by revolving activity cage method: A new automatic measuring and recording system of motor activity of a mouse by means of revolving activity cage is presented (author's transl)]. | With this system, several parameters can be recorded continuously over several months without exterior stimuli. Time per revolution is counted and punched into the paper tape as binary coded numbers, and the number of revolutions and the frequency of "passage" in a given time are printed out on a rolled paper by a digi... | 711,027 | [
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... |
[BCG vaccination and leukemia. Epidemiologic studies on the effect of BCG vaccination on leukemia]. | The possible influence of BCG vaccination on leukemia mortality of infants was investigated by various authors. The methods used were prospective trials, retrospective studies and epidemiological analyses. In some of these studies a protective effect of BCG vaccination was observed, in other studies no influence was fo... | 711,119 | [
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Recovery of immune system in diabetic mice after treatment with insulin. | In mice with alloxan-induced diabetes, humoral and cellular immunological reactivity were weak. The number of leucocytes, and especially lymphocytes, was reduced, and the weight and cellularity of lymphatic organs were lower than in normal mice. Treatment of diabetic mice with insulin reversed morphological and functio... | 711,130 | [
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Changes in plasma amino acid levels during the human menstrual cycle and in early pregnancy. A preliminary report. | Fasting plasma amino acids have been measured in two normal females. In one subject changes in the levels of the amino acids have been followed weekly during four normal menstrual cycles. In the second subject changes in amino acid levels have been followed through a normal cycle, conception and early pregnancy. During... | 711,138 | [
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[Covalent C-terminal fixation of cyanogen bromide peptides in the liquid-phase-sequenator (author's transl)]. | This paper describes the covalent fixation and hydrophilisation of homoserin lactone peptides enabling complete C-terminal sequencing in the squenator. Dimethylformamide, dimethylsulfoxide and 6M guanidine hydrochloride in water were used as solvents, ethylendiamine, hexamethylendiamine and histamine base as amino comp... | 711,147 | [
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Inactivation of boar acrosin by peptidyl-arginyl-chloromethanes. Comparison of the reactivity of acrosin, trypsin and thrombin. | A survey of the reactivity of 16 peptidyl-argininyl-chloromethanes with boar acrosin indicated that these compounds as a general group of reagents were highly effective in the inactivation of acrosin since at least half of the reagents tested rapidly inactivated this protease at a concentration of 0.10 micrometer or lo... | 711,159 | [
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Crystalline [A21-desamido]bovine insulin. | [A21-Desamido]insulin is the major product formed during mild acid hydrolysis of bovine insulin at low insulin concentration. The derivative was isolated by standard procedures and its purity established by isoelectric focusing, disc electrophoresis and electrophoresis on cellulose acetate strips. The identity of the a... | 711,162 | [
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Collision carcinoma of the gastric cardia. | A case of squamous cell carcinoma of the lower end of the esophagus colliding with adenocarcinoma of the cardiac end of the stomach is reported. The rarity of the lesion, its diagnostic criteria, and therapeutic implications are briefly discussed. | 711,225 | [
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Localized congenital hepatic fibrosis presenting as an abdominal mass. | A six month old male with a liver mass localized to the right lobe that had the histological features of congenital hepatic fibrosis is presented. The mass was resected and the patient was asymptomatic 10 months after surgery. This case serves to further broaden the range of lesions with the histological features of co... | 711,226 | [
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Cardiac amyloidosis in hereditary neuropathic amyloidosis diagnosed by endomyocardial biopsy. | A 57 year old male first developed progressive neuropathy of the lower extremities and then similar involvement in the upper extremities. Two years later he developed dyspnea and then complete atrioventricular block requiring the use of a permanent cardiac pacemaker. An older brother had an almost identical clinical co... | 711,228 | [
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Infarction of the lymph nodes: a cause of a palisading macrophage reaction mimicking necrotizing granulomas. | A case of multiple cholesterol atheromatous emboli with infarction in various parts of the body is described. The histologic appearance of infarction in the lymph nodes, a rare condition, mimicked that seen in necrotizing granulomas usually secondary to micro-organisms. | 711,234 | [
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Long term post-traumatic retrograde corticospinal degeneration in man. | The spinal cord and brain of a man who died 18 years after a crush injury of lumbar segments contained some unusual lesions. There was a reduced number of myelinated axons in the corticospinal tracts as high as the fifth cervical segment. Such retrograde degeneration has been described in human pyramidal tracts only a ... | 711,235 | [
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Male pseudohermaphroditism: genetics and clinical delineation. | The genetics and clinical delineation of male pseudohermaphroditism are reviewed. These disorders are categorized initially by their genetic etiology--cytogenetic, Mendelian, or teratogenic. It is especially important to distinguish cytogenetic forms, usually associated with 45,X/46,XY mosaicism, from Mendelian (geneti... | 711,236 | [
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Correlation between intestinal synthesis of specific immunoglobulin A and protection against experimental cholera in mice. | The importance of locally and systemically formed antibodies of various classes for protection against experimental cholera has been studied in mice immunized with cholera toxin. Groups of mice were given various numbers of peroral or intravenous immunizations, or a combination of both. Serum antibodies and antibodies ... | 711,308 | [
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Morphological and cytochemical characterization of cells infiltrating mouse lungs after influenza infection. | To initiate evaluation of the cell-mediated immunological response to influenza virus in a major site of disease, lung cells were obtained by transpleural lavage from lungs of uninfected mice and from those infected 3 or 6 days previously with 5 50% mouse infectious doses (MID(50)) of avirulent (P3) or virulent (P9) in... | 711,312 | [
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Demonstration of three different subtypes of adenovirus type 7 by DNA restriction site mapping. | Restriction site mapping of the genomes of eight different isolates of adenovirus serotype 7 (Ad7) has been performed with six different restriction endonucleases. In this analysis, 37 different restriction sites were localized. Three distinctly different cleavage patterns of the genomes of the Ad7 strains were observe... | 711,317 | [
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Scanning electron microscopy of experimental Trichophyton mentagrophytes infections in guinea pig skin. | Trichophyton mentagrophytes invasion of guinea pig skin was examined by scanning electron microscopy. Biopsies were obtained daily for 12 days from experimental infection sites. Dermatophyte invasion, examined in detail by scanning electron microscopy of cross-sectioned, prefixed skin was evidenced by: the appearance o... | 711,318 | [
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Cross-protection in mice after immunization with H2N2, H3N2, and Heq2Neq2 influenza virus strains. | Mice were vaccinated with the influenza viruses A/Japan/57 (H2N2), A/Hong Kong/68 (H3N2), and A/Equi/Miami/63 (Heq2Neq2) and the hemagglutinin and neuraminidase recombinants derived from these viruses. After infection with the parent viruses, protection was compared with serological findings. It was found that influenz... | 711,325 | [
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Delayed hypersensitivity responses of experimental animals to histoplasmin from the yeast and mycelial phases of Histoplasma capsulatum. | Controlled yeast lysate (CYL) and controlled mycelial lysate (CML) histoplasmins were produced from Histoplasma capsulatum grown in a nutritionally lean, chemically defined medium. The lysates were assayed for skin-test activity in guinea pigs sensitized by infection with the homologous organism. In some studies, nonli... | 711,329 | [
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The management of hypertension associated with obesity. | For the past several decades, treatment of primary hypertension has relied chiefly upon the use of pharmacologic agents. Many hypertensive patients are obese. Evidence is accumulating that their hypertension may be reversed by aggressive and comprehensive regimens for weight reduction. Controlled studies are needed to ... | 711,366 | [
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Coacervation properties in sequential polypeptide models of elastin. Synthesis of H-(Ala-Pro-Gly-Gly)n-Val-OMe and H-(Ala-Pro-Gly-Val-Gly)n-Val-OMe. | Syntheses of two sequential polypeptides H-(Ala-Pro-Gly-Gly)n-Val-OMe and H-(Ala-Pro-Gly-Val-Gly)n-Val-OMe via the p-nitrophenyl active ester procedure are reported. The two polymers were obtained in good yields and the polymers were shown to be of large molecular weights, n greater than 40. These two polypeptides were... | 711,374 | [
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Purification and characterization of the surface active proteins of black gram (Phaseolus mungo). | The surface active globulin from black gram has been resolved into two components with high foam-forming activity. They were found to be homogeneous by electrophoresis and ultracentrifugal examinations and had high molecular weights around 100,000 daltons. They were rich in acidic as well basic amino acids but low in s... | 711,375 | [
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Inhibition of platelet aggregation by alpha-tocopherol and its nicotinate and acetate esters. | Two esters of vitamin E, dl-a-tocopheryl nicotinate and dl-a-tocopheryl acetate were found to be more inhibitors than tocopherol itself on platelet aggregation induced by arachidonic acid and collagen. The nicotinate was 1--5 times more potent than the acetate and 2--18 times more potent than the unesterified tocophero... | 711,383 | [
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Effect of enzyme combination and dialysis on amino acid patterns released from proteins. | Different combinations of gastrointestinal enzymes and dialysis altered amino acid yield and patterns released from proteins but did not negate the "variable ratio effect". That is, as substrate was increased relative to enzymes some amino acids increased, others decreased while still others were unchanged as a functio... | 711,388 | [
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Adrenergic innervation of the ureter. | To determine whether the ureter is innervated by the autonomic nervous system, isolated canine ureters were superfused with modified Tyrode solution, and force developed in response to 100-msec duration stimuli at a rate of 3 per min was monitored. Norepinephrine and phenylephrine significantly increased developed forc... | 711,404 | [
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Observation on the metabolism of iopanoyl (Telepaque) glucuronide in dogs treated with antibiotics. | The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chrom... | 711,400 | [
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Histology and ultrastructure of the R-3327 C-F transplantable prostate tumor of Cophenhagen-Fisher rats. | The R-3327 C-F tumor is an adenocarcinoma of the prostate maintained by serial transplantation in male Copenhagen-Fisher hybrid rats. The tumor is histologically different from other tumor sublines derived from the original R-3327 tumor discovered in 1961 in an aged Copenhagen rat. Light and electron microscopy have sh... | 711,418 | [
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[The testing of photochemotherapy in various dermatoses]. | Experimental PUVA therapy in five different skin diseases showed excellent results in lichen planus and pityriasis lichenoides et varioliformis. Present experience indicates a favourable influence of PUVA also in pityriasis rubra pilaris and in lymphomatoid papulosis. In Darier's disease PUVA leads to acute exacerbatio... | 711,446 | [
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Hypophosphatemia and hyperparathyroidism in a case of Bartter's syndrome. | In an 18-year-old boy with Bartter's syndrome, hypophosphatemia was discovered (2.4 mg/100 ml) with normal serum calcium concentration (9.7 mg/100 ml) and elevated alkaline phosphatase level: 528 mU/ml (normal less than or equal to 150). Skeleton X-rays showed osteomalacia on the pelvic bones and metaphyseal rickets on... | 711,493 | [
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Value of serum thyroxine measurements for the management of congenital hypothyroidism in children. | Fourteen cases of primary congenital hypothyroidism were studied and separated for the analysis purpose into two groups. Group A consisted of 7 children whose hypothyroidism was diagnosed after 1971 and the therapy by thyroid gland extracts evaluated by regular serum thyroid hormone determinations. Group B was made of ... | 711,496 | [
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Silver impregnation methods for reticulum fibers and reticulin: a re-investigation of their origins and specificity. | Maresch (1905) introduced Bielschowsky's silver impregnation technic for neurofibrils as a stain for reticulum fibers, but emphasized the nonspecificity of such procedures. This lack of specificity has been confirmed repeatedly. Yet, since the 1920's the definition of "reticulin" and studies of its distribution were ba... | 711,512 | [
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Concanavalin A receptors in normal and inflamed oesophageal epithelium. A light and electron microscopic study. | We have examined normal and inflamed oesophageal biopsies for the distribution of alpha-D-mannosyl and alpha-D-glucosyl residues using the concanavalin A--horse radish peroxidase--Diamino-benzidine (DAB) technique at the light and electron microscope level. Receptors were found on the epithelial surface and in the nucl... | 711,514 | [
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[Cortisol blood level in children with subglottic laryngitis (author's transl)]. | Clinical observations have shown that fear of suffocation aggravates respiratory tract occlusion in children with subglottic laryngitis (s.l.). In similar situations of emotional stress, changes occur in the function of the adrenal glands. The author's observations lead to the conclusion that rapid intravenous injectio... | 711,518 | [
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Mechanisms of pulsus paradoxus in upper airway obstruction. | Pulsus paradoxus, a greater than 10 Torr systolic pressure fluctuation during the respiratory cycle, is seen in upper airway obstruction. To test the hypotheses 1) that blood is pooled in the pulmonary circulation with reduced return to the left heart during inspiration and 2) that inspiration increases left ventricula... | 711,577 | [
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A simple technique for measuring alveolar CO2 in infants. | We designed a system consisting of a nostril adapter and a catheter for measurement of end-tidal ("alveolar") CO2 in small infants using the Beckman LB-1 analyzer. Using this system, we obtained a capillary-"alveolar" PCO2 difference (PaCO2-PACO2) of 2.4 Torr in 19 normal term infants, 3.5 Torr in 12 preterm infants wh... | 711,583 | [
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Evaluation of a transport medium for campylobacter (Vibrio) fetus. | A quantitative assessment was performed on a serum enrichment medium for Campylobacter (Vibrio) fetus, to test its effectiveness as a transport medium. Abundant yields of C fetus were obtained with an inoculum size of 10(4), even after keeping the medium in air at 22 to 23 C for 4 days prior to incubation at 37 C under... | 711,588 | [
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Clinical and clinicopathologic observations in induced malignant catarrhal fever of cattle. | In an epizootic of malignant catarrhal fever in 1976/1977 in southern California, 166 cows (17%) died. Blood from one of those cows was used in transmission studies involving 8- to 14-month-old steers. In 17 (74%) of 23 inoculated steers, the disease was reproduced. The clinical signs in 8 of the diseased steers were c... | 711,603 | [
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Acquired bilateral cortical cataracts in mature sows. | Bilateral cortical cataracts developed in approximately 30% of all sows greater than or equal to 2 1/2 years old on 4 farms in southwestern Ontario and on 2 farms in Quebec. A cataractogenic agent was not established, but hygromycin B was suspected as the cause. | 711,606 | [
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A new route to the synthesis of cyclitol derivatives. | Three cyclitol derivatives, 2,4/3-triacetoxycyclohexanone diethyl dithioketal (XVIII), and 2,3,4-tri-O-acetyl-1-O-ethyl-2,4/1,3-cyclohexanetetrol (XXA) and 2,3,4-tri-O-acetyl-1-O-ethyl-1,2,4/3-cyclohexanetetrol (XXB), have been synthesized via the cyclisation of 2,3,4-tri-O-acetyl-5,6-dideoxy-D-xylo-hex-5-enose diethyl... | 711,610 | [
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Carbon-13 nuclear magnetic resonance assignments of pactamycin and related compounds. | All resonances observed in the 13C NMR spectrum of the antitumor antibiotic pactamycin and its degradation product pactamyçate have been assigned, employing off-resonance and specific proton decoupling as well as comparison with the 13C NMR spectra of the model compounds m-aminoacetophenone and ethyl 6-methylsalicylate... | 711,622 | [
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Studies on the ionophorous antibiotics. XVI. The ionophore-mediated calcium transport and concomitant osmotic swelling of mitochondria. | The effects of various carboxylic ionophores on divalent metal cation translocation in mitochondria have been investigated. High levels of divalent cation ionophores lysocellin and lasalocid A (10 approximately 50 micrometer) produced mitochondrial osmotic swelling in Ca2+ or Mg2+ medium, which was associated with an i... | 711,630 | [
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Effects of cycloheximide and streptovitacin A on protein synthesis and gastric secretion in rats. | Cycloheximide and streptovitacin A administered in vivo to rats display a similar dual effect on the labelling of soluble liver proteins by valine-14C, and result in a similar enhancement of liver uridine kinase activity. On the other hand, in pylorus-ligated rats, both antibiotics markedly depress gastric secretion, a... | 711,632 | [
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A star-struck service: impact of the admission of a celebrity to an inpatient unit. | The celebrity shares features of the VIP or special patient. The celebrity, however, who refuses to remain anonymous within a hospital setting, often evokes more intense and even specific inappropriate reactions in those around him. His presence creates what the authors call the "star-struck phenomenon." The authors di... | 711,684 | [
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Oxygen exchange in silicone rubber capillaries. | Capillaries of 7 and 12.5 mu diameter have been fabricated in silicone rubber. Whole blood treated with heparin has been perfused through these capillaries. Under flowing conditions, no clotting or other clumping effects have been observed and red cells appear to maintain a constant velocity. Oxygen transfer data to an... | 711,713 | [
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Instrumentation for monitoring oxygen consumption using a replenishment technique. | An instrument to measure patient oxygen consumption simply and accurately has been built using a replenishment technique. Oxygen is added to the patient's exhaled gas until its oxygen concentration is the same as the oxygen concentration of the inhaled gas. The rate at which oxygen is added is a measure of the patient'... | 711,714 | [
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Aortic valve mechanics--Part I: material properties of natural porcine aortic valves. | A new methodology has been developed whereby the inhomogeneous and anisotropic aspects of an irregularly surfaced organ component have been incorporated in establishing the material properties of its tissue. Specifically the direction-dependent post-transition elastic moduli have been calculated from microtensile exper... | 711,721 | [
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A model for evaluating the ocular contusion injury potential of propelled objects. | The existing data on experimental ocular contusion were analyzed in terms of a simple mathematical model which predicts the maximum contact force between the eye and the impacting projectile. It was shown that this force was related to the injury producing mechanism, eyeball expansion, which was widely advocated in the... | 711,727 | [
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Analysis of the adult and embryonic chicken globin genes in chromosomal DNA. | Globin-specific mRNA has been purified from the red blood cells of anemic adult hens and from those of 5-day and 7-day chick embryos. These RNA preparations were used to synthesize labeled cDNA for solution and filter hybridization (Southern blotting) experiments. Hybridization of cDNAs prepared with separated adult al... | 711,749 | [
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The repair of cruciate ligaments with flexible carbon fibre. A longer term study of the induction of new ligaments and of the fate of the implanted carbon. | Carbon fibre appears to induce the formation of tendon in both animals and humans. Experiments have been conducted in sheep in which new anterior cruciate ligaments have been induced in response to the implantation of filamentous carbon fibre. Long-term studies indicate that the carbon fibre slowly breaks up at the sit... | 711,800 | [
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Estimation of adequate subendocardial blood flow by online computation of systolic pressure time index and diastolic pressure time index after cardiopulmonary bypass. | Subendocardial perfusion was monitored in 48 patients subjected to valve replacement by calculation of diastolic pressure time index (DPTI), systolic pressure time index (TTI) and DPTI/TTI. An on-line computer which derives these values from the systemic pressure and wave-form was applied. For myocardial protection gen... | 711,814 | [
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Human skin aryl hydrocarbon hydroxylase. Induction by coal tar. | Coal tar products, which are widely used in treating dermatologic disease, contain numerous polycyclic aromatic hydrocarbons, including 3,4-benzo[a]pyrene (BP). BP is among the most potent environmental chemical carcinogens and is known to evoke tumors in the skin of experimental animals and perhaps also of man. In thi... | 711,851 | [
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Surface markers of complement receptor lymphocytes. | Normal blood lymphocytes bearing complement receptors (CRL) were divided into two populations, one expressing both CR1 (C4b-C3b receptor) and CR2 (C3d receptor) and a second expressing only CR1. Nearly all of the population that expressed both CR1 and CR2 also bore membrane surface immunoglobulins (Ig) and Ia antigens.... | 711,854 | [
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Renin-angiotensin system inhibition in conscious dogs during acute hypoxemia. Effects on systemic hemodynamics, regional blood flows, and tissue metabolism. | The role of the renin-angiotensin system in mediating the circulatory and metabolic responses to hypoxia was studied in three groups of conscious dogs that were infused continuously with normal saline, teprotide (10 mug/kg per min), and saralasin (1 mug/kg per min), respectively. Hypoxia was produced by switching from ... | 711,860 | [
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Studies on the tubulo-glomerular feedback system in the rat. The mechanism of reduction in filtration rate with benzolamide. | The specific mechanism whereby superficial nephron glomerular filtration rate (sngfr) is reduced after the administration of benzolamide, a carbonic anhydrase inhibitor with a primary inhibitory effect in the proximal tubule, have been examined by measuring pertinent pressures, flows, and glomerular permeabilities in t... | 711,863 | [
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-0.1590368,
-0.267681,
0.01979751,
-0.5068012,
0.1015086,
0.2478669,
0.2332405,
-0.09899235,
... |
Demographic and clinical characteristics as predictors of readmission: a one-year follow-up. | Follows up an earlier investigation in which demographic and clinical characteristics of psychiatric patients were used to predict readmission within 3 months of discharge. In the initial study, stepwise multiple regression analysis identified six variables as the optimal set of predictors for readmission within 3 mont... | 711,870 | [
-0.1624469,
-0.04411246,
-0.273871,
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0.007867265,
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0.3725565,
0.2518065,
0.3830709,
-0.00443374,
-0.3436249,
0.1905953,
-0.15958... |
The use of the Goldberg Indices with alcoholics: a cautionary note. | Applied Goldberg's (1972) regression equation for the classification of MMPI profiles to the MMPI profiles of 173 alcoholic male veterans. All Ss also completed a detailed alcoholic life history questionnaire. It was hypothesized that there would be differences between the life history responses of those Ss classified ... | 711,897 | [
-0.1193612,
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0.1753189,
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0.05411332,
0.03367451,
0.1641831,
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0.07980103,
0.2364672,
0.2704291,
0.10897,
0.355316,
-0.08245658,
0.01421666,
-0.006187099,
0.2338108,
0.1329442,
-... |
An improved method for the diagnosis of polycythaemia. | The red cell mass was measured in 44 normal subjects and showed a closer correlation with total body water or surface area than with body weight. The results obtained in a group of patients with polycythaemia, however, still overlap with the normal range. When the total number of circulating red cells is measured these... | 711,904 | [
-0.2046146,
0.1251021,
-0.209808,
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0.04796733,
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0.07236633,
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0.07991118,
0.1218878,
0.0168498,
0.222045,
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0.0805421,
-0.1727101,
0.2015187,
0.2728617,
0.008400436,
-0.1027482,
0.237... |
Hemodynamic effects of morphine in cardiac disease. | The hemodynamic effects of intravenous morphine were documented by right heart catheterization in six patients with an acute uncomplicated transmural myocardial infarction one to three days after the onset of symptoms. Intracardiac pressures, brachial artery pressure, and cardiac output were determined before and 15 mi... | 711,925 | [
-0.2274024,
0.01163183,
-0.5057604,
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0.08669944,
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0.1520348,
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-0.06146196,
0.262787,
0.06875747,
-0.07740671,
0.2451063,
-0.03663978,
0.19... |
Computed tomographic diagnosis of pseudoascites (floating viscera syndrome). | Two cases of excessive fat deposition in the abdomen, confused clinically as massive ascites, are reported. Computed tomography (CT) has proven useful in making a definitive diagnosis of fat deposition in the abdominal and retroperitoneal space and has made further clinical studies unnecessary. No prior cases of pseudo... | 711,946 | [
-0.08410436,
0.2350165,
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0.03529702,
0.1068309,
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0.1721438,
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0.2037432,
0.04172764,
-0.3601204,
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0.06036013,
-0.1681374,
... |
Intraventricular hemorrhage in blunt head trauma. | A series of 200 computed tomography (CT) scans performed for blunt head trauma was reviewed. Six patients were found to have clearly definable intraventricular hemorrhage (IVH); in three cases no other CT abnormality was noted. Computed tomography represents the only noninvasive method of detecting IVH, and the inciden... | 711,952 | [
-0.1402504,
0.2561644,
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0.1642016,
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0.3050821,
0.2557345,
0.09173854,
-0.2962739,
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-0.201213,
0.5100899,
0.0871428,
0.1216461,
0.2857077,
0.1663649,
0.01874221,
-0.... |
Effect of environmental factors and fetal and maternal genotype on gestation length and birth weight of Holstein calves. | Records of gestation length and birth weight on 1522 live single births (from 1958 to 1976) of Holstein calves were from 81 sires and 552 dams. Average gestation length was 282.3 days, and average birth weight was 42.9 kg. Male calves were carried 1.7 days longer than female calves and weighed 2.9 kg more at birth. Bot... | 711,962 | [
0.194358,
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0.2158497,
0.1534039,
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0.0776971,
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0.1554357,
0.0473752,
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0.04767623,
0.1967302,
0.1526802,
-0.03058632,
-0.1757408,
0.2699498,
-0.09287891,... |
Carcinoma of the breast in East Anglia 1960-1975: a changing pattern of presentation? | A study was made of the clinical stage at presentation in 10 081 cases of carcinoma of the breast registered with the East Anglian Cancer Registration Bureau between 1960 and 1975. Information about the length of clinical history was obtained in 8862 cases. There has been a gradual increase in the population-adjusted i... | 711,976 | [
0.05223574,
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0.02871276,
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-0.3961532,
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0.05032156,
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0.4308175,
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0.0823423,
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0.2405784,
0.1891139,
0.4549722,
-0.2377952,
0.4809665,
0.3977866,
-0.1184336,
0... |
Behavioral, compound action potential, and single unit thresholds: relationship in normal and abnormal ears. | Comparisons were made for two species (chinchilla and mongolian gerbil) among mean behavioral audiogram, mean just detectable action potential (AP) responses to tone bursts, and single-fiber response thresholds at the characteristic frequency, averaged in one-octave bands. In normal animals and in a group of Kayamycin-... | 711,993 | [
0.03146681,
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0.09807409,
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0.07278004,
0.05404207,
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0.08513165,
-0.04920182,
0.4451976,
-0.1841813,
0.1004943,
-0.730949,
0.3410957,
-0.1278754,
0.1372522,
0.3721468,
0.002233275,
0.1035121,
... |
Indirect assessment of the contribution of subglottal air pressure and vocal-fold tension to changes of fundamental frequency in English. | The contributions of vocal-fold tension and of subglottal air pressure to changing fundamental frequency F0 are indirectly assessed by comparing human glottal-source data with synthetic glottal waveforms generated by the Ishizaka-Flanagan two-mass model of vocal-fold vibration. In this model, synthetic male and female ... | 712,003 | [
-0.3613291,
-0.1921533,
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0.2136122,
-0.2488886,
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0.4069243,
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0.09898859,
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0.1083069,
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-0.04201138,
-0.1509262,
-0.4913403,
-0.167901,
0.05232663,
0.1924839,
-0.0562753... |
Strength of the pitches associated with ripple noise. | A discrimination procedure was used to measure the pitch strength of the repetition pitches associated with comb-filtered or ripple noise. Pitch strength was measured as a function of overall ripple noise level, the repetition pitch of the noise, and as a function of the center frequency of 1/3-octave bandpass filtered... | 712,010 | [
0.02013382,
0.07788222,
0.1243461,
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0.05121676,
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0.3120424,
-0.04931673,
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0.0745205,
0.1574809,
0.02630903,
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-0.399327,
0.1376641,
-0.09486268,
-0.1144199,
0.4119211,
-0.1852971,
-0.1442567,... |
Intensity perception. IX. Effect of a fixed standard on resolution in identification. | This note reports some measurements of the changes in identification performance that result form presenting a fixed standard before each trial. These measurements indicate that the presence of the standard improves performance for test stimuli in the vicinity of the standard, except when the standard is near the extre... | 712,014 | [
-0.1212847,
0.1259642,
-0.2251472,
-0.06027921,
0.1158066,
-0.115818,
-0.4472328,
0.08279357,
0.2443629,
-0.3024628,
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0.04504087,
-0.1257699,
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-0.2083182,
-0.4050056,
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-0.2584425,
0.2958723,
-0.1069021,
0.1263265,
0.04754303,
... |
Two determinants of localization acuity in the horizontal plane. | An attempt was made to extend the auditory localization model of Searle, Braida, Davis, and Colburn [J. Acoust. Soc. Am. 60, 1164-1175 (1976)] to regions beyond the fontal horizontal plane. On the basis of two experiments, it appears that the assumption of acuity independent of angle is not valid for these more extensi... | 712,015 | [
-0.05501245,
-0.2652877,
-0.1462128,
0.02054329,
0.08976149,
-0.4319273,
-0.08505152,
-0.01321362,
0.3091154,
-0.03443138,
0.05570991,
-0.2680181,
-0.025077,
0.08687611,
0.1326332,
-0.07778441,
-0.3494469,
0.08043408,
-0.1693716,
-0.2575985,
0.3169281,
0.02669724,
0.15443... |
[Contraception before pregnancy. Evolution between 1972 and 1975 in the Rhone-Alpes region (author's transl)]. | The studies was made from two enquiries carried out on women who delivered in June 1972 and 1975 in the Rhone-Alpes region. Contraception therefore dealt exclusively with birth control before a pregnancy. It is clear that contraception has developed significantly: it is practised by 48% of women who were questioned in ... | 712,039 | [
-0.08334605,
0.3980213,
0.0726916,
0.08737799,
0.2823223,
-0.3816991,
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-0.2258383,
0.1314963,
0.1816796,
0.04869539,
-0.05158677,
-0.01731918,
-0.02010542,
-0.8413585,
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0.1156574,
-0.02934678,
0.3387706,
0.5477966,
0.03648047,
-0.08133151,... |
[The antepartum oxytocin fetal assessment challenge test 1,827 case histories. Significance of "prepathological testing". "Results" (author's transl)]. | We carried out the Oxytocin Challenge Test (or OCT as American authors call it) by injecting 5 m.U. per minute into pregnant women who are suspect of having high fetal risk from the 34th week of pregnancy onwards. The material that we have examined is from 1,366 cases with 1,827 tests. The perinatal mortality over all ... | 712,044 | [
-0.006551799,
-0.3481894,
-0.1462994,
0.1021624,
0.2884575,
-0.261659,
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0.1466583,
0.1476636,
-0.1955399,
0.04550991,
0.2964726,
0.140284,
0.2384045,
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0.3353946,
0.1114464,
0.2046044,
0.5914232,
0.0985693,
-0.1068161,
0.0775... |
Membrane proteins of the P388D1 macrophage cell line: isolation of membrane polypeptides that bind to the Fc portion of aggregated IgG. | Lactoperoxidase-catalyzed cell surface radioiodination was employed to radiolabel membrane polypeptides of a murine macrophage cell line P388D1. Optimal conditions for radioiodination of P388D1 cells were determined and were found to differ from conditions used to label lymphoid cells. SDS-polyacrylamide gel electropho... | 712,075 | [
-0.1088131,
-0.1787568,
0.05248229,
0.06450094,
0.04437429,
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-0.2189253,
0.0374614,
0.1754395,
0.1970201,
0.06678331,
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0.2583777,
0.1031741,
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-0.2270831,
0.02719648,
0.284961,
-0.2039879,
0.2547524,
-0.04045285,
... |
Effect of occlusion on Trichophyton mentagrophytes infections in guinea pigs. | The effect of occlusion and griseofulvin on the duration and severity of acute dermatophytosis was assessed in guinea pigs. Sixty guinea pigs given standard Trichophyton mentagrophytes infections were divided into 5 groups: (A) control, (B) intermittent wet occlusion, (C) continuous-wet occlusion, (D) griseofulvin, (E)... | 712,105 | [
0.3598156,
0.07993536,
0.1917429,
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0.4820765,
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0.144375,
0.1495205,
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-0.3679759,
-0.1066652,
0.1849193,
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0.125913,
0.1205931,
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-0.3590092,
0.3294523,
-0.03769029,
-0.02360363,
-0.03738355,
0.3239334,
-0.1121524,
0.... |
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