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PMC1950713_F5_13234.jpg | What is being portrayed in this visual content? | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950713_F5_13230.jpg | What does this image primarily show? | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950713_F5_13233.jpg | Can you identify the primary element in this image? | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950713_F5_13232.jpg | What is being portrayed in this visual content? | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950713_F5_13236.jpg | Describe the main subject of this image. | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950713_F5_13228.jpg | What is the main focus of this visual representation? | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950713_F5_13238.jpg | What is being portrayed in this visual content? | Effect of HIF2α on tumour necrosis and late proliferation. a) Macroscopic observations of tumour nodules and b) histological analyses of Masson's trichrome stained sections reveal extended necrotic areas within day 28-HIF2α(1–485) expressing neuroblastomas, compared to control tumours. Such defects are less often obser... |
PMC1950864_F1_13242.jpg | What is the principal component of this image? | Activated pDCs in JDM muscle. JDM muscle samples were stained for CD123 (green fluorescent avidin), CD83 (Texas Red), and the nucleus (DAPI). Most of the pDCs in the JDM muscle were activated (CD123+ CD83+, yellow in overlay). Magnification: × 40. |
PMC1950864_F1_13243.jpg | What object or scene is depicted here? | Activated pDCs in JDM muscle. JDM muscle samples were stained for CD123 (green fluorescent avidin), CD83 (Texas Red), and the nucleus (DAPI). Most of the pDCs in the JDM muscle were activated (CD123+ CD83+, yellow in overlay). Magnification: × 40. |
PMC1950864_F1_13241.jpg | What stands out most in this visual? | Activated pDCs in JDM muscle. JDM muscle samples were stained for CD123 (green fluorescent avidin), CD83 (Texas Red), and the nucleus (DAPI). Most of the pDCs in the JDM muscle were activated (CD123+ CD83+, yellow in overlay). Magnification: × 40. |
PMC1950864_F2_13239.jpg | What is the core subject represented in this visual? | Architecture and cellular composition of inflammatory infiltrates in JDM muscle. pDCs (arrow heads denote pDC aggregates) were localized in close proximity to B-cells (arrows denote CD20+ B cells) and T-cells (not shown). Magnification: × 40 |
PMC1950869_F1_13245.jpg | What object or scene is depicted here? | Tyrosine Hydroxylase (TH) immunoreactivity in transverse sections of sciatic nerve (proximal to SNI injury). Representative microphotography of TH-IR in vehicle treated control animals (right panels), while the signal was abolished in animals injected postnatally with guanethidine (sympathectomized group, left panels). |
PMC1950869_F1_13247.jpg | What is the main focus of this visual representation? | Tyrosine Hydroxylase (TH) immunoreactivity in transverse sections of sciatic nerve (proximal to SNI injury). Representative microphotography of TH-IR in vehicle treated control animals (right panels), while the signal was abolished in animals injected postnatally with guanethidine (sympathectomized group, left panels). |
PMC1950869_F1_13244.jpg | What key item or scene is captured in this photo? | Tyrosine Hydroxylase (TH) immunoreactivity in transverse sections of sciatic nerve (proximal to SNI injury). Representative microphotography of TH-IR in vehicle treated control animals (right panels), while the signal was abolished in animals injected postnatally with guanethidine (sympathectomized group, left panels). |
PMC1950869_F5_13252.jpg | What is being portrayed in this visual content? | TH-IR and pericellular baskets in injured and non-injured DRG neurons. A to D Representative photomicrograph of double fluorescent immunohistochemistry for ATF3 (green) and TH (red) in L4 DRG 8 weeks after SNI. A and B, TH-IR fibers surround both non-injured (arrow), and injured cells (arrowhead, ATF3 positive). Not al... |
PMC1950869_F5_13248.jpg | Can you identify the primary element in this image? | TH-IR and pericellular baskets in injured and non-injured DRG neurons. A to D Representative photomicrograph of double fluorescent immunohistochemistry for ATF3 (green) and TH (red) in L4 DRG 8 weeks after SNI. A and B, TH-IR fibers surround both non-injured (arrow), and injured cells (arrowhead, ATF3 positive). Not al... |
PMC1950869_F5_13251.jpg | What key item or scene is captured in this photo? | TH-IR and pericellular baskets in injured and non-injured DRG neurons. A to D Representative photomicrograph of double fluorescent immunohistochemistry for ATF3 (green) and TH (red) in L4 DRG 8 weeks after SNI. A and B, TH-IR fibers surround both non-injured (arrow), and injured cells (arrowhead, ATF3 positive). Not al... |
PMC1950869_F5_13249.jpg | What is the core subject represented in this visual? | TH-IR and pericellular baskets in injured and non-injured DRG neurons. A to D Representative photomicrograph of double fluorescent immunohistochemistry for ATF3 (green) and TH (red) in L4 DRG 8 weeks after SNI. A and B, TH-IR fibers surround both non-injured (arrow), and injured cells (arrowhead, ATF3 positive). Not al... |
PMC1950880_F3_13253.jpg | What is the core subject represented in this visual? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13259.jpg | What is the central feature of this picture? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13262.jpg | What is the main focus of this visual representation? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13254.jpg | Can you identify the primary element in this image? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13257.jpg | Can you identify the primary element in this image? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13256.jpg | What is the dominant medical problem in this image? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13258.jpg | What can you see in this picture? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13255.jpg | What is the dominant medical problem in this image? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F3_13260.jpg | What's the most prominent thing you notice in this picture? | Dual Giemsa and SYBR Green 1 staining of P. falciparum inoculated blood. The top panel represents blood films visualized under light microscopy and the lower panel represents the same field visualized using fluorescence microscopy. |
PMC1950880_F4_13263.jpg | What is the dominant medical problem in this image? | LEDs can be used for detecting SYBR stained pRBCs. Fluorescence emission from pRBCs excited with a 5 mW Blue LED powered by 4 AA batteries. The pRBCs were stained with SYBR Green 1 and were then examined using a Zeiss Axiostar Plus microscope with an LED light source fitted in place of its mercury lamp. Photographs dep... |
PMC1950880_F4_13265.jpg | What does this image primarily show? | LEDs can be used for detecting SYBR stained pRBCs. Fluorescence emission from pRBCs excited with a 5 mW Blue LED powered by 4 AA batteries. The pRBCs were stained with SYBR Green 1 and were then examined using a Zeiss Axiostar Plus microscope with an LED light source fitted in place of its mercury lamp. Photographs dep... |
PMC1950880_F4_13264.jpg | What is the focal point of this photograph? | LEDs can be used for detecting SYBR stained pRBCs. Fluorescence emission from pRBCs excited with a 5 mW Blue LED powered by 4 AA batteries. The pRBCs were stained with SYBR Green 1 and were then examined using a Zeiss Axiostar Plus microscope with an LED light source fitted in place of its mercury lamp. Photographs dep... |
PMC1950882_F1_13267.jpg | What is the core subject represented in this visual? | CT Scan of the Pelvis showing prostatic mass. |
PMC1950883_F2_13268.jpg | What is shown in this image? | A: Photomicrograph demonstrating non-Hodgkin's lymphoma of the diffuse large B-cell type, which has uniform, round-to-oval nuclei with vesicular chromatin and one or multiple conspicuous nucleoli (H & E, original magnification × 200). B: These tumor cells are positive for CD20 (Original magnification × 200). |
PMC1950883_F2_13269.jpg | What can you see in this picture? | A: Photomicrograph demonstrating non-Hodgkin's lymphoma of the diffuse large B-cell type, which has uniform, round-to-oval nuclei with vesicular chromatin and one or multiple conspicuous nucleoli (H & E, original magnification × 200). B: These tumor cells are positive for CD20 (Original magnification × 200). |
PMC1950884_F1_13270.jpg | What is the focal point of this photograph? | Macroscopic view of split head of a juvenile alligator. A Lateral view. B Right half of the head showing the incurrent naris and the length of the nasal cavity. * A piece of the septum occludes the nasal cavity. OB – olfactory bulb, VB – vestibule. C Same view as in B depicting the 5 zones that were examined at the lig... |
PMC1950884_F2_13277.jpg | What object or scene is depicted here? | A – D Histological staining nuclear red/light green/orange G. Note that A – D are depicted at the same magnification and that all zones contain OSNs (based on results from semi- and ultrathin sections). A Olfactory epithelium in zone 1 close to the naris. B Ventrolateral olfactory epithelium in zone 2. The height of th... |
PMC1950884_F2_13274.jpg | What is the focal point of this photograph? | A – D Histological staining nuclear red/light green/orange G. Note that A – D are depicted at the same magnification and that all zones contain OSNs (based on results from semi- and ultrathin sections). A Olfactory epithelium in zone 1 close to the naris. B Ventrolateral olfactory epithelium in zone 2. The height of th... |
PMC1950884_F2_13273.jpg | Describe the main subject of this image. | A – D Histological staining nuclear red/light green/orange G. Note that A – D are depicted at the same magnification and that all zones contain OSNs (based on results from semi- and ultrathin sections). A Olfactory epithelium in zone 1 close to the naris. B Ventrolateral olfactory epithelium in zone 2. The height of th... |
PMC1950884_F2_13276.jpg | What is the focal point of this photograph? | A – D Histological staining nuclear red/light green/orange G. Note that A – D are depicted at the same magnification and that all zones contain OSNs (based on results from semi- and ultrathin sections). A Olfactory epithelium in zone 1 close to the naris. B Ventrolateral olfactory epithelium in zone 2. The height of th... |
PMC1950884_F2_13278.jpg | What stands out most in this visual? | A – D Histological staining nuclear red/light green/orange G. Note that A – D are depicted at the same magnification and that all zones contain OSNs (based on results from semi- and ultrathin sections). A Olfactory epithelium in zone 1 close to the naris. B Ventrolateral olfactory epithelium in zone 2. The height of th... |
PMC1950884_F2_13275.jpg | What is the core subject represented in this visual? | A – D Histological staining nuclear red/light green/orange G. Note that A – D are depicted at the same magnification and that all zones contain OSNs (based on results from semi- and ultrathin sections). A Olfactory epithelium in zone 1 close to the naris. B Ventrolateral olfactory epithelium in zone 2. The height of th... |
PMC1950884_F5_13282.jpg | What is the core subject represented in this visual? | SEM micrographs of alligator nasal epithelia. A Fracture of olfactory epithelium in zone 5. With 70 μm this is one of the thinner regions of epithelium on the caudal turbinate. B Overview of nasal epithelium in zone 1 which TEM preparations proved to be olfactory. Arrowheads depict openings of Bowman glands. C Fracture... |
PMC1950884_F5_13284.jpg | What is the core subject represented in this visual? | SEM micrographs of alligator nasal epithelia. A Fracture of olfactory epithelium in zone 5. With 70 μm this is one of the thinner regions of epithelium on the caudal turbinate. B Overview of nasal epithelium in zone 1 which TEM preparations proved to be olfactory. Arrowheads depict openings of Bowman glands. C Fracture... |
PMC1950884_F5_13279.jpg | What can you see in this picture? | SEM micrographs of alligator nasal epithelia. A Fracture of olfactory epithelium in zone 5. With 70 μm this is one of the thinner regions of epithelium on the caudal turbinate. B Overview of nasal epithelium in zone 1 which TEM preparations proved to be olfactory. Arrowheads depict openings of Bowman glands. C Fracture... |
PMC1950886_F4_13287.jpg | Can you identify the primary element in this image? | Echinus does not require deubiquitinating activity to promote normal IOC death. (A-D) SEMs of adult eyes of various genotypes. (E-H) Pupal retinas of various genotypes stained with anti-Dlg. (A,E) GMR-driven expression of a microRNA targeting ec-SF1 results in an echinus phenotype. (B,F) ecEPΔ4 eyes. (C,G) Eyes of geno... |
PMC1950886_F4_13286.jpg | What is the core subject represented in this visual? | Echinus does not require deubiquitinating activity to promote normal IOC death. (A-D) SEMs of adult eyes of various genotypes. (E-H) Pupal retinas of various genotypes stained with anti-Dlg. (A,E) GMR-driven expression of a microRNA targeting ec-SF1 results in an echinus phenotype. (B,F) ecEPΔ4 eyes. (C,G) Eyes of geno... |
PMC1950886_F4_13292.jpg | What object or scene is depicted here? | Echinus does not require deubiquitinating activity to promote normal IOC death. (A-D) SEMs of adult eyes of various genotypes. (E-H) Pupal retinas of various genotypes stained with anti-Dlg. (A,E) GMR-driven expression of a microRNA targeting ec-SF1 results in an echinus phenotype. (B,F) ecEPΔ4 eyes. (C,G) Eyes of geno... |
PMC1950886_F4_13289.jpg | What is shown in this image? | Echinus does not require deubiquitinating activity to promote normal IOC death. (A-D) SEMs of adult eyes of various genotypes. (E-H) Pupal retinas of various genotypes stained with anti-Dlg. (A,E) GMR-driven expression of a microRNA targeting ec-SF1 results in an echinus phenotype. (B,F) ecEPΔ4 eyes. (C,G) Eyes of geno... |
PMC1950886_F4_13291.jpg | Describe the main subject of this image. | Echinus does not require deubiquitinating activity to promote normal IOC death. (A-D) SEMs of adult eyes of various genotypes. (E-H) Pupal retinas of various genotypes stained with anti-Dlg. (A,E) GMR-driven expression of a microRNA targeting ec-SF1 results in an echinus phenotype. (B,F) ecEPΔ4 eyes. (C,G) Eyes of geno... |
PMC1950886_F4_13288.jpg | What is the core subject represented in this visual? | Echinus does not require deubiquitinating activity to promote normal IOC death. (A-D) SEMs of adult eyes of various genotypes. (E-H) Pupal retinas of various genotypes stained with anti-Dlg. (A,E) GMR-driven expression of a microRNA targeting ec-SF1 results in an echinus phenotype. (B,F) ecEPΔ4 eyes. (C,G) Eyes of geno... |
PMC1950887_F1_13297.jpg | What's the most prominent thing you notice in this picture? | A & B: Axial and sagital view of 18FDG-PET scan of the patient showing region of 18FDG uptake anterior to the vertebral body. C: CT scan of the positive region identified on the 18FDG-PET scan. D: MRI of the thoracic spine in the region identified on the PET scan. E & F: Axial and sagital view of PET/CT scan of the pat... |
PMC1950887_F1_13299.jpg | What is the main focus of this visual representation? | A & B: Axial and sagital view of 18FDG-PET scan of the patient showing region of 18FDG uptake anterior to the vertebral body. C: CT scan of the positive region identified on the 18FDG-PET scan. D: MRI of the thoracic spine in the region identified on the PET scan. E & F: Axial and sagital view of PET/CT scan of the pat... |
PMC1950887_F1_13298.jpg | What object or scene is depicted here? | A & B: Axial and sagital view of 18FDG-PET scan of the patient showing region of 18FDG uptake anterior to the vertebral body. C: CT scan of the positive region identified on the 18FDG-PET scan. D: MRI of the thoracic spine in the region identified on the PET scan. E & F: Axial and sagital view of PET/CT scan of the pat... |
PMC1950887_F1_13302.jpg | What key item or scene is captured in this photo? | A & B: Axial and sagital view of 18FDG-PET scan of the patient showing region of 18FDG uptake anterior to the vertebral body. C: CT scan of the positive region identified on the 18FDG-PET scan. D: MRI of the thoracic spine in the region identified on the PET scan. E & F: Axial and sagital view of PET/CT scan of the pat... |
PMC1950887_F1_13301.jpg | What can you see in this picture? | A & B: Axial and sagital view of 18FDG-PET scan of the patient showing region of 18FDG uptake anterior to the vertebral body. C: CT scan of the positive region identified on the 18FDG-PET scan. D: MRI of the thoracic spine in the region identified on the PET scan. E & F: Axial and sagital view of PET/CT scan of the pat... |
PMC1950887_F1_13303.jpg | What is being portrayed in this visual content? | A & B: Axial and sagital view of 18FDG-PET scan of the patient showing region of 18FDG uptake anterior to the vertebral body. C: CT scan of the positive region identified on the 18FDG-PET scan. D: MRI of the thoracic spine in the region identified on the PET scan. E & F: Axial and sagital view of PET/CT scan of the pat... |
PMC1950887_F2_13294.jpg | Can you identify the primary element in this image? | A: Haematoxylin and eosin stained section of the tumour resected from the mediastinal of the patient (100× magnification). The tumour nodule showed evidence of organoid arrangement. B: Section of the resected tumour showing tumour cells expressing AFP, as detected by immunohistochemistry (600× magnification). C: Graph ... |
PMC1950887_F2_13293.jpg | What does this image primarily show? | A: Haematoxylin and eosin stained section of the tumour resected from the mediastinal of the patient (100× magnification). The tumour nodule showed evidence of organoid arrangement. B: Section of the resected tumour showing tumour cells expressing AFP, as detected by immunohistochemistry (600× magnification). C: Graph ... |
PMC1950908_pone-0000794-g001_13304.jpg | What does this image primarily show? | Analysis of interneuron-radial glial interactions in the embryonic cerebral cortex.(A) Interneurons express GFP in a coronal slice of E16 cortex from Dlx5/6-cre-IRES-EGFP (Dlx5/6-CIE) mice. Radial glial scaffold is labeled with RC2 antibodies (blue). (B–D) Higher magnification view of the outlined region (B, radial gli... |
PMC1950908_pone-0000794-g001_13308.jpg | What is being portrayed in this visual content? | Analysis of interneuron-radial glial interactions in the embryonic cerebral cortex.(A) Interneurons express GFP in a coronal slice of E16 cortex from Dlx5/6-cre-IRES-EGFP (Dlx5/6-CIE) mice. Radial glial scaffold is labeled with RC2 antibodies (blue). (B–D) Higher magnification view of the outlined region (B, radial gli... |
PMC1950908_pone-0000794-g001_13306.jpg | What is shown in this image? | Analysis of interneuron-radial glial interactions in the embryonic cerebral cortex.(A) Interneurons express GFP in a coronal slice of E16 cortex from Dlx5/6-cre-IRES-EGFP (Dlx5/6-CIE) mice. Radial glial scaffold is labeled with RC2 antibodies (blue). (B–D) Higher magnification view of the outlined region (B, radial gli... |
PMC1951782_pbio-0050233-g004_13309.jpg | What stands out most in this visual? | Smooth, Canoe-Shaped Keratocytes Migrate “Coherently,” with Fast Speeds and Persistent ShapesOutlines of migrating keratocytes overexpressing EGFP-VASP were generated from each frame of time-lapse image sequences separated by 10 s to examine the shape of cells as they migrate. Outlines are colored from blue to red to r... |
PMC1952065_F1_13313.jpg | What object or scene is depicted here? | CT scan of the pancreatic cystic teratoma. Computed tomography showing a 5 cm cystic fluid mass arising from the tail of the pancreas. |
PMC1952073_pone-0000844-g007_13317.jpg | What is the core subject represented in this visual? | Live cell confocal microscopy confirms NDRG1 involvement with recycling E-cadherin.Live cell confocal images of stable NDRG1DsRed2-HEK293 cells transfected transiently with E-cadherinEGFP construct and plated in calcium-supplemented media after being chelated with EDTA shows NDRG1DsRed2 positive vesicles interact with ... |
PMC1952073_pone-0000844-g007_13316.jpg | What can you see in this picture? | Live cell confocal microscopy confirms NDRG1 involvement with recycling E-cadherin.Live cell confocal images of stable NDRG1DsRed2-HEK293 cells transfected transiently with E-cadherinEGFP construct and plated in calcium-supplemented media after being chelated with EDTA shows NDRG1DsRed2 positive vesicles interact with ... |
PMC1952073_pone-0000844-g007_13315.jpg | What's the most prominent thing you notice in this picture? | Live cell confocal microscopy confirms NDRG1 involvement with recycling E-cadherin.Live cell confocal images of stable NDRG1DsRed2-HEK293 cells transfected transiently with E-cadherinEGFP construct and plated in calcium-supplemented media after being chelated with EDTA shows NDRG1DsRed2 positive vesicles interact with ... |
PMC1952109_pone-0000843-g002_13320.jpg | What object or scene is depicted here? | Diffusely-stained astrocytes are prevalent in confocal images from mutant mice.(A) Example of confocal images from DAF-2DA incubated neocortical slices. Punctate, putative neuronal staining is dominating in slices from control mice (left), and diffuse fluorescence is dominating in the mutant's slice (right). Scale bar ... |
PMC1952109_pone-0000843-g002_13321.jpg | What key item or scene is captured in this photo? | Diffusely-stained astrocytes are prevalent in confocal images from mutant mice.(A) Example of confocal images from DAF-2DA incubated neocortical slices. Punctate, putative neuronal staining is dominating in slices from control mice (left), and diffuse fluorescence is dominating in the mutant's slice (right). Scale bar ... |
PMC1952109_pone-0000843-g002_13322.jpg | What is the core subject represented in this visual? | Diffusely-stained astrocytes are prevalent in confocal images from mutant mice.(A) Example of confocal images from DAF-2DA incubated neocortical slices. Punctate, putative neuronal staining is dominating in slices from control mice (left), and diffuse fluorescence is dominating in the mutant's slice (right). Scale bar ... |
PMC1952109_pone-0000843-g002_13323.jpg | What is the core subject represented in this visual? | Diffusely-stained astrocytes are prevalent in confocal images from mutant mice.(A) Example of confocal images from DAF-2DA incubated neocortical slices. Punctate, putative neuronal staining is dominating in slices from control mice (left), and diffuse fluorescence is dominating in the mutant's slice (right). Scale bar ... |
PMC1952109_pone-0000843-g004_13325.jpg | What object or scene is depicted here? | Mutant astroglial NOS activity is unaffected by NOS2 inhibitor.Example images from slices incubated in the selective NOS2 inhibitor 1400W (3 µM) for at least 30 minutes. At 30 seconds from the beginning of illumination (left panels), neuronal punctate fluorescence (arrow heads) was abundant in slices from either mutant... |
PMC1952109_pone-0000843-g004_13324.jpg | What object or scene is depicted here? | Mutant astroglial NOS activity is unaffected by NOS2 inhibitor.Example images from slices incubated in the selective NOS2 inhibitor 1400W (3 µM) for at least 30 minutes. At 30 seconds from the beginning of illumination (left panels), neuronal punctate fluorescence (arrow heads) was abundant in slices from either mutant... |
PMC1952176_pone-0000834-g001_13332.jpg | What is shown in this image? | The raw data produced by OPT.
Drosophila cleared in Murray's clear, is almost transparent when imaged under brightfield conditions (A–B). The cleared fly allows full excitation and emission of fluorescent light when excited at 480±40 nm (C–F). w1118, and Cha>GFP
[30] both have detectable levels of autofluorescence (C–D... |
PMC1952176_pone-0000834-g001_13331.jpg | What is the core subject represented in this visual? | The raw data produced by OPT.
Drosophila cleared in Murray's clear, is almost transparent when imaged under brightfield conditions (A–B). The cleared fly allows full excitation and emission of fluorescent light when excited at 480±40 nm (C–F). w1118, and Cha>GFP
[30] both have detectable levels of autofluorescence (C–D... |
PMC1952176_pone-0000834-g001_13328.jpg | Can you identify the primary element in this image? | The raw data produced by OPT.
Drosophila cleared in Murray's clear, is almost transparent when imaged under brightfield conditions (A–B). The cleared fly allows full excitation and emission of fluorescent light when excited at 480±40 nm (C–F). w1118, and Cha>GFP
[30] both have detectable levels of autofluorescence (C–D... |
PMC1952176_pone-0000834-g001_13330.jpg | What is the dominant medical problem in this image? | The raw data produced by OPT.
Drosophila cleared in Murray's clear, is almost transparent when imaged under brightfield conditions (A–B). The cleared fly allows full excitation and emission of fluorescent light when excited at 480±40 nm (C–F). w1118, and Cha>GFP
[30] both have detectable levels of autofluorescence (C–D... |
PMC1952176_pone-0000834-g002_13337.jpg | What does this image primarily show? | The data output.The data from the scans are reconstructed in 3D, the two datasets, brightfield (red, exoskeleton) and fluorescent (green, anatomy), are superimposed, and the information is displayed in all three planes (A–D). Single heads can be imaged (E). The data can also be displayed and explored in 3D (F, G). |
PMC1952176_pone-0000834-g002_13335.jpg | What is being portrayed in this visual content? | The data output.The data from the scans are reconstructed in 3D, the two datasets, brightfield (red, exoskeleton) and fluorescent (green, anatomy), are superimposed, and the information is displayed in all three planes (A–D). Single heads can be imaged (E). The data can also be displayed and explored in 3D (F, G). |
PMC1952176_pone-0000834-g002_13340.jpg | What can you see in this picture? | The data output.The data from the scans are reconstructed in 3D, the two datasets, brightfield (red, exoskeleton) and fluorescent (green, anatomy), are superimposed, and the information is displayed in all three planes (A–D). Single heads can be imaged (E). The data can also be displayed and explored in 3D (F, G). |
PMC1952176_pone-0000834-g002_13336.jpg | What object or scene is depicted here? | The data output.The data from the scans are reconstructed in 3D, the two datasets, brightfield (red, exoskeleton) and fluorescent (green, anatomy), are superimposed, and the information is displayed in all three planes (A–D). Single heads can be imaged (E). The data can also be displayed and explored in 3D (F, G). |
PMC1952176_pone-0000834-g002_13339.jpg | What does this image primarily show? | The data output.The data from the scans are reconstructed in 3D, the two datasets, brightfield (red, exoskeleton) and fluorescent (green, anatomy), are superimposed, and the information is displayed in all three planes (A–D). Single heads can be imaged (E). The data can also be displayed and explored in 3D (F, G). |
PMC1952176_pone-0000834-g003_13347.jpg | Can you identify the primary element in this image? | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g003_13344.jpg | What is the principal component of this image? | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g003_13341.jpg | Can you identify the primary element in this image? | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g003_13346.jpg | What is the principal component of this image? | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g003_13345.jpg | Describe the main subject of this image. | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g003_13342.jpg | What is the central feature of this picture? | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g003_13348.jpg | Describe the main subject of this image. | Visualizing through the head cuticle with confocal microscopy.The CNS can be visualized through the cleared head. Both w1118 (A–F) and Cha>GFP (G–H) were visualized. The brain was imaged from the front (A–C, and G–H) and back (D–F) and structures such as the fan shaped body and ellipsoid body were detected (H arrow and... |
PMC1952176_pone-0000834-g004_13350.jpg | Describe the main subject of this image. | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13349.jpg | What is the central feature of this picture? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13359.jpg | What is the principal component of this image? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13357.jpg | What can you see in this picture? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13358.jpg | Describe the main subject of this image. | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13352.jpg | What is the core subject represented in this visual? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13351.jpg | What does this image primarily show? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13355.jpg | What stands out most in this visual? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13353.jpg | Can you identify the primary element in this image? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13360.jpg | What is the principal component of this image? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952176_pone-0000834-g004_13356.jpg | What is being portrayed in this visual content? | Identification of neurodegenerative vacuoles using OPT.OPT was used to identify regions of neurodegeneration in the brains of flies lacking the RNA editing enzyme Adar. Regions that lacked fluorescence were identified from sections in different orientations (A–C) and then these potential vacuoles were highlighted as do... |
PMC1952177_pone-0000848-g004_13368.jpg | What object or scene is depicted here? | The fine structure of large and small prefrontal terminations in the ventral anterior nucleus.The photographs were obtained from single two-dimensional sections. A–C, Electron microscopic (EM) photomicrographs showing small labeled boutons (sb) forming synapses with PV+ dendrites (d; black rods or grains, yellow arrowh... |
PMC1952177_pone-0000848-g004_13365.jpg | What can you see in this picture? | The fine structure of large and small prefrontal terminations in the ventral anterior nucleus.The photographs were obtained from single two-dimensional sections. A–C, Electron microscopic (EM) photomicrographs showing small labeled boutons (sb) forming synapses with PV+ dendrites (d; black rods or grains, yellow arrowh... |
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