title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Intravenous antibiotic therapy at home. | During a 12-month period, 23 patients aged 12 to 78 years were treated for 8 to 40 days (mean, 23 days) at home with intravenous (i.v.) antibiotics. Diseases treated included bone and joint infection (14 patients), blastomycosis (two), actinomycosis (two), staphylococcal bacteremia (two), endocarditis (two), and candid... | 717,941 | [
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Constraints under which the microbiology laboratory functions. | The relevance, usefulness, quality, and cost of performance of many clinical microbiology laboratories have been questioned. Major, common constraints under which most microbiology laboratories operate in the United States include lack of trained manpower, wide variation in the level and sophistication of clinical micr... | 717,954 | [
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Problem of antibiotic usage. Definitions, causes, and proposed solutions. | Standardized surveillance methods are needed in order to obtain valid comparison among institutions concerning use of antimicrobial agents. These include use of data from the hospital pharmacy and review of routine orders for propolyaxis in surgery and for specific infectious diseases. Audits of individual agents shoul... | 717,959 | [
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[Experimental infection in mice with Yersinia enterocolitica (strain biotype 4, serogroup O:3, phage type VIII): growth of the inoculum in athymic or cyclophosphamide treated mice (author's transl)]. | Intravenous infection of Swiss mice with a strain of Yersinia enterocolitica unable to colonize normal mice by the oral route, induced a systemic infection. Viable bacteria were isolated from homogenates of liver, spleen and lungs, as early as one hour after the challenge and have been detected during two weeks. On the... | 718,016 | [
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[Chronic otitis in the one remaining functional ear: therapeutic problems and sequelae (author's transl)]. | What should one do when a patient presents with a potentially dangerous chronic otitis, and the other ear is absent? An analysis of such dangerous cases with a cholesteatoma, more especially those with a labyrinthine fistula. Responsibility has to be taken. Medico-legal problems are evoked. | 718,049 | [
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Control of road trauma epidemic in Australia. | This lecture discusses initiatives taken by the Road Trauma Committee of the Royal Australasian College of Surgeons to reduce fatality and injury on Australian roads. In 1970 the Road Trauma Committee and the communications media initiated a national campaign in support of legislation for the compulsory wearing of seat... | 718,071 | [
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Prostatic cysts. | The classification, clinical features, and treatment of prostatic cysts are discussed with reference to 2 personal cases which differed in origin, in mode of presentation, and in the management required. | 718,076 | [
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Evaluation of a kit for the colorimetric determination of inorganic phosphate. | An evaluation of a colorimetric kit method for the determination of inorganic phosphate (Pierce Phosphorus Auto/Stat Kit) is described. The within-batch and between-batch precisions were shown to fulfil current criteria, and recovery experiments, linearity studies, analyses of quality control materials, and studies of ... | 718,109 | [
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Dealing with specimen problems in a computerised clinical chemistry laboratory. | The use of a laboratory computer system to deal with specimen problems is described. Problems such as 'insufficient material' or 'haemolysis' are entered by reception staff or by bench workers so that resolution of the problem will not be overlooked; problems are then listed and dealt with by the duty biochemist. Speci... | 718,111 | [
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Sparing of the Onufrowicz nucleus in sacral anterior horn lesions. | Sacral anterior horns were examined with special reference to the Onufrowicz nucleus in 3 patients with Werdnig-Hoffman disease, 2 with healed anterior poliomyelitis, and 1 who had undergone amputation of both legs above the knee. None of these patients showed symptoms of either urethral or anal sphincter disturbances.... | 718,135 | [
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Brain dopamine receptor stimulation and the relief of Parkinsonism: relationship between bromocriptine and levodopa. | The relationship between dopamine receptor stimulation by bromocriptine or levodopa and the relief of parkinsonism was studied in 24 patients with Parkinson disease. Bromocriptine, 30 mg daily for 20 weeks, elicited an improvement in the parkinsonian clinical features, but this was less than the subsequent improvement ... | 718,139 | [
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[Aspects of the therapeutic action of proteolytic enzymes and antibiotics in experimental staphylococcal infection. The effect of lincomycin, chymotrypsin and their combinations on leukocyte phagocytic activity]. | The effect of leucomycin, chimotrypsin and their combination on the leucocyte phagocytic activity was studied on mice with experimental staphylococcal infection. Lincomycin and chimotrypsin were administered in doses of 150 and 2 mg/kg respectively. In the study of the leucocyte phagocytic activity it was found on the ... | 718,145 | [
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[Sensitivity study of dog kidney membrane-bound ribosomes to the action of amphotericin B in vitro]. | The effect of amphotericin B on the number of the ribosomes bound with the endoplasmic membranes in the dog kidney cells was studied in vitro. The binding of the ribosomes was evident from the RNA/protein ratio. It was found that the RNA/protein ratio in the rough membranes treated with amphotericin B in a concentratio... | 718,146 | [
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Pilar sheath acanthoma. | A newly recognized, benign follicular tumor occurred in nine patients who ranged in age from 46 to 75 (median, 55) years. The neoplasms were solitary, asymptomatic, skin-colored nodules with a central pore-like opening plugged with keratin. All lesions had been present for years. Eight were on the skin of the upper lip... | 718,186 | [
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Malignant atrophic papulosis: treatment with aspirin and dipyridamole. | On electron microscopy of the endothelial cells of a patient with cutaneous and CNS symptoms of malignant atrophic papulosis, paramyxovirus-like particles could be seen in the cytoplasm. These particles were interpreted as degenerative changes that were due to ischemia. Coagulation studies showed increased thrombocyte ... | 718,220 | [
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House dust mite sensitivity in childhood asthma. | The clinical features of perennial asthmatic children with a skin or bronchial reaction to the house dust mite (Dermatophagoides pteronyssinus) were compared with those of asthmatic children without mite sensitivity. Mite sensitive asthma was characterised by an early age of onset of symptoms, these being predominantly... | 718,239 | [
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An ultrastructural study of localized lymphangioma circumscriptum. | An electron microscopic study was performed on the lymphatic vessel (lv) of localized lymphangioma circumscriptum (Lc), which was found clinically typical but histologically not associated with hemangioma and inflammation. The lv of Lc was morphologically divided into two types. The first type was situated at the upper... | 718,256 | [
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Comparative electron microscopic study of clear cells in epidermodysplasia verruciformis and flat warts. | Are Epidermodysplasia verruciformis (E.V.) and disseminated flat warts different diseases? Are there any diagnostic criteria between them? In order to attempt answering these 2 questions, fundamental for prognosis and nosology, a comparative ultrastructural study was made of epidermal clear cells of 2 cases of E.V. and... | 718,259 | [
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Gallium citrate Ga 67 imaging in noninfectious interstitial nephritis. | Gallium citrate Ga 67 has been reported to be of value in the diagnosis of both malignant and infectious intra-abdominal diseases. The drug may also be taken up by mononuclear phagocytes in noninfectious tubulo-interstitial disease of the kidney. Positive renal scans from patients with these diseases either become nega... | 718,315 | [
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Pseudomonas maltophilia causing heroin-associated infective endocarditis. | The association of Pseudomonas maltophilia endocarditis in three patients with recent history of intravenous drug abuse is reported. All three patients had abnormal heart valves (two prosthetic and one rheumatic). A prominent characteristic of this uncommon pathogen is its in vitro resistance to the commonly used antim... | 718,316 | [
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The syndrome of inappropriate antidiuretic hormone secretion in multiple sclerosis. | The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) occurred during an excerbation of multiple sclerosis (MS). Rapid symptomatic improvement occurred with correction of the hyponatremia. Although the pathophysiology responsible for development of the SIADH in this patient is unknown, CNS involvement... | 718,325 | [
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Necrotizing fasciitis associated with Haemophilus aphrophilus. Report of a case. | Necrotizing fasciitis, a serious infection requiring prompt antibiotic and surgical therapy, previously has not been associated with Haemophilus aphrophilus. We report a case of necrotizing fasciitis associated with methylphenidate abuse from which H aphrophilus was isolated. Surgical and antibiotic therapy based on in... | 718,326 | [
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Frequency and morbidity of invasive procedures: report of a pilot study from two teaching hospitals. | The medical services of two teaching hospitals were assessed for the frequency of and complications from invasive procedures. There were 231 procedures performed on 303 patients. The frequency of procedures was significantly higher at one hospital (62% vs 39%, P less than .01). Twenty-nine complications occurred in 20 ... | 718,346 | [
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Screening for lignin degrading bacteria by means of 14C-labelled lignins. | Several Nocardia and Pseudomonas spp., as well as some unidentified bacteria, isolated from lake water containing high loads of waste lignin, were tested for their capacity to release 14CO2 from specifically 14C-labelled dehydropolymer of coniferyl alcohol (DHP) or corn stalk lignins. The bacteria were selected accordi... | 718,367 | [
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Marital sexual enjoyment and frustration of professional men. | The psychological maturity, interpersonal, and marital attributes associated with the sexual pleasure and frustration of 59 married professional men, who had also been studied as adolescents, were examined by means of 10--12 hr of psychological tests, questionnaires, and interviews. The men's wives, closest friends, an... | 718,416 | [
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Meningeal sarcoma of the spinal cord in a newborn. | In a newborn infant, spinal rigidity and signs of cervical cord compression developed. Myelography suggested the presence of a spinal cord neoplasm, and pathologic studies confirmed the diagnosis of a pleomorphic cellular sarcoma originating from the leptomeninges of the thoracic spinal cord. A review of neonatal spina... | 718,489 | [
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Morphological appearance of the healing corneal endothelium. | We studied endothelial cell patterns in both the central and the superior regions of the cornea in 43 cases of cataract extraction and intraocular lens implantation. During the early postoperative period, the central endothelial cells maintained their preoperative appearance. The endothelium within 3 to 4 mm of the sup... | 718,490 | [
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Cavernous hemangioma of the retina. | Cavernous hemangioma of the retina is recognized as a distinct clinical entity. Although neurocutaneous findings are sometimes associated with these retinal tumors, in most of the cases reported to date, systemic features have not been described. This report describes two patients with cavernous hemangioma of the retin... | 718,493 | [
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Subretinal neovascularization associated with fundus flavimaculatus. | Hemorrhagic disciform degeneration centered in the fovea with serous detachment of the overlying neuroepithelium developed in two patients with fundus flavimaculatus. Fluorescein angiography disclosed the presence of subretinal neovascular membranes. There was no evidence of other diseases associated with subretinal ne... | 718,494 | [
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0.06664945,
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False-positive 32P uptake tests. | Three patients had suspected choroidal melanoma and positive results for radioactive phosphorus (32P) uptake tests, leading to enuclearion in two of the patients. No malignancy was present on histopathologic examination. This experience reemphasizes the need for the ophthalmologist to evaluate the total clinical pictur... | 718,516 | [
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... |
Effects of number and interstimulus interval of tone pips on fast responses. | Effects of stimulus number and interstimulus interval on auditory-evoked fast responses (BSR: Jewett's V, and middle-latency components: Na, Pa and Nb) were studied by using 1000- and 500-Hz tone pips in 6 normal human adults. At a stimulus intensity of 50 dB SL, 500 stimuli evoked BSRs and the middle-latency component... | 718,539 | [
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Immunity to experimental staphylococcal mastitis--comparison of live and killed vaccines. | Eleven pregnant Merino ewes were immunised with either a killed Staphylococcus aureus cell-toxoid vaccine (intramuscularly) or a living culture of the same organism (subcutaneously). A further 3 animals were used as non-immunised controls. There were no significant differences between the vaccinated groups for agglutin... | 718,556 | [
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0.2531339,
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Motion sickness susceptibility: a retrospective comparison of laboratory tests. | A test battery designed primarily to assess vestibular function has been used for several years to evaluate individuals referred to our laboratory. Because some of the test conditions have proved to be nauseogenic to some individuals, methods of assessing disturbance during these procedures have been used to pursue a s... | 718,570 | [
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0.1132869,
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Blood volume and cardiorespiratory responses to lower body negative pressure. | Breath-by-breath measurements of pulmonary capillary O2 transfer and ventilation were made on three subjects during and after 10 min of lower body negative pressure (LBNP) at -20, -40, and -60 torr. Loss in blood O2 stores (O2B) during and replenishment after LBNP were directly related to the intensity of LBNP. The pea... | 718,573 | [
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0.1005323,
... |
Intracardial gas bubbles and decompression sickness while flying at 9,000 m within 12-24 h of diving. | Intracardial gas bubbles, detected with Doppler ultrasound, and symptoms of decompression sickness were registered at 9,000 m simulated altitude within 12, 18, and 24 h of exposures to 15 or 39 m simulated water depth allowing no stage decompression. With a time interval of 12 h between diving and flying, the earliest ... | 718,575 | [
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0.08296078,
0.3858681,
0.02680... |
Wolff-Parkinson-White syndrome (type A) complicated by heart block in both normal and accessory pathways. | A 67-year-old man with Wolff-Parkinson-White syndrome type A presented with second degree atrioventricular block in anomalous pathway and complete infra-Hisian block in the His-Purkinje pathway. He had increasingly frequent attacks of dizziness not related to exercise. A permanent ventricular demand pacemaker was succe... | 718,775 | [
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Effect of certain anaesthetic agents on the activity of rat hepatic delta-aminolaevulinate synthase. | The activity of delta-aminolaevulinic acid synthase (E.C.2.3.1.37) (the rate-limiting enzyme for haem and porphyrin biosynthesis) has been measured in the rat liver after the repeated administration of anaesthetic agents in vivo. The activity of the enzyme was increased by Althesin, chlordiazepoxide, enflurane, etomida... | 718,778 | [
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0.446856,
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0... |
Light and electron microscope studies of the rat digestive tract following prolonged and short-term ingestion of chrysotile asbestos. | Rats were fed diets containing 0.5 mg or 50 mg of chrysotile asbestos each day for 1 week or 14 months and tissues of the gastrointestinal tract were examined by light and electron microscopy. At the light microscope level the oesophagus, stomach and caecum in treated animals appeared unaffected, whereas accumulation o... | 718,798 | [
-0.07827284,
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0.2417686,
0.1234685,... |
Surgery of congenital and juvenile cataracts: a pars plicata approach with the vitrophage. | Eighteen eyes with congenital cataracts were surgically managed by pars plicata lensectomy and vitrectomy using the vitrophage. No major intraoperative or postoperative complications were encountered. All eyes have maintained extremely clear media, attached retinas, and absence of pupillary block during a follow-up per... | 718,818 | [
0.1551993,
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0.1235088,
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0.5569938,
0.1994201,
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0.127... |
Aspiration from the vitreous of a non-magnetic foreign body. | A non-magnetic vitreal foreign body was aspirated from over the macula through the pars plana. The surgeon guided a blunt needle towards the foreign body while watching both with the binicular indirect ophthalmoscope. His assistant's tentative suction movements with an attached syringe drew the foreign body up into the... | 718,819 | [
-0.4031104,
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0.009327028,
0.1382519,
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0.2044529,
-0.01076003,
0.0202509... |
Generalized equations for predicting body density of men. | 1. Skinfold thickness, body circumferences and body density were measured in samples of 308 and ninety-five adult men ranging in age from 18 to 61 years. 2. Using the sample of 308 men, multiple regression equations were calculated to estimate body density using either the quadratic or log form of the sum of skinfolds,... | 718,832 | [
-0.02807254,
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0.09906778,
0.1405056,
0.2174453,
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Effect of vitamin B12 deficiency on phosphatidylethanolamine methylation in rat liver. | 1. In vitamin B12 deficiency the activity of tetrahydropteroylglutamate methyltransferase (EC 2.1.1.13) is depressed and the synthesis of methionine is reduced. Because the methyl group of methionine is largely utilized for the methylation of phosphatidylethanolamine, we investigated the effects of vitamin B12 deficien... | 718,835 | [
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0.4687148,
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Kinetics of substrate and product interactions with arsanilazotyrosine-248 carboxypeptidase A. | The chromophoric intramolecular azoTyr-248.Zn complex detects discrete kinetic steps in the interaction of azocarboxypeptidase with products or substrates that are hydrolyzed slowly. Temperature-jump experiments at 510 nm indicate that the rapid binding of such ligands is followed by a slower change in the conformation... | 718,842 | [
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-... |
Nucleosome structure of Xenopus oocyte amplified ribosomal genes. | The chromatin subunit or nucleosome structure of the amplified, extrachromosomal, ribosomal genes of oocytes of the amphibian Xenopus laevis has been investigated during stages of growth when these genes are markedly changing their rates of transcriptional activity. Nucleic acid hybridization studies involving micrococ... | 718,864 | [
0.2952955,
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... |
Circular dichroism of squid rhodopsin and its intermediates. | Circular dichroism (CD) and absorption spectra of squid (Todarodes pacificus) rhodopsin, isorhodopsin and the intermediates was measured at low temperatures. Squid rhodopsin has positive CD bands at wavelengths corresponding the alpha- and beta-absorption bands at liquid nitrogen temperature (CD maxima: 485 nm at alpha... | 718,881 | [
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0.224518,
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0.01... |
The adsorption of divalent cations to phosphatidylcholine bilayer membranes. | Electrophoretic mobility and 31P NMR measurements were combined to test whether the combination of the Henry, Boltzmann and Grahame equations is capable of describing the adsorption of divalent cations of phosphatidylcholine membranes. Cobalt was chosen for this study because, of all the common divalent cations, its ef... | 718,897 | [
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0.025... |
Separation of the proteins of bovine milk-fat globule membrane by electrofocusing. | The proteins of milk-fat globule membrane have been separated by electrofocusing on both the analytical and preparative scale. Over forty separated proteins of the membrane can be identified after electrofocusing in the presence of urea, Triton X-100 and mercaptoethanol with apparent isoelectric points between pH 5.0 a... | 718,905 | [
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The moderately repetitive DNA sequences of Caenorhabditis elegans do not show short-period interspersion. | In these studies we show that the moderately repetitive DNA sequences of Caenorhabditis elegans are not arranged in the characteristic short-period interspersion pattern of most eukaryotes. Rather, the moderately repetitive sequences are arranged in long arrays as in Drosophila and Apis. These findings indicate that th... | 718,922 | [
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0.0393298,
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Nuclear chromatin changes during post-natal myocardial development. | The proliferative capacity of rat myocardium declines rapidly during the first few weeks of post-natal life. In order to gain insight into the mechanisms involved in this decline, we studied the structure and function of nuclear chromatin from isolated rat myocardial cells during post-natal growth. Chromatin template a... | 718,935 | [
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A fast evaluation of diffusion effects on bound enzyme activity. | As the kinetic behavior of bound enzymes is frequently affected by substrate diffusion between the bulk solution and the catalytic sites, a fast and simple method is proposed to detect and, subsequently, to remove diffusion effects on measured enzymic activities. The procedure makes use of the effectiveness factor conc... | 718,939 | [
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Presence of a single enzyme catalyzing the pyrophosphorolysis of UDP-glucose and UDP-galactose in Bifidobacterium bifidum. | The enzyme preparation catalyzing the pyrophosphorolyses of UDP-glucose and UDPgalactose almost at the same rate was purified about 900-fold from Bifidobacterium bifidum grown on glucose medium. The two activities were always associated with each other, and their activity ratio was always constant throughout the purifi... | 718,964 | [
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0.5472892,
0.4527261,
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Comparison of C18-, C20- and C22-unsaturated fatty acids in reducing fatty acid synthesis in isolated rat hepatocytes. | C18-, C20- and C22-unsaturated acids were tested for inhibition of fatty acid synthesis in hepatocytes isolated from essential fatty acid-deficient rats. Fatty acid synthesis was measured by incorporation of radioactivity from [1-14C-A1-acetate or 3H2O into fatty acids. C20-polyunsaturated fatty acids included arachido... | 718,967 | [
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0.2290515,
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Effects of bile salts on the structural integrity of liposomes. | The effects of the bile salts, sodium taurocholate and sodium glycocholate on the structural integrity of liposomes of different lipid compositions were studied. The bile salt concentrations were in the range encountered in the human intestine and the incubations were conducted at 37 degrees C. Two measures of liposome... | 718,987 | [
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Studies on the cytochrome P-450 product complexes formed during the metabolism of N,N-dimethylaniline. | The oxidative metabolism of N,N-dimethylaniline by partially solubilized cytochrome P-450 from rabbit liver was found to be associated with the formation of a 424- and 448-nm product adduct of the hemoprotein. From the effects of temperature, hydrogen ion concentration, n-octylamine, extraction of the enzyme preparatio... | 718,995 | [
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0.3465149,
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Bovine adrenocortical microsomal hydroxylase and thermotropic transition. Substrate-cytochrome P-450 binding reaction versus substrate hydroxylation. | The effect of temperature on steroid C-21 hydroxylation and substrate-cytochrome P-450 binding reaction under turnover conditions (NADPH + O2 are investigated. The Arrhenius activity plot exhibited a single break, while the van 't Hoff plot of the substrate dissociation constant (Ks) exhibited four breaks between 10 an... | 719,007 | [
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... |
[Application of autocorrelation analysis to the study of conformational changes in chloroplasts]. | The process of conformational oscilations of chloroplasts has been studied using autocorrelation analysis technique. The process is shown to differ from the non-correlated random process of "white noise" type. Four types of autocorrelogram have been obtained which are characteristic of the phone oscilations of chloropl... | 719,017 | [
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0.0382993,
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0.00424183,
0.3855061,
0.2065166,
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0.002... |
Glucose transport by horse kidney brush borders. I.--Transport properties of brush border membrane closed vesicles. | Brush border membranes isolated from horse kidney cortex as closed right-side out vesicles show selective permeability when analyzed on sucrose and dextran gradients. These vesicles can actively accumulate D-glucose. The preservation of the glucose transport system is demonstrated by the following features: (a) the upt... | 719,044 | [
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0.2094303,
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[Biospecific chromatography of poly(A)-containing RNA on poly(U)-Sepharose]. | It is shown that in addition to specific binding of polyadenylic sequence with poly(U), the chromatography of poly(A)-containing RNAs on poly(U)-Sepharose is accompanied by nonspecific irreversible adsorption of polynucleotides on Sepharose gel. This disadvantage may be overcome by establishing optimal BrCN/Sepharose r... | 719,052 | [
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0.1101888,
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[Nuclease activity of the cytoplasmic ribosomes of hepatocytes and several experimental hepatomas]. | The nuclease activities of proteins, constituents of cytoplasmic ribosomes obtained from normal liver rats (Wistar) and C3HA mice as well as from hepatomas (both solid and ascites forms) transplanted into the above animals, were studied. RNA in membrane-bound ribosomes of normal rat liver incubated at 37 degrees C unde... | 719,053 | [
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[Effect of chemical modification of the surface of erythrocytes on their stability to the hemolytic action of sodium alkyl sulfates]. | The hemolytic action of a homologous series of sodium alkyl sulfates (C8 to C15) on dog and human erythrocytes was measured. The influence of trypsin, pronase and neuraminidase treatments on the lytic resistance of human red cells was studied. A new approach evaluating the hemolytic activity of ionic surfactants is exp... | 719,073 | [
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... |
Defective microbicidal function of neutrophils in haematological malignancies and lymphomas: correction by levamisole in vitro. | The ability of neutrophils to kill Candida guilliermondii was investigated in patients with various haematological malignancies and lymphomas. Twelve of 24 patients showed significant depression of Candida killing in vitro in comparison with normal controls. The addition of levamisole to the test system, in a concentra... | 719,129 | [
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0.3325007,
0.03437988,
0.1665428,
0.2233966,
0.33... |
[Changes in ultrastructural synaptoarchitectonics induced by endotoxin]. | The authors studied the ultrastructure of synapses of the dog sensory-motor cortex in response to intravenous injection of typhoid endotoxin. The most pronounced shifts were noted in the dendrite neuron apparatus. Activation in the cortical structures was connected with an increase in the number of functioning synapses... | 719,158 | [
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0.2011741,
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Xeroderma pigmentosum: heterogeneous syndrome and model for UV carcinogenesis. | Xeroderma pigmentosum (XP) is a rare inherited, heterogeneous syndrome with pigment anomalies, sun sensitivity, multiple cutaneous neoplasms and abnormal self protecting systems (SPS). The transmittence is autosomal-recessive. 50 percent of XP patients gets melanoma and 15 percent have neurological abnormalities. Clini... | 719,183 | [
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... |
Febrile convulsions--what do parents do? | To find out about the medical and parental management of children having their first febrile convulsion a hospital-based questionnaire study was carried out in which parents were asked what they did at the time. Fifty-four out of 89 parents brought their child directly to hospital while the remainder attempted to conta... | 719,385 | [
-0.1599865,
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... |
Total colonic aganglionosis. | This study is based on 17 neonates suffering from total colonic aganglionosis. The male:female ratio was 2:3 and there was a significant familial occurrence. The ages on admission varied between 1 and 90 days. The clinical presentation was extremely variable. Early diagnosis depends on clinical awareness of the conditi... | 719,562 | [
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0... |
Ultrastructural studies on neuroblastoma: evaluation of cytodifferentiation and correlation of morphology and biochemical and survival data. | Fifteen cases of neuroblastoma, ganglioneuroblastoma and ganglioneuroma were studied by electron microscopy. Ultrastructural features of cytodifferentiation, including numbers of dense core neurosecretory granules (NSG) and neuritic processes, were used to evaluate variation within the neuroblastoma group to determine ... | 719,615 | [
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0.1298406,
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... |
Partial "feedback control" of beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in primary hepatocellular carcinomas. | The activity of beta-hydroxy-beta-methylglutaryl coenzyme A reductase, the rate-controlling enzyme of cholesterol synthesis, was studied in normal livers and in 64 primary hepatocellular carcinomas from rats fed a basal diet or a diet containing either 2% cholestyramine or 5% cholesterol. The average enzyme activity in... | 719,632 | [
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0.1474689,
0.1582592,
0.1267454,
0.1452014,
0.33800... |
Elimination of hypoxic protection by 5-thio-D-glucose in multicell spheroids. | The effect of 5-thio-D-glucose on oxic and hypoxic V79-171 Chinese hamster cells was studied in vitro with single cells and multicell spheroids. At concentrations that were not toxic to oxic cells, this compound killed hypoxic cells with a D0 of 1 hr with a 5 mM concentration and more rapidly at 10 mM beginning 2 hr af... | 719,634 | [
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0... |
Intercellular glycosaminoglycans in normal and neoplastic tissues. | Intercellular glycosaminoglycans have been isolated from normal and neoplastic mammalian tissues. They have been characterized by cellulose acetate electrophoresis and by chemical and enzymatic degradation. The electrophoretic pattern of the intercellular glycosaminoglycans is tissue specific. Furthermore, the electrop... | 719,648 | [
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... |
Coronary vascular resistance and myocardial oxygen consumption dynamics in response to catecholamine infusion. | These experiments were performed in order to ascertain whether activation of coronary vascular adrenergic receptors could change the time course of the coronary vasodilatation accompanying increases in myocardial metabolic activity. The left common coronary arteries of dog hearts were perfused in situ with blood at con... | 719,651 | [
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0.02481094,
... |
Determinants of coronary sinus noradrenaline in patients with ischaemic heart disease: coronary sinus catecholamine concentration in relation to arterial catecholamine concentration, pulmonary artery oxygen saturation and left ventricular end-diastolic pressure. | Arterial and coronary sinus noradrenaline (NA) and adrenaline (A) concentrations, cardiac output, pulmonary artery oxygen saturation (PAO2), coronary sinus oxygen saturation, left ventricular end-diastolic pressure (LVEDP), and arterial pressure were examined in 21 patients with ischaemic heart disease at rest and duri... | 719,654 | [
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High resolution radioautographic study of newly formed protein in striated muscle with emphasis on red and white fibres. | The elaboration and distribution of newly formed proteins in the striated muscle of 21-day-old mice were investigated by quantitative radioautography at intervals between 2 and 240 min after intravenous injection of tritiated leucine. In radioautographs, the localization and the relative label concentration were compar... | 719,720 | [
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Temperature dependent ionic structure of phospholipid monolayers. | Radiotracer studies of calcium adsorption to dipalmitoylphosphatidyl-alkanolamine monolayers measured at various temperatures showed that the binding constant of calcium increased with temperature up to around 30 degrees C but the decreased on exceeding this critical temperature. The temperature dependent ionic structu... | 719,818 | [
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Improved liquid chromatographic determination of placental estriol in urine. | Placental estriol in urine can be determined, after enzymatic hydrolysis, by liquid chromatography. A single-step extraction technique results in rapid processing with minimal sample manipulation. Analytical recovery of estriol added to urine was 96 to 106%. Day-to-day precision (CV), established by 10 replicate analys... | 719,859 | [
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Interrelationship between vitamins E and A: a clinical study. | Plasma vitamin A and vitamin E levels were determined in 45 children. Seven normal children and 7 children with vitamin A deficiency were given daily supplements of 100 mg vitamin E for two weeks. Seven others received a placebo and served as controls. The mean levels of plasma vitamin E and A were 694 microgram/dl and... | 719,892 | [
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Preliminary studies with the sensitive cytochemical assay for parathyroid hormone. | A modification of the cytochemical assay for parathyroid hormone (PTH) is described which permits the measurement of as little as 0.1 fg ml-1. Using this assay circulating concentrations in normal humans range between 1 and 30 pg ml-1 using a bovine PTH standard. Elevated values are found in hyperparathyroidism with re... | 719,908 | [
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0.3024845,
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-... |
The relation between plasma androstenedione and oestrone levels in untreated and corticosteroid-treated post-menopausal women. | Plasma oestrone (E1) and androstenedione (A) were measured in 96 untreated and 18 corticosteroid-treated post-menopausal women. Levels of both hormones were consistently lower in the steroid-treated cases, presumably due to suppression of ACTH secretion. There was a clear relationship between A and E1 levels in both gr... | 719,911 | [
-0.0511648,
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... |
Induction of a stable hapten-specific immunosuppression by a hapten conjugated to poly(N-vinylpyrrolidone) (PVP). | The ability of a hapten coupled to a clinically permissive synthetic polymer (NIP-PVP) to induce suppression was investigated. NIP coupled to the low molecular weight non-immunogenic form of poly(N-vinylpyrrolidone) (PVP) was found to be capable of inducing a hapten-specific longlasting suppression of both primary and ... | 719,951 | [
-0.1811161,
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0.218137,
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Interactions between methaqualone and ethanol in rats and mice during acute and chronic states. | 1. The effects of acute and chronic treatment of methaqualone on ethanol preference, the rate of disappearance of ethanol and on toxicity were studied in mice and rats. 2. Acute treatment with methaqualone showed a dose-dependent suppression in the voluntary intake of ethanol in C57Bl/6J mice in rats. No significant ch... | 719,965 | [
-0.4744162,
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0.2354529,
... |
Free choline concentration and cephalin-N-methyltransferase activity in the maternal and foetal liver and placenta of pregnant rats. | 1. The concentration of free choline and cephalin-N-methyltransferase activity of the maternal and foetal liver and placenta of rats in late pregnancy were determined. 2. The choline concentration of the liver fell from a mean of 130 nmol/g in adult non-pregnant rats to 38 nmol/g in late pregnancy. 3. The choline conce... | 719,963 | [
0.09636249,
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0.1462753,
0.05736383,
0.151216,
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-0.00... |
Bone scintigraphy of osteoid osteoma: a clinical review. | Osteoid osteoma is a painful osteoblastic process. The pre-operative diagnosis is usually made by roentgenogram. Four surgically confirmed cases are examined where the preoperative diagnosis was clarified by bone scintigraphy. The clinical indications, the diseases process, the literature are reviewed. | 719,978 | [
-0.2023599,
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0.4103197,
0.1092851,
-0.02337... |
Analysis of wall motion abnormalities of the heart and great vessels by computer generated cine-radionuclide-equilibrium study. | Cardiac wall motion was evaluated in 54 patients by ECG-gated blood pool scintigraphy (GBPS) and computer assisted cine-radionuclide-equilibrium study (CRES). The cine format in CRES enhances the subtle aspects of great vessel and cardiac chamber motion and volume abnormalities. An off-line system using a general purpo... | 719,979 | [
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0.1550215,
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Computerized axial tomography in family members of patients with tuberous sclerosis. | The diagnosis of unsuspected TS has been reached with the aid of computerized axial tomography. Most cases are sporadic, but incomplete forms of the disease may be difficult to detect. We have, therefore, studied nine immediate family members of four cases with TS. The results were negative in all of them, confirming t... | 719,986 | [
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... |
What makes adolescent girls flee from their homes? An analysis of 50 such girls studied at Boston Juvenile Court. | Fifty girls who were arrested in Boston on a charge of running away and their parents were studied via psychiatric interviews, rating schedules and psychotherapeutic data. There was an absence of psychosis and mental retardation in this group. A diversity of factors leading to running away episodes were elicited. Sexua... | 719,987 | [
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0.0213413,
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... |
The effect of vibration on blood flow in skeletal muscle in the rabbit. | 1. The blood flow in rabbit gastrocnemius, as measured by photoelectric drop-counter, increased when the muscle was vibrated at frequencies of 22--62 Hz. 2. Blood flow increased rapidly within 1--2 s of the start of vibration, and lasted for the whole time vibration was applied. 3. The increase in blood flow was negati... | 720,000 | [
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0.09622332,
0.07376659,
0.02074573,
-0.10453... |
Phospholipid analysis in testis-epididymis complex after alpha-chlorohydrin administration. | alpha-Chlorohydrin, 6.5 mg/kg body weight for 14 days, did not alter total phospholipids, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, phosphatidyl inositol and sphingomyelin in rat testis and caput and corpus epididymis. However, marked decrease in total phospholipids, phosphatidyl choline, ph... | 720,057 | [
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0.1597135,
0.1498136,
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... |
No increase of the fibrinolytic activity of the human endometrium by progesterone-releasing IUD (ProgestasertR). | An increase in menstrual blood loss is one of the most common side effects of plastic IUDs and, though less often, also of copper IUDs. This has been explained by the observation that IUD enhances the fibrinolytic activity of the endometrium. A progesterone-releasing IUD (ProgestasertR) does not increase menstrual ble... | 720,058 | [
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0.3375235,
0.3812059,
0.3121701,
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... |
Circadian rhythms of electrolyte excretion in hypertensive patients and healthy subjects. | Analysis of data of 10 practically healthy subjects and 43 patients with hypertensive disease has indicated that there are circadian rhythms of urine volume and excretion of calcium, potassium, sodium, magnesium and phosphorus in healthy subjects. In the earlier stages of hypertensive disease significant rhythms of sod... | 720,173 | [
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0.0323494,
... |
Interrelationships among zinc, copper, lead, and cadmium in food, feces, and organs of humans. | Concentrations of zinc, copper, lead, and cadmium were determined in 20 samples of food collected over a period of 20 days, 221 samples of feces collected over a period of 5 days from 19 males, 17 females, and 11 children and 85 samples each of renal cortex and liver from autopsied human cadavers in order to investigat... | 720,297 | [
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0.08158336,
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0.1987268,
0.09704888,
0.5616183,
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... |
Metabolic interactions between metals and metalloids. | The experimental evidence obtained with laboratory animals which shows that the toxicities of lead, cadmium, and mercury can be increased by deficiencies of certain essential nutrients such as calcium, iron, zinc, and selenium is briefly reviewed. An idealized theoretical model which indicates the possible influence of... | 720,305 | [
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0.2331815,
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0.1367389,
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0.03550596,
0.3503737,
0.04871... |
Non-histone proteins in mononucleosomes and subnucleosomes. | Nucleosomes and subnucleosomes separated either by sucrose gradient ultracentrifugation or by polyacrylamide gel electrophoresis contain proteins incorporating [3H]tryptophan, i.e. non-histone proteins. The fractions of mononucleosomes MN3 and MN2 are enriched in these proteins as compared to the MN1 fraction. Two-dime... | 720,344 | [
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0.1110852,
0.2099599,
0.3714901,
-0.05199274,
-0.14209... |
Modern concepts of ventricular tachycardia. The value of electrocardiological investigations and delayed potentials in ventricular tachycardia of ischemic and nonischemic etiology (31 operated cases). | Concepts on ventricular tachycardia (VT) have markedly changed in the last 10 yr, with the help of sophisticated electrophysiological methods of study. The importance of the reentry phenomenon in the mechanism of the arrhythmias has been pointed out by stimulation procedures. Epicardial mapping allowed the localization... | 720,373 | [
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0.3048052,
0.1034962,
-0.0635485,
... |
Inhibition of synaptosomal uptake of norepinephrine and dopamine by conformationally restricted sympathomimetic amines. | The conformationally restricted cis and trans isomer of substituted cyclobutanes were examined for their ability to inhibit 3H-norepinephrine and 3H-dopamine accumulation by synaptosomes prepared from the cortex and corpus striatum, respectively. The drugs were more effective in preventing the accumulation of 3H-norepi... | 720,387 | [
-0.1292546,
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0.2906585,
0.009828187,
0.1431579,
0.292904,
0.0871579,
-0.01162061,
... |
Immune prophylaxis of experimental cancer by corynebacterium parvum. | Fractionated administration of C.p. i.v. in mice at risk from sarcomas after injection of 0.2 mg MCA leads to a significant prolongation of the period of latency under certain circumstances. Experimental groups which have received the immune stimulator for 6 weeks immediately after the cancerogenic factor show the best... | 720,440 | [
-0.2799363,
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0.0719561,
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0.7224096,
0.4707986,
0.2219449,
0.0788799,
... |
Ultrastructural relations of macrophages to Schwann cells. An experimental study on regenerating peripheral nerves. | The correlations between macrophages and Schwann cells are studied on transsectional sciatic nerves from rats using the electron microscope. As early as 1 day after operation typical macrophages can be found within the endoneurial space of the proximal stump. On the other hand, 1 and 3 days as well as 4 weeks after ope... | 720,441 | [
0.012202,
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0.152009,
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0.1219976,
0.03666088,
0.1164823,
0.2583533,
-0.... |
Estrogens as disposing factors in experimental liver injury. | The activity of hexobarbital metabolising enzymes of the liver is decreased as a consequence of both acute and chronical carbon tetrachloride damage. Simultaneous administration of estrogens was followed by more severe morphological and functional impairment although estrogens are not burdening the healthy liver. The b... | 720,449 | [
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0.03469836,
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0.2521153,
-0.02654224,
0.2832359,
-0.1997337,
0.4182116,
-0.1966... |
In vitro studies on lysosomes radiosensitivity in different gaseous atmospheres. | Radiosensitivity of lysosomes was investigated in vitro in different gaseous atmospheres. Results show a higher sensitivity when X-irradiation was performed in nitrous oxide. Possible reasons for this observation are considered. | 720,467 | [
0.09459516,
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0.2831963,
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0.... |
Determination of infarct size in rats with 86rubidium. | A quick method is presented which allows the determination of infarct sizes within hearts of experimental animals like rats. The method is based on the drop of 86Rb uptake in infarcted hearts, and has been compared with infarct sizes determined morphometrically. The standard deviation of this method is low (6.5%) becau... | 720,476 | [
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0.1252229,
0.02766808,
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0.29841,
0.2964277,
0.2112732,
0.1661646,
0.... |
Effect of the administration of (d-Ala) 2methionine-enkephalin on the serotonin metabolism in rat brain. | The effect of cerebroventricular injection of [D-Alanine] methionine-enkephalin (DALA), a synthetic analog of met-enkephalin, on the serotonergic system of rat brain has been studied. This opioid peptide caused an increase in 5HT turnover which was particularly evident in the limbic forebrain. This effect was completel... | 720,481 | [
0.08590735,
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0.05909946,
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0.08956378,
0.4079853,
0.1976953,
0.1780763,
0.2131969,
-0.0660104... |
Effect of pretreatment with prednisolone on the phagocytic activity of mouse peritoneal macrophages in vitro. | The phagocytic activity on in vitro cultured mouse peritoneal macrophages derived from animals treated with 6-alpha-methyl-prednisolone was examined. The statistical evaluation of results showed an increase of phagocytic activity of macrophages derived from treated animals in comparison with controls. | 720,487 | [
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0.1189624,
-0.08803751,
0.5658512,
0.07141301,
0.08965668,
0.1599233,
... |
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