title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Antigen- and receptor-driven regulatory mechanisms. II. Induction of suppressor T cells with idiotype-coupled syngeneic spleen cells. | Anti-p-azobenzenearsonate (ABA) antibodies, coupled covalently to normal syngeneic spleen cells and then given intravenously to normal animals, were found to be potent tolerogens for delayed-type hypersensitivity (DTH) to ABA. The ability of the antibody-coupled cells to induce tolerance was determined to be a result o... | 91,657 | [
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Presence of plasma cells binding autologous antibody during an immune response. | Spleen and other lymphoid tissues of rabbits immunized with human serum albumin (HSA) and human lactoferrin (LF) were examined for the presence of cells forming anti-idiotype antibodies. To detect these cells, IgG, F(ab')2, or Fab' of specific antibodies were isolated, fluorochrome-tagged with tetramethylrhodamine isot... | 91,659 | [
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Subarachnoide hemorrhage due to S. mansoni. A rare etiology. | A case of schistosomiasis is described in a native of Rio de Janeiro, where, apart from infection of the intestines, a meningitic granulomatous reaction was provoked around eggs. Intracerebral and subsequently subarachnoid hemorrhage occurred. The mode of infection is disucssed. | 91,674 | [
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Reduction in sudden deaths by a multifactorial intervention programme after acute myocardial infarction. | 375 consecutive patients below 65 years who had an acute myocardial infarction (AMI) took part in a randomised rehabilitation and secondary prevention trial (part of a W.H.O.-coordinated project) designed to study the effects of a multifactorial intervention programme on morbidity, mortality, return to work, &c. Af... | 91,836 | [
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New procedure for the production of influenza virus-specific double-stranded DNA's. | A novel technique is described for the production of pure, full-length influenza virus ds DNA's corresponding to each segment of the influenza virus genome, and suitable for molecular cloning and restriction endonuclease mapping. The method involves the synthesis of DNA complementary to both virion (negative strand) an... | 92,012 | [
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Characterization of the reverse transcriptase of a type C RNA virus produced by a human lymphoma cell line. | The reverse transcriptase (RNA-dependent DNA nucleotidyltransferase) of the type C RNA virus produced by the human lymphoma cell line SU-DHL-1 was purified by ion-exchange chromatography of SU-DHL-1 culture fluids and repetitive affinity chromatography on poly(rC).agarose, as were the polymerases of several other type ... | 92,023 | [
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Characterization of alkylamine-sensitive site in alpha 2-macroglobulin. | Methylamine reacts with the plasma protease inhibitor, alpha 2-macroglobulin, to form an irreversible, covalent modification. Quantitation of the reaction indicates 3.9 +/- (SD) 0.4 reactive sites per native tetrameric protein (Mr = 725,000) or one site per subunit. The reaction is selective and specific in that only 1... | 92,026 | [
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Arterial occlusion in the management of pain from metastatic renal carcinoma. | Arterial embolization was performed in nine patients with metastases from renal carcinoma who had severe pain resistant to conventional therapy. Patients with metastases in the ilium (four), the lumbosacral spine (one), and the base of the skull (one) experienced pain relief lasting from one to six months. The other th... | 92,038 | [
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Visualization of polymercurimethane-labeled for bacteriophage in the scanning transmission electron microscope. | Each of the 2700 coat proteins of fd bacteriophage was labeled with tetrakis(acetoxymercuri)methane (TAMM) or aquoglycylmethionineplatinum(II). The TAMM-labeled specimens reveal striking bright spots in the scanning transmission electron microscope which arise from clustering. Measurements of mass show increases consis... | 92,053 | [
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[Antibody response to hemagglutinin and neuraminidase induced by an influenza subunit vaccine (author's transl)]. | To study antigenicity, persistence of antibody (efficacy) and reactogenicity of a new bivalent influenza subunit vaccine, Sandovac, it was given in two different concentrations (1000 and 2000 IU) to 156 subjects from two epidemiologically destinct areas (119 students from Essen, average age 22 years, 37 residents from ... | 92,113 | [
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Dermatological study of 47,XYY males. | Dermatological features of five 47,XYY males are presented. Port-wine stains were observed in 2 cases. As the incidence of port-wine stains among the general population is believed to be 0.5%, this result would seem to indicate that the association of 47,XYY males with port-wine stains is more than a coincidence, thoug... | 92,153 | [
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An evaluation of cellularity in various types of bone marrow specimens. | Comparisons of marrow cellularity determinations in needle biopsy sections, aspirated smears of marrow particles, and aspirated clot sections were made using the point-counting and standard visual methods of measurement. Good correlations of cellularity between biopsies and smears were obtained with the point-counting ... | 92,191 | [
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Serous detachments of the retinal pigment epithelium in patients with senile macular disease. | Thirty-one patients had senile macular disease with serous detachments of the retinal pigment epithelium without evidence of choroidal neovascularization. Of these 31 patients the natural history of 24 eyes was compared with 21 eyes treated with photocoagulation. Eight patients with bilateral detachments had treatment ... | 92,198 | [
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Ultrastructural localization and characterization of proteoglycans in the pulmonary alveolus. | The ultrastructural identification and characterization of lung proteoglycans was studied using the polycationic dye, ruthenium red. Treating lung parenchyma with the detergent Triton X-100 increased epithelial permeability and allowed the dye to penetrate alveolar walls and stain the alveolar basement membrane and lun... | 92,209 | [
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The O antigenic relationships of Kloeckera africana, Salmonella aberdeen and Escherichia coli O75. | The immune sera for Salmonella aberdeen (O11) and Escherichia coli (O75) agglutinated Kloeckera africana strain. The immune serum for K. africana agglutinated S. aberdeen (O11) and E. coli (O75) strains. Absorption and agglutination cross-tests demonstrated common antigenic factor(s) in the tested yeast and Salmonella ... | 92,211 | [
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A prospective study of 18 infants of chronic HBsAg mothers. | 28 of 1002 pregnant Sicilian women (2.8%) were asymptomatic HBsAg chronic carriers. 18 children of these women were followed and at least 15 of them showed evidence of transplacental infection with HBsAg, resulting either from the presence of the antigen in cord blood, or from the development of the corresponding antib... | 92,218 | [
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[Orthosympathetic stimulation after hypercapnia in the rat]. | Inhalation of a gas mixture : CO2, 25% -- O2, 37.5% -- N2, 37.5%, provokes regularly in the light anaesthetized rat, an increase of catecholaminemia of central origin, associated with systemic arterial hypertension. | 92,225 | [
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Resolution of block neutralization test curves into components of the foot-and-mouth disease virus system. | Classic neutralization studies by Fazekas de St. Groth and Webster (8) on mixtures of influenza viruses and mixtures of rabbit antisera are reinterpreted in terms of a percentage contaminant in the stock used for the dilution series. A very small amount of a different virus changes the shape of quantal assay curves con... | 92,300 | [
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[Carbon monoxide: environmental and biological aspects]. | The problem of carbon monoxide as a pollutant is examined. Its physico-chemical features are considered along with the sources of pollution (natural and technological), the characteristics of the pollutant in the environment and, particularly, the effects of car and industrial emissions and of cigarette smoke on the hu... | 92,299 | [
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Salvage operations for malignant obstruction of the oesophagus. | Two patients with locally advanced carcinoma of the oesophagus, who did not obtain palliation with radiotherapy, underwent salvage operations to restore their ability to swallow. One patient was subjected to pharyngolaryngo-oesophagectomy together with excision of the involved posterior tracheal wall. Reconstruction wa... | 92,306 | [
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Feulgen-DNA content of the Purkinje neuron: "diploid" or "tetraploid"? | Microdensitometric measurements of the Feulgen-DNA content of the Purkinje cells and of the small granular cells (2c control) were carried out at lambda 550 nm and by the two wavelength method according to Fukuda et al., and were also corrected for the glare. We analysed sections of perfused cerebella and isolated cell... | 92,311 | [
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Placenta-bound immunoglobulins. | Low pH eluates were prepared from trophoblasts derived from 8 term human placentas. A qualitative analysis for immunoglobulins revealed the presence of IgG, IgA, and IgM in these eluates. IgC-rich fractions were obtained by DEAE-cellulose chromatography of ammonium sulfate-concentrated eluates. These fractions were abl... | 92,319 | [
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Effect of defaunation on the metabolism of rumen micro-organisms. | 1. Rumen contents of a fasted fistulated wether, obtained in a faunated, defaunated and refaunated period were incubated in vitro with a mixture of cellobiose and maltose, in the presence of ammonium bicarbonate and 32PO43-. Total synthesis of microbial N (Nt) was calculated from 32P incorporation and N:P determined in... | 92,340 | [
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Studies on the activation of canine trypsinogens in vitro. | The activation of canine anionic and cationic trypsinogen by enterokinase, trypsin, thrombin, plasmin and extracts from canine granulocytes were studied in vitro. Enterokinase activates both trypsinogens about 1000 times faster than trypsin. The enterokinase-catalyzed activation is not inhibited by the main serum prote... | 92,342 | [
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Reduction by reserpine of the accumulation of retrogradely transported [125I]nerve growth factor in sympathetic neurons. | Experiments were carried out to determine if stimuli which augment preganglionic nerve activity to sympathetic neurons, and thereby cause trans-synaptic induction, increase the retrograde transport of nerve growth factor (NGF). It was found that nerve activity had no effect on retrograde transport of [125I]NGF. It was ... | 92,350 | [
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Cutaneous manifestations of acute carbon monoxide poisoning. | A patient with acute carbon monoxide poisoning due to leakage of gas from the exhaust system in his automobile noted edema and blister formation over large areas of the skin of one half of his body. Rhabdomyolysis, acute but transient renal insufficiency, and hemolytic anemia developed subsequently. | 92,389 | [
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A reappraisal of palliative surgery for total anomalous pulmonary venous connection: description of a new operative technique. | The need for effective palliation of critically ill infants born with total anomalous pulmonary venous connection is reappraised. Careful study of autopsy specimens in patients with this cardiac malformation (patient ages ranging from newborn to 5 1/2 mth) revealed 4 favorable anatomic dispositions in 16 selected heart... | 92,409 | [
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[Gamma globulin in secondary antibody deficiency syndrome]. | 12 patients with secondary antibody deficiency syndrome received a new gammaglobulin compound intravenously (lyoph. SRK Sandoz). The drug was given in a 3% NaCl-solution once to four times. At the end of the infusion of 6 g gammaglobulin and after one week, serum levels were significantly higher. Gammaglobulin intraven... | 92,444 | [
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0.3716589,
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-0.3649676,
-0.3483333,
-0.1988358,
-0.09268732,
0.40627,
0.3635642,
0.02432178,
-0.02301117,
... |
Kunitz-type proteinase inhibitors derived by limited proteolysis of the inter-alpha-trypsin inhibitor, II. Characterization of a second inhibitory inactive domain by amino acid sequence determination. | A short digestion with excess of trypsin releases an inhibitor with an apparent molecular weight of 14,000 from both the inter-alpha-trypsin inhibitor and the ITI-related acid-stable inhibitor. The amino acid sequence of this inhibitor was determined. The inhibitor is composed of two covalently linked homologous Kunitz... | 92,448 | [
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0.... |
Cytochemistry of human catalase. The demonstration of hepatic and renal peroxisomes by a high temperature procedure. | The cytochemical demonstration of marker enzymes for subcellular organelles permits light microscopic analysis of their structure and function in normal and diseased tissues. Currently available staining procedures for the peroxidatic activity of catalase in peroxisomes of plant and animal cells yield weak and inconsis... | 92,501 | [
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0.4441346,
-0.2292132,... |
Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. | A sensitive method for evaluating extracellular parasite viability was used to determine the in vitro susceptibility of virulent Toxoplasma gondii to selected oxygen intermediates. By acridine orange fluorescent staining criteria, toxoplasmas were resistant to up to either 10(-3) M reagent H2O2 or H2O2 generated by glu... | 92,521 | [
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0.201948,
0... |
Primidone metabolism in renal insufficiency and acute intoxication. | Primidone (PRIM) is metabolized into phenobarbital (PB) and phenylethylmalonamide (PEMA). During anticonvulsant therapy with PRIM under normal conditions PB represents by fat the largest portion of the total concentration of all three components (PRIM + PB + PEMA). In combined therapy with diphenylhydantoin (DPH), and ... | 92,538 | [
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-0.3... |
Isotachophoresis in capillary tubes of CSF proteins -- especially gammaglobulins. | Isotachophoresis in polyacrylamide gel tubes (PAG-ITP) and in capillary tubes (Tachophor, LKB) have previously been found by the authors, to be very promising high-separation methods for CSF and serum proteins, especially regarding the diagnosis of MS. PAG-ITP methods for analytical and preparative use have been descri... | 92,549 | [
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Quantitative and qualitative changes in phospholipid in the intestine of the gerbil and the development of lipodystrophy. | Female gerbils fed a diet containing 20% coconut oil develop an intestinal lipodystrophy that is not seen in animals fed a diet containing 20% safflower oil or a diet of 20% coconut oil supplemented with 0.1% inositol. The coconut oil diets contained 1.5% safflower oil to prevent essential fatty acid deficiency. The le... | 92,556 | [
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0.06750937,
0.054498... |
Dicarboxylic acid analogs of gramicidin A: dimerization kinetics and single channel properties. | According to the model of Urry, the cation-permeable gramicidin channel is a dimeric helix formed by association of two peptide monomers linked at their amino ends. In this paper the channel properties of gramicidin analogs are described which have been obtained by chemical modification at the coupling site of the two ... | 92,570 | [
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0.4160908,
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0.2... |
Correlation between Epstein-Barr virus membrane antigen and three large cell surface glycoproteins. | A correlation between Epstein-Barr virus membrane antigen (MA) and three surface glycoproteins has been established on the basis of radio-immunoprecipitation and immunoabsorption experiments. For radio-immunoprecipitation, Epstein-Barr virus-infected cells were radiolabeled either with neuraminidase-galactose oxidase t... | 92,577 | [
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Emergence of trimethoprim-resistant enterobacteria in patients receiving long-term co-trimoxazole for the control of intractable urinary-tract infection. | In patients with previously intractable urinary-tract infection treated with low-dose co-trimoxazole for 6--58 (mean 32.7) months, the percentage of infected urines fell from 41.4 before treatment to 6.3 during treatment. Only 6 episodes of infection were due to trimethoprim-resistant bacteria. Results in a small group... | 92,620 | [
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0.1989386,
0.102273... |
Raised maternal serum-alpha-fetoprotein levels and spontaneous fetomaternal transfusion. | Study of blood smears showed that spontaneous fetomaternal transfusions were significantly more common among 42 pregnant women with raised serum-alpha-fetoprotein (AFP) levels than among 45 pregnant women with normal serum-AFP levels. Raised serum-AFP was associated with a spontaneous fetomaternal transfusion of greate... | 92,622 | [
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0.1138952,
0.01485525,
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Cytomegalovirus strain differentiation by DNA restriction analysis. | The heterogeneity of CMV DNA obtained from standard strains and new isolates, including a vaccination strain (Towne 125), was investigated. The cleavage patterns produced by the restriction endonucleases Eco RI and Bam 1 revealed stable strain specificities of CMV. On the other hand, a remarkable homology of sequence-s... | 92,777 | [
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0.7994863,
0.3730475,
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0.04065692,
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Abnormal seminiferous tubule cells associated with choriocarcinoma: immunoperoxidase study. | A case is presented of widely metastatic choriocarinoma, associated with an intratubular proliferation of atypical germ cells in the testis and a minute adult cystic teratoma. Immunoperoxidase study of the intratubular germ cells did not confirm their trophoblastic origin. Intratubular proliferation of undifferentiated... | 92,839 | [
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0.2604806,
0.1886263,
-0.05075705... |
[Leucosis diagnosis in cattle using the Sudan black B staining method on granulocytes and monocytes]. | In the peripheral blood of healthy cattle and cattle suffering from leucosis a positive reaction with Sudan black B was found in neutrophilic and eosinophilic granulocytes: in healthy cattle at an intensity from ++ to ++++, and in cattle suffering from leucosis it was somewhat slighter (++ to +++). This finding can, to... | 92,849 | [
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0.2107578,
0.2394686,
0.3766941,
0.03624982,
-0.14... |
Metastatic neuroblastoma in bone marrow aspirate smears. | The authors observed rosette formation and partially fibrillar, blue-grey, extracellular material in Wright-Giemsa-stained bone marrow aspirate smears in five preparations from three cases of neuroblastoma metastatic to bone marrow. These features are little publicized in the literature and textbooks. These findings in... | 92,888 | [
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0.4509181,
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-0.14162... |
Esophagogastrectomy for carcinoma: current hospital mortality and morbidity rates. | Between January 1, 1970, and March 1, 1979, 153 patients with carcinoma of the esophagus or cardia were seen at the Lahey Clinic; 124 (81%) underwent surgical exploration and 102 (82.3%) were found amendable to resection. This report concerns the 82 patients operated on by the senior author, 72 of whom (87.8%) had surg... | 92,917 | [
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... |
Tuberculosis. Clinical aspects and diagnosis. | The presentation of tuberculosis is variable depending on the severity of the infection, the age of the patient, whether the infection is primary or secondary, and whether the manifestations are due to inhalation of organisms or hematogenous dissemination. A definitive diagnosis is made by culture of the organism; spon... | 92,919 | [
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0.1337985,
-0.03193032... |
Regulation of the kidney xanthine dehydrogenase by glutaminase. | The steady-state concentrations of glutamine, glutamate and ammonia in the kidney cells might regulate the rate of renal xanthine dehydrogenase activity. Both glutamate and glutamine were found to be effective inhibitors of the renal xanthine dehydrogenase activity in vivo. The inhibition by glutamate depends essential... | 92,920 | [
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0.02882422,
-0.0... |
[Effect of S-adenosyl-L-homocysteine of dopamine catabolism]. | 1.--The administration of SAH to rats, at physiologically active dose on the sleep, does not change the urinary level of MD and NM. On the other hand, the excretion of DA and NA decreases. 2.--In the brain, SAH does not modify neither the concentration of NA and NM in hypothalamus and thalamus, nor the concentration of... | 92,923 | [
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0.02851677,
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-0.... |
Biological parameters of the blood in the genetically obese Zucker rat. | A study of the various biological parameters of the blood in the genetically obese Zucker rat, the nonobese Zucker rat, and the Wistar rat has revealed great similarity between the two latter types of animals. On the other hand, in genetically obese Zucker rats as compared with the nonobese ones, (1) the blood mass per... | 92,925 | [
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0.252573,
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-0.... |
Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha 1-antitrypsin and alpha 2-macroglobulin. | A number of soluble proteins contained in human aortic intimal tissue was extracted into buffered saline (pH 7.4) and identified and quantitated by immunoelectrophoresis and immunodiffusion. The proteins included IgA, IgG, IgM, B1C (C3), alpha 1-antitrypsin, alpha 2-macroglobulin, fibrinogen, albumin, LDL, HDL, alpha 1... | 92,993 | [
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-0.02103391,
-0.1150707,
-0.257464,... |
The biologic basis for combined modality treatment of cancer. | Strategies related to cancer should be aimed at optimization of local and regional treatment. Delineation of subsets of patients with high risk for recurrence would have a significant impact, upon which such adjunctive systems of therapeutic management should be evaluated. In disseminated disease, or where the probabil... | 93,031 | [
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0.2276903,
0.4183288,
0.3131386,
0.3394479,
-0.088721... |
Activity staining for glutamate and alanine dehydrogenases in polyacrylamide gels of varying porosity. A study of bovine placental enzyme forms. | A procedure has been developed for characterizing the various molecular forms of placental and liver glutamate dehydrogenases through a combination of activity staining and varying gel pore size in electrophoresis. At a concentration of 2 mg/ml, the bovine liver GDH remained associated in a very high molecular weight f... | 93,046 | [
0.04301571,
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HLA B27 and defects in the T-cell system in Whipple's disease. | The cellular immune system was tested in nine patients with Whipples' disease. Three patients had active disease, and six had been in remission for up to 10 years. Intradermal delayed hypersensitivity reactions to candidin, trichophytin, tuberculin and varidase, T-cell counts as determined by E-rosettes, allogeneic sti... | 93,049 | [
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0.489309,
0.3948821,
0.02386458,
-0.062... |
The histochemistry of complex carbohydrates in the testes of patients of idiopathic male infertility. | In testis tissues from patients with idiopathic male infertility, complex carbohydrates have been studied by means of light microscopic histochemical methods, comparisons being made with the normal testes. In the infertile testes, histochemical reactions for acidic and neutral complex carbohydrates were in general weak... | 93,098 | [
0.3334244,
0.199084,
0.004182836,
0.4123861,
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0... |
Immunocytochemical technique for detection of prolactin (PRL) and growth hormone (GH) in hyperplastic and neoplastic lesions of dog prostate and mammary gland. | An immunocytochemical technique was described to test for immunoreactive prolactin (PRL) and growth hormone (GH) in spontaneous and experimentally induced hyperplastic and neoplastic lesions of the prostate and mammary gland. The dog was used as an animal model. The specificity and validity of the immunocytochemical st... | 93,102 | [
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0.06440035,
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Incubation of 3,4-benzo(s)pyrene with serum fractions: effect on tumor production. | The effect on tumor formation in Swiss mice of incubation of 3,4-Benzo(a)pyrene [B(a)P]either with saline or saline containing serum, gamma-globulin or albumin (form mouse or rabbit) was investigated. A high incidence of sarcomas (80--100%) was obtained in Swiss mice by B(A)P incubated in vitro with rabbit serum, rabbi... | 93,109 | [
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-... |
Influence of an oversulphated heparinoid upon hyaluronate metabolism of the human synovial cell in vivo. | Glycosaminoglycans appear to affect proteoglycan metabolism of fibroblasts, human synovial cells, and chondrocytes under in vitro conditions. The influence of an oversulphated heparinoid (Arteparon) on hyaluronate metabolism of the human synovial lining cell was studied by in vivo experiments on human volunteers. A hig... | 93,148 | [
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0.3554957,
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0.05572207,
... |
Dihydropteridine reductase deficiency diagnosis by assays on peripheral blood-cells. | Human peripheral lymphocytes, granulocytes, and platelets contain the enzyme dihydropteridine reductase. A simple procedure and assay for diagnosing dihydropteridine reductase on peripheral blood is described. In twelve controls the level of enzyme activity in a lymphocyte-platelet preparation was 29.5 +/- 4.8 (SD) nmo... | 93,181 | [
-0.0811431,
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0... |
Brief note. Induction of experimental allergic encephalomyelitis in sheep with purified bovine basic protein and adjuvant. | A large animal model for the induction of experimental allergic encephalomyelitis to study the immunological disease parameters through closed-circuit extracorporeal thoracic duct filtration was successfully produced in two different strains of sheep. This study demonstrates the advantages of using a well-defined antig... | 93,263 | [
0.01412515,
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0.09126811,
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0.2017956,
-0.045688... |
[Thrombocytopenic purpura during heparinotherapy. Two cases (author's transl)]. | In two patients treated by heparin for thrombosis, thrombocytopenia under 10 000/cumm occured accompanied with bleeding cud recurrent thrombosis. The demonstration in the patients' serum of a factor inducing platelet aggregation and serotonin release in the presence of heparin suggests that the thrombocytopenia could b... | 93,273 | [
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0.2589725,
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0.... |
Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex. | Proton NMR studies at 360 MHz establish the binary Fe(II)-bleomycin complex to be paramagnetic with a spectrum covering 70 ppm. Addition of carbon monoxide generates a stable, diamagnetic Fe(II)-bleomycin-CO complex that is a putative structural analog of the "active" Fe(II)-bleomycin-O2 complex. The following six grou... | 93,279 | [
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0.2772771,
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0.1525559,
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Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells. | We have isolated clones of alloreactive T cells by soft agar cloning of primed responder cells contained in serially restimulated, mixed lymphocyte cultures. These clones recognize unique mixed lymphocyte reaction (MLR) stimulating determinants present on (C57B/6 X A/J)F1 (B6A) spleen cells. By assaying the reactivity ... | 93,286 | [
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0.6287795,
0.08094566,
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... |
Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors. | Rabbit antibody against IgE receptors or its F(ab')2 fragments induced an increase of 45Ca uptake into normal mast cells, and this process was accompanied by histamine release. Evidence was obtained that a substantial portion of 45Ca uptake was due to movement of calcium across the cell membrane. Neither 45Ca uptake no... | 93,285 | [
-0.1103189,
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0.111138,
0.06300988,
0.1473112,
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... |
Antigen-induced strain-specific autoantiidiotypic antibodies modulate the immune response to dextran B 512. | Sera from CBA and C57BL mice immunized against dextran B 512 eight or more days earlier contain mainly IgG antibodies that specifically suppress the development of plaque-forming cells against dextran in vitro. Suppression was not caused by antibodies against the alpha 1-6 epitope of dextran to any major extent. Sera f... | 93,287 | [
-0.2303098,
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0.03872815,
0.04071711,
0.3678958,
0.1798554,
-0.1186478... |
HLA-D-restricted antigen activation of sensitized T lymphocytes: studies on the ability of HLA-D/DR-expressing B lymphocytes to substitute for macrophages in antigen activation. | The proliferative response of sensitized human T lymphocytes to purified protein derivative (PPD) and to trinitrophenyl (TNP)-conjugated autologous cells in vitro is restricted by self HLA-D/DR determinants. Here we report that the PPD-specific response is strictly related to the content of phagocytosing cells (macroph... | 93,307 | [
-0.1377104,
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0.1219462,
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0.1469832,
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0.455129,
0.1487267,
0.3353236,
0.04240352,
-0.... |
HLA markers in six Lebanese religious subpopulations. | A total of 315 normal, unrelated individuals from six of the seven principal religious communities of Lebanon have been typed for 26 alleles of the A and B loci. The gene, haplotype frequencies and delta values have been calculated. The HLA gene frequencies for loci A and B reported in this study are shown to cross Mos... | 93,316 | [
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0.03738086,
0.04468441,
0.1337442,
0.582796,
0.1757459,
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0... |
[Soluble Babesia ovis antigen]. | Dissolved antigen of plasma and of erythrocytic cytoplasma was obtained from 4 splenectomized sheep experimentally infected by Babesia ovis. Blood was taken in the stage of acute parasitemia with 23--25% parasite erythrocytes. The antigen was isolated by precipitating the plasma and the erythrocytic cytoplasma three ti... | 93,342 | [
0.06669191,
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0.2742939,
0.2197695,
0.4542781,
0.1339604,
-0.1640619... |
Electron spin resonance studies on phaeomelanins. | ESR spectra of synthetic melanins formed from dopa and from 5-S-cysteinyldopa and of melanins isolated from human melanomas were studied. Alkali-soluble melanin synthesized from cysteinyldopa showed a signal similar to that of insoluble melanin synthesized from dopa, but also a simple fine structure. Trichochromes C an... | 93,370 | [
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0.3176149,
0.1228908,
-0.2026527,
... |
[Combinations of enzyme-histochemical methods for differentiating of fibers types and evaluating the skeletal musculature (author's transl)]. | This paper reports 2 combinations of enzyme-histochemical reactions (NADH tetrazolium oxidoreductase and myosin ATPase after alkaline preincubation, menadione-dependent glycerol-3-phosphate oxidoreductase and myosin ATPase after acid preincubation). One type of skeletal muscle fiber is stained golden-brown and the othe... | 93,384 | [
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0.4280007,
0.8488475,
-0.003522469,
-0.0752... |
Argentophil neuronal perikarya and neurofibrils induced by postmortem trauma and hypertonic perfusates. | Argentophil neuronal perikarya and perikaryal neurofibrils similar to those illustrated in Ramón y Cajal's classical studies have in the present investigation been found to be manifestations of the chromophil neuron. Conclusive evidence of such association was obtained by silver impregnation with the Bodian technique o... | 93,388 | [
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0.1312838,
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0.1998425,
-0.130958... |
Tamoxifen treatment of advanced breast carcinoma. | Sixty postmenopausal patients with microscopically confirmed, progressive mammary carcinoma and local recurrence alone or in combination with distant metastases or with distant metastases only, not previously treated with cytostatics, were given tamoxifen (Nolvadex), 10 mg 3 times daily. The response rate in 37 evaluab... | 93,402 | [
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0.004718018,
0.1801316,
0.2540676,
0.1777557,
0.3030136,
0.3846352,
-0.160167,... |
Inactivation of the slow potassium outward current in crab muscle fibre. | The slow outward current (IK2) recorded in crab muscle fibre using the double sucrose gap method decreases when high and maintained depolarizations are applied. This decrease corresponds to a true inactivation of the potassium conductance rather than to a shift in the reversal potential of the charge carrying ion follo... | 93,440 | [
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0.101979,
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0.2730149,
-0.05751041,
0.171771,... |
[Intravenous perfusion of adrenaline and adaptation to muscular exercise in man]. | Eleven normal subjects underwent epinephrine perfusions (1.9; 6.1; 11.8 ng/min) during a short (20 min) and mild (50% VO2 max) exercise. VO2 was not modified by epinephrine perfusion, while heart rate ventrilation and plasmatic lactate were increased proportionally to epinephrine doses. | 93,447 | [
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0.01949973,
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0.2382167,
0.008921998,
0.08552562,
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0.083023... |
A comparison of the homozygous states for G gamma and G gamma A gamma delta beta thalassaemia. | One Arabic and two Indian patients with thalassaemia intermedia produce only Hb F for the G gamma type. Haemoglobin synthesis studies and genetic analysis indicate that they are homozygous for G gamma delta beta thalassaemia. The findings in these patients and their heterozygous relatives are compared with those in an ... | 93,489 | [
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0.02379958,
0.4461505,
0.1778972,
-0.1644316,
... |
Localization of a gene: the nucleolar organizer. | Nucleolus differentiates around the nucleolus organizer regions of the chromosomes or NORs. In the interphasic nucleoli the fibrillar centers are now considered as the NORs. The purpose of this editorial is to review the experimental data which allowed such identification. Our current concepts regarding this point resu... | 93,494 | [
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... |
Cyclocytidine in the treatment of refractory acute childhood leukemia: a Southwest Oncology Group Phase I-II study. | Thirty-seven children and adolescents with acute leukemia in relapse were treated with cyclocytidine in a cooperative group setting. Only one of the 27 evaluable patients achieved complete remission. A significant decrease (greater than or equal to 20%) in circulating and/or bone marrow leukemia cells occurred in an ad... | 93,513 | [
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0.3553814,
0.3656569,
-0.01595755,
-0.1719... |
Cross-reactions between serum proteins and water soluble liver tissue antigens of the nine-banded armadillo (Dasypus novemcinctus Linn.) and man. | Cross-reactions between serum proteins and water soluble liver antigens of the nine-banded armadillo (Dasypus novemcinctus Linn.) and man were studied by crossed immunoelectrophoresis (CIE). Armadillo serum tested with rabbit antiserum against human serum proteins gave twelve components in CIE. Nine of these cross-reac... | 93,527 | [
-0.05724659,
-0.08046483,
0.04655486,
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0.1088771,
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0.3914095,
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-0.2290421,
... |
Effects of gibberellic acid and of tunicamycin on glycosyl-transferase activities and on alpha-amylase secretion in barley. | A crude membrane fraction was prepared from isolated aleurone layers, the secretory tissue of barley grains. The layers were pre-incubated in the presence or absence of the phytohormone gibberellic acid. The membranes catalyzed the transfer of [14C]mannose from GDP-[14C]mannose and of N-[14C]acetylglucosamine from UDP-... | 93,536 | [
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0.03208009,
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-... |
Carcinoembryonic proteins in gastric carcinoma metastatic to the liver. | Two cases of liver metastases from gastric carcinoma are described in which the simultaneous occurrences of alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and carcinoplacental alkaline phosphatase (CPALP) were demonstrated in the sera and tumor tissues. AFP was detected not only in the tumor tissues but also i... | 93,560 | [
0.02115151,
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0.... |
Antigenic heterogeneity of the non-serogroup antigen structure of Neisseria gonorrhoeae lipopolysaccharides. | Studies of the antigenic structure of the polysaccharide component of gonococcal lipopolysaccaride (LPS) indicated that the non-serogroup antigen structure is antigenically heterogeneous. Immunodiffusion studies of Gc4 strain 8551 indicated that in addition to the Gc serogroup determinent, this polysaccharide contains ... | 93,575 | [
0.1039915,
0.4157307,
0.117904,
0.01185773,
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0.2141774,
0.07191259,
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... |
Rauscher leukemia virus-induced tumor antigens: complete separation from gp70, p30 and H-2. | The possibility that some or all of the viral proteins, gp70, p30, and the histocompatibility antigen, H-2, function as the tumor-specific transplantation antigen (TSTA) of the R-MuLV-induced leukemia, RBL-5, and also in the secondary in vitro induction of cytotoxic T lymphocytes (CTL), was investigated. The antigen wa... | 93,583 | [
-0.05908645,
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0.4149276,
0.1722921,
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0... |
Abortive expression of the Epstein-Barr virus (EBV) cycle in a variety of EBV DNA-containing cell lines, as reflected by nucleic acid hybridization in situ. | A variety of Epstein-Barr virus (EBV) DNA-containing cell lines have been tested for the expression of the EBV-associated antigens EBNA (nuclear antigen), EA (early antigen), and VCA (viral capsid antigen), and for the presence of cells containing disproportionate amounts of EBV DNA. The antigen tests utilized immunofl... | 93,584 | [
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0.196092,
0.325012,
0.03090419,
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... |
The effect of mazindol on metabolic and regulatory changes in obese women during weight reduction. | The effect of mazindol (1 mg/day) on some metabolic and regulatory values was investigated in ten adult obese women and compared with the same number of controls during weight reduction in hospital (a five-times repeated cycle of 5 days complete starvation and 3 days on a 500 kcal(2.1MJ/day diet.) Mazindol caused a ris... | 93,588 | [
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0.5062119,
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0.276991,
-0.1640132... |
Ruthenium red as a stain for electron microscopy. Some new aspects of its application and mode of action. | Commercial ruthenium red has been tested for its purity by spectrophotometry. Impurities detected by this method could be abolished by nitric acid-precipitation of ruthenium brown. This substance has no effect on cell surface staining and converts almost completely to ruthenium red under the conditions used in electron... | 93,592 | [
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0.02832575,
... |
Susceptibility to butirosin and neomycin B in Bacillus circulans, the butirosin-producing organism. | Butirosin, an aminoglycoside antibiotic, is produced by Bacillus circulans B-3312. Experiments using recombined ribosomal and supernatant fractions from this strain and from B. megaterium KM have shown that the ribosome of both are sensitive to butirosin. The aminoglycoside 3'-phosphotransferase present in B. circulans... | 93,616 | [
0.1731572,
0.05856754,
-0.1510683,
0.1616309,
-0.04277336,
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0.01521517,
0.1112425,
0.1339469,
-0.001325236,
0.1672785,
0.01747509,
0.1082112,
0.1931832,
-0.4458068,
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-0.04681487,
0.09009063,
0.1981198,
0.3466095,
0.1163733,
-0.04352659,
... |
Charcot-Marie-Tooth disease associated with retinal pigment dystrophy and protanopia. Neurological, ophthalmological and genetic study of a family. | Neurological, ophthalmological and genetic investigations were performed on a family, a member of which presented with a rare association of tapeto-retinal degeneration, protanopia and Charcot-Marie-Tooth disease (CMT), and asked for genetic counseling. The neurological enquiry was completed by measurement of motor ner... | 93,622 | [
0.1652282,
-0.3639401,
-0.001550748,
-0.2205352,
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-0.2655998,
0.04347369,
0.1178925,
0.05531448,
-0.00716368,
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-0.5064062,
-0.1087964,
-0.1116193,
-0.1437044,
-0.09068146,
0.1548795,
-0.03... |
[Changes in the physiologic properties of a chemostat culture of Propionibacterium shermanii during growth limitation by a deficiency of sodium lactate]. | A chemostat curve has been constructed for changes in the Propionibacterium shermanii population density with an increase in the flow rate of the medium from 0.04 to 0.55 h-1 upon limitation of the growth with sodium lactate deficiency. The curve differs from the classic chemostat curve described with the Monod equatio... | 93,687 | [
-0.2241928,
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0.00604956,
0.1176101,
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0.2542584,
0.2398338,
-0.04427576,
-0.08031899,
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0.1124917,
0.1307755,
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-0.2724149,
0.2913499,
0.1087966,
0.3110708,
0.4925277,
0.007823407,
0.05253569,
... |
Effects of a chromatin low molecular weight peptidic fraction on differentiation markers and virus production in Friend leukemia cells. | Low molecular weight chromatin peptides exert a dose-dependent inhibition of Dimethylsulfoxide (DMSO)-induced erythroid differentiation of murine Friend Leukemia Cells (FLC). This effect correlates with the degree of purification of the peptide fractions. Crot analysis of globin mRNA amounts in DMSO-treated FLC given t... | 93,693 | [
0.04083356,
0.2019487,
0.008374834,
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0.1158179,
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0.1824204,
0.1193921,
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0.4489478,
0.2160612,
-0.04736093,
-0.3246787,
-0.1... |
Location of bladder preganglionic neurons within the sacral parasympathetic nucleus of the cat. | Sacral parasympathetic preganglionic neurons innervating the urinary bladder were labelled by applying horseradish peroxidase (HRP) to branches of the pelvic nerve at the neck of the bladder. Bladder preganglionic cells were located primarily in the intermediolateral grey matter of sacral cord segments 1, 2 and 3 and e... | 93,725 | [
0.2084073,
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0.1514081,
0.1338093,
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0.1964046,
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0.5316621,
0.3804253,
-0.4822765,
0.005314074,
0.4088396,
0.2022273... |
16, 16 dimethyl prostaglandin E2 reduces histamine release from the stomach and protects the gastric mucosal barrier altered by ethanol in neutral solution. | Damage to the gastric mucosal barrier results in histamine release from intramucosal stores. Previous reports have shown that 16, 16 dimethyl prostaglandin E2 (dm PGE2) protects the stomach from injury by various damaging agents in either acidic or neutral solution. Furthermore histamine released in response to a damag... | 93,761 | [
-0.3628701,
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0.3014539,
0.006306934,
0.04252685,
-0.06310377,
0.1598132,
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0.2489473,
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-0.04025895,
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0.06608353,
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0.1908533,
-0.2457051,
0.028224,
-0.0252302,
0.04161616,
0.09277119... |
Cytologic investigations in Chlamydia infection. | Chlamydia is an extremely common genital infection. It can cause serious disseminated disease and can infect the neonate and the sexual partner. Morphologically, Chlamydia infection was identified in routine Fast smears obtained from 160 women. Chlamydia infection manifests as intracytoplasmic coccoid and inclusion bod... | 93,839 | [
-0.05025855,
0.1426686,
-0.05646985,
0.09085061,
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0.04518761,
0.1013398,
0.223192,
0.3382077,
0.3099468,
-0.08182869,
0.3038283,
0.0164942,
-0.2792183,
-0.4513018,
-0.06920348,
-0.155385,
-0.1114717,
0.475111,
0.1913577,
0.0296816,
0.... |
Intra-operative frozen section technique for pituitary adenomas. | Orange G-hematoxylin stains performed on frozen sections from the sella turcica had a diagnostic accuracy of over 90% when compared to permanent sections on the same tissue. This technique allows the pathologist to make an intra-operative contribution to the establishment of tumor margins in the selective removal of pi... | 93,851 | [
-0.01390766,
-0.04529054,
-0.2331202,
-0.1994341,
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-0.09041026,
-0.2040756,
0.1513463,
0.06125133,
0.1967132,
0.4340224,
0.1032758,
-0.34639,
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-0.1463999,
0.01605624,
-0.09853381,
-0.05656151,
0.1845319,
0.032506,
-0.1714463,
... |
Role of serotoninergic and adrenergic mechanisms in the action of prominal. | The aim of this work was determination of the interrelations between the metabolism of biogenic amines in the brain and the action of Prominal. The power of the anticonvulsive action of Prominal was decreased by p-chlorphenylalanine (PCPA). The influence of the tested anticonvulsant on the levels of noradrenaline (NA),... | 93,847 | [
-0.01121746,
-0.157157,
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-0.2651446,
-0.08348466,
-0.1303592,
-0.4412678,
-0.182858,
-0.1044274,
0.09516329,
-0.1917547,
0.002507847,
0.5690871,
0.3188159,
-0.4652454,
0.228894,
-0.2544322,
0.09933474,
-0.1642368,
0.4889731,
-0.1399027,
0.145012,
-0.2333832,
-... |
Characterization of clones derived from an attenuated strain of Rauscher murine leukaemia virus. | With a view to defining its subpopulations, an attenuated strain of Rauscher leukaemia virus, which comprises a majority of fragile virions, was closed by end-point dilution. The presence in the obtained clones of markers (analyzed by radioimmunoassay and isoelectric focusing) associated with Rauscher virus, together w... | 93,858 | [
-0.2808984,
-0.1168447,
-0.2337729,
-0.1645528,
0.1482733,
-0.1929616,
-0.1262418,
0.08414828,
0.1954648,
-0.06776831,
-0.1183029,
-0.1227362,
-0.08010284,
0.1238939,
-0.1248311,
-0.09516989,
-0.4418457,
-0.09336983,
0.1661316,
0.2031717,
0.2327998,
-0.0802072,
-0.147086,... |
Triggering of autolytic cell wall degradation in Escherichia coli by beta-lactam antibiotics. | A biochemical method was developed to quantitatively compare the effectiveness of beta-lactams in triggering murein degradation (autolysin activity) in Escherichia coli. Bacteria prelabeled in their cell walls with radioactive diaminopimelic acid in growth medium were exposed for 10 min to the antibiotics at the approp... | 93,877 | [
0.04351413,
-0.2058382,
-0.2053416,
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0.150862,
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0.02022928,
-0.02074068,
0.3667897,
0.03196556,
0.03416458,
0.2902404,
-0.09729838,
0.2006277,
-0.2810396,
0.2502777,
-0.3781492,
-0.02106941,
-0.3462985,
0.3821563,
0.7319052,
0.3898346,
0.01931365,
... |
Studies on the cholinesterase forms present in the ascitic fluid of Ehrlich tumour. | Cholinesterase activity was detected in the ascitic fluid of Ehrlich tumour and studied in a comparative manner in relation to that found in mice plasma. Enzymes from both sources were characterized with respect to optimum pH, substrate concentration and quinidine inhibition. After gel filtration by Sephadex G-200 and ... | 93,888 | [
-0.1479767,
0.09167075,
-0.3124038,
-0.2750145,
-0.04489153,
-0.2204875,
-0.005817455,
-0.1455538,
-0.07571348,
0.2999259,
-0.05929023,
0.1853503,
0.06719188,
0.1765504,
-0.4421194,
0.1834862,
-0.2024015,
-0.02937856,
0.005956641,
0.1383931,
0.2482904,
-0.1480212,
0.00442... |
[Deoxyribonucleic acids from Pasteurella multocida and Pasteurella haemolytica]. | Pasteurella multocida and P. haemolytica strains contain between 1.5 and three per cent phosphorus, between nine and 14 per cent nitrogen, between two and four per cent DNA, and between five and 18 per cent RNA, the precise figures depending on culturing conditions. High-molecular DNA may be isolated by means of bacter... | 93,955 | [
-0.3566115,
0.01301217,
0.1269996,
-0.06449734,
0.003402799,
-0.08281944,
-0.08964284,
0.07583293,
0.03698727,
0.0546857,
0.1210019,
-0.1892599,
0.001854538,
-0.00057186,
-0.7166398,
-0.1703981,
0.08362883,
0.05873843,
0.0362508,
0.4666414,
0.8061885,
0.1457122,
-0.202175... |
Autoradiographic thymidine-3H activity after successive steps of the Feulgen reaction. | Autoradiographs were prepared of sections of the ovary of Dytiscus marginalis labelled with thymidine-3H after each successive step of the Feulgen reaction and after treatment with each separate component of the Schiff's reagent. Results of grain counts over ovarian nurse cells showed that losses of thymidine-3H activi... | 93,963 | [
0.09698252,
-0.1321376,
-0.2392719,
0.1979222,
0.4099371,
-0.2007248,
0.0583916,
-0.2495048,
0.1693878,
0.05494789,
-0.01392912,
-0.1263248,
-0.01116744,
-0.07775003,
-0.0788889,
-0.2494408,
-0.7885948,
0.3546147,
-0.08115081,
0.240075,
0.2340461,
0.1518445,
-0.3259912,
... |
Diagnosis and staging of prostatic cancer by transrectal ultrasonography. A preliminary study. | Sixty men (7 normal, 53 with prostatic disease) underwent transrectal ultrasonic scanning of their prostates in order to assess the technique and evaluate its reliability in the detection and staging of prostatic cancer. The prostatic capsule was clearly seen in 58 men; non-integrity of the capsule occurred only in tho... | 93,975 | [
-0.3482595,
0.1234334,
0.03886312,
-0.3401951,
-0.0259671,
-0.3764454,
-0.0136426,
0.055965,
0.2030843,
-0.1169718,
0.1717154,
-0.06934844,
-0.1295416,
-0.2239553,
-0.5132722,
-0.01298021,
-0.1853075,
0.2793883,
-0.1611203,
-0.5264874,
0.4788728,
-0.02568352,
-0.006206315... |
Identification of a silver binding protein associated with the cytological silver staining of actively transcribing nucleolar regions. | Nucleoli isolated from Novikoff hepatoma cells were stained with AgNO3 to demonstrate the typical staining of active ribosomal cistrons. Pre-treatment of the nucleoli with 80 mM Tris-HCl (pH 7.5) -- 2.0 M NaCl did not interfere with silver staining. Treatment of the nucleoli with 80 mM Tris-HCl (pH 7.5) -- 0.15 M NaCl ... | 93,980 | [
0.007398728,
0.09679151,
-0.2262755,
-0.01457733,
0.2175212,
0.05381525,
-0.3355495,
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0.2936646,
0.1635496,
0.06316005,
-0.1226811,
0.3309458,
-0.43397,
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0.0399557,
-0.3768369,
0.06528049,
0.08563384,
0.09710784,
0.2029415,
0.1345535,
0.05578181,
0... |
Microscopic visualization of axon carbohydrates. | Localization of glycoproteins and mucopolysaccharides in Central and Perypheral Nervous System axons of several mammals is studied by means of histochemical techniques. In some system of fibers of the Central Nervous System the inside of the axon appears PAS positive. However, Concanavalin A binding sites were not obse... | 94,078 | [
0.1730833,
-0.3781272,
-0.1723318,
0.2049938,
-0.003963479,
-0.4099279,
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0.01283165,
-0.4427913,
0.2072909,
-0.1254384,
0.01588955,
0.1016846,
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0.03121334,
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-0.1579062,
0.001876342,
-0.1072735,
-0.2288334,
0.1441868,
0.3983976,
-0.1057578,... |
Effects of tamoxifen on the binding and metabolism of testosterone by human prostatic tissue and plasma in vitro. | The in-vitro metabolism of testosterone in benign and malignant prostatic tissue was examined and distinct quantitative differences between the two types of specimens were observed. The major metabolite of testosterone in the hyperplastic prostate was 5 alpha-dihydrotestosterone and a high 3 alpha(beta)-hydroxysteroid ... | 94,084 | [
-0.1332544,
0.2343368,
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-0.2271008,
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0.1481525,
0.3935691,
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0.08288943,
0.1208343,
0.4546225,
-0.0639061,
0.00001623887,
-0.8283193,
0.01709893,
-0.1199853,
-0.04092151,
0.1285221,
0.2530878,
0.4257387,
0.5252977,
-0.1441279,
... |
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