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Jean White-Haney Rose Ethel Janet White-Haney (11 March 1877 – 21 October 1953), known as Jean White-Haney, was a botanist in Queensland, Australia. She was officer-in-charge of the Queensland Board of Advice on Prickly Pear Destruction and helped develop biological control methods for managing the invasive cactus. Jea... | https://en.wikipedia.org/wiki?curid=6192634 |
Jean White-Haney During this time she lived in Brisbane, becoming a founding member of the Lyceum Club and a committee member of the Queensland Bush Book Club. She attended the Pan-Pacific Science Congress in Tokyo in 1926 and was contracted by the Council for Scientific and Industrial Research, a position which took h... | https://en.wikipedia.org/wiki?curid=6192634 |
Rotating tank A rotating tank is a device used for fluid dynamics experiments. Typically cylinders filled with water on a rotating platform, the tanks can be used in various ways to simulate the atmosphere or ocean. For example, a rotating tank with an ice bucket in the center can represent the Earth, with a cold pole ... | https://en.wikipedia.org/wiki?curid=6193005 |
Yoshiki Kuramoto Yoshiki Kuramoto | https://en.wikipedia.org/wiki?curid=6195668 |
Vladimir Arnoldi Vladimir Mitrofanovich Arnoldi () (Kozlov (Michurinsk), Russia (1871–1924)) was a Russian professor of biology. He was a Corresponding Member of Russian Academy of Sciences and scientifically listed a number of valuable plants of Malaysia. He lived in the Russian city of Tambov for much of his life. Hi... | https://en.wikipedia.org/wiki?curid=6195887 |
Okorokov effect The () or resonant coherent excitation, occurs when heavy ions move in crystals under channeling conditions. V. Okorokov predicted this effect in 1965 and it was first observed by Sheldon Datz in 1978. | https://en.wikipedia.org/wiki?curid=6196217 |
John Morris (geologist) John Morris (19 February 1810 – 7 January 1886) was an English geologist. He was born in 1810 at Homerton, London, and educated at private schools. He was engaged for some years as a pharmaceutical chemist at Kensington, but soon became interested in geology and other branches of science, and ul... | https://en.wikipedia.org/wiki?curid=6196538 |
ISO 31-13 gives name, symbol and definition for 62 quantities and units of solid state physics. Where appropriate, conversion factors are also given. | https://en.wikipedia.org/wiki?curid=6197880 |
Association of the British Pharmaceutical Industry The (ABPI) is the trade association for over 120 companies in the UK producing prescription medicines for humans, founded in 1891. It is the British equivalent of America's PhRMA; however, the member companies research, develop, manufacture and supply 80% of the medici... | https://en.wikipedia.org/wiki?curid=6227790 |
Association of the British Pharmaceutical Industry The Research, Medical and Innovation department oversees complimentary resources for schools in UK to promote links between school science subjects and their applications in industrial research. The department also runs a careers website. The association sponsors bookl... | https://en.wikipedia.org/wiki?curid=6227790 |
Association of the British Pharmaceutical Industry It is regularly updated and reviewed in consultation with the Medicines and Healthcare products Regulatory Agency (MHRA), the British Medical Association (BMA), the Royal Pharmaceutical Society (RPS), the Royal College of Nursing (RCN), the Competition and Markets Auth... | https://en.wikipedia.org/wiki?curid=6227790 |
RTI International (formerly Research Triangle Institute) is a nonprofit organization headquartered in the Research Triangle Park in North Carolina. RTI provides research and technical services. It was founded in 1958 with $500,000 in funding from local businesses and the three North Carolina universities that form the ... | https://en.wikipedia.org/wiki?curid=6233389 |
RTI International In RTI's first year of operation, it had 25 staff and $240,000 in research contracts. Its early work was focused on statistics, but within a few years RTI expanded into radioisotopes, organic chemistry and polymers. In 1960 the Institute had its first international research contract for an agricultura... | https://en.wikipedia.org/wiki?curid=6233389 |
RTI International RTI has primarily eight practice areas: RTI also has a separate business called RTI Health Solutions, which supports biotech, diagnostic and medical device companies. As of 2012, the organization's largest service areas were in social, statistical and environmental sciences. More than half of RTI's st... | https://en.wikipedia.org/wiki?curid=6233389 |
RTI International In 1986, RTI was awarded a $4 million contract with the National Cancer Institute to conduct an eight-year clinical trial on the effects of an anti-smoking campaign. Two years later, RTI began a $4.4 million program to coordinate AIDS drug trials for the National Institutes of Health. This grew to $26... | https://en.wikipedia.org/wiki?curid=6233389 |
RTI International A 2009 study by RTI and the Centers for Disease Control and Prevention published in "Health Affairs" estimated that obesity in the US caused $147 billion in increased medical care costs annually. RTI also developed a reading skill measurement program, the Early Grade Reading Assessment (EGRA), for the... | https://en.wikipedia.org/wiki?curid=6233389 |
Viral culture is a laboratory technique in which samples of a virus are placed to different cell lines which the virus being tested for is able to infect. If the cells show changes, known as cytopathic effects, then the culture is positive. Traditional viral culture has been generally superseded by shell vial culture, ... | https://en.wikipedia.org/wiki?curid=6234485 |
Shiva Hypothesis William Napier (astronomer) and Victor Clube in their 1979 Nature Magazine article, 'A Theory of Terrestrial Catastrophism', proposed the idea that gravitational disturbances caused by the Solar System crossing the plane of the Milky Way galaxy are enough to disturb comets in the Oort cloud surrounding... | https://en.wikipedia.org/wiki?curid=6242575 |
Stanley Thatcher Blake (1910 – 24 February 1973) was an Australian botanist who served as president of the Royal Society of Queensland and who was associated with the Queensland Herbarium beginning in 1945 until his death. Prior to his stint with the Herbarium, Blake received a Walter and Eliza Hall Fellowship which al... | https://en.wikipedia.org/wiki?curid=6242974 |
Spectral energy distribution A spectral energy distribution (SED) is a plot of energy versus frequency or wavelength of light (not to be confused with a 'spectrum' of flux density vs frequency or wavelength). It is used in many branches of astronomy to characterize astronomical sources. For example, in radio astronomy ... | https://en.wikipedia.org/wiki?curid=6244916 |
Spectral index In astronomy, the spectral index of a source is a measure of the dependence of radiative flux density (that is, radiative flux per unit of frequency) on frequency. Given frequency formula_1 and radiative flux density formula_2, the spectral index formula_3 is given implicitly by Note that if flux does no... | https://en.wikipedia.org/wiki?curid=6245046 |
Spectral index It is worth noting that the observed emission can be affected by several absorption processes that affect the low-frequency emission the most; the reduction in the observed emission at low frequencies might result in a positive spectral index even if the intrinsic emission has a negative index. Therefore... | https://en.wikipedia.org/wiki?curid=6245046 |
2MASS 0532+8246 (full designation 2MASS J05325346+8246465) is possibly the first brown dwarf observed in the galactic halo of the Milky Way, and the first known substellar subdwarf star. It was discovered from Two Micron All-Sky Survey data, and verified by observations at Palomar Observatory and W. M. Keck Observatory... | https://en.wikipedia.org/wiki?curid=6247753 |
Ukrainian Shield In geology the (or Ukrainian Crystalline Massif) is the southwest shield of the East European craton. The and the Voronezh Massif consist of 3.2-3.8 Ga Archaean crust in the southwest and east, and 2.3-2.1 Ga Early Proterozoic orogenic belts. Ukrainian shield is approx. 1000 km long and up to 250 km wi... | https://en.wikipedia.org/wiki?curid=6253634 |
Honeycomb mirror A honeycomb mirror is a large mirror usually used as the primary mirror in astronomical reflecting telescopes whose face is supported by a ribbed structure that resembles a honeycomb. The design provides sufficient rigidity for ultra-high-precision optics while reducing the weight of the mirror. The re... | https://en.wikipedia.org/wiki?curid=6264576 |
Peter Demos Peter T. Demos (July 18, 1918 – September 18, 2012) was a professor in the Department of Physics and the Laboratory for Nuclear Science at MIT. A native of Peterborough, Ontario, Demos attended Peterborough Collegiate and Vocational School and Queen's University, and received a Ph.D. in Physics from MIT in ... | https://en.wikipedia.org/wiki?curid=6265178 |
Hatten Yoder Hatten Schuyler Yoder, Jr., (March 20, 1921 – August 2, 2003) was a geophysicist and experimental petrologist who conducted pioneering work on minerals under high pressure and temperature. He was noted for his study of silicates and igneous rocks. Yoder was born in Cleveland, Ohio on March 20, 1921. Yoder ... | https://en.wikipedia.org/wiki?curid=6270839 |
Ochrea An ochrea (Latin "ocrea", greave or protective legging), also spelled ocrea, is a plant structure formed of stipules fused into a sheath surrounding the stem, and is typically found in the Polygonaceae. In palms it denotes an extension of the leaf sheath beyond the petiole insertion. | https://en.wikipedia.org/wiki?curid=6272900 |
Karen Manvelyan () is an Armenian biologist and environmentalist who has worked in San Francisco as a scientist for much of his life. He is now director of the World Wildlife Fund in Armenia. | https://en.wikipedia.org/wiki?curid=6275930 |
Isotope fractionation describes processes that affect the relative abundance of isotopes, often used in isotope geochemistry. Normally, the focus is on stable isotopes of the same element. Isotopic fractionation in the natural environment can be measured by isotope analysis, using isotope-ratio mass spectrometry, to se... | https://en.wikipedia.org/wiki?curid=6284612 |
Metallogeny is the study of the genesis and regional-to-global distribution of mineral deposits, with emphasis on their relationship in space and time to regional petrologic and tectonic features of the Earth's crust. The term metallogeny (métallogénie) was created by , a professor at the Ecole des Mines de Paris, in h... | https://en.wikipedia.org/wiki?curid=6285648 |
Sequence (geology) In geology, a sequence is a stratigraphic unit which is bounded by an unconformity at the top and at the bottom. In a more rigorous and general way a sequence is defined as a "relatively conformable [...], genetically related succession of strata bounded by unconformities or their correlative surface... | https://en.wikipedia.org/wiki?curid=6286608 |
Compression (geology) In geology, the term compression refers to a set of stress directed toward the center of a rock mass. Compressive strength refers to the maximum compressive stress that can be applied to a material before failure occurs. When the maximum compressive stress is in a horizontal orientation, thrust fa... | https://en.wikipedia.org/wiki?curid=6286819 |
Olistostrome An olistostrome is a sedimentary deposit composed of a chaotic mass of heterogeneous material, such as blocks and mud, known as olistoliths, that accumulates as a semifluid body by submarine gravity sliding or slumping of the unconsolidated sediments. It is a mappable stratigraphic unit which lacks true be... | https://en.wikipedia.org/wiki?curid=6292451 |
GME of Deutscher Wetterdienst GME was an operational global numerical weather prediction model run by Deutscher Wetterdienst, the German national meteorological service. The model was run using an almost uniform icosahedral-hexagonal grid. The GME grid point approach avoided the disadvantages of spectral techniques as ... | https://en.wikipedia.org/wiki?curid=6298225 |
Succession (geology) In geology, a succession is series of strata or rock units in chronological order. Rock successions can be seen in cross-sections through rock, for example in a road cutting or cliff. With sedimentary layers of rocks, newer units will be above older units. | https://en.wikipedia.org/wiki?curid=6304351 |
Nanoporous materials consist of a regular organic or inorganic framework supporting a regular, porous structure. The size of the pores is generally 100 nanometers or smaller. Most nanoporous materials can be classified as bulk materials or membranes. Activated carbon and zeolites are two examples of bulk nanoporous mat... | https://en.wikipedia.org/wiki?curid=6308157 |
Lippmann electrometer A is a device for detecting small rushes of electric current and was invented by Gabriel Lippmann in 1873. The device consists of a tube which is thick on one end and very thin on the other. The thin end is designed to act as a capillary tube. The tube is half-filled with mercury with a small amou... | https://en.wikipedia.org/wiki?curid=6316384 |
IQVIA IQVIA, formerly Quintiles and IMS Health, Inc., is an American multinational company serving the combined industries of health information technology and clinical research. It is a provider of biopharmaceutical development and commercial outsourcing services, focused primarily on Phase I-IV clinical trials and as... | https://en.wikipedia.org/wiki?curid=6324689 |
Turbophoresis is the tendency for particles to migrate in the direction of decreasing turbulence level. The principle tends to segregate particles entrained in high velocity gases axially toward the wall region. Caporaloni et al. (1975) first found that because the vertical gradient of turbulence near a depositing surf... | https://en.wikipedia.org/wiki?curid=6343295 |
Certolizumab pegol (CDP870, tradename Cimzia) is a biologic medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-α) and is manufactured by UCB. is a monoclonal antibod... | https://en.wikipedia.org/wiki?curid=6352441 |
Kramers–Heisenberg formula The Kramers–Heisenberg dispersion formula is an expression for the cross section for scattering of a photon by an atomic electron. It was derived before the advent of quantum mechanics by Hendrik Kramers and Werner Heisenberg in 1925, based on the correspondence principle applied to the class... | https://en.wikipedia.org/wiki?curid=6363696 |
Carl Friedrich Schmidt (1832) Carl Friedrich Schmidt (, Fyodor Bogdanovich Schmidt; also known as Friedrich Schmidt; in Kaisma, Livonia – in Saint Petersburg) was a Baltic German geologist and botanist in the Russian Empire. He is acknowledged as the founder of Estonian geology. In the mid-19th century, he researched E... | https://en.wikipedia.org/wiki?curid=6372381 |
No-broadcast theorem In physics, the no-broadcast theorem is a result of quantum information theory. In the case of pure quantum states, it is a corollary of the no-cloning theorem: since quantum states cannot be copied in general, they cannot be broadcast. Here, the word "broadcast" is used in the sense of conveying t... | https://en.wikipedia.org/wiki?curid=6387477 |
Johannes Theodor Reinhardt (3 December 1816, in Copenhagen – 23 October 1882, in Frederiksberg) was a Danish zoologist and herpetologist. The son of Johannes Christopher Hagemann Reinhardt. He participated as botanist in the first Galathea Expedition (1845—1847). In 1848 he became a curator at the "Kongelige Naturhisto... | https://en.wikipedia.org/wiki?curid=6389068 |
Paul Fourmarier Paul Frédéric Joseph Fourmarier (25 December 1877 – 20 January 1970) was a Belgian geologist and specialist in tectonics, after whom Fourmarierite is named. Fourmarier was born in La Hulpe, Province of Brabant, Belgium and studied at the University of Liège, graduating in 1899. He became a professor of ... | https://en.wikipedia.org/wiki?curid=6389608 |
Prebiotic score A Prebiotic Score, also known as Prebiotic Activity Score, is a term sometimes used to estimate the health effects of prebiotics in humans or animals. The idea is that prebiotics may have many different effects in the human gut, some of these may be quantified and combined to an overall score. For examp... | https://en.wikipedia.org/wiki?curid=6395328 |
Prebiotic score The Prebiotic Index equation takes into account bifidobacteria (Bif), bacteroides (Bac), lactobacilli (Lac), and clostridia (Clos): <br> "PI = (Bif/Total) - (Bac/Total) + (Lac/Total) - (Clos/Total)" The rate of assimilation is the measure of the substrate assimilation calculated by measuring the substra... | https://en.wikipedia.org/wiki?curid=6395328 |
Synbiotics refer to food ingredients or dietary supplements combining probiotics and prebiotics in a form of synergism, hence synbiotics. The synbiotic concept was first introduced as "mixtures of probiotics and prebiotics that beneficially affect the host by improving the survival and implantation of live microbial di... | https://en.wikipedia.org/wiki?curid=6396920 |
Synbiotics Using prebiotics and probiotics in combination may be described as synbiotic, but the United Nations Food & Agriculture Organization recommends that the term "synbiotic" be used only if the net health benefit is synergistic. Synbiotic formulations in combination with pasteurized breast milk are under prelimi... | https://en.wikipedia.org/wiki?curid=6396920 |
Geological Conservation Review The (GCR) is produced by the UK's Joint Nature Conservation Committee and is designed to identify those sites of national and international importance needed to show all the key scientific elements of the geological and geomorphological features of Britain. These sites display sediments, ... | https://en.wikipedia.org/wiki?curid=6397354 |
Geological Conservation Review To date 36 of the planned 45 volumes have been published, with volumes 15 to 36 being published by JNCC directly, and available for sale through the Natural History Book Service, Totnes. The GCR is broken down into 107 'blocks' whereby sites with a similarly themed interest are collected ... | https://en.wikipedia.org/wiki?curid=6397354 |
Cecil Edgar Tilley Prof FRS HFRSE PGS (14 May 1894 – 24 January 1973) was an Australian-British petrologist and geologist. He was born in Unley, Adelaide, the youngest child of John Thomas Edward Tilley, a civil engineer from London, and his wife South Australia-born wife, Catherine Jane Nicholas. Cecil was educated at... | https://en.wikipedia.org/wiki?curid=6397814 |
Cecil Edgar Tilley From 1948 to 1951 he was President of the Mineralogical Society of Great Britain. He was President of the Geological Society 1949/50. He was elected an Honorary Fellow of the Royal Society of Edinburgh in 1957. He died at home in Cambridge on 24 January 1973 aged 78, and his body was cremated. In 192... | https://en.wikipedia.org/wiki?curid=6397814 |
Seeding (fluid dynamics) Seeding a material is a concept used in fluid dynamics to describe the act of introducing specific particulates or other foreign substances into a stream of fluid being evaluated. An altered fluid will be described as having a seeded flow. These particulates are generally small enough to be car... | https://en.wikipedia.org/wiki?curid=6398170 |
Vagabond (boat) Vagabond is a yacht specifically designed to sail in icy waters. In 2001, she was the first boat to go through the North-East passage without wintering. In 2002, she came back to France via the North-west Passage, completing the first circumnavigation around the Arctic ocean. "Vagabond" now serves as a ... | https://en.wikipedia.org/wiki?curid=6411296 |
DNA clamp A DNA clamp, also known as a sliding clamp or β-clamp, is a protein fold that serves as a processivity-promoting factor in DNA replication. As a critical component of the DNA polymerase III holoenzyme, the clamp protein binds DNA polymerase and prevents this enzyme from dissociating from the template DNA stra... | https://en.wikipedia.org/wiki?curid=6425322 |
DNA clamp In bacteria, the sliding clamp is a homodimer composed of two identical beta subunits of DNA polymerase III and hence is referred to as the beta clamp. In archaea and eukaryotes, it is a trimer composed of three molecules of PCNA. The T4 bacteriophage also uses a sliding clamp, called gp45 that is a trimer si... | https://en.wikipedia.org/wiki?curid=6425322 |
DNA clamp Certain NSAIDs (carprofen, bromfenac, and vedaprofen) exhibit some suppression of bacterial DNA replication by inhibiting bacterial DNA clamp. The sliding clamp in eukaryotes is assembled from a specific subunit of DNA polymerase delta called the proliferating cell nuclear antigen (PCNA). The N-terminal and C... | https://en.wikipedia.org/wiki?curid=6425322 |
DNA clamp The binding sites for these initiator proteins overlap with the binding sites for the DNA polymerase, so the clamp cannot simultaneously associate with a clamp loader and with a polymerase. Thus the clamp will not be actively disassembled while the polymerase remains bound. DNA clamps also associate with othe... | https://en.wikipedia.org/wiki?curid=6425322 |
Włodzimierz Trzebiatowski (February 25, 1906 in Grodzisk Wielkopolski – November 13, 1982) was a Polish chemist, physicist and mathematician. An institute in Wrocław, Poland called the Institute of Low Temperature and Structure Research is named after him. | https://en.wikipedia.org/wiki?curid=6431686 |
Bítov Castle (, ) is a castle on a steep promotory towering above the meandering River Želetavka, near the Vranov reservoir, in the village of Bítov, some northwest of Znojmo, Czech Republic. Built in the 11th century, Bítov is one of the oldest and largest Moravian castles. A Přemyslid fortified settlement originally ... | https://en.wikipedia.org/wiki?curid=6439042 |
Bítov Castle The structural arrangement of the castle through remodelling, which was carried out several times later on, is an example of the Czech Early Gothic castle architecture. The arrangement is highly intricate and leads in one direction towards the front moat, to which both the wedge-shaped round towers pointed... | https://en.wikipedia.org/wiki?curid=6439042 |
Zaven Khatchaturian Dr. Zaven Khachaturian is a neuroscientist and Alzheimer's disease researcher. Khachaturian previously worked for the National Institute on Aging. He is currently the head of research at the Alzheimer's Association in the United States. He was named the editor of the journal "Alzheimer's and Dementi... | https://en.wikipedia.org/wiki?curid=6446168 |
NGC 1023 Group The NGC 1023 group is a group of galaxies about 20.6 million light-years away from Earth. It is a group in the Local Supercluster along with the Local Group. The location of the NGC 1023 group within the Virgo supercluster (as part of the Laniakea supercluster) can be found near the center of this diagra... | https://en.wikipedia.org/wiki?curid=6446538 |
Overcast or overcast weather, as defined by the World Meteorological Organization, is the meteorological condition of clouds obscuring at least 95% of the sky. However, the total cloud cover must not be entirely due to obscuring phenomena near the surface, such as fog. Overcast, written as "OVC" in the METAR observatio... | https://en.wikipedia.org/wiki?curid=6446739 |
J. W. Kebabian Dr. John W. Kebabian is a neuropharmacologist and neuroscientist who was the first to discover that there were multiple subtypes of dopamine receptors. His pioneering work which was published in 1979 revolutionized the understanding of the role of dopamine receptors in cognition, movement and mental diso... | https://en.wikipedia.org/wiki?curid=6446769 |
NGC 2997 Group The NGC 2997 group is a group of galaxies about 24.8 million light-years from Earth containing NGC 2997 as a member. It is a group in the Local Supercluster along with the Local Group. G. De Vaucouleurs, 1975. Nearby Groups of Galaxies, ch. 5. the nearer groups within 10 megaparsecs. Published in "Galaxi... | https://en.wikipedia.org/wiki?curid=6447575 |
Canes II Group The or Canes Venatici II Group (CVn II Group) is a group of galaxies about 26.1 million light-years away from Earth. The group resides in the Local Supercluster. The largest galaxy within the cluster is M106 (NGC 4258), which is a barred spiral galaxy. Canes II is directly behind Canes I, which makes it ... | https://en.wikipedia.org/wiki?curid=6448233 |
Engineering science and mechanics (ESM) is a multidisciplinary and interdisciplinary engineering program and/or academic department. It is available at the Pennsylvania State University, University of Virginia, Virginia Polytechnic Institute and State University, Georgia Institute of Technology, or University of Alabam... | https://en.wikipedia.org/wiki?curid=6457764 |
Engineering science and mechanics In 1972, the department of engineering mechanics at the Virginia Polytechnic Institute and State University changed its name and undergraduate program to engineering science and mechanics. In 1974, the department of engineering mechanics at the Pennsylvania State University merged with... | https://en.wikipedia.org/wiki?curid=6457764 |
Brake force Brake force, also known as Brake Power, is a measure of braking power of a vehicle. In the case of railways, it is important that staff are aware of the brake force of a locomotive so sufficient brake power will be available on trains, particularly heavy freight trains. | https://en.wikipedia.org/wiki?curid=6462018 |
Cartes du Ciel ("CDC" and "SkyChart") is a free and open source planetarium program for Linux, macOS, and Windows. With the change to version 3, Linux has been added as a target platform, licensing has changed from freeware to GPLv2 and the project moved to a new website. CDC includes the ability to control computerize... | https://en.wikipedia.org/wiki?curid=6467957 |
Zinc finger nuclease Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this enables zinc-finger nucleases to target unique sequences within comp... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease Initial selection efforts utilized phage display to select proteins that bound a given DNA target from a large pool of partially randomized zinc-finger arrays. More recent efforts have utilized yeast one-hybrid systems, bacterial one-hybrid and two-hybrid systems, and mammalian cells. A promising n... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease Several different protein engineering techniques have been employed to improve both the activity and specificity of the nuclease domain used in ZFNs. Directed evolution has been employed to generate a FokI variant with enhanced cleavage activity that the authors dubbed "Sharkey". Structure-based de... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease In some instances, however, the repair is imperfect, resulting in deletion or insertion of base-pairs, producing frame-shift and preventing the production of the harmful protein. Multiple pairs of ZFNs can also be used to completely remove entire large segments of genomic sequence. To monitor the e... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease Their research work demonstrated that ZFNs can specifically and efficiently create heritable mutant alleles at loci of interest in the germ line, and ZFN-induced alleles can be propagated in subsequent generations. Similar research of using ZFNs to create specific mutations in zebrafish embryo has ... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease If the subject is homozygous for the target allele, the efficiency of the technique is reduced since the undamaged copy of the allele may be used as a template for repair instead of the supplied fragment. The success of gene therapy depends on the efficient insertion of therapeutic genes at the app... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease Initial targets likely include the causes of monogenic diseases, such as the IL2Rγ gene and the b-globin gene for gene correction and CCR5 gene for mutagenesis and disablement. If the zinc finger domains are not specific enough for their target site or they do not target a unique site within the ge... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease Since the protein must be expressed only transiently, however, the time over which a response may develop is short. Liu et al. respectively target ZFNickases to the endogenous b-casein(CSN2) locus stimulates lysostaphin and human lysozyme gene addition by homology-directed repair and derive secrete... | https://en.wikipedia.org/wiki?curid=6476735 |
Zinc finger nuclease ZFNickases demonstrate strand-specific nicking activity "in vitro" and thus provide for highly specific single-strand breaks in DNA. These SSBs undergo the same cellular mechanisms for DNA that ZFNs exploit, but they show a significantly reduced frequency of mutagenic NHEJ repairs at their target n... | https://en.wikipedia.org/wiki?curid=6476735 |
Helper virus A helper virus is a virus that allows an otherwise-deficient coinfecting virus to replicate. These can be naturally occurring as with Hepatitis D virus, which requires Hepatitis B virus to coinfect cells in order to replicate. Helper viruses are also commonly used to replicate and spread viral vectors for ... | https://en.wikipedia.org/wiki?curid=6478242 |
Limnetic zone The limnetic zone is the open and well-lit area of a freestanding body of fresh water, such as a lake or pond. Not included in this area is the littoral zone, which is the shallow, near-shore area of the water body. Together, these two zones comprise the photic zone. There are two main sources of oxygen ... | https://en.wikipedia.org/wiki?curid=6493525 |
Limnetic zone Many species of freshwater fish live in the limnetic zone because of the abundance of food, though these species often transition to the littoral zone as well. | https://en.wikipedia.org/wiki?curid=6493525 |
Pake doublet A Pake Doublet (or "Pake Pattern")is a characteristic line shape seen in solid-state nuclear magnetic resonance and electron paramagnetic resonance spectroscopy. It was first described by George Pake. It arises from dipolar coupling between two spin half nuclei, or from transitions in quadrupolar nuclei su... | https://en.wikipedia.org/wiki?curid=6507201 |
Pake doublet In the case the averaged lineshape is used to analyze crystal symmetry, phase transitions, and the degree of molecular disorder in crystalline hydrates, zeolites, clays and biological tissues. | https://en.wikipedia.org/wiki?curid=6507201 |
Coastal warning display tower A coastal warning display tower, also known as a storm warning tower, is a type of signal station in the form of skeletal towers designed to provide warnings of hazardous wind conditions in coastal areas. The towers were developed in 1898 on the orders of President William McKinley. Throug... | https://en.wikipedia.org/wiki?curid=6515277 |
Coastal warning display tower However, the system of using flags to indicate warnings related to strong winds in coastal areas remains in use by the U.S. Coast Guard, using ordinary flagpoles in lieu of the larger, more expensive, and more complex towers. At least one complete CWD tower, with all of its original equipm... | https://en.wikipedia.org/wiki?curid=6515277 |
Hyperchromicity is the increase of absorbance ("optical density") of a material. The most famous example is the hyperchromicity of DNA that occurs when the DNA duplex is denatured. The UV absorption is increased when the two single DNA strands are being separated, either by heat or by addition of denaturant or by incre... | https://en.wikipedia.org/wiki?curid=6518049 |
Hyperchromicity The two strands of DNA are bound together mainly by the stacking interactions, hydrogen bonds and hydrophobic effect between the complementary bases. The hydrogen bond limits the resonance of the aromatic ring so the absorbance of the sample is limited as well. When the DNA double helix is treated with ... | https://en.wikipedia.org/wiki?curid=6518049 |
Impalefection is a method of gene delivery using nanomaterials, such as carbon nanofibers, carbon nanotubes, nanowires. Needle-like nanostructures are synthesized perpendicular to the surface of a substrate. Plasmid DNA containing the gene and intended for intracellular delivery, is attached to the nanostructure surfac... | https://en.wikipedia.org/wiki?curid=6520671 |
James William McBain FRS (March 22, 1882 – March 12, 1953) was a Canadian chemist. He gained a Master of Arts at Toronto University and a Doctor of Science at Heidelberg University. He carried out pioneering work in the area of micelles at the University of Bristol. As early as 1913 he postulated the existence of "coll... | https://en.wikipedia.org/wiki?curid=6524119 |
NGC 5713 is a peculiar, asymmetric galaxy in the constellation Virgo. Although classified as a spiral galaxy by most galaxy catalogs, galaxy is very different from most normal spiral galaxies. While most spiral galaxies either have either two well-defined spiral arms or a filamentary spiral-like structure, this spiral ... | https://en.wikipedia.org/wiki?curid=6535757 |
Tuft (aeronautics) In aviation, tufts are strips of yarn or string, typically around , attached to an aircraft surface in a grid pattern and imaged during flight. The motion of the tufts during flight can be observed and recorded, to locate flow features such as boundary layer separation and reattachment. Tufting is, t... | https://en.wikipedia.org/wiki?curid=6539344 |
Cloudscape (art) In art, a cloudscape is the depiction of a view of clouds or the sky. Usually, as in the examples seen here, the clouds are depicted as viewed from the earth, often including just enough of a landscape to suggest scale, orientation, weather conditions, and distance (through the application of the techn... | https://en.wikipedia.org/wiki?curid=6539646 |
Cloudscape (art) " There are some later cloudscape paintings - for example, the famous cloudscapes of Georgia O'Keeffe - in which the clouds are seen from above, as though viewed from an airplane. According to an essay at the website of the Metropolitan Museum of Art, "Among the most dramatic and well-known images of O... | https://en.wikipedia.org/wiki?curid=6539646 |
National Marine Science Centre, Australia The National Marine Science Centre (NMSC) is part of the School of Environment, Science and Engineering, at Southern Cross University. Located in Coffs Harbour, New South Wales, on the east coast of Australia and adjacent to the Solitary Islands Marine Park, where both tropical... | https://en.wikipedia.org/wiki?curid=6549164 |
National Marine Science Centre, Australia The Centre is sited within the grounds of the Novotel Pacific Bay Resort, a few kilometers north of Coffs Harbour. The building was at one time the resort's sports centre, gymnasium, squash courts, and alfresco restaurant. | https://en.wikipedia.org/wiki?curid=6549164 |
Gonzalo Trancho Gonzalo Javier Trancho Gayo (Madrid, 8 February 1955) is a Spanish anthropologist. He obtained doctor and bachelor degrees in Biological Sciences at the Universidad Complutense de Madrid, where he is also a professor in the Zoology and Anthropology Department. His thesis dealt with a cell biology study ... | https://en.wikipedia.org/wiki?curid=6554334 |
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