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To evaluate strategies that test the safety and effectiveness of therapeutic approaches/regimens to reduce the probability of the emergence of antibiotic drug resistance by minimizing unnecessary drug exposure. Trial title: A Multi-Center, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of a...	{ "pile_set_name": "NIH ExPorter" }
Our goal is to scintigraphically detect, stage and ultimately treat ovarian carcinomas, using radiolabeled monoclonal antibodies preferentially reactive with epithelial ovarian carcinomas. Monoclonal antibodies raised against ovarian cancer, already shown capable of radiolocalizing human ovarian carcinoma xenografts in...	{ "pile_set_name": "NIH ExPorter" }
ABSTRACT Autism spectrum disorder (ASD) is a devastating neurodevelopmental disorder of undetermined etiology and without effective therapeutics. Recent advances in genomic approaches have led to the identification of over 65 ASD risk genes. Despite the genetic heterogeneity of ASD, several lines of evidence suggest th...	{ "pile_set_name": "NIH ExPorter" }
Chronobiology is the study of biological rhythms. There are a number of chronobiological effects which may have important clinical implications for antitumor therapies. For example, chronobiological effects on the replication of some types of tumor cells, the expression of certain drug toxicities, and the number of cyt...	{ "pile_set_name": "NIH ExPorter" }
The long-term goal of the laboratory is to gain a structural understanding of the molecular organization and function of biological macromolecules at the biological membrane interface. Our focus of this study is to understand physical mechanisms of ion selectivity, conductance regulation, channel gating of ion channel ...	{ "pile_set_name": "NIH ExPorter" }
Neutrophil priming following trauma and sepsis is a key event implicated in causing Adult Respiratory Distress Syndrome (ARDS) and Multi-Organ Failure Syndrome (MOSF). Priming of the respiratory burst by cytokines following injury and sepsis results in excessive superoxide production by NADPH oxidase leading to auto-in...	{ "pile_set_name": "NIH ExPorter" }
During this period, the collaborative team is working to validate and characterize previously identified hits from primary SENP screening. As a center, the NCGC has fostered and maintained over 130 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire sp...	{ "pile_set_name": "NIH ExPorter" }
OBJECTIVES: 1. To disseminate and coordinate sickle hemoglobin education in the community; 2. To counsel patients with sickle cell disease and their families and establish ongoing relationships with hospitals, clinics and other health agencies; 3. To develop educational materials on sickle hemoglobin to be used locally...	{ "pile_set_name": "NIH ExPorter" }
Alveolar epithelial cells (AEC) cover the alveolar surface of the lung, which is the major acid-excreting organ in mammals. Because these cells are subject to an inconstant extracellular milieu with respect to pCO2, the regulation of intracellular pH (pHi) in alveolar epithelial cells is of particular significance. In ...	{ "pile_set_name": "NIH ExPorter" }
Abstract - Project 4: Cure rates for pediatric patients with relapsed or metastatic solid tumors remain unacceptably low. Cancer immunotherapies hold great promise, but scores of disappointing studies highlight our relative ignorance in understanding the immunosuppressive microenvironment within solid tumors. Because o...	{ "pile_set_name": "NIH ExPorter" }
The pulmonary involvement in disorders of immune or inflammatory regulation can range from a primary manifestation such as with sarcoidosis or a relatively minor manifestations such as seen with the Mendelian Susceptibility to Mycobacterial Disease immune deficiencies. While both of these can be associated with granulo...	{ "pile_set_name": "NIH ExPorter" }
RESEARCH EDUCATION CORE SUMMARY The goal of the Research Education Core is to attract and catalyze a new generation of diverse research professionals and biomedical scientists who are committed to elucidating and addressing the cancer disparities outcomes faced by so many in South Carolina and the US. During the five-y...	{ "pile_set_name": "NIH ExPorter" }
Understanding how memory develops in the immune system is an important issue in basic science and in clinical medicine, both in terms of promoting an immune response and, conversely, in blocking the pathway that leads to an overactive state (allergy, autoimmunity). However, the mechanisms underlying the generation of m...	{ "pile_set_name": "NIH ExPorter" }
We established that neurons present in dorsal root ganglia (DRG), similar to leukocytes, express a wide variety of receptors for cytokines, chemokines, opioids, anandamide and other neuropeptides. We previously showed that prior exposure to chemokines such as MIP1&#945;results in PKC mediated desensitization of the...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: It is hypothesized that estrogen deficiency induces a decrease in the rate of fat oxidation which leads to accelerated gain of visceral fat mass and its associated insulin resistance. It is further hypothesized that viscera fat accumulation will be prevented by hormone replacement therapy through restorati...	{ "pile_set_name": "NIH ExPorter" }
Our knowledge about the organisation of cells, biological specimen structures, composition and properties in submicroscopic detail of biological samples is associated to a large extent to transmission electron microscopy (TEM). The Electron Microscopy Core (EM Core) Facility provides advice, technical services, trainin...	{ "pile_set_name": "NIH ExPorter" }
Dr. Philippe Szapary plans a career as a clinician investigator at the University of Pennsylvania School of Medicine, focusing his research on the critical evaluation of complementary and alternative medicine (CAM). His training will include formal course work towards a Master's of Science in Clinical Epidemiology with...	{ "pile_set_name": "NIH ExPorter" }
Objectives: Sensorineural hearing loss (SNHL) is strongly associated with many aspects of military service including blast injury. The objectives of this proposal are to improve the prevention and treatment of SNHL in veterans. Research Design: To improve our understanding of cellular processes underlying hair cell (HC...	{ "pile_set_name": "NIH ExPorter" }
This research is directed toward synthesis and derivatization of novel DNA-binding peptides and detailed characterization of their DNA-binding and -condensing properties. A series of low molecular weight branched oligolysines and oligoarginines with a defined coupling site will be synthesized. We will determine the eff...	{ "pile_set_name": "NIH ExPorter" }
Chronic cigarette smoking is very common in alcohol use disorders (AUD). Nevertheless, the effects of chronic smoking on in-vivo measures of brain injury in alcohol-dependent individuals have not been studied. Thus, it is unknown if the full extent of brain atrophy, cell membrane and microstructural injury, derangement...	{ "pile_set_name": "NIH ExPorter" }
A method for attaching fluorescent receptor groups at specific sites in large RNA molecules will be developed. The sensitivity of the labels to the solvent environment and to energy transfer from nucleic acid bases, proteins, and metal ions will be used as a way of investigating RNA secondary and tertiary structure. A ...	{ "pile_set_name": "NIH ExPorter" }
The objectives of these projects are to: 1) develop equipment for use by investigators in Viral Oncology, 2) develop narrated, slide presentations for use by intra- and extra-mural members of oncogenic virus research on the hazards of laboratory procedures and equipment, 3) develop a training workshop for "Certificatio...	{ "pile_set_name": "NIH ExPorter" }
Puresyn, Inc. has developed purification processes for recombinant adeno-associated virus gene therapy vectors utilizing its proprietary chromatographic resin, PolyFlo. In Phase I, two tandem chromatography processes were developed: heparin affinity and PolyFlo and tandem PolyFlo in two different modes. Each process re...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
As a result of Phase I researches, a perfected design of a simple, reliable and economical phase modulation system has been achieved. Desig parameter perturbation and component selection has lead to this simplified and reliable design of a dual wavelength time sharing phase modulation spectrometer (dual wavelength PMS)...	{ "pile_set_name": "NIH ExPorter" }

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