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PMC2440383_F1_24739.jpg | What is being portrayed in this visual content? | Histology slide of myxoid liposarcoma showing lipoblasts and capillaries in a predominantly myxoid stroma (H&E stain, 10× magnifications). |
PMC2440384_F1_24740.jpg | What is the focal point of this photograph? | Maximum intensity projection (MIP) of the whole body FDG PET-CT imaging. There is intense uptake in the prostate tumor with invasion and infiltration to the bladder wall. Multiple FDG-avid metastatic lesions are noted in the liver, Lungs and lymph nodes of the mediastinum and retroperitoneum. |
PMC2440384_F2_24741.jpg | What is being portrayed in this visual content? | Neuroendocrine differentiation of the prostate cancer displays high grade of FDG uptake on transaxial PET-CT images, which is different from that noted in most of adenocarcinoma of the prostate. |
PMC2440384_F3_24743.jpg | What is the core subject represented in this visual? | FDG PET-CT images demonstrate multiple necrotic hepatic metastases while bone scan and CT two months earlier were negative. |
PMC2440384_F3_24744.jpg | What does this image primarily show? | FDG PET-CT images demonstrate multiple necrotic hepatic metastases while bone scan and CT two months earlier were negative. |
PMC2440384_F4_24745.jpg | What is being portrayed in this visual content? | FDG PET-CT images demonstrate a 1.3 cm aortocaval lymph node with intense uptake consistent with metastatic disease. |
PMC2440384_F4_24746.jpg | What is the dominant medical problem in this image? | FDG PET-CT images demonstrate a 1.3 cm aortocaval lymph node with intense uptake consistent with metastatic disease. |
PMC2440506_pone-0002584-g009_24760.jpg | Can you identify the primary element in this image? | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24749.jpg | What stands out most in this visual? | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24752.jpg | What key item or scene is captured in this photo? | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24751.jpg | What stands out most in this visual? | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24756.jpg | Describe the main subject of this image. | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24758.jpg | What object or scene is depicted here? | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24750.jpg | What object or scene is depicted here? | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440506_pone-0002584-g009_24759.jpg | Describe the main subject of this image. | High-Dose Simvastatin Reduces Stress Fiber Formation and Alters RMEC Polarisation during Migration.(A) Immunocytochemistry for F-actin in green using the FITC-phalloidin probe. Scale bars 100 µm. (B) Labelling of the Golgi apparatus on the leading edge of migrating RMECs by staning for Golgin 97 in green. Nuclei are st... |
PMC2440515_pone-0002539-g001_24763.jpg | What is the core subject represented in this visual? | Histopathological features of AIPC.(A) Overview of pancreatic parenchyma with typical AIPC changes. In the center, a duct (*) with periductal mononuclear infiltration and fibrosis. Interlobular fibrosis is shown (arrows). (B) Interlobular duct with moderate periductal mononuclear infiltration, fibrosis and beginning st... |
PMC2440515_pone-0002539-g001_24765.jpg | Can you identify the primary element in this image? | Histopathological features of AIPC.(A) Overview of pancreatic parenchyma with typical AIPC changes. In the center, a duct (*) with periductal mononuclear infiltration and fibrosis. Interlobular fibrosis is shown (arrows). (B) Interlobular duct with moderate periductal mononuclear infiltration, fibrosis and beginning st... |
PMC2440515_pone-0002539-g001_24764.jpg | What is the core subject represented in this visual? | Histopathological features of AIPC.(A) Overview of pancreatic parenchyma with typical AIPC changes. In the center, a duct (*) with periductal mononuclear infiltration and fibrosis. Interlobular fibrosis is shown (arrows). (B) Interlobular duct with moderate periductal mononuclear infiltration, fibrosis and beginning st... |
PMC2440515_pone-0002539-g001_24762.jpg | What is shown in this image? | Histopathological features of AIPC.(A) Overview of pancreatic parenchyma with typical AIPC changes. In the center, a duct (*) with periductal mononuclear infiltration and fibrosis. Interlobular fibrosis is shown (arrows). (B) Interlobular duct with moderate periductal mononuclear infiltration, fibrosis and beginning st... |
PMC2440515_pone-0002539-g001_24761.jpg | What does this image primarily show? | Histopathological features of AIPC.(A) Overview of pancreatic parenchyma with typical AIPC changes. In the center, a duct (*) with periductal mononuclear infiltration and fibrosis. Interlobular fibrosis is shown (arrows). (B) Interlobular duct with moderate periductal mononuclear infiltration, fibrosis and beginning st... |
PMC2440523_pone-0002582-g002_24775.jpg | What is the focal point of this photograph? | Actin tail phenotypes of R. raoultii and R. conorii in L929 cells.Following a 24 h infection, the bacteria were stained by indirect immunofluorescence using a polyclonal anti-SFG antibody followed by an anti-mouse-Alexa 594 Ig as a secondary antibody (red). F-actin was stained with FITC-phalloidin (green) and nucleic a... |
PMC2440523_pone-0002582-g002_24771.jpg | Can you identify the primary element in this image? | Actin tail phenotypes of R. raoultii and R. conorii in L929 cells.Following a 24 h infection, the bacteria were stained by indirect immunofluorescence using a polyclonal anti-SFG antibody followed by an anti-mouse-Alexa 594 Ig as a secondary antibody (red). F-actin was stained with FITC-phalloidin (green) and nucleic a... |
PMC2440523_pone-0002582-g002_24774.jpg | What is the principal component of this image? | Actin tail phenotypes of R. raoultii and R. conorii in L929 cells.Following a 24 h infection, the bacteria were stained by indirect immunofluorescence using a polyclonal anti-SFG antibody followed by an anti-mouse-Alexa 594 Ig as a secondary antibody (red). F-actin was stained with FITC-phalloidin (green) and nucleic a... |
PMC2440523_pone-0002582-g004_24770.jpg | What is the core subject represented in this visual? | Actin tail phenotype of R. raoultii in Vero cells.The same staining as that described in the Fig. 2 was applied on Vero cells infected for 24 h with R. raoultii (magnifications 40× and 100×). |
PMC2440523_pone-0002582-g006_24778.jpg | What can you see in this picture? | Plaque formation by R. raoultii and R. conorii in different cell lines.L929 or Vero cells monolayers were infected for 10 days with serial dilutions of bacteria, the pure inoculum being estimated by qRT-PCR as 2.5×107 rickettsiae per well. The “control” corresponds to non-infected cells. Upper panel: After crystal viol... |
PMC2440523_pone-0002582-g006_24776.jpg | What is the dominant medical problem in this image? | Plaque formation by R. raoultii and R. conorii in different cell lines.L929 or Vero cells monolayers were infected for 10 days with serial dilutions of bacteria, the pure inoculum being estimated by qRT-PCR as 2.5×107 rickettsiae per well. The “control” corresponds to non-infected cells. Upper panel: After crystal viol... |
PMC2440523_pone-0002582-g006_24781.jpg | What is being portrayed in this visual content? | Plaque formation by R. raoultii and R. conorii in different cell lines.L929 or Vero cells monolayers were infected for 10 days with serial dilutions of bacteria, the pure inoculum being estimated by qRT-PCR as 2.5×107 rickettsiae per well. The “control” corresponds to non-infected cells. Upper panel: After crystal viol... |
PMC2440523_pone-0002582-g006_24782.jpg | Describe the main subject of this image. | Plaque formation by R. raoultii and R. conorii in different cell lines.L929 or Vero cells monolayers were infected for 10 days with serial dilutions of bacteria, the pure inoculum being estimated by qRT-PCR as 2.5×107 rickettsiae per well. The “control” corresponds to non-infected cells. Upper panel: After crystal viol... |
PMC2440523_pone-0002582-g006_24777.jpg | What key item or scene is captured in this photo? | Plaque formation by R. raoultii and R. conorii in different cell lines.L929 or Vero cells monolayers were infected for 10 days with serial dilutions of bacteria, the pure inoculum being estimated by qRT-PCR as 2.5×107 rickettsiae per well. The “control” corresponds to non-infected cells. Upper panel: After crystal viol... |
PMC2440523_pone-0002582-g006_24779.jpg | What is the central feature of this picture? | Plaque formation by R. raoultii and R. conorii in different cell lines.L929 or Vero cells monolayers were infected for 10 days with serial dilutions of bacteria, the pure inoculum being estimated by qRT-PCR as 2.5×107 rickettsiae per well. The “control” corresponds to non-infected cells. Upper panel: After crystal viol... |
PMC2440549_F4_24783.jpg | What is shown in this image? | CD31 expression was assessed in tumors treated with various treatment regimens using immunohistochemistry. A – Control (untreated tumor), B – Short DLI 24 h, C – Long DLI 24 h, D – Short DLI 30 days, E – Long DLI 30 days. Control, short DLI 30 days and long DLI 30 days tumor sections exhibited 8 to 10% staining. In sho... |
PMC2440549_F4_24787.jpg | What is the main focus of this visual representation? | CD31 expression was assessed in tumors treated with various treatment regimens using immunohistochemistry. A – Control (untreated tumor), B – Short DLI 24 h, C – Long DLI 24 h, D – Short DLI 30 days, E – Long DLI 30 days. Control, short DLI 30 days and long DLI 30 days tumor sections exhibited 8 to 10% staining. In sho... |
PMC2440549_F4_24784.jpg | What is the dominant medical problem in this image? | CD31 expression was assessed in tumors treated with various treatment regimens using immunohistochemistry. A – Control (untreated tumor), B – Short DLI 24 h, C – Long DLI 24 h, D – Short DLI 30 days, E – Long DLI 30 days. Control, short DLI 30 days and long DLI 30 days tumor sections exhibited 8 to 10% staining. In sho... |
PMC2440549_F4_24786.jpg | Describe the main subject of this image. | CD31 expression was assessed in tumors treated with various treatment regimens using immunohistochemistry. A – Control (untreated tumor), B – Short DLI 24 h, C – Long DLI 24 h, D – Short DLI 30 days, E – Long DLI 30 days. Control, short DLI 30 days and long DLI 30 days tumor sections exhibited 8 to 10% staining. In sho... |
PMC2440551_fig07_24799.jpg | What key item or scene is captured in this photo? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24793.jpg | Describe the main subject of this image. | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24789.jpg | What is the main focus of this visual representation? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24790.jpg | What is the focal point of this photograph? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24792.jpg | What is shown in this image? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24797.jpg | What is the main focus of this visual representation? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24796.jpg | What object or scene is depicted here? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24798.jpg | Describe the main subject of this image. | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440551_fig07_24788.jpg | What is the core subject represented in this visual? | The first 48 amino acids of KdpD target GFP to the membrane. Localization of N48–GFP (A, D, G and J), KdpD–GFP (B, E, H and K), and N25–GFP (C, F, I and L) in wild-type E. coli strain MC1061. Synthesis of the GFP fusion proteins was induced either with IPTG for KdpD–GFP or arabinose for N25–GFP and N48–GFP. After induc... |
PMC2440740_F3_24801.jpg | What is the focal point of this photograph? | MRI artifact associated with the prototype Nitinol wire-reinforced atrial cannula used with the AB5000 Ventricle (gradient echo pulse sequence; TR/TE, 100-msec/15-msec; flip angle, 30 degrees; matrix size, 256 × 256; section thickness, 10-mm; field of view, 42-cm; long axis imaging plane). |
PMC2440740_F3_24800.jpg | What is the central feature of this picture? | MRI artifact associated with the prototype Nitinol wire-reinforced atrial cannula used with the AB5000 Ventricle (gradient echo pulse sequence; TR/TE, 100-msec/15-msec; flip angle, 30 degrees; matrix size, 256 × 256; section thickness, 10-mm; field of view, 42-cm; long axis imaging plane). |
PMC2440742_F4_24802.jpg | What is the principal component of this image? | YP2 protein contributes to yolk formation in the ovary of S. littoralis. (A) Western blot probed with YP2 antibody detected protein band at ~75 kDa in both seminal fluid (Lane 1) and ovarioles (Lane 2) of S. littoralis. Extracts of female fat body were immuno-negative (Lane 3). Equal amounts of total protein extracts (... |
PMC2440742_F4_24803.jpg | What is the core subject represented in this visual? | YP2 protein contributes to yolk formation in the ovary of S. littoralis. (A) Western blot probed with YP2 antibody detected protein band at ~75 kDa in both seminal fluid (Lane 1) and ovarioles (Lane 2) of S. littoralis. Extracts of female fat body were immuno-negative (Lane 3). Equal amounts of total protein extracts (... |
PMC2440751_F1_24805.jpg | What is the focal point of this photograph? | MRI and ultrasound images showing wire insertion. a) axial slice of a magnetic resonance scan at C4 level showing desired insertion path to the multifidus muscle and b) ultrasound image showing actual needle path and tip during insertion into the multifidus muscle. |
PMC2440751_F1_24806.jpg | What's the most prominent thing you notice in this picture? | MRI and ultrasound images showing wire insertion. a) axial slice of a magnetic resonance scan at C4 level showing desired insertion path to the multifidus muscle and b) ultrasound image showing actual needle path and tip during insertion into the multifidus muscle. |
PMC2440755_F1_24816.jpg | Describe the main subject of this image. | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440755_F1_24810.jpg | What can you see in this picture? | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440755_F1_24809.jpg | What object or scene is depicted here? | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440755_F1_24807.jpg | What is being portrayed in this visual content? | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440755_F1_24808.jpg | What key item or scene is captured in this photo? | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440755_F1_24811.jpg | Describe the main subject of this image. | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440755_F1_24815.jpg | What key item or scene is captured in this photo? | Formation of lattice cultures. A) DIC images of E17 cultures before and B) 1 DIV after Serum Free Medium (SFM) addition. C, D) Higher magnification (arrowhead in B and D identifies the same cell). D) Fiber-apposed cells have an elongated soma and a distinct leading process (arrow). E) Transmitted light time-lapse imagi... |
PMC2440756_F1_24820.jpg | What is shown in this image? | Two-dimensional echocardiogram, apical four-chamber view. (a) Pre-operative: a round echodense large mass attached to the calcified mitral annulus is seen. (b) Postoperative: a smaller round echodense mass attached to the calcified annulus is seen. |
PMC2440756_F1_24819.jpg | What is the main focus of this visual representation? | Two-dimensional echocardiogram, apical four-chamber view. (a) Pre-operative: a round echodense large mass attached to the calcified mitral annulus is seen. (b) Postoperative: a smaller round echodense mass attached to the calcified annulus is seen. |
PMC2440756_F2_24817.jpg | What object or scene is depicted here? | Two-dimensional echocardiogram, apical four-chamber view (detail). (a) Pre-operative: dyshomogeneous echodensity of the mass is evident. (b) Postoperative: the mass has central echolucency surrounded by a hyperechogenic region. |
PMC2440756_F2_24818.jpg | Describe the main subject of this image. | Two-dimensional echocardiogram, apical four-chamber view (detail). (a) Pre-operative: dyshomogeneous echodensity of the mass is evident. (b) Postoperative: the mass has central echolucency surrounded by a hyperechogenic region. |
PMC2440756_F3_24821.jpg | What is the core subject represented in this visual? | Two-dimensional echocardiogram, apical four-chamber view, colour Doppler. (a) Pre-operative: moderate to severe mitral regurgitation is present. (b) Postoperative: trivial mitral regurgitation is seen in the left atrium. |
PMC2440756_F3_24822.jpg | What does this image primarily show? | Two-dimensional echocardiogram, apical four-chamber view, colour Doppler. (a) Pre-operative: moderate to severe mitral regurgitation is present. (b) Postoperative: trivial mitral regurgitation is seen in the left atrium. |
PMC2440803_pone-0002622-g003_24823.jpg | What stands out most in this visual? | Some of the ES cell-derived neuronal colonies still contain at day 14 OCT3/4 and Ki67-positive cells.(A) After 14 days of differentiation culture few colonies (less than 5%), as exemplified here, still contain OCT3/4-positive cell clusters as detected by immunofluorescence staining using a specific mAb (magnification 4... |
PMC2440803_pone-0002622-g003_24824.jpg | What can you see in this picture? | Some of the ES cell-derived neuronal colonies still contain at day 14 OCT3/4 and Ki67-positive cells.(A) After 14 days of differentiation culture few colonies (less than 5%), as exemplified here, still contain OCT3/4-positive cell clusters as detected by immunofluorescence staining using a specific mAb (magnification 4... |
PMC2440803_pone-0002622-g003_24826.jpg | What is the principal component of this image? | Some of the ES cell-derived neuronal colonies still contain at day 14 OCT3/4 and Ki67-positive cells.(A) After 14 days of differentiation culture few colonies (less than 5%), as exemplified here, still contain OCT3/4-positive cell clusters as detected by immunofluorescence staining using a specific mAb (magnification 4... |
PMC2440803_pone-0002622-g003_24825.jpg | What key item or scene is captured in this photo? | Some of the ES cell-derived neuronal colonies still contain at day 14 OCT3/4 and Ki67-positive cells.(A) After 14 days of differentiation culture few colonies (less than 5%), as exemplified here, still contain OCT3/4-positive cell clusters as detected by immunofluorescence staining using a specific mAb (magnification 4... |
PMC2440805_pgen-1000123-g001_24827.jpg | What is shown in this image? | BY/RM hybrid progeny show altered sensitivity to the DNA damaging agent, 4-NQO.Phenotype testing of BY-RM hybrid segregants. Saturated cultures of BY, RM, rad52Δ (4-NQO control), and representative progeny of the BY×RM cross (segregants 47–54) were diluted in water and spotted in 10-fold serial dilution (undiluted to 1... |
PMC2440805_pgen-1000123-g004_24828.jpg | What does this image primarily show? | Phenotypic variation is seen in backcrossed 4-NQO-sensitive segregants mated to each other.Two 4-NQO-sensitive spore clones (3D-BK2-1, 3D-BK2-2) from the first backcross (3D-BK1×RM) were mated and the resulting progeny were tested for sensitivity to 4-NQO. The progeny are shown as Tetrads 1 and 2. Saturated cultures of... |
PMC2440805_pgen-1000123-g004_24830.jpg | What is being portrayed in this visual content? | Phenotypic variation is seen in backcrossed 4-NQO-sensitive segregants mated to each other.Two 4-NQO-sensitive spore clones (3D-BK2-1, 3D-BK2-2) from the first backcross (3D-BK1×RM) were mated and the resulting progeny were tested for sensitivity to 4-NQO. The progeny are shown as Tetrads 1 and 2. Saturated cultures of... |
PMC2440814_pone-0002598-g003_24831.jpg | What does this image primarily show? | Examples of hippocampal volumes from a high and low LEQ individual at the 3 year follow-up stage.Note the relative increase in the volume of the inferior horn of the lateral ventricle. Average volumes refer to the mean across right and left sides. Right hippocampus tracing shown in red. |
PMC2440814_pone-0002598-g003_24832.jpg | What does this image primarily show? | Examples of hippocampal volumes from a high and low LEQ individual at the 3 year follow-up stage.Note the relative increase in the volume of the inferior horn of the lateral ventricle. Average volumes refer to the mean across right and left sides. Right hippocampus tracing shown in red. |
PMC2440815_pone-0002635-g004_24834.jpg | What's the most prominent thing you notice in this picture? | fMRI results for MT+.(a) SPM of right MT+ (white arrow) in localizer experiment. (b) Speed and accuracy time courses for the coherence trials, time-locked and normalized to the onset of stimulus coherence. (c) Speed and accuracy time courses for the coherence trials, time-locked to the onset of the response (R) and nor... |
PMC2440815_pone-0002635-g004_24836.jpg | What is the dominant medical problem in this image? | fMRI results for MT+.(a) SPM of right MT+ (white arrow) in localizer experiment. (b) Speed and accuracy time courses for the coherence trials, time-locked and normalized to the onset of stimulus coherence. (c) Speed and accuracy time courses for the coherence trials, time-locked to the onset of the response (R) and nor... |
PMC2440815_pone-0002635-g004_24835.jpg | What is being portrayed in this visual content? | fMRI results for MT+.(a) SPM of right MT+ (white arrow) in localizer experiment. (b) Speed and accuracy time courses for the coherence trials, time-locked and normalized to the onset of stimulus coherence. (c) Speed and accuracy time courses for the coherence trials, time-locked to the onset of the response (R) and nor... |
PMC2440815_pone-0002635-g004_24833.jpg | What is the dominant medical problem in this image? | fMRI results for MT+.(a) SPM of right MT+ (white arrow) in localizer experiment. (b) Speed and accuracy time courses for the coherence trials, time-locked and normalized to the onset of stimulus coherence. (c) Speed and accuracy time courses for the coherence trials, time-locked to the onset of the response (R) and nor... |
PMC2440815_pone-0002635-g006_24837.jpg | What is shown in this image? | fMRI results for right primary motor cortex (M1).(a) Isolation of M1 (left) with the left-right manual response contrast of the event-related experiment. White arrow indicates Right M1. (b) Speed and accuracy time courses for the coherence trials, time-locked to the onset of the response (R) and normalized to the onset... |
PMC2440815_pone-0002635-g007_24841.jpg | What is the principal component of this image? | fMRI results for pLPFC (left column) and the average of left and right pre-SMA (right column): (a) Location of right pLPFC (white arrow) and pre-SMA (white arrow) in the localizer task.The anterior and posterior horizontal bars in the pre-SMA figure indicate the coronal planes of the anterior and posterior commissures.... |
PMC2440815_pone-0002635-g007_24842.jpg | Describe the main subject of this image. | fMRI results for pLPFC (left column) and the average of left and right pre-SMA (right column): (a) Location of right pLPFC (white arrow) and pre-SMA (white arrow) in the localizer task.The anterior and posterior horizontal bars in the pre-SMA figure indicate the coronal planes of the anterior and posterior commissures.... |
PMC2441435_pone-0002638-g002_24844.jpg | What is the dominant medical problem in this image? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24849.jpg | What stands out most in this visual? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24854.jpg | What can you see in this picture? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24855.jpg | What object or scene is depicted here? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24845.jpg | What is the focal point of this photograph? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24853.jpg | What can you see in this picture? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24846.jpg | What stands out most in this visual? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24850.jpg | What is the dominant medical problem in this image? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g002_24852.jpg | What stands out most in this visual? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.4-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.4-eGFP (tissue-specific reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E, I, M) Merge of bright field with fluor... |
PMC2441435_pone-0002638-g003_24865.jpg | What is the central feature of this picture? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.12-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.12-eGFP (silent reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E) Merge of bright field with fluorescence image... |
PMC2441435_pone-0002638-g003_24856.jpg | What is the principal component of this image? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.12-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.12-eGFP (silent reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E) Merge of bright field with fluorescence image... |
PMC2441435_pone-0002638-g003_24857.jpg | What key item or scene is captured in this photo? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.12-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.12-eGFP (silent reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E) Merge of bright field with fluorescence image... |
PMC2441435_pone-0002638-g003_24863.jpg | What object or scene is depicted here? | Comparison between eGFP fluorescence and eGFP expression patterns in Cer0.12-eGFP/CAGGS-RFP electroporated chick embryos.Chick embryos were co-electroporated with Cer0.12-eGFP (silent reporter) and pCAGGS-RFP (ubiquitous reporter) at stage HH3 and processed for WISH. (A, E) Merge of bright field with fluorescence image... |
PMC2441470_F6_24875.jpg | What is the principal component of this image? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24873.jpg | What object or scene is depicted here? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24877.jpg | What object or scene is depicted here? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24870.jpg | What object or scene is depicted here? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24874.jpg | What key item or scene is captured in this photo? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24879.jpg | What is shown in this image? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24878.jpg | What is the core subject represented in this visual? | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441470_F6_24868.jpg | Describe the main subject of this image. | Expression of selected renal marker genes in the adult mouse kidney. In situ hybridizations were performed on paraffin sections of adult kidneys taken from 12-week old mice. Whole transverse sections (upper panels) and magnifications (lower panels) are shown to illustrate marker gene expression in detail. (a) Slc5a2: p... |
PMC2441605_F1_24882.jpg | What's the most prominent thing you notice in this picture? | PET scan of patient N. 2, showing a focal hyperintensity signal at pancreatic head level; the magnetic resonance cholagiopancreatography (MRCP) showed the presence of a cystic dilatation of the whole Wirsung duct. Total pancreasectomy was performed, with a final diagnosis of in situ carcinoma within the cephalic Wirsun... |
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