title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Melanotic neuroectodermal tumor of infancy with highly differentiated neural component. Light and electron microscopic study. | A pigmented tumor was removed from the maxillar alveolar process of a 5-month-old boy. It was examined by light and electron microscopy and a diagnosis of melanotic neuroectodermal tumor was made. In addition to connective tissue, three main cell types were identified: undifferentiated (stem) cells, melanocytes, and ne... | 735,759 | [
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Optic disc cupping and prematurity. Large cups as a possible low birth weight sequel. | In a previous ophthalmic study of ex-prematures around the age of 10 years it was accidentally found that cupping of the optic disc was significantly more pronounced in children of a low birth weight (less than 2000 g) than in full-term controls (Fledelius 1976). This was true for cup size (cup/disc diameter ratio) as ... | 735,767 | [
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Some observations on visual evoked responses (VER) to dichoptic stimulation. | The possibility that the interocular depression of VER seen with dioptic stimulation, might reflect alternate suppression or binocular rivalry, unnoticed by the test subjects, was investigated in VER experiments using dichoptic stimulation with patterns of dissimilar form. Red and blue grating and checker board pattern... | 735,772 | [
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Spondyloysis. The role of the posterior elements in resisting the intervertebral compressive force. | Compressive tests were carried out on cadaveric lumbar intervertebral joints, before and after the neural arch was fractured. The results show that although the neural arch can play some part in resisting the intervertebral compressive force, there is no bony contact between the downward projecting tips of the inferior... | 735,787 | [
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Cone arthrodesis of the first metatarsophalangeal joint. | An operation for arthrodesis of the first metatarsophalangeal joint described previously has been performed on 85 toes in 68 patients over a 20-year period. The notes and X-rays have been reviewed to determine the incidence of bony fusion and to find out whether the operative position was maintained until union occurre... | 735,790 | [
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Congenital dilatation of intrahepatic bile ducts associated with hepatic fibrosis and medullary sponge kidney--reconstruction and microdissection study. | An autopsy case of a four-year-old female with congenital dilatation of intrahepatic bile ducts with bilateral medullary sponge kidney is presented. The liver and kidney were investigated by reconstruction with serial sections and the kidney was also studied by microdissection. In this case the dilatations of collectin... | 735,821 | [
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Fusiform aneurysm of basilar artery associated with bilateral choroidal cysts. | A case of large fusiform aneurysm of the basilar artery and bilateral choroidal cysts in the lateral ventricles is reported. The pathogenesis of the choroidal cysts is briefly discussed. | 735,822 | [
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Left ventricle of the heart on conventional lateral chest films. | Segments of the left ventricular circumference were visible within the radiologic image of the heart on conventional full size lateral chest films of 122 patients; in 75 the findings were confirmed by cardioangiography. The presence of the epicardial fat layer and the locally varying thickness of the heart in the direc... | 735,848 | [
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Properties and latencies of potentials evoked in postganglionic sympathetic nerves by electrical stimulation of aortic, sinus and hypoglossal nerves in cats. | The properties and latencies of potentials evoked in cardiac (CN) and renal (RN) sympathetic nerves by electrical stimulation of the sinus, aortic and hypoglossal nerves were studied in cats. Electrical stimulation of the sinus nerve evoked only excitatory responses in the sympathetic nerves. Electrical stimulation of ... | 735,883 | [
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Ataxia and disorders of purine metabolism: defects in hypoxanthine guanine phosphoribosyl transferase and clinical ataxia. | A relationship between disordered metabolism of purines and the central nervous system has been established by the Lesch-Nyhan syndrome. In this disorder a virtually complete defect in the activity of HGPRT is associated with a syndrome of severe mental retardation, choreoathetoid cerebral palsy, and bizarre, self-muti... | 735,927 | [
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Orbital auscultation. | Orbital auscultation is recommended as a screening technique in patients with subjective bruit or tinnitus, persistent conjunctivitis, exophthalmos, headache, seizure disorder and other neurologic and psychiatric symptoms. It can reveal carotid-cavernous fistula, cerebral arteriovenous malformation, an intracranial mas... | 735,987 | [
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The use of triamcinolone acetonide in the treatment of severe intrinsic bronchial asthma. | A group of 145 patients with severe intrinsic bronchial asthma symptoms was treated with repeated intramuscular injections of triamcinolone acetonide (Kenalog) during an average period of two years. Kenalog was administered mainly to persons with persistent attacks of asthmatic dyspnea and frequent recurrent infections... | 735,981 | [
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A community mental health innovation in mass media preventive education: the alternatives project. | An innovative mental health primary and secondary prevention program employing mass media was conducted in the Louisville metropolitan area. For 60 weeks during public service announcement time slots, 21 educational mental health and mental retardation messages were aired on local major radio and television stations. T... | 736,008 | [
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The Aymara of Western Bolivia. IV. Gene frequencies for eight blood groups and 19 protein and erythrocyte enzyme systems. | A total of 315 individuals, mainly of Aymara origin, from western Bolivia were examined for genetic variation at eight red cell antigen and 19 serum protein and red cell enzyme loci. The gene frequencies for polymorphic loci and the discovery of several rare variants are discussed in terms of previous work among the Ay... | 736,042 | [
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Antepartum fetal heart rate testing: the nonstress test. | Antepartum assessment of fetal well being relies heavily on the observation of RHR. Fetal stress testing was introduced in the early 1970's in an attempt to define the fetus at risk. The stress factor most widely used has been uterine contractions, which isolate the fetus from its oxygen supply, and in the compromised ... | 736,062 | [
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Acute macular neuroretinopathy. | A 17-year-old boy had minor visual impairment, paracentral scotomata, and parafoveal retinal lesions following a presumed viral infection. Contact lens biomicroscopy demonstrated the retinal defects to be located at the level of the deep sensory retina. Fluorescein angiography revealed subtle areas of hypofluorescence ... | 736,073 | [
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Bare sclera closure in retinal detachment surgery. | Our modification of the limbal peritomy technique in retinal detachment surgery involved recession of the confunctiva 3 mm posterior to the corneoscleral limbus as the conjunctiva was closed. This recession offered some advantages over the standard nonrecessed method: fewer sutures were required; postoperative ophthalm... | 736,074 | [
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Use of dilute drug solutions for routine cycloplegia and mydriasis. | Clinic patients and students were given several regular drops of commercial 10% phenylephrine HCl, and 1.0% cyclopentolate HCl or 1.0% tropicamide HCl. The drops were given three times at five-minute intervals. Mydriasis and cycloplegia were determined and compared with the results obtained by using one of the followin... | 736,080 | [
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Trauma to the lacrimal system in children. | We repaired damage to the lacrimal drainage system in a series of 393 children who had lacrimal obstruction caused by congenital obstruction or facial injuries. Delayed surgery for traumatic obstruction of the nasolacrimal duct in children, including infants, was successful in all cases. | 736,082 | [
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Comparison of vision screening performed by optometrists and nurses. | The rates of patient referral by optometrists and nurses working independently and conjointly in vision screening of schoolchildren are compared. Very few studies in the literature have examined the difference in referral rate; this difference is important because of the shortage of qualified manpower to screen the lar... | 736,094 | [
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Biofeedback of accommodation to reduce functional myopia: a case report. | A 30-yr-old man received biofeedback training of his accommodation to reduce his functional myopia. There were seven training sessions for a total time of 34 min. Each training session consisted of a baseline-level recording period followed by a feedback period, a second baseline-level recording period, and then a seco... | 736,097 | [
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Bioconverter for upper extremity rehabilitation. | The bioconverter is a simple instrument which uses the output of the Basmajian-Emory myotrainer to activate electrical devices, such as radios, television, etc. It can be used to assist in training by providing an acceptable and/or pleasurable stimulus (such as a radio) as muscle activation improves. The myotrainer con... | 736,101 | [
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Methods of isoelectric focusing. | The method of isoelectric focusing has been avoided by many workers because of expense, technical difficulty, and problems of interpretation. Inexpensive, easy, and interpretable results are possible using equipment and reagents commonly available. Methods which allow these results are presented and explained. | 736,112 | [
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Disruptive effect of test meals on interdigestive motor complex in dogs. | The disruptive effect of food and food components on the migrating myoelectric complex (MMC) was studied in conscious dogs. Three types of test meals were fed, and the interval between feeding and the reappearance of the first phase III of the MMC was determined. When commercial dog food was used a linear relation was ... | 736,125 | [
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Cellular and paracellular calcium transport in rat ileum: effects of dietary calcium. | The mechanism of calcium transport and its modulation by dietary Ca restriction in rat ileum have been investigated employing an in vitro voltage-clamp technique. Ca fluxes directed from mucosa-to-serosa (J(Ca)ms) and serosa-to-mucosa (J(Ca)sm) exhibit components consistent with both cellular and paracellular pathways.... | 736,134 | [
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Effect of exogenous and endogenous angiotensin II in the isolated perfused rat kidney. | Rat kidneys were perfused with an artificial solution at constant pressure. The infusion of angiotensin II (AII) (1.5--6 ng min-1) reduced renal perfusate flow (RPF) from 36.6 +/- 2.4 to 19.3 +/- 1.4 ml min-1 (P less than 0.001) (n = 13); GFR rose from 0.48 +/- 0.06 to 0.63 +/- 0.04 ml min-1 (P less than 0.05), and fil... | 736,144 | [
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Transcellular and paracellular tracer chloride fluxes in Necturus proximal tubule. | Necturus proximal tubule lumen was filled with solutions of Na36Cl or [36Cl]tetramethylammonium ([36Cl]TMA) and the tracer disappearance was measured. With these tracers it was possible to differentiate between chloride fluxes across the cellular and the extracellular shunt pathways. Since it was previously shown that ... | 736,146 | [
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Acute cardiac ischemia and reperfusion: contractility, relaxation, and glycolysis. | The mechanical and metabolic effects of 3 min of complete global ischemia and 25 min of reperfusion were studied in the isolated rat heart. The decrease in contracile function was biphasic; a rapid 50% decline occurred in the first 10 s of ischemia, after which contractile function transiently stabilized and then fell ... | 736,151 | [
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0.08994326,
0.2115796,
0.1191991... |
Solitary (localized) pleural mesothelioma. A light- and electron-microscopic study. | Six solitary (localized) pleural mesotheliomas were studied by light and electron microscopy. All the lesions were benign and were composed mainly of fibrous tissue of variable cellularity with or without cystic spaces lined by round cells. The lining cells of the cysts and the adjoining round plump cells were interpre... | 736,211 | [
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0.161... |
Clinical experience with an alloplastic spermatocele. | During the last 4 years we succeeded in proving in experiments in rats and bulls that a cup-shaped silicone-dacron prosthesis may be used as Sperm-reservoir. Spermatozoa--aspirated from this reservoir and stored as pellets in liquid nitrogen over 6 weeks--induced pregnancies and normal births in 50 percent of inseminat... | 736,276 | [
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0.003994253,
... |
Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. | To determine the effects of hypothermia on the pharmacokinetics and pharmacodynamics of d-tubocurarine (dTc), serum, biliary, and urinary concentrations were determined and twitch tension monitored following intravenous administration of dTc, 0.7 mg/kg, at 39 (n = 5), 34 (n = 5), and 28 C (n = 6) in cats anesthetized w... | 736,287 | [
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Epididymal sperm reserve in Buffalo-bulls (Bubalus bubalis). | Epididymal sperm reserve was determined in 6 sexually mature fertile buffalo-bulls having normal process of spermatogenesis. The relative distribution of spermatozoa in the caput, corpus and cauda epididymidis averaged 5.42, 0.75 and 11.45 billion respectively. Total epididymal sperm reserve per bull averaged 36.2 bill... | 736,280 | [
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[Influence of the hematocrit on the formation of Heinz bodies within the red cells (author's transl)]. | The increased in vitro formation of Heinz bodies in erythrocytes exposed to oxidant agents (acetylphenylhydrazine) is an excellent screening test for the diagnosis of various congenital abnormalities of red blood cells (G-6-PD deficiency, unstable haemoglobins). This phenomenon is strongly dependent of the PCV of the t... | 736,319 | [
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Bone-remodeling rates of the Beagle: a comparison between different sites on the same rib. | The standardized colony-raised male Beagle is being used more frequently for research purposes. The rib of this dog is an ideal bone on which to measure haversian bone-remodeling activity. To date there has been little indication as to whether there has existed any natural statistically significant differences in bone-... | 736,329 | [
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Baylisascaris procyonis for testing anthelmintics against migratory ascarids. | Oral inoculation of mice with 340 embryonated eggs of the nematode, Baylisascaris procyonis, proved uniformly fatal as early as 13 days after inoculation and as late as 48 days. Mice given either 0.5% or 0.25% of pyrantel tartrate in dry feed were protected from cerebral migrations of the worm for 55 days. Treatment wi... | 736,349 | [
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Lactic acidosis presenting as acute respiratory failure. | Two patients with chronic obstructive pulmonary disease and chronic respiratory failure who developed acute lactic acidosis are described. The initial arterial blood gas values in both patients had the pattern of acute respiratory failure with no metabolic disturbance. It was the calculation of the "anion gap" that pro... | 736,361 | [
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A successful treatment for aphakic cystoid macular edema. | Twenty-eight consecutive cases of aphakic cystoid macular edema in 16 patients were treated with corticosteroid drops. Enough medication was used in each occurrence to achieve intraocular pressure elevation. This increases the hydrostatic pressure on the retina thereby decreasing retinal swelling pressure and reversing... | 736,409 | [
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Plasma 25-hydroxyvitamin D and alkaline phosphatase isoenzymes in hyperthyroidism. | Plasma 25-hydroxyvitamin D (25-OHD) values in 22 hyperthyroid patients did not differ significantly from those of controls matched for age, sex, and the time of year that plasma samples were taken. In the hyperthyroid group, plasma alkaline phosphatase was significantly higher than in controls, and an increase in bone ... | 736,491 | [
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Antibiotics in acute cholecystitis. | In 460 cholecystectomies performed for acute cholecystitis 215 (47%) positive gallbladder bile cultures were obtained. In 73% of emergency operations bacteria were recovered, in 48% of early operations (p less than 0.001) and in 29% of late operations (p less than 0.001). In vitro concentrations of 8-16 mcg/ml of ampic... | 736,504 | [
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0.016... |
The response of human platelets to hypotonic stress: direct measurement of volume change. | Human platelets stored at 22 degrees C were subjected to standard hypotonic stress at intervals up to five days after collection. Changes in light absorbance were recorded during the reaction, and size distribution was measured directly using a Coulter Model ZBI Counter and Channelyzer. Recovery following osmotic stres... | 736,508 | [
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Platelet and granulocyte pheresis. | The need for sophisticated component therapy has resulted in improved techniques for obtaining concentrates of platelets and granulocytes. The use of single donors as a source for these products is advisable to avoid multiple sensitizations. A method for obtaining large quantities of platelets has been established rath... | 736,509 | [
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0.076... |
Serological studies of a host range mutant of a lactic streptococcal bacteriophage. | A host range mutant was isolated from a bacteriophage that attacked Streptococcus cremoris 114. The mutant was able to adsorb and grow on S. cremoris 266, where the parent phage could not. The mutant phage was unable to adsorb to the original bacterial host, S. cremoris 114. The change in host range was accompanied by ... | 736,537 | [
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... |
Microbial succession and mineral leaching in an artificial coal spoil. | An artificial pyritic coal spoil was prepared and examined over a period of 1.5 years for changes in the population of various physiological varieties of bacteria and also for mineral leaching. Heterotrophic bacteria were the first to dominate the spoil, acquiring a population of 10(7) cells per g within 2 weeks. Bacte... | 736,542 | [
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... |
Comparative follow-up study of conservative and surgical treatment of femoral shaft fractures in children. | The guiding principles of treatment of femoral shaft fractures in children are discussed. Up to the age of six years a Bryant or Weber bandage was used. In older children surgical treatment was preferred. The indications are outlined. Between 1959 and 1974 100 children with femoral shaft fractures were treated in the M... | 736,579 | [
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Allergic contact dermatitis to 1,4-bis(isopropylamino)anthraquinone. Caused by a felt-tip marker pen. | Adult allergic contact dermatitis to the black ink of a felt-tip marker pen occurred in two adult subjects. In both subjects the cutaneous reaction did not require photoactivation. Patch testing with the ingredients in the black ink demonstrated cutaneous sensitivity to the black dye. Further patch testing with the com... | 736,588 | [
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Increased blood lead levels in mentally retarded children in Greece. | In 60 children with mental retardation of unknown etiology, the whole blood lead, as well as the activity of the red cell delta-aminolevulinic acid dehydratase (delta-ALAD), was measured. Thirty normal children and 30 with mental retardation of known etiology were used as controls. The lead values were found significan... | 736,612 | [
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0.02... |
Mortality experience of arsenic-exposed workers. | The mortality experience of all pensioners from a copper smelter who were aged 65 or over between 1949 and 1973 has been studied. An index of arsenic exposure was developed for all operations in the plant for 1973. This was applied to all individuals studied so that a comparative measure could be made of each individua... | 736,617 | [
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0.05766697,
... |
Postmastectomy reconstruction. | Reconstructive surgery following mastectomy has had an increased acceptability with improved techniques and prostheses. Plastic reconstructive procedures following prophylactic mastectomy were performed in 104 patients and following mastectomy for cancer in 88 patients. Capsular contractions have not occurred with the ... | 736,655 | [
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0.1073... |
Muscle blood flow following thermal injury. | Peripheral circulation is markedly increased during the hyperdynamic-hypermetabolic phase of thermal injury and appears to be directed primarily to the burn wound. To determine whether any portion of this extra blood flow reaches another major peripheral vascular bed, blood flow in the tibialis anterior muscle of the l... | 736,656 | [
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0.0222390... |
The exsheathment and migration of Brugia pahangi microfilariae in mosquitoes of the Aedes scutellaris species complex. | Studies on the Aedes scutellaris complex of mosquitoes showed that refractory and susceptible species can be distinguished by reference to the proportion of Brugia pahangi microfilariae which reach the thorax within three hours of a feed. Migration ceased approximately 1 1/2 hours after feeding in refractory species, i... | 736,663 | [
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... |
Hyaluronidase release from guinea pig spermatozoa as affected by reproductive tract secretions and metabolic inhibitors. | Cauda epididymal sperm of mature guinea pigs were incubated (37 degrees, 5% CO2 in air). 10% of the total enzyme activity was released into the medium in 4 hr, 30% in 24 hr. Addition of lysolecithin resulted in rapid release of hyaluronidase. Vitamin C (0.54 mM), sodium fluoride (0.02 M), and cholesterol increased the ... | 736,670 | [
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... |
Pharmacological effects of a combination of butorphanol and acetaminophen. | Isobolographic analysis was used to study in mice the combined oral analgetic action of butorphanol, a new centrally acting analgetic, and acetaminophen, an antipyretic analgetic. Combinations of butorphanol-acetaminophen exhibited analgetic effects which were greater than were expected from just an additive analgetic ... | 736,686 | [
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0.1109002,
0.2295146,
... |
Pharmacological analysis of the effects of substituted benzamides on the isolated guinea-pig ileum. Study of metoclopramide, sulpiride, bromopride, tiapride and sultopride. | The effects of metoclopramide (Mcp), sulpiride (Sp) and some of their derivatives: bromopride (Br), tiapride (Ti) and sultopride (Stp) have been compared on the guinea-pig isolated ileum. 1. Br and Ti have, like Mcp, and indirect cholinergic stimulating effect on the intestinal smooth muscle. Sp and Stp are devoid of s... | 736,692 | [
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0.4769941,
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0.4028705,
0.133635... |
A modulating role of prostaglandins in responses of guinea-pig isolated ileum to various agonists. | Small doses of prostaglandin E2 (0.3, 0.6 and 0.9 ng/ml) and prostaglandin F2alpha (0.25, 0.5 and 0.75 ng/ml) significantly potentiated the responses of the guinea-pig isolated ileum to cholinergic substances, i.e. acetylcholine, methacholine, carbachol and pilocarpine. All substances were applied from the serosal surf... | 736,700 | [
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[Behavior of various blood constituents (glucose, fructose, insulin, lactate, pyruvate, free fatty acids, inorganic phosphate) and half-life of monosaccharides in the plasma after i.v. infusion of glucose, fructose, galactose and invert sugar solutions in ruminants. 1. Studies in calves and heifers]. | Studies into the half-life of monosaccharides as well as into the effects of intravenous infusion of sugar solutions (0.5 g/kg body weight of glucose, fructose, galactose, and invert sugar) on the concentration of various blood components were undertaken with six calves and five heads of young cattle. Half-life values ... | 736,715 | [
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[Behavior of various blood constituents (glucose, fructose, insulin, lactate, pyruvate, free fatty acids, inorganic phosphate) and the half-life of monosaccharides in plasma after i.v infusion of glucose, fructose, galactose and invert sugar solutions in ruminants. 3. Studies in sheep]. | Monosaccharide half-life as well as the effects of intravenous infusion of 0.5 g/kg body weight glucose, fructose, and invert sugar solutions on insulin levels in blood plasma as well as on pyruvate and lactate concentrations in the blood were measured in two adult sheep weighing 72 kg and 65 kg. The half-life values f... | 736,717 | [
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[Determination of enzyme activities in the synovial fluid of farm animals]. | Reported in this paper are methods for spectrophotometric determination of the activities of lactatedehydrogenase (LDH) and aspartate-aminotransferase (AspAT) and for colorimetric determination of the activity of N-acetyl-beta-glucosaminidase (NAG) in the synovial fluid of farm animals. Optimum conditions are suggested... | 736,724 | [
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Hemiplegic spasticity: neurophysiologic studies. | The excitability of segmental reflex pathways in normal subjects and in patients with hemiplegia has been examined by conditioning the monosynaptic H reflex with a 200 msec burst of vibration applied to the tendo Achilles. In 6 normal subjects, the burst of vibration produced a short-latency facilitation of soleus moto... | 736,764 | [
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Hemodynamic effects of dopamine in septic shock with and without acute renal failure. | Hemodynamic response to dopamine hydrochloride in septic shock with myocardial dysfunction was studied in ten patients with normal renal function (group 1) and in ten patients with acute renal failure (group 2). The control hemodynamic data were similar in the two groups. Dopamine in groups 1 and 2 induced significant ... | 736,773 | [
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Role of liver glutathione in 1,1-dichloroethylene metabolism and hepatotoxicity in intact rats and isolated perfused rat liver. | The liver glutathione content was measured after oral administration of 1,1-dichloroethylene (vinylidene chloride = VDC; dissolved in olive oil) and its significance for the metabolism and hepatotoxicity of VDC was investigated. After treatment with 1000 mg/kg VDC p.o., glutathione decreased to 33% of the control value... | 736,789 | [
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[Several important questions concerning the segmental structure of dog liver]. | Anatomical structure of the dog liver has been studied in 82 isolated preparations. Besides the external surface of the organ, the study has been carried on in preparations of intraorganic branches of the portal vein, hepatic veins. Roentgenography of the portal vein and the hepatic artery has been performed. According... | 736,805 | [
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[Cytomorphological classification of pretumorous lesions and squamous cell cancer of the cervix uteri]. | A cytomorphological classification of pretumour lesions and squamous cell carcinoma of the cervix based on the determination of the degree of atypical condition and differentiation of the epithelium is proposed. This classification is an attempt to synthesize the previous cytological classifications with histological c... | 736,820 | [
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Electron microscope study of basophilic cells in allergic nasal secretions. | In order to elucidate whether basophilic cells in nasal secretion belong to blood basophil or tissue mast cell, basophilic cells in the blood, nasal secretion, and nasal mucous membrane were electron microscopically observed in patients with house dust nasal allergy. The majority of basophilic cells in the nasal secret... | 736,829 | [
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Heroin addiction: what can the GP do? | This article is based on nine months as a casualty coordinator, and eighteen months of weekly GP sessions at a drug dependency unit--a limited experience which justifies no claim to expertise. However, I believe my former ignorance to be fairly typical, so that my comments may have value for GPs. Although the comments ... | 736,836 | [
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The necessity for information on medical manpower needs in Australia and its attainment. | Authorities of all descriptions have been shown to require reasonably accurate ongoing statistics on medical manpower so they can make satisfactory plans and arrangements for the future. It is submitted that this information is no less important for medical graduates in planning their own personal future careers. Metho... | 736,856 | [
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Duodenal ulcer. | Duodenal ulcer is a common disease which places heavy demands on health care costs. The aetiology is unknown, but its pathogenesis is related to acid secretion. The characteristic symptom is chronic epigastric pain which precedes meals, occurs one to three hours after food, and one to two hours after retiring. The pain... | 736,857 | [
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Heterosis in a wild strain of Drosophila polymorpha with a lethal closely linked to the major esterase locus. | A laboratory population derived from a single wild inseminated female has a lethal so closely linked to the major esterase locus that in 3 years of observations no crossover products have been detected. Linkage with a chromosome inversion was excluded by cytological analysis. The heterozygotes are superior to the homoz... | 736,887 | [
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Differential effects of non-ionic detergents on microsomal and sarcolemmal adenylate cyclase in cardiac muscle. | 1. About 4 and 23% of the homogenate adenylate cyclase activity was recovered in the microsomal and sarcolemmal fractions isolated from guinea-pig heart ventricles. 2. Cardiac microsomal adenylate cyclase activity [basal as well as p[NH]ppG (guanyl-5'-yl imidodiphosphate)- and NaF-stimulated] was increased over 2-fold ... | 736,892 | [
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Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain. | Three novel peptides derived from lipotropin, the C-Fragment (residues 61-91), C'-Fragment (61-87) and N-Fragment (1-38), were isolated from pig pituitary, and the C-Fragment was shown to be present in brain. The experimental procedures developed for their isolation are described. The formation of each of the fragments... | 736,896 | [
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Dissociation of fibronectin from gelatin-agarose by amino compounds. | Soluble fibronectin of human plasma was specifically dissociated at neutral pH from gelatin-agarose by several cationic amino compounds, notably the polyamines spermine, spermidine and putrescine, the basic amino acid arginine, and amino sugars. The neutral and acidic amino acids and the N-acetylated derivatives of ami... | 736,901 | [
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... |
Evaluation of PUVA, topical corticosteroids and the combination of both in the treatment of psoriasis. | A total of 90 patients with psoriasis were treated either by photochemotherapy (PUVA) or by topical steroids under occlusion (TOC). In a third group of patients a combination of both regimens was applied. All patients received approximately 15 treatments of either type. During therapy, biopsies were taken in all treatm... | 737,132 | [
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Mourning and the prevention of melancholia. | Freud suggested that a high level of ambivalence in the previous relationship between the bereaved and the deceased was likely to complicate the process of mourning, perhaps leading to melancholia. Within a study testing the effectiveness of preventive intervention, a subgroup of recently bereaved widows (n = 22) were ... | 737,142 | [
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Kinetics studies on the renal transport of probenecid in vitro. | 1. The kinetic parameters of renal transport of probenecid have been assessed by studying the uptake of the drug in rabbit kidney tubules incubated in an electrolyte medium under various conditions. 2. The added compounds inhibited the uptake of probenecid both by kidney cortical slices and separated renal tubule prepa... | 737,176 | [
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[Possible biochemical mechanism of the toxic effects of barbiturates]. | Administration of amytal or phenobarbital to rats results in inhibition of liver respiration determined by oxygen uptake in isolated tissue preparations. Increasing doses of phenobarbital cause an increase of inhibition of liver respiration. In vitro addition of vitamin K3 to liver preparations from rat treated by amyt... | 737,214 | [
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[Kinetics and thermodynamics of heat inactivation of L-threonine-L-serine dehydratase from human liver]. | It has been shown that heat inactivation of L-threonine- and L-serine dehydratase activities at 37; 45; 50 and 55 degrees C in human liver extracts (the liver was ectracted with buffer containing 1.10(-5) M of pyridoxal 5'-phosphate) in course of time is practically identical, and characterizes by the same of values of... | 737,218 | [
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[Peptidase activity of Coccidioides immitis]. | Glycyl-L-leucinehydrolase consisting of three molecular units was extracted from C. immitis solid cultural medium. During fractionation in polyacrylamide gel of the enzyme-containing extract a 50-fold purification of the enzyme isoform with molecular weight 12,800 is achieved. The enzyme is heat-stable, active in the n... | 737,221 | [
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[Changes in the specificity of DNA methylation in cattle blood lymphocytes under chronic lymphoid leukemia]. | Under conditions of chronic (spontaneous) lympholeucosis the amount of 5-methylcytosine in cattle blood lymphocyte DNA is decreased approximately by 30%. No other changes in the DNA (e. g. GC-content, Tm, amount of pyrimidine sequences differing in their lengths and composition) were observed. Thus, the decrease in the... | 737,223 | [
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[Creatine phosphate synthesis coupled to glycolytic reactions in heart cell cytosol]. | It is shown that a cytosolic fraction of proteins from rat heart, containing all glycolytic enzymes and creatine phosphokinase (CPK) in natural proportions, catalyses in the presence of creatine (Cr) the intensive creatine phosphate (CP) synthesis coupled to glycolytic depletion of glucose, fructose-1,6-diphosphate (FD... | 737,230 | [
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Aluminum levels in brain in Alzheimer's disease. | In both human Alzheimer's disease and aluminum encephalopathy of animals, changes are observed in neurofibrillary structures. We have found that brains from Alzheimer patients contain approximately 1.4 times the aluminum level found in a control series. Some possible methodological problems are discussed. We have propo... | 737,258 | [
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An immunologic comparison between bone marrow and spleen-derived pluripotent hemopoietic stem cells (CFU-S) of mouse : effect of rabbit anti-mouse brain serum. | We used rabbit anti-mouse brain serum (RAMBS), with known activity against pluripotent hemopoietic stem cells (CFU-S) of mice, to compare the proportions of CFU-S from bone marrow and spleen which express the brain-associated CFU-S antigen(s). Eighty percent of marrow and 77% of spleen-derived CFU-S were inactivated by... | 737,278 | [
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Obstructive jaundice and portal vein calcification. | Two patients with extrahepatic portal vein obstruction are described in whom calcification within the thrombus was identified during investigation for obstructive jaundice. Evidence from percutaneous cholangiography in one, and endoscopic cannulation of the common bile duct in the other, supported the view that the com... | 737,407 | [
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The influence of size and radiopharmaceutical concentration ratio on the detection of abnormalities in clinical radionuclide imaging. | The effect of the size of an abnormality on its detectability was measured. The cylindrical abnormalities studied, with diameters ranging from 3 mm to 4 cm, were superimposed on a uniform background. To avoid artefacts produced by the imaging devices, the images were simulated by computer. The method of constant stimul... | 737,412 | [
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A review of 158 gunshot wounds to the chest. | One hundred and fifty-eight gunshot wounds to the chest treated at the Royal Victoria Hospital, Belfast, between August 1969 and July 1976 are reviewed. The place of open operation in the treatment is discussed. | 737,419 | [
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-0.08886918,
-0.1465981,
-0.1726049,
-0.05999978,
0.1812524,
0.05292572,
-0.1483098,
0.2956333,
0.03890762,
0.054827... |
Injuries in Rugby Union football. | In a prospective study of 185 players attached to 10 British rugby clubs, 151 injuries were recorded among 98 of them (53%) during a single season. Forwards sustained significantly more injuries than backs. The standard of rugby, players' body weights, degree of fitness, and presence of joint hypermobility did not affe... | 737,483 | [
-0.1139501,
0.2641441,
-0.09925905,
0.06801132,
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0.1288593,
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0.02452687,
0.1769913,
0.09554169,
-0.3130705,
0.1682659,
0.1829397,
-0.0322173,
-... |
Management of non-specific urethritis in men. Evaluation of six treatment regimens and effect of other factors including alcohol and sexual intercourse. | A trial comparing the efficacy of three different tetracyclines, each in two different dosage regimens, in the treatment of non-specific urethritis is described. There was a significant association between the retreatment rate and sexual intercourse. Age, race, duration of symptoms, previous infection, and indulgence i... | 737,518 | [
-0.09722316,
0.2330184,
-0.2503399,
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0.07929221,
0.2814615,
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-0.1916565,
0.02307796,
-0.4103004,
-0.206881,
0.01848628,
0.1693987,
0.080271... |
Surface area of dental enamel, bone, and hydroxyapatite: chemisorption from solution. | The surface areas of three different samples of hydroxyapatite, samples of deproteinized bone, and samples of whole and deproteinized enamel were determined by adsorption of an adduct (the diglycidyl ether of bisphenol A with N-phe-nylglycine) from methylene chloride solution. In all cases, the surface areas of these s... | 737,559 | [
-0.05710416,
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0.2284787,
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0.3358264,
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0.1954513,
0.1660079,
-0.1013408,
0.3718987,
-0.1170156,
-0.1566185,
-0.... |
Correlation of lysozyme activity with proteoglycan biosynthesis in epiphyseal cartilage. | Pig epiphyseal cartilage (proximal ulna epiphysis) previously incubated into vitro in the presence of sodium [35S]sulfate or [3H]thymidine was either analyzed by autoradiography or separated into 9 morphologically defined consecutive layers and investigated for 35S-incorporation into the guanidinium chloride-extractabl... | 737,563 | [
0.07183861,
0.0341804,
0.1073936,
0.1863202,
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0.2688936,
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0.07802604,
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0.3527059,
0.6702672,
-0.06436367,
0.03481541,
... |
Tuberculous peritonitis in Manitoba. | Between Jan. 1, 1971 and June 30, 1976 the authors diagnosed tuberculous peritonitis in 17 patients. The basis for the diagnosis was a positive culture for Mycobacterium tuberculosis from the peritoneal fluid or nodules (nine patients) or the presence of caseating granulomas in biopsy specimens of the peritoneum (eight... | 737,593 | [
-0.146749,
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0.07019122,
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-0.0006443864,
-0.02149381,
0.01557332,
-0.1252834,
0.1128991,
-0.127... |
Squamous cell papilloma of esophagus. | Squamous cell papilloma of the esophagus is rare. Seven well-documented cases have been reported in the English literature. Three further cases are presented, in one of which symptoms were related to the tumour. Although there is no proof that this lesion is premalignant, coincident cancer must be excluded. In each of ... | 737,594 | [
-0.2805687,
-0.1840394,
-0.2573482,
-0.229021,
-0.04726122,
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0.214891,
0.2456117,
0.2634455,
0.1673384,
0.09189138,
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-0.1843137,
0.1017262,
0.03180684,
-0.007554138,
0.2332603,
0.09283749,
-0.08953309... |
Carcinomatous pseudothyroiditis: a problem in differential diagnosis. | A 51-year-old woman presented with a painful, rapidly enlarging thyroid gland. The serum concentrations of the thyroid hormones were initially at the upper limit of normal, and the uptake of radioactive iodine by the thyroid was completely depressed. Although subacute thyroiditis was suspected, a biopsy specimen from t... | 737,640 | [
-0.1462805,
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0.2328644,
0.00538221,
0.1716742,
0.1971534,
0.1924177,
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0.1060741,
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0.0651335,
0.1959687,
0.09966121,
-0.130287,
-0.02847016,
0.0382044,
-0.2463684,
0.... |
Changes in structure of ventral epidermis of Rana ridibunda during metamorphosis. | The organisation of the ventral epidermis organisation was followed throughout ontogenesis in Rana ridibunda. Epidermis of tadpoles with 2-3 limbs was organised into two layers: a stratum germinativum consisting of elongated columnar cells, and an outer stratum corneum consisting of two types of cuboid cells. Two types... | 737,704 | [
0.3576843,
0.1714901,
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0.002330012,
0.04323113,
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0.08240327,
0.01083345,
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0.0008477259,
0.02194441,
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-0.008390341,
0.2882619,
-0.01662379,
0.7292555,
0.4627409,
-0.151... |
Complete differentiation of adipocyte precursors. A culture system for studying the cellular nature of adipose tissue. | Evidence for the complete morphological maturation of precursor cells into adipocytes in vitro is presented. Cells were isolated from the stromal fraction of adipose tissue from adult humans and from rats and were grown in culture. Abdominal skin fibroblasts were used as controls. All cell strains were initially fusifo... | 737,724 | [
0.04318734,
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0.3870025,
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0.2846036,
0.1234009,
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0.01077613,
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0.2613517,
0.3124565,
0.1776451,
-0.3266177,
... |
Transmural myocardial infarction in the absence of coronary arterial luminal narrowing in a young man with single coronary arterial anomaly. | Reported is a case of single coronary arterial anomaly (SCAA) with its origin from the right sinus of Valsalva as demonstrated by selective coronary arteriography. No branches coursed between the great vessels. Electrocardiography and vectorcardiography were consistent with inferior wall myocardial infarction, although... | 737,733 | [
-0.2796353,
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0.1148797,
0.00643262,
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0.1947217,
0.05135798,
0.1705979,
0.1375768,
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0.02505655,
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-0.2897791,
0.1399476,
0.0944735,
-0.4001366,
0.108793,
0.01819421,
0.04090747,
... |
Inhibition of kidney tubule induction by charged polymers. | Charged polymers, known to alter cell surface characteristics, reversibly inhibit the intercellular communication required in kidney tubule induction. This effect seems to be a function of their charge density. It is suggested that this effect is due to the formation of a molecular barrier between the interacting cell ... | 737,739 | [
-0.01573029,
0.1150442,
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0.155225,
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0.08410063,
0.12309,
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0.08719417,
0.1652357,
0.1886709,
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0.04245648,
-0.2015254,
0.2059186,
0.382913,
0.1423053,
-0.1014552,
-0.00... |
[Association of left diaphragmatic hernia, lung agenesia and esophageal atresia (author's transl)]. | A literature study has been written about each failure concerning a very particular mishaping linking an agenesy of the left lung and of the left diaphragm to an esophagal atresia (type III). None similar case has been discovered in the literature. Concerning the diaphragmatic agenesies, the authors report several fami... | 737,826 | [
-0.110282,
-0.3048207,
0.06438252,
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0.03857097,
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0.1458933,
0.2585059,
0.1085649,
0.09933981,
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0.02789884,
0.04384052,
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0.2833856,
0.186844,
-0.2210004,
... |
A scheme for the evaluation of methods in clinical chemistry with particular application to those measuring enzyme activities. Part II: analysis of data and performance assessment. | Recommendations are made concerning the editing of day-to-day reproducibility data for establishment of precision in the evaluation of a clinical chemistry method. The concept of diagnostic and equalized diagnostic indices is introduced together with formulae for their generation from the usual precision and accuracy d... | 737,849 | [
-0.2085735,
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0.01495613,
0.09512495,
0.2847822,
0.08423986,
0.3321978,
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-0.002090038,
-0.3144727,
0.4145738,
0.2193034,
0.05055648,
-0.1632537,... |
Aeration in chronic otitis media. | The mastoid air cell system must be looked upon as an air reservoir. The tympanic membrane is an air pressure regulator. The smaller the air volume of the mastoid the more pronounced is the volume displacement of the tympanic membrane. The more inefficient the Eustachian tube function, the more pronounced is the tympan... | 737,862 | [
-0.3371968,
-0.1629243,
0.06980415,
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-0.3372103,
-0.2002536,
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0.02218192,
0.2704884,
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0.1800311,
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-0.419019,
-0.4418988,
0.2968636,
-0.006673011,
0.07... |
Activation of the alternate complement pathway in Staph. aureus infective endocarditis and its relationship to thrombocytopenia, coagulation abnormalities, and acute glomerulonephritis. | Twenty-four patients with infective endocarditis (IE) are described, fourteen with Staph. aureus and ten with other organisms. Despite the acute nature of the infection, ten of the fourteen with Staph. aureus IE were hypocomplementaemic; six of these ten had normal levels of C4 associated with low C3 levels, suggesting... | 737,901 | [
-0.5291401,
-0.1167751,
-0.08225702,
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0.002314474,
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0.08673918,
0.1332996,
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0.345209,
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0.5282397,
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-0.2601808,
-0.4535206,
0.07067242,
0.2417977,
0.3180393,
-0.076974... |
Damaged membrane fragments and immune complexes in the blood of patients with Behcet's syndrome. | Electron microscopic examination of centrifuged pellets of serum from patients with Behcet's syndrome and recurrent oral ulcers revealed the presence of a large number of membrane fragments. Some of these membranes showed numerous 10 nm holes that were identical to lesions produced by the action of complement. An attem... | 737,904 | [
-0.06848999,
-0.09681205,
0.156923,
-0.05779426,
0.1790065,
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0.09234009,
0.1335889,
0.4146129,
0.1238578,
0.0166124,
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-0.3320973,
0.3012554,
0.3122213,
0.5375646,
0.2113392,
-0.05634113,
... |
Lethal chondrodysplasia punctata. | The radiological findings in five infants, with chondrodysplasia punctata, who died during the neonatal period are presented to illustrate the role of radiology in diagnosis and prognosis in this syndrome. Rhizomelic shortening of the limbs almost inevitably indicates an early demise. In the non-rhizomelic group, featu... | 737,958 | [
-0.08348243,
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0.2364019,
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0.3702987,
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0.1378812,
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0.1990391,
-0.2057512,
0.1932318,
-0.01089817,
-0.03516762,
0.4535987,
0.3117648,
0.0709991... |
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