Entry stringlengths 6 10 | EC_number stringclasses 260
values | Active_site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q6ZMQ8 | 2.7.11.1 | ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNV... | 99 |
A0CA73 | 2.7.1.21 | ACT_SITE 85; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | MFTGTISVIYGPMFSGKTSELMRLVKRFTISERKCAVLNYANDNRYSDDQCISSHDKQYLKAIKVTKLFDAFEKCKDYDVVAIDEGQFFCDIVEFSEAMANLGKIVIVAALDGTFDRKPFRNILSLIPLAERITKLTAVCWFCKKENASFTKRTVQSQEIELIGGEDCYKPACRACFNLTEDKFEKHTLSQIPVYSNDERLFGQQNLIC | 88 |
Q1LX51 | 2.7.10.2 | ACT_SITE 315; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKWSEMASVNATQQHLNFSSSWEEDSSDNSFDEWTHKSVPLRSPCRTPRIQRHRNRSITVSPSVPTSPIPYAAWKKLRLCDSPSTPKSLLSKSTMPCSSSKTCRSQRFLRLSTAFERVPSVNINPFTPDTVRRNSEHYKRKSQRSDDDEDYGPRSKEIQNSSEDESFFLPSKRPAVSARMLSRYESEFLELACIGVGEFGSVYRCVKRLDGCMYAIKRSRRPIAGSANEQLALKEVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCDGGSLHDAITEKREQGEFFSVPELRDLLLQVSMGLKYIHNSGLVHLDIKPSN... | 98 |
G7ICT5 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVKMHAILSIATLVIVILSVSTTLASSTSLKYGFYKTTCPSAEAIVRRAVNKAVSLNPGITAGLIRMHFHDCFVRGCDGSVLLDSIPGIRSERDHPANNPSLRGFEVINEAKAQIEAACPKTVSCADILAFAARDSARKVSGGRIDYSVPSGRRDGRVSIFDEVTQNLPPPTFSAEQLIDNFDRKGLSVDEMVTLSGAHSIGVSHCSSFSKRLYSFNATFPQDPSMDPDFARLLRSKCPPPQSQQSQSQIQNLDSTVAFDGSTPNDLDNMYYKRLKNNRGLLTSDQILVNSGLTKRMVLKNARHAAIWNVKFAKAMVHMG... | 14 |
A0A1U8JHV1 | 3.1.1.11 | ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MANIRQPLLDRPRGSYSRDCPLIFTLVLLICLAALVAIPLVRFSSFDANHPYKYCERAVDQKSCSALLSEVASKTTVRTKGVDLLHAFLERSASDIQNVINQARNFNDGINNRREQASSADCLELMELSRDRIMDSMVGVEKQDVNWHSNAQAWLSSVLTNHVTCLDGLQGSVRTLMEPGLSDLISKARTSLAILVSVSPTKTEFDDDPLTGGFPSWLSSKDRKLLQALPNEIKADVVVAKDGSGNYKTLGEAVATAPDKSKTRYIIHVKKGTYKENVEIGANKKNLMIVGDGMNSTIITGSLNVIDGSTTFKSATVAAV... | 125 |
H2MIE3 | 2.7.10.1 | ACT_SITE 820; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MERHQPARGANRELAGFQAAHMAAKLWRTLSASIWILTLASSSRTRIYPPNEVTLLDTRTVPGELKWAARPSEGGWEEVSIMDEKNIPIRTYQVCNVLGPNQNNWLRTDWIPRSGAQRVYVEVKFTLRDCNSLPGVTGTCKETFNLYYHESNEDRESYIKESSFIKVDTVAADESFTQVDVGDRIMKLNTEVRDVKVTNRKGFYLAFQDVGACIALVSVRVFYKTCPLTIRNLATFPDTVTGADTSSLVEVRGSCVNQSEEREEPKMYCGADGEWLVPIGGCLCNPGYEEKGGSCQACSAGFYKAKSSDIGCSKCPPHSH... | 97 |
A0A2G2YHJ2 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPGLTIGDDLPNLEVETTNGKMKLHDYVGDSYTILFSHPGDFTPVCTTELGMMAAYANKFAERGVKLLGLSCDDVHSHKEWIKDIEAYNKGHKVTYPIIADSKRELIKQLNMVDPEETDSSGHKLPSRALHIVGPDKKKAAKHKIATPANWKPGEPVVISPNVSTEQAKEMFPQGFDTANLPSGKSYLRFTNV | 12 |
I1JFF0 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKINILLCVVLLGFLGVCQGGSLRKKFYKDSCSQAEDIIKSKTQQHVSANPDLPAKLLRMHFHDCFVRGCDASVLLNSTANNTAERDAIPNLSLAGFDVIDDIKSELEAKCPKTVSCADILALAARDAVSVQFNKSMWEVLTGRRDGTVSNSNEALANIPAPFFNFTQLKQNFASKGLTLHDLVVLSGAHTIGIGHCNLFSNRLYNFTGKGDQDPSLNSTYAEFLKTKCQSLSDTTTTVEMDPGSSTNFDSDYYPNLLQNKGLFQSDAALLTEEQSEDIAKELVDQDKFFTEFAQSMKRMGAIDVLTDSAGEIRNKCSVV... | 14 |
A0A1Y1IRA0 | 1.11.1.6 | ACT_SITE 57; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 130; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MGSYRGPILTNGAGHPVSDDNNSVTIGETGSILLEDFHLLDKLAHFDRERIPERVVHAKGAGAHGYFEVTHDVSDICKAKFLDRVGKRTRCFTRFSTVGGESGSADTARDPRGFAVKFYTEEGIYDLVGNNTPVFFIRDPLKFPDFIHTQKRNPETHLKDPDMFWDFLSLVPESVHQVMILFSPRGTPDGYRFMNGYGSHTFKWVNDHGKAHWVKIHYKTDQGIKNLTTEQADHLAGSDPDYATRDLSNAIKRGEYPSWTFYVQAMPLEDAERFDWDPFDLTKVWPHKQYPLRQFGRMVLNRNPANYFAEVEQAAFSPAH... | 13 |
A0A452DII9 | 2.1.1.37 | ACT_SITE 1333; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MNECLRQGSQQMEELGQIHCSAQGCAPPSRMRDPCAEPVPLPPPTHGTASLCVVRPDFPHAWAGMVRAASARGPSPSVSARKARVACAAAASAAPSKMPARTAPARVPALASRAFSLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLRTEIKNQLCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSREANGCLENGSQTSGEDCRVVMAEKGKPPKPVSRLYTPRRSKSDGETKSEVSSSPRITRKTTRQTTITSHFPRGPAKRKPEEEPEKVKSDDSVDEEKDQEEKRRRVTSRERVAGLLPAEEPGR... | 47 |
P83102 | 2.7.12.1 | ACT_SITE 402; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVGSQEKKNNHIELSETPATDKNNLNTTHLENTQLSKALSPPTSLPQIQIQMINQNLTHTGIAQNNTEKANRHQYRDSGLQYLTRCFEPLAMLNDSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGLFLRTISENSKSKSEPECESLISVKESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEE... | 107 |
Q06098 | 2.7.11.1 | ACT_SITE 280; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNSTPPTSPVTRVSDGSFPSISNNSKGFAYRQPQKHKSNFAYSHLVSPVEEPTAKFSEAFQTDYSSKAPVATSEAHLKNDLDVLFTTPRFYSPENLALMFRLSNTVSSLEFLDEFLMGILLAPEMDFLSNPSYSLPSNKLVGQGSYSYVYPISSSASSRCNNDSGVVLKFAKSQHKSKVILQEALTLAYLQYMSPSTNESHIIPFYGLTYITKSHFRRLRSNECVPGLILPKCEMSLYHFNTAVSHKLSLITKRKIWWRLMKQMIDALKSLKTNGIIHGDIKTANILITEMHVLNGGHCKDFDFYLADFTSAFHINQTPT... | 99 |
Q54UF3 | 4.1.1.17 | ACT_SITE 402; /note="Proton donor; shared with dimeric partner"; /evidence="ECO:0000250|UniProtKB:P11926" | MTGTKRNGEEVVNENNNNNVAEETNKKAKVDESSTETTESTSCSLLSRCEKLDIVRKELDVKPWDQGKVTIQELITSLLDKTDRDAFFVADVGVIIKQWQKWVKNLPNVKPYYAVKCNPTVGVLRVLDALGTNYDCASRTEIESVLNLGVDPSRIIYANPCKQISALKFARAHNVKLMTFDNLSELEKIEKFFPEAELVLRIAPDDSKSVMRFGSKFGVHIDDCNDLLEMAKEMNLKVVGVSFHVGSGCQSGDSYADALIMVKSVFDMAKKLNMELTLVDVGGGFTGSDDEKFNAFTKVIREKTAELFSPNVKIIAEPGR... | 195 |
A0A1S4H1N3 | 4.1.1.50 | ACT_SITE 81; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 95; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 285; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAESEDLSNSSSNSSSREDMHFFEGVEKLLEIWFEPSTACKNADLRKIPRPMWDALLKTVRCEIISFTRNDQIDAYVLSESSMFVSKRRWILKTCGTTTPLQCFEPLLRLAAEIAGYTEIEDLFYSRKNYKRPELQVSPHRGFDEEVAFLDSFFDDGRAYSLGAINRDCWHLYTLSRGGGGSKILKRNNHLHQLMEQHHSQQLQQQQQEDDDVQQLDAQLIEASMQPDPDQTIEILMTDLDPSVMAIFTKDVCTTAKEATQKSGIHRLLPGMVIDDYLFDPCGYSMNGISKNGCYMTIHITPEREFSYVSFESNVASSDY... | 196 |
W5N3C2 | 2.7.10.1 | ACT_SITE 722; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MNEPRPSRPVLQPGFPGNSTVVAGSDVELHCRVSGTARARIQWFRPVERDGSVSVPGGPPYLRALTPNRLNVSKGSSLRLANVSLADAGEYVCVAESSAGRDQRSAWLTVLTDLILFECEQMKRTELKGHAWENTRISKDETTEQFFLEPGEVLKLTCDANRTGGIHWFKGDMRIHHGDRIQIQANTMEISEVTYEDSGPYLCVTRGTREVLRNFTITVVDSLESGDDDEDNGLEDTMADVDEEQTYYTRGPYWTHTQRMEKKLYAVPAGNTVKFRCPAMGSPLPTIRWLKNGREFRGEHRIGGIKLRHQHWSLVMESVV... | 97 |
B5YHC8 | 3.4.21.89 | ACT_SITE 37; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MTGKKILEYVKSIGIAILIALFIRAYIVQAFKIPSGSMIPTLLIGDHLLVNKFIYGVNPPLSDEKILVFETPKRGDIIVFKYPEDPSRDFIKRVIGVEGDTVEIKNKKVFVNGIELKEPYARHTDSYIHPRELDPRDNFGPIKVPPHKLFVMGDNRDQSYDSRFWGFVDLKDVKGKAFIIYWSWDNDNHKPRLQRIGKLIK | 178 |
A0A804JXS0 | 3.2.1.1 | ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 225; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MKPLLLAFVFLVVLSLTTAQSQILFQGFNWESWRKQGGWYNFLRSQVPDIARAGVTHVWLPPPSHSVSEQGYMPGRLYDLNASKYGTRDELKSLIAAFHDKGIKCVADIVINHRCAERKDARGIYCIFEGGTSDSRLDWGPHMICSDDTQYSDGTGNRDTGGDFGAAPDIDHLNQQVQQELTDWLNWLRTDIGFDGWRLDFARGYSPSIAKIYVSHTSPDFVVAELWSSLTYGGDGKPAYDQDGSRQELVNWVHDVGGPAAAFDFTTKGVLQAAVQGELWRLRDPQGKASGMIGWWPEKAVTFVDNHDTGSTQKLWPFPS... | 157 |
P64180 | 1.2.1.12 | ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q6GIL8" | MSTNIAINGMGRIGRMVLRIALQNKNLNVVAINASYPPETIAHLINYDTTHGKYNLKVEPIENGLQVGDHKIKLVADRNPENLPWKELDIDIAIDATGKFNHGDKAIAHIKAGAKKVLLTGPSKGGHVQMVVKGVNDNQLDIEAFDIFSNASCTTNCIGPVAKVLNNQFGIVNGLMTTVHAITNDQKNIDNPHKDLRRARSCNESIIPTSTGAAKALKEVLPELEGKLHGMALRVPTKNVSLVDLVVDLEKEVTAEEVNQAFENAGLEGIIEVEHQPLVSVDFNTNPNSAIIDAKSTMVMSGNKVKVIAWYDNEWGYSNR... | 22 |
A0A072TVL2 | 5.3.1.8 | ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEDSNPNNSLQKLHCSVKNYDWGLPGQLSQVAKLSELNSGFKFDPMKPYAELWIGTHDSGPSFLVSDDDGQRISLKDWIFDNPDLLLGHKVVKKWGSDLPFLFKVLSVGKALSIQAHPDKELARMLHKLHPDVYKDGNHKPEMALAMTDFEALCGFITLKELKAVIHTVPEVVNLVGASNANLVLETSDQNEEKVKPVLQAVFTHLMSASKEIVTDAVNRLINRLHEESEMRHLTEKELLVLRLENQYPSDIGVIAAFFLNHVKLNPGEALFLGANEPHAYLSGECIECMATSDNVVRAGLTPKFIDVPTLCSMLTYKQG... | 214 |
P36004 | 2.7.11.1 | ACT_SITE 563; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVMQEEKKRQQPVTRRVRSFSESFKNLFRPPRSRDSSPINVTRIPYRSSSTSPKRSSEPPRRSTVSAQILDPKNSPIRQRSYTLKCCTPGLSHPFRQTGSGASNSPTRHRSISGEEQEIVNSLPEYKRSASHTFHGIRRPRSRSSSVSSCDSSNGTTSSSDSQWAMDSLLDDSDNDLTPYRGSNKDILKSKDRAPYNYIDDYNKKALRRATSYPNPLPSKQFYNERLYTRRSHPDEESLESLPRFAGADVQCIIEQNGFKVYEDGSHEHNIKLSGVIAKLEKGNSLPAHRQGSLSRPRLGITLSGLFKHHKNECDIENAL... | 99 |
Q8NFD2 | 2.7.11.1 | ACT_SITE 145; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEV... | 99 |
Q9BGI1 | 1.11.1.24 | ACT_SITE 105; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P30044" | MRLGWLRVLGCRPGSVVSRATIVEGASTTAAGTRGCLEGILEWTFGGVRGFRSAAVAMAPIKVGDAIPSVEVFEKEPGNKVNLAELFKGKKGVLFGLPGAFTPGCSKTHLPGFVEQADALKAKGIQVVACLTVNDVFVTEEWARAHKAEGKVRLLADPSGTFGKETDLLLDDSLLFLFGNHRLKRFSMVIEDGIVKSLNVEPDGTGLTCSLAPNILSQL | 12 |
C5YZJ3 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSRSTWLAFAWAAALVVVVVAASTTTTAHASHHASLEVGFYKHSCPEAESIVRDAVRRGVARDAGVGAGLIRMQFHDCFVRGCDASILINSTPGNKAEKDSVANNPSMRGFDVVDDAKAVLEAHCPRTVSCADIVAFAARDGAYLAGGLDYKVPSGRRDGRVSREDEVLDSNVPAPFDDVAELIQSFKRKGLTADDMVTLSGAHTIGRSHCSSFTQRLYNFSGQLGRTDPSLDVAYADHLKMRCPWPSSDGKRHPAVVPQDPVTPATFDNQYFKNVVAHKGLFVSDKTLLDSTCTAGIVHFNAAVDKAWQVKFAKAMVKM... | 14 |
Q8REF0 | 3.5.1.88 | ACT_SITE 134; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MVYKIKKYGEDVLKQIAKEVELSEINDEFRQFLDDMVETMYETDGVGLAAPQIGVSKRIFVCDDGNGVLRKVINPIIVPLTEETQEFEEGCLSVPGIYKKVERPKRVLLKYLNEYGKEVEEIAENFLAVVVQHENDHLDGILFIEKISPMAKRLIAKKLANIKKETKRIKEENE | 183 |
Q942L2 | 5.3.4.1 | ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 67; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 183; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 186; /note="Nucleophile"; /evidence="ECO:0000250" | MAIPRISPRKTLPLFAALALALAWAFAAPAFADGDDVVALTESTFEKEVGQDRGALVEFYAPWCGHCKKLAPEYEKLGASFKKAKSVFIAKVDCDEHKSVCSKYGVSGYPTIQWFPKGSLEPKKYEGQRSAEALAEFVNTEGGTNVKLATIPSSVVVLGPDNFDSIVLDENKDILVEFYAPWCGHCKHLAPIYEKLASVYKLDDGVVIANLDADKHKDLAEKYGVSGYPTLKFFPKGNKAGEDYDGGRELDDFVKFINEKCGTSRDTKGQLTSEAGRIASLDALAKEFLGAANDKRKEILSNMEEEVVKLSGSAAKHGKV... | 215 |
M5VVU6 | 3.2.1.1 | ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MKSLTTLFCVLLCINLLPNFAASQILFQGFNWESWKTEGGWYNSLRKSVPELASSGITHVWLPPPSQAASSEGYLPGRLYDLSASKYGSQDELKSLISAFHDSGIQAVADIVINHRTAEKQDERGIWCIFEGGTPDNRLDWGPSLICSDDTQYSDGKGNPDTGAGYDAAPDIDHKNTRVQKELSDWMNWLKTEIGFSGWRFDFVRGYSPEITKLYMTNTSPNFAVGELWNSLAIGSDGKPEYNQDAHRQELAGWVEGAGGAVTAFDFTTKGILQAAVQGELSRLKDPNGRAPGMIGLLPGKSVTFIDNHDTGSTQKIWPF... | 157 |
Q89YX0 | 1.11.1.24 | ACT_SITE 44; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MKNIGDKAPEVLGINEKGEEIRLSAYKGKKIVLYFYPKDSTSGCTAQACSLRDNYSELRKAGYEVIGVSVDSEKSHQKFIDKNNLPFTLIADTDKKLVEEFGVWGEKKLYGRAYMGTFRTTFLINEEGIIERIITPKEVKTKEHASQILNQ | 12 |
Q6K461 | 3.6.1.52 | ACT_SITE 160; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MRQEATCSLVLTQDAQHRKNQPPLAEEDDDRDHTDDAMPPPCSILLRQEEGEATAAAAGEGLLVPPLNFAMVDHGVYRSGFPDISNLPFVESLRLRSVLCLCPEPYPEANQEFLRAHGIRLFQFGIDGSKEPFVNIPEDRIREALKVVLDVANHPVLIHCKRGKHRTGCVVGCLRKLQRWCLTSIFDEYQRFAAAKARVSDLRFMELFDISSLKHLPASFSC | 190 |
Q502C8 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MPIKVGQRLPAVEVQEEDPGNSLSMAELFSCKRGVLFGVPGAFTPGCSKTHLPGFIQMAGELRAKGVDEVACISVNDVFVMSAWGKQNGADGKVRMLADPTGAFTKAVDLVLNNAQLIPVLGNLRSQRYAMLIENGVVTKLSVEPDGTGLTCSLASNFLAEV | 12 |
A8XFY3 | 2.7.11.1 | ACT_SITE 228; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 586; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MGLQRGMPLAQLGEPFGITPAAIENVSPGIDQCKDHRIDASMRSEPSDYFSDTTNTFHSSIHVVHPTINNGTRMNKKESSASETEIDIGDVRKCGEKADRQQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKIRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMNQILKAKL... | 99 |
A0A0K9P698 | 2.7.1.11 | ACT_SITE 284; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MESRQVKNEIEAPVPRRVVGLYSCPDHSSSGNFVDIAACMPVRAPTPVGFGDVEPRAISKMSENVENDGDYFGKIVVGDDGFVLQDVPHLTDYISDLSTHTNPLQHNKSYSSVKQYFVDPDDTITQNIVVQKDGPRGIHFRRAGPRQQVYFKSDEVNACIVTCGGLCPGLNTVIREIVCGLSYMYNVNTIWGIECGYKGFYARNTIPLTSKYVNDIHKRGGTILGTSRGGHDTIKIVDSIQDRKINQVYIIGGDGTQKGASVIFEEIRRRDLKVSIFGIPKTIDNDIPVIDRSFGFDTAVEEAQRAINAAHVEAQSGENG... | 84 |
K3YIN6 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGAQMKSFVRLLILVQVAAILAGHGAAELSMDYYGMSCPYAEYIVRNVVGQALMKDPTLAGSILRLHFHDCFVQGCDASVLLDSTDDNTAEKDAPANKSLRGFEVIDSIKEALEEQCPGVVSCADVLALAARDAVFMARGPYYGVPLGRRDGSRSVASDTFLTLPPPIKNVTVLIQIFDKVGLDVHDMVALSGGHTLGIAHCANFKNRIKDETETLDATLASSLGSVCKGGDSGKAPFDRTSTRFDAVYYRELTSKRGLLSSDQTLFESPETKEMVSMFAMNPDYFFYAFQQGMLKMGQINLKEGDDGEIRHTCRVVNS | 14 |
Q8IE14 | 3.4.21.89 | ACT_SITE 63; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P67812"; ACT_SITE 101; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P67812"; ACT_SITE 127; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P67812" | MDFIKEQYNSLVLDLRKTFRNKRDGLSHILNVICLLLNALMIWKLLVVFTGCESPVVVVLSGSMEPGYYRGDTLALYHPPKIHAGDVVVYQINGRDIPIVHRILSLHTSKDNKFHLLSKGDNNNIDDRGLYDPHQYWLENEHVLGLSVGYTPYIGILTIWINEYPVVKWAIVSIMLIMILMGYE | 178 |
A0A3B6FYB3 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATSSSVVVLAVLATVAALVSPAMSLPVFTGDVGVSPGFHAASCPQLDGVVRSSVVAALRQEVALAAGLLRLYFHDCFPQGCDASILLNTTSARAGPVLGRGERGGRPGPPKARGPLPAGQQQDLSSLRPNNRVMSSTGRKYSSVSHKRKKEEGGRLMAIRKMMVILLQKAMLTSTWMIAIVAALVESFGTRGLGDVADLVALSGAHTIGRSHCGSFADRYRRADDTFSRKLAANCSKHPDRLQNLDVVTPDLFDNGYYKALRFNQGVLTSDMALVKNKTTAAIVKRFAQSKDAFFRQFARSMEKLARAPKPAGNVGEIR... | 14 |
Q5P7I0 | 1.3.3.3 | ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MGAPDSRVVRQHLLDLQSGIVAVLERFDGGRFREDAWQRPAGGGGITRVIEEGRFFERGGVNFSHVIGGAMPASATAHRPDLAGRTFEAMGVSLVLHPRNPYCPTVHMNVRFFIASHPEAAVPPPAAAPVWWFGGGMDLTPYYPYEEDVRNFHRACRAAVLPWGGEPEYRRLKEWCDRYFFLKHRNEPRGVGGLFFDDLGADGKTDFDAAFGLARSVGDAFLDAYLPIIERRRDVAYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPVVKWRYDWQPEPGSAEARLYDEFLAPRDW | 27 |
B8E0S5 | 2.7.1.11 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00339" | MIRRIGVLTSGGDAPGMNSAIRAIVRFGISKGIEIIGIERGYQGLIEGEFKVLSRDDVSEIVQKGGTILRTARSDEFREEEGQKKAIENMEKHGLDALIVIGGEGSLKGAYDLFKKGINVVGIPGSIDNDVWGTDFSIGFDTACNNVIDAINKIRDTAAAHERTFVIEVMGRECGFIAFTSGLVSGADIILIPEVPIDFPYITEKLRERQKRKKRHNIIVVAEGVGSAYFIGKQIEDKLGISTRIVVLGHIQRGGSPSVFDRNMATFMGVEAIKRLLNGEGGVMIGWQKNSPVPISLEEVSKYKKRVPPELYWEVECLW | 84 |
A0A9J7LW94 | 3.1.4.11 | ACT_SITE 266; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 302; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MFFCMHKYLANLPKDKLKEMVQFGPPDIPVENKTVTVVYGPDMVNISFINFVSNSEGVAKIWTDSLLKIATNVLALNASPMQNLKKVYAKLIVKDLTKEGKLPVKNVIKLFSTSKEERKRVEAALATCSLPTGKNDVINVEKFFFEDFITIVRKVCPRPELDKVFAEVGTKKPYLTMEQVVDFLNKGQRDPRLNEILYPYANNKKALDIISRYEPNKSYANKGHLSVDGLYRYLMSDENTMVDPVKFDLSDDMTQSLSHYFINSSHNTYLTGGTVCCSSLIWMSMCGAGLLDGNDNEPIITHGYTMCTDVLFKDVVEAIA... | 153 |
E3KAQ7 | 5.3.1.8 | ACT_SITE 308; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MSSPSPIVELIPQVQSYDWGKLGKDGSKVAEYSKHLPNFHYDPEKPYAELWMGTHSSLPSKLIDGKLLSDHLASDPAQLLGKQISNQYGSHLPFLFKVLAIGKALSIQAHPDRQLAIKLHKERPDVYKDDNHKPEMAIAITPFSGFCGFRPLNQISQYLEKVPEFATVIGQETSSRFLEAIPSDASMPSIISSTSTDQTDVKNYQAVLKELFGKLMNASSELVTEQVRKLIKRIEAEGGRDKPFGTDEELLLRLNDQFPDDVGIFCTFVLNVVRLEPGQAAFLQADEPHAYLTGDIVECMASSDNVVRAGLTPKLRDVPT... | 214 |
B3SA37 | 3.4.19.12 | ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 163; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MADDDGAGNWCLIDSDPRIFTELIKGFGVTGVQVEELWSLEKEEFEKLKPIHGLVFLFKWRPGEETVGSLVQDSRQIYFAKQVINNACATQAVLSVLLNCNHKDVQLGEMLYKFKEFSADFDPTMRGLSLSNMDIIRQVHNSFARQQMFEFENSSNKSEEAFHFVAYVPINGRLYELDGLKDGPIDLGKCGEDWITAVKPILESRMTSYATGEIRFNLMAVVSDHKMKLEADLEKLQSNLSDLEGKLSKLDTKKDTEAYLKLKNEYATVELKMNEANHQLRVEEEKRLRYKIEHAKRDHNYLPMIVQLLKCLAKDGRLVE... | 175 |
H2LLI2 | 3.1.4.11 | ACT_SITE 331; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 376; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAGAKPGVHALQLKPVSVHEDLKRGGKFIKWDEDPNGGSPTLVTLKVDPDGFFLSWTAGSNLEVEILDISTIRDTRTGKYARQPKEAKLQSMLSVGKDSFLGKSLTIVYGNDLVNISYLNFQAMSEDEAKLWTEELFSLATNILSHNATRNSYLLKAYTKLKLQVNQEGKIPVKNIMKLFSDKRRVETALEQCGLVRNKSEGIKPDDFTWEAFQKFLNNLCLRPEIQTIFEESSKKKPFISLDQFMDFLNRRQRDSRLNEVLYPPLKREQVRQIMEKYETNSSQLDRDQISLRAFSLYLGGEENGIVPPERLDIIDDMNQ... | 153 |
D8R0U5 | 3.1.1.11 | ACT_SITE 169; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MERERRDGNKLIQLEATVAKAVVSHDPDYGSHTSIQAAVDDAPDHLNRRYTIYITAGVYDEIVRIPSTKTMIAFVGDGINKTVITGNLSTVMGISTYRTATVAVSGNGFLMRDITVVNTAGPGGQAVAMRVDSDMAAIHRCSFWGFQDTLYTHAYRQFYRDCSIYGTIDFIFGNAASVFQNCNIQIRPGAANHTMSTITAHGRTDPAQDTAFVCQSCWISGTPEYLEARLAEPGKHQGFLGRPWKPYARAIFIESYLDVVIDPSGWLPWNGTLGLDTVVLAEFHNYGPGASPIGRVGWSKQLNTIAALEYSVRGLIQGGY... | 125 |
Q5A0H3 | 3.1.3.3 | ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MTYVLTAISHNDSKFETETLDSIKEFISNNFTLVSSKELSPRAIDYVISINDFESSKENVKEFSISKSFDLVIQLESSRKTKKLFIFDMDSTLIYQEVIELIASYADIEDKVAEITTRAMNGELDFNQSLAERVLLLKGIDASSIWDELKLKIQVTNGVPELCKALKKLNIIMGVCSGGFIPLAEFLKEKLGLDYAFANTLGIDDSNRLNGTTVGPIVNGEKKAELLLDIAKKHKIDPSDAVAVGDGANDLKMMFVAGFGIAWNAKPKVQKQAPACLNTKSLSDILYIMGYNDKEIKELID | 147 |
P38624 | 3.4.25.1 | ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:9087403" | MNGIQVDINRLKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL | 180 |
B9GXZ8 | 3.1.1.11 | ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLVAKMTQDKQSLTGISDSGKHISIFKKNKKLFLVILASLLLVTAIIAIVAGVNSHKSSKNEGTHAILKSSCSSTLYPELCYSAVATVPGATSNLASQKDVIELSINLTTKAVQHNFFTVEKLIATKKLTKREKTALHDCLEIIDETLDELHEALVDLNDYPNNKSLKKHADDLKTLLSSAITNQETCLDGFSHDEADKKVRKALLKGQIHVEKMCSNVLAMIKNMTDTDVANELKTTNRKLMQEKEGNESEWPEWMSVADRRLLQSSSVTPDVVVAADGSGNYKTVSAAVAAAPKKSSKRYIIRIKAGVYRENVDVPKD... | 125 |
A0A9J7N4H4 | 3.1.1.4 | ACT_SITE 72; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 120; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKVVLAAAILLVVGFGFEGAVGKPTRSVLQFGAMISHVTGRNPFDYLDYGCYCGLGGSGTPVDDIDRCCEVHDACYGAVDSSDGVGTAHLINYHFTQEAGGLVTCDDRFGTVAREACECDREAAFCFDRYPYPGRQPC | 130 |
A0A3Q2HRA5 | 4.1.1.17 | ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MRPFVTDFCHLKKILPFVTAWMDLEDITMSEIVTEDKYCMIKKHLRWLKALPRVTPFNAVKCNDSRTIVKTLADVGTGFDCASKTEIQLMLSLRVPPERIICANPCKQVSQVRYAANNGVQMMTFDSEVELMKVARAHPKAELVLRIATNDSKAVRRLSVKFGATLKTSRLLLEWAKELNIDVIRVSSHVGSGCTDPETFVQAISDARCVFDMGAEICFSVYQLDIGGGFPGSEEIRLKFEEVTSVINPAPDKYFASDSGVRVIAEPGGYYVASAFRLAVNIIAKKLILKEQTGADDDESSEQTFVYYVNDGVYGSFHCI... | 195 |
Q10452 | 2.7.11.1 | ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELR... | 99 |
Q8C6M1 | 3.4.19.12 | ACT_SITE 154; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 645; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MGDARDLCPHLDCIGEVTKEDLLLKSKGTCQSCGVAGPNLWACLQVTCPYVGCGESFADHSSIHAQVKKHNLTVNLTTFRVWCYACEREVFLEQRLAVHLASSSARLSEQDSPPPSHPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLISEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPMVAAVAALTDARDSDSSDTDERRDGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGSSKAEMELLISDEAGR... | 175 |
A0A3B6B876 | 1.11.1.7 | ACT_SITE 94; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MACSRAMVALMGLVLAALLFPAALSSRRPDQLISMTTDGQYHSTRPVVTIADGLTADYHDVSCPDLQGIVRTAVVEALQGDITIAADLLRMFFHDCFPQGCDASILLLGTPWSEMRMPPNLSLDIRRKVAFLMEDIRAKVHEACGPTVSCADIMALATHDAVIASGGKPYHVPLGRLDSFEPAPLRFVEELPPPTFSIGQLIAAFKSRSLDEKDLVVLSGAHTIGKAHCATFSDRFPNSDSDDFVRRLQDNCTADVNRRQDLDVTTPEKFDNKYYINLKQGKGVLTSDVQLLLNETTRGYVNDFADNEWWFWNQFGSSMS... | 14 |
A0A5F8GXA8 | 2.5.1.18 | ACT_SITE 16; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MANLPRKLELFYDVLSPYSWLGFELLCRYQNIWNINLQLRPSFIPGILKDSGNKPPALVPRKGKYMMMDLQHLKNFYQVPIRIPKDFLTVILEKGSLNAMRFLTAVNMEKPEMLENVSRELWMRIWSRDEDITEPWSIQAAAEEAGFSRKQAMSLLKKSSTEEVKNKLRENTNTAYKYGAFGLPTIVAHMDTKPCVFFSSDRIELLAHLLGEQWQGPVPQALKGKL | 77 |
H3GAG9 | 4.2.1.11 | ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 377; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSKPSLLQRTCWCLVCAFKSDLTFLANGSGRNHHLFLSIHAREIIDSRGNPTVEVDLTLSGSAEIFRASVPSGASTGIHEAVELRDGGKRYAGKGVQQAVQNVKSVLAPKLIGADPTKQRDIDNLMREIDGTENKGKLGANAILGVSLAVAKAGAAAKGVPLYQHFADLIGNKNLVLPVPSFNVINGGSHAGNKLAFQEFMLLPTGAESFSEAMVMGCEVYHQLKSVIKKKYGQDATNVGDEGGFAPNIQSNREGVELLMTAIGRAGYDGKIGIGMDVASSEFLTKEGKYDLDFKTEGSTDLLTGEELGQLYKDLAKEFP... | 200 |
Q9FX43 | 2.7.12.2 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MALVRERRQLNLRLPLPPISDRRFSTSSSSATTTTVAGCNGISACDLEKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRTDSPYVVKCHGIFEKPVVGEVSILMEYMDGGTLESLRGGVTEQKLAGFAKQILKGLSYLHALKIVHRDIKPANLLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSSDIYAGDIWSFGLMMLELLVGHFPLLPPGQRPDWATLMCAVCFGEPPRAPEGCSEEFRSFVECCLRKDSSKRWTAPQLLAHPFLREDL | 108 |
A8XUK9 | 2.7.11.1 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MSADVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDTLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKVSFRSIHRDIKGANILLSSNGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMLCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWSPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLGSLSARMTRDLLDKVNGAPSDVYDRMSKTVDDLTEEESDMD... | 99 |
A2DZQ0 | 4.1.1.17 | ACT_SITE 343; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MHHVAPHDNFTIIKNLDNTVQKCLEQMDNDQAFWIADFNRIRRSLALWEENLSRLHIHYAMKCCDEPELLKFLADRGVAYDCASEDEIRRILALGVDANRIVFAHPIKSIDSIKYAKENGVTRLVYDTESELRKILRYYPEAEVFLRIKPRFTHAKIQLSNKFGADPKEVPKLMQLASELGANFIGFSFHVGSLCDDITTFRVALEYVAELKAKAEQLGLNVSFIDIGGGFLPPSIKAKYTFAEIAEAINTAIDELFDGDEIEFLAEPGRFIASDFMDLVMPVICVKEHHDPDGDEQAVFIAEGIYGAFNALNYDHAEPH... | 195 |
A0A9R1WBW9 | 3.1.1.11 | ACT_SITE 372; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MARISKLFFPFILYVLFVCTSISWCLQEDGESDSDINYWCDTTPHPQQCKYFLSSGTHHTPRHRKDFRMLVLEVALQKAQEAQTCSNDLRNKCKSKRKKAVWLDCNKLVNQTILQLNQTLISFKHNQSSDFDAQTWLSAALTNLETCFSGSQDFNLTNFVSPLKSHNLTEMISNSLAINQFFLKQKSATNDDRELDNDFPTWVTPGDRKLLQTGSLRTKANLVVSQARGSKFRTIQSALKYAAGYNRRNRRYIIYIKRGVYKENIEIGNNLNNIMFLGDGARYTIITGSRSVGGGFTTYSSATVGVDGTGFIARGITFRN... | 125 |
A0A3B6LHZ7 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARPAPSPLLLLVVLAGALAGGGEAALLKAHFYRPSCPAAEAVVRDIVLARVAADPAALPARLLRLFFHDCFVRGCDASLLIDSTAGNTAEKDAGPNGSLGGFDIIDTAKAVLEAVCPGVVSCADIVALAARDAISFQFGRDLWDVQLGRRDGVVSSASEALSNIPSPSDNFPPSRPNSPARASTSRTSSFSRRAHHRRRPLQPLRQPPLQLHHHRCCPRHRPDPQRRLRHSAARRVWVALQQRHRRAYGPRQPCPVRLPLLRQPQARPWPVPLRRRTAADRRAAGMIHALTKEGYFLQEFKNAVRKMGRVGVLTGGQGE... | 14 |
F2DP54 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASRAAAALVVVAMACAVVHSAAAAAGELSPDFHAGSCPDLEHIVQYHVAEAFRKDVGVAPGLIRIFFHDCFPQGCDASVLLTGNNSEQALGPNLTLRPVGLNLIETIRAAVHRSCGRTVSCADITVLATRDSVVLAGGPRFEVALGRRDGLAPASQDLVFTLPAPSFTVPELLKSFGDRNLDKADLVSLSGAHTFGIAHCPAFSDRFTPEVDTNPAIDPNFAAKLKAKCANDVPALSVNQSLDVRTPDVFDNKYYFDLIAKQGLFKSDQGLIVHPETTRMATRFALNQGAFFEQFAKSMVKMSNMDLLTGSQGEIRFNC... | 14 |
Q8YZ37 | 1.3.3.3 | ACT_SITE 96; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MKQLQDEITQALTKLDGGSEFHEDSWERPEGGGGRSRVLRDGAIFEQAGVNFSEVWGSHLPPSILAQRPEAEGHGFYATGTSLVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHQTLKLACDEHHPEYYPVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGQGVLYRGPNPKGEAANYSNQVGEPASRDWEDLFSFIQGSGKAFLPAYVPIVERRHGMEYGDRQRNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYQPEPNSPEAELYDTFLKPQDWSNWTANQ | 27 |
Q8EDG1 | 3.5.4.5 | ACT_SITE 103; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01558" | MQDRFIRSITQLPTPLADALIPLLHQGFAGHIDAQHLAELVKSSNMTESEVLLALLPIAAALAKPPISEFYVGAIAKGKSGDIYMGANLELPGEALFHSVHAEQSAISHAWLSGESQIVDMIVNASPCGHCRQFMNELVDGGQIKIHLPSQDSHLLSYYLPYAFGPKDLNVQSPLLVKQETEFALDSSDPMVIEALDHAGLSYAPYTQSYAAVVLETADGATYCGRYAENAAFNPSMLPMQMALSNLTRHNRDFAEIRRAVLVESSQGKISLVGAAMDALHAVAAIELEHIVVDPI | 187 |
P83673 | 3.2.1.17 | ACT_SITE 84; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01257"; ACT_SITE 95; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01257" | MNGLILFCAVVFATAVCTYGSDAPCLRAGGRCQHDSITCSGRYRTGLCSGGVRRRCCVPSSSNSGSFSTGMVSQQCLRCICNVESGCRPIGCHWDVNSDSCGYFQIKRAYWIDCGSPGGDWQTCANNLACSSRCVQAYMARYHRRSGCSNSCESFARIHNGGPRGCRNSNTEGYWRRVQAQGCN | 160 |
B6TKH0 | 3.1.3.16 | ACT_SITE 289; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MDATANSDVQRAEEFKLKANDAFKANKFSQAIELYSQAIELNSSNAVYWANRAFAHTKLEEYGSAVQDATKAIEIDSRYSKGYYRRGAAYLAMGKFKEALKDFQQVKKICPNDPDATRKLKECEKAVQKIRFEEAISAGDDERRSVADSIDYHIIEVEPHYAGPRIDGEEITIEFVKAMLDEFKKQKCIHKRYAYQIVLKTLDLLRSMPSLVDVDVPNGGHFTVCGDVHGQYFDLLNIFDLNGLPSEENPYLFNGDFVDRGSFSVEVILTLFAFKCLYPKAMYLARGNHESKSMNKIYGFEGEVRSKLGEKFVELFAEVF... | 144 |
Q8GVN8 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQQLLAMKLILTTLVVAVLALSAGTATATCDTLTVGHYRQSCRAAETIVRDTVKLYFSKDQTVTAPLLRLHFHDCFVRGCDGSVLLNATAASGPAEKDAMPNQSLDGFYVIDAAKAALEKECPGVVSCADILALAARDAVSMAAGNINGASLWQVPTGRLDGRVSSAAEAVANLPSSFADFAKLKEQFGSKGLNVQDLAILSGAHAIGNSHCVSFAKRLYNFTGKGDADPTLDRAYAAAVLRAACPPRFDNATTVEMVPGSSTTFDTDYYRLVASRRGLFHSDQALLQDREAAATVRVMARSSRQAFFRRFGVSMVRMGN... | 14 |
P52034 | 2.7.1.11 | ACT_SITE 168; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03184" | MNSEINQRFLARGSQKDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGA... | 84 |
A0A0A0L1E1 | 6.3.4.4 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 109; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 209; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MNISSLAFEPTLFSAANLSPSSACRRPFSGRHPPLIVCSSAKTVAAVSSSVSVPESGRKDGLKRIGELSQVSGVLGCQWGDEGKGKLVDILAQHFEIVARCQGGANAGHTIYNAEGKKFALHLIPSGILNEDTLCVIGNGVVVHVPGFFEEIDRLEASGVSCKGRILVSDRAHLLFDFHQEVDGLREAELAKSFIGTTRRGIGPCYSSKVIRNGIRVGDLRHLDTLPQKLDLLLSDAAARFKDFNYTPEVLKEEVENYKRYAERLEPFITDTVYFINEAISANKRILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGL... | 253 |
Q26614 | 2.7.10.1 | ACT_SITE 781; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MSLPRCPRTRTVMFSRTLTRCYPQRTLWIAILCVICSWTLSTAGATTIRDKEVKPDAPQDLTAIPVKAEAIVLTWKKPLKGQTDGYIVVYCLKRNKGNGCERQKIEGGNVTEVEVTNLYANHTYQFQVQSWYSDHPKGASTGYIEASGTPPIPPTLRRNFKGLVEKSLGFEHKIPCPVKADPRPYTRWLKNGTDLTPNDPDDNVSFTKTSIVFKRLRFSDAGLYTCVASNFFGQPIHVNFTLIVVDTHSESYAESSVLESFSSLELETGPYNETEEEETHFPRFTDTERMEPEKPLPSNTKVRLECGARGTPTPNITWIK... | 97 |
A0A3B3I798 | 2.3.2.26 | ACT_SITE 763; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MSNQGVRRNGPVKVRLTVLCAKNLAKKDFFRLPDPFAKVVVDGSGQCHSTDTVRNTLDPKWNQHYDLYIGKADSITISVWNHKKIHKKQGAGFLGCVRLLSNTINRLKDTGYQRLDLNKLGPNDNDTVRGQIVVSLQSRDRIGTGGPVVDCSRLFDNDLPDGWEERRTTSGRIQYLNHITRTTQWERPTRCPEAVRDGEETGNGDKYRPASEYSSPSGRPSSCVVDENTPVMTPVNGAVASCPLGEQRVQERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNVNCEELGPL... | 65 |
Q5AUW5 | 3.2.1.21 | ACT_SITE 324; /evidence="ECO:0000250" | MRVPSLSVLSFLLGTALAAASNFEAGLLSSGKVSLGDWKSAHEKASQFVAKLNTTEKIKLITGSSVTTTNGETFTALDILDGDMGAQAYYYVSAFSLSSALAMTWDKEAMYEQGRAIAAEFYGKGIQMVAGPTSQPLGRTPWGGRLVESFGPDPYLNGIATGLETRAYADVGVIAGAKHFILNEQETNRTGGMGGGGGAPGGGGMGRGAEFSSSVPGGMSPTSSAGAIPSSTSTPGGSGMGGGMAGSSAFSSSSSSGAPYSSNADDKTLHETYLWSFYDAVHSGLGGVMCAMTKVNGTLSCQSSSLLLDILKTELGFPGM... | 161 |
A7T196 | 2.3.2.26 | ACT_SITE 728; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MVPESKYRFHNRHCLAKKGLQIYLFGHYLQPRFTKVKWEWQDPQVVGETLTFLLQIRHNYTPFTVKRTDIDIEIVHDGTPIACSLDFGGPGWQEMNRVKVTFTVRKSGDYNIAVLAMGEHITGSPFAKVFLPGSVDPAKCTIIERSSILVLQQGVYSPLLVEARDVYGNLRSISNAEDLLKYKVHIKKIGGSDSIDPELFVDSENRSNNSLHIKLEDEGIFQGTVSYDGTPVNNGELTIISLNDSEWYAVEKNIDRHCYNVWYEAALLPYPLTGSNTPPSIGNGADVARKSRKVYCYISPRNVSIKEFYMRIFPHKLHAF... | 65 |
B9I6Y8 | 3.1.1.11 | ACT_SITE 198; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQKPLFNAIVIILFITISSSNSQAIDCKPGRGKRVRKTIVVDHSGKGHFIKIQDAIDSIPINNDQWIKVRINPGTYIEQVTIPEDKPCIFLEGRDRTLTTITYNAHESTDTSATFTSSPSNIVAKGITFKNSYNLPFKQNINYGIKIPGVGVAPALSARIYGDKSAFYDCAFLGVQDTLWDVEGRHHFFNCYIEGAVDFIFGAGQSFYEGCSINVTSKGVITAQGREFPNDPSGFIFSGCTISGIEGVRAFLGRAYRPFSRVIFQDSYFSKVVDPLGWNAWGYAGQEENFTYVEVDCKGPGSNKSKRVPWVRKPSTGQHE... | 125 |
Q8ZEH0 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MERYQQLFKQLAAKKEGAFVPFVQLGDPSPAMSLNIIDTLIAAGADALELGIPFSDPLADGPTIQNAALRAFAAGVTPGICFEILAEIRQKHPTIPIGLLMYANLVFHNGIDHFYQRCAEVGVDSVLIADVPFEESAPFRAAALRHGIAPIFICPPNADDDLLREIASHGRGYTYLLSRAGVTGAENHGQLPLNHLVDKLREYNAAPALQGFGISEPAQVKASLAAGAAGAISGSAIVKIIEKNVAQPVEMLVQLTRFVTEMKAATRS | 202 |
A0A1S4H697 | 3.1.3.1 | ACT_SITE 143; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MRDLARYFACFLAFALTAGELVTVPGAREPDGHSRRGKDGSFKSSAASSRTQTPQVQGFQERELETDYWLEQAQQTLAQKLATPHNTDHAKNVIFFIGDGMSSQTVAATRMYLGNEANFLSFENFKDLGSVRTYCVNRQVSDSSCTATAYLSGVKINYGMVNIAASVDRYACEYDRNASDFEGLLKWAQDAGKSTGIVTTTKITHATPAGAYASSANRYWENDVEVASSDCDPSRVDDIAEQLVDKEVAQRFNVVLGGGRGNLLPKETMDEEGKPGYREDGKNLIEQWKQTHETMGRSQYVWNREQLMSVDTANTDYLLG... | 141 |
P73411 | 1.1.1.49 | ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00966" | MVTLLENPFRTGLRQERTPEPLILTIFGASGDLTQRKLVPAIYQMKRERRLPPELTVVGFARRDWSHDHFREQMRKGIEEFSTGIGSEDLWNEFAQGLFYCSGNMDDPESYLKLKNFLGELDEKRNTRGNRVFYLAVSPNFFPPGIKQLGAAGMLSDPVKSRIVIEKPFGRDLSSAQSLNRVVQSVCKENQVYRIDHYLGKETVQNLMVFRFANAIFEPLWNRQFVDHVQITVAETVGVEERAGYYESAGALRDMVQNHLMQLFCLTAMDPPNAIDADSIRNEKVKVLQATRLADINNLENAGIRGQYKAGWMGGKPVPG... | 6 |
P55799 | 3.1.3.16 | ACT_SITE 78; /note="Proton donor"; /evidence="ECO:0000250" | MPSTRYQKINAHHYRHIWVVGDIHGEYQLLQSRLHQLSFFPKIDLLISVGDNIDRGPESLDVLRLLNQPWFTSVKGNHEAMALEAFETGDGNMWLASGGDWFFDLNDSEQQEAIDLLLKFHHLPHIIEITNDNIKYAIAHADYPGSEYLFGKEIAESELLWPVDRVQKSLNGELQQINGADYFIFGHMMFDNIQTFANQIYIDTGSPNSGRLSFYKIK | 144 |
F6TY81 | 3.2.1.35 | ACT_SITE 148; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPIIPNVPFLWAWNAPSEFCLGKFNEPLDMSLFTLMGSPRINITGQGVTIFYVDRLGYYPYIDLTTGVTVHGGIPQKVSLQDHLDKSKQDILFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLPQATDKAKQEFEKAGKDFMLETIKLGRSLRPNHLWGYYLFPDCYNHHYRKPGYNGSCFDVEIKRNDDLSWLWNESTALYPSIYLNTQQSVVVATLYVRNRVREAIRVSKIPDAKNPLPVFVYARLVFTDQVLKFLSREE... | 166 |
F6HDK0 | 4.1.1.50 | ACT_SITE 64; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 78; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 237; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVSGFEGFEKRLELHFSGDDPVVGMGLRHLDFESLEQVLHAVQCTVVSAVGNHYFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSIPPLLHHGRHLGLAMCGCRYTRGSFIFPKAQPFPHTSFRDEVIYLEQSLPSTLCYRKASVMPSKMSSHSWHVFSASDEPHMVLQHMPDVLYTLEVCMTDLDRVLARKFFLRPGAGKAGDVAGKEMTELTGIGDINPGALICDFAFDPCGYSMNGIDGDRYSTIHVTPEDGYSYASFECVGSIYDDQNDVVQVLKKVVQVFRPATMSVSTTCTSHEVWTRVATALEPMGLKCRSC... | 196 |
A0A3B6ESG4 | 1.11.1.7 | ACT_SITE 97; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVCARTASAPLLAAALVAALAVACSLVSGAYAAAEQEAAGAGGNDLRLRQPPITRGLSFDFYKRSCPMAESIVRDFVRDAVRKDVGLAAGLLRLHFHNCFIQGCGRARVMHACRAATGPGEQRAPPNLTLRPSAFKAINDIRDRLERECRGAVVSCSDILTLAARDSVVATGGPEYRVPLGRHDSPRFATPQDVLSGLPATTSAVPSLLDVFHNHSLHLDATDLVALPGGHTVGLGHCVSFEVEFPQAVDPTMSPDFLGRLKRTCPAKGTDARTRDVRTPDVFDNKYYVNLVNREGFFVSDQDLFTNEATRPIVERFARS... | 14 |
A0A022RI95 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAALTNSHAVVIIGLLLSCFILFVSAADDNSTAALTVGFYKNSCPFAEIIVRKYVNKFVTFNPGFAAGLIRLHFHDCFVRGCDASVLLDGKNSEKQSIPNKGSLRGFEIIDAAKAELEVKCPGIVSCADILAFSARDSAWKAGNIFYEVPAGRRDGNVSNTLDPLLNLPPPFFNATQLRDNFARKGLTLDEMVTLSGAHSIGIAHCTSFLGRLYPTVDPTLDPKYAAKLKKICPAPVANATGPPKVNPTVNQDTITPIRLDNLYYLGLKQKKGLFTSDQDLMTSPLTSNIVLNNIQFGGVWATKFAAAMVKMGNIDVLTG... | 14 |
Q8Y4G7 | 5.1.3.3 | ACT_SITE 182; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 317; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MIFIEVMKERFGEFEGETVWKWTMINDHDMRMSVLNYGAIVTSLETKDKFGDFANISLGFTNLDDYLAHSPYFGATLGPVAGRITNGQFSLDGKQFQLIQNEGSNHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGKIDAKMTYTLNNKNEWLVDYEARSNQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEITQSQDQQVKLVGAGLDHTFILKHENGRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIDERAVPKYAGITMETQG... | 211 |
A0A0K9NVI2 | 3.1.1.11 | ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKSAKLTILAATVAFLLLLGVIVVCAIQYKSGESEDKKKDNEEASEIRLHAQSKQVKEMCSVTEYDHVCVVSLSNILKQTNLSNPQTKDLMRGAVIVVSDEISKVWMKSKLIKSDDPNVKGAVQDCEGLFRHAKKELLSSIQAMNIQGIEELPKKSPEIKNWLSAVLSYQQTCVDGFPDGTIKNKMQNIVKLSKELTCNALAIIDKVSSILEDLNLSDVVNSPTQRTTTGRVLPEWLDGDDRRFLMGRHTKKMKPNITVAQDGSGNFTTIVDAIAAIPYEHEGRICVYIKRGIYTESPILMAPNVTFYGDGSRKTIITGS... | 125 |
A0A061GWC4 | 3.4.19.12 | ACT_SITE 18; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 128; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 143; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MASEQNQIYHERQRLQYCLLHSLNNLFQQKDAFTRASLNSVAEKLVLDDPNKEIWTPFSLVFKPHHNSITGNYDINVLIAALEGKGKTVIWHDRRNGASAIDLNDEILMGIVINVPVRRYAGLWKSRHWIALRNIDGVWYNLDSDLDAPQCFKDSGEVKDFLDYIITHDGQLLLVKNDRQVCKRKESILQIESLVRKVTQGSNKVSRKKGNNKVNASAMQKSDNKAAGNRGVTRSCGFMLCKRSKFSPVRFLKHLGGKVAKGLHVVSMRIRPSPKVSSSSGRSKPFVTPVDSHRSAAIEDCIEFINSSASLPRSNSVSAN... | 175 |
A8WNQ8 | 2.3.2.26 | ACT_SITE 996; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSFNLVFFNGDVRRDKKQEAMLNSMVRRGKSRKMKNLAEKIEKNIQNLKIFERKFGTLNENFRLNARGNFLQSLADMEKQRTKNEEQTKAVRKIQKKWRGFRARHFLRLQFRAQFDAISDGHRGLENSNYLNFQKILQMAQLLVNFYETNKDEERLVMTLVELVKARTANRAFEQQIRDSQRFLLARCCVKFLDHADENTIFFHVFRFLEDFVTCHSHLYEAISQHGLFDAEFHLLEALIGKPEDVSIQKKPILPRHLQLLTRIFDVFVFQNPARTTPVSVHVADRLLKTICVKISDLNFANYILYYIRDHIRLSGTQHV... | 65 |
A9V4T8 | 2.3.1.48 | ACT_SITE 678; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MGQRRMAAVAVMVVLLAGLQPAVMDIVTTLTTTTINNLKCQCTNASLFSPNEQIAACRKAKLIETVDTLINATFETRLAALEAVAFGDGCEPDAYSGTSPIVLTTNPPPLNLTLCDAETDMFEYTLPESGVYEVYLSPIDDVVSCIMPFVKVSFLLNNMPIQFDNMTTDGVKVTFTSPDPVSGTIKFLIESNQTVPCACALPLCLLIHSSIPLSVSLSLSLSLSLSLSLYFSFSNRPNQFISLSLSLSLSLSLSLSLSLSLSLSLSLFCDRYNPRKPIARAWKCIRCKTCMRCHKKGNADQLLFCDGCDAAIHTYCCRPK... | 61 |
A0A251VH87 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATHKLLCNLSFIFLLFFQFHFGTSEIRLNYYSETCPNAEEIIKEQVISLYNKHGNTAVSWIRTLFHDCMVKSCDASLLLESINGIQSEKISSRNMGMRNFKYINTIKDAVESACPLTVSCADIVALSARDGAVMLGGPCIEMKTGRKDSKESHLAEIDASLPNHNDSMMYVLARFQSIGIDVEGTVALLGAHSVGRVHCVNIVDRLYPTVDPTLDPNYAEYLKGRCPHPDPDPIAVEYARNDRDTPMILDNSYYKNLMNHKGLLTVDQELVSNPITSPFVEKMAADNDYFHEQFSKALLILSENNPLSEEEGEVRTDCR... | 14 |
P00334 | 1.1.1.1 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000269|PubMed:15581900" | MSFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKHWDSGI | 1 |
F5HB11 | 2.7.11.1 | ACT_SITE 311; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 328; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MASQPELTSTTAATDNQNVDLSNTTAQLNNLAIEEEDDDDDLQDVFESDDDLDYEDGGTDLTKSYNRQQHGAGATNSQQSQAQAQQQKPTANTSARVDDQIAALSKFAGKIRIDAFDNASGPAERSKDKSDRATSELVLDQRTRMILLQMINQGFVSEIHGAISTGKEANVYGAILHPEDGSAPIHKAIKIYKTAILVFKDREKYITGEHRFKSGSEKGNNRKMVKLWAEKEFRNLRRLYTAGIPCPEPIKLKLHVLVMSFLGDRKGWAYPRLRDAPISGDDADEQWRDLYIQLLGLMRKLYQVCRLVHADLSEYNILYN... | 99 |
A0CQX5 | 2.3.2.26 | ACT_SITE 1144; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTATFVDQINFEFISIAISNTTKHRIIRINEDNFVVDPILTLPINTACYFESNAKSYKLQGQLNNFLKQHEEFKEVFLIFDDELDNQVHRAADRIIAENLGINNFIKGYEQFISNRNQNSINSQLQMYFGVQSISSIKISITKNLINKIEFIFAPLKHEGETLIKLKDQTLQVYSLLGENNIIYPEIDEVSFFFYNLIINFRDHHLESQITNDNQIQINFKRQPDLEFIYAFVDITLIAQYIHKLVCIIDKENEIKAINIQHTDEITTNNKYSLYSFVDDMIIFNYCKYYEFMFSNFILDYLNRKQINQIYKINQNITYS... | 65 |
A0A0P0X9S3 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | LRRSTMAAARVAMWVACVLAMAAACQGRLRVGYYKRKCAPAEYVVRAVVGNAVRQNPGVGAGIVRMFFHDCFVQGCDASVLLDPTAANPQPEKLGPPNFPSLRGFEVIDAAKAAVEKACPGVVSCADIIAFAARDASFFLSGGGISYRIPAGRLDGRVSLANETLAFLPPPVFNLTQLVASFQAKGLDADDMVTLSGAHTIGRSHCSSFADRLSPPSDMDPGLAAALRSKCPASPNFTDDPTVAQDAVTPDRMDRQYYRNVLDRKVLFDSDAALLASRPTAAMVARNAAARGRWERRFARAMVKMGGIEVKTAANGEIRR... | 14 |
A0A3B6H2L0 | 1.11.1.7 | ACT_SITE 97; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVCAWTASAPLLAAAVVAALAMVCSLGSGSYAAAEQEAAGAGGSDLRLRQPPIRRGLSFDFYKRSCPRAESIVRHFVRDAVRKDIGLAAGLLRLHFHDCFVQGCDASVLLDGSATGPGEQQAPPNLTLRPSAFKAINDILALAARDSVVATGGPEYRVPLGRRDSPRLATPQDVLSGLPAPTSAVPSLLDVFHNHSADLDATDLVALSGAHTVGLGHCASFEGRLFPRPDPTMSPDFLGRLRRTCPAKGTDARTALDVRTPDVFDNKYYVNLVNREGLLVSDQDLFTNDATRPIVERFARSQRYFFHQFGVSMVKMGQIR... | 14 |
P53349 | 2.7.11.25 | ACT_SITE 1350; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEVNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPN... | 105 |
P0DO50 | 4.2.1.1 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01134" | MKMINSIFTHGSLIILLLLFHSISIKAQEVDDEREFDYLEGSELGPEKWGELRPEWGTCKRGKMQSPIDISNPVQVTSKELLQTKYKAQNAIINNRGHDIMVRWEGDAGSILINEREFDLLQAHWHAPSEHAINGTRYAMELHMLHRSTDPKLTPTMVVVAVFYEIGDVDPFLSRLGPIMSSLIDQTNEHKQAGVINPMEIQLDDECYYKYIGSLTTPSCTEGVTWIINKRINTVSSDQVKLLREAVHDHAKNNARPLQALNHREVQLHCHKDRKD | 199 |
A0A7M7RAI1 | 2.3.2.26 | ACT_SITE 752; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAVSMAGQICAACETTFSQGLQSQRVACPSCGRKLVGRVAAPMHPMQATRDRGNSGASLPPLSNPSSPTNEEHARSKFSGISNFFSNLGTKEKGKSAEKRSKEKLPRITPGQAMVSQNGARKIHTPDTQVAPGFKPITLQEFKSDVEKSKATKDTKILLKYFESTFLSFAHINVTFKDPVKNGKSLEDCGLVQEYIDSVYKCLLETTVEIQKITLKGIINSLLKDLKKPRDKNDLRAYLVLIQNPQFDKTSTFVIFAHLLRQLSTLADNDHHYMVHWFKGLPAANFKSIVERLQQFTSVRLFPPKSNELPPVGKCSWWIP... | 65 |
B8DZY1 | 2.7.6.1 | ACT_SITE 194; /evidence="ECO:0000256|HAMAP-Rule:MF_00583" | MGQRCLALYSGTSNRELAEEVAKYLGIELGEIEIRRFSDGEIYARIAKSVRGAEVYVIQSLGSKVNEYFMELLIIIDALKRASADEVTAVIPYYAYARQDRKTKSREPISAKLIANLLTVAGASRVVTMDLHAGQIQGFFDIPVDNLSALPLFTRYFQDKNLKNPVVVSPDIGGVTRARALADRLHTPLAIIYKRRPAPEVAEVEEIIGEVEGRDVIICDDIVTTGNTLFSAAKLLKLKGARDIYAAVTHGILTNDAHKKLQESEIKELVVTNTIPIPLEKRVPKLTIISIGNLLGEAIKRISNKDSLSSLFD | 114 |
A0A1S3Y597 | 2.3.1.181 | ACT_SITE 186; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MTDCSMIYRRMRRSVEVWKMGTVNYLEALKLQEKLASDRKALKITDTLLSLQHPPTYTLGKRQTVHNLLIPDSELKAMGVELHYTQRGGDITFHGPHQAILYPIVSLRDIGLGARTYVEKLELTMIELASIYGVKAQVGKRCETGVWVEDRKIGAIGVRISSGITSHGLAFNMDPDLNYFKHIVPCGIADKDVTSLKKEADVELPAEEVIQEQLIACFVRIFGYNDVILKDKSVL | 55 |
D2A3C2 | 3.1.3.1 | ACT_SITE 127; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MFVAITVLCLLVPSQLAAVIKNENLFQYINPTPDNELLREDKQFWYDVGNNYLEKNLRYDHESTTKVAKNVVILIGDGMGISTITATRIYKGQRSGKSGEDHTLAYDNFPNVALVKTYNVDMQVPDSAGTATALFTGVKTRYEAVGVDVNCNKTIADRTVFEASKLEGIMTWAQQANKSTGIVTTTRITHATPASTYAHAHYREWECDSEMPQEFKPFVKDIARQLVEDAPGNNFKVILGGGYQQMGHIFEDLSDGECVRNDTLNLTQTWIDDHKGLKASFVTNNQQLENVGDVDYLLGLFYPDHLPYELLRNKGLDGTP... | 141 |
U5CPU8 | 3.1.1.11 | ACT_SITE 240; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MENLMRILILILLLCFGLEQGQAKSLRKLQPPKILINFPENGTKNQLIEDQFMMWVEWVGSLKHSLFGAAINKIFPSFYLTVDKNPAKGDFTTIQSAIDSLPFINLVRVVIKVNPGTYTEKVIIPAMKAFITIEGAGADRTEVQWGDTAQTVGPTGQPIGTFNSATFAVNSPYFIAKNITFKNTTPVPKPGASGKQAVAFRISADTAAFLGCKFLGAQDTLYDHVGRHYYKDCYIEGSVDFIFGNGLSLYEGCHVHAIANNYGALTAQNRMSLLEDTGFSFVNCKVTGSGALYLGRAWGAFSRVVFAYTYMDNIIIPRGW... | 125 |
P30290 | 2.7.11.1 | ACT_SITE 417; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDSSTTIPITPTRTPCFFNISSSFNEHSPLNFYDEPIYNFSSGHEENQSHKSSKLTFFKPSNTKRSPHTPMQNNAKAIRLSTTVRHGIFKNSDLDGCSKPFAFSSGLKLSKKIVDASTPIDLKRKRAVTSLSTGLLSKREKWSLWEGNLTNPRSEQPHTPCKKGTKIKLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDETFEMEELPSLSYGSEDLLEFCETPCKSQPIFLSSSHVNNWDEKDVPSSLSWTPTSPIFLNINSADDYEEEEDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPTETVYVVK... | 99 |
A0A6P9E9T8 | 2.3.2.26 | ACT_SITE 1496; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGNRGQKRAEMVDELPADKRACSSLDFRPSSSNSSVQTHMNSPNSAHETRDNDMETSSSASASSRSEGEPERDSAYGSCDSDDAEQRHSNLRHYRDYQRQRSSTDHGKFKRILSSLSEETGPSEQLASLTELCEVLSFCTQDSLSSMVSDSLSPLLVNLAKHESNPDIMLLAIRAITYICDVYPRSSNFLIRHDAVPALCQRLLAIEYLDVAEQCLQALEKISREQPLACLQAGAIMAVLNYIDFFSTSVQRVALSTVVNVCKKLPSECPSSFMKAIPILCNLLQYEDRQLVEYVAICLIKIVERVSQSSELLDELCKHR... | 65 |
A0A8M3BCL4 | 2.7.10.1 | ACT_SITE 831; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MKLASSLCCLGFLLTSVAVRLSDSQQVCTGTENKLSTLSDLDQQYRTLRKYYENCEVVMGNLEITSIDRSRDLSFLRSIREVTGYVLVALNQFEYLPLENLRIIRGTRLYEDRYALAIFLNYRRDGNFGLRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWQDIVKNARPDHLVVPSNSSSSCQRCHRACNGRCWGPKEDQCQSLTKTVCAEQCDGRCFGPYVSDCCHPECAGGCSGPKNTDCFACTNFNDSGACVTQCPRPFVYNPTTFQLEHNPWAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENRIKM... | 97 |
P44334 | 1.1.1.205 | ACT_SITE 306; /note="Thioimidate intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964"; ACT_SITE 402; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01964" | MSLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDLVTVKEGASREEILELMHQHRVEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVKAGVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQIT... | 3 |
A0A2R6W6I4 | 2.3.2.26 | ACT_SITE 1005; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDFFSGDPSSRRKVDLGGRSNKERDREKLLVEARLEREQRKLVRLHNQSAAQIQKCFRGRKVVAVARPAIRSEFCSQFGEFGEKADSTVFRSSSKYFPQLFFFFNEKDAGDCQRLVQACRLLQQSLRETGDVVALFTENDQIDGPLVIYRVKRLARICLQTLHVHRNSLKAELLQPVQAFNSLTNSATLLLDTVLTLTGDNFPWSEVVLKYLHEYKLFYLLRSIFLMVEPEEKPTKMTCIESAVLVFASRHVRSLRSDTSKLTKGSFSTDILSIPLVWKRFPIFKQECIKEKVWAHSVHQIAASLSELLSILPPDTCPGF... | 65 |
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