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### Instruction:
Does assessment method influence the severity and type of symptoms reported after self-reported mild traumatic brain injury?
### Response:
| Assessment method can alter the number, severity, and types of symptoms reported by individuals who have sustained an mTBI and could potentially influence clinical decisions. |
### Instruction:
Does prior Innominate Vein Occlusion Preclude Successful Bidirectional Superior Cavopulmonary Connection?
### Response:
| Although patients with prior upper-body venous obstruction may have lower systemic oxygen saturations at hospital discharge, they do not demonstrate an increased SCPC failure or mortality rate. Innominate vein occlusion or its equivalent in patients with bilateral SVCs should not preclude the performance of SCPC. Physi... |
### Instruction:
Do feasibility of three-dimensional ultrashort echo time magnetic resonance imaging at 1.5 T for the diagnosis of skull fractures?
### Response:
| UTE MRI sequences are feasible for the evaluation of skull structures and fractures, with no radiation exposure, particularly for paediatric and pregnant patients. |
### Instruction:
Are markers of renal disease and function associated with systemic inflammation in HIV infection?
### Response:
| Renal disease and function were associated with systemic inflammation in HIV infection, both before and after ART. Systemic inflammation may partially explain the relationships between proteinuria, albuminuria, and reduced renal function and future adverse outcomes. |
### Instruction:
Does erythropoietin promote peripheral nerve regeneration in rats by upregulating expression of insulin-like growth factor-1?
### Response:
| Erythropoietin may promote peripheral nerve repair in a rat model of sciatic nerve injury through the upregulation of IGF-1 expression. These findings reveal a novel mechanism underlying the neurotrophic effects of EPO. |
### Instruction:
Does quercetin protect against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress?
### Response:
| Quercetin pretreatment effectively ameliorates LPS-induced ALI, largely through suppression of inflammation and oxidative stress, and may thus have therapeutic potential in the prevention of this disease. |
### Instruction:
Are low blood and vitreal BDNF , LXA4 and altered Th1/Th2 cytokine balance potential risk factors for diabetic retinopathy?
### Response:
| This study reports that low serum BDNF and higher IL-6 levels are potential risk factors for DR in type 2 DM. This study supports the role of BDNF in modulating the pro- and anti-inflammatory cytokines, and low level of BDNF is associated with development of diabetic retinopathy. |
### Instruction:
Does fish oil-derived n-3 PUFA therapy increase muscle mass and function in healthy older adults?
### Response:
| Fish oil-derived n-3 PUFA therapy slows the normal decline in muscle mass and function in older adults and should be considered a therapeutic approach for preventing sarcopenia and maintaining physical independence in older adults. This study was registered at clinicaltrials.gov as NCT01308957. |
### Instruction:
Does [ Resistance exercise improve serum lipids in adult women ]?
### Response:
| The high intensity and low volume training improved plasma lipid profile in this group of women. |
### Instruction:
Does airway Hyperreactivity be Delayed after Mild Neonatal Hyperoxic Exposure?
### Response:
| These data demonstrate that early mild hyperoxia exposure causes a delayed augmentation of airway reactivity, suggesting a long-term alteration in the trajectory of airway smooth muscle development and consistent with resultant symptomatology. |
### Instruction:
Do intrathoracic pressure swings induced by simulated obstructive sleep apnoea promote arrhythmias in paroxysmal atrial fibrillation?
### Response:
| Simulated OSA induces APBs which may be important in patients with PAF, because the majority of episodes of PAF has been shown to be triggered by APBs. Simulated OSA leads to a significant prolongation of ventricular repolarization. |
### Instruction:
Does tobacco differentially affect the clinical-biological phenotypes of ANCA-associated vasculitides?
### Response:
| These results suggest that tobacco use could differentially affect GPA and EGPA clinical-biological phenotypes, and support the role of environmental exposures in AAV development and its phenotype. |
### Instruction:
Does prophylactic Interleukin-2 Treatment prevent Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis?
### Response:
| Our data show that prophylactic IL-2 treatment prevents fetal intestinal inflammation and mucosal injury in the context of experimental chorioamnionitis. Modulation of the Treg/Teff cell balance may contribute to the protective effects of IL-2. |
### Instruction:
Does tiotropium attenuate IL-13-induced goblet cell metaplasia of human airway epithelial cells?
### Response:
| We demonstrate that tiotropium has no effects on epithelial cell differentiation after air exposure, but inhibits and reverses IL-13-induced goblet cell metaplasia, possibly via FoxA2 and FoxA3. This indicates that non-neuronal acetylcholine contributes to goblet cell differentiation by a direct effect on epithelial ce... |
### Instruction:
Does lower limb ice application alter ground reaction force during gait initiation?
### Response:
| These results suggest that although caution is necessary when performing activities that require good gait control, the application of ice to the ankle, sole of the foot or calf in 30-minute intervals may be safe even preceding such activities. |
### Instruction:
Do prognostic value of initial elevation in cardiac troponin I level in critically ill patients without acute coronary syndrome?
### Response:
| Critically ill patients without acute coronary syndrome with elevated levels of cardiac troponin I at admission had higher mortality and more intubations than did control patients. |
### Instruction:
Does low-level laser therapy alleviate mechanical and cold allodynia induced by oxaliplatin administration in rats?
### Response:
| The findings of this study support LLLT as a potential treatment for oxaliplatin-induced neuropathy. Moreover, our findings suggest that SP, TRPM8, and NGF proteins in the superficial dorsal horn and DRG may be involved in an antiallodynic effect for LLLT. |
### Instruction:
Are standard dose and prolonged administration of azacitidine associated with improved efficacy in a real-world group of patients with myelodysplastic syndrome or low blast count acute myeloid leukemia?
### Response:
| Our data show that maximal azacitidine efficacy is associated with the standard dose and with prolonged treatment, beyond 4-6 cycles, with the goal of also improving the 'quality' of response. Lower MDS-CI and IPSS-R scores, hematologic response and disease stability, are associated with longer survival. The risk of fe... |
### Instruction:
Is compression anastomotic ring-locking procedure ( CARP ) a safe and effective method for intestinal anastomoses following left-sided colonic resection?
### Response:
| Our results indicate that the novel suture-less CARP is a safe and effective method for creating colonic anastomoses. Further studies are warranted in larger patient populations to compare CARP head-on-head with stapled and/or hand-sewn colonic anastomoses. |
### Instruction:
Does north American trial result at 1 year with the Sorin Freedom SOLO pericardial aortic valve?
### Response:
| The Freedom SOLO stentless pericardial aortic valve demonstrated excellent haemodynamics and a good safety profile out to the 1 year of follow-up. |
### Instruction:
Does understandability of Speech predict Quality of Life Among Maxillectomy Patients Restored With Obturator Prosthesis?
### Response:
| The results of this study showed that understandability of speech was the only predictor of overall QoL scores. |
### Instruction:
Do female adolescents with severe substance and conduct problems have substantially less brain gray matter volume?
### Response:
| Female adolescents with severe substance and conduct problems in comparison to similarly aged female healthy controls showed substantially lower gray matter volume in brain regions involved in inhibition, conflict processing, valuation of outcomes, decision-making, reward, risk-taking, and rule-breaking antisocial beha... |
### Instruction:
Are vitamin D serum levels associated with handgrip strength but not with muscle mass or length of hospital stay after hip fracture?
### Response:
| In conclusion, vitamin D serum levels were associated with handgrip strength but not with muscle mass or length of hospital stay after hip fracture. |
### Instruction:
Does autosomal dominant hereditary spastic paraplegia with axonal sensory motor polyneuropathy map to chromosome 21q 22.3?
### Response:
| We present the clinical and genetic analysis of an American family with autosomal dominant HSP with axonal sensory motor polyneuropathy mapping to a novel locus on chromosome 21q22.3 designated SPG56. |
### Instruction:
Does lutein suppress inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia?
### Response:
| These results suggest that lutein attenuates neuroinflammation in LPS-activated BV-2 microglia partly through inhibiting p38-, JNK-, and Akt-stimulated NF-κB activation and promoting ERK-induced Nrf2 activation, suggesting that lutein has great potential as a nutritional preventive strategy in inflammation-related neur... |
### Instruction:
Do dutch neonatologists have adopted a more interventionist approach to neonatal care?
### Response:
| Terminations increased after changes in healthcare regulations. Modes of death in the NICU remained similar over 10 years. The increased duration of NICU treatment before dying suggests a more interventionist approach to treatment in 2008-2010. |
### Instruction:
Does inflammatory pain memory facilitate occlusal interference-induced masticatory muscle hyperalgesia in rats?
### Response:
| Inflammatory pain memory facilitated occlusal interference-induced masseter muscle pain. |
### Instruction:
Does late INa increase diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII?
### Response:
| Late INa exerts distinct effects on Ca(2+) homeostasis in atrial myocardium through activation of CaMKII and PKA. Inhibition of late INa represents a potential approach to attenuate CaMKII activation and decreases SR-Ca(2+)-leak in atrial rhythm disorders. The interconnection with the cAMP/PKA system further increases ... |
### Instruction:
Does slit2 modify VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity?
### Response:
| Combining Slit2 with VEGFs adjusts VEGFR2-mediated angiogenic effects into a more physiological direction. This possibly allows the use of higher VEGF vector doses to achieve a more widespread vector and VEGF distribution in the target tissues leading to a better therapeutic outcome while reducing excess vascular perme... |
### Instruction:
Does sevoflurane suppress hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α?
### Response:
| Sevoflurane could suppress hypoxia-induced growth and metastasis of lung cancer cells, which might be associated with modulating HIF-1α and its down-stream genes. Moreover, p38 MAPK signaling pathway was involved in the regulation of HIF-1α by sevoflurane. |
### Instruction:
Does ketamine cause mitochondrial dysfunction in human induced pluripotent stem cell-derived neurons?
### Response:
| We established an in vitro model for assessing the neurotoxicity of ketamine in iPSC-derived neurons. The present data indicate that the initial mitochondrial dysfunction and autophagy may be related to its inhibitory effect on the mitochondrial electron transport system, which underlies ketamine-induced neural toxicit... |
### Instruction:
Do podocyte structural parameters predict progression to diabetic nephropathy in normoalbuminuric type 1 diabetic patients?
### Response:
| This study does not indicate that podocyte structural changes are preconditions for later DN progression in initially normoalbuminuric type 1 diabetic patients. However, this does not preclude an important role for podocyte injury at a later stage of DN. |
### Instruction:
Does low Serum Vitamin D be Independently Associated with Larger Lesion Volumes after Ischemic Stroke?
### Response:
| Low serum 25(OH)D was independently associated with larger ischemic infarct volume, which may partially explain observed worse outcomes in ischemic stroke patients with poor vitamin D status. Although causality remains to be proven, our results provide the rationale to further explore vitamin D as a promising marker fo... |
### Instruction:
Do effects of implant morphology on rotational stability during immediate implant placement in the esthetic zone?
### Response:
| Within the confines of this study, the use of a tapered implant with an FD-IDD of ≥ 0.5 mm minimized the incidence of rotational implant instability for the IIPP procedure. |
### Instruction:
Does high glucose promote TGF-β1 production by inducing FOS expression in human peritoneal mesothelial cells?
### Response:
| FOS is a downstream effector of HG stimulation in HPMCs that contributes to TGF-β1 production, suggesting that blocking FOS expression may be a therapeutic target for peritoneal fibrosis. |
### Instruction:
Does a novel triterpene from Astraeus hygrometricus induce reactive oxygen species leading to death in Leishmania donovani?
### Response:
| We claim the present invention as substantial in depth evidences that mushroom derived active molecules can be exploited as target specific, comparatively nontoxic leads for antileishmanial therapy. |
### Instruction:
Does low-Protein Diet-Induced Fetal Growth Restriction lead to Exaggerated Proliferative Response to Vascular Injury in Postnatal Life?
### Response:
| These results suggest that maternal low-protein diet-induced FGR increases susceptibility of the vasculature to postnatal injury. |
### Instruction:
Do isotopic evidence for dietary niche overlap between barking deer and four-horned antelope in Nepal?
### Response:
| Barking deer and four-horned antelope both are browsers; their dietary sources overlapped during monsoon but differed during the dry season. Conservation actions focused on resource management during the dry season to reduce food scarcity and competition over limited resources is likely to be the most effective. |
### Instruction:
Does nexrutine inhibit cancer cell growth as a consequence of mitochondrial damage and mitophagy?
### Response:
| Our study revealed that autophagy plays an important role in the inhibition of cancer cell proliferation by Nexrutine. |
### Instruction:
Does periostin mediate TGF-β-Induced Epithelial Mesenchymal Transition in Prostate Cancer Cells?
### Response:
| Our findings indicate that periostin is an important mediator of TGF-β-induced EMT and suggest that periostin is a potential therapeutic target for suppressing the metastatic progression of prostate cancer. |
### Instruction:
Does normobaric Intermittent Hypoxia over 8 Months Reduce Body Weight and Metabolic Risk Factors -- a Randomized , Single Blind , Placebo-Controlled Study in Normobaric Hypoxia and Normobaric Sham Hypoxia?
### Response:
| Long-term, moderate intensity exercise and rest in hypoxia does not lead to higher reductions in body weight than normoxia alone. Therefore, for weight loss and metabolic markers hypoxic exposure does not add effects at least when stimuli (i.e., hypoxia dose, exercise intensity/duration) are unaltered throughout the in... |
### Instruction:
Does pTK6 potentiate Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer?
### Response:
| PTK6 affects cell cycle and DNA damage, thus making it an important therapeutic target to improve the outcomes of patients with pancreatic cancer. |
### Instruction:
Does brimonidine reduce TGF-beta-induced extracellular matrix synthesis in human Tenon 's fibroblasts?
### Response:
| Our data revealed that brimonidine reduces TGF-β-induced ECM synthesis in human Tenon's fibroblasts in vitro. This finding implies that topical administration of brimonidine may be helpful in reducing the fibrosis caused by the long-term use of topical anti-glaucoma medications. |
### Instruction:
Do outcomes in HIV/HBV-Coinfected Patients in the Tenofovir Era Are Greatly Affected by Immune Suppression?
### Response:
| Mortality was high and most often unrelated to liver disease in this HIV/HBV-Coinfected cohort treated predominantly with TDF-containing HAART. Optimal CD4 counts predicted survival and the achievement of HBV virological end points. Tenofovir prevented liver decompensation but not HCC, which was the predominant cause o... |
### Instruction:
Is aBCB1 C3435T polymorphism associated with leukemia susceptibility : evidence from a meta-analysis?
### Response:
| The meta-analysis suggests that ABCB1 C3435T polymorphism is associated with increased risk of leukemia. |
### Instruction:
Are eicosapentaenoic acid and docosapentaenoic acid monoglycerides more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model?
### Response:
| Altogether, the present data suggest that MAG-EPA, without vitamin E, represents a new potential therapeutic strategy for resolving inflammation in arthritis. |
### Instruction:
Does aspects correlate with Scandinavian Stroke Scale for predicting early neurological impairment?
### Response:
| The SSS can predict worst neurological impairment when associated with lower values of ASPECTS. |
### Instruction:
Does exercise alter myostatin protein expression in sedentary and exercised streptozotocin-diabetic rats?
### Response:
| These results demonstrate that exercise can modulate the muscle expression of MSTN protein in diabetic rats and suggest that MSTN may be involved in energy homeostasis. |
### Instruction:
Does triiodothyronine modulate the expression of leptin and adiponectin in 3T3-L1 adipocytes?
### Response:
| These results demonstrated fast actions of triiodothyronine on the leptin and adiponectin expression, starting at 0.5 hour, at a dose of 1,000nM for leptin and 100nM for adiponectin. Triiodothyronine stimulated or inhibited the expression of adipokines in adipocytes at different times and doses which may be useful to a... |
### Instruction:
Are serum leptin levels independently related to the incidence of ischemic heart disease in a prospective study of patients with type 2 diabetes?
### Response:
| Our data support the use of serum leptin in type 2 diabetes to add independent prognostic information in terms of ischemic heart disease when compared with traditional cardiovascular risk factors. In the men of the cohort this prognostic information was in addition also to data on IMT and PWV, two non-invasive measurem... |
### Instruction:
Is health-related quality of life associated with stroke deficits in older adults?
### Response:
| we found that impaired HRQoL was significantly associated with the number and type of stroke deficits in older adults with a history of stroke. |
### Instruction:
Is azithromycin more allergenic than clarithromycin in children with suspected hypersensitivity reaction to macrolides?
### Response:
| A complete allergy workup enabled us to confirm a diagnosis of clarithromycin and azithromycin allergy in 15.5% and 47.3% of cases, respectively. Azithromycin was more allergenic than clarithromycin in children. |
### Instruction:
Does a novel lead design enable selective deep brain stimulation of neural populations in the subthalamic region?
### Response:
| From the model simulations we conclude that the HD lead in steering-mode with optimized stimulation parameter selection can stimulate more STN cells. Next, the clinical impact of the increased number of activated STN cells should be tested and balanced across the increased complexity of identifying the optimized stimul... |
### Instruction:
Does endomyocardial expression of SDF-1 predict mortality in patients with suspected myocarditis?
### Response:
| Endomyocardial expression of SDF-1 is enhanced in inflammatory cardiomyopathy, positively correlates with myocardial fibrosis and identifies high-risk patients with suspected myocarditis. |
### Instruction:
Is a deletion at ADAMTS9-MAGI1 locus associated with psoriatic arthritis risk?
### Response:
| The present genome-wide scan for CNVs associated with PsA risk has identified a new deletion associated with disease risk and which is also differential from PsC risk. |
### Instruction:
Does circulating Fibroblast Growth Factor 23 have a U-Shaped Association With Atrial Fibrillation Prevalence?
### Response:
| Serum FGF23 had a U-shaped relationship with prevalence of AF among Japanese cardiac patients, which was independent of other calcium/phosphate metabolism-related parameters and eGFR. Pathophysiology underlying the observed link, if at all, awaits further investigation. |
### Instruction:
Does [ Betaine-enriched beet suppress hyperhomocysteinemia induced by choline deficiency in rats ]?
### Response:
| The results indicated that betaine or beet could completely suppress the hyperhomocysteinemia induced by choline deficiency resulting from stimulating the homocysteine removal by both remethylation and cystathionine formation. |
### Instruction:
Are increased CCL17 serum levels associated with improved survival in advanced melanoma?
### Response:
| Serum levels of CCL17 and S100B represent independent prognostic markers for melanoma patients with distant metastases. These biomarkers were more powerful than the M category according to the AJCC classification to indicate overall survival. CCL17 represents a promising biomarker upon immune checkpoint blockade in mel... |
### Instruction:
Do survivin-specific CD4+ T cells are decreased in patients with survivin-positive myeloma?
### Response:
| We have, for the first time, quantified the circulating CD4+CD25- precursor frequency against survivin and demonstrated this is lower in myeloma patients than healthy donors. The number of survivin reactive CD4+CD25- T cells is inversely associated with tumor survivin expression suggesting suppression of survivin respo... |
### Instruction:
Is angiotensin-converting enzyme genotype a significant genetic risk factor for idiopathic nephrotic syndrome in Croatian children?
### Response:
| DD genotype is not a genetic risk factor for acquiring INS nor significant phenotype modifier regarding to clinical and pathohistological picture and response to steroids in Croatian children. The potential application of ACE genotyping in predicting cyclophosphamide response deserves further investigation. |
### Instruction:
Does cardiac β-Adrenoceptor Expression be Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses?
### Response:
| Cardiac β-AR are reduced over 6 weeks of sustained hyperglycemia in type-2 diabetic ZDF rats. This indicates cardiac [3H]CGP12177 retention and β1- and β2-AR expression are inversely correlated with the progression of type-2 diabetes. |
### Instruction:
Is the spread of multi drug resistant infections leading to an increase in the empirical antibiotic treatment failure in cirrhosis : a prospective survey?
### Response:
| Multi-resistant infections are increasing in hospitalized cirrhotic patients. A better knowledge of the epidemiological characteristics is important to improve the efficacy of empirical antibiotic therapy. The use of preventive measures aimed at reducing the spread of multi-resistant bacteria is also essential. |
### Instruction:
Does pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggest novel indications for existing cancer drugs?
### Response:
| Within several cancer types that are not ordinarily treated with platinum chemotherapy, we identified tumors with high levels of the three genomic biomarkers. These tumors represent identifiable subtypes of patients which may be strong candidates for clinical trials with PARP inhibitors or platinum-based chemotherapeut... |
### Instruction:
Does benefit finding predict depressive and anxious symptoms in women with breast cancer?
### Response:
| BFS-C is of good reliability and validity, and appropriate for assessing benefit finding in women with breast cancer. Worldview, family relationship, and acceptance are important contributing factors to depressive and anxious symptoms, which may be beneficial for women with breast cancer. |
### Instruction:
Does extracellular superoxide dismutase ameliorate streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling?
### Response:
| We conclude that rhEC-SOD can act as a therapeutic agent to protect the progression of diabetic nephropathy. |
### Instruction:
Does acute hepatitis C virus infection induce anti-host cell receptor antibodies with virus-neutralizing properties?
### Response:
| The virus-neutralizing properties of these Abs suggest a role for control of viral infection in conjunction with antiviral responses. Characterization of these anti-receptor Abs opens new avenues to prevent and treat HCV infection. |
### Instruction:
Is keratin 19 protein expression an independent predictor of survival in human hepatocellular carcinoma?
### Response:
| Our study confirms the prognostic significance of K19 expression in Caucasian patients with HCCs, providing further evidence that it may be used to stratify HCC according to tumour aggressiveness. |
### Instruction:
Is impaired antioxidant HDL function associated with premature myocardial infarction?
### Response:
| Impaired antioxidant function of HDL is independently associated with the development of premature AMI. The maintenance of HDL function might evolve into a significant therapeutic target, especially in patients with premature CAD. |
### Instruction:
Does discordant human epidermal growth factor receptor 2 overexpression in primary and metastatic upper gastrointestinal adenocarcinoma signify poor prognosis?
### Response:
| As trastuzumab is emerging as an important targeted therapy for patients with upper gastointestinal cancer, these results underline the importance of further studies addressing the occurrence and clinical significance of discrepant HER2 expression in primary tumours and metastases. |
### Instruction:
Does microRNA-188-5p suppress tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma?
### Response:
| These findings collectively demonstrate a tumor suppressor role of miR-188-5p in HCC progression via targeting FGF5, suggesting that miR-188-5p could serve as a potential prognostic biomarker and therapeutic target for HCC. |
### Instruction:
Are increased circulating macrophage migration inhibitory factor levels associated with coronary artery disease?
### Response:
| The circulating concentrations of migration inhibitory factor were significantly increased in acute myocardial infarction patients, whereas the soluble E-selectin levels were similar between acute myocardial infarction patients and control subjects. Our results suggest that migration inhibitory factor may play a role i... |
### Instruction:
Is local anesthesia with epinephrine safe and effective for oral surgery in patients with type 2 diabetes mellitus and coronary disease : a prospective randomized study?
### Response:
| The administration of 5.4 mL of 2% lidocaine with epinephrine neither caused hyperglycemia nor had any significant impact on hemodynamic or anxiety parameters. However, lower blood glucose levels were observed. This is the first report using continuous blood glucose monitoring to show the benefits and lack of side effe... |
### Instruction:
Does yi Qi Qing Re Gao formula ameliorate puromycin aminonucleoside-induced nephrosis by suppressing inflammation and apoptosis?
### Response:
| YQQRG alleviated kidney injury in PAN-treated rats, possibly through anti-inflammatory and anti-apoptotic effects. |
### Instruction:
Is benign Multiple Sclerosis Associated with Reduced Thinning of the Retinal Nerve Fiber and Ganglion Cell Layers in Non-Optic-Neuritis Eyes?
### Response:
| The RNFL and GCL were thinner in both ON- and non-ON MS, but the change was more pronounced in ON MS, irrespective of the MS subtype studied herein. GCL thinning and the thinning rate of both the GCL and RNFL were less pronounced in non-ON BMS than in non-ON RRMS. These findings may help to predict the course of BMS. |
### Instruction:
Are hPV16 CpG methyl-haplotypes associated with cervix precancer and cancer in the Guanacaste natural history study?
### Response:
| This study demonstrates that NGS of bisulfite treated HPV DNA is a useful and efficient technique to survey methylation patterns in HPV16. This procedure provides quantitative information on both individual CpG sites and methyl-haplotypes that identify women with elevated present or subsequent risk for HPV16 CIN3 and c... |
### Instruction:
Is stroke etiology associated with outcome in posterior circulation stroke?
### Response:
| The etiologies of PCS are heterogeneous and shown to be associated with functional outcomes. Our results have shed lights on future pathophysiological research and designs of clinical trials for PCS. |
### Instruction:
Does deficiency of ECHS1 cause mitochondrial encephalopathy with cardiac involvement?
### Response:
| In conclusion, we define the phenotypic spectrum of a new syndrome caused by ECHS1 deficiency. We speculate that both the β-oxidation defect and the block in l-valine metabolism, with accumulation of toxic methacrylyl-CoA and acryloyl-CoA, contribute to the disorder that may be amenable to metabolic treatment approache... |
### Instruction:
Does eGb761 ameliorate Neuropathic Pain by Scavenging Reactive Oxygen Species?
### Response:
| Taken together, our results suggest that administration of EGb761 can ameliorate neuropathic pain, and further indicate that JNK, which is activated by both exogenous and endogenous ROS, might be the mechanism underlying the effects of EGb761 on CCI neuropathic pain. |
### Instruction:
Are the FOXP1 , FOXP2 and FOXP4 transcription factors required for islet alpha cell proliferation and function in mice?
### Response:
| Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function. |
### Instruction:
Does brain correlate of the Interaction Between 5-HTTLPR and Psychosocial Stress Mediating Attention Deficit Hyperactivity Disorder Severity?
### Response:
| 5-HTTLPR genotype moderates the effect of stress on brain regions involved in social cognitive processing and cognitive control. Specifically, regions important for cognitive control link this gene-environment interaction to ADHD severity. |
### Instruction:
Is hLA-DPB1 variant rs3117242 associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese population?
### Response:
| The rs3117242 of HLA-DPB1 could be considered a genetic risk factor for GPA in Chinese Han people. These findings provide further insights and clues into the etiology of GPA and MPA. |
### Instruction:
Do in vitro fatigue and fracture resistance of one- and two-piece CAD/CAM zirconia implant abutments?
### Response:
| Superior resistance was achieved for two-piece hybrid CAD/CAM zirconia abutments. These abutments might be clinically beneficial in high-load areas, such as premolar and molar regions. |
### Instruction:
Are changes in fitness associated with changes in body composition and bone health in children after cancer?
### Response:
| Group-based exercise training did not improve aerobic fitness in children after cancer or bone marrow transplantation. However, changes in fitness throughout the study period were associated with changes in body composition and bone health in all participants. |
### Instruction:
Is female gender a social determinant of diabetes in the Caribbean : a systematic review and meta-analysis?
### Response:
| Female gender is a determinant of DM prevalence in the Caribbean. In the vast majority of world regions women are at a similar or lower risk of type 2 diabetes than men, even when obesity is higher in women. Caribbean female excess of diabetes may be due to a much greater excess of risk factors in women, especially obe... |
### Instruction:
Is plasma complement factor H associated with disease activity of patients with ANCA-associated vasculitis?
### Response:
| In conclusion, plasma CFH levels are associated with disease activity, and, to some extent, associated with composite outcomes of patients with MPO-ANCA-associated vasculitis. |
### Instruction:
Does [ Astragaloside IV regulate STAT1/IκB/NF-κB signaling pathway to inhibit activation of BV-2 cells ]?
### Response:
| ASI could restrain microglial activation through interfering STAT1/IκB/NF-κB signaling pathway, reducing gene expres- sion of IL-1β and TNF-α, and thus inhibiting the production of proinflammatory mediators such as NO and TNF-α. |
### Instruction:
Are molecular subtypes of urothelial carcinoma defined by specific gene regulatory systems?
### Response:
| At the gene regulatory level Urobasal, Genomically Unstable and SCC-like tumors represents three fundamentally different tumor types. Urobasal tumors maintain an apparent urothelial differentiation axis composed of PPARG/RXRA, FOXA1/GATA3 and anterior HOXA and HOXB genes. Genomically Unstable and SCC-like tumors differ... |
### Instruction:
Is myo-inositol a promising treatment for the prevention of ovarian hyperstimulation syndrome ( OHSS ) : an animal study?
### Response:
| Our data demonstrate that myo-inositol is effective in preventing OHSS, similar to metformin. Although the two drugs are thought to act through distinct mechanisms, there is no apparent benefit to co-treatment with both drugs in an animal model of OHSS. Administration of myo-inositol prior to IVF treatment may favor th... |
### Instruction:
Does abnormal cortical thickness connectivity persist in childhood absence epilepsy?
### Response:
| Brains in young adults whose CAE was resolved had abnormal structural connectivity. Our findings suggest that frontal regions correlate most with cortical thickness throughout the brain in CAE patients, whereas occipital regions correlate most in well matched normal controls. We interpret this as evidence of a developm... |
### Instruction:
Is paraxis required for somite morphogenesis and differentiation in Xenopus laevis?
### Response:
| Our results demonstrate that paraxis regulates the cell rearrangements that take place during the somitogenesis of Xenopus by regulating cell adhesion. Furthermore, paraxis is also required for somite differentiation. |
### Instruction:
Is habitual physical activity associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2?
### Response:
| This cross-sectional study has shown a weak association of irisin with physical activity levels in healthy controls but not in DMT2 subjects, suggesting the possibility of discordant regulation in the condition of DMT2. |
### Instruction:
Does self-Care Self-Efficacy correlate with Independence in Basic Activities of Daily Living in Individuals with Chronic Stroke?
### Response:
| Higher SCSE of individuals with chronic stroke contributes to more independence in BADL. Additional questionnaires regarding self efficacy for IADL should be developed and investigated. |
### Instruction:
Is evidence-based hamstring injury prevention adopted by the majority of Champions League or Norwegian Premier League football teams : the Nordic Hamstring survey?
### Response:
| Adoption and implementation of the NH exercise programme at the highest levels of male football in Europe is low; too low to expect any overall effect on acute hamstring injury rates. |
### Instruction:
Are obstructing ventral hernias independently associated with surgical site infections?
### Response:
| Obstruction in patients undergoing VHR is not independently associated with SSI. Our results suggest that mesh implantation remains a viable option in this setting. Other confounding comorbid conditions should be assessed at the time of surgical intervention to identify patients appropriate for mesh repair. |
### Instruction:
Does gastric Band Surgery lead to Improved Insulin Secretion in Overweight People with Type 2 Diabetes?
### Response:
| In overweight people with diabetes, LAGB improves endogenous beta-cell function after 2 years. Baseline beta-cell function correlated with diabetes remission, but not with HbA1c change following LAGB. |
### Instruction:
Are higher dietary anthocyanin and flavonol intakes associated with anti-inflammatory effects in a population of US adults?
### Response:
| These findings provide evidence to suggest that an anti-inflammatory effect may be a key component underlying the reduction in risk of certain chronic diseases associated with higher intakes of anthocyanins and flavonols. The Framingham Offspring Study was registered at clinicaltrials.gov as NCT00005121 (Framingham Hea... |
### Instruction:
Are fecal menaquinone profiles of overweight adults associated with gut microbiota composition during a gut microbiota-targeted dietary intervention?
### Response:
| These findings suggest that variability in fecal menaquinone content is predominantly determined by relatively few genera within the gut microbiota and that diet-mediated alterations in gut microbiota composition may provide a feasible approach for altering gut menaquinone content. This trial was registered at the Chin... |
### Instruction:
Is supplementation with a blend of krill and salmon oil associated with increased metabolic risk in overweight men?
### Response:
| Supplementation with a blend of KS oil is associated with decreased insulin sensitivity. Thus, krill-oil supplementation in overweight adults could exacerbate risk of diabetes and cardiovascular disease. This trial was prospectively registered at the Australian New Zealand Clinical Trials Registry as ACTRN1261100060292... |
### Instruction:
Does vancomycin modify the expression of the agr system in multidrug-resistant Staphylococcus aureus clinical isolates?
### Response:
| The polymorphism agrII, which is associated with nosocomial isolates, was the most prevalent polymorphism in MDR S. aureus. Additionally, under our study conditions, vancomycin modified hld and spa expression in these clinical isolates. Therefore, vancomycin may regulate alternative systems that jointly participate in ... |
### Instruction:
Do patient characteristics support unfavorable psychiatric outcome after treatment of unruptured intracranial aneurysms?
### Response:
| The current study demonstrates an increased rate of positive pre-interventional psychiatric histories in the iA collective. Although those patients represent only a small subgroup, they still may play an important role concerning the overall outcome after iA treatment. Early detection and psychological support in this ... |
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