title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells. | AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans. Since these exhibit potent antitumor activity and have immunomodulatory effects, the stimulatory effect of AndoSan on the ... | 25,136,950 | [
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Inside money, procyclical leverage, and banking catastrophes. | We explore a model of the interaction between banks and outside investors in which the ability of banks to issue inside money (short-term liabilities believed to be convertible into currency at par) can generate a collapse in asset prices and widespread bank insolvency. The banks and investors share a common belief abo... | 25,136,959 | [
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A model for implementing guidelines for person-centered care in a nursing home setting. | Systematic evaluations of knowledge translation interventions in nursing homes to improve practice are scarce. There is also a lack of studies focusing on creating sustainable evidence-based practice in the setting of residential dementia care. The aim of this paper is to describe a model for implementing national evid... | 25,136,961 | [
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Transcriptional profiling in rat hair follicles following simulated Blast insult: a new diagnostic tool for traumatic brain injury. | With wide adoption of explosive-dependent weaponry during military activities, Blast-induced neurotrauma (BINT)-induced traumatic brain injury (TBI) has become a significant medical issue. Therefore, a robust and accessible biomarker system is in demand for effective and efficient TBI diagnosis. Such systems will also ... | 25,136,963 | [
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Age-stratified 5-year risks of cervical precancer among women with enrollment and newly detected HPV infection. | It is unclear whether a woman's age influences her risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) upon detection of HPV. A large change in risk as women age would influence vaccination and screening policies. Among 972,029 women age 30-64 undergoing screening with Pap and HPV testing (Hybrid Captur... | 25,136,967 | [
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Registration of 2D histological sections with 3D micro-CT datasets from small animal vertebrae and tibiae. | The aim of this study was the registration of digitized thin 2D sections of mouse vertebrae and tibiae used for histomorphometry of trabecular bone structure into 3D micro computed tomography (μCT) datasets of the samples from which the sections were prepared. Intensity-based and segmentation-based registrations (SegRe... | 25,136,982 | [
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Sequential inclusion of two berberine cations in cucurbit[8]uril cavity: kinetic and thermodynamic studies. | A combination of absorption and fluorescence spectroscopic studies with isothermal calorimetric titrations and stopped-flow measurements is a powerful way to reveal the thermodynamics and kinetics of inclusion complex formation with cucurbit[8]uril (CB8). The unique photophysical characteristics of berberine (B(+)), a ... | 25,136,985 | [
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The potential impact of a 20% tax on sugar-sweetened beverages on obesity in South African adults: a mathematical model. | The prevalence of obesity in South Africa has risen sharply, as has the consumption of sugar-sweetened beverages (SSBs). Research shows that consumption of SSBs leads to weight gain in both adults and children, and reducing SSBs will significantly impact the prevalence of obesity and its related diseases. We estimated ... | 25,136,987 | [
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Non-injection synthesis of doped zinc oxide plasmonic nanocrystals. | Plasmonic metal oxide nanocrystals bridge the optoelectronic gap between semiconductors and metals. In this study, we report a facile, non-injection synthesis of ZnO nanocrystals doped with Al, Ga, or In. The reaction readily permits dopant/zinc atomic ratios of over 15%, is amenable to high precursor concentrations (0... | 25,136,989 | [
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Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery. | Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique. The aim of this study was to analytically validate the applicability of I-FISH in assessing 9p deleti... | 25,137,021 | [
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Comparison of interferon-γ release assay to two cut-off points of tuberculin skin test to detect latent Mycobacterium tuberculosis infection in primary health care workers. | An interferon-γ release assay, QuantiFERON-TB (QFT) test, has been introduced an alternative test for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI). Here, we compared the performance of QFT with tuberculin skin test (TST) measured at two different cut-off points among primary health care work (HCW... | 25,137,040 | [
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Coupling of X-chromosome reactivation with the pluripotent stem cell state. | X-chromosome inactivation (XCI) in female mammals is a dramatic example of epigenetic gene regulation, which entails the silencing of an entire chromosome through a wide range of mechanisms involving noncoding RNAs, chromatin-modifications, and DNA-methylation. While XCI is associated with the differentiated cell state... | 25,137,047 | [
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Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. | To determine the association between diabetes mellitus (DM) and primary open-angle glaucoma (POAG). This is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases (PubMed and Embase) and the reference lists of the retrieved studies. Separate meta-analyses ... | 25,137,059 | [
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Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia. | Here we present a novel method "Genomic inverse PCR for exploration of ligated breakpoints" (GIPFEL) that allows the sensitive detection of recurrent chromosomal translocations. This technique utilizes limited amounts of DNA as starting material and relies on PCR based quantification of unique DNA sequences that are cr... | 25,137,060 | [
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High proton conduction at above 100 °C mediated by hydrogen bonding in a lanthanide metal-organic framework. | A lanthanide metal-organic framework (MOF) compound of the formulation [Eu2(CO3)(ox)2(H2O)2]·4H2O (1, ox = oxalate) was prepared by hydrothermal synthesis with its structure determined crystallographically. Temperature-dependent but humidity-independent high proton conduction was observed with a maximum of 2.08 × 10(-3... | 25,137,095 | [
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Germination shifts of C3 and C4 species under simulated global warming scenario. | Research efforts around the world have been increasingly devoted to investigating changes in C3 and C4 species' abundance or distribution with global warming, as they provide important insight into carbon fluxes and linked biogeochemical cycles. However, changes in the early life stage (e.g. germination) of C3 and C4 s... | 25,137,138 | [
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Surgical treatment of large abdominally involved primary dumbbell tumor in the lumbar region. | This was a retrospective clinical study. The aim of this study was to assess the efficacy of a combined anterior and posterior approach, or single-stage posterior extensive approach for resection of large abdominally involved dumbbell tumor in the lumbar region. Resection of the large spinal-retroperitoneal involved du... | 25,137,145 | [
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Stereoselective synthesis of C-fused pyranoindoles, pyranobenzofurans and pyranobenzothiophene scaffolds using oxa-Pictet-Spengler type reaction of vinylogous carbonates. | C-fused pyranoheterocycles can be readily assembled using an intramolecular oxa-Pictet-Spengler type reaction of vinylogous carbonates in a highly stereoselective manner. Required indole and benzofuran rings tethered to vinylogous carbonates are prepared by a tandem Sonogashira coupling-nucleopalladation reaction. The ... | 25,137,156 | [
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[Intravenous drugs infusion safety through smart pumps]. | To analyze the role of smart infusion pumps in reducing errors related with the administration of intravenous medications. Retrospective, observational study analyzing the implementation of a system with smart intravenous infusion pumps (Hospira MedNetTM) and the role of the safety system for the detection of errors du... | 25,137,160 | [
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Assessment of EGFR mutations in circulating tumor cell preparations from NSCLC patients by next generation sequencing: toward a real-time liquid biopsy for treatment. | Assessment of EGFR mutation in non-small cell lung cancer (NSCLC) patients is mandatory for optimization of pharmacologic treatment. In this respect, mutation analysis of circulating tumor cells (CTCs) may be desirable since they may provide real-time information on patient's disease status. Blood samples were collecte... | 25,137,181 | [
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[Patient safety -- mission for the future: Managing complications: what do I tell to the patients and what to the relatives?]. | In cases of unintended treatment courses an adequate communication is mandatory. Empathetic conversations expressing human warmth can pave the way to the avoidance of forensic consequences. The laws on patient's rights obligate the responsible physician to inform on request the patient about all recognizable circumstan... | 25,137,204 | [
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Deposition of Particles in Human Mouth-Throat Replicas and a USP Induction Port. | Oral inhalation is the common route of drug delivery to pulmonary airways. In general, deposition in the oropharyngeal airways from a drug-delivery device makes up a substantial portion of the emitted dose, which affects the dose delivered to the lung. Studies with airway replicas made from cadaver or magnetic resonanc... | 25,137,223 | [
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Sex-specific relationships of physical activity, body composition, and muscle quality with lower-extremity physical function in older men and women. | This study aims to determine the sex-specific relationships of physical activity, body composition, and muscle quality with lower-extremity physical function in older men and women. Seventy-nine community-dwelling men (n = 39; mean [SD] age, 76.1 [6.2] y; mean [SD] body mass index, 27.3 [3.8] kg/m(2)) and women (n = 40... | 25,137,244 | [
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Thrombopoietin treatment of one graft in a double cord blood transplant provides early platelet recovery while contributing to long-term engraftment in NSG mice. | Human cord blood (CB) hematopoietic stem cell (HSC) transplants demonstrate delayed early neutrophil and platelet recovery and delayed longer term immune reconstitution compared to bone marrow and mobilized peripheral blood transplants. Despite advances in enhancing early neutrophil engraftment, platelet recovery after... | 25,137,252 | [
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Hypertriglyceridemic waist phenotype: association with metabolic disorders and visceral fat in adults. | To evaluate the association of Hypertriglyceridemic waist with metabolic disorders and visceral fat in adults. Cross-sectional study with 191 individuals of both sexes. Subjects were grouped according to Waist Circumference (WC) ratings (Men: > 90 cm; Women: > 80 cm) and triglycerides (TG) (> 150 mg/dl) in Gro... | 25,137,258 | [
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Psychological well-being in a sample of obese patients compared with a control group. | The literature has found that obese patients usually report more depression and anxiety than normal weight individuals. However, not many investigations have studied the relationship between obesity and quality of life from a Positive Psychology approach. In this study it is analyzed if obese patients have less psychol... | 25,137,259 | [
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Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted. | To evaluate the differences in frequency of fat-soluble vitamin deficiencies if we adjust their levels by its main carriers in plasma in patients undergoing Biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). We recruited 178 patients who underwent RYGB (n = 116 patients) and BPD (n = 62 patients) in a... | 25,137,270 | [
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[Body composition and heart rate variability in patients with chronic obstructive pulmonary disease pulmonary rehabilitation candidates]. | Body composition is a non-invasive method, which gives us information about the distribution of tissues in the body structure, it is also an indicator of the risk of mortality in patients with chronic obstructive pulmonary disease. The heart rate variability is a technique that gives us information of autonomic physiol... | 25,137,278 | [
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Molecular characterization and expression analysis of the critical floral genes in hickory (Carya cathayensis Sarg.). | The full ORFs of three floral genes in hickory (Carya cathayensis Sarg.), CcAGL24 (the AGAMOUS-LIKE24 homolog), CcSOC1 (the SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 homolog) and CcAP1 (the APETALA1 homolog) are derived using a 5' RACE PCR protocol. Through sequence alignment and phylogenetic analysis, it is demonstrat... | 25,137,292 | [
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[Intravascular papillary endothelial hyperplasia of the lung]. | We report a rare case of pulmonary intravascular papillary endothelial hyperplasia. The patient was a 63-year-old male. Multiple lung nodules were noted on chest computed tomography( CT) at preoperative check for gastric cancer. Metastatic lung tumor was suspected, and partial resection of the right lung was performed.... | 25,137,319 | [
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Reconstructing Austronesian population history in Island Southeast Asia. | Austronesian languages are spread across half the globe, from Easter Island to Madagascar. Evidence from linguistics and archaeology indicates that the 'Austronesian expansion,' which began 4,000-5,000 years ago, likely had roots in Taiwan, but the ancestry of present-day Austronesian-speaking populations remains contr... | 25,137,359 | [
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Development of an organic lateral resolution test device for imaging mass spectrometry. | An organic lateral resolution test device has been developed to measure the performance of imaging mass spectrometry (IMS) systems. The device contains periodic gratings of polyethylene glycol (PEG) and lipid bars covering a wide range of spatial frequencies. Microfabrication technologies were employed to produce well-... | 25,137,365 | [
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Reconciling "stress" and "health" in physical anthropology: what can bioarchaeologists learn from the other subdisciplines? | The concepts of "stress" and "health" are foundational in physical anthropology as guidelines for interpreting human behavior and biocultural adaptation in the past and present. Though related, stress and health are not coterminous, and while the term "health" encompasses some aspects of "stress," health refers to a mo... | 25,137,366 | [
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Accelerometer adherence and performance in a cohort study of US Hispanic adults. | This study described participant adherence to wearing the accelerometer and accelerometer performance in a cohort study of adults. From 2008 to 2011, 16,415 US Hispanic/Latino adults age 18-74 yr enrolled in the Hispanic Community Health Study/Study of Latinos. Immediately after the baseline visit, participants wore an... | 25,137,369 | [
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Long-term fertilization modifies the structures of soil fulvic acids and their binding capability with Al. | The binding characteristics of organic ligands and minerals in fulvic acids (FAs) with Al are essential for understanding soil C sequestration, remain poorly understood. In this study, Fourier transform infrared (FTIR) spectroscopy combined with two-dimensional correlation spectroscopy (2DCOS) analysis was applied for ... | 25,137,372 | [
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Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria. | We developed a new class of covalent inhibitors of Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase, a validated target for the treatment of malaria, by screening a small library of 3-bromo-isoxazoline derivatives that inactivate the enzyme through a covalent, selective bond to the catalytic cysteine, as ... | 25,137,375 | [
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Susceptibility-weighted imaging in heat stroke. | To assess the role of susceptibility-weighted imaging in the detection of intracranial hemorrhage after heat stroke and in the prognosis. The study group consisted of eight patients after heat stroke, with a score of 3 to 9 in Glasgow Coma Scale. The MR studies were performed with a 1.5 T scanner. Susceptibility-weight... | 25,137,376 | [
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Impact of fresh organic matter incorporation on PAH fate in a contaminated industrial soil. | The impacts of fresh organic matter (OM) incorporation in an industrial PAH-contaminated soil on its structure and contaminant concentrations (available and total) were monitored. A control soil and a soil amended with the equivalent of 10 years maize residue input were incubated in laboratory-controlled conditions ove... | 25,137,382 | [
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AgONO-assisted direct C-H arylation of heteroarenes with anilines. | A novel copper-catalyzed C-H arylation of heteroarenes with anilines by an in situ diazonium reaction is established by using silver nitrite (AgONO) as an unconventional nitrosating reagent under acid-free conditions. It provides a complementary approach for the C-H arylation of electron-rich heteroarenes with aromatic... | 25,137,410 | [
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Letrozole vs anastrozole for height augmentation in short pubertal males: first year data. | Aromatase inhibitors are used off-label to treat short stature in peripubertal boys. To investigate short- and long-term hormonal and auxologic differences in short pubertal boys treated with letrozole (L) or anastrozole (A). PATIENTS are seen for laboratory evaluation and physical examination every 6 months, bone age ... | 25,137,428 | [
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Amide proton transfer-weighted imaging of the head and neck at 3 T: a feasibility study on healthy human subjects and patients with head and neck cancer. | The aim of this study was to explore the feasibility and repeatability of amide proton transfer-weighted (APTw) MRI for the head and neck on clinical MRI scanners. Six healthy volunteers and four patients with head and neck tumors underwent APTw MRI scanning at 3 T. The APTw signal was quantified by the asymmetric magn... | 25,137,521 | [
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Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. | Sphingosine 1-phosphate (S1P), a bioactive lipid involved in various physiological processes, can be irreversibly degraded by the membrane-bound S1P lyase (S1PL) yielding (2E)-hexadecenal and phosphoethanolamine. It is discussed that (2E)-hexadecenal is further oxidized to (2E)-hexadecenoic acid by the long-chain fatty... | 25,137,547 | [
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Distorted subjective reports of stimulus onsets under dual-task conditions: Delayed conscious perception or estimation bias? | We investigated whether selecting a response for one task delays the conscious perception of another stimulus (delayed conscious perception hypothesis). In two experiments, participants watched a revolving clock hand while performing two tasks in close succession (i.e. a dual-task). Two stimuli were presented with vary... | 25,137,569 | [
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Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial pathway. | Silver complexes have been shown to possess antimicrobial and anticancer properties. Ag-SP-DNC, a novel silver and singly protonated dehydronorcantharidin complex, was synthesized in our previous study. In this study, we offer evidence that Ag-SP-DNC elicits a reactive oxygen species (ROS)-mediated mitochondrial apopto... | 25,137,572 | [
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Object perception: where do we see the weight? | A new study of the response of the human brain as subjects view objects of different weights they are about to lift shows that the weight of objects, which influences the way we act upon them, is represented in the ventral stream of the visual cortex. | 25,137,583 | [
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Behavioral sequencing: competitive queuing in the fly CNS. | A study of grooming behaviors in Drosophila suggests a neuronal mechanism for how animals produce complex motor patterns from ordered interactions among modules of different motor acts. This mechanism may be a common one in many nervous systems. | 25,137,585 | [
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Genetics: finding genes for schizophrenia. | New studies have substantially advanced our understanding of the genetic architecture of schizophrenia, but we are far from identifying the underlying mutations. We may require new approaches to understand the biological implications of insights into the genetics of psychiatric disease. | 25,137,590 | [
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Aberrant regulation and function of microRNAs in cancer. | Malignant neoplasms are consistently among the top four leading causes of death in all age groups in the United States, despite a concerted effort toward developing novel therapeutic approaches. Our understanding of and therapeutic strategy for treating each of these neoplastic diseases have been improved through decad... | 25,137,592 | [
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Effective ion mobility calculations for macromolecules by scattering on electron clouds. | Broad commercialization and increasing resolving power of ion mobility spectrometry/mass spectrometry (IMS/MS) platforms have engendered an explosion of IMS applications to structural characterization of gas-phase biomolecules. That has renewed interest in more accurate and rapid ion mobility calculations that are need... | 25,137,627 | [
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Low-density lipoprotein-mimicking nanoparticles for tumor-targeted theranostic applications. | This study introduces multifunctional lipid nanoparticles (LNPs), mimicking the structure and compositions of low-density lipoproteins, for the tumor-targeted co-delivery of anti-cancer drugs and superparamagnetic nanocrystals. Paclitaxel (4.7 wt%) and iron oxide nanocrystals (6.8 wt%, 11 nm in diameter) are co-encapsu... | 25,137,631 | [
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Healthcare system and the wealth-health gradient: a comparative study of older populations in six countries. | The present study provides a comparative analysis of the association between wealth and health in six healthcare systems (Sweden, the United Kingdom, Germany, the Czech Republic, Israel, the United States). National samples of individuals fifty years and over reveal considerable cross-country variations in health outco... | 25,137,644 | [
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Maximal entropy random walk for region-based visual saliency. | Visual saliency is attracting more and more research attention since it is beneficial to many computer vision applications. In this paper, we propose a novel bottom-up saliency model for detecting salient objects in natural images. First, inspired by the recent advance in the realm of statistical thermodynamics, we ado... | 25,137,693 | [
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Four-class classification of skin lesions with task decomposition strategy. | This paper proposes a new computer-aided method for the skin lesion classification applicable to both melanocytic skin lesions (MSLs) and nonmelanocytic skin lesions (NoMSLs). The computer-aided skin lesion classification has drawn attention as an aid for detection of skin cancers. Several researchers have developed me... | 25,137,721 | [
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A dual-population differential evolution with coevolution for constrained optimization. | Inspired by the fact that in modern society, team cooperation and the division of labor play important roles in accomplishing a task, this paper proposes a dual-population differential evolution (DPDE) with coevolution for constrained optimization problems (COPs). The COP is treated as a bi-objective optimization probl... | 25,137,739 | [
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Taste dysfunction and eating behaviors in survivors of head and neck cancer treatment. | Radiation, chemotherapy, and surgery result in eating problems for patients with head and neck cancer. Eating is essential to physical and social functioning. Strategies for head and neck cancer survivors to cope with eating and taste impairments are reported in this study. | 25,137,792 | [
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0.001245631,
0.3553754,
0.01913... |
[Therapeutic effect of Astragalus and Angelica mixture on the renal function and TCM syndrome factors in treating stage 3 and 4 chronic kidney disease patients]. | To compare the therapeutic effect of Astragalus and Angelica Mixture (AAM) on treating CKD patients according to different CKD primary diseases, staging and TCM syndromes. A multicentre, open-label, and self control clinical design was used, and thirty-two patients in line with inclusive criteria were recruited. Based ... | 25,137,839 | [
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[Renal protection of Tangke Decoction on rats with diabetes and its effect on the expression of TGF-beta1/Smad4]. | To observe the effect of Tangke Decoction (TD) on the expression of TGF-beta1/Smad4 of rats with early diabetes and to explore the effect and mechanism of TD against the renal injury induced by diabetes. SD rats were randomly divided into the normal control group (n = 12), the model group (n = 10), the Chinese herbs pr... | 25,137,849 | [
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[Effect of advanced glycation end products on the function and angiogenesis of adipose tissue-derived stem cells and the protective effect of danhong injection: an experimental study]. | OBJECTIVE To investigate the effect of Nepsilon-(carboxymethyl) lysine albumin (CMLs), a primary advanced glycation end products (AGEPs) isoform in diabetic body, on the function and angiogenesis of adipose tissue-derived stem cells (ADSCs) and the protective effect of Danhong Injection (DH). METHODS Human ADSCs were c... | 25,137,851 | [
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[Effect of zhenqing recipe on non-alcoholic fatty liver in type 2 diabetes rats and the expression of SIK1]. | To observe the effect of Zhenqing Recipe (ZQR) on non-alcoholic fatty liver (NAFL), and the expression of hepatic salt-inducible kinase 1 (SIK1) and sterol-regulatory element binding protein-ic (SREBP-lc) in type 2 diabetes rats. A rat model of type 2 diabetes was established by high fat/sucrose diet combined with intr... | 25,137,852 | [
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[Effect of Mudan Granule on islets beta cell function in monosodium glutamate induced obese mice with insulin resistance: an experimental study]. | To study the effect of Mudan Granule (MD) on the glucose metabolism and beta cell function in monosodium glutamate (MSG) induced obese mice with insulin resistance (IR). MSG obese mice were induced by subcutaneous injecting MSG (4 g/kg for 7 successive days in neonatal ICR mice). Forty MSG mice with IR features were re... | 25,137,853 | [
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Acetabular cup placement in navigated and non-navigated total hip arthroplasty (THA): results of two consecutive series using a cementless short stem. | Acetabular component malposition has been linked to increased rates of dislocation, impingement, pelvic osteolysis, cup migration, leg length discrepancy and polyethylene wear in patients undergoing total hip arthroplasty (THA). Compare the acetabular component positioning and the operative time in two consecutive shor... | 25,137,880 | [
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Diagnostic properties of the STOP-Bang and its modified version in screening for obstructive sleep apnea in Thai patients. | To test the diagnostic properties of the original and a modified STOP-Bang, as well as testing the additional use of a waist-to-height ratio (WHtR) of > or = 0.55 in screening for obstructive sleep apnea (OSA) in Thai patients. Three hundred and three patients (186 males and 117 females) who underwent anthropometric... | 25,137,882 | [
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[Leukoaraiosis as a cause of non-arteritic anterior ischemic optic neuropathy--a case report]. | The paper presents the case of a 61-year-old man with specific symptoms of non-arteritic anterior ischemic optic neuropathy. The head computed tomographyscans revealed multiple leukoaraiotic lesions. Leukoaraiosis is a disease affecting small cerebral vessels. Its pathogenesis is associated with a chronic inflammatory ... | 25,137,919 | [
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[Terson syndrome--a literature review]. | Tersone syndrome was first described in 1900 as haemorrhages in the eye that occur as a consequence of intracranial hemorrhage. The main cause of the syndrome in adults is a subarachnoid hemorrhage following the rupture of intracranial aneurysm. The pathogenesis has not been fully understood. It is believed that the in... | 25,137,925 | [
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[A simple tool to measure the immediate wellbeing of elderly people in nursing homes]. | Immediate wellbeing and quality of life in an institution are of paramount importance. The assessment of the quality of life of elderly people is both complex and poorly adapted to daily practices. The instant assessment of wellbeing tool (EVIBE), developed in the field, is an original and practical alternative. This t... | 25,137,958 | [
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An overview of the sequence features of N- and C-terminal segments of the human chemokine receptors. | Chemokine receptors play a crucial role in the cellular signaling enrolling extracellular ligands chemotactic proteins which recruit immune cells. They possess seven trans-membrane helices, an extracellular N-terminal region with three extracellular hydrophilic loops being important for search and recognition of specif... | 25,138,014 | [
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Repeating pulmonary rehabilitation: prevalence, predictors and outcomes. | Pulmonary rehabilitation (PR) is a cornerstone of care in chronic respiratory diseases; yet its benefits diminish over time. Repeating PR may be beneficial; however, little is known about the characteristics and outcomes of repeaters. This study aimed to establish the proportion of repeaters, identify characteristics t... | 25,138,020 | [
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The reliability of fetal MRI in the assessment of brain malformations. | To assess the inter- and intraobserver reliability of different fetal MRI measurements in cases of fetal brain malformations and to examine the concordance between ultrasonography (US) and MRI findings. Fetal brain MRIs and US findings of 56 pregnant women were retrieved from the institutional database. Standardized fe... | 25,138,047 | [
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Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma. | Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to chemotherapy warrants new strategies still needed to improve overall patient survival. Among new therapeutic approaches, zoledronic acid (ZOL) represents a promising adjuvant molecule to chemotherapy t... | 25,138,053 | [
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Ranolazine as a promising treatment option for atrial fibrillation: electrophysiologic mechanisms, experimental evidence, and clinical implications. | Currently available agents for pharmacologic management of atrial fibrillation (AF) are limited by their suboptimal efficacy and nonnegligible proarrhythmic risk. Ranolazine (RN) is a novel antianginal agent with increasingly appreciated antiarrhythmic properties that can suppress ventricular and supraventricular arrhy... | 25,138,058 | [
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Exsheathment and midgut invasion of nocturnally subperiodic Brugia malayi microfilariae in a refractory vector, Aedes aegypti (Thailand strain). | Exsheathment and midgut invasion of nocturnally subperiodic Brugia malayi microfilariae were analyzed using light and scanning electron microscopy in a refractory vector, Aedes aegypti (Thailand strain). Results showed that exsheathed microfilariae represented only approximately 1% of the total microfilaria midguts dis... | 25,138,070 | [
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Inhibitory effect of plantaricin peptides (Pln E/F and J/K) against Escherichia coli. | Plantaricins are small bioactive peptides produced by Lactobacillus plantarum strains that exhibit significant antimicrobial activity against closely-related Gram-positive bacteria, including food spoilage organisms. In comparison, bacteriocins including plantaricins, are usually less effective against Gram-negative or... | 25,138,074 | [
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Proteomic investigation of the hippocampus in prenatally stressed mice implicates changes in membrane trafficking, cytoskeletal, and metabolic function. | Prenatal stress influences the development of the fetal brain and so contributes to the risk of the development of psychiatric disorders in later life. The hippocampus is particularly sensitive to prenatal stress, and robust abnormalities have been described in the hippocampus in schizophrenia and depression. The aim o... | 25,138,076 | [
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Drug targeting systems for cancer therapy: nanotechnological approach. | Progress in cancer treatment remains challenging because of the great nature of tumor cells to be drug resistant. However, advances in the field of nanotechnology have enabled the delivery of drugs for cancer treatment by passively and actively targeting to tumor cells with nanoparticles. Dramatic improvements in nanot... | 25,138,089 | [
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Bioinspired design and assembly of layered double hydroxide/poly(vinyl alcohol) film with high mechanical performance. | Inspired by the hierarchical structure and excellent mechanical performance of nacre, LDH nanosheets with an appropriate aspect ratio to withstand significant loads and at the same time allow for rupture under the pull-out mode were synthesized as artificial building blocks for the fabrication of nacre-like films. Mult... | 25,138,146 | [
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Vocal fold paresis accompanying vocal fold polyps. | The aim of this study was to evaluate patients with vocal fold polyps using laryngeal electromyography (LEMG) for the presence of vocal fold paresis and to compare transnasal fiberoptic and rigid stroboscopic findings between polyp patients with normal LEMG and with vocal fold paresis. Thirty-five patients with a vocal... | 25,138,152 | [
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The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition. | Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function, desquamation, and inflammation. In this study, we addressed the consequences of a catalytically dead serine protease o... | 25,138,159 | [
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Pepper: cytoscape app for protein complex expansion using protein-protein interaction networks. | We introduce Pepper (Protein complex Expansion using Protein-Protein intERactions), a Cytoscape app designed to identify protein complexes as densely connected subnetworks from seed lists of proteins derived from proteomic studies. Pepper identifies connected subgraph by using multi-objective optimization involving two... | 25,138,169 | [
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Comparison of bivalirudin and heparin in patients undergoing rotational atherectomy: a subanalysis of the randomised ROTAXUS trial. | Bivalirudin has emerged as a meaningful alternative to heparin in patients undergoing percutaneous coronary intervention (PCI). To date, it is unclear whether bivalirudin has advantages in patients undergoing rotational atherectomy (RA). The current subgroup analysis of the ROTAXUS trial compared patients receiving biv... | 25,138,183 | [
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Hospice Comics: Representations of Patient and Family Experience of Illness and Death in Graphic Novels. | Non-fiction graphic novels about illness and death created by patients and their loved ones have much to teach all readers. However, the bond of empathy made possible in the comic form may have special lessons for healthcare providers who read these texts and are open to the insights they provide. | 25,138,207 | [
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Waveband selection of reagent-free determination for thalassemia screening indicators using Fourier transform infrared spectroscopy with attenuated total reflection. | A reagent-free determination method for the thalassemia screening indicators hemoglobin (Hb), mean corpuscular Hb (MCH), and mean corpuscular volume (MCV) was developed based on Fourier transform infrared spectrometers equipped with an attenuated total reflection accessory. A random and stability-dependent rigorous pro... | 25,138,209 | [
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Secretoneurin as a marker for hypoxic brain injury after cardiopulmonary resuscitation. | The neuropeptide secretoneurin (SN) shows widespread distribution in the brain. We evaluated whether SN is elevated after cardiopulmonary resuscitation (CPR) and could serve as a potential new biomarker for hypoxic brain injury after CPR. This was a prospective observational clinical study. All patients admitted to a t... | 25,138,227 | [
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... |
Impaired left atrial function in heart failure with preserved ejection fraction. | Left atrial (LA) enlargement is present in the majority of heart failure with preserved ejection fraction (HFpEF) patients and is a marker of risk. However, the importance of LA function in HFpEF is less well understood. The PARAMOUNT trial enrolled HFpEF patients (LVEF ≥45%, NT-proBNP >400 pg/mL). We assessed LA re... | 25,138,249 | [
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0.07518914,
0.02142788,
0.183616,
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Enhancement in bioavailability of ketorolac tromethamine via intranasal in situ hydrogel based on poloxamer 407 and carrageenan. | The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan-poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine. CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow erosi... | 25,138,250 | [
0.08928718,
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0.1766318,
0.3399722,
0.1919308,... |
Amorphous isradipine nanosuspension by the sonoprecipitation method. | The aims of this study are to increase and explain the mechanism of dissolution enhancement of isradipine using the sonoprecipitation method for stable nanosuspensions. There have been still few of published researches on formulation of isradipine using nanoparticle engineering. Nanosuspension systems were prepared upo... | 25,138,256 | [
-0.3419729,
-0.1949077,
0.1128881,
0.1948067,
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0.0192848,
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0.03771537,
0.3799882,
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0.07097827,
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-0.250928,
-0.1797829,
0.05733149,
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0.1106752,
0.0... |
Why did the proton cross the road? Humour and science communication. | The use of humour in public discourse about science has grown remarkably over the past few years, and when used in science communication activities is being seen as a great way to bring science to the public through laughter. However, barely any research has been published either on the often-assumed beneficial learnin... | 25,138,269 | [
-0.3110654,
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0.07905381,
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0.02365781,
0.4139212,
0.1467649,
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Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice. | Inhibition of TNFα protects the retina against diabetic-like changes in rodent models. The mechanism by which TNFα induces deleterious retinal changes is not known. Previously, we have shown that TNFα can inhibit normal insulin signal transduction, leading to increased apoptosis in both retinal endothelial cells (REC) ... | 25,138,272 | [
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0.1893592,
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Agar-supported cultivation of Halorubrum sp. SSR, and production of halocin C8 on the scale-up prototype Platotex. | Halorubrum sp. SSR was isolated from a solar saltern in Algeria. The strain exhibited a high antibiotic activity against the indicator strain Natronorubrum aibiense G23, and the bioactive compound showed thermal, acid and alkali stability. SSR was grown on agar-supported cultivation (AgSF) to compare yields and applica... | 25,138,277 | [
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0.08595641,
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0.4633565,
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... |
Dual role of Tlx3 as modulator of Prrxl1 transcription and phosphorylation. | The proper establishment of the dorsal root ganglion/spinal cord nociceptive circuitry depends on a group of homeodomain transcription factors that includes Prrxl1, Brn3a and Tlx3. By the use of epistatic analysis, it was suggested that Tlx3 and Brn3a, which highly co-localize with Prrxl1 in these tissues, are required... | 25,138,281 | [
0.5117639,
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0.03981669,
0.3904049,
0.3711999,
0.05845769,
... |
Enrichment options for African painted dogs (Lycaon pictus). | Best practices for carnivore enrichment encourage the diversity of species-typical behaviors, increased activity, and reduced stereotypic behavior; ideally considering the life-history and behavior of each species. African wild dogs (Lycaon pictus), or painted dogs, are social carnivores that have large home ranges and... | 25,138,282 | [
0.1079134,
0.3379983,
0.1081912,
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0.151632,
0.2732735,
0.01277953,
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0.332927,
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-0.1... |
Evaluation and validation of a serum bactericidal antibody assay for Haemophilus influenzae type b and the threshold of protection. | Prior to routine immunisation, Haemophilus influenzae serotype b (Hib) was a major cause of serious bacterial infections, particularly in young children. In the United Kingdom, introduction of the Hib conjugate vaccine into the national childhood immunisation schedule has led to a sustained decline in invasive Hib dise... | 25,138,290 | [
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0.1343395,
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0.3021169,
0.4439969,
0.1836931,
-0.0709... |
Temporary replacement of missing maxillary lateral incisors with orthodontic miniscrew implants in growing patients: rationale, clinical technique, and long-term results. | The missing maxillary lateral incisor in adolescent patients presents an orthodontic challenge. Historically, there have been three treatment options to address this clinical problem: (1) canine substitution, (2) tooth auto-transplantation, and (3) dental restoration. Unfortunately, these methods are not without limita... | 25,138,368 | [
-0.1799637,
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0.09907158,
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... |
Translational mini-screw implant research. | It is important to thoroughly test new materials as well as techniques when these innovations are to be utilized in the human clinical situation. Translational research fills this important niche. The purpose of translational research is to establish the continuity of evidence from the laboratory to the clinic and in s... | 25,138,369 | [
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0.1090639,
0.08119757,
0.09913421,
... |
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis. | Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serves as a helpfu... | 25,138,370 | [
0.007804193,
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0.2051949,
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0.09741809,
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-0.2685898,
... |
Early erythropoietin in post-diarrheal hemolytic uremic syndrome: a case-control study. | Although erythropoietin (EPO) deficiency has been reported in children with post-diarrheal hemolytic uremic syndrome (D + HUS), very limited clinical data on EPO use in this disease are currently available. In this case-control study we examined whether EPO administration would reduce the number of red blood cell (RBC)... | 25,138,373 | [
-0.3021793,
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0.1693707,
0.03487976,
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0.07326667,
-0.06771325,
0.03954582,
-0.0996... |
Hematologic findings predictive of bone marrow disease in dogs with multicentric large-cell lymphoma. | Evaluation of the bone marrow is needed for complete staging in dogs with multicentric large-cell lymphoma, but is often omitted in clinical practice. The objective was to determine if routine peripheral blood findings, including microscopic evaluation of blood smears, can predict the presence of bone marrow involvemen... | 25,138,384 | [
0.1774299,
0.1846281,
0.1536376,
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0.193352,
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0.2517038,
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0.08582468,
-0.1135653,
-0.02747249,
... |
Age-related pattern and monocyte-acquired haemozoin associated production of erythropoietin in children with severe malarial anaemia in Ghana. | Malaria continues to be a global health challenge, affecting more than half the world's population and causing approximately 660,000 deaths annually. The majority of malaria cases are caused by Plasmodium falciparum and occur in sub-Saharan Africa. One of the major complications asscociated with malaria is severe anaem... | 25,138,388 | [
-0.1079945,
0.02420396,
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0.1351079,
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0.117928,
0.02036594,
0.2698104,
0.47832,
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... |
[Citation analysis of research articles from Norwegian health enterprises, 2005-2011]. | The citation frequency of a publication is often interpreted as an expression of its scientific impact. Previous citation analyses of Norwegian medical research have either focused on universities and university hospitals or on subject areas at the national level. Such analyses have paid little attention to other healt... | 25,138,404 | [
-0.3078589,
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0.108162,
0.2616152,
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0.000155938,
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0.2360067,
0.1653556,
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Molecular imaging to predict ventricular arrhythmia in heart failure. | Ventricular tachycardia (VT) is a major cause of sudden cardiac death (SCD) in patients with heart failure (HF). Left ventricular ejection fraction (LVEF) and heart failure class according to the New York Heart association (NYHA) are in most common use to identify patients that may benefit from implantable cardioverter... | 25,138,427 | [
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0.2808428,
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Pathologic changes associated with suspected hypovitaminosis A in amphibians under managed care. | Vitamin A deficiency is a recently recognized nutritional disease in amphibians fed insect-based diets. The classic pathologic lesion that has been associated with hypovitaminosis A in amphibians is squamous metaplasia of the lingual and oral mucosa. In an attempt to further characterize the range of lesions that may b... | 25,138,440 | [
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0.2307118,
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0.2478407,
-0.3137047... |
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