title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Mobile teledermatology is a valid method to estimate prevalence of melanocytic naevi in children. | The prevalence of melanocytic naevi in children correlates with sun exposure and may serve as an objective population risk indicator of future melanoma incidence. The aim was to investigate if mobile teledermatology could offer a valid methodology compared with standard manual, face-to-face counting of naevi on the bac... | 25,138,480 | [
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The Equilibrium between Localized and Delocalized States of Thermochromic Semibullvalenes and Barbaralanes-Direct Observation of Transition States of Degenerate Cope Rearrangements. | The UV/Vis spectra of thermochromic semibullvalenes 1 and barbaralanes recorded at various temperatures yield enthalpy differences between the two degenerate classical structures 1 and 1' and the less stable species (1*) that absorb at long wavelengths. The latter species are interpreted in terms of higher, delocalized... | 25,138,495 | [
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Solvent Effects on the Equilibrium between Localized and Delocalized States of Thermochromic Semibullvalenes and Barbaralanes. | The position of the equilibrium between localized and delocalized states of thermochromic semibullvalenes and barbaralanes (see the Equation) depends strongly on the solvent. Dipolar aprotic solvents, particularly N,N'-dimethylpropylene urea, favor the delocalized, bishomoaromatic state (ΔH(0) =8 kJ mol(-1) (cyclohexan... | 25,138,496 | [
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An oxidation-labile traceless linker for solid-phase synthesis. | Traceless release of biaryls, acetylenes, alkenes, heterocycles, thioethers, and secondary amines from different solid supports can be achieved under very mild conditions by using a hydrazide group. This group, which is converted into an acyl diazene by oxidation and subsequently cleaved by a nucleophile (see scheme), ... | 25,138,498 | [
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Hexasupersilyl-triprismo-hexastannane (tBu3 Si)6 Sn6 -The First Molecular Tin Compound Containing a Sn6 Prism. | Dark violet hexastannane (tBu3 Si)6 Sn6 displays a new framework motif for molecular tin compounds, in which six Sn atoms are located at the corners of a trigonal prism. The compound can be synthesized according to Equation (a). R*=SitBu3 . | 25,138,509 | [
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A spreader-bar approach to molecular architecture: formation of stable artificial chemoreceptors. | The destructive influence of lateral diffusion on nanostructured monolayers can be prevented by using the spreader-bar technique. This approach allows the formation of stable artificial receptors for barbituric acid by lateral structuring of a dodecanethiol monolayer with molecular spreader-bars from thiobarbituric aci... | 25,138,511 | [
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A method for the selection of catalytic activity using phage display and proximity coupling. | Phage display has been used extensively for the selection of proteins with binding sites for ligands. Here, as illustrated with the example of DNA polymerase, the use of phage display for selection according to catalytic activity is described. Active enzymes are selected by binding of the reaction product P (see the sc... | 25,138,517 | [
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Alkyl migration aptitudes in the vinylidene-acetylene rearrangement and isotope effect in the vinylidene formation process from a deuterium-labeled cyclopropene. | The secret of the mechanism of vinylidene rearrangements has been unlocked by the use of specifically labeled cyclopropenes under mild thermal conditions (see the Equations). (13) C labeling gives the surprising 1,2-alkyl migratory aptitude sequence Et>iPr>Me. Deuterium labeling yields the first measurement of th... | 25,138,518 | [
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Molecular Recognition within a Self-Assembled Cylindrical Host. | A change in geometry is necessary on entry into the capsule: a supramolecular associate approximately 1.8 nm long (see schematic representation), which consists of two halves stabilized by hydrogen bonds, influences the intra- and intermolecular interactions of the guest molecules encapsulated. Thus tertiary amides and... | 25,138,521 | [
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Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3- mutant mice. | Spock3/Testican-3 is a nervous system-expressed heparan sulfate proteoglycan belonging to a subgroup of the BM-40/SPARC/osteonectin family, the role of which in brain development is unclear. Because Spock1, a member of the Spock family, inhibits their attachment to substrates and the neurite outgrowth of cultured neuro... | 25,138,526 | [
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Ubiquitin-activating enzyme is necessary for 17β-estradiol-induced breast cancer cell proliferation and migration. | The sex steroid hormone 17β-estradiol (E2) regulates breast cancer (BC) cell proliferation and migration through the activation of a plethora of signal transduction cascades (e.g., PI3K/AKT activation) starting after E2 binding to the estrogen receptor alpha (ERα). The activity of the ubiquitin (Ub)-system modulates ma... | 25,138,535 | [
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Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm. | PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting tha... | 25,138,534 | [
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Successful peripheral neuromodulation for phantom limb pain. | For decades, the heterogeneity of the amputee population and the complex interaction of biopsychosocial factors have confounded researchers' attempts to develop an effective treatment for phantom limb pain. Therefore, it remains difficult to treat, and affected patients often experience decreased quality of life, incre... | 25,138,543 | [
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Integrating Reiki and community-engaged scholarship: an interdisciplinary educational innovation. | To provide students with a meaningful holistic care experience while integrating community-engaged scholarship, students partnered with a Reiki-prepared faculty member within a nurse-managed community clinic to offer Reiki to the clients and participate in the evaluation of the effectiveness of the modality. This artic... | 25,138,568 | [
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Habitat differences influence genetic impacts of human land use on the American beech (Fagus grandifolia). | Natural reforestation after regional forest clearance is a globally common land-use sequence. The genetic recovery of tree populations in these recolonized forests may depend on the biogeographic setting of the landscape, for instance whether they are in the core or in the marginal part of the species' range. Using dat... | 25,138,571 | [
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Heart failure as a risk factor for diabetes mellitus. | Diabetes mellitus (DM) is a well-recognized risk factor for heart failure (HF). We hypothesized that HF also increases the risk for DM. We explored the hypothesis that HF is a risk factor for DM. The Cardiovascular Health Study was a prospective cohort study of cardiovascular risk in ambulatory older adults. We used a ... | 25,138,610 | [
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Leucocyte-rich and platelet-rich fibrin for the treatment of bisphosphonate-related osteonecrosis of the jaw: a prospective feasibility study. | Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessm... | 25,138,613 | [
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Evaluation of elastic bands for lower extremity resistance training in adults with and without musculo-skeletal pain. | Therapists commonly use elastic bands in resistance exercises during rehabilitation of smaller muscles, such as in the shoulder. However, the effectiveness has not yet been investigated for larger muscle groups. This study investigates muscle activity during lower extremity exercises. Electromyographic (EMG) activity o... | 25,138,624 | [
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Bone density among infants of gestational diabetic mothers and macrosomic neonates. | Decreased bone density has been found among infants of diabetic mothers and among large-for-gestational-age newborns. To evaluate which etiologies (physical or metabolic effect) have the greatest impact on neonatal bone density. A case-control study was conducted that included two study groups: one comprising 20 approp... | 25,138,627 | [
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Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys. | Cocaine addiction is characterized by alternating cycles of abstinence and relapse and loss of control of drug use despite severe negative life consequences associated with its abuse. The objective of the present study was to elucidate critical neural circuits involved in individual vulnerabilities to resumption of coc... | 25,138,647 | [
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Immunoglobulin G4-related paratesticular fibrous pseudotumor and retroperitoneal fibrosis: a case report. | A 46-year-old man with a past history of retroperitoneal fibrosis was admitted with an enlarged, hard right testis. The paratesticular lesion showed heterogeneous hypoechogenicity on ultrasonography, low signal intensity on T1- and T2-weighted magnetic resonance imaging (MRI), and lack of diffusion restriction on diffu... | 25,138,678 | [
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Hormonal regulation of the cytokine microenvironment in the mammary gland. | The mammary gland is a unique organ that undergoes hormone-driven developmental changes over the course of the ovarian cycle during adult life. Macrophages play a role in regulating cellular turnover in the mammary gland and may affect cancer susceptibility. However, the immune microenvironment that regulates macrophag... | 25,138,705 | [
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Detection of potentially skin sensitizing hydroperoxides of linalool in fragranced products. | On prolonged exposure to air, linalool can form sensitizing hydroperoxides. Positive hydroperoxide patch tests in dermatitis patients have frequently been reported, but their relevance has not been established. Owing to a lack of analytical methods and data, it is unclear from which sources the public might be exposed ... | 25,138,721 | [
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Comprehensive three-dimensional analysis of right-sided aortic arch with multiple vascular anomalies. | Right-sided aortic arch is a rare congenital defect usually diagnosed incidentally in adults; it is often asymptomatic unless aneurismal disease develops. In half the cases, an aberrant left subclavian artery arises from a Kommerell's diverticulum; in these cases, congenital heart anomaly is very rarely present. We rep... | 25,138,741 | [
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Selection considerations when using a 'standard optometrist' to evaluate clinical performance of other eye-care personnel. | Selection of a standard professional is crucial for assessing the clinical performance of other eye-care personnel. This paper describes the selection considerations and the clinical competency assessment of two optometrists required to select a 'standard optometrist' (SO) for evaluating the clinical performance of vis... | 25,138,747 | [
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A comparison of methods used to evaluate mobility performance in the visually impaired. | To compare three different approaches to measuring mobility performance when evaluating the visually impaired. 488 participants, including 192 glaucoma, 112 age-related macular degeneration, 91 diabetic retinopathy and 93 healthy volunteers, completed the Assessment of Disability Related to Vision (ADREV) mobility cour... | 25,138,757 | [
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Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study. | To compare the role of topically applied serum therapy with preservative-free artificial tear (AT) drops in patients with moderate to severe dry eye in Hansen's disease along with change in tear protein profile. 144 consecutive patients were randomly divided into three groups. After a baseline examination of clinical p... | 25,138,758 | [
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Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomised double-masked open-label clinical trial. | To assess the efficacy and safety of oral azithromycin compared with oral doxycycline in patients with meibomian gland dysfunction (MGD) who had failed to respond to prior conservative management. 110 patients (>12 years old) with MGD were randomly assigned to receive either oral 5-day azithromycin (500 mg on day 1 ... | 25,138,765 | [
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Governance practices and performance in US academic medical centers. | Recognition of the complex nature of modern health care delivery has led to interest in investigating the ways in which various factors, including governance structures and practices, influence health care quality. In this study, the chief executive officers (CEOs) of US academic medical centers were surveyed to elicit... | 25,138,782 | [
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Third-wave cognitive therapy versus mentalisation-based treatment for major depressive disorder: a randomised clinical trial. | To compare the benefits and harms of third-wave cognitive therapy versus mentalisation-based therapy in a small sample of depressed participants. The trial was conducted at an outpatient psychiatric clinic for non-psychotic patients in Roskilde, Denmark. 44 consecutive adult participants diagnosed with major depressive... | 25,138,802 | [
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Protocol for the RT Prepare Trial: a multiple-baseline study of radiation therapists delivering education and support to women with breast cancer who are referred for radiotherapy. | There is limited evidence to guide the preparation of patients for radiotherapy. This paper describes the protocol for an evaluation of a radiation therapist led education intervention delivered to patients with breast cancer in order to reduce psychological distress. A multiple-baseline study is being used. Usual care... | 25,138,815 | [
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Medication review saves nurses' time. | A project involving care home nurses that led to a significant reduction in unnecessary prescribing has saved around an hour a day of nursing time. | 25,138,843 | [
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Bariatric surgery. | Essential facts: Type 2 diabetes is linked closely to obesity. Bariatric surgery can lead to dramatic improvements in the management of the condition, according to the National Institute for Health and Care Excellence (NICE). There are two main types of bariatric surgery. A gastric band procedure uses a band to reduce ... | 25,138,853 | [
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Help for overseas nurses unable to obtain supervised placements. | Nurses from outside the European Economic Area looking to work in the UK will no longer have to complete supervised practice placements (News August 6). | 25,138,869 | [
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It is just a matter of application. | The Camilla Cavendish review of support worker education was clear that improving the quality of healthcare assistant (HCA) learning is central to delivering safe and effective care. Well trained staff should treat patients well, so the point of education and training must be to support HCAs to deliver effective care. ... | 25,138,890 | [
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Enabling LiTFSI-based electrolytes for safer lithium-ion batteries by using linear fluorinated carbonates as (Co)solvent. | In this Full Paper we show that the use of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) as conducting salt in commercial lithium-ion batteries is made possible by introducing fluorinated linear carbonates as electrolyte (co)solvents. Electrolyte compositions based on LiTFSI and fluorinated carbonates were charac... | 25,138,922 | [
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[Image-enhanced endoscopy and magnifying endoscopy for esophageal cancer]. | Image diagnoses for esophageal cancer are progressing. With regard to endoscopic examination, chrome endoscopy using iodine have been performed so far to identify the range of lesion and to detect multiple primary cancers. In addition to that, endoscopic ultrasonography is used to diagnose the depth of tumor invasion a... | 25,138,953 | [
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Compressed-sensing-based fluorescence molecular tomographic image reconstruction with grouped sources. | Although the quality of reconstructed results can be improved with the increment of the number of measurements, the scale of the matrices involved in the reconstruction of fluorescence molecular tomography (FMT) will become larger, which leads to the poor efficiency of the process of tomographic image reconstruction. I... | 25,138,956 | [
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Oxygen uptake at different intensities and sub-techniques predicts sprint performance in elite male cross-country skiers. | To investigate the relationship between sprint-prologue performance (using the classical technique) and the oxygen uptake at the lactate threshold (VO₂obla), maximal oxygen uptake (VO₂max), and mean oxygen uptake during double poling (VO₂dp). Eight elite male cross-country skiers [age 24.8 ± 4.8 years, (mean ± SD)] com... | 25,138,966 | [
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Epidemiology and outcome of invasive pneumococcal disease among adults in Belgium, 2009-2011. | This epidemiological study examined morbidity and case fatality of invasive pneumococcal disease (IPD) in adults in Belgium as well as distribution and antibiotic susceptibility of Streptococcus pneumoniae serotypes.Adults hospitalised with microbiologically proven IPD were prospectively enrolled. The study started in ... | 25,138,972 | [
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Early-onset Alzheimer's disease in two Iranian families: a genetic study. | Early-onset Alzheimer's disease (EOAD) represents less than 5% of all AD cases. Autosomal dominant EOAD has been defined as the occurrence of at least three cases in three generations. Mutations in the amyloid precursor protein (APP), presenilin-1 and presenilin-2 genes have been recognized to be the cause of EOAD. We ... | 25,138,979 | [
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PlasmaKinetic™ versus cold knife internal urethrotomy in terms of recurrence rates: a prospective randomized study. | To evaluate the efficacy and outcomes of PlasmaKinetic™ urethrotomy against cold knife direct vision internal urethrotomy in terms of recurrence rates. A total of 136 male patients with urethral strictures were enrolled into the study. The patients were allocated to cold knife or PlasmaKinetic urethrotomy groups sequen... | 25,138,990 | [
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Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population. | Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population. We evaluated the association... | 25,138,993 | [
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Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling. | Na-ASP-2 is an efficacious hookworm vaccine antigen. However, despite elucidation of its crystal structure and studies addressing its immunobiology, the function of Na-ASP-2 has remained elusive. We probed a 9000-protein human proteome microarray with Na-ASP-2 and showed binding to CD79A, a component of the B-cell anti... | 25,139,017 | [
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Basis of virulence in a Panton-Valentine leukocidin-negative community-associated methicillin-resistant Staphylococcus aureus strain. | Community-associated (CA) infections with methicillin-resistant Staphylococcus aureus (MRSA) are on a global rise. However, analysis of virulence characteristics has been limited almost exclusively to the US endemic strain USA300. CA-MRSA strains that do not produce Panton-Valentine leukocidin (PVL) have not been inves... | 25,139,021 | [
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MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells. | MicroRNAs (miRNAs) have gained much attention due to their critical roles in diverse biological events, including tumorigenesis. In this study, we demonstrate that miR-136 is down-regulated in two cohorts of patients with glioma. Furthermore, the low-level expression of miR-136 is significantly associated with a more a... | 25,139,024 | [
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Sequencing and de novo assembly of the red cusk-eel (Genypterus chilensis) transcriptome. | The red cusk-eel (Genypterus chilensis) is an endemic fish species distributed along the coasts of the Eastern South Pacific. Biological studies on this fish are scarce, and genomic information for G. chilensis is practically non-existent. Thus, transcriptome information for this species is an essential resource that w... | 25,139,027 | [
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Investigation on bacterial community and diversity in the multilayer aquifer-aquitard system of the Pearl River Delta, China. | Bacteria play an important role in groundwater chemistry. The groundwater resource in the Pearl River Delta (PRD) is responsible for 50 million people's water requirement. High amount of ammonium, arsenic and methane had been reported in groundwater of the PRD, which was considered as the result of intensive bacterial ... | 25,139,031 | [
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Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice. | We recently identified BIG3 as a negative regulator of insulin granule biogenesis and reported increased insulin secretion in BIG3-knockout (BKO) mice. To pinpoint the site of action for BIG3, we investigated whether BIG3 regulates quantal insulin granule exocytosis. We established an assay to detect insulin granule ex... | 25,139,048 | [
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Liver resection for colorectal metastases: results and prognostic factors with 10-year follow-up. | Actual 5-year survival rates after resection of colorectal liver metastases (CLM) are 25-45%, whereas 10-year survival rates are extrapolated from survival curves. Few studies have reported long-term survivors with 10 years of actual follow-up. Therefore, no recurrences occurring after 10-plus years have been reported.... | 25,139,067 | [
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Increase of pertussis incidence in 2010 to 2012 after 12 years of low circulation in Spain. | In Spain, whole cell pertussis vaccination started in 1975, with three doses before the age of 6-7 months. Doses at 15-18 months and 4-6 years were introduced in 1996 and 2001, respectively. Spain switched to an acellular vaccine in 2005. From 1998 to 2009, pertussis incidence rates remained ≤1.5 cases/100,000 inhabita... | 25,139,074 | [
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Reduction of α-dystroglycan expression is correlated with poor prognosis in glioma. | Dystroglycan (DG), a multifunctional protein dimer of non-covalently linked α and β subunits, is best known as an adhesion and transduction molecule linking the cytoskeleton and intracellular signaling pathways to extracellular matrix proteins. Loss of DG binding, possibly by degradation or disturbed glycosylation, has... | 25,139,094 | [
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Investigation of the MICs of fidaxomicin and other antibiotics against Hungarian Clostridium difficile isolates. | The aim of this study was to investigate in vitro activities of fidaxomicin and other antibiotics against 188 Clostridium difficile strains collected from different centers of Hungary. C. difficile isolates showed minimum inhibitory concentration (MIC) range for fidaxomicin of ≤0.008-0.5 mg/L, with a MIC90 of 0.125 mg/... | 25,139,122 | [
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Ketamine peritonsillar infiltration during tonsillectomy in pediatric patients: An updated meta-analysis. | Peri-operative ketamine peritonsillar infiltration in children can reduce the incidence of postoperative nausea and vomiting (PONV), but its postoperative analgesic time is short. A previous meta-analysis in 2011 was inconclusive due to insufficient data. Consequently, we updated the meta-analysis to verify the role of... | 25,139,134 | [
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Antimicrobial light-activated materials: towards application for food and environmental safety. | To produce light-activated antimicrobial materials composed of the photodynamic dye phloxine B incorporated into paper or cellulose membranes and to investigate ability of these materials to decrease bacterial loads on their surfaces as well as on food surfaces that were in contact with these materials under illuminati... | 25,139,147 | [
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... |
Effect of DOCA/salt hypertension on CRF expression in the amygdala and the autonomic stress response in conscious rats. | The effects of DOCA/salt treatment on amygdala-area CRF gene expression and the autonomic response to air jet stress (AJS) were evaluated in conscious male Sprague Dawley (SD) rats. Fifteen days of DOCA/salt treatment significantly increased resting arterial pressure (AP), decreased resting heart rate (HR) and signific... | 25,139,171 | [
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Photoinduced energy transfer from poly(N-vinylcarbazole) to tricarbonylchloro-(2,2'-bipyridyl)rhenium(I). | This work investigates the photoinduced energy transfer from poly(N-vinylcarbazole) (PVK), as a donor material, to fac-(2,2'-bipyridyl)Re(CO)3Cl, as a catalyst acceptor, for its potential application towards CO2 reduction. Photoluminescence quenching experiments reveal dynamic quenching through resonance energy transfe... | 25,139,180 | [
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The effect of protein PEGylation on physical stability in liquid formulation. | The presence of micron aggregates in protein formulations has recently attracted increased interest from regulatory authorities, industry, and academia because of the potential undesired side effects of their presence. In this study, we characterized the micron aggregate formation of hen egg-white lysozyme (Lyz) and it... | 25,139,193 | [
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Ozone and daily mortality rate in 21 cities of East Asia: how does season modify the association? | Previous studies in East Asia have revealed that the short-term associations between tropospheric ozone and daily mortality rate were strongest in winter, which is opposite to the findings in North America and Western Europe. Therefore, we investigated the season-varying association between ozone and daily mortality ra... | 25,139,207 | [
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Cardiac involvement in chronic progressive external ophthalmoplegia. | Myocardial involvement has not been extensively investigated in mitochondrial myopathies. The aim of the study was to assess the myocardial morpho-functional changes in patients with chronic progressive external ophthalmoplegia (PEO). Twenty patients with PEO and 20 controls underwent standard echocardiography with tis... | 25,139,213 | [
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Bacterial role in pine wilt disease development - review and future perspectives. | Mutualistic and beneficial relationships between nematodes and bacteria are highly present in nature, mostly occurring because of nutritional dependence and pathogen protection, and intrinsically related with the environment, the ecological conditions and the nematode life stages. Thirty-four years have passed since th... | 25,139,220 | [
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Investigation of age-related differences in an adapted Hayling task. | The Hayling task is traditionally used to assess activation and inhibitory processes efficiency among various populations, such as elderly adults. However, the classical design of the task may also involve the influence of strategy use and efficiency of sentence processing in the possible differences between individual... | 25,139,228 | [
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Pressure mat analysis of naturally occurring lameness in young pigs after weaning. | Lameness is a common problem in modern swine husbandry. It causes welfare problems in affected pigs as well as financial problems for farmers. To minimize these negative consequences of lameness, new treatment and prevention strategies need to be developed and validated using objective and quantitative measurement tech... | 25,139,245 | [
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Comparative evaluation of molar distalization therapy with erupted second molar: Segmented versus Quad Pendulum appliance. | There are controversial opinions about the effect of erupted second molars on distalization of the first molars. Most of the distalizing devices are anchored on the first molars, without including second molars; so, differences between sequentially distalize maxillary molars (second molar followed by the first molar) o... | 25,139,288 | [
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NK cells kill mycobacteria directly by releasing perforin and granulysin. | Although the mechanisms underlying the cytotoxic effect of NK cells on tumor cells and intracellular bacteria have been studied extensively, it remains unclear how these cells kill extracellular bacterial pathogens. In this study, we examine how human NK cells kill Mycobacterium kansasii and M.tb. The underlying mechan... | 25,139,289 | [
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Preoperative smoking cessation can reduce postoperative complications in gastric cancer surgery. | Despite the close link between cigarette smoking and the development of gastric cancer, little is known about the effects of cigarette smoking on surgical outcomes after gastric cancer surgery. The aim of this study was to investigate whether preoperative smoking status and the duration of smoking cessation were associ... | 25,139,298 | [
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Canine progenitor epidermal keratinocytes express various inflammatory markers, including interleukin-8 and CD40, which are affected by certain antibiotics. | Bacterial skin infections are common in dogs and humans. Keratinocytes have phenotypic features of nonprofessional antigen-presenting cells and express various cytokines. However, little is known about the effects of antibiotics on inflammatory markers in canine keratinocytes. To investigate inflammatory markers in can... | 25,139,312 | [
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Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton. | Following invasion of human red blood cells (RBCs) by the malaria parasite, Plasmodium falciparum, a remarkable process of remodeling occurs in the host cell mediated by trafficking of several hundred effector proteins to the RBC compartment. The exported virulence protein, P falciparum erythrocyte membrane protein 1 (... | 25,139,348 | [
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The dynamic impact of repeated stress on the hippocampal spatial map. | Stress alters the function of many physiological processes throughout the body, including in the brain. A neural circuit particularly vulnerable to the effects of stress is the hippocampus, a key component of the episodic and spatial memory system in both humans and rodents. Earlier studies have provided snapshots of m... | 25,139,366 | [
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Burden of carbapenem-resistant organisms in the Frankfurt/Main Metropolitan Area in Germany 2012/2013 - first results and experiences after the introduction of legally mandated reporting. | The federal state of Hesse, Germany, introduced a laboratory-based reporting scheme for carbapenem-resistant organisms (CROs). The results of the first year of mandated reporting of CROs from April 2012 through March 2013 to the Public Health Authority of Frankfurt/Main, responsible for a population of 700,000 inhabita... | 25,139,410 | [
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PTEN loss-mediated Akt activation increases the properties of cancer stem-like cell populations in prostate cancer. | To demonstrate that the PTEN/PI3K/Akt/NF-κB pathway plays an important role in regulating the prostate cancer stem-like cell population by upregulating ABCG2. Targeted PTEN knockdown in human prostate DU145 and 22Rv1 cells using a small interfering RNA were confirmed by immunoblot analysis using antibodies of PTEN, pho... | 25,139,413 | [
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Streptococcus oriloxodontae sp. nov., isolated from the oral cavities of elephants. | Two strains were isolated from oral cavity samples of healthy elephants. The isolates were Gram-positive, catalase-negative, coccus-shaped organisms that were tentatively identified as a streptococcal species based on the results of biochemical tests. Comparative 16S rRNA gene sequence analysis suggested classification... | 25,139,416 | [
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Taxonomy and phylogeny of two species of the genus Deviata (Protista, Ciliophora) from China, with description of a new soil form, Deviata parabacilliformis sp. nov. | The morphology and morphogenesis of a soil hypotrichous ciliate, Deviata parabacilliformis sp. nov., isolated from northern China, were investigated. D. parabacilliformis measures about 75-210 × 25-60 µm in vivo, with an elongate and flexible body. It possesses one right marginal row, two to four left marginal rows and... | 25,139,418 | [
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Is the Sequential Laser Technique for Twin-to-Twin Transfusion Syndrome Truly Superior to the Standard Selective Technique? A Meta-Analysis. | To investigate the efficacy of sequential laser coagulation in the treatment of twin-to-twin transfusion syndrome (TTTS). MEDLINE, EMBASE and the Cochrane Library were systematically searched for comparative studies on the efficacy of sequential versus standard selective laser coagulation for TTTS. The primary outcome ... | 25,139,419 | [
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Ophthalmic imaging. | The last two decades have seen a revolution in ophthalmic imaging. In this review we present an overview of the breadth of ophthalmic imaging modalities in use today and describe how the role of ophthalmic imaging has changed from documenting abnormalities visible on clinical examination to the detection of clinically ... | 25,139,430 | [
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Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A. | Total synthesis of cryptocin, a fungus metabolite, was achieved based on the biosynthetic hypothesis. A variety of derivatives of cryptocin, equisetin and fusarisetin A were prepared, wherein the racemization of C-3 and diastereoselectivity of C-5 were investigated. We further examined their inhibitory effects on breas... | 25,139,438 | [
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Boron-double-ring sheet, fullerene, and nanotubes: potential hydrogen storage materials. | Similar to carbon-based graphene, fullerenes and carbon nanotubes, boron atoms can form sheets, fullerenes, and nanotubes. Here we investigate several of these novel boron structures all based on the boron double ring within the framework of density functional theory. The boron sheet is found to be metallic and flat in... | 25,139,442 | [
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Prognostic value of midregional pro-A-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide in patients with stable coronary heart disease followed over 8 years. | Pathophysiological studies suggest that A-type natriuretic peptides (ANPs) might provide valuable information beyond B-type natriuretic peptides (BNPs) about cardiac dysfunction in patients with coronary heart disease (CHD). We aimed to assess the predictive value of midregional pro-A-type natriuretic peptide (MR-proAN... | 25,139,456 | [
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Utilization of Zwitterion-based solutions to dissect the relative effects of solution pH and ionic strength on the aggregation behavior and conformational stability of a fusion protein. | Solution pH and ionic strength (I) have complex effects on protein stability. We developed an experimental approach based on exploitation of the zwitterionic characteristic of amino acid molecules to probe the relative contribution from each. A variety of types of amino acid solutions were adopted to investigate the ef... | 25,139,470 | [
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The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise. | Hemodialysis is known to decrease blood glucose concentration (BGC), insulin, and methylglyoxal levels. However, the effects of decreases in these factors on the increase in post-hemodialysis BGC remain unknown. This study identifies the effects of hemodialysis-induced changes in concentrations of these elements on pos... | 25,139,482 | [
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1,25-Vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathway. | Cardiovascular disease (CVD) remains the leading cause of death worldwide. Low levels of vitamin D are associated with high risk of myocardial infarction, even after controlling for factors associated with coronary artery disease. A growing body of evidence indicates that vitamin D plays an important role in CVD-relate... | 25,139,490 | [
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What forgetting tells us about remembering: the influence of top-down control on hemispheric asymmetries in verbal memory. | It has been suggested that left hemisphere (LH) advantages in verbal processing is due to superior top-down control of verbal information. It is not clear how top-down mechanisms affect the encoding and retrieval of verbal information from hemispheric memory and whether they only influence activation or also encompass ... | 25,139,497 | [
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0.1984445,
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Unexpected roles for ancient proteins: flavone 8-hydroxylase in sweet basil trichomes is a Rieske-type, PAO-family oxygenase. | Most elucidated hydroxylations in plant secondary metabolism are catalyzed by oxoglutarate- or cytochrome P450-dependent oxygenases. Numerous hydroxylations still evade clarification, suggesting that they might be performed by alternative enzyme types. Here, we report the identification of the flavone 8-hydroxylase (F8... | 25,139,498 | [
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Antihypertensive medication exposure and cardiovascular outcomes in hemodialysis patients. | Our understanding of the effectiveness of cardioprotective medications in maintenance dialysis patients is based upon drug exposures assessed at a single point in time. We employed a novel, time-dependent approach to modeling medication use over time to examine outcomes in a large national cohort. We linked Medicaid pr... | 25,139,551 | [
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Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors. | A new series of 2-(1,3,4-thiadiazolyl- or 4-methyl-thiazolyl)thio-6-substituted-quinazolin-4-one analogs was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 29, 34, and 39 proved to be the most active DHFR inhibitors with IC50 values range of 0... | 25,139,568 | [
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0... |
Synthesis, biological evaluation and SAR analysis of O-alkylated analogs of quercetin for anticancer. | O-Alkylated quercetin analogs were synthesized and their anticancer activities were assessed by a high-throughout screening (HTS) method. The structure-activity relationships (SAR) showed that introduction of long alkyl chain such as propyl group at the C-3 OH position or short alkyl chain such as ethyl group at the C-... | 25,139,569 | [
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... |
Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington's disease gene carriers: a three-year follow-up study. | We previously demonstrated that in the premanifest stage of Huntington's disease (preHD), a reduced functional connectivity exists compared to healthy controls. In the current study, we look at possible changes in functional connectivity occurring longitudinally over a period of 3 years, with the aim of assessing the p... | 25,139,578 | [
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Evidence for efficacy of acute treatment of episodic tension-type headache: methodological critique of randomised trials for oral treatments. | The International Headache Society (IHS) provides guidance on the conduct of trials for acute treatment of episodic tension-type headache (TTH), a common disorder with considerable disability. Electronic and other searches identified randomised, double-blind trials of oral drugs treating episodic TTH with moderate or s... | 25,139,586 | [
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Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity. | Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gene... | 25,139,590 | [
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Downregulation of endogenous STAT3 augments tumoricidal activity of interleukin 15 activated dendritic cell against lymphoma and leukemia via TRAIL. | Effector functions in tumor resistance by dendritic cells (DCs) are less well characterized. In this study, we describe that the murine DCs upon stimulation with recombinant IL-15 in vitro or in vivo, expresses TNF superfamily member TRAIL which mediates cytotoxicity and growth inhibition against a murine lymphoma call... | 25,139,620 | [
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... |
Cerebellar control of gait and interlimb coordination. | Synaptic and intrinsic processing in Purkinje cells, interneurons and granule cells of the cerebellar cortex have been shown to underlie various relatively simple, single-joint, reflex types of motor learning, including eyeblink conditioning and adaptation of the vestibulo-ocular reflex. However, to what extent these p... | 25,139,623 | [
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0.179956... |
Standard of care and future pharmacological treatment options for malignant glioma: an urgent need for screening and identification of novel tumor-specific antigens. | Malignant gliomas (MGs) represent the most common primary brain tumors in adults, the most deadly of which is grade IV glioblastoma. Patients with glioblastoma undergoing current standard-of-care therapy have a median survival of 12 - 15 months. Over the past 25 years, there have been modest advancements in the treatme... | 25,139,628 | [
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0.06501384,
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... |
Outcomes in acute heart failure: 30-day readmission versus death. | For patients hospitalized with acute heart failure, health policy initiatives in the USA have drawn attention to 30-day mortality and readmission. Confusion around definitions, populations, and thus reported rates for these two outcomes is common. Among Medicare fee-for-service patients hospitalized with heart failure,... | 25,139,630 | [
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0.02300017,
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... |
Predictors of diabetes foot complications among patients with diabetes in Saudi Arabia. | To identify risk factors and clinical biomarkers of prevalent diabetes foot complications, including foot ulcers, gangrene and amputations among patients with diabetes in Jeddah, Saudi Arabia. 598 diabetes patients from Jeddah participated in the current study. Patients were considered to have diabetes foot complicatio... | 25,139,632 | [
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0.1464033,
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0.1293523,
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A review of the economic tools for assessing new medical devices. | Whereas the economic evaluation of pharmaceuticals is an established practice within international health technology assessment (HTA) and is often produced with the support of comprehensive methodological guidance, the equivalent procedure for medical devices is less developed. Medical devices, including diagnostic pro... | 25,139,635 | [
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0.3587632,
0.1142082,
-0.2650171,
... |
Characterization of a mutant glucose isomerase from Thermoanaerobacterium saccharolyticum. | A series of site-directed mutant glucose isomerase at tryptophan 139 from Thermoanaerobacterium saccharolyticum strain B6A were purified to gel electrophoretic homogeneity, and the biochemical properties were determined. W139F mutation is the most efficient mutant derivative with a tenfold increase in its catalytic eff... | 25,139,657 | [
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0.2427474,
0.2981524,
0.6393277,
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Beneficial effect of cilostazol-mediated neuronal repair following trimethyltin-induced neuronal loss in the dentate gyrus. | Cilostazol acts as an antiplatelet agent and has other pleiotropic effects based on phosphodiesterase-3-dependent mechanisms. We evaluated whether cilostazol would have a beneficial effect on neuronal repair following hippocampal neuronal damage by using a mouse model of trimethyltin (TMT)-induced neuronal loss/self-re... | 25,139,675 | [
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... |
Understanding the polar mechanism of the ene reaction. A DFT study. | The molecular mechanism of ene reactions has been characterised by DFT methods at the MPWB1K/6-311G(d,p) level of theory. Most reactions take place along a two-stage one-step mechanism in which the C-C bond formation takes place before the hydrogen transfer process. A very good correlation between the polar character o... | 25,139,695 | [
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0.2780463,
0.08658008,
0.2209102,
-0.083477... |
Prospective randomized trial comparing open reduction and internal fixation with minimally invasive reduction and percutaneous fixation in managing displaced intra-articular calcaneal fractures. | Managing displaced intra-articular calcaneal fractures remains controversial. A prospective randomised trial was undertaken to compare open reduction and internal fixation (ORIF) with minimally invasive reduction and percutaneous fixation (MIRPF). Forty-five displaced intra-articular calcaneal fractures were randomised... | 25,139,716 | [
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-0.09685... |
Rationale and design of REWARD (revving-up exercise for sustained weight loss by altering neurological reward and drive): a randomized trial in obese endometrial cancer survivors. | Obesity is a leading risk factor for endometrial cancer (EC), particularly Type I forms, which are increasing in the U.S. Although death rates from most cancers have been decreasing, overall mortality in EC is increasing in the U.S. EC survivors' poor fitness combined with their surgical treatments may make weight loss... | 25,139,726 | [
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0.04292785,
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0.1970655,
-0.13067... |
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