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PMC2480967_fig1_25691.jpg | What key item or scene is captured in this photo? | Expression patterns of FGFR2 and FGF10 in normal pancreas and pancreatic cancer. The magnification is shown in the right bottom corner of each figure. (A and B) Immunostaining of FGFR2 (A) and FGF10 (B) in normal pancreas, showing that FGFR2 is expressed weakly in ductal cells (A, arrow) and acinar cells (A, arrow head... |
PMC2480967_fig1_25694.jpg | What can you see in this picture? | Expression patterns of FGFR2 and FGF10 in normal pancreas and pancreatic cancer. The magnification is shown in the right bottom corner of each figure. (A and B) Immunostaining of FGFR2 (A) and FGF10 (B) in normal pancreas, showing that FGFR2 is expressed weakly in ductal cells (A, arrow) and acinar cells (A, arrow head... |
PMC2480967_fig1_25697.jpg | What object or scene is depicted here? | Expression patterns of FGFR2 and FGF10 in normal pancreas and pancreatic cancer. The magnification is shown in the right bottom corner of each figure. (A and B) Immunostaining of FGFR2 (A) and FGF10 (B) in normal pancreas, showing that FGFR2 is expressed weakly in ductal cells (A, arrow) and acinar cells (A, arrow head... |
PMC2480981_fig1_25709.jpg | Describe the main subject of this image. | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25699.jpg | What object or scene is depicted here? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25707.jpg | What stands out most in this visual? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25710.jpg | What is the principal component of this image? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25703.jpg | What can you see in this picture? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25702.jpg | What is being portrayed in this visual content? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25698.jpg | What can you see in this picture? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25701.jpg | What is the principal component of this image? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25705.jpg | What key item or scene is captured in this photo? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25704.jpg | What is the core subject represented in this visual? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2480981_fig1_25700.jpg | What is the focal point of this photograph? | Caveolin-1 and CAV2 expression in invasive duct carcinoma (IDC) of the breast. (A–C) CAV1 expression in Grade 3 IDC. (D–F) CAV1 positive expression in Grade1 IDC the arrow in (E) point to the associated DCIS component. (G–I) CAV1 negative expression in Grade 1 IDC. (J–L) CAV2 positive expression in Grade3 IDC. (M–O) CA... |
PMC2481245_F1_25713.jpg | What is the dominant medical problem in this image? | Image acquisition of velocity encoded (VENC) cine cardiovascular magnetic resonance imaging (CMR) at the level of mitral valve (MV). A) Cine 4 chamber image demonstrating the prescription of slice at the level of the tips of the MV leaflets. B) VENC CMR short axis image at the level of MV leaflet tips. Contour is drawn... |
PMC2481245_F1_25717.jpg | What can you see in this picture? | Image acquisition of velocity encoded (VENC) cine cardiovascular magnetic resonance imaging (CMR) at the level of mitral valve (MV). A) Cine 4 chamber image demonstrating the prescription of slice at the level of the tips of the MV leaflets. B) VENC CMR short axis image at the level of MV leaflet tips. Contour is drawn... |
PMC2481245_F1_25715.jpg | What's the most prominent thing you notice in this picture? | Image acquisition of velocity encoded (VENC) cine cardiovascular magnetic resonance imaging (CMR) at the level of mitral valve (MV). A) Cine 4 chamber image demonstrating the prescription of slice at the level of the tips of the MV leaflets. B) VENC CMR short axis image at the level of MV leaflet tips. Contour is drawn... |
PMC2481245_F1_25714.jpg | What is being portrayed in this visual content? | Image acquisition of velocity encoded (VENC) cine cardiovascular magnetic resonance imaging (CMR) at the level of mitral valve (MV). A) Cine 4 chamber image demonstrating the prescription of slice at the level of the tips of the MV leaflets. B) VENC CMR short axis image at the level of MV leaflet tips. Contour is drawn... |
PMC2481259_F1_25725.jpg | What is the main focus of this visual representation? | Immunofluorescence and Immuno-electron microscope labelling of the T. brucei TAC. A-F. Immunofluorescence on wild-type cytoskeletons. A. DAPI staining (blue) and Mab 22 labelling (green). B. A merged phase contrast, DAPI staining and Mab 22 labelling of the cytoskeleton in A. The arrows in A and B show the Mab 22 flage... |
PMC2481259_F1_25721.jpg | Can you identify the primary element in this image? | Immunofluorescence and Immuno-electron microscope labelling of the T. brucei TAC. A-F. Immunofluorescence on wild-type cytoskeletons. A. DAPI staining (blue) and Mab 22 labelling (green). B. A merged phase contrast, DAPI staining and Mab 22 labelling of the cytoskeleton in A. The arrows in A and B show the Mab 22 flage... |
PMC2481259_F1_25724.jpg | What can you see in this picture? | Immunofluorescence and Immuno-electron microscope labelling of the T. brucei TAC. A-F. Immunofluorescence on wild-type cytoskeletons. A. DAPI staining (blue) and Mab 22 labelling (green). B. A merged phase contrast, DAPI staining and Mab 22 labelling of the cytoskeleton in A. The arrows in A and B show the Mab 22 flage... |
PMC2481259_F1_25718.jpg | What is being portrayed in this visual content? | Immunofluorescence and Immuno-electron microscope labelling of the T. brucei TAC. A-F. Immunofluorescence on wild-type cytoskeletons. A. DAPI staining (blue) and Mab 22 labelling (green). B. A merged phase contrast, DAPI staining and Mab 22 labelling of the cytoskeleton in A. The arrows in A and B show the Mab 22 flage... |
PMC2481259_F1_25722.jpg | What is the central feature of this picture? | Immunofluorescence and Immuno-electron microscope labelling of the T. brucei TAC. A-F. Immunofluorescence on wild-type cytoskeletons. A. DAPI staining (blue) and Mab 22 labelling (green). B. A merged phase contrast, DAPI staining and Mab 22 labelling of the cytoskeleton in A. The arrows in A and B show the Mab 22 flage... |
PMC2481264_F1_25728.jpg | What is the focal point of this photograph? | CT scans. (a) Liver metastasis (long arrow). (b) Response with reduction in the size of the liver metastasis (long arrow). (c) Development of varices at the lower oesophagus (long arrow). (d) Splenomegaly (long arrow) and ascites (short arrow). |
PMC2481264_F1_25730.jpg | Describe the main subject of this image. | CT scans. (a) Liver metastasis (long arrow). (b) Response with reduction in the size of the liver metastasis (long arrow). (c) Development of varices at the lower oesophagus (long arrow). (d) Splenomegaly (long arrow) and ascites (short arrow). |
PMC2481265_F4_25731.jpg | What is the main focus of this visual representation? | Neoplasm composed of diffuse oncocytic cells. The tumor was composed of polygonal oncocytes with granular, eosinophilic cytoplasm. Hematoxylin and eosin, magnification ×200. |
PMC2481274_pone-0002737-g009_25732.jpg | What key item or scene is captured in this photo? | Immunohistochemical analyses of biopsies from psoriatic lesional and nonlesional skin and skin from normal donors.BDCA2 is a specific marker for pDCs, which are present at greater numbers in lesional skin (inset is 100×) compared with nonlesional skin, and not at all in skin from healthy donors. CD83 is a marker for mD... |
PMC2481275_pone-0002540-g004_25736.jpg | What is being portrayed in this visual content? | Effects of Aging on the Trabecular Bone Texture in the Proximal Tibial Metaphysis.Due to aging, the proportion of trabecular bone of the bone volume (TV/BV) is decreased in males and females. In addition, in males, the number (Tb.N.) and thickness (Tb.Th.) of the trabeculae is decreased, while the distance between indi... |
PMC2481275_pone-0002540-g004_25733.jpg | Can you identify the primary element in this image? | Effects of Aging on the Trabecular Bone Texture in the Proximal Tibial Metaphysis.Due to aging, the proportion of trabecular bone of the bone volume (TV/BV) is decreased in males and females. In addition, in males, the number (Tb.N.) and thickness (Tb.Th.) of the trabeculae is decreased, while the distance between indi... |
PMC2481275_pone-0002540-g004_25735.jpg | What is the principal component of this image? | Effects of Aging on the Trabecular Bone Texture in the Proximal Tibial Metaphysis.Due to aging, the proportion of trabecular bone of the bone volume (TV/BV) is decreased in males and females. In addition, in males, the number (Tb.N.) and thickness (Tb.Th.) of the trabeculae is decreased, while the distance between indi... |
PMC2481287_pone-0002655-g005_25737.jpg | What is being portrayed in this visual content? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25744.jpg | Can you identify the primary element in this image? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25742.jpg | What's the most prominent thing you notice in this picture? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25745.jpg | What object or scene is depicted here? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25739.jpg | What stands out most in this visual? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25743.jpg | What is shown in this image? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25740.jpg | What is the principal component of this image? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25738.jpg | What can you see in this picture? | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481287_pone-0002655-g005_25741.jpg | Describe the main subject of this image. | Growth comparison of the wild type strain B-5233 with the strains JSA1 and JSB1.JSA1 and JSB1 are mutant strains with deletion of the genes farA and farB, respectively. Conidia from B-5233 (A, D, G), JSA1 (B, E, H) and JSB1 (C, F, I) were inoculated in media supplemented with glucose (A–C), fatty acid mixture FA (D–F) ... |
PMC2481290_pone-0002689-g004_25756.jpg | Can you identify the primary element in this image? | Gastric biopsy of a rhesus monkey with H. pylori and H. heilmannii co-infection.Genta stain (A: 400X; insert: 1,000X) demonstrates the presence of high H. heilmannii infection (typical tightly spiraled, ∼10 µm-long rods), in addition to a few H. pylori–like bacteria (∼3 µm-long and curved). In situ hybridization (ISH) ... |
PMC2481290_pone-0002689-g004_25754.jpg | What is shown in this image? | Gastric biopsy of a rhesus monkey with H. pylori and H. heilmannii co-infection.Genta stain (A: 400X; insert: 1,000X) demonstrates the presence of high H. heilmannii infection (typical tightly spiraled, ∼10 µm-long rods), in addition to a few H. pylori–like bacteria (∼3 µm-long and curved). In situ hybridization (ISH) ... |
PMC2481291_pone-0002634-g002_25750.jpg | What's the most prominent thing you notice in this picture? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25752.jpg | What stands out most in this visual? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25753.jpg | What stands out most in this visual? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25751.jpg | What is the central feature of this picture? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25747.jpg | What is the principal component of this image? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25746.jpg | What key item or scene is captured in this photo? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25749.jpg | Describe the main subject of this image. | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481291_pone-0002634-g002_25748.jpg | What is the central feature of this picture? | Phenotype of mouse MPCs infected with EWS-FLI-1, EWS-FLI-1 R340N mutant, EWS-ERG, FUS-ERG ESFT, FUS-ERG AML, ERG-1, FLI-1 or an empty pMSCV puro vector.Images were taken 3 days after infection (200X magnification). |
PMC2481302_pone-0002657-g001_25757.jpg | What is the main focus of this visual representation? | Immobilized CXCL4 or CXCL4/CTF promotes human umbilical vein endothelial cells (HUVECs) spreading, focal adhesion and stress fiber formation.(A) Analysis of spreading, focal adhesion and stress fibers. HUVECs were plated for 4h on coverslips that had been coated with (25 µg/ml) CXCL4, (25 µg/ml) CXCL4/CTF, (100 µg/ml) ... |
PMC2481302_pone-0002657-g001_25763.jpg | What's the most prominent thing you notice in this picture? | Immobilized CXCL4 or CXCL4/CTF promotes human umbilical vein endothelial cells (HUVECs) spreading, focal adhesion and stress fiber formation.(A) Analysis of spreading, focal adhesion and stress fibers. HUVECs were plated for 4h on coverslips that had been coated with (25 µg/ml) CXCL4, (25 µg/ml) CXCL4/CTF, (100 µg/ml) ... |
PMC2481302_pone-0002657-g001_25761.jpg | What is the main focus of this visual representation? | Immobilized CXCL4 or CXCL4/CTF promotes human umbilical vein endothelial cells (HUVECs) spreading, focal adhesion and stress fiber formation.(A) Analysis of spreading, focal adhesion and stress fibers. HUVECs were plated for 4h on coverslips that had been coated with (25 µg/ml) CXCL4, (25 µg/ml) CXCL4/CTF, (100 µg/ml) ... |
PMC2481302_pone-0002657-g001_25762.jpg | What object or scene is depicted here? | Immobilized CXCL4 or CXCL4/CTF promotes human umbilical vein endothelial cells (HUVECs) spreading, focal adhesion and stress fiber formation.(A) Analysis of spreading, focal adhesion and stress fibers. HUVECs were plated for 4h on coverslips that had been coated with (25 µg/ml) CXCL4, (25 µg/ml) CXCL4/CTF, (100 µg/ml) ... |
PMC2481450_F1_25767.jpg | What is the focal point of this photograph? | Imaging findings of a brain-injured adult. (a) Brain computed tomography (CT) scan of a patient showing a midline shift of more than 5 mm and a nonevacuated lesion of more than 25 ml. (b) Transorbital sonography of the same patient documenting increased optic nerve sheath diameter. |
PMC2481490_F1_25771.jpg | What is the dominant medical problem in this image? | Changes in mammary gland architecture induced by estrogen and progesterone. Tissues from mice that were nulliparous (a, d), E+P-treated (b, e), and parous (c, f) were examined using whole mounts (a-c) and 4-μm sections stained with hematoxylin and eosin (d-f). Magnifications, × 4 (a-c) and × 100 (d-f). E+P, estrogen an... |
PMC2481490_F1_25772.jpg | What is the core subject represented in this visual? | Changes in mammary gland architecture induced by estrogen and progesterone. Tissues from mice that were nulliparous (a, d), E+P-treated (b, e), and parous (c, f) were examined using whole mounts (a-c) and 4-μm sections stained with hematoxylin and eosin (d-f). Magnifications, × 4 (a-c) and × 100 (d-f). E+P, estrogen an... |
PMC2481490_F1_25769.jpg | What is the dominant medical problem in this image? | Changes in mammary gland architecture induced by estrogen and progesterone. Tissues from mice that were nulliparous (a, d), E+P-treated (b, e), and parous (c, f) were examined using whole mounts (a-c) and 4-μm sections stained with hematoxylin and eosin (d-f). Magnifications, × 4 (a-c) and × 100 (d-f). E+P, estrogen an... |
PMC2481490_F1_25768.jpg | Describe the main subject of this image. | Changes in mammary gland architecture induced by estrogen and progesterone. Tissues from mice that were nulliparous (a, d), E+P-treated (b, e), and parous (c, f) were examined using whole mounts (a-c) and 4-μm sections stained with hematoxylin and eosin (d-f). Magnifications, × 4 (a-c) and × 100 (d-f). E+P, estrogen an... |
PMC2481490_F1_25773.jpg | What stands out most in this visual? | Changes in mammary gland architecture induced by estrogen and progesterone. Tissues from mice that were nulliparous (a, d), E+P-treated (b, e), and parous (c, f) were examined using whole mounts (a-c) and 4-μm sections stained with hematoxylin and eosin (d-f). Magnifications, × 4 (a-c) and × 100 (d-f). E+P, estrogen an... |
PMC2481490_F1_25770.jpg | What is the focal point of this photograph? | Changes in mammary gland architecture induced by estrogen and progesterone. Tissues from mice that were nulliparous (a, d), E+P-treated (b, e), and parous (c, f) were examined using whole mounts (a-c) and 4-μm sections stained with hematoxylin and eosin (d-f). Magnifications, × 4 (a-c) and × 100 (d-f). E+P, estrogen an... |
PMC2481503_F1_25775.jpg | What object or scene is depicted here? | Immunohistochemical double-staining of human breast tumors for CD44 and CD24. CD44 is stained with Permanent Red and CD24 with diaminobenzidene (DAB). Magnification × 20. (a) A tumor positive for both CD44+/CD24- (white arrow) and CD44-/CD24+ (black arrow) cancer cells, although the predominant phenotype is CD44-/CD24-... |
PMC2481503_F1_25774.jpg | What is the principal component of this image? | Immunohistochemical double-staining of human breast tumors for CD44 and CD24. CD44 is stained with Permanent Red and CD24 with diaminobenzidene (DAB). Magnification × 20. (a) A tumor positive for both CD44+/CD24- (white arrow) and CD44-/CD24+ (black arrow) cancer cells, although the predominant phenotype is CD44-/CD24-... |
PMC2481503_F1_25776.jpg | What is the dominant medical problem in this image? | Immunohistochemical double-staining of human breast tumors for CD44 and CD24. CD44 is stained with Permanent Red and CD24 with diaminobenzidene (DAB). Magnification × 20. (a) A tumor positive for both CD44+/CD24- (white arrow) and CD44-/CD24+ (black arrow) cancer cells, although the predominant phenotype is CD44-/CD24-... |
PMC2481503_F1_25777.jpg | What stands out most in this visual? | Immunohistochemical double-staining of human breast tumors for CD44 and CD24. CD44 is stained with Permanent Red and CD24 with diaminobenzidene (DAB). Magnification × 20. (a) A tumor positive for both CD44+/CD24- (white arrow) and CD44-/CD24+ (black arrow) cancer cells, although the predominant phenotype is CD44-/CD24-... |
PMC2481504_F3_25793.jpg | What stands out most in this visual? | Three-dimensional culture of single cells from normal prelactating mammary gland, MINO precancer, and invasive carcinoma. (a, d, g) Inverted microscope phase contrast images as well as histologic images generated from paraffin-embedded 4 μm sections of the three-dimensional cultures stained by immunohistochemistry with... |
PMC2481504_F3_25796.jpg | What can you see in this picture? | Three-dimensional culture of single cells from normal prelactating mammary gland, MINO precancer, and invasive carcinoma. (a, d, g) Inverted microscope phase contrast images as well as histologic images generated from paraffin-embedded 4 μm sections of the three-dimensional cultures stained by immunohistochemistry with... |
PMC2481504_F3_25791.jpg | Can you identify the primary element in this image? | Three-dimensional culture of single cells from normal prelactating mammary gland, MINO precancer, and invasive carcinoma. (a, d, g) Inverted microscope phase contrast images as well as histologic images generated from paraffin-embedded 4 μm sections of the three-dimensional cultures stained by immunohistochemistry with... |
PMC2481504_F3_25792.jpg | What object or scene is depicted here? | Three-dimensional culture of single cells from normal prelactating mammary gland, MINO precancer, and invasive carcinoma. (a, d, g) Inverted microscope phase contrast images as well as histologic images generated from paraffin-embedded 4 μm sections of the three-dimensional cultures stained by immunohistochemistry with... |
PMC2481504_F3_25788.jpg | What object or scene is depicted here? | Three-dimensional culture of single cells from normal prelactating mammary gland, MINO precancer, and invasive carcinoma. (a, d, g) Inverted microscope phase contrast images as well as histologic images generated from paraffin-embedded 4 μm sections of the three-dimensional cultures stained by immunohistochemistry with... |
PMC2481504_F3_25795.jpg | What is the main focus of this visual representation? | Three-dimensional culture of single cells from normal prelactating mammary gland, MINO precancer, and invasive carcinoma. (a, d, g) Inverted microscope phase contrast images as well as histologic images generated from paraffin-embedded 4 μm sections of the three-dimensional cultures stained by immunohistochemistry with... |
PMC2481504_F4_25780.jpg | What key item or scene is captured in this photo? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25778.jpg | What is the main focus of this visual representation? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25786.jpg | What is being portrayed in this visual content? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25784.jpg | What key item or scene is captured in this photo? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25782.jpg | What is the principal component of this image? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25783.jpg | What is being portrayed in this visual content? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25785.jpg | What is the dominant medical problem in this image? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2481504_F4_25781.jpg | What is being portrayed in this visual content? | Immunohistochemistry profile of MINOsphere-derived outgrowth versus the original MINO tissue outgrowth. The outgrowth derived from a MINOsphere transplant (a, c, e, g, i, k) shows analogous expression compared with the MINO tissue outgrowth from the donor (b, d, f, h, j, m) for the following: luminal epithelial, CK8–18... |
PMC2483249_pone-0002850-g004_25803.jpg | What object or scene is depicted here? | Disruption of zebrafish K-ras signaling resulted in the defective angiogenesis.(A) Both un-injected and k-ras-MO injected fli1-GFP embryos (22 hpf) showed normal development of dorsal aorta and caudal artery (indicted by solid arrows), posterior cardinal vein and caudal vein (indicated by empty arrows). Higher magnific... |
PMC2483249_pone-0002850-g004_25804.jpg | What is being portrayed in this visual content? | Disruption of zebrafish K-ras signaling resulted in the defective angiogenesis.(A) Both un-injected and k-ras-MO injected fli1-GFP embryos (22 hpf) showed normal development of dorsal aorta and caudal artery (indicted by solid arrows), posterior cardinal vein and caudal vein (indicated by empty arrows). Higher magnific... |
PMC2483249_pone-0002850-g004_25798.jpg | What is the principal component of this image? | Disruption of zebrafish K-ras signaling resulted in the defective angiogenesis.(A) Both un-injected and k-ras-MO injected fli1-GFP embryos (22 hpf) showed normal development of dorsal aorta and caudal artery (indicted by solid arrows), posterior cardinal vein and caudal vein (indicated by empty arrows). Higher magnific... |
PMC2483257_F3_25811.jpg | What does this image primarily show? | Ultrastructural appearance of infected macrophages following exposure to ATP. A. Electron micrograph of a non-ATP treated, BCG-infected macrophage showing the presence of the bacteria within phagosomes (BP). B. Exposure to ATP is associated with the appearance of numerous double-membrane autophagic vacuoles (AV) within... |
PMC2483257_F3_25810.jpg | What's the most prominent thing you notice in this picture? | Ultrastructural appearance of infected macrophages following exposure to ATP. A. Electron micrograph of a non-ATP treated, BCG-infected macrophage showing the presence of the bacteria within phagosomes (BP). B. Exposure to ATP is associated with the appearance of numerous double-membrane autophagic vacuoles (AV) within... |
PMC2483258_F1_25815.jpg | Describe the main subject of this image. | LTB4-loaded MS provoke leukocyte infiltration in the lung parenchyma. The lungs were removed on day 7 after the administrations, fixed and paraffin-embedded, followed by staining with HE. Lung sections are representative of three experiments with 5-LO-/- mice (5 animals each group) that received (A) PBS; (B) LTB4 in so... |
PMC2483258_F1_25812.jpg | What's the most prominent thing you notice in this picture? | LTB4-loaded MS provoke leukocyte infiltration in the lung parenchyma. The lungs were removed on day 7 after the administrations, fixed and paraffin-embedded, followed by staining with HE. Lung sections are representative of three experiments with 5-LO-/- mice (5 animals each group) that received (A) PBS; (B) LTB4 in so... |
PMC2483258_F1_25814.jpg | Can you identify the primary element in this image? | LTB4-loaded MS provoke leukocyte infiltration in the lung parenchyma. The lungs were removed on day 7 after the administrations, fixed and paraffin-embedded, followed by staining with HE. Lung sections are representative of three experiments with 5-LO-/- mice (5 animals each group) that received (A) PBS; (B) LTB4 in so... |
PMC2483258_F1_25813.jpg | Can you identify the primary element in this image? | LTB4-loaded MS provoke leukocyte infiltration in the lung parenchyma. The lungs were removed on day 7 after the administrations, fixed and paraffin-embedded, followed by staining with HE. Lung sections are representative of three experiments with 5-LO-/- mice (5 animals each group) that received (A) PBS; (B) LTB4 in so... |
PMC2483262_F2_25816.jpg | What's the most prominent thing you notice in this picture? | Contrast enhanced CT scan (coronal view) showing an oval lobulated iso-dense mass measuring about 7.0 × 5.0 cm confined to the nasal vault and the ethmoids. |
PMC2483278_F2_25817.jpg | What is the main focus of this visual representation? | Lateral X ray of Thoracic spine. |
PMC2483279_F2_25825.jpg | What is the dominant medical problem in this image? | Seminiferous tubules of testis from C57BL/6J wild type mice after in vivo transfection with the pEGFP-N1 vector. A and C) Merge image of partial view of tubule sections showing EGFP-positive Sertoli cells (with the well-known arborescent-like cytoplasm) as preferentially transfected cells. Nuclei were stained with Hoec... |
PMC2483279_F2_25826.jpg | What can you see in this picture? | Seminiferous tubules of testis from C57BL/6J wild type mice after in vivo transfection with the pEGFP-N1 vector. A and C) Merge image of partial view of tubule sections showing EGFP-positive Sertoli cells (with the well-known arborescent-like cytoplasm) as preferentially transfected cells. Nuclei were stained with Hoec... |
PMC2483279_F4_25824.jpg | What is the main focus of this visual representation? | Primary culture of Sertoli cells from EGFP transgenic mice (FM131) transfected with pGtoR. The analysis was performed at 120 h (A, B and C) and 140 h (D, E and F) after transfection. Green fluorescence (excitation wavelength 488 nm) (A and D). Red fluorescence (B and E). Merge (C and F). Transfected cells (as demonstra... |
PMC2483279_F4_25819.jpg | What is the dominant medical problem in this image? | Primary culture of Sertoli cells from EGFP transgenic mice (FM131) transfected with pGtoR. The analysis was performed at 120 h (A, B and C) and 140 h (D, E and F) after transfection. Green fluorescence (excitation wavelength 488 nm) (A and D). Red fluorescence (B and E). Merge (C and F). Transfected cells (as demonstra... |
PMC2483279_F4_25821.jpg | What is the dominant medical problem in this image? | Primary culture of Sertoli cells from EGFP transgenic mice (FM131) transfected with pGtoR. The analysis was performed at 120 h (A, B and C) and 140 h (D, E and F) after transfection. Green fluorescence (excitation wavelength 488 nm) (A and D). Red fluorescence (B and E). Merge (C and F). Transfected cells (as demonstra... |
PMC2483279_F4_25822.jpg | What is being portrayed in this visual content? | Primary culture of Sertoli cells from EGFP transgenic mice (FM131) transfected with pGtoR. The analysis was performed at 120 h (A, B and C) and 140 h (D, E and F) after transfection. Green fluorescence (excitation wavelength 488 nm) (A and D). Red fluorescence (B and E). Merge (C and F). Transfected cells (as demonstra... |
PMC2483279_F4_25820.jpg | What object or scene is depicted here? | Primary culture of Sertoli cells from EGFP transgenic mice (FM131) transfected with pGtoR. The analysis was performed at 120 h (A, B and C) and 140 h (D, E and F) after transfection. Green fluorescence (excitation wavelength 488 nm) (A and D). Red fluorescence (B and E). Merge (C and F). Transfected cells (as demonstra... |
PMC2483284_F6_25831.jpg | What's the most prominent thing you notice in this picture? | Histological examinations of gastric remains of a Mexican mummy with hematoxin-eosin stain. A) 4×; B) 10×; C) 40×, and D) 100×. |
PMC2483284_F6_25829.jpg | What key item or scene is captured in this photo? | Histological examinations of gastric remains of a Mexican mummy with hematoxin-eosin stain. A) 4×; B) 10×; C) 40×, and D) 100×. |
PMC2483284_F6_25832.jpg | What is the core subject represented in this visual? | Histological examinations of gastric remains of a Mexican mummy with hematoxin-eosin stain. A) 4×; B) 10×; C) 40×, and D) 100×. |
PMC2483284_F6_25830.jpg | What is the dominant medical problem in this image? | Histological examinations of gastric remains of a Mexican mummy with hematoxin-eosin stain. A) 4×; B) 10×; C) 40×, and D) 100×. |
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