title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Hemodynamic effects of phentolamine in valvular abnormalities. | Seven patients with mitral insufficiency and seven patients with aortic insufficiency were studied by right and left heart catheterization. Hemodynamic observations were made during a control period and during the infusion of phentolamine. Significant declines in the pulmonary artery mean pressure, left ventricular end... | 742,729 | [
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A new allele in the prealbumin system of horse serum markers. | A family study of an index case in the Arabian breed of horses demonstrated the presence of a new allele in the prealbumin (Pr) system of electrophoretically determined markers in horse serum which, when homozygous, results in the absence of any recognizable zones in the Pr region. The symbol PrO is proposed for this a... | 742,740 | [
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[Traumatic amputation of the testicle. Successful reimplantation using microsurgery (author's transl)]. | A case of traumatic amputation of the left testicle with complete avulsion of the spermatic cord in a three year old boy is presented. A successful reimplantation was performed using microsurgical technique. We believe this is the first case reported in the world Literature. | 742,770 | [
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[Transsexualism]. | According to the literature, the transsexual phenomenon can be assessed as a distinct psychiatric illness. Transsexualism, a rare but spectacular disorder, realizes a gender identity reversal raising questions regarding systems of psychiatric diagnosis, nosology and treatment. A better clinical knowledge of this "exper... | 742,786 | [
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Ectopic pregnancy. Relationship to the preceding contraception. | The incidence of extrauterine pregnancies in all the deliveries in this clinic has increased from 1.3% in 1968 to 2.5% in 1976. Of 163 consecutive extrauterine pregnancies during a ten month period in 1976, 40% had an intrauterine contraceptive device in situ at the time of conception. 650 healthy women who had had an ... | 742,820 | [
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The effect of tranexamic acid on the fibrinolytic activity of vein walls. | 16 patients were treated with the fibrinolytic inhibitor tranexamic acid in an initial i.v. dose of 1 g followed by an oral dose of 4 g a day for one week and 3 g a day for two weeks. Biopsy specimens of superficial veins were obtained before and on the last day of treatment and examined histochemically for their fibri... | 742,821 | [
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Concomitant groin hernia. | The incidence and significance of concomitant groin hernias were evaluated in a prospective study of 278 adult patients with an inguinal or femoral hernia. The material was collected in the three years 1975--77 and consisted of 290 electively operated groin hernias. The incidence of various combinations of primary ingu... | 742,823 | [
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Liver blood flow after liver hilus dearterialization. | Changes in liver blood flow immediately after and during one week after a standardized liver hilus dearterialization were studied in a series of 16 dogs. An additional six dogs were sham-operated and used as controls. The liver blood flow was measured using Xe133 injections administered by two methods in every animal: ... | 742,825 | [
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The genetic and demographic impact of immigrants in a largely endogamous community. | Historical demographic data extending back approximately 300 years were analysed to determine the demographic and genetic impact of in-migrants to an endogamous Swiss Alpine village. In-migrants were involved in only 14% of the marriages recorded in the village. In addition, only slightly more than 50% of the in-migran... | 742,839 | [
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The use of discriminant analysis to define obesity in children aged 7-11 years. | All the elementary schoolchildren (ages 7-11 years) in the city of Aosta were diagnosed clinically for obesity and measured for height, weight and triceps and subscapular skinfolds. A statistical discriminant analysis revealed that, on the basis of these measurements, this population of children could be divided into a... | 742,843 | [
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The distribution of immunoglobin allotypes in two Tlaxcaltecan populations. | The distribution of Glm(f, z, a, and x), G3m(b0, b1, b3, b5, c3, c5, g, s, t and v), A2m(1 and 2) and Km(1) (formerly Inv(1)) allotypic determinants has been examined in specimens from the inhabitants of two transplanted Tlaxcaltecan villages (Cuanalan and Saltillo). The results indicate that Gmza;g Am1, Gmza;g Am2, Gm... | 742,845 | [
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Comparison of the in vitro activities of HR756 with cephalothin, cefoxitin, and cefamandole. | The in vitro activity of HR756, a new semisynthetic cephalosporin, was compared with the activities of cephalothin, cefoxitin, and cefamandole against 1,535 isolates of gram-positive and gram-negative bacteria. HR756 was less active than cephalothin and cefamandole and twofold more active than cefoxitin against Staphyl... | 742,875 | [
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[Personal experience in the surgical correction of orthostatic or stress urinary incontinence in both sexes]. | The authors present their personal experience in the surgical correcting of exertion incontinence in both sexes over the last three years, pointing out the simplicity of the aponeurotic suspension of the neck of the bladder in women and Gregoir and Puigvert's techniques in men, the latter operations being performed fir... | 742,917 | [
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[Incrusted cystitis]. | Five cases are presented of incrusted, alkaline cystitis and the authors point out the pathogenic aspects and the etiology of this illness and comment upon the two forms of endoscopic presentation and the treatment of the general and local kinds. | 742,920 | [
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[Evaluation of gammagraphy in the differential diagnosis of cysts and renal tumors]. | In view of the problems posed by the diagnosis of intrarenal masses, the authors review 16 cases of patients with this pathology who have undergone renographic and gammagraphic studies. They obtain a high level of coincidence between the gammagraphic diagnosis and its subsequent surgical confirmation, a fact which indi... | 742,925 | [
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Sperm antibody testing in infertile men. | Six hundred male patients were examined for circulating spermagglutinating antibodies by the Kibrick sperm-agglutination test and 20% demonstrated autoantibodies. The high incidence of positive findings may be explained by the select population studied. Of 80 men tested who demonstrated more than 10% agglutination in t... | 742,937 | [
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Corrective surgery of obstructive azoospermia. | Obstructive azoospermia was corrected surgically in 233 cases of vasovasotomy and 97 cases of post-inflammatory epididymovasostomy. Good results were obtained for groups of: younger age; shorter duration of obstruction; bilateral vas-to-vas anastomosis level; bilateral end-to-end anastomosis technique; bilateral oozes;... | 742,938 | [
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The effect of human spermatozoa on antigen and mitogen induced blastogenesis. | In an attempt to identify factors capable of specifically or nonspecifically modulating results in an in vitro blastogenic assay system, studies were performed evaluating cell mediated immune response to human spermatozoa. Spermatozoa were capable, on a dose dependent basis, of both inhibiting and stimulating normal ly... | 742,945 | [
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Heterosexual experience, marital status, and orientation of homosexual males. | The penile volume responses of homosexual males to pictures of nude women and men were measured and related to the subjects' marital status and experience of heterosexual intercourse. Single subjects with no experience of heterosexual intercourse and married subjects with a history of intercourse with only their wives ... | 742,966 | [
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Group vs. couple treatment of sexual dysfunctions. | Results of a study comparing the effectiveness of two formats for treating men with premature ejaculation and their female partners with orgasmic dysfunctions are described. In one treatment format, a couple was treated by a male and female cotherapy team once a week for 12 sessions. In the second treatment format, whi... | 742,968 | [
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[Glucose content of lambs' blood. 2. Blood glucose content during several hours after feeding]. | During a 16-hour fasting period, the development of the blood glucose level of ewelessly reared lambs of 4 to 30 days of age was analysed. While the blood glucose level of lambs during their first week of life reacted with a considerable increase and a relatively quick decrease on the administration of milk substitutes... | 742,972 | [
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[Interaction among the trace elements zinc, copper and iron after depletion and repletion of dairy cows with zinc]. | Imbalances in the supply with trace elements may be caused by the excessive administration of one or several elements or the insufficient administration in relation to other trace elements. This article deals with the interactions between the trace elements zinc and copper resp. zinc and iron under the conditions of th... | 742,974 | [
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[Modeling cerebral dropsy (hydrocephalus) in animals by using angiotensin II]. | The effect of a synthetic polypeptic hormone angiotensin-II on the structure of the brain ventricular system was studied in rats. A single injection of angiotensin-II, firm "Ciba", was given to rats in a dose of 0.05 mg/kg of body weight on the 1, 3, 7, 14 and 21st days. The brain was extirpated 15 min after the last i... | 742,982 | [
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Sorbent membranes: device designs, evaluations and potential applications. | The Enka sorbent membranes are designed to meet the requirements for the chronic extracorporeal treatment of body fluids with sorbents. The various configurations allow the construction of devices employing sorption alone, sorption plus filtration, or sorption plus filtration and dialysis. While conventional device des... | 743,007 | [
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The establishment of a laboratory colony of Ixodes holocyclus. | A laboratory colony capable of producing annually 3000 female Ixodes holocyclus was maintained for 3 years. Guinea-pigs were used for larval feeding and bandicoots for nymphs and adults. The methods and equipment employed are described in detail. | 743,048 | [
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Experimental infection of 35, 50 and 60 day old pig foetuses with porcine parvovirus. | Foetuses of six seronegative gilts, two of which each respectively 35, 50 and 60 days pregnant, were inoculated intrauterinely with porcine parvovirus (PPV) and examined 7 and 11 days after inoculation. HI antibody was not detected in any of the foetuses although all but one gilt developed low levels of antibody. All b... | 743,053 | [
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Purification and properties of arginase from human liver and erythrocytes. | Arginase was isolated from human liver and erythrocytes. The purification procedure used acetone precipitation, heat-treatment, (NH4)2SO4 precipitation, DEAE-cellulose chromatography and gel filtration on Sephadex G-200 in the presence of 2-mercaptoethanol. Both enzymes migrated to the anode at pH8.3 on polyacrylamide-... | 743,206 | [
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Generalized microscopic reversibility, kinetic co-operativity of enzymes and evolution. | Generalized microscopic reversibility implies that the apparent rate of any catalytic process in a complex mechanism is paralleled by substrate desorption in such a way that this ratio is held constant within the reaction mechanism [Whitehead (1976) Biochem. J. 159, 449--456]. The physical and evolutionary significance... | 743,234 | [
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0.4353958,
0.04933962,
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... |
Cell-free synthesis of metallothionein directed by rat liver polyadenylated messenger ribonucleic acid. | Total RNA was isolated from rat liver polyribosomes and fractionated by oligo(dT)-cellulose chromatography to obtain polyadenylated mRNA. The mRNA was translated in a wheat-germ cell-free protein-synthesizing system containing [3H]glycine, [3H]lysine and [3H]serine. Most of the newly synthesized 3H-labelled polypeptide... | 743,236 | [
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0.12... |
The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain. | 1. Lysosomes from rat liver contain two enzymic systems for hydrolysing phosphatidyl-inositol: a deacylation via lysophosphatidylinositol producing glycerophosphoinositol and non-esterified fatty acid, and a phospholipase C-like cleavage into inositol 1-phosphate and diaclygycerol. 2. The separate enzyme systems involv... | 743,253 | [
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[Epilepsy and the driver's license]. | 143 older than 18 years epileptic patients have been considered under the concers of their driving licence. The 33,5% of them was already in hold it. Epilepsy was under different clinical forms. The majority of the subjects would suffer from generalized primary suizures, otherwise from partial fits, either elementar or... | 743,327 | [
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[Acute bacterial nephritis in diabetics (author's transl)]. | The AA. describe an unusual form of severe grahm negative bacterial infection of the renal parenchima that occurs infrequently in adult patients, most of whom are diabetics. During the acute phase, the kidney becomes smoothly enlarged, with marked impairment of contrast material excretion. The urographic and echographi... | 743,337 | [
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The erythropoietic role of the heart in catfish (ictalurus melas). | In Catfish, the kidney is the hemopoietic organ. On heart imprints of Catfishes, there were observed cells of the hemopoietic series. In this work it was studied how much the heart can intervene in the erythropoietic process. In normal animals the heart intervenes as a erythropoietic organ in the spring when the hemopo... | 743,480 | [
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Inactivation of prostaglandin E2 in the stomach of pregnant and oestrogen pretreated rats. | The stomach of pregnant and oestrogen pretreated female rats were found to inactivate significantly exogenous PGE2 when administered orally. The mean basal acid output of pregnant and oestrogen pretreated female rats were also diminished by oral infusion of PGE2. Though the exact mechanism for these phenomena cannot be... | 743,485 | [
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Relationship between oestrogen-receptor content and histological grade in human primary breast tumours. | A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only in women defined as ... | 743,491 | [
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[Characteristics of lactate dehydrogenase isoenzymes of loach differentiated tissues and eggs]. | The degree of inhibition by pyruvate, oxalate and urea was determined for the lactate dehydrogenase (EC 1.1.1.27) of some tissues of adult loach (Misgurnus fossilis) and for the lactate dehydrogenase isozymes, which were resistant to the inhibition by AgNO3 and dominated by their activity in the unfertilized eggs of th... | 743,508 | [
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0.1870... |
Biosynthesis of protein by the retina. The properties of a cell-free system obtained from rat retina. | We describe the properties of a post-mitochondrial (30,000 g) supernatant fluid obtained from rat retina which incorporated (3H) leucine into an alkali-stable acid-insoluble fraction (protein). It contained a substance, possibly leucine, which interfered with the incorporation of (3H) leucine into acid-insoluble fracti... | 743,608 | [
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... |
Corneal effects of intraocular air. | To resolve the apparent contradiction between Norn's work on human eyes suggesting that postoperative air protects the corneal endothelium and the work of Leibowitz on excised animal eyes suggesting that air damages the corneal endothelium, we have replicated Norn's findings in an animal model similar to that used by L... | 743,609 | [
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Hepatic glucose balance in response to direct stimulation of sympathetic nerves in the intact liver of cats. | Changes in hepatic glucose balance in response to direct stimulation of the hepatic nerves were measured in cats. Simultaneous measurements were made of glucose concentrations entering and leaving the intact liver; this, combined with measured blood flows, allows calculation of hepatic glucose balance. Stimulation of t... | 743,618 | [
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Evidence for enhanced Na transport in hypertension induced by DOCA in the rat. | Uninephrectomized rats were treated with DOCA-saline for 3 weeks. Active Na transport activity was assessed in the rat tail artery in three separate ways. In the first method, Na-K exchange was expressed in terms of steady-state values in normal and ouabain-blocked arteries. In the second method, the relation of free c... | 743,619 | [
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Inhibition of gamma-aminobutyric acid uptake into astrocytes by pentobarbital. | Pentobarbital (0.5-2mM), but not phenobarbital, was found to inhibit the uptake of gamma-aminobutyric acid into mouse astrocytes in primary cultures up to 45%. This inhibition was additive to a reduction in uptake rate caused by excess potassium. Its possible role in the pharmacological action of pentobarbital is discu... | 743,628 | [
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A new approach to the measurement of glycerol turnover. | These studies describe a new method, using a single bolus injection of labelled glycerol, to measure glycerol turnover. In a series of experiments utilizing single animals, this new approach was compared with the previously used method of constant tracer infusion. The two gave identical results. In the bolus method, on... | 743,632 | [
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0.1125016... |
[Effect of fatty acids on the antibacterial activity of butylated hydroxytoluene (BHT)]. | This study deals with the effect of the association of certain fatty acids with butylhydroxytoluene (BHT) on the antibacterial activity of this antioxidant. Evidence is drawn from the results as to an increase of the inhibitory effect of the antioxidant towards a few bacterial strains when it is associated with either ... | 743,642 | [
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Pseudomembranous colitis: isolation of two species of cytotoxic clostridia and successful treatment with vancomycin. | Lincomycin-resistant Clostridium sporogenes obtained from the stools of a patient with lincomycin-associated pseudomembranous colitis produced a heat-stable cytotoxin in low titre when grown in chopped meat medium. Vancomycin eradicated this strain and all other clostridia, and controlled the symptoms. When diarrhea re... | 743,667 | [
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Evaluation of the OSM2 hemoximeter. | The linearity and repeatability of measurements of total haemoglobin concentration ([Hb]) and oxygen saturation (So2) by the OSM2 oximeter have been studied. Standard deviations (SD) of measurements from linearity were as follows: [Hb], 4.2 g . litre-1; So2, 1.14 to 1.08% between zero and 100% saturation. Reproducibili... | 743,697 | [
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Cytological characteristics and classification of spindle inhibitors according to their effects on segmentation mitoses. | The effects of spindle inhibitors and of protein synthesis inhibitors on segmentation mitoses allow us to classify them into six groups : 1. Colchicine type : destruction of the whole achromatic apparatus and centrospheres without storing of dense bodies; 2. Quinoline type : same effect on the achromatic apparatus, but... | 743,732 | [
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0.144... |
[Preliminary report on the demonstration of resistance to coumafene in Rattus rattus in Marseilles]. | An abnormal proliferation of Rattus rattus in an important food-products warehouse in Marseille's periportuary zone has been recorded in spite of preventative measures put in place and aimed at testing these rodents resistance to basic anticoagulants, especially to coumafene. The laboratory experiments on animals taken... | 743,770 | [
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[Intestinal parasitoses in the child in French Guiana. Evaluation of a 4-year systematical survey in the C.H. of Cayenne]. | A systematic study on intestinal parasites in children of the Cayenne Hospital Center from 1974 to 1977 showed the following: 1(0) With a 26.1 0/0 total infestation index, nematodes are four times more frequently more responsible than protozoa; cestodes are extremely rare (T. saginata 0.8 0/0); trematodes are found onl... | 743,775 | [
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Cholesteatoma in children: is the disease different in childhood? | During the early phase of the development of the temporal bone the correlation between the bone growth and the formation of the air-filled spaces--disturbed or undisturbed--is decisive for development of even hidden and neglected forms of middle ear cholesteatomata. The second phase of the development of the temporal b... | 743,780 | [
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0.01987... |
[Presence of microfilariae in the anterior chamber of the eye onchocerciasis]. | Observation of a patient presenting 34 microfilariae in the anterior chamber of one eye, with negative biopsies, two small nodules and punctiform onchocercosis keratitis elementary microlesions. The patient has been observed five times during more than one hour each time. The author reviews the results of different sur... | 743,777 | [
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... |
Total hip arthroplasty for failed endoprostheses. | Ninety total hip Charnley arthroplasties were performed in 80 patients with failed endoprostheses between July, 1970, and November, 1975. Pain was completely alleviated or minimal in 97.7% of cases. The ability to ambulate improved in all cases with 93.2% good or excellent results. Low grade infection must be considere... | 743,814 | [
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The natural history of congenital dislocation of the hip: a critical review. | Studies of the natural history of congenital dislocation of the hip do not distinguish which particular features indicate a poor prognosis. In complete dislocation we have found that the development of a false acetabulum with thick sclerotic iliac bone more frequently leads to pain than those with little or no bony rea... | 743,823 | [
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Functional results of iliopsoas transfer in myelomeningocele hip dislocations. | Paralytic hip dislocations in 37 children with myelomeningoceles have been treated by open reduction, iliopsoas tendon transfer and various other procedures about the hip. At follow-up, less than half the patients were community ambulators and had maintained their reductions. The level of the spinal lesion, alignment o... | 743,827 | [
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0.1304981,
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Revascularization and replantation after upper extremity trauma: experience with interposition artery and vein grafts. | Improved techniques and experience in microvascular surgery make it possible to repair vessels and replant digits and extremities with increasing success. Patients with sharp or localized crush injuries are excellent candidates, and the expected survival of the extremities is greater than 80%. A good functional result ... | 743,833 | [
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The result of replacement of partial or total collateral ligaments with Marlex mesh in the knees of dogs. | Marlex mesh is a synthetic material which has been used clinically to replace ligamentous structures. It serves as a scaffold for infiltration of the fibroblasts eventually becoming mature fibrocytes. In dogs, almost totally mature fibrocytes appear within the framework of the Marlex mesh prosthesis by the end of 3 mon... | 743,840 | [
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... |
Intraoperative femur fractures during total hip replacement. | Eleven intraoperative femur fractures occurred during 605 total hip replacements at Rancho Los Amigos Hospital, an incidence of 1.8%. Fractures occur more often in women, are usually located in the proximal femur, and mostly occur during femoral reaming. The main predisposing factors were osteoporosis and previous hip ... | 743,850 | [
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0.2840834,
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0.2166451,
0.02084981,
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... |
Methyl ethyl ketone polyneuropathy in shoe factory workers. | Three cases of polyneuropathy in shoe factory workers are described. The etiologic agent is felt to be methyl ketone, a substance previously thought to be a safe solvent. The concentration of this substance in the ambient air of the patients was below the threshold limit value. This suggests that there may be a cumulat... | 743,866 | [
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0.4195335,
0.05358289... |
Phototoxicity of Dictamnus alba. | Phytophotodermatitis from Dictamnus alba was observed in three patients. Thin-layer chromatography and spectrophotometry disclosed the occurrence of 5-methoxypsoralen and 8-methoxypsoralen in the plant extracts which was also demonstrated by their phototoxic activity in vitro. | 743,873 | [
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Absence of satellite DNA synthesis during meiotic prophase in mouse and human spermatocytes. | Mouse spermatocytes were labelled in situ with 3H-thymidine at successive stages of meiosis. Isolated mouse as well as human spermatocytes were similarly labelled under in vitro conditions. DNA synthesis was followed either by tracking radioactivities in Cs2SO4 gradients or by measuring reassociation kinetics. Mouse sa... | 743,902 | [
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[Schizophrenia and addiction]. | The relationship between schizophrenia and drug abuse has been approached using physiopathological, psychopathological, and cybernetics communicational techniques. The hypotheses which have been proposed with regard to the physiological mechanism involved in schizophrenia and drug abuse all have in common, among other ... | 743,940 | [
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Acute effects of thyroid-stimulating hormone on cultured thyroid cell morphology. | The acute effect of TSH on the ultrastructure of dog thyroid cells in monolayer tissue culture was examined by scanning electron microscopy. Although thyroid cells in monolayer culture remained responsive to TSH stimulation, the cell surface changes induced by TSH were different from those seen in intact thyroid tissue... | 743,946 | [
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Estrogen and progesterone interactions in the rabbit uterus in vivo after steroid administration. | After a single injection of Estradurin (polyestradiolphosphate), rabbit plasma 17 beta-estradiol (E2) levels rose to a maximum in 3 days and were maintained for at least a 13-day period. The uterine E2 concentration rose slowly so that at day 12 the tissue/plasma E2 ratio was similar to that in untreated controls. The ... | 743,952 | [
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0.3190865,
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Aromatase activity in the developing rabbit brain. | The formation of 17beta-[3H]estradiol from [1,2,6,7-3H]testosterone was assessed in placenta and central nervous system tissues from rabbit embryos that varied in age from 13-28 days of gestation. In the fetal brain, significant rates of aromatase activity were limited exclusively to the forebrain, and the highest rate... | 743,958 | [
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Electrophoretically separable forms of rat prolactin with different bioassay and radioimmunoassay activities. | The possible existence of forms of rat PRL with different bioassay (BA)/RIA activity ratios was investigated. Anterior pituitary tissue and medium in which explants of rat adenohypophyses had been incubated were processed by polyacrylamide disc gel electrophoresis using a Tris-glycine buffer. The gel columns were cut i... | 743,965 | [
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Preprogramming mechanism of luteinizing hormone in the determination of the lifespan of the rat corpus luteum. | Luteal regression was studied in female rats bearing an isografted pituitary under the renal capsule and the day of ovulation was designated as day 0. These females had pseudopregnancy-like cycles and ovulations at 16-day intervals. After each ovulation, corpora lutea were activated and progesterone concentrations incr... | 743,971 | [
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0.3824055,
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Serum somatomedin stimulation in thyroxine-treated hypophysectomized rats. | Somatomedin activity in rat serum was measured by sulfate incorporation into embryonic chick cartilage. Hypophysectomized male rats were treated daily for 21 days with 20 microgram/kg L-thyroxine (T4) and/or 25 microgram bovine (b) GH. Serum from rats given T4 alone or with bGH had somatomedin potencies of 0.88 and 0.8... | 743,982 | [
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-0.072328... |
Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen. | Intra-ovarian Silastic implants containing the antiandrogen, Flutamide, or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis du... | 744,003 | [
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... |
Suppression of liver cell proliferation by glucocorticoid hormone: a comparison of normally growing and regenerating tissue in the immature rat. | The influence of glucocorticoid hormone on the time-course of liver regeneration in the immature rat has been studied by direct measurement of the rate of DNA accretion after the stimulus of partial hepatectomy. In contrast to hepatocyte proliferation associated with normal growth, which almost completely abolished by ... | 744,011 | [
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Effect of glucagon and insulin on the growth of neonatal rat hepatocytes in primary tissue culture. | Commercial (bovine-porcine) glucagon added in a single dose between 10(-12) and 10(-7) M to neonatal rat hepatocytes in primary cultures with subsequent incubation for 20-24 h, stimulated their entry into the DNA synthesis phase as revealed by [3H]thymidine-labeling and radioautography; about 14 h of incubation was req... | 744,015 | [
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-... |
Role of intraluteal estrogen in the regulation of the rat corpus luteum during pregnancy. | The pronounced aromatizing ability of the rat corpus luteum and the ability of estradiol to maintain luteal function. To examine this hypothesis, rats were treated with either estradiol (100 microgram/day), high or low levels of testosterone via Silastic capsules (20 cm or 1 cm in length), or dihydrotestosterone (20-cm... | 744,016 | [
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... |
A cytoplasmic progesterone receptor in hen pituitary and hypothalamic tissues. | The cytosol fraction of the anterior lobe of the pituitary in laying White Leghorn hens was shown to possess a progesterone-binding component which perferentially bound progesterone. A similar component was also found in the cytosol of the hypothalamus and of the oviduct magnum. The dissociation constant (Kd) at equili... | 744,018 | [
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... |
Accumulation and localization of radiocalcium in the rat thyroid gland. | To determine the rate of accumulation of radiocalcium (45Ca) in the thyroid gland, the concentration of radiocalcium was measured in the blood serum and thyroid gland at various time intervals up to 7 days after a single ip injection of 45Ca in rats. The ratio of the 45Ca concentration in thyroid gland to serum (T:S) i... | 744,035 | [
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... |
Effect of pregnant mare's serum gonadotrophin on the activities of delta 4-5 alpha-reductase, aromatase, and other enzymes in the ovaries of immature rats. | After incubation of progesterone, 17 alpha-hydroxyprogesterone, androstenedione, and testostrone with an ovarian preparation (supernatant fluid at 10,000 x g) of immature rats (21-23 days of age) in the presence of NADPH, 3 alpha- and 3 beta-hydroxy-5 alpha-reduced steroids were obtained as the major metabolites. Among... | 744,041 | [
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Adrenal steroidogenesis in methylandrostenediol-induced hypertension. | Adrenal vein catheterizations were done in rats made hypertensive by administration of methylandrostenediol (MAD; 17alpha-methyl-5-androstene-3beta,-17beta-diol), and in control rats at intervals during treatment. All MAD-treated rats were hypertensive by 7 weeks. Secretion of corticosterone was consistently decreased ... | 744,061 | [
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0.09... |
Changes in the fetal thyroid axis after induction of premature parturition by low dose continuous intravascular cortisol infusion to the fetal sheep at 130 days of gestation. | The effect of cortisol infusion on plasma T4 and T3 concentrations has been investigated in the fetal lamb at 130-134 days of gestation. Infusion of cortisol at rates equivalent to one-third the quantity produced by the fetus at the time of parturition results in a significant fall in fetal plasma T4 concentration and ... | 744,069 | [
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The biphasic regulation of prolactin secretion by dopamine agonist-antagonists. | The in vitro secretion of PRL by the pituitary gland is inhibited by low concentrations of dopamine. Dopamine receptor-blocking agents, haloperidol and pimozide, in concentrations between 10-100 nM, neutralize virtually completely the dopamine-mediated inhibition of PRL secretion. At these concentrations, the dopamine ... | 744,072 | [
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0.1984029,
0.1428046,
0.0318409... |
Subcellular distribution of thyroxine 5'-deiodinase in the rat kidney: a plasma membrane location. | The enzymatic activity in rat kidney homogenates mediating the conversion of T4 to T2 has been previously shown to be particulate. The subcellular organelle responsible for T4 5'-deiodination, however, has not been identified. Enzymatic activity was assessed with outer ring 125I-labeled L-T4 as the substrate and the io... | 744,079 | [
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... |
Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat. | Young adult cyclic female rats were each injected with 2 mg estradiol valerate (EV) in sesame oil. Controls received an equivalent volume of sesame oil. Within 2 months after injection, most of the EV-treated animals showed persistent vaginal estrus and small polyfollicular ovaries as well as pathological changes in th... | 744,098 | [
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Effect of castration and steroid replacement on immunoreactive luteinizing hormone cells in the pars tuberalis of the rat. | The response of LH cells in the pars tuberalis of the rat hypophysis to castration alone or castration and subsequent administration of testosterone propionate or estradiol benzoate was studied. To accomplish this, LH cells were labeled by the peroxidase-antiperoxidase immunocytochemical method, with use of an antiseru... | 744,103 | [
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... |
Inhibition by adenosine of thyroidal T4 release in vitro. | Adenosine, like catecholamines, inhibits the thyroidal T4 release in vitro, when stimulated by TSH,N,O'-dibutyryl cyclic AMP [(Bu) 2cAMP], and phosphodiesterase inhibitors. Unlike catecholamines, the adenosine-induced inhibition is independent of adrenergic receptors. It is postulated that TSH stimulates thyroidal T4 r... | 744,109 | [
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Physical properties of androgen receptors in brain cytosol from normal and testicular feminized (Tfm/y hermaphrodite) mice. | Our previous results had shown that brain cytosol from androgen-insensitive, testicular feminized (Tfm/y) mice contains a reduced amount (20-25%) of androgen receptors, compared to normal female or castrated male mice, with unchanged affinity for dihydrotestosterone (DHT). We have now used various physicochemical techn... | 744,116 | [
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... |
Effect of parturition on serum iodothyronine concentrations in fetal sheep. | T4, T3, and rT3 were determined by RIA on daily serum samples collected from five catheterized fetal sheep during the 2-week period before spontaneous vaginal delivery (PTD). Samples were also available from three newborn lambs during the first 4 h of life. T3 concentrations began to increase 4-6 days before spontaneou... | 744,158 | [
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Angiotensin II concentration in cerebrospinal fluid after intraventricular injection of angiotensinogen or renin. | To determine if the brain enzyme which has renin-like activity in vitro can form angiotensin in vivo, angiotensin II concentration in cerebrospinal fluid (CSF) was measured before and at various intervals after injection of partially purified renin substrate (angiotensinogen) into the third cerebral ventricle of anesth... | 744,161 | [
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0.01134943,
0.08194927,
-... |
Hypothalamo-hypophyseal-gonadal system in male rats and guinea pigs treated with the antiandrogen 4-nitro-3-trifluoromethylisobutyranilide. | Influence of the competitive testosterone antagonist 4-nitro-3-trifluoromethylisobutyranilide (NFBA) on the hypothalamo-hypophyseal-gonadal system in male Wistar rats and guinea pigs was studied. NFBA as well as nonlabelled testosterone diminished 3H-testosterone uptake in hypothalamus and hypophysis of castrated anima... | 744,175 | [
-0.03124362,
0.07378631,
0.0164251,
0.04448961,
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0.129484,
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0.2288605,
0.2770816,
0.5719146,
0.0846772,
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The nephrotoxicity and renal accumulation of amikacin, tobramycin and gentamycin in rats, rabbits and guinea pigs. | The nephrotoxicity and renal concentrations of amikacin, tobramycin and gentamycin were studied in rat, rabbit and guinea pig. The nephrotoxicity was estimated by histological examination and by measuring the relative weight of the kidneys (mg/100 mg body weight). These two systems had a significant correlation (r = 0.... | 744,211 | [
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0.2428335,
0.06944619,
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0.4288527,
0.01439055,
0.1536859,
0... |
Keith: a case study of structural family therapy. | This is an edited case presentation of marital therapy of a couple whose child was originally presented as the problem. Two primary themes are emphasized throughout the case. The first is that therapy consists of stages involving critical transitional points that need to be appropriately timed. The second is the use of... | 744,221 | [
-0.3664617,
0.2672075,
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0.03378794,
0.3212691,
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0.01664929,
0.1184797,
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0.... |
Family interaction and communication deviance in disturbed and normal families. Confusions and conclusions: a response to Doane. | The purpose of this paper is to evaluate critically the logic and conclusions of Doane's article (14), and in so doing, to raise serious questions regarding her evaluation of the family interaction literature. In particular, we suggest that Doane's paper is characterized by (a) a confused and inaccurate presentation of... | 744,222 | [
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0.1385852,
-0.07355... |
[Biological activity of 1,2-benzylisothiazoles. Relationship between the structure and the auxinlike activity of the 1,2-benzylisothiazol-3-ylacetic acid class]. | The LFER model was used to study quantitatively the interrelations between chemical structure and auxinic activity of some methyl esters of 1,2-benzisothiazol-3-ylacetic acids, using as biological response the cell enlargement induced in etiolated stems of Pisum sativum, var. Alaska. Having demonstrated that activity, ... | 744,234 | [
0.0005597199,
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0.1616183,
0.1174719,
0.3223943,
0.2290143,
0.04335647,
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-... |
[Metabolism of vincamine in the rat]. | The metabolism of vincamine hydrochloride was studied in the rat after oral administration of the drug. Vincamine is almost completely metabolized, only a small fraction of the original compound being excreted in the urine. The metabolites detected in blood, urine and tissues were purified by preparative thin layer and... | 744,256 | [
-0.02928907,
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0.5667067,
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0.3897281,
0.1188098,
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... |
The binding of 8-methoxypsoralen by human serum albumin. | The ability of 8-methoxypsoralen (8-MOP) to bind human serum albumin has been investigated in vitro through equilibrium dialysis and fluorescence quenching. By means of the first technique it was observed that, at concentrations presumably close to those obtainable in vivo following its administration in the photochemo... | 744,263 | [
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0.4293503,
0.2968453,
0.06358311,
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... |
[Phytotoxic activity of asymmetric N,N-dialkylnaphthamides]. | Asymmetric N,N-dialkylnaphthamides, prepared and tested in pre- and post-emergence tests against some representative weeds, showed good or excellent phytotoxicity often with selectivity of action against Echinochloa and Setaria. These amides are characterized by the presence on the amide nitrogen of a sec.butyl or a 1-... | 744,265 | [
-0.2508504,
0.160448,
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0.4722435,
0.05368415,
0.3975675,
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... |
[N,N-Di-(1-ethylpropyl)amides of benzoic and naphthoic acids having phytotoxic activity]. | N,N-di-(1-ethylpropyl)amides of benzoic and naphthoic acids suitable substituted in the nucleus were prepared and tested for selective phytotoxic activity in both pre- and post-emergence tests against some weed species. All the amides tested showed good generic phytotoxicity, often with good selectivity, on absorbance ... | 744,267 | [
-0.2337129,
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0.2631483,
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0.4723793,
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... |
[Functional model of peripheral spectral auditory analysis (linear variant)]. | Peripheral auditory system model consists of several parts: the first one being representative of the middle ear and basal part of the cochlea whereas the last one involves the first neuron level of the auditory nerve. Experimental data from basilar membrane motion and auditive nerve fiber activity for sinusoidal and c... | 744,283 | [
-0.1389553,
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0.1046276,
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0.01396125,
0.4414595,
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0.1... |
Studies on orthocephalization of the rat head. I. A model system for the study of adjustive cranical growth processes. | Mammalian cephalogenesis is characterized by several morphological processes, among which are alteration in spatial position and angular relationships (flexions) between the several bones of both the neural and facial skulls, as well as similar alterations between neurocranium and splanchnocranium. Prior classification... | 744,460 | [
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0.5109257,
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0.01433048,
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0.05771428,
0.1196779,... |
Histochemical and ultrastructural observation of endocrine cells in pathological gastric mucosa. | Recent achievements of gastrointestinal endocrinology on the basis of new techniques enabled investigation of endocrine cells in pathological conditions. The present paper describes investigations of 56 surgical cases of the stomachs operated on for duodenal and gastric ulcer and gastric cancer. Argyrophilic cell hyper... | 744,534 | [
-0.190496,
-0.4908893,
-0.06532061,
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0.04263509,
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0.2945809,
0.5165989,
0.1189251,
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0.2474915,
0.1882594,
0.3886195,
0.04481698,
0.3646629,
-0.009652161,
-0.1416108,
... |
Study of acetylcholinesterase distribution in the various tissues of birds and mammals. | The distribution of AChE activity in the various tissues was studied, in female Funambulus pennanti (five banded squirrel), female Francolinus pondicerianus (grey partridge of safed teeter), female Perdicula asiatica (jungle bush quail or lowwa), female Gallus domesticus (white leghorn), and female Suncus murinus (Indi... | 744,541 | [
0.3350925,
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-0.332936,
-0.336436,
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0.1102086,
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-0.1905256,
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-0.2489263,
0.2668108,
0.2793539,
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-0.3522207,
-0.4190575,
0.2817917,
-0.07458335,
0.2779871,
0.1336145,
0.3430697,
-0.01141573,
... |
Ultrastructure of the adenohypophysis in the domestic pig (Sus scrofa domestica). Part I: Cells of the pars anterior. | In the hypophyses of 46-79 days old pig embryos three groups of cells were separated; one group constitute non-differentiated cells, second, cells becoming differentiated, and third, seven types of differentiated cells. Probably three of these types are equivalent to the secretory cells STH, TSH, and FSH, and one type ... | 744,543 | [
-0.3140189,
-0.3208171,
0.1870925,
-0.02669067,
-0.05731869,
-0.3857546,
0.01658526,
0.07252862,
0.05140727,
0.2057848,
0.1016894,
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0.0479682,
-0.08164072,
-0.00964509,
0.09889244,
0.3843109,
0.1960907,
-0.2889926... |
Sudden infant death syndrome in Cardiff, association with epidemic influenza and with temperature - 1955-1974. | The effects of social class, season, low temperature and sudden falls in temperature are investigated in 286 cases of Sudden Infant Death Syndrome in Cardiff in the years 1955--1974. The association with low temperature was striking: unsuspected hypothermia may be an important feature of these deaths. Sudden infant dea... | 744,671 | [
-0.3506252,
-0.04070523,
-0.1621912,
0.0353486,
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0.08393303,
0.03733929,
0.1153271,
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0.039462,
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0.08153535,
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0.2208477,
0.2003987,
0.2825173,
0.2429613,
-0.155117,
0... |
Side reactions in peptide synthesis. IX. Suppression of the formation of aminosuccinyl peptides with additives. | The base-catalyzed ring closure of beta-benzylaspartyl peptides was efficiently suppressed by the addition of phenols (with electron-withdrawing substituents) to the reaction mixtures. From a series of compounds tested, 2,4-dinitrophenol and pentachlorophenol were the most effective. No direct relationship was found be... | 744,687 | [
-0.2341727,
0.02220759,
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0.1763629,
0.06101645,
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0.1771791,
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0.1473257,
0.1441105,
0.2357284,
0.2837055,
-0.05403177,
-0.05055368,
... |
Human anthrax in Iran: an epidemiological study of 468 cases. | The study of 468 cases of cutaneous anthrax admitted to the Firoozabadi Hospital during the 13 years show that 59.83% of cases were male and 40.17% female. 42.93% of patients were below the age 30. As occupational background concerned 27.86% belongs to industrial workers. On the other hand 20.73% of cases have contract... | 744,703 | [
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0.1948206,
-0.3029964,
-0.2031338,
0.4379162,
0.117644,
0.4584871,
-0.1892412,
-0.219... |
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