text stringlengths 74 7.86k | meta dict |
|---|---|
The epithelial-mesenchymal transition (EMT) is characterized by the loss of cell-cell adhesion and cell polarity in epithelial cells and the acquisition of motile and invasive properties. While essential for development, the EMT is one mechanism by which tumors can acquire the capability to undergo tissue invasion and ... | {
"pile_set_name": "NIH ExPorter"
} |
[unreadable] The specific aim of this application is to help the UPR for repair, renovation, and modernization of its unique animal research resource (ARC) at the CS facility of the CPRC. The CPRC is an unrivaled national and international research resource for comparative studies in the biomedical and behavioral scien... | {
"pile_set_name": "NIH ExPorter"
} |
EXCEED THE SPACE PROVIDED. The proposed research is a continued study of mobile introns in bacteria. The mobile group I and group II introns are both self-splicing, but their RNA-splicing and DNA-mobility pathways are distinct. In each case, the intron typically transfers to an allelic intron-less site, in a homingproc... | {
"pile_set_name": "NIH ExPorter"
} |
A number of recent studies suggest that cognitive processes rely on spatial and temporal patterns of activity in extended neural networks. Optical imaging techniques can provide information on a microscopic level about the individual and collective behavior of cells involved in these processes. We propose to develop an... | {
"pile_set_name": "NIH ExPorter"
} |
Complex developmental processes that define organ morphology and cellular differentiation appear to be governed by only several signal transduction pathways, suggesting the likelihood of extensive interactions among those pathways. However, the mechanisms that coordinate the activity of different signaling cascades inv... | {
"pile_set_name": "NIH ExPorter"
} |
DESCRIPTION (Directly taken from the application) Polycystic kidney disease (PKD) is characterized by proliferating epithelial cells, alterations in basement membrane composition, and aberrant localization of cell surface proteins. These cellular properties are consistent with a reversion of the renal epithelial cell t... | {
"pile_set_name": "NIH ExPorter"
} |
The object of the proposed investigation is to gain additional insight into the molecular events and regulatory implications in messenger-RNA metabolism in cultured mammalian cells. Human (HeLa S3) cells infected by and rat embryo cells transformed by adenovirus will be employed in these investigations. In the lytic in... | {
"pile_set_name": "NIH ExPorter"
} |
Molecular Core Abstract: Dr. Harris will direct the Molecular Core and a staff of two full-time scientists. This essential Core will service the Program Project entitled "Critical Interactions of APOBECSs: Molecular Approaches to Novel HiV Therapies" by producing plasmid DNA constructs for APOBECS and Vif protein expre... | {
"pile_set_name": "NIH ExPorter"
} |
The consequences of alcohol abuse on the American public are profound, both in terms of individual well-being and impact on the family structure, as well as the enormous cost to society in terms of lost productivity and associated health care expenses. Despite increasing efforts, our understanding of the neurobiologica... | {
"pile_set_name": "NIH ExPorter"
} |
We have constructed (and continue to develop) a laser-based facility for time-resolved fluorescence spectroscopy of biomolecules. This facility provides rapid collection and analysis of luminescence data related to macromolecular size, flexibility, folding and structural fluctuations. Our time-correlated laser fluorome... | {
"pile_set_name": "NIH ExPorter"
} |
G Proteins participate in the transduction of cellular signals by cycling between an active conformation (complexed with GTP) D and an inactive conformation (complexed with GDP). The ras proteins are guanine nucleotide binding proteins believed to participate in the transduction of proliferative signals, although their... | {
"pile_set_name": "NIH ExPorter"
} |
OVERALL DESCRIPTION: This application continues and amplifies the work already undergoing at the Center. The overall goal of the MU proposal is to foster interdisciplinary research that will enable the systematic evaluation of the safety and efficacy of botanicals. The PI's of the current proposal have already establis... | {
"pile_set_name": "NIH ExPorter"
} |
DESCRIPTION (provided by investigator): Fluorogenic minor groove binder (MGB) probes containing an MGB-quencher at the 5'-end and a fluorophore at the 3'-end have been recently reported. These probes fluoresce on hybridization to the complementary targets. The 5'-MGB-quencher group prevents 5' - nuclease digestion by T... | {
"pile_set_name": "NIH ExPorter"
} |
Lung cancer is the leading cause of cancer related mortality in both men and women and remains a major health issue. More than 162,000 individuals will die from lung cancer in the coming year, more than breast, prostate and colon cancer combined. The majority of lung cancer cases is attributable to tobacco smoking and ... | {
"pile_set_name": "NIH ExPorter"
} |
We have also completed the first characterization of the active site of NiSOD from Streptomyces seoulensis. This study reveals that Ni site is bound to thiolate donors, like other Ni redox enzymes but unlike any previously characterized SOD. Examination of oxidized and reduced samples reveal a coordination number chang... | {
"pile_set_name": "NIH ExPorter"
} |
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which... | {
"pile_set_name": "NIH ExPorter"
} |
This research is aimed at the elucidation of the biological function and genetic control of the polydisperse circular DNA complement of Bacillus megaterium. The specific objectives involve: (1) the characterization of the mode of production of these elements; (2) the determination of their physiological function in the... | {
"pile_set_name": "NIH ExPorter"
} |
In cancer, normal epigenetic silencing and cytosine methylation are disrupted. Dietary intake of methyl donors can directly affect epigenetic mechanisms through cytosine methylation. Our longterm goal is to understand how the risk of human disease, cancer in particular, is affected by epigenetics and diet. We use A10-v... | {
"pile_set_name": "NIH ExPorter"
} |
The airway epithelium represents the first line of defense for the lungs against inhaled-pollutants and infectious agents. Injury to the airway epithelium occurs during mechanical ventilation and in inflammatory diseases such as asthma. Movement of air into and out of the lungs during respiration causes wide variations... | {
"pile_set_name": "NIH ExPorter"
} |
This is a multi-center study to determine if Selegiline and/or Tocopheral will slow the progression of Alzheimer's disease. It is a double blind, multi-center, placebo controlled study. | {
"pile_set_name": "NIH ExPorter"
} |
The long-term goals of this work include developing methods to image the stress response in the brains of experimental animals and humans, and to develop methods of manipulating the stress response in order to protect the brain against ischemia and other injuries. Experiments will determine whether local protein synthe... | {
"pile_set_name": "NIH ExPorter"
} |
The functional nature of the projection from the frontal eye field to the brain stem has been studied in the rhesus monkey. Like the frontotectal projection, the frontopontine projection contains cells which discharge in association with eye movements or visual fixation, but not cells which have exclusive peripheral vi... | {
"pile_set_name": "NIH ExPorter"
} |
Streptococcus pneumoniae (the pneumococus) ranks among the five leading causes of infectious death worldwide. This single species accounts for a large proportion of respiratory tract (pneumonia, otitis media) and invasive (sepsis, meningitis) bacterial diseases. The development of efficacious conjugate vaccines for chi... | {
"pile_set_name": "NIH ExPorter"
} |
Experimental autoimmune thyroiditis in mice is a very useful model of autoimmune disease since it shows the strongest genetic control by gene(s) within the major histocompatibility complex so far described for such a disease. Preliminary experiments suggested that monoclonal anti-Ia antibodies given before immunization... | {
"pile_set_name": "NIH ExPorter"
} |
This application for a KO1 Career Development Award seeks five years of support for education and research activities that will prepare Dr. Justeen Hyde to examine the consequences of child abuse and neglect among adolescents in the foster care system in Los Angeles. Previous research has identified children in foster ... | {
"pile_set_name": "NIH ExPorter"
} |
To determine whether phlebotomy to an iron depleted state improves response of chronic hepatitis C infection to alpha-interferon therapy in patients who have previously failed such therapy. A secondary objective will be to correlate iron reduction therapy via phlebotomy with hepatic iron concentration. The primary effi... | {
"pile_set_name": "NIH ExPorter"
} |
This application seeks support for Pediatric Oncology Group activities by Southwestern Medical School. Since 1981 our institution has grown to become the Group's third or fourth largest member, among 40 participating institutions, with regard to patients enrolled on therapeutic studies. Moreover, investigators from our... | {
"pile_set_name": "NIH ExPorter"
} |
Amyloid b-peptide (Ab), the major molecular component of the cerebral amyloid plaques, appears to play a central role in the neuropathology of Alzheimer's disease (AD). Compounds that prevent the formation of Ab aggregates or that selectively destroy these aggregates are attractive candidates for the development of the... | {
"pile_set_name": "NIH ExPorter"
} |
In order to understand how a pathogenic change in a gene causes disease, it is necessary to recognize how pathogenic mutations could affect a protein structure-function, protein-protein interactions in protein networks and how these changes could be associated with clinical parameters describing the disease phenotype. ... | {
"pile_set_name": "NIH ExPorter"
} |
The Illinois Prevention Research Center (IPRC) of the University of Illinois at Chicago has a primary mission to reduce health disparities through behavior change approaches by conducting health promotion and disease prevention research across the lifespan, translating research into practice and measuring the real-worl... | {
"pile_set_name": "NIH ExPorter"
} |
Mature B cell lymphomas are a diverse set of diseases which share the property of having failed to complete the differentiation process into plasma cells or undergo apoptosis. PRDI-BF1 and its murine homologue Blimp-1 are transcriptional repressors and act as a molecular switch to commit activated B cells to become non... | {
"pile_set_name": "NIH ExPorter"
} |
Our objectives are to promote excellence in biomedical research through development and maintainance of high quality animal resources. To meet these objectives we propose three major projects within the animal resources program: 1. Renovate animal surgery facilities to provide a suitable environment for recovery surger... | {
"pile_set_name": "NIH ExPorter"
} |
In the course of studying inflammatory muscle diseases (polymyositis, dermatomyositis, and related diseases), we have encountered patients with many other muscle diseases. We have studied patients with two genetic metabolic myopathies in detail: phosphofructokinase (PFK) deficiency, and acid maltase (acid alpha-glucosi... | {
"pile_set_name": "NIH ExPorter"
} |
Currently, the standard of care for cancer therapy has limited specificity to only tumor tissue, and can cause devastating side effects. Cancer vaccines utilize the immune system to generate a sustainable and specific anti-tumor response, providing a promising means to improve cancer therapy. However, delivery of vacci... | {
"pile_set_name": "NIH ExPorter"
} |
An understanding of the relationship between malarial parasites and their hosts will ultimately aid in developing vaccine strategies. Malarial parasites release heat-stable soluble antigens into the sera of human infected with Plasmodium falciparum. The immunologic role of these antigens is unclear. We recently describ... | {
"pile_set_name": "NIH ExPorter"
} |
Band 3, the major intrinsic glycoprotein constituent of the erythrocyte membrane is responsible for anion transport. Selective in situ proteolysis of this protein has been used to define domains of the protein, certain of which are glycosylated. It is the objective of this research to determine the sequence, linkage an... | {
"pile_set_name": "NIH ExPorter"
} |
This program continues to study the behavioral effects of brain lesions in children and adults. The aim of our experiments is directed toward five topics: 1. Language and related nonverbal capacities considered as significant indices of left-hemisphere function. 2. Certain perceptual achievements, particularly the reco... | {
"pile_set_name": "NIH ExPorter"
} |
Breast cancer among Filipina American women represents a major but largely neglected cancer disparity; -first, though not as highly visible as other Asian subgroups, the Filipino population in the US is large, second among Asians only to the Chinese. Second, Filipinas have higher rates of breast cancer incidence than m... | {
"pile_set_name": "NIH ExPorter"
} |
Prostanoids exert profound physiological effects on the urinary tract including nociception, induction of smooth muscle contractility, enhancement of cell proliferation, and blood flow regulation. The rate-limiting step in prostanoid synthesis is catalyzed by cyclooxygenase (COX). This enzyme exists in two isoforms: CO... | {
"pile_set_name": "NIH ExPorter"
} |
The isolation of alpha-aminolevulinate synthetase (ALA-S) from livers of induced chick embryos is being continued; with purified enzyme, an antibody will be developed to study the induction mechanism and the transport of the enzyme from the microsome into the mitochondria where it is active. Chlorinated hydrocarbons bo... | {
"pile_set_name": "NIH ExPorter"
} |
To meet the dual threats of emerging infectious diseases and engineered biowarfare/bioterror agents, there is a pressing need for more efficient systems for vaccine development. TRIAD, or the Translational Immunology Research and Accelerated [Vaccine] Development program, based in the Biotechnology Program at the Unive... | {
"pile_set_name": "NIH ExPorter"
} |
The purpose was to determine if whole body and skeletal muscle glutamine and leucine metabolism are altered in HIV-infected subjects. Six HIV-infected men with chronic stable opportunistic infections and 10% weight loss, 8 HIV-infected men and 1 woman without wasting and 6 HIV- negative age-and weight-matched men were ... | {
"pile_set_name": "NIH ExPorter"
} |
The goal of the proposed research is to understand the mechanisms of how genes are regulated in different tissues. This will be accomplished through the study of the human gene encoding debranching enzyme and molecular analysis of Type III glycogen storage disease. In this disease there are patients who lack debranchin... | {
"pile_set_name": "NIH ExPorter"
} |
The effect of experimental conditions related to the induction of atherosclerosis will be studied with an emphasis on changes in elastin fiber formation. The conditions which will be studied include hypertension, hyperlipidemia, and hyperinsulinemia. Hypertension will be induced by galactose intoxication, which in avia... | {
"pile_set_name": "NIH ExPorter"
} |
We plan to isolate and analyze zebra fish mutants with altered visual systems. Of particular interest initially will be mutants with altered organizations of retinal cell types, and specific enrichment procedures will be utilized to aid in the isolation of such mutants. The mutants will be analyzed by behavioral, anato... | {
"pile_set_name": "NIH ExPorter"
} |
The importance in the understanding of the basic mechanism of human plasminogen activation is underscored by the wide use of fibrinolysis in the therapy of some blood clotting and cardiovescular disorders. Staphylokinase is a plasminogen activator protein secreted by strains of Staphylococcus aureas. Limited data from ... | {
"pile_set_name": "NIH ExPorter"
} |
Heart disease is the leading cause of morbidity and mortality in the Western World. As this is mostly related to disorders of the blood supply to the heart, it is very important to be able to assess the perfusion of the heart wall. Conventional methods for assessing myocardial perfusion have many limitations, including... | {
"pile_set_name": "NIH ExPorter"
} |
The work being carried on is quite varied in method and approach, but has one consistent aspect: the application of conditioning and training theories and methods to the empirical analysis of concepts important to theories of social behavior, motivation, psychopathology, and personality development. The major focus has... | {
"pile_set_name": "NIH ExPorter"
} |
It is known that individuals with peripheral arterial disease are at increased risk for cardiovascular morbidity and mortality. In order to facilitate design of a trial to evaluate the effects of intervention on risk factors on morbidity and mortality in such patients a feasibility study (ADMIT) has been designed to ev... | {
"pile_set_name": "NIH ExPorter"
} |
Importance: Intimate partner violence (IPV) is a serious national problem noted in Healthy People 2010 and the CDC Injury Research Agenda. The Deaf community is an understudied linguistic, cultural, and disability minority group whose IPV risks and experiences are virtually unknown. Preliminary studies, most conducted ... | {
"pile_set_name": "NIH ExPorter"
} |
With the increased use of prenatal screening by ultrasound, more fetuses are being diagnosed as potentially having congenital renal obstruction (2-5% of all pregnancies in the US). To date, the most common cause of renal failure in children is from renal damaged caused by urinary obstruction. Many controversies exist r... | {
"pile_set_name": "NIH ExPorter"
} |
The Pathology Core goal will continue to serve as a resource for the investigators interested in neurogenetics research. The resources include a tissue bank and providing neuropathological expertise in the analysis of murine and human normal and lesional tissue associated with Neurofibromatosis 2 (NF2), Schwannomatosis... | {
"pile_set_name": "NIH ExPorter"
} |
The pol gene of the human immunodeficiency virus (HIV) encodes three viral enzymes, reverse transcriptase, protease and integrase, which are critical for the replication of HIV. This project focused on the discovery of inhibitors of one of these viral enzymes, HIV reverse transcriptase (HIV RT). The broad objectives ar... | {
"pile_set_name": "NIH ExPorter"
} |
Background and Objective: [unreadable] Previously, all experiments examining protein protein interactions in living cells by FRET have been limited to the use of two fluorescent proteins.[unreadable] Here, we report the development of a novel FRET technology for studying complexes involving three proteins.[unreadable] ... | {
"pile_set_name": "NIH ExPorter"
} |
The free Ca2 ion concentration (Ca2 ion) of the cytosol, an important parameter in the regulation of carbohydrate metabolism, is itself regulated through the combined actions of the Ca2 ion transport systems of cellular membranes. Since these systems have been studied under unphysiological conditions, little is known o... | {
"pile_set_name": "NIH ExPorter"
} |
The study of tolerance to self-antigen in B-cells is of the utmost importance to understand how the immune system is regulated in health and disease. Unfortunately, the study of human B-cell tolerance has been hampered by the inability of investigators to identify an abundant population of autoreactive B-cells with hom... | {
"pile_set_name": "NIH ExPorter"
} |
While most women are overweight or obese when they reach menopause, we know little about how obesity affects this transition and its impact on metabolic health. We have hypothesized that the enhanced production of estrogens in peripheral tissues of obese women protects adipose tissue, skeletal muscle, and bone from the... | {
"pile_set_name": "NIH ExPorter"
} |
West Nile Virus (WNV) is one of the many neurotropic flaviviruses that is widely spread throughout the world, and continues to cause significant morbidity and mortality. In the US alone there were 24,000 cases of human WNV infection and 1000 fatalities since 2006. Both innate and adaptive immune components, including C... | {
"pile_set_name": "NIH ExPorter"
} |
[unreadable] This is a 5-year training program renewal to support 5 postdoctoral trainees (Ph.D. and/or M.D.), 4 predoctoral students (Ph.D. or M.D./Ph.D) and 3 short-term minority (BS or in MS program) students per year for years 21-25 with an emphasis on a multidisciplinary approach to understanding hematopoietic cel... | {
"pile_set_name": "NIH ExPorter"
} |
Coronary heart disease is the leading cause of death in the United States. The elderly, those older than 65 years of age, are more likely to have coronary disease and this problem will become even more pervasive as the population ages. Stenting of coronary blockages has become a conventional technique in both the emerg... | {
"pile_set_name": "NIH ExPorter"
} |
The early development of nerve-muscle synapses is characterized by three major events: (a) the accumulation of junctional acetylcholine receptors (AChRs), (b) the localization of synaptic acetylcholinesterase (AChE), and (c) the elimination of extrajunctional AChRs. This last event is mechanistically distinct from the ... | {
"pile_set_name": "NIH ExPorter"
} |
The objectives of this protocol are to compare the combination of 10-Ethyl-10- Deaza-Aminopterin (10-EdAM), mitomycin and vinblastin (EMV) with the combination of mitomycin and vinblastine (MV) in the treatment of patients with advanced Non-Small Cell Lung Cancer and to demonstrate that the two regimens are acceptable ... | {
"pile_set_name": "NIH ExPorter"
} |
The E4 allele of the Apolipoprotein E (ApoE) gene is the strongest genetic risk factor for the onset of sporadic Alzheimer's disease (AD) identified to date. The roles by which ApoE influences amyloid-beta (A2) metabolism and non-A2-mediated mechanisms in AD pathogenesis, however, remain to be fully clarified. The lite... | {
"pile_set_name": "NIH ExPorter"
} |
ABSTRACT Quantifying aging is a major goal in Geroscience research as the availability of a reliable marker of aging can facilitate understanding of the fundamental biology of aging, enable tracking of the aging process in different tissues and cell systems, and support identification and validation of interventions th... | {
"pile_set_name": "NIH ExPorter"
} |
as fresh samples for isolation of normal organoids or breast stem cells. The pathology core will provide normal breast tissue for stem cell studies (Polyak) and for 3-D organoid cultures (Brugge). Freshtumor samples will be provided to establish primary tumor xenograftsin mice Weinberg). In addition, Dr. Richardson wil... | {
"pile_set_name": "NIH ExPorter"
} |
The objectives of this study are 1) to test a group treatment program for women patients with borderline personality disorder (BPD) designed to decrease borderline symptoms and improve social functioning, and 2) to add to the understanding of the psychopathology of BPD by exploring a "level of emotional awareness" mode... | {
"pile_set_name": "NIH ExPorter"
} |
The specific aims of this Administrative Core include: 1) to provide the administrative structure to permit the effective day to day operation of the MCRC, 2) to provide the scientific expertise and leadership to identify and focus projects on clinically relevant issues and to insure that important unmet needs of under... | {
"pile_set_name": "NIH ExPorter"
} |
We propose to study the development of drug resistance in the context of HIV protease inhibition to develop and test structural and synthetic strategies in response to this mechanism. The overall goal of this Program Project is to understand the mechanisms of viral resistance, enabling modeling and design of more susta... | {
"pile_set_name": "NIH ExPorter"
} |
Fear of intracranial hemorrhage (ICH) is the primary reason that the only proven therapy for acute ischemic stroke is not provided to otherwise eligible patients. ICH also deters the development of more effective stroke therapies. New reperfusion strategies, using an intra-arterial (IA)approach, which may restore blood... | {
"pile_set_name": "NIH ExPorter"
} |
A group of seven qualifying Primary Users have detailed a broad range of experimental plans that specifically employ BIAcore analysis as summarized herein: (i) Characterization of association and dissociation rate constants for the interaction of immunoglobulin E (IgE) and the high affinity IgE receptor (FcepsilonRI) i... | {
"pile_set_name": "NIH ExPorter"
} |
The Center engages in collaborative research that leverages the Center's molecular modeling software, expertise and facilities to bridge experiment and computation. While experimental techniques unveil critical aspects of molecular and cellular architecture, computational molecular modeling describes biomolecular syste... | {
"pile_set_name": "NIH ExPorter"
} |
PROJECT 1 (MONTINE): Abstract Genetic risk for PD-related cognitive impairment and its disease mechanisms The inaugural PANUC award was funded to pursue the association of three candidate genes with cognitive impairment and dementia in PD: APOE ?4 allele and variants in SNCA and MAPT; to these we added GBA and LRRK2 mu... | {
"pile_set_name": "NIH ExPorter"
} |
This is a response to Notice Number NOT-OD-09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. The goal of this revision supplement is to extend our studies of nicotine vaccine efficacy in rats by introducing methods for the delivery of nicotine through inhalation of ciga... | {
"pile_set_name": "NIH ExPorter"
} |
This project is designed to investigate long-term regulation in brain of the enzyme choline acetyltransferase (CAT), catalyzing the biosynthesis of the neurotransmitter, acetylcholine. We shall study the biochemical basis for the observed multiplicity of molecular species of CAT and the mechanisms governing the regulat... | {
"pile_set_name": "NIH ExPorter"
} |
The 5-nitro drug, metronidazole (Mz), has been a mainstay of antimicrobial therapy for decades. Several of its simple derivatives such as tinidazole combine similar activity profiles with improved pharmacokinetic properties, but resistance to existing nitro drugs is increasing. Although commercial development of this d... | {
"pile_set_name": "NIH ExPorter"
} |
Antisense phosphodiester oligonucleotides, conjugated with acridine, and antisense methylphosphonate oligonucleotides, killed cultured Trypanosome brucei in the Phase I program. In the Phase II program, antisense olignucleotides will be edified at the base, sugar, and phosphodiester functional groups to increase their ... | {
"pile_set_name": "NIH ExPorter"
} |
The WHO Collaborating Center for Design, Methodology and Analysis of Epidemiological and Clinical Investigations in Diabetes was designated in 1986. The purposes of the Center are to collaborate with the World Health Organization in the implementation of the WHO/IDF action program to provide advice, consultation and co... | {
"pile_set_name": "NIH ExPorter"
} |
As implemented, outside of a handful of reference institutions, electronic health record (EHR) systems have not been conclusively shown to improve health outcomes. The New York City Primary Care Information Project (PCIP) is the nation's largest community EHR extension project, with 148 primary care practices and over ... | {
"pile_set_name": "NIH ExPorter"
} |
(Revised Abstract) Description: The rapid spread of HIV in many Eastern European countries has been linked to an increase in injecting drug use among young people. Non-injecting drug use has also increased among young people in this region. Non-injecting drug users are both at risk of initiating injecting drug use and ... | {
"pile_set_name": "NIH ExPorter"
} |
Examine differences between pre-term and full-term human milk. This study is also designed to identify material factorswhich may influence the concentrations and determine changes in concentrations which may result from storage of breast milk. | {
"pile_set_name": "NIH ExPorter"
} |
The Children's Cancer Study Group is a multi-disciplinary organization formed to cooperate in research into malignant diseases in children: specifically, to study the factors which may cause or influence these diseases, and to develop, evaluate and improve methods of treatment. The primary objective of the cooperative ... | {
"pile_set_name": "NIH ExPorter"
} |
Studies on long-term effects of two peroxisome proliferators inducing high and low carcinogenic activities respectively, indicated that factors other than oxidative injury may be important in the carcinogeneity of such chemicals. Speculation on the existence of specific receptors for mediating the action of peroxisome ... | {
"pile_set_name": "NIH ExPorter"
} |
PROJECT SUMMARY Breathing is a remarkable behavior fundamental to life that mediates gas exchange to support metabolism and regulate pH. A reliable, non-stop, robust rhythmic pattern of respiratory muscle activity is essential for breathing in mammals. Failure to maintain a normal breathing pattern in humans suffering ... | {
"pile_set_name": "NIH ExPorter"
} |
We are entering an exciting era in pediatric rheumatology. New treatment approaches are improving the lives of children with juvenile idiopathic arthritis (JIA) to such a degree that it's now rare to see wheelchairs or crutches in our waiting rooms. Even splints, commonly used in the past to treat joint contractures, a... | {
"pile_set_name": "NIH ExPorter"
} |
DESCRIPTION: (Adapted from the Applicant's Abstract.) This project is designed to describe some salient characteristics of mammalian cochlear hair cells. There are two types of such cells in our ears, inner hair cells and outer hair cells. The former are thought to be the true sensory receptors of the ear; they convey ... | {
"pile_set_name": "NIH ExPorter"
} |
[unreadable] The long-term goal of the proposed research is to develop an implantable polymeric device, which delivers gonadotropin releasing hormone(GnRH, aka leuteinizing hormone release hormone, or LHRH) in periodic pulses, mimicking the normal, ultradian endogenous rhythm. Rhythmic pulsed administration of GnRH has... | {
"pile_set_name": "NIH ExPorter"
} |
Mouse leukemia cells bearing TL surface antigens escape from destruction in mice immunized against those antigens, but the same cells are effectively killed when other antigens (e.g., H-2) serve as targets. Correlating with escape is the tendency for TL plus tumor cells to acquire resistance to TL antibody-\and guinea ... | {
"pile_set_name": "NIH ExPorter"
} |
End of preview. Expand in Data Studio
README.md exists but content is empty.
- Downloads last month
- 4