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### Instruction:
Are vital Signs Associated with Self-Reported Acute Pain Intensity in the Emergency Department?
### Response:
| Health care professionals cannot use vital signs to estimate or substantiate self-reported pain intensity levels or changes over time. |
### Instruction:
Is generalized Joint Laxity Associated with Primary Occurrence and Treatment Outcome of Lumbar Disc Herniation?
### Response:
| Generalized joint laxity might be associated with lumbar disc herniation occurrence and might also be a negative predictor of worse clinical outcomes after conservative treatment. |
### Instruction:
Does desmopressin treatment improve platelet function under flow in patients with postoperative bleeding?
### Response:
| Desmopressin treatment of patients with bleeding complications after cardiothoracic surgery induces the release of high molecular weight VWF multimers, which enhance platelet activation and thrombus formation under flow conditions. |
### Instruction:
Do the glutathione mimic ebselen inhibits oxidative stress but not endoplasmic reticulum stress in endothelial cells?
### Response:
| These results suggest that ebselen targets only oxidative stress but not ER stress. |
### Instruction:
Do alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats?
### Response:
| When administered to healthy vascular tissue, C. gigas oyster extract inhibits contraction induced by noradrenaline. This effect is likely to be mediated through α-adrenoceptor inhibition, and to a lesser extent, calcium modulating activity. |
### Instruction:
Does the long-term administration of calcineurin inhibitors decrease antioxidant enzyme activity in the rat parotid and submandibular salivary glands?
### Response:
| Based on these results, we suggest that the systemic long-term administration of the calcineurin inhibitor CsA or Tac induces an impairment of the antioxidant enzymatic defense in the rat major salivary glands, which may, in turn, lead to altered saliva composition. |
### Instruction:
Are γ-glutamyl transpeptidase in men and alanine aminotransferase in women the most suitable parameters among liver function tests for the prediction of metabolic syndrome in nonviral hepatitis and nonfatty liver in the elderly?
### Response:
| Among all the different LFTs, γ-GT (>16 U/L) in male and ALT (>21 U/L) in female were the best predictors for the development of MetS in healthy elderly. These two liver markers could be an ancillary test in predicting future MetS development/diagnosis. Elevation of the LFTs without underlying liver diseases should be ... |
### Instruction:
Is bronchiectasis a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis?
### Response:
| Bronchiectasis is an unusual but potent model for the induction of autoimmunity in RA by bacterial infection in the lung. Our study suggests that the ACPA response is not citrulline specific during the early stages of tolerance breakdown but becomes more specific in patients with BR in whom BR/RA develops. |
### Instruction:
Does protein tyrosine phosphatase 1B regulate the activity of retinal pigment epithelial cells?
### Response:
| PTP1B may be involved in regulating the active state of RPE cells. The inhibition of PTP1B promoted the proliferation, myofibroblast differentiation, and migration of RPE cells, and MEK/Erk and PI3K/Akt signaling pathways played important roles in the proliferation and migration process. |
### Instruction:
Does optical coherence tomography enable imaging of tumor initiation in the TAg-RB mouse model of retinoblastoma?
### Response:
| OCT is a non-invasive imaging modality for tracking early TAg-RB tumor growth in vivo. Using OCT, we characterized TAg-positive cells as early as 2 weeks, corresponding to the earliest stages at which tumors are histologically evident, and well before they are evident with funduscopy. Tracking tumor growth from its ear... |
### Instruction:
Does interruption of CD40 Pathway improve Efficacy of Transplanted Endothelial Progenitor Cells in Monocrotaline Induced Pulmonary Arterial Hypertension?
### Response:
| sCD40L impaired protective effects of EPCs. Traditional EPC treatments were limited in PAH, while interruption of CD40 pathway of transplanted cells could apparently improve the therapeutic efficacy. |
### Instruction:
Does third trimester fetal heart rate predict phenotype and mutation burden in the type 1 long QT syndrome?
### Response:
| In this study including 184 fetuses from 2 LQT1 founder populations, third trimester fetal heart rate discriminated between fetal genotypes and correlated with severity of postnatal cardiac phenotype. This finding strengthens the role of fetal heart rate in the early detection and risk stratification of LQTS, particula... |
### Instruction:
Do profile of cochlear implant users of the city of Manaus?
### Response:
| This study allowed us to verify that there are reduced number of cochlear implant recipients in Manaus, but they have met the criteria required by implant centers located in other states of Brazil. |
### Instruction:
Is depression associated with increased incidence of osteoporotic thoracolumbar fracture in postmenopausal women : a prospective study?
### Response:
| Depression is associated with a higher risk of thoracolumbar fracture, with more fracture pain and with lower quality of life in the 2 months following fracture. |
### Instruction:
Is coronary artery calcification score an independent predictor of the no-reflow phenomenon after reperfusion therapy in acute myocardial infarction?
### Response:
| The CAC score is associated with the presence of the NR phenomenon in STEMI patients. |
### Instruction:
Does angiogenic Factors in Cord Blood of Preterm Infants predict Subsequently Developing Bronchopulmonary Dysplasia?
### Response:
| Cord blood level of PlGF, rather than VEGF or sFlt-1, was significantly increased in the BPD group. Consistent with our previous report, cord blood level of PlGF may be considered as a biomarker to predict subsequently developing BPD in preterm infants. |
### Instruction:
Does tREK-1 regulate Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements?
### Response:
| Although cytochalasin D, jasplakinolide and nocodazole altered the F-actin and α-tubulin structures of control and TREK-1 deficient AEC, the changes in cytokine secretion from TREK-1 deficient cells cannot be explained by cytoskeletal rearrangements in these cells. |
### Instruction:
Does iL-9 inhibit HTB-72 melanoma cell growth through upregulation of p21 and TRAIL?
### Response:
| IL-9 inhibits melanoma HTB-72 cell growth by upregulation of p21 and TRAIL. Understanding the interactions between IL-9 and melanoma may help direct strategies for cytokine-based immunotherapy development. |
### Instruction:
Are arterial hypertension and skin allergy risk factors for progression from dengue to dengue hemorrhagic fever : a case control study?
### Response:
| Physicians attending patients with dengue fever should keep those with hypertension or skin allergies in health units to monitor progression for early intervention. This would reduce mortality by dengue. |
### Instruction:
Is infliximab superior to other biological agents for treatment of active ulcerative colitis : A meta-analysis?
### Response:
| All biological agents were superior to placebo for UC treatment in both induction and maintenance phases with a similar safety profile, and infliximab had a better clinical effect than the other biological agents. |
### Instruction:
Is tGF-β1 expression associated with invasion and metastasis of intrahepatic cholangiocarcinoma?
### Response:
| Our data suggest that expression of TGF-β1 is a novel prognostic marker for intrahepatic cholangiocarcinoma. |
### Instruction:
Do gene-expression profiles correlate with the efficacy of anti-EGFR therapy and chemotherapy for colorectal cancer?
### Response:
| We found that gene-expression profiles enabled stratification of CRC patients into four subgroups. The efficacy of anti-EGFR therapy was correlated with component 1 from PCA. This comprehensive study may explain the heterogeneity of unresectable advanced or recurrent CRC and could be useful for identifying novel biomar... |
### Instruction:
Do dietary intakes among South Asian adults differ by length of residence in the USA?
### Response:
| Length of residence in the USA influences diet and nutrient intakes among South Asian adult immigrants and should be considered when investigating and planning dietary interventions to mitigate chronic disease risk. |
### Instruction:
Is intraoperative synovial C-reactive protein as useful as frozen section to detect periprosthetic hip infection?
### Response:
| We found that quantitative SCRP had similar diagnostic value as intraoperative frozen section with comparable sensitivity, specificity, and predictive value in a group of patients undergoing revision total hip arthroplasty. In our institution, SCRP is easier to obtain, less expensive, and less dependent on the techniqu... |
### Instruction:
Does second harmonic generation microscopy reveal altered collagen microstructure in usual interstitial pneumonia versus healthy lung?
### Response:
| Fibrillar collagen's subresolution structure (i.e. "microstructure") is altered in UIP versus COP and healthy lung, which may provide novel insights into the biological reasons why unlike COP, UIP is resistant to therapies, and demonstrates the ability of SHG microscopy to potentially distinguish treatable versus intra... |
### Instruction:
Do disease modifying therapies use associated with comorbid autoimmune diseases in multiple sclerosis patients?
### Response:
| There were no group differences between DMT users vs. DMT naïve subjects with regards to AID frequency. The DMT user group reported the development of an AID earlier than the DMT naïve group. Further studies that can identify patients with higher risk for developing AID׳s is warranted. |
### Instruction:
Does the thyroid hormone receptor β-selective agonist GC-1 affect tolerance to exercise in hypothyroid rats?
### Response:
| Unlike T4, GC-1 in high doses did not modify tolerance to physical exercise in the rats with hypothyroidism. |
### Instruction:
Is risk of hypoglycemia during hemodialysis in diabetic patients related to lower pre-dialysis glycemia?
### Response:
| The use of glucose-free or glucose-poor dialysis solution presents a high risk of intradialytic hypoglycemia in diabetic renal patients, especially in those with presumed better glycemic control. |
### Instruction:
Are thyroid disorders common in first-degree relatives of individuals with type 1 diabetes mellitus?
### Response:
| Thyroid abnormalities seem to be common not only in patients with T1DM but also in their FDR, which suggests that screening strategies for thyroid diseases might also be useful to these individuals. |
### Instruction:
Does functional Polymorphism rs13306560 of the MTHFR Gene be Associated With Essential Hypertension in a Mexican-Mestizo Population?
### Response:
| Our data suggest that the rs13306560 polymorphism of the MTHFR may be part of the observed hypertension process in Mexican-Mestizo populations, but further studies are warranted. In addition, the allele A of the rs13306560 polymorphism as well as the in vitro methylation of CpGs reduced the promoter activity of the MTH... |
### Instruction:
Is low eGFR associated with dysexecutive and amnestic mild cognitive impairment?
### Response:
| At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease. |
### Instruction:
Are elderly donor liver grafts associated with a higher incidence of biliary complications after liver transplantation : results of a national multicenter study?
### Response:
| Transplantation of livers from elderly donors (≥ 65 yr) is not associated with a higher incidence of biliary complications, in a national policy wherein the CIT is kept short. |
### Instruction:
Does two nights of sleep deprivation with or without energy restriction impair the thermal response to cold?
### Response:
| Sleep and energy restriction, at least as evaluated within this experiment, should be considered minimal risk factors for hypothermia. The greater perception of cold discomfort at the same body temperature suggests that sleep and energy restriction may actually reduce cold injury risk, as people are likely to engage ea... |
### Instruction:
Do windscapes shape seabird instantaneous energy costs but adult behavior buffers impact on offspring?
### Response:
| Adults buffered the adverse effect of high winds on chick growth rates by switching to other food sources during windy days or increasing food delivery rates when weather improved. |
### Instruction:
Does survey of coagulation factor concentrate tender and procurement procedures in 38 European Countries?
### Response:
| The involvement of both clinicians and patient organizations greatly improves the outcome of a tender or procurement process, as does the presence of a legal framework that governs the process. |
### Instruction:
Do application of high-frequency electrosurgical scalpel and methylene blue staining in endonasal dacryocystorhinostomy?
### Response:
| A high-frequency electrosurgical scalpel, combined with methylene blue staining of the lacrimal sac, is efficacious for nasal mucosal cutting, intraoperative stanch, and fixation of mucosal flap by cauterization, which significantly alleviates intraoperative complications and enhances surgical success rate. It deserves... |
### Instruction:
Does national Comprehensive Cancer Network Resectability Status for Pancreatic Carcinoma predict Overall Survival?
### Response:
| From the viewpoint of overall survival, the NCCN definition of preoperative resectability status was valid. |
### Instruction:
Does mRI Texture Analysis reveal Deep Gray Nuclei Damage in Amyotrophic Lateral Sclerosis?
### Response:
| TA of T1 weighted images revealed DGN alterations in patients with ALS, namely in the thalami and caudate nuclei. |
### Instruction:
Is mED12 frequently mutated in breast phyllodes tumours : a study of 112 cases?
### Response:
| Similar to fibroadenomas, phyllodes tumours show a high frequency of MED12 mutations, affirming the close biological relationship between these fibroepithelial neoplasms. |
### Instruction:
Does fractalkine receptor chemokine ( CX3CR1 ) influence on cervical and lumbar disc herniation?
### Response:
| This study identified that increases in CX3CL1 and CX3CR1-expressing cells are significantly related to pathomechanism of HNP for the first time. Especially, CD4 (+) T-cells and NK cells expressing CX3CR1 may play an important role in developing C-HNP. |
### Instruction:
Does the baseline diameter of the inferior vena cava measured by sonography increase with age in normovolemic children?
### Response:
| This pilot study of sonographic measurements of the IVC diameter in normovolemic children suggests a statistically significant positive correlation between age and IVC diameter. Future studies should focus on multicenter enrollment, children in the youngest age group, and the development of normative growth curves for ... |
### Instruction:
Does calcium Plus Vitamin D Supplementation During the Third Trimester of Pregnancy in Adolescents Accustomed to Low Calcium Diets Affect Infant Bone Mass at Early Lactation in a Randomized Controlled Trial?
### Response:
| Calcium and vitamin D supplementation of the adolescents studied resulted in higher fetal body weight at 36 wk of gestation and had no effect on infant bone mass at 5 wk postpartum. Because correlations between maternal and infant bone mass were evident only in the placebo group, infant bone mass appeared to be more de... |
### Instruction:
Does bovine Colostrum modulate Myeloablative Chemotherapy-Induced Gut Toxicity in Piglets?
### Response:
| BC may reduce gut toxicity during myeloablative chemotherapy in piglets by preserving intestinal function and reducing inflammation. Whether similar effects occur in children remains to be tested. |
### Instruction:
Do monocytosis and a Low Lymphocyte to Monocyte Ratio Are Effective Biomarkers of Ulcerative Colitis Disease Activity?
### Response:
| Monocytosis and a low L/M ratio might be effective, readily available, and low-cost biomarkers to identify disease activity in UC patients. N/L values were more effective in distinguishing active UC patients from patients without IBD and those with C. difficile infection. |
### Instruction:
Is transcriptional upregulation of microtubule-associated protein 2 involved in the protein kinase A-induced decrease in the invasiveness of glioma cells?
### Response:
| Our findings suggested that PKA may represent a potential target for anti-invasion glioma therapy and that the downstream modulators (eg, STAT3/MAP2) partially mediate the effects of PKA. |
### Instruction:
Does expression of bone morphogenetic protein-2 and -7 in urinary bladder cancer predict time to tumor recurrence?
### Response:
| Low expression of BMP2 and BMP7 is associated with shorter time to recurrence. The BMP expression levels are not indicative of tumor stage. |
### Instruction:
Is renal access through the inferior calyx associated with higher risk of severe bleeding after percutaneous nephrolithotomy?
### Response:
| Severe postoperative bleeding after PCNL is associated with renal puncture via the inferior calyx, multiple renal stones and solitary kidney stones. |
### Instruction:
Are microvascular obstruction and endothelial activation independently associated with the clinical manifestations of severe falciparum malaria in adults : an observational study?
### Response:
| Microvascular obstruction and systemic endothelial activation are independently associated with plasma lactate, the strongest predictor of death in adults with falciparum malaria. This supports the hypothesis that the two processes make an independent contribution to the pathogenesis and clinical manifestations of the ... |
### Instruction:
Does laparoscopic sleeve gastrectomy lead the U.S. utilization of bariatric surgery at academic medical centers?
### Response:
| Within the context of U.S. academic medical centers, there has been a significant increase in the utilization of laparoscopic sleeve gastrectomy, which has surpassed laparoscopic gastric bypass utilization since 2013. Laparoscopic sleeve gastrectomy is now the most commonly performed bariatric procedure at the national... |
### Instruction:
Is the significant inhibition on CYP3A caused by radix Aconiti single herb observed in the Wutou decoction : The necessity of combination therapy of radix Aconiti?
### Response:
| PWT can significantly inhibit CYP3A activity ex vivo at the tested doses because of the down-regulation of CYP3A protein and mRNA expression levels. WTD can significantly reverse the inhibition caused by PWT. WTD also had no significant effect on CYP3A activity in vivo. Results implied that the use of PWT as a part of ... |
### Instruction:
Does tumor-induced loss of mural Connexin 43 gap junction activity promote endothelial proliferation?
### Response:
| Our data indicate that i) functional Cx43 is required for mural cell-induced endothelial quiescence, and ii) downregulation of Cx43 GJ by tumors frees endothelium to respond to angiogenic cues. These data define a novel and important role for maintained Cx43 function in regulation of vessel quiescence, and suggest its ... |
### Instruction:
Does nMR-based metabolomics highlight differences in plasma metabolites in pigs exhibiting diet-induced differences in adiposity?
### Response:
| These data indicate that metabolites associated with energy and protein metabolism were involved in the response to a high-fat, high-fibre diet. Relevant plasma indicators of metabolic flexibility related to changes in body adiposity were then proposed. |
### Instruction:
Is luciferase expression driven by the promoter of fibroblast activation protein-α in murine pulmonary fibrosis?
### Response:
| Fluorescence intensity reflects the degree of pulmonary fibrosis in FAPα-p-luc mice. and this mouse model may be used to investigate molecular mechanisms and drug screening of pulmonary fibrosis. |
### Instruction:
Does increased aortic tortuosity indicate a more severe aortic phenotype in adults with Marfan syndrome?
### Response:
| Increased ATI is associated with a more severe aortic phenotype in MFS patients. |
### Instruction:
Does transposon Mutagenesis Screen identify Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor?
### Response:
| This study identifies many novel candidate genetic drivers of lung cancer and demonstrates that CUL3 acts as a tumor suppressor by regulating oxidative stress. |
### Instruction:
Does serum quantitative proteomic analysis reveal potential zinc-associated biomarkers for nonbacterial prostatitis?
### Response:
| Our findings suggest that SOD3 and CA1 are potential diagnostic markers of nonbacterial prostatitis, although further large-scale studies are required. The molecular profiles of nonbacterial prostatitis pathogenesis may lay a foundation for discovery of new therapies. |
### Instruction:
Does pLA2G16 Expression in Human Osteosarcoma be Associated with Pulmonary Metastasis and Poor Prognosis?
### Response:
| This study indicated that PLA2G16 expression is a significant prognostic factor in primary osteosarcoma patients for predicting the development of metastases and poor survival. |
### Instruction:
Does protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid decline with age?
### Response:
| PpIX formation in human skin declines with age. No explanation could be attributed to skin phototype, stratum corneum hydration or UV damage. The consequence might be reduced efficacy of PDT in the elderly. |
### Instruction:
Does down-regulation of miR-23b induce phenotypic switching of vascular smooth muscle cells in vitro and in vivo?
### Response:
| We identify miR-23b as a novel regulator of VSMC phenotypic switch in vitro and following vascular injury in vivo. |
### Instruction:
Does vybrant DyeCycle Violet Stain discriminate Two Different Subsets of CD34+ Cells?
### Response:
| DCV staining may be used to discriminate subsets of CD34+ cells similarly to other methods which have previously defined different functional properties that can be related to the characterization, resolution, and purification of primitive hematopoietic stem cells in combination with specific useful markers for multico... |
### Instruction:
Are mineral metabolism disturbances associated with the presence and severity of calcific aortic valve disease?
### Response:
| This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism. |
### Instruction:
Is meta-analysis of C242T polymorphism in CYBA genes : risk of acute coronary syndrome lower in Asians but not in Caucasians?
### Response:
| Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians. |
### Instruction:
Does pitavastatin calcium improve endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia?
### Response:
| Treatment with pitavastatin calcium exerted favorable effects on endothelial function and arterial stiffness. It also improved carotid atherosclerosis in patients with HC. |
### Instruction:
Does intraneural GJB1 gene delivery improve nerve pathology in a model of X-linked Charcot-Marie-Tooth disease?
### Response:
| Gene delivery using a lentiviral vector leads to efficient gene expression specifically in Schwann cells. Restoration of Cx32 expression ameliorates nerve pathology in a disease model and provides a promising approach for future treatments of CMT1X and other inherited neuropathies. |
### Instruction:
Does combining odours isolated from phylogenetically diverse sources yield a better lure for yellow jackets?
### Response:
| The new lures are comprised of compounds from animals, plants and fungi, thus targeting the omnivorous behaviour of these wasps. |
### Instruction:
Does retention time of chlorophacinone in black-tailed prairie dogs inform secondary hazards from a prairie dog rodenticide bait?
### Response:
| The results suggest that the greatest risk of secondary toxicity occurs ≤14 days post-application of Rozol Prairie Dog Bait and declines thereafter. This corresponds to the time when chlorophacinone residues are high, and prairie dogs exhibit signs of intoxication and are perhaps most susceptible to predation and scave... |
### Instruction:
Does [ Sodium ferulate protect against daunorubicin-induced cardiotoxicity in juvenile rats ]?
### Response:
| SF treatment could alleviate the decreasing of cardiac reservation induced by DNR damages in juvenile rats, which might be related to its reversing the effects on the cardiac systolic and diastolic function injuries and its inhibiting effects on the decreasing of cTNI expression caused by DNR. The mechanism of SF preve... |
### Instruction:
Does black cohosh improve objective sleep in postmenopausal women with sleep disturbance?
### Response:
| In early postmenopausal women with a major sleep complaint, black cohosh effectively improved sleep and might be a safe measure in managing menopausal sleep disturbance. |
### Instruction:
Is pTEN loss associated with follicular variant of Middle Eastern papillary thyroid carcinoma?
### Response:
| Our study confirmed that PTEN might have a role in pathogenesis in a subset of PTC. PTEN loss of protein expression is a more common event in follicular variant of papillary thyroid cancer. Lack of association between PTEN loss of protein expression and PTEN gene deletion might indicate that gene deletion may not be th... |
### Instruction:
Is kPNA2 a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer?
### Response:
| This study provides further evidence for the complexity of DDR mechanism in BC, and that KNPA2 has a role in the aberrant subcellular localisation of DDR proteins with subsequent impaired function. |
### Instruction:
Does stimulation of endothelial non-neuronal muscarinic receptor attenuate the progression of atherosclerosis via inhibiting endothelial cells activation?
### Response:
| Our results indicate that arecoline attenuates the progression of atherosclerosis and inhibits endothelial cells activation and adherence by stimulating endothelial NNMR. These effects, at least in part, are due to its modulation on NF-κB activity. |
### Instruction:
Are patients with migraine right about their perception of temperature as a trigger : time series analysis of headache diary data?
### Response:
| This diary-based study provides evidence to link the perception of temperature sensitivity and headache incidence in migraine patients. Those who reported temperature sensitivity are more likely to have headache increase during the winter, particular for mild headaches. |
### Instruction:
Is sLCO1B1 polymorphism associated with risk of statin-induced myalgia/myopathy in a Czech population?
### Response:
| In Czech patients treated with low statin doses, there is no association between SLCO1B1 gene polymorphism and risk of myalgia/myopathy. |
### Instruction:
Is esophagogastric junction morphology associated with a positive impedance-pH monitoring in patients with GERD?
### Response:
| Increasing separation between LES and CD can cause a gradual and significant increase in reflux. EGJ morphology may be useful to estimate an abnormal impedance-pH testing in GERD patients. |
### Instruction:
Is which the best repair of articular-sided rotator cuff tears : a meta-analysis?
### Response:
| In conclusion, the meta-analysis suggests that the trans-tendon technique is better than the tear conversion followed by repair technique with regard to the management of articular-sided PTRCTs of more than 50% thickness in the re-tear rate aspect. |
### Instruction:
Is `` Forty the new twenty '' : An analysis of British media portrayals of older mothers?
### Response:
| Delayed childbearing was represented positively, as it facilitated conformity with dominant ideologies surrounding motherhood. Within these boundaries, the effects of age were disregarded. This study provides evidence of restrictive framing of the issues surrounding delayed childbearing in the UK media which militate a... |
### Instruction:
Are bisphenol-A plasma levels related to inflammatory markers , visceral obesity and insulin-resistance : a cross-sectional study on adult male population?
### Response:
| Detectable BPA plasma levels have been found also in our population. The strictly association between BPA and WC, components of MS, and inflammatory markers, further supports the BPA role in visceral obesity-related low grade chronic inflammation. |
### Instruction:
Does microRNA-26a suppress recruitment of macrophages by down-regulating macrophage colony-stimulating factor expression through the PI3K/Akt pathway in hepatocellular carcinoma?
### Response:
| miR-26a expression reduced M-CSF expression and recruitment of macrophages in HCC. |
### Instruction:
Does integrative modeling reveal the principles of multi-scale chromatin boundary formation in human nuclear organization?
### Response:
| We show that integrative modeling of large chromatin dataset collections using random forests can generate useful insights into chromosome structure. The models produced recapitulate known biological features of the cell types involved, allow exploration of the antecedents of higher-order structures and generate testab... |
### Instruction:
Is low-normal serum potassium associated with an increased risk of cardiovascular and all-cause death in community-based elderly?
### Response:
| Our findings suggest that low-normal SK may be used as a marker of poor survival for elderly outpatient cares. |
### Instruction:
Does routine Preoperative Liver-specific Magnetic Resonance Imaging Exclude the Necessity of Contrast-enhanced Intraoperative Ultrasound in Hepatic Resection for Colorectal Liver Metastasis?
### Response:
| CE-IOUS is useful in hepatic resection for CRLM, even if EOB-MRI and CE-CT are performed. |
### Instruction:
Are toll-like receptor 3 gene polymorphisms associated with the risk of hepatitis B and hepatitis C virus infection?
### Response:
| This genetic analysis revealed the absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection. |
### Instruction:
Do an update on pharmacotherapy for the treatment of fibromyalgia?
### Response:
| Different drugs are recommended for the treatment of fibromyalgia by different published guidelines, although only three of them have been approved for this indication by the US FDA, and none have been approved by the European Medicines Agency. According to the available evidence, pregabalin, duloxetine and milnacipran... |
### Instruction:
Do sequence-based ultra-dense genetic and physical maps reveal structural variations of allopolyploid cotton genomes?
### Response:
| We report the genotype-by-sequencing method used to identify millions of SNPs between G. hirsutum and G. barbadense. We construct and use an ultra-dense SNP map to correct sequence mis-assemblies, merge scaffolds into pseudomolecules corresponding to chromosomes, detect genome rearrangements, and identify centromeric r... |
### Instruction:
Is surgical diverticulitis associated with defects in the expression of wound healing genes?
### Response:
| The lack of significant alteration in mRNA expression of traditionally associated wound healing genes/proteins in young SD patients suggests that such genes play a minor role in the genetic predisposition to youthful diverticulitis. |
### Instruction:
Does profusion of Opacities in Simple Coal Worker 's Pneumoconiosis be Associated With Reduced Lung Function?
### Response:
| We observed progressively lower lung function across the range of small-opacity profusion. These findings address a long-standing question in occupational medicine and point to the importance of medical surveillance and respiratory disease prevention in this workforce. |
### Instruction:
Is inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin associated with increased sirtuin 1 activity in mice?
### Response:
| Dietary intake of luteolin prevents alcohol promoted pre-neoplastic lesions, potentially mediated by SIRT1 signaling pathway. |
### Instruction:
Does exome sequencing identify complex I NDUFV2 mutations as a novel cause of Leigh syndrome?
### Response:
| We have identified NDUFV2 mutations in two families with Complex I deficiency, including a novel mutation. The diagnosis of Leigh syndrome expands the clinical phenotypes associated with the c.IVS2 + 1delGTAA mutation in this gene. |
### Instruction:
Do [ The effection of environmental and health message forecasting service offer to the allergic rhinitis in children ]?
### Response:
| It can significantly increase the degree of attention of parents of children with AR that the parents of children record daily symptom scores of AR of children everyday, while the doctors send the short message to the parents by using meteorological environment warning forecast technology to tell the parents the risk o... |
### Instruction:
Does cSF tau correlate with CJD disease severity and cognitive decline?
### Response:
| The correlation between tau levels and the disease severity and degree of cognitive decline in patients with fCJD suggests that tau can be a biomarker reflecting the extent of neuronal damage. |
### Instruction:
Is positive hepatitis B surface antibody associated with reduced risk of diabetes mellitus in retired female Chinese workers?
### Response:
| An HBsAb-positive status is associated with a low rate of diabetes and better metabolic status. A prospective study of patients with known vaccination records is needed to investigate whether hepatitis B virus vaccination could protect against the development of diabetes. |
### Instruction:
Does matrix Gla protein regulate calcification of the aortic valve?
### Response:
| An important anti-calcification defense mechanism is deficient in calcified aortic valves. MGP expression is significantly lower in diseased relative to normal AVICs. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve. |
### Instruction:
Do interlead anatomic and electrical distance predict outcome in CRT patients?
### Response:
| The interlead anatomic and electrical distance are strongly and independently associated with patient outcome after CRT implantation. The 2 measures show an additive predictive value. (CRT MORE: Cardiac Resynchronization Therapy Modular Registry; www.clinicaltrials.gov, unique identifier: NCT01573091.) |
### Instruction:
Does the endogenous molecular clock orchestrate the temporal separation of substrate metabolism in skeletal muscle?
### Response:
| These data provide evidence that the intrinsic molecular clock in skeletal muscle temporally regulates genes involved in the utilization and storage of substrates independent of circadian activity. Disruption of this mechanism caused by phase shifts (that is, social jetlag) or night eating may ultimately diminish skele... |
### Instruction:
Are nTRK2 expression levels reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder?
### Response:
| These studies demonstrate a unique pathology of neocortical pyramidal neurons of the ACC in ASD. NTRK2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. Reduced pyramidal neuron NTRK2 expression in the ACC cou... |
### Instruction:
Do sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals?
### Response:
| Rescue of Y-linked gene loss through transposition to autosomes has previously been reported for a single isolated rodent species. However, our findings indicate that this compensatory mechanism is widespread among mammalian species. Thus, Y-linked gene loss emerges as an additional driver of gene transposition from th... |
### Instruction:
Does peripheral interleukin-6 promote resilience versus susceptibility to inescapable electric stress?
### Response:
| The results suggest that peripheral IL-6 may contribute to resilience versus susceptibility to inescapable stress. |
### Instruction:
Is normal-weight obesity associated with increased risk of subclinical atherosclerosis?
### Response:
| NWO individuals carry a higher incidence of subclinical atherosclerosis compared with NWL individuals, regardless of other clinical risk factors for atherosclerosis. |
### Instruction:
Is chronic intermittent hypoxia independently associated with reduced postoperative opioid consumption in bariatric patients suffering from sleep-disordered breathing?
### Response:
| Preoperative nocturnal intermittent hypoxia may enhance sensitivity to opioids. |
### Instruction:
Are mid-regional-pro-adrenomedullin plasma levels increased in obese adolescents?
### Response:
| Our study shows for the first time that obese adolescents have higher circulating levels of MR-proADM compared with normal-weight, appropriate controls suggesting its important involvement in obese patients. |
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