title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Influence of mouse age and erythrocyte age on glutathione metabolism. | In order to determine whether the biological age of a mouse influences erythrocyte metabolism and erythrocyte aging in vivo, blood samples were collected from male C57/BL6J mice of different biological ages ranging from mature (10 months) to "very old" (37 months). In the very old mouse, compared with the mature mouse,... | 728,088 | [
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New reaction sequences for the non-oxidative pentose phosphate pathway. | 1. Reactions leading to the formation of 14C-labelled volatile compounds and compounds volatile under acid conditions were investigated in a system actively synthesizing hexose 6-phosphates from [U-14C]ribose 5-phosphate by reactions catalysed by enzymes prepared from acetone-dried powder of rat liver; no reactions inv... | 728,110 | [
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A sub-population of rat liver membrane-bound ribosomes that are detached in vitro by carcinogens and centrifugation. | The chemical-carcinogen-induced detachment of ribosomes from rat liver endoplasmic reticulum was studied in vitro. Incubation of postmitochondrial supernatant with 0.2 mM-diethylnitrosamine or N-2-acetylaminofluorene removed approx. 16% of membrane-bound ribosomes, measured as differences in RNA/protein values of membr... | 728,116 | [
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Blood lipids in Italy. Regional differences. | Serum cholesterol and triglyceride levels have been evaluated in samples from fasting males aged 20--59 in Northern (Brisighella), Central (Rome) and Southern (Pozzuoli) Italy. Regularly performed quality controls between laboratories assured comparability of data. A statisitically significant difference of mean serum ... | 728,233 | [
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[Moyamoya phenomenon and Moyamoya diseases (author's transl)]. | An unverified disease called "Moyamoya Disease" or "Spontaneous occlusion of the circle of Willis" has been recently reported as a disease entity by some Japanese researchers. Since the first report of this disease by Shimizu and the author in 1955, many cases have been reported not only in Japan but in many countries ... | 728,273 | [
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Adrenocortical suppression by synthetic corticosteroid drugs: a comparative study of prednisolone and betamethasone. | 1 Single-dose studies were conducted to investigate the relative potency of prednisolone and betamethasone in suppressing adrenocortical function. 2 Betamethasone produced more profound suppression of plasma cortisol than an equivalent anti-inflammatory dose of prednisolone. | 728,282 | [
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Effect of surgery under general anaesthesia on antipyrine clearance. | 1 The effect of surgery under general anaesthesia on drug metabolism was investigated in man. The activity of hepatic drug-metabolizing enzymes was evaluated by measurement of antipyrine clearance, before surgery and 3 days after surgery, in eighteen patients. 2 In those patients in whom the operation lasted 2 h or les... | 728,319 | [
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Repopulation of gamma-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors. | Cellular repopulation in Lewis carcinoma irradiated with 60Co gamma-rays was examined by performing sequential cell-survival estimations using an in vitro soft-agar-colony assay. Following local irradiation (15--35 Gy) two distinct types of colony were seen: compact colonies with tightly packed cells and diffuse coloni... | 728,347 | [
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Haem biosynthesis in rheumatoid disease. | The activities in blood of six enzymes of the haem biosynthetic pathway have been determined in 12 patients with rheumatoid disease, six of whom were anaemic. The porphyrin and porphyrin-precursor intermediary products of haem biosynthesis were also determined in blood, urine and faeces. No significant differences were... | 728,373 | [
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Quantitative abnormality of an Aalpha chain molecular weight form in the fibrinogen of cirrhotic patients. | The molecular weight heterogeneity of fibrinogen from the whole plasma of 12 normal and seven cirrhotic individuals was examined by means of a novel two-dimensional sodium dodecyl suphate (SDS) gel electrophoretic technique. Fibrinogen was first separated from other plasma proteins on a large pore gel, cut out of the g... | 728,374 | [
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Proposed structure for coenzyme F420 from Methanobacterium. | The low-potential electron carrier, coenzyme F420, was purified from Methanobacterium strain M.o.H. A yield of 160 mg/kg of wet-packed cells was obtained. Results of analysis of hydrolytic fragments and periodate oxidation products of the coenzyme, by infrared, UV-visible, 1H and 13CNMR spectrometry, mass spectrometry,... | 728,375 | [
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Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein. | Synthetic procedures have been developed for the preparation of peptides of arginine chloromethyl ketone and applied in the preparation of affinity labels which correspond to the -Pro-Phe-Arg- C terminus of bradykinin, a physiological cleavage site of kallikrein in kininogen. Two such reagents, Ala-Phe-ArgCH2C1 and Pro... | 728,386 | [
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Thermodynamics of the isothermal interaction of human immunoglobulin G with guanidinium chloride. | A thermodynamic study of the isothermal interaction of human immunoglobulin G with guanidinium chloride, a strong denaturant, has been performed. Free energies of interaction were calculated using preferential binding data obtained by measuring densities at constant chemical potential and constant composition, respecti... | 728,451 | [
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Three classes of sulfhydryl group in bovine alpha-crystallin according to reactivity to various reagents. | alpha-Crystallin from calf eye lens is found to have 30 sulfhydryl groups per 800 000 daltons by modification with 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) and 4,4'-dithiopyridine in 6 M urea. These -SH groups can be divided into three different classes in native alpha-crystallin from their reactivity with DTNB, 4,4... | 728,454 | [
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Binding of thrombin to human platelet plasma membranes. | Binding of 125I-labeled thrombin to isolated human platelet plasma membranes was studied. Two classes of sites, one with high and one with low affinity for thrombin, were demonstrated. The apparent dissociation constants for the high and low affinity sites were 3.2 and 600 nM, respectively, similar to values obtained w... | 728,459 | [
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Alphatic 3,4-epoxyalcohols. Metabolism by epoxide hydrase and mutagenic activity. | Rabbit hepatic microsomal epoxide hydrase catalyzes the rapid hydrolysis of 1,2-epoxy-4-heptanol to 1,2,4-heptanetriol. Both diastereomers of the substrate are hydrolyzed, and both product diastereomers are formed. Similarly both cis- and trans-3,4-epoxy-1-hexanol are hydrolyzed, albeit more slowly, to give 1,3,4-hexan... | 728,469 | [
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Role of spermidine in casein gene expression in the rabbit. | Spermidine concentration in rabbit mammary gland was estimated during pregnancy, lactation and after the induction of milk synthesis by prolactin and glucocorticoids in vivo and in vitro. It was observed that mammogenesis and lactogenesis during preganancy and the initiation of milk secretion at parturition are accompa... | 728,479 | [
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Performance of a model for a local neuron population. | A model of a local neuron population is considered that contains three subsets of neurons, one main excitatory subset, an auxiliary excitatory subset and an inhibitory subset. They are connected in one positive and one negative feedback loop, each containing linear dynamic and nonlinear static elements. The network als... | 728,488 | [
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On the correlation model: performance of a movement detecting neural element in the fly visual system. | The applicability of the basic principles of the correlation model to the description of the activity of a movement detecting neuron in the third optic ganglion of the fly's visual system has been investigated. This wide field neuron is supposed to sum the outputs of a large number of correlators (i.e. multiplying unit... | 728,496 | [
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Theoretical and experimental studies on viscoelastic properties of erythrocyte membrane. | The deformation of a portion of erythrocyte during aspirational entry into a micropipette has been analyzed on the basis of a constant area deformation of an infinite plane membrane into a cylindrical tube. Consideration of the equilibrium of the membrane at the tip of the pipette has generated the relation between the... | 728,524 | [
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Effect of tetramethylammonium ions on conformational changes of DNA in the premelting temperature range. | The reversible conformational change of DNAs and polydeoxyribonucleotides occurring before melting was followed by circular dichroism. deltatheta/deltaT, the rate of change of ellipticity theta with temperature, was used mainly as a measure of this premelting phenomenon. If sodium ions were replaced by tetramethylammon... | 728,539 | [
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Stacking interaction of nucleobases: NMR investigations. III. Molecular aspects of the solvent dependence. | The stacking interaction between nucleic acid bases has been investigated by the determination of the self-association of 6-methylpurine in various mixtures of water and nonaqueous solvents in order to elucidate the solvent effect. The parameters of stacking association as well as of local solvent-solute interactions h... | 728,544 | [
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[Changes in the content of eosinophils, corticosterone and catecholamines during liver regeneration following resection]. | Experiments on albino rats demonstrated changes in the-blood eosinophil level, as well as in the content of catecholamines and corticosterone in the plasma, the adrenal glands, and the heart following partial hepatectomy. Phasic character of the hypophysis-adrenal system responses to resection and the processes of the ... | 728,601 | [
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[Effect of protracted infusions of polyglucin during the resuscitation period on metabolic and morphologic characteristics of the brain]. | Polyglucine infusions (10 ml/kg) during the first 10 days of postresuscitation period after 4-hour hypovolemic hypotension promotes normalization of general RNA content, quick mobile protein fractions, corresponding prealbumins, albumins, postalbumins, ceruloplasmin, transferrin, and alpha-globulins. Macromolecular pro... | 728,603 | [
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[Role of the liver in the development of dyshormonal diseases of the mammary glands in rats]. | Intermittent administration of CCl4 combined with permanent illumination resulted in a decrease of the frequency of mastopathy and of the mammary gland tumours in immature female rats and prolonged the period of their appearance. It is suggested that during regression of cirrhotic lesions the liver can lose its capacit... | 728,615 | [
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[Role of carbohydrate-protein complexes in the organization of the microstructure of fibrous connective tissue]. | Samples of the tendons and fascia subjected to the action of amylolytic and proteolytic enzymes (protorysin, trypsin) were examined by scanning electron microscopy. Degradation of the carbohydrate-protein complexes proved to bring about disappearance of the characteristic morphological signs of the collagen fibers. It ... | 728,621 | [
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Evaluation of non-stimulated nitroblue-tetrazolium test in patients with malignant lymphomas. | The NBT-test was performed in 54 patients with Hodgkin and non-Hodgkin lymphoma showing no bacterial infection exept for one case. 18 patients presented, at onset of the disease, a number of neutrophilic NBT-reducing granulocytes at pathological levels (greater than 12%). In order to evaluate the influence of cytostati... | 728,624 | [
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Congenital chromosome anomalies. | The introduction of chromosome banding techniques has led to the detection of a greatly increased number of congenital chromosome anomalies, especially those involving duplication and/or deficiency of short segments of chromosomes. Of most widespread use are the general banding techniques: Q-, G- and R-banding. Special... | 728,674 | [
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0.05355223,
-0.1588854... |
A rating scale for mania: reliability, validity and sensitivity. | An eleven item clinician-administered Mania Rating Scale (MRS) is introduced, and its reliability, validity and sensitivity are examined. There was a high correlation between the scores of two independent clinicians on both the total score (0.93) and the individual item scores (0.66 to 0.92). The MRS score correlated h... | 728,692 | [
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Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes. | A simple test was devised to identify people susceptible to chlorpropamide-alcohol flushing (CPAF). Subjects were given a placebo tablet, followed by sherry 12 and 36 hours later. They then received a chlorpropamide tablet and sherry again after 12 and 36 hours. This single-dose challenge test was given to non-insulin-... | 728,707 | [
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Precordial exercise mapping: improved diagnosis of coronary artery disease. | Surface mapping of the exercise electrocardiogram (ECG) provides a measure of the precordial area, severity, and time course of ST-segment changes occurring after exercise. Sixteen-lead isopotential surface maps were recorded before and after exercise in 109 patients with probable angina who subsequently underwent coro... | 728,738 | [
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0.04765... |
Receptive field development in the dorsal lateral geniculate nucleus in rabbits subjected to monocular eyelid suture. | Receptive field properties of cells in the dorsal lateral geniculate nucleus (LGNd) were examined in 3 groups of rabbits, each subjected to monocular visual deprivation by lid suture at differing age periods. Monocular deprivation occurring from 6--8 to 20--25 days of age affected the normal development of LGNd recepti... | 728,802 | [
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A chemical study on the development of the human forebrain and cerebellum during the brain 'growth spurt' period. II. Phosphoglyceride fatty acids. | The changes of the fatty acid composition of ethanolamine phosphoglycerides (EPG) and choline phosphoglycerides (CPG) that are associated with the maturation of the human forebrain and cerebellum have been studied. The increase in the n-3 fatty acids and the 22:4(n-6)/22:5(n-6) index in the forebrain during the second ... | 728,806 | [
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Variability of the pulmonary vascular response to hypoxia and relation to gas exchange in dogs. | Anaesthetized and mechanically ventilated dogs were subjected to five minutes of alveolar hypoxia with Fio2 ranging from 0.08 to 0.20 while pulmonary artery pressure (Ppa), pulmonary wedge pressure (Pwp) and cardiac output (Q) were measured. Hypoxia increased Ppa in all dogs whereas Pwp and Q did not change significant... | 728,823 | [
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The growth of Mycobacterium convolutum on solid n-alkane substrates: effect on cellular lipid composition. | Growth rates and cell yields of Mycobacterium convolutum strain R22 grown on a wide range of both odd- and even-numbered carbon solid n-alkanes decreased as the substrate carbon number increased. Cellular lipid was 2.5 times higher following growth on the hydrocarbon substrates. The amount of polar lipid was found to b... | 728,850 | [
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Association of Kaposi's sarcoma and prior immunosuppressive therapy: a 5-year material of Kaposi's sarcoma in Norway. | A retrospective study of 53 cases with a histological diagnosis of Kaposi's sarcoma (KS) reported to The Cancer Registry of Norway during a five year period is presented. Four cases were excluded from the material because further information contradicted the diagnosis of KS. Of the remaining 49 cases, information of tr... | 728,865 | [
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Polyps of the large intestine in Northern Norway. | In unselected autopsies on 171 males and 109 females over 20 years of age in Tromsø, Northern Norway, adenomas of the colon and rectum were present in 40% of the males and 33% of the females. The frequency of adenomas increased with age in both sexes. Hyperplastic polyps were found in 20% of all cases with no variation... | 728,878 | [
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Malignant transformation of cryopreserved early passage syrian golden hamster cells by 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide. | 2-(2-Furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) induced the malignant transformation of secondary cultures of Syrian golden hamster embryo cells prepared from cryopreserved primary cells. Transformed cells grew in semi-solid agar medium and formed sarcomas when inoculated subcutaneously into non-immunosuppressed suck... | 728,882 | [
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Immunomodulating effects of BM 12.531 in animals and tolerance in man. | BM 12.531, a 2-cyansubstituted aziridine, has interesting therapeutic and immunomodulating effects. Antitumor effects in Meth A sarcoma in mice and an increase in resistance to Candida albicans infection in mice have been found. It was demonstrated that BM 12.531 can modulate the immune system in animals (DTH lymphocyt... | 728,913 | [
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Fine structure of the pineal organ in the troglobytic fish, Typhlichthyes subterraneous (Pisces: Amblyopsidae). | The pineal organ of the blind, cave-dwelling fish, Typhlichythyes subterraneous, was examined with both light and electron microscopes. Like the eyes, the pineal in this troglobytic species was found to be regressed. Two cell types, photoreceptor and supportive cells, were described in the pineal epithelium. Although g... | 728,980 | [
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Differential expression of the gene for the large subunit of ribulose bisphosphate carboxylase in maize leaf cell types. | Mesophyll cells and bundle sheath cells, the dimorphic photosynthetic cell types in the C4 plant Zea mays, differ in protein composition. In particular, the large subunit of the chloroplast enzyme ribulose-1,5-bisphosphate carbocylase (EC 4.1.1.39) is found entirely or almost exclusively in bundle sheath cells. The DNA... | 728,987 | [
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Coincidence of the promoter and capped 5' terminus of RNA from the adenovirus 2 major late transcription unit. | During the late stage of adenovirus 2 infection, RNA chains are initiated at a site near coordinate 16 (Evans et al., 1977) and transcribed approximately 30,000 nucleotides to the far end of the genome at coordinate 100. Late mRNAs processed from these transcripts contain a common spliced tripartite leader (Berget, Moo... | 729,003 | [
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Regression analysis in interlaboratory surveys: a case study with cholesterol and triglycerides. | 1. A new interlaboratory survey design, that uses regression analysis to compare results from each laboratory with target values, was tested using cholesterol and triglyceride analyses. The fifty New Zealand laboratories involved showed considerable interlaboratory variation (CV = 8% to 27% for cholesterol, 13% to 113%... | 729,161 | [
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A high pressure liquid chromatographic determination of p-chlorophenoxyisobutyric acid and its comparison to a GLC and an ultra violet spectrophotometric method. | A rapid and reliable method for the determination of clofibric acid in serum using high pressure liquid chromatography has been elaborated and compared to a GLC and UV spectophotometric procedure. The limit of detection of the method is 0.3 micrograms/ml. | 729,163 | [
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Quantitative determination of thiazides in urine by a sensitive colorimetric method. | Chloriothiazide and hydrochlorothiazide may be determined in urine by the Bratton-Marshall reaction after extracting with ethyl acetate and treating the extract with Florisil. Such treatment reduces the background color of the urine sample and eliminates interferences. The modified procedure is thus sensitive enough to... | 729,164 | [
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The dermatoglyphic pattern of the trisomy 10p syndrome. | Dermatoglyphic findings are reported for six members of a family in which two patients have partial trisomy for the short arm of chromosome 10(p13 leads to pter) and there are two unaffected carriers of the balanced translocation t(5;10)(p15;p13). The patterns are compared with those of nine other published cases of tr... | 729,197 | [
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Left atrial receptor inhibition of cardiac efferent vagal activity in the dog. | 1. The tachycardia produced by atrial receptor stimulation has been reported to be 'solely' due to an increased sympathetic activity, but not inhibitable by propranolol. We examined the effect of left atrial balloon inflation in chloralose-anaesthetized dogs on heart rate with and without propranolol (1.0 mg/kg) and on... | 729,206 | [
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Toxic psychosis induced by phenothiazine administration in patients with chronic renal failure. | Adverse reactions to phenothiazines have not been commonly recognized in patients with chronic renal failure. We wish to report a characteristic acute psychosis as a complication of phenothiazine use in such individuals. Four patients with chronic renal failure requiring hemodialysis were given doses of chlorpromazine ... | 729,214 | [
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A clinical follow-up of the pes anserinus transplantation for chronic anteromedial rotatory instability of the knee. | Twenty-seven patients with chronic anteromedial rotatory instability were treated by pes anserinus transplant with an 85% satisfactory result. Muscle rehabilitation is absolutely essential for a good result. Delay of surgery by prolonged conservative management may contribute to the development of degenerative changes ... | 729,233 | [
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... |
Knee flexion test and sciatica. | Knee flexion of the leg when a patient with sciatica bends to reach the floor is objective evidence of lumbar spinal nerve root compression. Contralateral sciatic scoliotic list usually accompanies the finding, which should be known as a positive knee flexion test for sciatic spinal nerve root compression. | 729,249 | [
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Undiagnosed bleeding states and medical treatment. | Relatively little attention has been placed in mild hemophilia in the orthopedic literature even though there are probably an equal number of patients with mild as compared to classic manifestations. Mild hemophilia and similar related conditions frequently are undiagnosed and may represent major problems and if associ... | 729,252 | [
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Current concepts in synovial fluid analysis. | The systematic examination of synovial fluid confirms the noninflammatory nature of degenerative joint disease, is diagnostic of gout, pseudogout, and septic arthritis, and will usually allow the identification of rheumatoid arthritis, systemic lupus erythematosus and Reiter's syndrome. | 729,254 | [
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Methylprednisolone in posttraumatic pulmonary insufficiency. | The effect of methylprednisolone, 30 mg/kg on the musculoskeletal trauma model in dogs were compared with the previously reported untreated models. The atelectasis, inflammation, and alveolar membrane thickening were ameliorated. There was a decrease in the coagulopathy of trauma as well as increased cardiac output, pu... | 729,264 | [
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0.0756... |
Continuous transphyseal traction: experimental observations. | Observations of canine tibias lengthened by continuous transphyseal distraction (without osteotomy) reveals an acute fracture through the metaphyseal zone of primary trabeculae and rapid osseous healing. Long-term follow-up demonstrates normal subsequent growth. | 729,275 | [
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Tuberculosis joint infection. | A retrospective study of tuberculosis infection of joints over a 10 year period has identified 21 documented cases. The patients were, for the most part, of rural, middle-class background and usually in the fifth to seventh decade. Diagnosis was commonly missed with the exception of spinal lesions. Presentation was usu... | 729,294 | [
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0.05084... |
Granulomatous hepatitis: spectrum of scintigraphic manifestations. | Four cases of granulomatous hepatitis are presented. Hepatocellular disease in general and the clinical, histological and scintigraphic manifestations of granulomatous hepatitis are discussed. | 729,311 | [
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Myelofibrosis presenting as hypermetabolic bone disease by radionuclide imaging in a patient with asplenia. | In a patient with myelocytic anemia, hepatomegaly, and metastases suggested by radiographic evidence of sclerosis throughout the pelvis and spine, a liver-spleen scan revealed mild hepatomegaly and an absent splenic image. A bone scan demonstrated diffusely increased activity in all bones, especially in the joint regio... | 729,316 | [
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Improving the evaluation of human services by separating the delivery of service from service. | The delivery of services has been receiving increased attention in recent years. Judicial action combined with budgetary constraints have focused on the need for greater scrutiny and accountability in service delivery. Although much is being written in this regard, there are at present few attempts to provide a concept... | 729,348 | [
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Occurrence of ovulation in women receiving the injectable contraceptive norethisterone oenanthate. | Ovarian function was studied in ten women receiving a single intramuscular injection of 200 mg norethisterone oenanthate. Two of the ten women appeared to ovulate within 60 days of injection and a further four within 90 days. Follicular activity probably not followed by ovulation occurred in five subjects within 60 day... | 729,379 | [
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Risk factors and survival prognosis in men younger than 40 years and men older than 60 years with myocardial infarction. (Retrospective clinico-epidemiological study). | In a clinico-epidemiological retrospective study there were examined 300 men younger than 40 years and 300 men older than 60 years with clinically or histologically diagnosed myocardial infarction (by WHO criteria). The study has confirmed that clinically unequivocal myocardial infarction in men younger than 40 years i... | 729,383 | [
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Cigarette smoking and prevalence of microangiopathy in juvenile-onset insulin-dependent diabetes mellitus. | In order to evaluate a possible relation between cigarette smoking and prevalence of diabetic microangiopathy, a series of 180 consecutive patients suffering from insulin-dependent juvenile-onset diabetes mellitus with different durations of disease (60 patients each with diabetes for 10 to 19 years, 20 to 29 years, an... | 729,438 | [
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Changes in aerobic fitness and body fat during army recruit training. | Aerobic fitness and related indices were evaluated in 254 soldiers at the beginning and near the end of initial army recruit training. Aerobic fitness in terms of maximal aerobic power was preidcted from the Astrand-Ryhming submaximal heart rate bicycle test. Estimated VO2 max increased by 8%, 42.0--45.3 ml/kg . min. ... | 729,569 | [
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Structure and replication of echovirus type 12. 2. Viral polypeptides synthesized in the infected cell. | A technique has been devised which allows us to label predominantly echovirus-12-specific proteins: upon infection in the presence of D-(--)-2-(alpha-hydroxybenzyl)benzimidazole plus actinomycin D the shut-off of host-cell protein synthesis takes place as in infected, untreated cells, but the bulk of viral protein synt... | 729,594 | [
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The comparative bioavailability of Lanoxin tablets and Lanoxicaps with and without sorbitol. | (1) The mean cumulative urinary digoxin excretion over 8 days was compared in 8 healthy volunteers after single doses of digoxin administered as 3 Lanoxin tablets of 0.25 mg, 3 digoxin tablets of 0.2 mg, 12 Lanoxicaps without sorbitol of 0.05 mg, 6 Lanoxicaps without sorbitol of 0.1 mg digoxin, 3 Lanoxicaps without sor... | 729,628 | [
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The retinotopic distribution of visual callosal projections in the suprasylvian visual areas compared to the classical visual areas (17, 18, 19) in the cat. | The distribution of the interhemispheric projection from area 17 and 18 was studied using the anterograde degeneration technique. Besides the classical visual areas (17, 18, 19), area 21 and several visual areas in the middle suprasylvian sulcus also received visual callosal input. In the four terminal areas of the mid... | 729,661 | [
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Multiple spatial-frequency tuning of electrical responses from human visual cortex. | Human occipital potentials evoked by stimulation with a counterphase flickering grating were recorded by a digital narrowband filter technique. The data showed a surprising degree of narrow tuning to particular spatial frequencies in addition to the expected narrow temporal frequency tuning. At each temporal frequency,... | 729,663 | [
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The validity of the estimates of the half-saturation concentration and maximum velocity for the efflux of glucose from human erythrocytes in infinite-cis conditions. | It is shown that, if the asymmetrical model for glucose transport is correct, the published estimates of this half-saturation concentration must be low. As a result, the model is even less able than before to satisfy the tests of its validity. | 729,713 | [
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Inactivation of superoxide dismutase by several thiocarbamic acid derivatives. | 4 thiocarbamic acid derivatives inhibited superoxide dismutase (SOD) activity in vitro. Dimethyldithiocarbamate also inhibited tissue SOD in mice in vivo. These data extend previously published results on the inhibitory action of diethyldithiocarbamate on SOD activity. | 729,714 | [
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Effects of disuse and nerve stump length on the development of fibrillation in denervated soleus muscle. | Both in normal (control) and in cordotomized (disused) rats, the soleus muscle was denervated either by cutting the sciatic nerve near the trochanter (proximal denervation) or by cutting the soleus nerve near the insertion into the muscle (distal denervation). In the control muscles, the development of fibrillation was... | 729,718 | [
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The peritoneal leukocytes of the germ-free mouse. | The cytology of the lavage-recoverable peritoneal cell population of germ-free mice is similar to that of conventional controls. The microbial status has no effect on the total counts, differential counts or 3H-thymidine labelling index of peritoneal leukocytes. | 729,743 | [
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Spermatocyte selection during meiosis following mitomycin C treatment in mice. | In mice treated with mitomycin C, elimination of spermatocytes is observed during meiotic division, whereby an increase in number of the eliminated cells is closely related to an increase in the frequency of spermatocytes with chromosome aberrations at M-I. | 729,744 | [
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A rapid and simple method for the isolation of pure eosinophilic leukocytes from horse blood. | An improved and short method is described for the isolation of intact eosinophilic leukocytes from horse blood with high yield (1--1.5 g/20 l). Viability and purity of the preparations were verified by light and electron microscopy and by the trypan blue exclusion test. Isolated eosinophils were 98--100% pure, intact a... | 729,750 | [
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Pregnancy success following abdominal myomectomy for infertility. | There were 46 patients with primary infertility (34 patients) or secondary infertility (12 patients) with no other detectable cause except myomas. After myomectomy, 38% of the patients with primary infertility had full-term pregnancies and 50% of those with secondary infertility. Preoperative distortion of the endometr... | 729,825 | [
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In vitro reversal of indomethacin-blocked ovulation by prostaglandin F2alpha. | An in vitro perfused ovary preparation was used to study the role of prostaglandin F2alpha (PGF2alpha) in follicle rupture. The administration of PGF2alpha alone has been shown to restore indomethacin-blocked ovulation in rabbits and monkeys. In the model used, ovulation consistently occurred when human chorionic gonad... | 729,832 | [
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[Microiontophoretic study of the effect of acetylcholine and noradrenaline on the monosynaptic reflex activity of the spinal cord]. | In anesthetized and spinal cats the influence of microionophoretic local injections of acetylcholine and noradrenaline into different layers of grey substance of lumbar segments of the spinal cord were studied with aid of monosynaptic EPSPs of motoneurons. Injections of ACH and NA in the surface layers of the grey subs... | 729,840 | [
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Ornithine decarboxylase activity in rat liver during phalloidin poisoning. | Rat liver ornithine decarboxylase activity was measured during phalloidin poisoning of 17 day-old rats, adult rats, and adult rats protected against phalloidin toxicity by pretreatment with somatotropin. The results show: 1. In adult rats, after a short period of activation, ornithine decarboxylase activity decreases t... | 729,885 | [
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Scanning electron microscopic observations on cells grown in vitro. IV. HeLa cells do not have an upperside-underside polarity. | Small glass particles are added to HeLa monolayer cell cultures. Landing on top of a flattened cell fingerlike protrusions are surrounding the particles. Later on leading lamellae are formed on the upperside of the cell and the glass becomes more and more surrounded until it appears to be "incorporated" completely. The... | 729,887 | [
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Fingerprint body myopathy: a report of twins. | Ultramicroscopic changes of subsarcolemmal fingerprints in the muscle of children with infantile hypotonia and weakness may represent a specific congenital entity. Four children have been reported so far. The two children reported in the present paper are the first full siblings to be described and, in addition, are id... | 729,932 | [
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Adenocarcinoma of the stomach in association with Menetrier's disease. | Menetrier's disease is an uncommon lesion which may have malignant potential. This report documents a case of gastric malignancy arising in a patient with long-standing Menetrier's disease and emphasizes that close follow-up of patients with this condition is necessary because of the possible development of gastric mal... | 729,986 | [
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Kaposi's sarcoma of the intestinal tract: roentgen manifestations. | Five cases of generalized Kaposi's sarcoma are reported with roentgen evidence of involvement of the intestinal tract. In three instances, there was extensive involvement of the small bowel with multiple intramural nodules. The fourth patient demonstrated multiple polypoid lesions of the colon, and in the fifth a const... | 729,992 | [
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Obstructing giant pseudopolyps in granulomatous colitis. | Two cases of giant pseudopolyps occurring in Crohn's disease of the colon are presented. In both there was obstruction to retrograde flow of barium, and in one the patient presented with acute obstruction. | 729,994 | [
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Regulation of mouse major urinary protein production by the Mup-A gene. | A method was developed to quantitate the daily excretion of the three major urinary proteins (mups) to test which parameters of the mup phenotype are controlled by the the Mup-a gene. Electrophoretic separation of the mup proteins, followed by staining and spectrophotometric scanning was used to characterize the phenot... | 730,052 | [
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Venous prostaglandin-like activity in diarrhoeal states. | Prostaglandin E2-like activity was determined in peripheral venous blood of control subjects and in patients with acute gastroenteritis and active ulcerative colitis, using a bioassay method. No significant diurnal variations of prostaglandin levels were detected in the control group, while significantly raised venous ... | 730,074 | [
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0.03112316,
... |
Is hypergastrinaemia associated with rheumatoid arthritis? | In an attempt to confirm the reported high incidence of raised serum gastrin levels in patients with rheumatoid arthritis (RA), gastrin concentrations were estimated in 54 patients. Only three patients (6%) had basal hypergastrinaemia. The heptadecapeptide (G17) and total carboxyl-terminal immunoreactive gastrin respon... | 730,075 | [
-0.2364932,
-0.2169704,
-0.4559998,
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0.0696777,
0.1569509,
0.3032505,
0.1144586,
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0.1811527,
0.1818516,
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0.1790859,
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0.3207906,
0.0384591,
0.004928056,
0.3824487,
0.1512935,
0.07201307,
-... |
Plasma ratio of valine, leucine and isoleucine to phenylalanine and tyrosine in liver disease. | The molar ratio valine + leucine + isoleucine/phenylalanine + tyrosine was determined in the plasma of patients with liver disease of varying aetiology and severity and in an age and sex matched control group. In the control group of 58 subjects the mean ratio was 3.3 +/- 0.5 (ISD). The mean ratio was significantly low... | 730,076 | [
-0.06612971,
0.08809829,
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0.141874,
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0.02235835,
0.03564157,
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0.149853,
0.02292621,
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0.2741447,
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0.1751924,
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0.3312417,
-0.07059442,
0.2842278,
0.2543305,
... |
[Experimental studies on extracorporeal liver perfusion.--Development and evaluation of an improved circuit (author's transl)]. | Clinical application of the extracorporeal liver perfusion has been rather limited mainly because of cumbersome procedure, not infrequent circulatory insufficiency due to large priming volume, and bleeding tendency due to hepatic insufficiency itself and heparinization, which are inherent with most of the currently ava... | 730,106 | [
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0.02493376,
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0.08358161,
0.2356999,
-0.1487989,
-0.18471... |
Pure Sertoli cell tumour of the ovary: report of a case with ultrastructural observations. | A case of pure Sertoli cell tumour of the ovary is described. Unusual features were its great size, lack of clinical hormonal activity and the presence of granulomas in its interstitium. Mitochondria with tubular christae are described for the first time in such a tumour. These, together with lipid droplets and plentif... | 730,124 | [
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0.3206792,
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... |
The nephron in transport of sodium, amino acids, and glucose. | The ability of the kidney to maintain overall control of sodium and fluid balance appears greater than the sum of its parts, yet microperfusion and dissection studies that have assigned particular transport processes to individual segments of the nephron are helping to clarify a number of clinical states. Among those t... | 730,132 | [
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0.328306,
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0.1420812,
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0.2940124,
-0.1667611,
-0.033... |
Malignant histiocytosis of the intestine. Its relationship to malabsorption and ulcerative jejunitis. | The clinical and histopathologic features in seven patients with intestinal lymphoma are reported. Three of these presented with ulcerative jejunitis and four with overt lymphomas. A short history of abdominal pain with weight loss followed by intestinal obstruction, hemorrhage, or perforation characterized all the pat... | 730,148 | [
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0.2135922,
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0.3887645,
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0.1789636,
0.3848651,
-0.07266419,
... |
Surface and transmission ultrastructural characteristics of desquamative interstitial pneumonitis. | A prospective study of eight patients with desquamative interstitial pneumonitis was performed, correlating surface ultrastructure as elucidated by scanning electron microscopy, transmission electron microscopy, viral cultures of fresh sterile lung tissue obtained at thoracotomy, and immunomicroscopy. The hypothesis th... | 730,151 | [
0.1347564,
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0.1012735,
0.1952035,
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0.1106811,
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0.1957852,
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0.3710889,
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0.2264746,
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0.06186457,
0.1813731,
0.1114874,
0.0336979,
0.2648013,
0.01797696,
-0.38... |
Genetic components in susceptibility to nasopharyngeal carcinoma. | A series of blood samples from more than 200 histologically confirmed Chinese patients with NPC in Singapore were typed for 25 genetically controlled red-cell enzyme and five serum protein systems. A comparable number of patients suspected of having NPC but histologically negative and a series of healthy unrelated Chin... | 730,195 | [
0.07222961,
-0.4321778,
0.08490332,
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0.3351558,
0.09657231,
0.05830467,
0.2451771,
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0.08857116,
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0.1514478,
0.05562746,
0.05116461,
0.3155599,
-0.14136... |
Cytogenetic observations on the malignant epithelial cells and infiltrating lymphocytes of nasopharyngeal carcinoma. | Because of the presence of a No 14 chromosome marker abnormality in EB virus-carrying cells from African Burkitt's lymphoma (BL) but not from other origins, and the association of EB virus with nasopharyngeal carcinoma (NPC) as well as BL, both the malignant epithelial cells and the non-malignant lymphoid cells of NPC ... | 730,196 | [
-0.3882144,
0.0704565,
0.009815877,
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0.1356053,
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0.3542956,
0.418306,
0.1452276,
0.09618099,
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0.07855871,
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-0.04970106,
-0.03290386,
-0.01547415,
0.1938265,
0.1157771,
-0.05122629,... |
Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. | Nineteen human breast carcinoma cell lines have been established as continuous cultures during the past 6 years in our laboratory. This preliminary report is designed to list the lines by their designated code numbers (MDA-MB) and present a brief summary of their morphological, cytogenetic and biochemical characteristi... | 730,202 | [
-0.3072777,
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-0.0180133,
-0.4922087,
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0.2914602,
0.1990321,
0.1888742,
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0.2524238,
0.3094015,
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0.06015696,
0.1766293,
0.1419111,
0.2783993,
0.04325722,
-0.1478116,
... |
[The formulation of semi-defined culture media to overcome antibiotic antagonism (author's transl)]. | Semi-defined susceptibility media are a compromise between undefined and totally defined media. Antibiotic antagonism can still occur in semi-defined media. The undefined nutrients antagonizing sulphonamide/trimethroprim and the defined additives antagonizing other antibiotics. Methods used to overcome these problems a... | 730,217 | [
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0.07709394,
0.1926306,
0.1780969,
0.02256978,
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0.2791019,
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0.02887259,
0.2455238,
0.1239428,
0.3980684,
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-0.7488036,
-0.03200776,
-0.5555672,
0.2010859,
0.2104601,
-0.03995874,
0.05577671,
... |
[The microtiter system for sensitivity testing (author's transl)]. | In conclusion, the microtiter system has several advantages over conventional broth dilution methods. It is more rapid to set up, economical in its use of media and materials, and many more strains can conveniently be tested on the same occasion and under the same conditions, giving better comparability. Microtitration... | 730,220 | [
-0.000003381285,
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0.07011674,
0.01585402,
0.03081601,
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0.2595656,
0.1473716,
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0.1495981,
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0.2462024,
0.250746,
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-0.5632356,
0.2600045,
-0.2177388,
0.441146,
0.621132,
-0.2471479,
0.2276864,
... |
Experience with the AO method in the treatment of 142 cases of fresh fracture of the tibial shaft treated in the UK. | A prospective study was carried out on 142 fresh fractures of the tibial shaft treated by internal fixation according to the AO principles, 99 fractures being closed and 43 open. A total of 140 cases was reviewed at 1 year and 125 cases at 2 years following injury, at which times a functional assessment score was award... | 730,329 | [
-0.0155277,
0.1556034,
-0.0452435,
0.07300666,
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0.08973674,
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-0.08913901,
0.03940956,
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0.08386783,
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-0.300655,
0.02572394,
0.1396491,
0.03895015,
0.1266382,
0.1714869,
-0.07006424,
-0.098641... |
The treatment of non-union and pseudarthrosis of the long bones with thick nails. | This paper is based on Küntscher's method of operative treatment of the long bones(Küntscher, 1962) and is a review of 197 cases of non-union and pseudarthrosis of long bones fixed internally with thick metal nails after preliminary reaming of the medullary canal. New reamers and a new nail have been designed and the r... | 730,342 | [
-0.08074633,
0.2406933,
0.04817337,
0.05195501,
-0.07611555,
-0.4210903,
0.09014139,
0.1086591,
0.06841604,
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0.05816863,
0.195946,
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0.3063401,
0.007469942,
-0.08748037,
-0.08982035,
0.02787619,
-0.01581085,
-0.2... |
Purification of lipoteichoic acids by using phosphatidyl choline vesicles. | Lipoteichoic acid (LTA) is a component of nearly all gram-positive membranes and recently has been found to be excreted into growth media by certain lactic acid bacteria. Cell-free extracts of LTA are usually contaminated with proteins, polysaccharides, and nucleic acids, thus causing problems to investigators studying... | 730,344 | [
0.0140896,
0.003722272,
0.04413554,
0.02853066,
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0.2792598,
0.3070031,
0.06786238,
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0.2731683,
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-0.3218417,
0.007438641,
0.04523503,
-0.172686,
0.5946995,
0.4393543,
-0.206602... |
Influence of cadmium on the phagocytic and microbicidal activity of murine peritoneal macrophages, pulmonary alveolar macrophages, and polymorphonuclear neutrophils. | A significant depression in the phagocytic capacity of elicited peritoneal macrophages, pulmonary alveolar macrophages, and elicited peritoneal polymorphonucleated neutrophils was manifested when the cells were incubated in medium containing cadmium chloride. With the exception of the neutrophils, a similar influence w... | 730,360 | [
0.05230314,
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0.07259845,
0.01007408,
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-0.03067281,
0.3057044,
0.2967767,
-0.166862,
0.2909505,
0.0389378... |
New cellular and extracellular amphipathic antigen from Actinomyces viscosus NY1. | A new type of amphipathic antigen was isolated from culture supernatants and cells of Actinomyces viscosus NY1 and partially characterized as a fatty acid-substituted heteropolysaccharide. Similar components have been detected serologically in other strains of Actinomyces. | 730,376 | [
-0.1794437,
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0.137405,
-0.1132428,
0.5033856,
0.5106488,
-0.2188986,
... |
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