Entry stringlengths 6 10 | EC_number stringclasses 260
values | Active_site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
O67088 | 3.4.21.89 | ACT_SITE 32; /evidence="ECO:0000250"; ACT_SITE 75; /evidence="ECO:0000250" | MRKQIVELFLIILAVLFIREYIAQAYTIPSASMEPTLLVGDFILVNKLVYSLSEPMRGDMIVFKYPKNPDIDFIKRIIARGGDTVEFFPYYDEKNNVLIYKVAVNGKLYELTYEGEKNYSYDCYQYREKLYREDGEVIQHSVCFRNTLLKVPGMVYNAISSDLCLKYNEDGFCVKFVVPEGYYFVMGDNRDNSQDSRFWGFVPRENIEGKAFVIYYSGKVPSLTPEEANPLTAVRQIIYALLNPRPSRIGKPLIDK | 178 |
A0A1S4GZ32 | 3.1.3.48 | ACT_SITE 532; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 534; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MVTLMPCSYISASRISIIDKMIEIEPKGKRSRLEGPDTTTERSRLYSNLADSSPLGAATTAVSATLDTIGAGPALALGTPFHYPPGALSAHHTTGSEHTVFNHAGTGTTSTTSTPYRASNTSGGSLSLHNGLTLSYGTLGSAASPVGSSLTSRLNNSAGSSGSSSSSSNSSSTVVSTGTVSSGGSSAGSSTAGLVDGLSTLATGSSSSSSLVGPLLTTGGGVATATATTAAAAELGMSHWLSDGTVKSELRSPGLDANHLAASATNLPLGPATAAHHLDGTGLFCANPGTTAVATAATLDALQSQSAAAAATNVYDHKSD... | 149 |
F7BZN6 | 3.2.1.23 | ACT_SITE 174; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 254; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | GALTDSLWCLSLHTNRTFQIDYERDQFLKDGKPFRYISGSIHYSRIPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPLPGVYRFSDDYDLEYFLQLAHEIGLLVILRPGPYICAEWDMGGLPAWLLTKKSIVLRSSDPDYLAETEKWLGVLLPKMKPYLYQNGGPIITVQVENEYGSYFTCDYNYLRFLQQLFHKHLGEEVVLFTTDGASEDYLKCGTLQGLYATVDFGTNHNITEAFQSQRKTEPKGPLVNSEFYTGWLDHWGEAHETVDTKAIISSLNDMLSQGANVNMYMFIGGTNFGFWNGANIPYAAQPTSYDYD... | 163 |
Q813Z9 | 5.4.99.12 | ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MHNYKLTIQYDGARFKGWQRLGNNDNTIQGKIESVISEMVGKEIEIIGCSRTDAGVHALNQVANFQSDEKLVEHKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWNEEHTNPFMRKYSMHVNKKLNVKSMKAAAKHLVGSHDFTAFSNAKSKKKSMVREVYTLDVMEEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLDAEAIPNILEEKQRNQINCLAEASGLYLENVEF | 217 |
Q2G0S2 | 2.7.6.1 | ACT_SITE 202; /evidence="ECO:0000256|HAMAP-Rule:MF_00583" | MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLF... | 114 |
Q66GN2 | 2.7.11.1 | ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGRAKSMVSLLLVLFLVRAHVATTETTTEFIFHGFKGNQSEIHMQGDSTITSNGLLRLTDRNSDVVGTAFYHKPVRLLDSNSTNTTVRSFSTSFIFIIPSSSTSNGGFGFTFTLSPTPNRTDADPEQYMGLLNERNDGNSSNHVFAVEFDTVQGFKDGTNRIGNHIGLNFNSLSSDVQEPVAYFNNNDSQKEEFQLVSGEPIQVFLDYHGPTKTLNLTVYPTRLGYKPRIPLISREVPKLSDIVVDEMFVGFTAATGRHGQSSAHYVMGWSFASGGEHPLAAMLDISQLPPPPPNKAKKRGYNGKVIALIVALSTVISIM... | 99 |
Q4X262 | 2.7.11.1 | ACT_SITE 243; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MATKALEARFEHLSVKDDADHGRNGSTYSKHKGSLSTAVSLSGLGAAGQFNSGSSRSTLLKLALQNTNENKVNAMHTGSSPLKGAQSTLAHRDTDENGESRHTTPLYEQPGPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPNPQDNYYSEKVDLWSLGVLTYEFLVGEAPF... | 99 |
A0A9R0IKM8 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAVSFSYGSYHFRLYVLPLGFVLMTLVSHFYAHDLRIGFYNGKCGGHNIEKFIYGVVKNKIVEDPNVVSDFIRLSFHDCFVRGCDGSILLEGKHTEKTARVNKRVGGIEDVGDIKKAVEKVCPRVVSCTDVLVITTRAAVFLGGGKWYDVETGRRDGRVSLSKEAEATLPPPTIPVHKAIQLFAKKGLNKRDFVVLLGGHTAGTAHCHSFKKRLYNFHNTHKPDQTISSPLLRVLRKMCPLHSQSDKEAFLDQTPNSHFKMDNGYYKQIVAHNGTLEIDQNMALSPLTRGIVKGLANSPYQFVNEFGPAMVKMARIGVLT... | 14 |
W1NL96 | 3.1.1.11 | ACT_SITE 392; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGSLVLHLPLRIAFLSTIFSLLTYQVHPVSLSNLSHPQLESLCKSTPFPSRCFDTLKLSVSINLPNILDLAKQTLQNALSEATKTTNLVMGLRQYGLVERERGTIQDCQELHQRTLDFLQSSLKIGNPKPENLNKIRTLLSAALTNKNTCFEGLDSASGSIKPTLMSKLNSMYELVSNSLSMYSNPSKSQGRQGRRLLEDSGRRKSGFPARFSRKRGFPAWLTGKDRRILQSSPGDGYDSGDILIVAKDGSGNYSSIMEAVNAMPNNRLDRFVIFVKEGVYEENVEIASNKQNLVMMGDGIDVTVITGSRSVGDGWTTFR... | 125 |
Q24216 | 2.7.11.23 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MLPNANDKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAKEGA... | 103 |
W1PJK7 | 1.11.1.7 | ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDLQLFLLPFFFLSLVNAQLRFNFYNSTCPNAESIIKSAVTNRSNTDPSITAALLRMHFHDCFVRGCDASILIDSTTKHKSEKDAGANQSVRGFELIDEVKTALEKECSNIVSCADIVTIATRDAIALSGGPAYAVPTGRRDGRTSNPNEVNLPGPTLSVLQAFSFFQAKGFTLKEMVTLLGAHTVGVAHCLFFRDRLFNFRGTQKPDPSMDPDLVSKLQRQCGRNNLPIATDPTAFLDQNTNSTVDNEFYNQVLKGKGILLIDHNLGADNSTVGFVKQFGGDANGFLQDFKAVMVKMGSLNVLVGNAGEIRKNCRVFNA... | 14 |
D7TAA8 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQSSTFRLAFLVVLISVLLSLRDPSKGEPQNHAIHGISPPKLDHQPSLEYDFYRNSCPKAESIVRSSMAQIFAAHSDTPPALLRLLFHDCFIQGCDASILLDDSNESTNRSAEKLAIPNQTLKGFDKVEKIKEELEKACPGVVSCADILVLATRDGIVLAGGPFYPVFTGRRDSNQSYFQEAMDDIPKPDGNITQTLGLFTLRGFNERETVSLLGGHSIGKISCEFIQGRLFNFSGTGQPDPSIASDFLDEMRRNCQDSGNSSNGTASPPMVSRAMSELTLGMTYYQGLSSSVSSGSAFDTHYYQSLLQGRGLLFSDQQL... | 14 |
P00929 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; ACT_SITE 60; /note="Proton acceptor" | MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQCFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDDLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQMLAELRSFVSAMKAASRA | 202 |
A0A3B6RBY9 | 2.1.1.33 | ACT_SITE 181; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MPNPDEAGGEPDAAPRGLGQMTRTSGANGGGQQGSGKLPRKRFYRARAHSNPLSDSHFPIPISPDDVDLSQHYPRYFPADKGEHGDGDGDAEAPRIRFADVGCGFGGLLVGLSPLFPDKLMIGMELRDKVTEYVKERVLALRASNPGQYDNISVVRTNSMKYIPNYFGKAQLSKMFFLFPDPHFKEKNHRRRVISMHLLDEYAYVMEAGGIIYTITDVEELGIWMRTCLEKHPLFGAVPEEEIKVDPVVKLLSSATEEGQKVARNGGQTFQAIFRRISLQEE | 45 |
H2M5S7 | 2.7.10.1 | ACT_SITE 783; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MMGKDRRGVMPGCAWVVILVCVIPSVCAVEETVMDTRTATAELGWISFPANGWEEVSGYDENLNTIRTYQVCNVFEPSQNNWLLTTYIDRRAAQRIYVEIRFTVRDCASIPNVLGSCKETFNLYYLETDRRETAGNRGVEYWANAPFLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLSKGRGFHLAFQDLGACMSLLAVRVFYKKCPSIVQNFAYFPETLTGAESTSLVIARGSCIENAEEVDVPIKLYCNGDGEWMVPIGSCSCKAGYEPDSSNVCRACPQGTFKSSQGAGLCQQCPFNSRSTIEAATLCGCRNG... | 97 |
W1NKE3 | 4.1.1.17 | ACT_SITE 365; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MGSDQLGAPSTRTLQAVISSPHIRNKRLWPLSKCSKGGVSDLVQTIIKKQDAKDPFYLMDMGSLASLWDRWQEVLPTVRPFYAVKCNPEPALLGAMAALGAGFDCASRAEIESVLAQGVSPDRIVYANPCKAETHIKYAASVGVNLTTYDSKDEVEKLRRLHPRCALLLRVKPPDDAGARCPLGPKYGALPEEVVPLLQAARSAGLSVTGVSFHVGSGAAHARAYTSAIAAARAVFDSARQLGLPSMRILNIGGGFTAGERFAEAAGFIRNALRSHFTDQVTVIAEPGRFFAETCFTLATNIIGKRVRGELREYWISDGI... | 195 |
A0A3B6C7J9 | 2.4.1.18 | ACT_SITE 484; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 539; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MASPAFAVSAAGLARPSTPRSGGAERRGRGVELQSPSLLFGRNKGTRSPRAVSVGGSGWRVVMRAGGPSGEVMIPDGGSGGTPPSIDGPVQFDSDDLKVAFIDDEPSLQDEGEDSIWSSETNQVTEEIDVEGTNIMDKESSTGEKLRIVPPPGNGQQIYEIDPTLRDFKYHLEYRYSLYRRIRSDIDEHEGGMDVFSRGYEKFGFMRSAEGITYREWAPGADSAALVGDFNNWDPNADHMSKNDLGVWEIFLPNNADGSPPIPHGSRVKVRMDTPSGIKDSIPAWIKYSVQTPGDIPYNGIYYDPPEEEKYVFKHPQPKR... | 73 |
A0A2K1KPB8 | 1.1.1.37 | ACT_SITE 208; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MAARFAAAGLLKRALSSAPQQQVRCMSSQTPKRKVAVLGAAGGIGQPLGLLMKLNPLVTDLSLYDIAGTPGVASDLSHINTGANVEGFAGEQELAKALKGCDLVIIPAGVPRKPGMTRDDLFNINAGIVKSLASAIAEHCPGALVNMISNPVNSTVPIAAEIFKQKGTYDPKRLFGVTTLDVVRARTFLAHKKGLNVKDVDVPVVGGHAGITILPLFSQATPKVDLSDEELEALTKRTQDGGTEVVQAKAGKGSATLSMAYAGALFAESCLKGLNGAPDIVECSYVASTVVPGLPYFSSKVRLGPNGIEEILGLGSLSDY... | 5 |
A0A0A0KPG9 | 3.1.1.11 | ACT_SITE 358; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAQKLHFSIILFSMFILSSSSLPFSTKTNNKAIELWCSRTPYPDVCKHFFNNGEFDPRNLLDIKKAALKIAMERAMKTETLTKALGQKCRNKKERAAWADCLELYQTTILHLNKTFSDKNCSNFDIQTWLSSALTNLHTCRAGFVDLGIKDYGVVFPFLENNNITKLISNSLAMNNCSESDEGNTSDEGFPKWLHGGDRRLLQAAEPKADLVVAQDGSGNYKTVQAAVDAAGKRKGSGRFVIRVKKGVYKENVVIKVKNLMLVGDGLKYTIITGSRSVGGGSTTFNSATVAVTGERFIARGITFRNTAGPQNHQAVALRS... | 125 |
Q83CW4 | 3.2.2.27 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148" | MTTMAETQTWQTVLGEEKQEPYFQEILDFVKKERKAGKIIYPPQKDIFNALKLTPYEAIKVVILGQDPYHGPNQAHGLAFSVRPGVPAPPSLQNIFKELHADLGVSIPSHGFLEKWAKQGVLLLNAALTVEAGKPQSHANIGWHRFTDKVIESLNDHPEGIVFLLWGSYAQKKSQLITNLRHRILKAPHPSPLSAARGFLGCRHFSKANQLLHEMGRGEIDWALDEKVS | 173 |
H2LW37 | 2.7.11.1 | ACT_SITE 312; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 329; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MEEVTCVPGQFDDAEVDRDQSEPSLLPSLINDVAAQRVDSDEEEDEVDDDYDDEDDEEDWAYHSAANLTSRLNRSGLNCQANRQNPSNKMISSSTPSDKALRKYEHKINLDKLNYADSVINKVTAMQRQKEADTYRVKDKSDRATVEQVLDPRTRMILFKMLSRGIISEINGCISTGKEANVYHAITASGESRAIKIYKTSILLFKDRDKYVSGEFRFRHGYCKGNPRKMVRTWAEKEMRNLIRLQMAGIPSPEPLLLRSHVLLMGFIGKDNMPAPLLKNAALSESKARELYLQVVQNVRKMFQDARLVHADLSEFNMLY... | 99 |
Q8P8U8 | 1.1.1.49 | ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLAQALPIATAAQIDALLQRIDYRSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDEDRVFRLDHYLGKAAVQNLVALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAMEPPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH... | 6 |
P38991 | 2.7.11.1 | ACT_SITE 227; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQRNSLVNIKLNANSPSKKTTTRPNTSRINKPWRISHSPQQRNPNSKIPSPVREKLNRLPVNNKKFLDMESSKIPSPIRKATSSKMIHENKKLPKFKSLSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKM... | 99 |
A0A3Q7F950 | 5.3.1.8 | ACT_SITE 311; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEMEEGFKGLLRLIGSVKNYDWGRTAKESCVGRLYRLNSRTKIDEKQPYAEFWMGTHDSGPSYIVVERGGRIQNGHANGGGIRDKCSLKDWIQKNPSVLGETVLAKWGTQLPFLFKVLSIEKALSIQAHPDKDLAILLHKEQPLVYKDDNHKPEMALALTKFEALCGFISLEELKVIVQTVPEIVEVVGNALAELVLDLSEDDEEEKGKLVLRKLFTEIMSASKDVITEVLAKLISRLNIKNKVRVLTDKEQLVLGLEKQYPSDVGVLAAFLFNYVKLNPGEALYLGANEPHAYVYGECVECMATSDNVVRAGLTPKHRD... | 214 |
D8RPM5 | 1.1.1.100 | ACT_SITE 220; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MASASLISGFATTTPAAAPALQSRQHLRFGRNLQLCSSLSVRSSCSSSAIRAQVATATEPSHEPTKLVEAPVSVVTGASRGIGKAIALALGAAGGKVLVNYARSSKEAEDVASQIEELGGSALVYGGDVSKEEDVEALFKAVIDKWGTIDILVNNAGITRDTLLMRMKKSQWDEVINLNLSGVFLCTQAATKVMMKKKKGRIINISSVVGVTGNAGQANYSAAKAGVIGFTKTVAREYAGRSITANAIAPGFIASDMTAKLGDEIEKKILQTIPLGRYGQPEEVAGLVKFLALDPAAAYITGQVFNIDGGMVM | 2 |
A0A8V0XQG0 | 2.7.10.1 | ACT_SITE 1067; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MLMPRRYLRRRGRSPAPSRARRSSVGAFASLPSPRKEPPAASGRTMPRQLLSGTVLLGAAFLLAGSTSGSKLKVPVLSVNGRQHVVQAGQTLNLTCRGEMLHSWSLPEALSKDSKRLNVTKYACGRNGTQFCSTLTLSRTQANDTGRYSCRYPTSPVKKKRESIVYVFINDTSNPFVEMHSDIPKIIHMTVGKEMIIPCRVTAPNIAVTLKKIPRETLIPDGKTIIWDNMRGFRIPEATYRFIGLLSCETTIGGHKYSTKYLTHRETNTIFDIKLSTPRLVKLLKGDSLAINCTVKAAWNTRVQMTWTYPGEAMKRGSVT... | 97 |
Q54GY6 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVGGLPNSSLWNIEYDDLVFKDIIGKGNFGCVYRGNYLGVEVAIKQIPSFDDPDYCKYTEREVKALRYIRHPFVVHFFGACKHESGFYLITEFIEGLDLRRYLKSVPKPPKWLSRVNIALGVAKTFLFLHSKNLLHRDLKSKNILLDISRNQIKLCDFGFARVGSQYSNGSDSSSSEDESDSECVNGAAGGGGDDVYKNNGNGKPANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVFSFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVNIPSPNDCPIQFYDLALKCCSYKHTNRPMFSTIVTILESIKLQL... | 99 |
H9G7D1 | 3.1.1.4 | ACT_SITE 71; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 116; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | KGEATLRCDTFCLVALPGPVLVTGVASQLNEMIQLSTVTFSLANFTNYGCHCGPGTQGFPVDDIDRCCHGHDCCYNKAEMFGCTPHLHTYRFYAQRDKIKCVKSRDRCEKLICECDRKAAKCFGKHIFTYNPQLKNHPMANCQAQRPFC | 130 |
Q6DFJ1 | 2.4.1.18 | ACT_SITE 344; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 399; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MATEGKEVQVEVPELDVLLEQDPYLKLYEKDFRRRYGLYTQLLKSIEGNEGGLEKFSRSYQSFGIHVLANGGICCKEWAPGAEAVFLTGDFNGWNPFSHPYKKMDYGKWELHIPPREDNSVIIPHGSKLKVVITSKSGETLYRISPWAKYVVREDKKAVYDWVHWEPLQPYKRKYATPKKLKSVRIYESHVGIASPEGRIASYKNFTYNVLPKIKDLGYNCIQMMAVMEHAYYASFGYQVTSFFAASSRYGTPDELKELIDVAHSMGIQVLLDVVHSHASKNSEDGLNKFDGTESCFFHDGARGNHDLWDSRLFDYSNWE... | 73 |
Q817M1 | 1.3.5.1 | ACT_SITE 284; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPPVKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFLRAVVDDEGVCRGIVAQDLQTMEIRSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL... | 28 |
Q6ED60 | 3.1.3.48 | ACT_SITE 837; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1"; ACT_SITE 1153; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1" | MTMYLWLKLLAFGFAFLDTEVFVAGENPTSPTTGPTATKKSSVPLSGDPLPTHTTAFSPASISERENGFLETTPSLSPASTSTQVSLDSLDNASAFKTTGVPSEQPPHLPTQADSQTPSAGTDTQALSGLAAHATLSPAPGSNDASDVPGERSTASPFPTDPVFPLGTTPIPARNSSAALPARTANTTITASSPDSHALETITLSPSGSTAHSTKIVATTPAKPSCDEKYANITKLFTAKLNVNEVVKCAEFDCTNNMLHNLKECEIRTVTISDNSCTAPNKTLILDVPPEVDKFHLKDHTSPEKANTTINLKWENTENF... | 149 |
Q05609 | 2.7.11.1 | ACT_SITE 676; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEMPGRRSNYTLLSQFSDDQVSVSVTGAPPPHYDSLSSENRSNHNSGNTGKAKAERGGFDWDPSGGGGGDHRLNNQPNRVGNNMYASSLGLQRQSSGSSFGESSLSGDYYMPTLSAAANEIESVGFPQDDGFRLGFGGGGGDLRIQMAADSAGGSSSGKSWAQQTEESYQLQLALALRLSSEATCADDPNFLDPVPDESALRTSPSSAETVSHRFWVNGCLSYYDKVPDGFYMMNGLDPYIWTLCIDLHESGRIPSIESLRAVDSGVDSSLEAIIVDRRSDPAFKELHNRVHDISCSCITTKEVVDQLAKLICNRMGGPV... | 99 |
Q869T7 | 2.7.11.1 | ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSNLKLSNNNNGNQKESSSFFQKVMKSPSTQNLLNSFSSNNSNNNLSNSGSNEVKDTTTNSPSQLPPNYTPPPPPHQIRNSSSIEGGEFSLLNNENSDNNNNNNNNNNNNNNNNNNNNNNNNNNNEQLARTESSVSIISSSSSGSNSGQPNLQRHSSNISTDDSNTTTETYSMSPNQTLNSNIDSSEQQHQDLSSSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTHESRKLTRKIAQFISSPKLLQSSISQLPSTPTQQNVEIQTTNGGSSETSPNGLISPRPSNDQPLKEKKKKKFLKTPEIFKHHHHHKESSLSSS... | 99 |
D8S2R2 | 1.11.1.24 | ACT_SITE 69; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MVELFLFFQTIDFNLHKYQIDRPLVGSMAPNFEAEAVHHQEFIKVKLSNYIGKKFVVLFFYPLNFTFVCPTELTAFSDRYGEFQKLDTEVLAVSSDSVFSHLAWIQTDRKSGGLGELNYPVVSDLTKAITKAYRVLLPDQGISLRGLFIIDKEGIVQHATINNLAVGRNVDEALRLVQAVQYVKVHPDELCPAGWQPGEHGIKPDPKHFAAV | 12 |
O14299 | 2.7.11.25 | ACT_SITE 1161; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGLEHTFYPAEDRFEPLLEHSEPVNFVPKENAKSYVRQGFASPHQSLMDNLVDSTESTKRSENFVSHIPLTPSHSGQSEKLMSTRTSHSPYISPTMSYTNHSPANLTRNSSFNHQHYSTTLRSPPSMRGRGIDVNSSHYPHISRPRTSSDSQKMYTRAPVDYYYIQENPYFNNIDQDSISDKSLPSTNQSLHHSEEDTESDNDFSESIHPEFDIDVFYKVSNILYDESDLQDPEKRERLEWHSMLSSVLKGDVMQTEKRRLRLTEPDGHSGTYISEVWLGLQAWLHGRLNADQAEVIRKSREGVEPVLREVIDFQIQDEE... | 105 |
F6PPJ1 | 2.7.11.13 | ACT_SITE 364; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000554-1" | RDIVKMSIDAGSHQILAKVYYSGHAFSLHLEHTIQMEELFTMVRLNCNFPDAQVFTLKWMDDEGDPCTISSQLELSEALRLYRHNNETVLLFHIFLGIPVEPGLLCPGEHKLYRHGARRWYKLKRILRQIKKPKHPRIPIESGPILDSGDSQDSKQFHPRFCYNECNCILTMSPQIFKQNLKQLLLHIPPSFCLSNYRSYLVVTPYVLCKQTPIYTKYKQTSASSDQASPNAPGFGLKDFEMLKVIGRGSYAKVLLVKLKSTDKMYAMKVIKKELVTDEEDIDWVQTEKHVFETASNYPFLVGLHSCFQTPERLFFVIEY... | 100 |
A7REY1 | 1.1.1.205 | ACT_SITE 341; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 439; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MASSPSKSAPKADYLISGPTSYVPEDGLTANALFGGGQGLTYDDFLILPGFIDFSADVVELNSALTREITLKTPFVSSPMDTVTESAMAVAMALHGGIGIIHHNCSIEFQADEVKKVKKYKQGFINDPLVLSPRHTVKDVIEIKKKNGFSGIPLTENGCMGGVLAGIITSRDIDFLGPEQIDEPLSEFMTPLNDLVVAKDDCTLQEANRILQQSKKGKLPIVNENGELVSLIAYSDLRKNREFPLASKDSKKQLLVGAAIGTRAEDKLRVEALIHAGVDVIILDSSQGNSAYQIDMIKNIKELCPRLQVVAGNVVTACQA... | 3 |
A0A1B6Q5Z8 | 3.1.1.11 | ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGMRRARFLACIAMAAIVLLAPPSTCGVAGHSRGLRPGRSAGAGGAGDPPPLFPVNATRAEMIERQFMEWVRYMGGLRHSTFQHALARAFPSYSLVVDKNPAFGDFTTIQAAIDSLPVINLVRVVIRVNAGTYTEKVSISAMRAFITLEGAGADSTIVQWGDTADSPTGPKGRPLGTFNSATFAVNAQYFLARNITFKNTSPVPKPGATGKQAVALRVSADNAAFVGCKFLGAQDTLYDHSGRHYYKECYIEGSVDFIFGNALSLYEDCHVHAIARDYGALTAQNRQSMLEDTGFSFVNCRVTGSGALYLGRAWGTFSRV... | 125 |
B8BUV0 | 3.5.1.2 | ACT_SITE 87; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 214; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 216; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MTTPSITIGVLALQGAFEEHQRCIESISPSITTLQIRTPSQLSQIDGIIFPGGESTAMGLIGDATTGLWGALRTFVRESGKPTWGTCAGMILLAERCVGTSAVITKGQSLIGGVDILVCRNYFGSQISSFEMDTPAPPRPEVCVDGMTSCSSAEEGENASFPGVFIRAPAILTAGAGVEVLGKVVAAPWASDETNAREVICAVKKGNILCTAFHPEIADDLRWHEYFVGMVLASKQSA | 181 |
F6WYP6 | 2.7.10.1 | ACT_SITE 749; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MERRWPLGLGLLLLLCATLTPGARAKEVTLMDTSTAQGELGWLLDPPEDGWSEVQQMLNGTPLYMYQDCPVQEGGDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGARPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVEHCSLGLLTRRGLYLAFHNPGACVALVSVRVFYQRCPEAVHGLAQFPDTLPRLGGLVEVAGTCLPHAQASPGPSGAARMHCSPDGEWLVPVGRCHCEPGYEEGGDGEGCLACPGGSYRADMGAPHCLQCPQHSTAETEGATICTCEDGHYRA... | 97 |
G1KJ54 | 2.7.10.1 | ACT_SITE 1020; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MYTNGYEHLVYLHTVLIRLFFKFCFLGSSLGSRWKGPKLNITGTQHVIQEGDSLNIMCSGEVVHSWSLPESLTKDSKRVDIITSTCGRNGKQFCSSLTLNRAQPGDTGYYRCKYPSSSALRKKTVSKIYVFINGTHNPFVKMHKDVPETILMMDGQELIIPCRVTAPDIRVKLKMNQGESIMPDGKTIIWDSTKGFVIPNATYKFIGLLACETNVDGHDYSTNYLTFRQANEILSVQLNASRPVKLLKGHNLVLNCTITAAWNTRVQITWKYPGEASKRGTIARSIVQRSDEPNLFYSILVIDKVRDIDKGQYTCNVKSG... | 97 |
A0A9R0I6T9 | 5.1.3.3 | ACT_SITE 173; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 306; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MADQPKKAEIFDLDNGSMHVKISNYGCTITSLSVPDKDGKFADVVLGFDSVDPYLQGAGSYYGCIVGRVANRIKEGKFTLNGVEYSLPVNNPPNSLHGGKNGFDKKIWDVVEYKKNDTSPSITFKYHSRDGEEGYPGDLSVTATYTLTSKTTMKLDMEAIALNKATPVNLAQHTYWNLSGHNSGSVLNHHIQIWANHYTPVDKNTIPTGEITTVKNTPFDFTSEKRIGQDIDKVIGLGYDHNYVLDSGDEKMGLKHAAKVREPKSKRVLDVWTNAPGVQFYTGNYVNGVTGKGGAVYDKHGGLCLETQGFPNAINQPNFP... | 211 |
Q9X2I6 | 4.1.1.17 | ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MMEYWIRRALEVVKTPFLLFDLSVVEKKYLEMKAALKKADIYYAVKANSHPRIISLLARLGSNFDVASKGEIEKLLALGVDGKRMSFGNTIKREEDIAFAYKNGIRLFAVDSEMEVEKVAINAPGSFVFVRVETDGADADWPLSRKFGTNPEHALQLLSYASKMKLIPAGLSFHVGSQNLNPESWKKAIEIAGRVFKKAMRSGLNLFLLNVGGGFPVQHTKPIPSMEEIGKAIEEAIDENLWFVHNLKVIAEPGRYMVGEAGWLVTKVLLKSERSGEKWVYIDAGVFHGLAETIQNFEYEIRVLGKEREELEEYHLAGPT... | 195 |
A0A9J7LD89 | 3.1.3.1 | ACT_SITE 134; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MAGTTAVLVAYSLLAVLVTVKSGSVDEHAHRARSITRENGGAPEREKNPQFWNNMAKNSIQDALRIQRSHNMKIAKNVVMFLGDGMGVVTVTSARILKGQNAGNPGEETVLTMDTLPHVALSKTYNIDAQTPDSAATATAYLCGVKAAYATVGVDGRAWNKDCSSSKGAEVQSILALAESAGKSTGVVTTARMTHATPAATYAHSASREWEADRDLSPEAVQNDCKDIATQLVDDNPGIEVLLGGGRRNFHTGTDPEYPDDPGSNGVRSDGRNLVQDWLVGKTSARYVWNGTDFRTVNPQTTDYLLGLFEPSHMKYMTDR... | 141 |
F4J270 | 3.2.1.39 | ACT_SITE 127; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 264; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MKMCNGSSFLASLPLLLLLLSFILASFFDTAVGQIGVCYGRNGNNLRPASEVVALYQQRNIRRMRLYDPNQETLNALRGSNIELVLDVPNPDLQRLASSQAEADTWVRNNVRNYANVTFRYISVGNEVQPSDQAASFVLPAMQNIERAVSSLGIKVSTAIDTRGISGFPPSSGTFTPEFRSFIAPVISFLSSKQSPLLVNNYPYFSYTGNMRDIRLDYTLFTAPSTVVNDGQNQYRNLFHAILDTVYASLEKAGGGSLEIVVSESGWPTAGGAATGVDNARTYVNNLIQTVKNGSPRRPGRATETYIFAMFDENSKQGPE... | 167 |
H2XKZ9 | 4.1.1.17 | ACT_SITE 321; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | ESDSSFYLGDLGQIVRNLQMWRKHMPQIRPYYAMKCNPSQPVIQLLASLGVGFDCASGFEIESALKCGVQPDDILFAVPCKMSSHIKYACQTGVRTMTFDNADELHKIKRIHPTGKLLLRLRVEYCGIGIKMDDKFGASMSEAEKLILLCKELKLNLAGICFHPGSGSNSFDPIDRSLQQCRELYDFANLNGIDLKIIDIGGGLVCTESFIKVSFQITTAVNKLFPPETGVKVIAEPGTFLVENAFSFVTNVHGKALVGVYVGINISKSLSTDTAKYYIGAGVFTAFNLKFFEEFKRIPENLSREAEKGKYYRTSVYGPT... | 195 |
B9RA28 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIMIVKAALLILALGLFLGNLAGLCNGALQVGFYSGKCGFADVEAIVAGVVTPQFFKDPTIVAALLRLQFHDCFVNGCDASLLLDGRSSEKTAPPNLSVRGYDIIDQAKTAVERACPGVVSCADLIAIATRDVVFLSGGGRYNVQTGRRDGLISAGQNVSILGPKASVPEAVAAFAEIGLNTTDMVLLLGAHSVGVTHCSLIKDRLYDFEGSGNPDPLMDPFLVNLLRFRCPQFPAIDNTVNLDQNPFSPFFMDVSYYQNIMMHRGILQIDQELGMDPLTMPIVRNLAGEFDFPTRFGAAMVKLGTIGVLTDKQGEIRRS... | 14 |
M5WH45 | 2.3.1.286 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSLGYAEKLSYIEDVGQVGMTEHFDPPPVLQEKIERLAMLVQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKALPEASLPFHRAMPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLAELHGNSFLETCPSCGVEYLRDFEVETIGLKETSRRCSDKKCGARLKDTVLDWEDALPSKEMNLAEKHCRIADVVLCLGTSLQITPACNLPLKSLRGGGKIVIVNLQKTPKDKKANLLIHGLVDKVISGVMDFLNLQIPPFVRIDFFQIILTQALSSDKKNVNWNLRVASVHGQKAPLPFIKSIEISFLE... | 58 |
A0A2R6WR46 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATMGRLVVVVVVVVVAALSLATSVAGARVELQQFAPSVNLGANLSSLEQQLPLEAGLVWGYYSKSCPRAESIVTQKVSEAIRNDPGIAPGLLRIFFHDCFVKGCDASILLRNSRGSELNDVPNRTIRQSALNLIDQIKAALEQACKGVVSCADIVVLAGRDSVKLAGGPSFNVPLGRLDSFTIFPTNALPTPFASFNDQLNGFKAVGLNTQDLVALASGGHTIGISQCASFQGRIFPNLDPKLNKDFGNALRQMCGNSGNTVGIDFFTPNKFDNQIYKNFLTGGALLLSDQNMDSDSTAWNLVKTWANNQGAFFNQFLS... | 14 |
P9WG33 | 2.2.1.2 | ACT_SITE 143; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250" | MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGVTTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDGVDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGISVNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIGSRQALELRGQAGVANARLAYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYSDTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGT... | 52 |
A0A9R0IAD9 | 3.2.1.143 | ACT_SITE 301; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 319; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 320; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MCTLIYVQPSTIRALKFLPQKSKPSAPIIIKMVNRADFKSVLPFLPPLKSLTSGSLAWPNPQVTAALELVSQGPSRSRVDSGERLYAAISRVRGSLPLSAKDRLAKSTDKGFAKLFDELLPKEESRRWLENVAPKMADLVLRLPALLESHYRDCDNVVPGVSTGLRLLEPQQSGIVFLSQELIAALLSCSFFCLFPTVNRKAKRMRAINMDQIFSSLHDSYHTKQENKMKCITHYFERICSSTPSNFVSFERKVLSLEQNPSVVPLPSPEFWANSVTPLCKFKVFPTGKIEHHPPGASEVDFADEFIGGLVLTKGCVQEE... | 159 |
D8T5E8 | 2.1.1.37 | ACT_SITE 562; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MAKVGTGSARSRKKSGPRRASATSSGTVKEEDVAAKEDPCPQRPSGDCIVVLDSSEEDQLSPSAVVREEDIGKKVDKKAGKSVQRKDPGPNPKPKPKPRKSFGPKKQPLPPPPSPDDDDFAQEPILVESDDDDEEDSPSAALVACPRKGHKLAVKAHFVGKPIPAARAKRQWPNRYDKSAGAGSQKCVEHYEEAVVDGKHYKVGDCVALELQGDDAEYLGKVLEFFKTANQENWFRVQWFFRFSDTVCLRLCGYPDCKCSLQAIGDLDDVHLDNKRVFLSDDEDDNMIECIIKKVKVSYAPVMDAFSKKKIKQSCDYYFD... | 47 |
Q8L6Y1 | 3.4.19.12 | ACT_SITE 317; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 758; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MELLRSNLSRVQIPEPTHRIYKHECCISFDTPRSEGGLFVDMNSFLAFGKDYVSWNYEKTGNPVYLHIKQTRKSIPEDRPLKKPTLLAIGVDGGFDNNEPEYEESYSIVILPDFVSLPFPSVELPEKVRIAVDTVVNAVGAERKEQVAAWTAEKKLISEHALTLQQIKSGIVIPPSGWKCSKCDKTENLWLNLTDGMILCGRKNWDGTGGNNHAVEHYKETAYPLAVKLGTITADLEAADVYSYPEDDSVLDPLLAEHLAHFGIDFSSMQKTEMTTAERELDQNTNFDWNRIQESGKELVPVFGPGYTGLVNLGNSCYLA... | 175 |
Q9KZL9 | 5.3.1.8 | ACT_SITE 270; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MDRLDNTVRPYAWGSTTAIPTLLGTEPTGEPQAEMWMGAHPGAPSRTGRGTLAEVVDADPEKELGAASVARFGPRLPFLLKLLAAGAPLSLQVHPDLAQARAGYEDEERRGVPLDAPHRNYKDANHKPELVCALTDFDGLCGFRAPAETADLLDGLGVASLKPYVDLLRAHPEDAALREVLTAILTADPEEMSHTVTETAAACDRLGGAYRPYADIAHHYPGDPGVLAAMLLNHVRLQPGEALYLGAGIPHAYLNGLGVEIMANSDNVLRCGLTPKHVDVPELLRIVRFEAGDPGILRPEASPDGEEVYDTPIDEFRLSR... | 214 |
C5YZJ2 | 1.11.1.7 | ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSAGTRADEVVVQVRQLVVVVAVAVMATSCFSSSEAQLQVGYYNATCPAAESLIETIVHAAVRKDAGNGPGLIRLFFHDCFVRGCDASVLLDDPTGTPGNRTVEKTSQPNFPSLRGFSVINRAKRVVERRCPGTVSCADIVAFAARDAARIMGGIRFAMPSGRLDGRVSNASEATANLPPASFNLTQLLARFASKNLTADDLVTLSGAHSIGRSHCSSFANTRLYPQLDATLNVTLAARLRAKCPAAPGGKDRVVDLDFRTPLQLDNQYYSNVATHEVVFGSDQALGDRNDTAALVALYAANRKIWSQKFAAAMVKMGSI... | 14 |
A0A9R0J4V2 | 3.1.1.11 | ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPYPKMSKILPFLILLLLSLSLNEALYNEKTVYNQIPAKILQNMISQACANVEDEINCLSNVESRLPNGPRNASSVLKAALETSLNEVQLALRKVSDFSSLSSSTAREQIAVEDCKELLDYSVTELAWSLSEMREIRVRGSVHDRGGDLQAWLSAAVSNQDTCLEGFEGTNQHVRNNIKGSLTQVTQLISNVLTLYTQLHALPFRPPRHNHYHNNNDTNKNNDQDYFPKWMTEGDKELVVSSSTSKGIHLDAVVSLDGTGKYRSINEAIDDAPNHSNRRHVIYVKKGVYNENVDMKKKKTNIMLMGDGIGATVISSNRNF... | 125 |
Q89ZY4 | 5.4.99.12 | ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MQRYFIYLAYDGTNYHGWQIQPNGSSVQECLMKALSTFLRRDVEVIGAGRTDAGVHASLMVAHFDHEDVLDTVTVADKLNRLLPPDISVYRVRQVKPDAHARFDATARTYKYYVTTAKYPFNRQYRYRVYGSLDYERMNEAARTLFEYIDFTSFSKLHTDVKTNICHISHAEWTKMEGEDTTWVFTIRADRFLRNMVRAIVGTLLEVGRGKLTVEGFRKVIEQQDRCKAGTSAPGNALFLVNVEYPEDIFSEETKKSVLSTLLPEGGEC | 217 |
P19669 | 2.2.1.2 | ACT_SITE 84; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000250" | MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRLREITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLGIKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQIIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK | 52 |
W5N013 | 3.1.1.3 | ACT_SITE 173; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 196; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 294; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MIVRWTILAIYIATATDLGAEVCYDRLGCFGNDKPWAGTVERDISQLPWSPERINTRFLLFTRQNSNSFQDITAINPSTISASNFRSNRKTRFIIHGFIDKGEEGWVTDMCLEMLQVEDVNCICVDWKGGSRCPYTQAANNIRVVGAEVAYFGEVLQTQINYHPANIHIIGHSLGAHAAGEAGKRKPGISRITGLDPAEPYFQNTPIEVRLDPSDAAFVDVIHTDAAPMVPNLGFGMIQAVGHVDFYPNGGEEMPGCNKNAVSQILDFGFGLVSQIVDIDGIWEGTRNFVACNHLRAYKYYTDSIKQRDGFIGYPCSGYG... | 128 |
E1JHB8 | 2.7.10.1 | ACT_SITE 1094; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MAMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIGNGHIDKDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRN... | 97 |
M3WV69 | 2.7.11.25 | ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MEPLKNLFLKSPLGSWNGSGSGGGGGGGGGGWPEGSPKTAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMDHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGE... | 105 |
Q551H4 | 2.7.11.1 | ACT_SITE 195; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159" | MSDDKYHHDKHHDKHHIDSKQSTAAALSSSSTLASSSSMTTTTTTTSTTTTAASPITPKPRKNYPNSADQYELKETIGKGGSGLVQRAICLPFQENVAIKIIDLEHCKNVSLEEIRKEIQAMSLCHHPNVVAYHTSFVYNESLWVIMDFLSAGSCSDIMRFSFPQGFEEHVIATILKEALKAICYFHKTGRIHRDIKSGNILIDSNGNIQLSDFGVSATLIDTGETSRNTFVGTPCWMAPEIMEQVNYDYAVDIWSFGITALELARGKAPFAEYPPMKVLLLTLQNPPPSLEGDGESKWSHSFKDLVEKCLQKDPSKRPL... | 99 |
A0A2C9UXM7 | 3.2.1.1 | ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MNFLSPLCVLSFLLFVFPSFISSQLLFQGFNWESCNKAEGWYNSLKNMIPDLANAGVTHVWLPPPSQSAAPQGYLPGRLYDLNASKYGTQDELVSLIDSFHQKGIKSLADIVINHRTAEKKDDRGIYCIFEGGTPDGTLDWGPSFICRDDTAYSDGQGNPDTGEDFKGAPDIDHLNPRVQIELSDWMNWLKTEIGFVGFRFDFVKGYAPSITKLYMEETLPEFAVGEKWDSLAYGQDGKPDPNQDGHRVALEDWIQAAGGAVTAFDFTTKGILQAAVQGELWRLKDSNGKPSGLIGLFPQNAVTFIDNHDTGSTQNLWPF... | 157 |
A0A061G1F5 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATLALNKLFLPIVFLVLIIEVSQSKAALDARYYDQTCPEAEKIILDTVRNASMHDPKVPARILRMFFHDCFVRGCDASVLLDLTPQNKAEKDGPPNISLQAFYVIDDAKAKLERACPQTVSCADIITIAARDVVAMEGKMEESPVQPKQLTYQRQLSTFRNSIQSFAKRGLGVKDLVALSGGHTLGFSHCSSFQARLHNFSSVHDIDPSLNSEFAETLRKKCPKPNKDRNAGQFLDSTATRWIVESFAKDQTLFFKEFAASMVKLGNVRVIENGEVRLKCRVVIKMRINMLASIILLEEVMPHPQT | 14 |
A0A0A0LZD6 | 1.11.1.7 | ACT_SITE 40; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGFILFHVQKQNQSIVRNTVESYMNTDPTIAAGLLRLHFHDCFVQGCDGSVLISGNLAERNALPNLGLRGFEVIEDAKSELEAECPGIVSCADILALAARDAVDLSKGPSWSVPTGRRDGRVSSKSEAQNLPSPLESIAVHKKKFAEKGLDEQDLLTLLELKELCPNDGDATKRVALDKDSQFKFDLSFFNNIKDGNGVLESDQRLWNDDSTRSIIQKYISPLRGLLGLRFDYNFRKSMIKMSSIEVKTGMQVEIRRKCSRFN | 14 |
H9G4Q2 | 2.7.10.1 | ACT_SITE 802; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MRDSLNIPLVHIFTLAAFSLAERLPKAPMIITPLETVDALVEEEATFECVVESFPQAEITWTRNNIPIRLFDTRYSIRENGQLLKILSVEDSDDGVYCCTANNGVGVTAENCGALQVKMKPKITRPPSNVKIIEGLKAVFPCTTMGNPKPSVSWIKGENVVKENTRIAILESGSLRIHNVQREDGGHYRCVAKNSLGTAYSKPVILEVEVFARILKAPESYNISFGSVVTLQCAATGIPTPTVAWLENGKAVSAGSIVETVKDRVIDSRLQVYVTRPGLFTCIATNKHSETYGTAKAAATINVSGIRLYKGDAGYCSTYR... | 97 |
Q9M2S4 | 2.7.11.1 | ACT_SITE 472; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSQTFAVILLLLIFLTHLVSSLIQDFSFIGFKKASPNLTLNGVAEIAPTGAIRLTTETQRVIGHAFYSLPIRFKPIGVNRALSFSTSFAIAMVPEFVTLGGHGLAFAITPTPDLRGSLPSQYLGLLNSSRVNFSSHFFAVEFDTVRDLEFEDINDNHVGIDINSMESSISTPAGYFLANSTKKELFLDGGRVIQAWIDYDSNKKRLDVKLSPFSEKPKLSLLSYDVDLSSVLGDEMYVGFSASTGLLASSHYILGWNFNMSGEAFSLSLPSLPRIPSSIKKRKKKRQSLILGVSLLCSLLIFAVLVAASLFVVRKVKDED... | 99 |
O14132 | 2.7.11.1 | ACT_SITE 161; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKKYLWGTPTTNTVFTGKQPKYTKEVRKCISIDEVYNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSENENIVNIFDLYIDQFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILISSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGCMAFEIATLQPIFPGNDDFDQLYKMCEILGSPDEQSQNTGDKGGGIWDRAELLANKLGISLPKMAPLDFGDLFSPPWNLAFASMLSQLLKWD... | 99 |
A0A1U8A5G1 | 3.1.1.11 | ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLPKKVLILNTFINLPFLPPFAQKLPKLLAIFMASTLLRTFLLLSTIFIVRPWAVNSSSFSSATDTTLDAHLASIRSFCKSTPYPDACFDSLKPSISINIKPNIIGYALQSLQTAIFEADKLLDLFLNIGSLGVVEKQKGAIQDCKELHQITMSSLQRSLSRIRSGDARKLSDARAFLSASLTNKNTCLEGLDSATGPLKSVIVQSITSVYRHISNSLSMLPKQELRKVTEGSNRRLMGFPAWVSRKDRRILQSFDGDYNPNDVLTVAKDGSGNFTTITDAVNFAPNTSYDRTIIYIRAGIYQENLDIPSYKTNIVLLGD... | 125 |
Q59WI0 | 2.7.11.1 | ACT_SITE 249; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 266; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MSSEEILQGVEDIHLNTSSDSDSEYELEEETTTKSLPSSSRTITEKEDIVTKYADKIKTDPIKKGPKITKDRANRATVEQVLDPRTLRFLAKIINKGIISRINGCISTGKEANVYHGTSDDPDNDREYAVKIYKTSILVFKDRERYVDGEFRFRNTKNQSNPRKMVKVWAEKEFRNLKRIYQNGIPCPEPIELKSHVLVMEYLTKGDGQPSPKLKDYSFKDVQDIVNYYHKMLFYMRRLYQECRLVHADLSEYNSIVHKDNLYIIDVSQSVEPEHPMALDFLRMDIKNVNDFFSRSKINVYPERLIFRFITSEGHLLGIA... | 99 |
Q5MD89 | 2.7.10.1 | ACT_SITE 1045; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MKRDFTFFCRIWIGIPFFSGLVNGFSMSPPTLDNTKDQLVINANDTLNITCRGQRILDWSWPEESLSKVEFTDRQGQQSPTDTPGYREIRLKECQGVAGKPYCKILILTNAQANDSGYYRCFYKDIKAVIDGTTAASIFVFVRDPEHPFIKRGDNDMETIFITDSETHIEVPCLVSDPDLKVTLFSLVPYPEPVDGSVVTWNNKKGWSIPRHIIQNTSTFIGFYCSISVQNSQHTSSIYVVQVIGLKFYEFKLFPEDSPVELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEISSILSIRN... | 97 |
I1JK63 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVKFTIVVIFLFFMFPIAFADLRVGFYSSSCPRAEQIVGQVVQRRFNRDRSITAALLRMHFHDCFVRGCDASILIDSTRGNQSEKAAGANGTVRGYELIDEIKKALERECPSTVSCADIITLATRDSVVLAGGLKYDVATGRRDGHVSQSSEVNLPGPRSTVSRVLEVFSANGMSLDEMVTLLGAHTVGFTHCSFFRDRLNDPNMDPSLRAGLGRTCNRPNSDPRAFLDQNVSSSMVFDNAFYKQIVLRRGVLFIDQQLALDTLSKGLVTVFAGNNAAFQRSFADAMVKMGNIKVLVGNEGEIRRNCRVFNSAS | 14 |
Q5KF83 | 3.4.19.12 | ACT_SITE 316; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 743; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MSCTHLQPSLHSLKPPSPSQQVHREECTLCFDGQDDPRGVVVCLSCFNGACLSPDRQHAHLHYQRTGHPLGMVIKRSRKEIRKRDSSEPPMKKLAISAPKDEEIWDYHTAFVCLACSSAGQEITAQEPKLEEMKTGIMTALSSAQQSEIKAWEEEILPCEHTLTLQQESVVVPGNVPSQCSSCDLTCNLWLCLTCGLANCGRQQFGGIGGNGHALKHFHETGHMLGVKLGTITPEGTADIYCYACDDAKIDPELATHLSTFGIEVMSQTKTEKSMTELQLEHNLKFDFSMVGDDGKELEPVFGKGLTGLRNLGNSCYMAS... | 175 |
A0A804RDM1 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLMMTWTWTCNAKLLLMTLVFAAALSATVTTSRAQSPPLQYNFYGASCPQAEATVRNVTEGIIANDRTMGAAFMRLFFHDCFVRGCDASILLDPTSSNTQVEKKAIALRGYAAVNTIKAAVEAVCPGVVSCADILAFAARDTAVVSGGFAGFGMPSGRRDGVVSSFIEVLQNIPSPTFKLPDLVSNFAKKGLDVDDLVTLSAAHSFGQAHCSFVNGRLYPTVDPTMNATYAAGLKTVCPPPGSGGGDPVISNNRVTDPNALSNQFYSNLMTGQVLFVSDQQLMNTTYTAAKVANNSADSAAWMTQFQTALLKMGSIQVLT... | 14 |
A0A9R0JSY8 | 1.11.1.7 | ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MFPSVKQSKMAATKGFPLILVLSSLIIGLSQGQSTIPVVPGLSYTFYSSSCPGLDFIIRGHLWQIFQSDLTQAAGLLRLHFHDCFVQGCDGSVLLDGSASGPSEKEAPPNLTLRAQAFKIINDLRALVHQQCGRVVSCADITALAARESVFLAGGPFYWVPLGRRDGLNFATLSDTLANLPPPSFNTGQLLDSLANKKLNATDLVALSGGHTIGISHCTSFTDRLYPTQDPTMAQTFANNLKVTCPTATTNATTNLDIRTPNVFDNKYYIDLMNRQGLFTSDQDLYTDSRTKDIVTSFALNQNLFFQKFIDAMVKMGQLN... | 14 |
A0A8V0X6E7 | 2.7.10.2 | ACT_SITE 738; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MAVWSVQGFLFLSGCRSCVRSVAPAPAPGTHQHQRCSGDLAAHSAPSHQDHSAMGFGPELWCPKGHSELLRLQDSELRLLELMKKWMSQRAKSDREYAGMLHHMFSQLEKQEGLGHLRATDHSSQIGESWWVLASQTETLSQTLRRHAEELAAGPLAKLSILIRDKQQLRKAFSEQWQQLSQEYARTTQQEMEKLKAQYRSLVRDSTQAKRKYQEASKDKEREKAKEKYVRSLWKLYALHNQYVLAVRAAALHHHHHYQRALPTLHESLYSLQQEMVLVLKEILGEYCSISSLVQEDVLAIHQEVAHAVEMIDPATEYSS... | 98 |
Q0TXL9 | 3.4.21.92 | ACT_SITE 121; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 146; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MSNRFGFGAPFPSHQEQRQSPQAFSPIPYVTESMGGGFKTSDIFSRLLQERIITLNGEVEDSMSAVVIAQLLFLEAENPEKPISMYINSPGGSVSAGLAIYDTMNYIRSPVSTTCMGMAASMGSLLLAGGEPGQRYILPHARVMIHQPSGGYRGKASDIADHAKEILRIRDRLNRIYQNHLTKERTLEEIEKYMERDYYMDAEEAVEFGIVDKIMEKRVVPGKDEDSN | 179 |
A0A078FV88 | 2.3.2.26 | ACT_SITE 849; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTLRRSTAADSPISHRSPLAVAGTDNHKRKLDDYAADYSLDLLQKMKRHEVDADRISPASQQKPLTSGENYRSLYTPGECSSSSSPSSSSSLPESWTRSESTRLQLFVRMMSGGKTIVIHADRNDTVEHLHHRIQLKTQIPVTEQRVIYKGKQLQFEHTLSHYSIEHDSSLHLVGRMQSTEYPVACQTVDEIMSTISRMHRGENLYGGRTNINDKLVKFFARIPAESNRSSAKYLKIFSNSSVPAALVMLFVSPLEINKACGKSSIKLFLNSCVALPVHQQNSCLPVVLEFCRLLRGACPDNKLYASCRNTLGSMLDLVC... | 65 |
Q09298 | 2.7.11.1 | ACT_SITE 338; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSMKRFGKAAYRIANELVAKGGRLPIFQRFLPRIFPATYNLGVHVVLKKAPFPRQNALRIARLVTRHGRVFRPFSSVIIERHRFQNQNDWRRKFQPIRKELPRNVDLVERIRQIFGNSLRYNEDLKSTEWPNRIDSYEFGEFLGQGCNAAVYSARLANSDAESSGNTHYGAGFNEVTNILAEIPPVSKVAQKKFPLAIKLMFNFEHDRDGDAHLLKSMGNELAPYPNAAKLLNGQMGTFRPLPAKHPNVVRIQTAFIDSLKVLPDAIERYPDALHTARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGRVIIA... | 99 |
O42130 | 5.6.2.2 | ACT_SITE 806; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01384" | MELLDSPAPLRPLHDNPRLPKADGAQKRLSVERIYQKKTQLEHILLRPDTYIGSVETVTQQMWVFDEDVGLNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVTIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACREYKKLFKQTWTDNMGKAGEMTLKHFDGEDYTCVTFQPDLSKFKMTILDKDIVALMSRRAYDIAGSTKDVKVFLNGKRLPVKGFRSYVDLYLKDKVDETGNALKVIHEEVNSRWEVCLTLSEKGFQQVSFVNSIAT... | 222 |
C5XI24 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKLSAAVLCALVAVQAAALLLATVPSAQAKELEVGYYGKKCKGVENVVKWHVIKAIKANRRTGAALVRLLFHDCFVRGCDGSVLLDASSDNPHPEKEAPVNIGLAAFDVLEEIKAAVEKRCPGVVSCSDILIYAARDAASALSNGHVHFAVPAGRLDGFVSKADEAQAELPDSTHDVQQLIDNFARKNFTVEELVILTGAHSIGQGHCSSFRGRLSEPSSQITPAYRDLLNYKCSQGSNPPVDNNVRDEDYDVVAKFVAGFTSRVRKIPDFLDNSFYHNNLAKIVTFHSDWTLLTHKEALGHVVEYAENGTLWDEDFSES... | 14 |
Q9ZWC8 | 2.7.11.1 | ACT_SITE 987; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKQRWLLVLILCFFTTSLVMGIHGKHLINDDFNETALLLAFKQNSVKSDPNNVLGNWKYESGRGSCSWRGVSCSDDGRIVGLDLRNSGLTGTLNLVNLTALPNLQNLYLQGNYFSSGGDSSGSDCYLQVLDLSSNSISDYSMVDYVFSKCSNLVSVNISNNKLVGKLGFAPSSLQSLTTVDLSYNILSDKIPESFISDFPASLKYLDLTHNNLSGDFSDLSFGICGNLTFFSLSQNNLSGDKFPITLPNCKFLETLNISRNNLAGKIPNGEYWGSFQNLKQLSLAHNRLSGEIPPELSLLCKTLVILDLSGNTFSGELPS... | 99 |
A8XU83 | 4.1.1.50 | ACT_SITE 87; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 101; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIR... | MSATATICSEKNFAVQTHPVKAPDEEYFFEGAEKLLELWFCSTKGITDTSLRSIPRSEIDNMLDVARCKILHSKHNESIDSYVLSESSLFVSDNRVILKTCGTTRLLAALPVLMQLAGTYAGLDQVQSVYYSRKNFLRPDLQPNLHKNFDAEVEYLDSFFEDGHAYCLGSLKQDRWYLYTFHREVEFPANKQPDHTLEILMSDLDEEVLHKFTKDFAVDGKDCFMRAGIDKIIPAGADVHDELFDPCGYSMNAYINDTDQYATIHVTPEKEFSFASFETNQDLVCLYSQTRKVLQCFRPNKILMTVFANDISVKGKDAQQ... | 196 |
Q9HR29 | 5.6.2.2 | ACT_SITE 130; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MSSESPDVPDDVADRVKNVRVDEEMEQSYIDYAMSVIAGRALPDVRDGLKPVHRRILYAMHESGVTSGSGHRKSSNIVGDTMGDYHPHGDSPIYDALVRMAQDFSMRYPLVDGQGNFGSVDGDPAAAMRYTEARMAPIAEELLTDIEKDTVAFQANYDDRLTEPAVLPSSFPNLLVNGSSGIAVGMSTNVPPHNLGEVIDATIHLIDTPDCTVLDLMEYVKGPDFPTAANIVGRADVKQAYQTGRGRVRMRAEYHVESNGRRDSIVITELPYQQNKSTLVERIADDVRDGKLEGITDLRDESDRNGVRIVIDLKQKANTD... | 222 |
Q3ZB95 | 5.3.1.8 | ACT_SITE 294; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MAEVKVFPLCCVVQNYAWGKAGLDSEVARLVLGGDPQAHIEHSKPYAELWMGAHPKGDALIKDNRISQRTLGQWIADFPGCLGSKVKDTFHGQLPFLFKVLSVNTALSIQAHPNRELAARLHAQFPEHYPDNNHKPEMAIALTQFEGLCGFRPMEEILGFLKNVPEFRALVGNEASEELQSADGNPHRTSLALKKCFTRMMNCEKKLFVDQLNMLVKRISEEEAAGKDTSGSNGELLLRLHSQYPGDIGCFSIYFLNRIVLQPGEAMFLGANEPHAYLSGDCVECMACSDNTVRAGLTPKYIDVDTLCEMLNYCPAPVSA... | 214 |
Q86IZ3 | 2.3.2.23 | ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MAARLMKEYKVLQNEEFEDILLYPRDESDLYRWVAIIKGPPDTPYENGKFELDISVPTNYPLQPPTIKFVTKIFHPNIHFKTGEICLDLLKTSWSAIYTLQSVCRSIIALLSLPEADSPLNCDAGNLIRNGDVKGHDSLARMYTRLYGC | 64 |
W1NL91 | 3.1.1.11 | ACT_SITE 426; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGVFQDYGHLTERGRVERQKRNKQKRVIVALTSAFAALALIIIAAFAVVSLNKHPEKAQEHQPVKISTSMKAIKSICSPTDYQEACVSSLSSAIKSNSSLTGPEDLIKAAIKVAKKEVIKAFDHASKLRKNARSQMEKEALSNCKELLSYAMDELDETFSGVSVAGLKDLATVSQDLKNWLSAVLTYQETCLNGLEDSNAKSDMAEAMKMATQLTSNSLAIITEASSVLSILKVPGFSRRLLSKENHFSEGKGGFPSWFPAGERRLLAMQEMTPNVAVAKDGSGDFRTITEALSKLPPAKERNGRYVIYIKAGVYDEQVT... | 125 |
H2MBW3 | 2.7.10.1 | ACT_SITE 826; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MWILSVLVWLATLSCCRAAETPGPPLLRLNSTIMPNQSEMVMLAGSAFSVNCQGNRSVKWSSTGIHWSQREETKTVKSANPRHTGTYTCGYTDQSLEHLNTWFHLYIKDPSNPSTVFVTPRQKIITLMEGKSFLFKCLLTDPSVTNLTLQRMDGRPLPPGMNVTLNPKRGALIQDVQVSFRGQYSCSGWRDRKQFRSSPLQLEIRALPPPPTLSVSQNYFVRLEGEPFEVTCQAVNQNHFVNVTWTHRSVKELKISVSRQHINNQLIIRSTLTVSAVSRTHSGEFLCTAYNERGVTTASVQLLVLDSPSLHLYLYLLAPS... | 97 |
Q54PA0 | 5.3.1.8 | ACT_SITE 314; /evidence="ECO:0000250" | MENNNNNNNNNNNNNNNNNNIVLLKCVSQNYEWGKYGSNSTVAKLLKGYAKECSDIIKETIPYAELWMGDHVSAPSKVEYKNKELKLREYIDTVQKEINEKSSTSSSSSSSIRGEIVEKRFGNDFPFLFKVLSIRTALSIQAHPDSQLAQVLFKKYPNIYKDPYHKPEIAIATTPFEALCSFRPLSEIQSFIDTIPEFKNSLPNNLIKLDDCKEYLKSIVTSLLKADGLLISNNLKELNNRLNEKREEERDDLDRLVLKLYSQYPGDVGVFFAYILNYIVLKPGEALFLGAGEPHAYISGDCVECMAPSDNVVRAGLTPK... | 214 |
Q5NB11 | 3.2.1.14 | ACT_SITE 114; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MAKPTPAPRATPFLLAAVLSIVVVAASGAEARWYGGGGGGGYSPSPSPVSSIVSEQLYASLFLHKDDAACPARGFYTYASFVRAATRFPRFAATGCADARKREVAAFLAQISHETTGGWATAPDGPYAWGLCYKEEINPQSSYCDATDKQWPCYPGKSYHGRGPIQISWNFNYGPAGQALGFDGLRNPEIVANCSDIAFQTALWFWMTPRDTKPSCHQVMVGEYRPGPADVAANRTAGFGLVTNIVNGGLECNRAGDARVNNRIGFYRRYCQVLGVDVGPNLDCEHQQPF | 158 |
I1N774 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKLTTILIFFIFALPFTFANLRVGFYTATCPRAETIVGEVVQRRFSQDKSIVAALLRMHFHDCFVRGCDASILIDPTSTRTSEKIAGPNQTVRGFEIIDEAKAILEQACPLTVSCADIIALATRDAVALAGGIRYSIPTGRKDGLLADPSLVILPAPSLSVQGALQFFTARGLTLEDMVTLLGGHTVGFAHCSVFQERLSSVQGRVDPTMDPELDAKLVQICESNRPSLSDPRVFLDQNSSFLFDNQFYNQMRLRRGVLHLDQQLAFDSLSRDIVEDFAANDGTFQERFANAMIKLGSIGVLDGNEGDVRRNCRAFNIPL | 14 |
A0A804JV12 | 3.1.1.11 | ACT_SITE 358; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATLLANLVILYFNFLLVLKVAANDPISWCNQTPHPKVCSSMLENEIAESISQSDFRDVLLRATTARTVLALRQISSMDMTLLDKPAKAALADCLKLYNDTIIRLQHSMRSSSSIEDSQTWLSAAKANERTCRDGFVELGSTFPLASSSFVTNHLSESLSNMLAVNIATPRDKPPPKNRRLLSDGFPRWVKAADRKLIQTGVTIKPDLVVAKDGSGNYKTISEAVAASVNLRQTTSRFVIYVKAGVYSETVDIALNMVNLMMVGDGKDDTIVTGSKNVVDGTSTFNTATFRVDGEGFIGQDMGFENTAGPEKHQAVALRS... | 125 |
Q5BBL3 | 2.7.11.1 | ACT_SITE 686; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNNDSFSSFKFRRPSSKLHKDPPGYGSRALNSQQSTTSLKRHPSAPVYPRSSAAGSREHLRTRSNAYGSSSSSLDQNSAGASPVLGSSDSGHFHSSHSSRSRPPYSGRFSLNDQSSDELIGAPFDSRGMLSALEEHTAEPDNRSYQPPDPAERYTEKPPNFRSQTTPNPRALRQSASFTTLPPRMEAFPNAAGNDRPTNTKRFSDEATPVRPPGPSRSKKSSFSSFVNSMLGSPRGIKISAPENPVHVTHVGYDNQTGQFTGLPKEWQRLLQESGITQKEQEEHPQTMVDIMRFYEKNARGDDEVWHKFDHAYPQQPTAA... | 99 |
A0A8W4FN02 | 2.3.2.26 | ACT_SITE 1549; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGAAGSQHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFRV... | 65 |
Q2FXI2 | 2.1.1.33 | ACT_SITE 117; /evidence="ECO:0000250" | MRVRYKPWAEDYLKDHPELVDMDGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK | 45 |
G0HV10 | 6.3.4.2 | ACT_SITE 391; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 517; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 519; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605" | MPTEPETDYDPELGRKFIFVTGGVMSGLGKGITAASTGRLLKNAGFDVTAVKIDPYLNVDAGTMNPFQHGEVYVLKDGGEVDLDLGNYERFLDIDMTFDHNVTTGKTYQHVIEKERSGDYLGRTVQIIPHITDDIKRRIREAAEGNDVCIIEVGGTVGDIEGMPYLEALRQFAHEEDEDDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCSDKLDIDTKEKIALFCDVPTEAVFSNPDVDDIYHVPLMVEEEGLDQYVMEELDIATEALPEDERENRWRDLVTQNTEGEVDIALVGKYDLEDAYMSV... | 252 |
A0A1U8AWF3 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSSFRDFISSQMPTMLYCFICFLAISTMASGSTASLKVGFYSSTCPSAEAIVRKAVTKAISQNPGIGAGLIRMHFHDCFVRGCDASVLLDSTPGNDAEKSHPANNPSLRGFEVIDMAKAHIEAVCPQTVSCADIIAFAARDSAYKLGGINYAVPAGRRDGLISRSADIRANLPPPSFTAKQLEDRFAGKGLSLEEMVTLSGAHSIGVSHCSSFLNRLYNFNATHPQDPSMDPDYAAFLKTRCPPTSTAGSSLDPTVPLDVLTPNRLDNKYYKNLKNHHGLLTSDWTLMSSHSTAWMVRNNAKHPSAWASKFAAAMVHMGY... | 14 |
Q9V3D5 | 2.7.12.1 | ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q92630, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLDRCEMPIQLDNEKLRRDVRLSGSRLDLPQLCNGSRRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENI... | 107 |
P87050 | 2.7.11.1 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSTISEVGPWELGLSLGSGGPNSSRLAKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLIDVISAQEQLFVVVEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKPENLYLDAHGSIKIGEFGMASIQQPGKLLQTSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIRSLLLKVCQGQFEMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPFLSCFVHPNISIPIISAPIQPIDPLIVQHLSLVFRCSDDPMPLYEKLASQSPLVEKTLYT... | 99 |
A0A8M9PT21 | 3.1.3.16 | ACT_SITE 1057; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 1059; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MSTCTLLLVSQAGCGLNESLQPCEPPLQTQSCRICRKSKPMGECLECFPSSDLCRCFGERMSFVESNITKYLESSAFFKSEHAEVNMPAELCFDHSEVSGQGDPKKEDQSLERAAESCAEQDTPIDQSTIKLHEVDGLCIENSRINGEFSDQSGSSGYSSLLDSCSEHSESFEASGSSVDLVEMSQNDELSITFDPSDQSEFSEHDEEQLTLSEVSLSDCESFQQDDSEQIVLPEMILDDCDSFEQHNEEPLDASEMSPDLYEFVSFHQDDEEIDLSEMSLVDQDAAEQEDLSDSFQQGHVEPNPLDPLDYETLSECDAE... | 144 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.