title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Type 3 diabetes is sporadic Alzheimer׳s disease: mini-review. | Alzheimer׳s disease (AD) is the most common cause of dementia in North America. Growing evidence supports the concept that AD is a metabolic disease mediated by impairments in brain insulin responsiveness, glucose utilization, and energy metabolism, which lead to increased oxidative stress, inflammation, and worsening ... | 25,088,942 | [
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Hybrid inverse opals for regulating cell adhesion and orientation. | Cell adhesion and alignment are two important considerations in tissue engineering applications as they can regulate the subsequent cell proliferation activity and differentiation program. Although many effects have been applied to regulate the adhesion or alignment of cells by using physical and chemical methods, it i... | 25,088,946 | [
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High quality RNA in semen and sperm: isolation, analysis and potential application in clinical testing. | Male infertility is a complex health condition. To our knowledge there are no molecular biomarkers of male infertility. Sperm RNA is a potential biomarker for detecting sperm abnormalities and viability at infertility clinics. However, RNA use is hindered by its inconsistent quantity, quality, multiple cell types in se... | 25,088,949 | [
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Construction of three-dimensional liver tissue models by cell accumulation technique and maintaining their metabolic functions for long-term culture without medium change. | Three-dimensional (3D) hepatocyte cultures have attracted much attention to obtain high biological functions of hepatocyte for pharmaceutical drug assessment. However, maintaining the high functions for over one month is still a key challenge although many approaches have been reported. In this study, we demonstrate fo... | 25,088,964 | [
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Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature. | Endothelial dysfunction is characterized by impaired endothelium-dependent vasodilatation and is an independent predictor of adverse cardiovascular consequences. The ease with which endothelial function can be assessed has led to it becoming a useful marker of cardiovascular diseases in research studies. Obstructive sl... | 25,088,969 | [
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Prediction of activity type in preschool children using machine learning techniques. | Recent research has shown that machine learning techniques can accurately predict activity classes from accelerometer data in adolescents and adults. The purpose of this study is to develop and test machine learning models for predicting activity type in preschool-aged children. Participants completed 12 standardised a... | 25,088,983 | [
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Case study on possible falling patterns of a fatal fall from stairs. | Considering a fatal case of an aged individual, who died due to falling down stairs, the cause of the fatal fall was investigated through experiments. A witness, who was with the victim, when the fatal accident occurred, stated that the aged individual had miss-footed, lost balance at the top of the stairs, and fell ac... | 25,088,990 | [
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Interplay between myogenic pacemakers and enteric neurons determine distinct motor patterns in the rat colon. | Waxing and waning of slow waves amplitude has been recently associated with a segmentation motor pattern in the murine small intestine. The 'wax and wane' phenomenon in this area of the gastrointestinal tract seems to be the result of modulation of slow waves by a second pacemaker of a lower frequency displayed by the ... | 25,088,991 | [
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Association of PS gene polymorphism and soluble P-selectin levels in atrial fibrillation thromboembolism population in Xinjiang. | To investigate the association between the polymorphism of P choose element (p. selectin, PS) and soluble P-selectin levels in atrial fibrillation (AF) thromboembolism in Han and Uigur population of Xinjiang. Using ELISA method determination of plasma level of sPs. The frequency distributions of SNP sP-selectin gene pr... | 25,089,002 | [
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Improving structural medical process comparison by exploiting domain knowledge and mined information. | Process model comparison and similar process retrieval is a key issue to be addressed in many real-world situations, and a particularly relevant one in medical applications, where similarity quantification can be exploited to accomplish goals such as conformance checking, local process adaptation analysis, and hospital... | 25,089,017 | [
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Paradoxical reaction to antituberculosis therapy in a patient with lupus vulgaris. | Patients receiving treatment for tuberculosis may experience an unexpected deterioration of their disease; this is known as a paradoxical reaction. We present the case of a 59-year-old man with lupus vulgaris who experienced a paradoxical deterioration of cutaneous lesions after starting antituberculosis therapy. The r... | 25,089,032 | [
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[Prenatal diagnosis of a giant cystic lymphangioma in the axillothoracic wall]. | Cystic lymphangiomas are benign malformative tumors of the lymphatic vessels, rare but potentially serious and usually located in the cervical region. The diagnosis is usually easy, but the treatment is sometimes difficult because of their location and extension into the surrounding tissue. We report a case of giant cy... | 25,089,042 | [
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Evolution and the Growth Process: Natural Selection of Entrepreneurial Traits. | This research suggests that a Darwinian evolution of entrepreneurial spirit played a significant role in the process of economic development and the dynamics of inequality within and across societies. The study argues that entrepreneurial spirit evolved non-monotonically in the course of human history. In early stages ... | 25,089,059 | [
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Input of easily available organic C and N stimulates microbial decomposition of soil organic matter in arctic permafrost soil. | Rising temperatures in the Arctic can affect soil organic matter (SOM) decomposition directly and indirectly, by increasing plant primary production and thus the allocation of plant-derived organic compounds into the soil. Such compounds, for example root exudates or decaying fine roots, are easily available for microo... | 25,089,062 | [
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The dynamics of city formation. | This paper examines city formation in a country whose urban population is growing steadily over time, with new cities required to accommodate this growth. In contrast to most of the literature there is immobility of housing and urban infrastructure, and investment in these assets is taken on the basis of forward-lookin... | 25,089,087 | [
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Advanced Extramammary Paget's Disease of the Groin, Penis, and Scrotum. | Extramammary Paget's disease (EMPD) is a rare intraepithelial malignancy arising in areas rich in apocrine glands, such as the perineum, vulva, axilla, scrotum, and penis. We describe the case of a man in his 50s who initially presented with a small eczematous lesion on his right groin, treated with topical ointments f... | 25,089,091 | [
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Factors associated with delayed time to adjuvant chemotherapy in stage iii colon cancer. | Adjuvant chemotherapy started more than 56 days after colon cancer resection has been associated with lesser overall survival among patients with stage iii colon cancer. The objective of the present population-based study was to determine, in referred patients with resected stage iii colon cancer, factors associated wi... | 25,089,100 | [
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Increasing Confidence of LC-MS Identifications by Utilizing Ion Mobility Spectrometry. | Ion mobility spectrometry in conjunction with liquid chromatography separations and mass spectrometry offers a range of new possibilities for analyzing complex biological samples. To fully utilize the information obtained from these three measurement dimensions, informatics tools based on the accurate mass and time tag... | 25,089,116 | [
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Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns. | Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial cells (IPE) ... | 25,089,120 | [
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A case of unruptured aneurysm of the right sinus of valsalva with right ventricular outflow obstruction. | A 66-year-old man presented with exertional dyspnea. He was found to have an unruptured aneurysm of the right sinus of Valsalva causing significant right ventricular outflow obstruction. This aneurysm was diagnosed by transthoracic two-dimensional echocardiography, transthoracic three-dimensional echocardiography, tran... | 25,089,142 | [
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Serum proBDNF/BDNF and response to fluvoxamine in drug-naïve first-episode major depressive disorder patients. | We investigated the association between serum proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), and response to fluvoxamine in patients with major depressive disorder (MDD) using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR): physically healthy and ... | 25,089,150 | [
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Strangulated or incarcerated spontaneous lumbar hernia as exceptional cause of intestinal obstruction: case report and review of the literature. | Lumbar hernias are rare conditions and about 300 cases have been reported since the first description by Barbette in 1672. Therefore strangulation or incarceration are also exceptionally encountered. We present a 62 -year-old-man who had strangulated left lumbar hernia and consequent mechanical small-bowel obstruction,... | 25,089,151 | [
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Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder. | Human exposure to cadmium has adverse effects on the nervous system. Utilizing data from 110 age- and sex-matched case-control pairs (220 children) ages 2-8 years in Kingston, Jamaica, we compared the 75<supth</sup percentile of blood cadmium concentrations in children with and without Autism Spectrum Disorder (ASD). I... | 25,089,152 | [
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Follow-up in melanoma patients. | Due to lack of evidence from prospective clinical trials, the diagnostic procedures, their frequency, as well as the length of the follow-up period in cutaneous melanoma patients should be based on the individual risk of disease recurrence, which is strongly dependent on the stage of disease at the time of diagnosis. I... | 25,089,158 | [
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Effect of Solution Composition on the Energy Production by Capacitive Mixing in Membrane-Electrode Assembly. | In this work, we consider the extent to which the presence of multivalent ions in solution modifies the equilibrium and dynamics of the energy production in a capacitive cell built with ion-exchange membranes in contact with high surface area electrodes. The cell potential in open circuit (OCV) is controlled by the dif... | 25,089,164 | [
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Perspectives on the Growth of High Edge Density Carbon Nanostructures: Transitions from Vertically Oriented Graphene Nanosheets to Graphenated Carbon Nanotubes. | Insights into the growth of high edge density carbon nanostructures were achieved by a systematic parametric study of plasma-enhanced chemical vapor deposition (PECVD). Such structures are important for electrode performance in a variety of applications such as supercapacitors, neural stimulation, and electrocatalysis.... | 25,089,165 | [
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Instrument-free nucleic acid amplification assays for global health settings. | Many infectious diseases that affect global health are most accurately diagnosed through nucleic acid amplification and detection. However, existing nucleic acid amplification tests are too expensive and complex for most low-resource settings. The small numbers of centralized laboratories that exist in developing count... | 25,089,171 | [
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Consistent 4D Brain Extraction of Serial Brain MR Images. | Accurate and consistent skull stripping of serial brain MR images is of great importance in longitudinal studies that aim to detect subtle brain morphological changes. To avoid inconsistency and the potential bias introduced by independently performing skull-stripping for each time-point image, we propose an effective ... | 25,089,172 | [
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0.4458676,
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Nitrite and nitrate levels of gingival crevicular fluid and saliva in subjects with gingivitis and chronic periodontitis. | Nitrosative stress plays an essential role in the pathogenesis of periodontal disease. The aim of this study is to analyze the gingival crevicular fluid and saliva nitrite and nitrate levels in periodontally healthy and diseased sites. A total of 60 individuals including, 20 chronic periodontitis and 20 gingivitis pati... | 25,089,177 | [
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Treatment matching for obesity: identifying mediators of psychosocial and behavioral intervention components. | In light of the limited long-term success of obesity treatments, it is tempting to consider the elusive goal of 'treatment matching', in which characteristics of individuals are optimally matched to targeted treatments to improve success. Previous frameworks for treatment matching in obesity have primarily focused on b... | 25,089,190 | [
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Sedentary behavior: target for change, challenge to assess. | Sedentary behavior is not a new topic, but trying to examine the direct links between sedentary behavior and health outcomes, independent of time spent in moderate- and vigorous-intensity physical activity, is a relatively new addition to the relationships between physical activity and health. Defining sedentary behavi... | 25,089,191 | [
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Metabolic heterogeneity of obesity: role of adipose tissue. | Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogene... | 25,089,194 | [
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Metastability in plyometric training on unstable surfaces: a pilot study. | In the past, plyometric training (PT) has been predominantly performed on stable surfaces. The purpose of this pilot study was to examine effects of a 7-week lower body PT on stable vs. unstable surfaces. This type of exercise condition may be denoted as metastable equilibrium. Thirty-three physically active male sport... | 25,089,202 | [
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Mouse Models of 22q11.2-Associated Autism Spectrum Disorder. | Copy number variation (CNV) of human chromosome 22q11.2 is associated with an elevated rate of autism spectrum disorder (ASD) and represents one of syndromic ASDs with rare genetic variants. However, the precise genetic basis of this association remains unclear due to its relatively large hemizygous and duplication reg... | 25,089,229 | [
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Long-term outcome of early stage prostate cancer treated with brachytherapy analysis after a mean follow-up of 7 years. | To investigate the long-term efficacy of (125)I brachytherapy in early-stage prostate cancer and to identify correlating factors. This study included 117 cases of early stage prostate cancer. The patients ranged in age from 51 to 84 years, with a mean of 73 years. The features of the study population were as follows: t... | 25,089,248 | [
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Successive exposure to moderate hypoxia does not affect glucose metabolism and substrate oxidation in young healthy men. | Exposure to hypoxia has been suggested to acutely alter glucose regulation. However, the effects of successive exposure to moderate hypoxia on postprandial glucose regulation and substrate oxidation pattern after multiple meals have not been elucidated. We examined the effects of successive exposure to moderate hypoxia... | 25,089,253 | [
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Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes. | As energy producers, mitochondria play a pivotal role in multiple cellular processes. Although several lines of evidence suggest that differential expression of mitochondrial respiratory complexes (MRCs) has a significant impact on mitochondrial function, the role of integrated MRCs in the whole coexpression network ha... | 25,089,262 | [
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In silico investigation of potential pyruvate kinase M2 regulators from traditional Chinese medicine against cancers. | A recent research in cancer research demonstrates that tumor-specific pyruvate kinase M2 (PKM2) plays an important role in chromosome segregation and mitosis progression of tumor cells. To improve the drug development of TCM compounds, we aim to identify potent TCM compounds as lead compounds of PKM2 regulators. PONDR-... | 25,089,263 | [
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Eradication of multidrug-resistant <i>A. baumannii</i> in burn wounds by antiseptic pulsed electric field. | Emerging bacterial resistance to multiple drugs is an increasing problem in burn wound management. New non-pharmacologic interventions are needed for burn wound disinfection. Here we report on a novel physical method for disinfection: antiseptic pulsed electric field (PEF) applied externally to the infected burns. In a... | 25,089,285 | [
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Estimation of cyclic interstory drift capacity of steel framed structures and future applications for seismic design. | Several studies have been devoted to calibrate damage indices for steel and reinforced concrete members with the purpose of overcoming some of the shortcomings of the parameters currently used during seismic design. Nevertheless, there is a challenge to study and calibrate the use of such indices for the practical stru... | 25,089,288 | [
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Side chain engineering of n-type conjugated polymer enhances photocurrent and efficiency of all-polymer solar cells. | Side chain engineering of an n-type polymer provides a means of maintaining solubility while increasing crystallinity and electron mobility, leading to enhanced photocurrent. Bulk heterojunction solar cells composed of a side chain engineered copolymer (PNDIS-30BO) as acceptor and PSEHTT as donor give 10.4 mA cm(-2) ph... | 25,089,300 | [
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Developmental dissociation in the neural responses to simple multiplication and subtraction problems. | Mastering single-digit arithmetic during school years is commonly thought to depend upon an increasing reliance on verbally memorized facts. An alternative model, however, posits that fluency in single-digit arithmetic might also be achieved via the increasing use of efficient calculation procedures. To test between th... | 25,089,323 | [
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[Results of measuring neutrons doses and energy spectra inside Russian segment of the International Space Station in experiment "Matryoshka-R" using bubble detectors during the ISS-24-34 missions]. | The paper presents the results of calculating the equivalent dose from and energy spectrum of neutrons in the right-hand crewquarters in module Zvezda of the ISS Russian segment. Dose measurements were made in the period between July, 2010 and November, 2012 (ISS Missions 24-34) by research equipment including the bubb... | 25,089,327 | [
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Synthesis of novel gold mesoflowers as SERS tags for immunoassay with improved sensitivity. | A new class of flowerlike gold mesostructure in high yield is successfully synthesized through a facile one-step route using ascorbic acid as a reducing agent of gold salt with cetyltrimethylammonium chloride (CTAC) as surfactant. The as-prepared Au particles have spherical profiles with an averaged diameter of 770 ± 5... | 25,089,331 | [
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University students' attitudes toward same-sex parenting and gay and lesbian rights in Portugal. | The purpose of this study was to explore university students' attitudes toward same-sex parenting and toward gay and lesbian rights. A total of 292 participants, aged between 18 and 27 (M = 21) responded to a questionnaire measuring attitudes toward parenting by gay men and lesbians, gay and lesbian rights, and beliefs... | 25,089,332 | [
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The moderating effects of school climate on bullying prevention efforts. | Bullying prevention efforts have yielded mixed effects over the last 20 years. Program effectiveness is driven by a number of factors (e.g., program elements and implementation), but there remains a dearth of understanding regarding the role of school climate on the impact of bullying prevention programs. This gap is s... | 25,089,333 | [
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Quorum sensing in Bacillus thuringiensis is required for completion of a full infectious cycle in the insect. | Bacterial cell-cell communication or quorum sensing (QS) is a biological process commonly described as allowing bacteria belonging to a same pherotype to coordinate gene expression to cell density. In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors regulated by secreted and re-impor... | 25,089,349 | [
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Total fat consumption and pancreatic cancer risk: a meta-analysis of epidemiologic studies. | Fat consumption has been hypothesized to influence pancreatic cancer risk, but the results of epidemiologic studies have been controversial. We conducted a systematic review and meta-analysis of case-control and cohort studies to investigate this issue. Relevant published studies were identified by searching MEDLINE (P... | 25,089,377 | [
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Thermal properties of borate crystals for high power optical parametric chirped-pulse amplification. | The potential of borate crystals, BBO, LBO and BiBO, for high average power scaling of optical parametric chirped-pulse amplifiers is investigated. Up-to-date measurements of the absorption coefficients at 515 nm and the thermal conductivities are presented. The measured absorption coefficients are a factor of 10-100 l... | 25,089,381 | [
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Carrier-envelope phase effects on the spatial coherence of high-order harmonics. | In this work, we report the Carrier-Envelope Phase Effects on the Spatial Coherence of High-order Harmonics driven by phase-stabilized few-cycle mid-infrared laser pulses. The degree of coherence varies with carrier-envelope phase periodically with a period of π. At the same time, as the harmonic orders increase, the e... | 25,089,385 | [
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Goos-Hänchen-like shift of three-level matter wave incident on Raman beams. | When a three-level atomic wavepacket is obliquely incident on a "medium slab" consisting of two far-detuned laser beams, there exists lateral shift between reflection and incident points at the surface of a "medium slab", analogous to optical Goos-Hänchen effect. We evaluate lateral shifts for reflected and transmitted... | 25,089,388 | [
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Electrically tunable high Q-factor micro-ring resonator based on blue phase liquid crystal cladding. | This work demonstrates an electrically tunable silicon nitride (SiN) micro-ring resonator with polymer-stabilized blue phase liquid crystals (PSBPLCs) cladding. An external vertical electric field is applied to modulate the refractive index of the PSBPLCs by exploiting its fast-response Kerr effect-induced birefringenc... | 25,089,398 | [
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Potential of multi-photon upconversion emissions for fluorescence diffuse optical imaging. | The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversi... | 25,089,399 | [
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Temperature dependence of the radiative recombination time in ZnO nanorods under an external magnetic field of 6 T. | The Temperature dependence of the exciton radiative decay time in ZnO nanorods has been investigated, which is associated with the density of states for the intra-relaxation of thermally excited excitons. The photoluminescence decay time was calibrated by using the photoluminescence intensity in order to obtain the rad... | 25,089,415 | [
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Measurement of energy contrast of amplified ultrashort pulses using cross-polarized wave generation and spectral interferometry. | We present a method using spectral interferometry (SI) to characterize a pulse in the presence of an incoherent background such as amplified spontaneous emission (ASE). The output of a regenerative amplifier is interfered with a copy of the pulse that has been converted using third-order cross-polarized wave generation... | 25,089,416 | [
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Boundary-artifact-free phase retrieval with the transport of intensity equation II: applications to microlens characterization. | Boundary conditions play a crucial role in the solution of the transport of intensity equation (TIE). If not appropriately handled, they can create significant boundary artifacts across the reconstruction result. In a previous paper [Opt. Express 22, 9220 (2014)], we presented a new boundary-artifact-free TIE phase ret... | 25,089,451 | [
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Digital multi-channel stabilization of four-mode phase-sensitive parametric multicasting. | Stable four-mode phase-sensitive (4MPS) process was investigated as a means to enhance two-pump driven parametric multicasting conversion efficiency (CE) and signal to noise ratio (SNR). Instability of multi-beam, phase sensitive (PS) device that inherently behaves as an interferometer, with output subject to ambient i... | 25,089,457 | [
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Anisotropic reflection oscillation in periodic multilayer structures of parity-time symmetry. | We show that periodic multilayer structures with parity-time (PT) symmetries imposed by a balanced arrangement of gain and loss can exhibit anisotropic reflection oscillation patterns as the number of unit-cells is increasing. At the minima of reflection oscillation patterns, the PT symmetric medium exhibits bidirectio... | 25,089,459 | [
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Multilayer Fresnel zone plates for high energy radiation resolve 21 nm features at 1.2 keV. | X-ray microscopy is a successful technique with applications in several key fields. Fresnel zone plates (FZPs) have been the optical elements driving its success, especially in the soft X-ray range. However, focusing of hard X-rays via FZPs remains a challenge. It is demonstrated here, that two multilayer type FZPs, de... | 25,089,463 | [
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Periodical energy oscillation and pulse splitting in sinusoidal volume holographic grating. | This paper presents dynamical diffraction properties of a femtosecond pulse in a sinusoidal volume holographic grating (VHG). By the modified coupled-wave equations of Kogelnik, we show that the diffraction of a femtosecond pulse on the VHG gives rise to periodical energy oscillation and pulse splitting. In the initial... | 25,089,472 | [
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Subsurface damages of fused silica developed during deterministic small tool polishing. | The subsurface damages (SSD) of fused silica developed during deterministic small tool polishing are experimentally investigated in this study. A leather pad (i.e., poromeric) is validated to be nearly SSD-free and superior to pitch and polyurethane. Rough abrasives are found to obviously increase SSD depth, and a leat... | 25,089,478 | [
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Flexible method based on four-beam interference lithography for fabrication of large areas of perfectly periodic plasmonic arrays. | A novel nanofabrication technique based on 4-beam interference lithography is presented that enables the preparation of large macroscopic areas (>50 mm2) of perfectly periodic and defect-free two-dimensional plasmonic arrays of nanoparticles as small as 100 nm. The technique is based on a special interferometer, com... | 25,089,495 | [
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Heparosan based negatively charged nanocarrier for rapid intracellular drug delivery. | In this study, a heparosan-DOX conjugate (HDC) was designed and prepared by covalently linking heparosan with anticancer drug doxorubicin (DOX) via "Schiff" base. Due to the amphiphilic nature, the HDC could self-assemble into nanoparticles in aqueous solution of pH 7.4. In spite of the surface charge of HDC nanopartic... | 25,089,505 | [
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The Screening Scale for Pedophilic Interests (SSPI): construct, predictive, and incremental validity. | This study of 410 adult male sex offenders against children, using data from the Dynamic Supervision Project (Hanson, Harris, Scott, & Helmus, 2007), examined the construct, predictive, and incremental validity of the Screening Scale for Pedophilic Interests (SSPI; Seto & Lalumière, 2001), a brief proxy measure... | 25,089,535 | [
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Perception of lactose intolerance in irritable bowel syndrome patients. | The importance of lactose malabsorption in irritable bowel syndrome (IBS) is not well defined and these patients often complain of lactose intolerance. To objectively measure lactose malabsorption, a hydrogen breath test (HBT) can be performed, but a discrepancy emerges between the results of the HBT and the symptomati... | 25,089,542 | [
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Mesoscale eddies transport deep-sea sediments. | Mesoscale eddies, which contribute to long-distance water mass transport and biogeochemical budget in the upper ocean, have recently been taken into assessment of the deep-sea hydrodynamic variability. However, how such eddies influence sediment movement in the deepwater environment has not been explored. Here for the ... | 25,089,558 | [
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Role of platelet inhibition in microvascular surgery. | Thrombosis remains a significant complication of microvascular free tissue transfer. Recent discoveries in the field of vascular biology have led to a greater understanding of thrombogenesis and the pivotal role that platelets play in the formation of a clot. However, current antithrombotic strategies in the clinical p... | 25,089,565 | [
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Nerve regeneration: is there an alternative to nervous graft? | In nerve injury with nervous gap, no restitution method was found better than the autograft, however, it has the disadvantage of damaging a normal nerve to be used as a graft. Platelet-rich plasma (PRP) is a possible filler material for vein grafts used as conduits for nerve regeneration, preventing its collapse, and p... | 25,089,566 | [
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Peripheral guidance in scenes: The interaction of scene context and object content. | In the present study, we examined how gaze guidance is affected by immediately available information in the periphery and investigated how search strategies differed across manipulations in the availability of scene context and object content information. Across 3 experiments, participants performed a visual search tas... | 25,089,577 | [
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Fe-TAML encapsulated inside mesoporous silica nanoparticles as peroxidase mimic: femtomolar protein detection. | Peroxidase, such as horseradish peroxidase (HRP), conjugated to antibodies are routinely used for the detection of proteins via an ELISA type assay in which a critical step is the catalytic signal amplification by the enzyme to generate a detectable signal. Synthesis of functional mimics of peroxidase enzyme that displ... | 25,089,579 | [
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Bortezomib improves outcome after SCT in multiple myeloma patients with end-stage renal failure. | Patients with multiple myeloma and dialysis-dependent renal failure have dismal outcomes. In this retrospective analysis of a case series, we evaluated 27 consecutive patients, all of whom required haemodialysis at the time of first-line induction therapy with either bortezomib or a standard regimen followed by high-do... | 25,089,594 | [
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Concentration and acid-base controllable fluorescence of a metallosupramolecular polymer. | A metallosupramolecular polymer (MP-Zn) bearing dibenzo-24-crown-8 (DB24C8) arms is constructed by coordinating Zn(2+) with a conjugated bis-terpyridine ligand, which indicates concentration-dependent emissions from cyan to white to yellow. Successively, reversible emissions are realized by acid-base controllable recog... | 25,089,600 | [
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Nucleolar integrity is required for the maintenance of long-term synaptic plasticity. | Long-term memory (LTM) formation requires new protein synthesis and new gene expression. Based on our work in Aplysia, we hypothesized that the rRNA genes, stimulation-dependent targets of the enzyme Poly(ADP-ribose) polymerase-1 (PARP-1), are primary effectors of the activity-dependent changes in synaptic function tha... | 25,089,620 | [
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Identification of children and adolescents at risk for renal scarring after a first urinary tract infection: a meta-analysis with individual patient data. | No studies have systematically examined the accuracy of clinical, laboratory, and imaging variables in detecting renal scarring in children and adolescents with a first urinary tract infection. To identify independent prognostic factors for the development of renal scarring and to combine these factors in prediction mo... | 25,089,634 | [
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Rare earth element recycling from waste nickel-metal hydride batteries. | With an increase in number of waste nickel-metal hydride batteries, and because of the importance of rare earth elements, the recycling of rare earth elements is becoming increasingly important. In this paper, we investigate the effects of temperature, hydrochloric acid concentration, and leaching time to optimize leac... | 25,089,667 | [
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Being transgender: the experience of transgender identity development. | This article is based on a grounded theory analysis of interviews with transgender-identified people from different regions of the United States. Participants held a variety of gender identities under the transgender rubric (e.g., crossdresser, transman, transwoman, butch lesbian). Interviews explored the participants'... | 25,089,681 | [
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A hybrid model for PM₂.₅ forecasting based on ensemble empirical mode decomposition and a general regression neural network. | Exposure to high concentrations of fine particulate matter (PM₂.₅) can cause serious health problems because PM₂.₅ contains microscopic solid or liquid droplets that are sufficiently small to be ingested deep into human lungs. Thus, daily prediction of PM₂.₅ levels is notably important for regulatory plans that inform ... | 25,089,688 | [
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Inhibition of IL-32 signaling by bamboo salt decreases pro-inflammatory responses in cellular models of allergic rhinitis. | Previously, we showed the antiallergic effect of bamboo salt (BS) in allergic rhinitis (AR). We also demonstrated that interleukin (IL)-32 is an important mediator of AR. The aim of this study was to evaluate the effect and specific underlying mechanism of BS, NaCl, and the mineral mixture (components of BS other than ... | 25,089,715 | [
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Minimally invasive surfactant administration in preterm infants: a meta-narrative review. | Surfactant administration by minimally invasive methods that allow for spontaneous breathing might be safer and more effective than administration with endotracheal intubation and mechanical ventilation; however, the efficacy and safety of minimally invasive methods have not been reviewed. To conduct a meta-narrative r... | 25,089,718 | [
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Rationalization of the pKa values of alcohols and thiols using atomic charge descriptors and its application to the prediction of amino acid pKa's. | In a first step toward the development of an efficient and accurate protocol to estimate amino acids' pKa's in proteins, we present in this work how to reproduce the pKa's of alcohol and thiol based residues (namely tyrosine, serine, and cysteine) in aqueous solution from the knowledge of the experimental pKa's of phen... | 25,089,727 | [
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The effect of NR2B subunit palmitoylation at the spinal level after chronic dorsal root ganglia compression in rats. | The NR2B subunit (N-methyl-D-aspartate receptor 2B subunit) regulates the source of pain, and it participates in the formation of central sensitization. Palmitoylation was shown to be involved in the regulation of N-methyl-D-aspartate receptor internalization. In the present study, we investigated the effects of NR2B s... | 25,089,731 | [
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Prevention of experimental postoperative peritoneal adhesions through the intraperitoneal administration of tanshinone IIA. | Postoperative adhesions develop after nearly every abdominal surgery. The formation of adhesions is associated with the inflammatory response, fibrinolytic system, and extracellular matrix deposition in response to injury. Tanshinone IIA is one of the major extracts obtained from Salvia miltiorrhiza, which has anti-inf... | 25,089,738 | [
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Complicated grief in help-seeking torture survivors in sub-Saharan African contexts. | Many help-seeking torture survivors in sub-Saharan Africa report sudden or violent bereavements, as well as risk factors associated with complicated grief. This mixed-methods article reviews 85 therapeutic client files from torture treatment centers in 3 countries in sub-Saharan Africa. Thirty-nine clients had lost lov... | 25,089,758 | [
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The ecology of gynecological care for women. | Gynecological care is vital to women's health but utilization of gynecological care has been seldom addressed. We applied the population-based "ecology model" to demonstrate the utilization of gynecological care of women, with examples from Taiwan. We analyzed the claims data from the cohort datasets within the Nationa... | 25,089,773 | [
0.1807755,
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0.3815103,
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... |
Assessing program efficiency: a time and motion study of the Mental Health Emergency Care - Rural Access Program in NSW Australia. | The Mental Health Emergency Care-Rural Access Program (MHEC-RAP) is a telehealth solution providing specialist emergency mental health care to rural and remote communities across western NSW, Australia. This is the first time and motion (T&amp;M) study to examine program efficiency and capacity for a telepsychiatry... | 25,089,774 | [
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Synthesis, biological evaluation and 3D-QSAR study of hydrazide, semicarbazide and thiosemicarbazide derivatives of 4-(adamantan-1-yl)quinoline as anti-tuberculosis agents. | We report synthesis, anti-tuberculosis activity and 3D-QSAR study of forty nine hydrazide, semicarbazide and thiosemicarbazide derivatives of 4-(adamantan-1-yl)quinoline. The most potent compounds upon evaluation for anti-tuberculosis activity exhibited MIC99 of 3.125 μg/mL against Mycobacterium tuberculosis H37Rv stra... | 25,089,809 | [
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0.1710... |
In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives. | An in vitro investigation of the antiplasmodial and cytotoxic activities of a series of human choline kinase inhibitors against Plasmodium falciparum is reported. Structure-activity relationship analyses have allowed us to determine the essential parameters for the antimalarial effect of these asymmetrical pyridinium d... | 25,089,811 | [
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0... |
Barbs facilitate the helical penetration of honeybee (Apis mellifera ligustica) stingers. | The stinger is a very small and efficient device that allows honeybees to perform two main physiological activities: repelling enemies and laying eggs for reproduction. In this study, we explored the specific characteristics of stinger penetration, where we focused on its movements and the effects of it microstructure.... | 25,089,826 | [
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Investigating the effects of resveratrol on chronically ischemic myocardium in a swine model of metabolic syndrome: a proteomics analysis. | Resveratrol has been shown to improve cardiac perfusion and ventricular function after chronic ischemic injury. Using proteomic analysis, we sought to objectively investigate potential mechanisms, by which resveratrol exerts its cardioprotective effects in the setting of metabolic syndrome and chronic myocardial ischem... | 25,089,828 | [
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0.232674,
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-... |
The constituents of roots and stems of Illigera luzonensis and their anti-platelet aggregation effects. | Phytochemical investigation of the roots and stems of Illigera luzonensis afforded two new aporphine alkaloids (1) and (2), one new bisdehydroaporphine alkaloid (3), and one new benzenoid (4), along with 28 known structures. The structures of new compounds were elucidated by spectral and MS analysis. Among the isolated... | 25,089,876 | [
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The mitochondrion-located protein OsB12D1 enhances flooding tolerance during seed germination and early seedling growth in rice. | B12D belongs to a function unknown subgroup of the Balem (Barley aleurone and embryo) proteins. In our previous work on rice seed germination, we identified a B12D-like protein encoded by LOC_Os7g41350 (named OsB12D1). OsB12D1 pertains to an ancient protein family with an amino acid sequence highly conserved from moss ... | 25,089,878 | [
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0.240464,
0.3293754,
0.5128977,
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0.... |
Press fluid pre-treatment optimisation of the integrated generation of solid fuel and biogas from biomass (IFBB) process approach. | The integrated generation of solid fuel and biogas from biomass (IFBB) system is an innovative approach to maximising energy conversion from low input high diversity (LIHD) biomass. In this system water pre-treated and ensiled LIHD biomass is pressed. The press fluid is anaerobically digested to produce methane that is... | 25,089,895 | [
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0.0007233356,
0.238468,
0.182478,
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... |
Phosphorus availability from the solid fraction of pig slurry is altered by composting or thermal treatment. | The alteration of easily available phosphorus (P) from the separated solid fraction of pig slurry by composting and thermal processing (pyrolysis or combustion at 300-1000 °C) was investigated by water and acidic extractions and the diffusive gradients in thin films (DGT) technique. Temporal changes in P availability w... | 25,089,896 | [
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0.1390446,
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... |
Addition of omega-3 carboxylic acids to statin therapy in patients with persistent hypertriglyceridemia. | The incidence of hypertriglyceridemia has grown alongside that of obesity. Statin therapy has been widely recommended for the treatment of dyslipidemias. Omega-3 (OM3) fatty acid concentrates are commonly prescribed concurrently with statins in patients with persistent hypertriglyceridemia for additional lowering of tr... | 25,089,906 | [
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0.2752008,
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0.4125218,
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... |
REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population. | REV-ERB ALPHA has been shown to link metabolism with circadian rhythms. We aimed to identify new polymorphisms in the promoter of REV-ERB ALPHA and tested whether these polymorphisms could be associated with obesity in the Spanish population. Of the 1197 subjects included in our study, 779 were obese (BMI 34.38±3.1 kg/... | 25,089,907 | [
-0.05493714,
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0.1392299,
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0.2385092,
-0.1816... |
Decitabine suspends human CD34+ cell differentiation and proliferation during lentiviral transduction. | Efficient ex vivo transduction of hematopoietic stem cells (HSCs) is encumbered by differentiation which reduces engraftment. We hypothesized that inhibiting DNA methyltransferase with decitabine would block differentiation of transduced CD34+ cells under cytokine stimulation and thus improve transduction efficiency fo... | 25,089,909 | [
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-0.377021,
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0.3381917,
0.2357896,
0.1211775,
-0.02973... |
Autosomal recessive cerebellar ataxia type 3 due to ANO10 mutations: delineation and genotype-phenotype correlation study. | ANO10 mutations have been reported to cause a novel form of autosomal recessive cerebellar ataxia (ARCA). Our objective was to report 9 ataxic patients carrying 8 novel ANO10 mutations to improve the delineation of this form of ARCA and provide genotype-phenotype correlation. The ANO10 gene has been sequenced in 186 co... | 25,089,919 | [
0.08999948,
0.08474706,
0.1220561,
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0.003149232,
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0.07897165,
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0.1637697,
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-0.3131169,
0.5986312,
0.1053938,
0.1277263,
... |
Bi3Cr2.91O11: a ferromagnetic insulator from Cr(4+)/Cr(5+) mixing. | The search for materials with ferromagnetic and semiconducting/insulating properties has intensified recently because of their potential use in spintronics. However, the number of materials is rather limited because of conflicting requirements needed for the appearance of ferromagnetic and insulating properties. Here w... | 25,089,932 | [
0.005965308,
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0.1036871,
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0.00274941,
0.142673,
0.07434505,
0.03198258,
0.1998192,
-0.1004... |
Respiratory sinus arrhythmia during worry forecasts stress-related increases in psychological distress. | Respiratory sinus arrhythmia (RSA) has been conceptualized as an index of emotion regulation abilities. Although resting RSA has been associated with both concurrent and prospective affective responses to stress, the impact of RSA reactivity on emotional responses to stress is inconsistent across studies. The type of e... | 25,089,936 | [
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0.403023,
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-0.06792716,
-0.1447... |
Synthesis of toroidal gold nanoparticles assisted by soft templates. | A three-component system comprising surfactant molecules and molecularly cross-linked metal centers assembles into nanoring structures. The thickness of the nanorings is determined by the dimensions of the surfactant bilayer while the dimensions of the ring opening depend on and can be regulated by the concentrations o... | 25,089,938 | [
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0.0766627,
-0.08282661,
-0.003231959,
0.1576817,
0.161346,
-0.1574525,
... |
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