virx/molecule · Datasets at Hugging Face

instruction stringlengths 41 142	input stringlengths 0 478	output stringlengths 4 382
Deconstruct the reaction template <RNX_0> into a set of instructions defining the required reactant types and the resulting product pattern.	[cH1:1]1:[c:2](-[CH2:7]-[CH2:8]-[NH2:9]):[c:3]:[c:4]:[c:5]:[c:6]:1.[#6:11]-[CH1;R0:10]=[OD1]>>[c:1]12:[c:2](-[CH2:7]-[CH2:8]-[NH1:9]-[C:10]-2(-[#6:11])):[c:3]:[c:4]:[c:5]:[c:6]:1	Reaction Type: Synthesis Reactant 1: Requires phenethylamine. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_1> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;r6:1](-[NH1;$(N-[#6]):2]):[c;r6:3](-[NH2:4]).[#6:6]-[C;R0:5](=[OD1])-[#8;H1,$(O-[CH3])]>>[c:3]2:[c:1]:[n:2]:[c:5](-[#6:6]):[n:4]2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms imidazole ring.
Deconstruct the reaction template <RNX_2> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;r6:1](-[NH1;$(N-[#6]):2]):[c;r6:3](-[NH2:4]).[#6:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[n:2]:[c:5](-[#6:6]):[n:4]2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms imidazole ring.
Deconstruct the reaction template <RNX_3> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;r6:1](-[SH1:2]):[c;r6:3](-[NH2:4]).[#6:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[s:2]:[c:5](-[#6:6]):[n:4]2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms thiazole ring.
Deconstruct the reaction template <RNX_4> into a set of instructions defining the required reactant types and the resulting product pattern.	[c:1](-[OH1;$(Oc1ccccc1):2]):[c;r6:3](-[NH2:4]).[c:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[o:2]:[c:5](-[c:6]):[n:4]2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_5> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;r6:1](-[OH1:2]):[c;r6:3](-[NH2:4]).[#6:6]-[C;R0:5](=[OD1])-[OH1]>>[c:3]2:[c:1]:[o:2]:[c:5](-[#6:6]):[n:4]2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_6> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:6]-[C;R0:1](=[OD1])-[CH1;R0:5](-[#6:7])-[#17].[NH2:2]-[C:3]=[SD1:4]>>[c:1]2(-[#6:6]):[n:2]:[c:3]:[s:4][c:5]([#6:7]):2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires thioamide. Product: Forms thiazole ring.
Deconstruct the reaction template <RNX_7> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:6]-[C;R0:1](=[OD1])-[CH1;R0:5](-[#6:7])-[#35].[NH2:2]-[C:3]=[SD1:4]>>[c:1]2(-[#6:6]):[n:2]:[c:3]:[s:4][c:5]([#6:7]):2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires thioamide. Product: Forms thiazole ring.
Deconstruct the reaction template <RNX_8> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:6]-[C;R0:1](=[OD1])-[CH1;R0:5](-[#6:7])-[#53].[NH2:2]-[C:3]=[SD1:4]>>[c:1]2(-[#6:6]):[n:2]:[c:3]:[s:4][c:5]([#6:7]):2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires thioamide. Product: Forms thiazole ring.
Deconstruct the reaction template <RNX_9> into a set of instructions defining the required reactant types and the resulting product pattern.	[c:1](-[C;$(C-c1ccccc1):2](=[OD1:3])-[OH1]):[c:4](-[NH2:5]).[N;!H0;!$(N-N);!$(N-C=N);!$(N(-C=O)-C=O):6]-[C;H1,$(C-[#6]):7]=[OD1]>>[c:4]2:[c:1]-[C:2](=[O:3])-[N:6]-[C:7]=[N:5]-2	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_10> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2]>>[C:1]1=[N:2]-N-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_11> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#17]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_12> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#35]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_13> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#53]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_14> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#17]>>[C:1]1=[N:2]-N=N-N-1(-[C:3])	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_15> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#35]>>[C:1]1=[N:2]-N=N-N-1(-[C:3])	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_16> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#53]>>[C:1]1=[N:2]-N=N-N-1(-[C:3])	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_17> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#17]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_18> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#35]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_19> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#53]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_20> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[OH1]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-hydroxyaniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_21> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#17]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_22> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#35]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_23> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#53]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_24> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[OH1]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-hydroxyaniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_25> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[#17]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_26> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[#35]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_27> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[#53]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_28> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[OH1]>>[C:1]1=[C:2]-N=NN(-[C:3])-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-hydroxyaniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_29> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[NH2:3]-[NH1:4]-[CH0;$(C-[#6]);R0:5]=[OD1]>>[N:2]1-[C:1]=[N:3]-[N:4]-[C:5]=1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_30> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH0;$(C-[#6]):1]#[NH0:2].[CH0;$(C-[#6]);R0:5](=[OD1])-[#8;H1,$(O-[CH3]),$(O-[CH2]-[CH3])]>>[N:2]1-[C:1]=N-N-[C:5]=1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_31> into a set of instructions defining the required reactant types and the resulting product pattern.	[c:1](-[C;$(C-c1ccccc1):2](=[OD1:3])-[CH3:4]):[c:5](-[OH1:6]).[C;$(C1-[CH2]-[CH2]-[N,C]-[CH2]-[CH2]-1):7](=[OD1])>>[O:6]1-[c:5]:[c:1]-[C:2](=[OD1:3])-[C:4]-[C:7]-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_32> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;r6:1](-[C;$(C=O):6]-[OH1]):[c;r6:2]-[C;H1,$(C-C):3]=[OD1].[NH2:4]-[NH1;$(N-[#6]);!$(NC=[O,S,N]):5]>>[c:1]1:[c:2]-[C:3]=[N:4]-[N:5]-[C:6]-1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_33> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;$(C-c1ccccc1):1](=[OD1])-[C;D3;$(C-c1ccccc1):2]~[O;D1,H1].[CH1;$(C-c):3]=[OD1]>>[C:1]1-N=[C:3]-[NH1]-[C:2]=1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms imidazole ring.
Deconstruct the reaction template <RNX_34> into a set of instructions defining the required reactant types and the resulting product pattern.	[NH2;$(N-c1ccccc1):1]-[c:2]:[c:3]-[CH1:4]=[OD1].[C;$(C([#6])[#6]):6](=[OD1])-[CH2;$(C([#6])[#6]);!$(C(C=O)C=O):5]>>[N:1]1-[c:2]:[c:3]-[C:4]=[C:5]-[C:6]:1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_35> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:6][C:5]#[#7;D1:4].[#6:1][C:2](=[OD1:3])[OH1]>>[#6:6][c:5]1[n:4][o:3][c:2]([#6:1])n1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_36> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;H1:3]1:[c:4]:[c:5]:[c;H1:6]:[c:7]2:[nH:8]:[c:9]:[c;H1:1]:[c:2]:1:2.O=[C:10]1[#6;H2:11][#6;H2:12][N:13][#6;H2:14][#6;H2:15]1>>[#6;H2:12]3[#6;H1:11]=[C:10]([c:1]1:[c:9]:[n:8]:[c:7]2:[c:6]:[c:5]:[c:4]:[c:3]:[c:2]:1:2)[#6;H2:15][#6;H2:14][N:13]3	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_37> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[OH1;$(Oc1ccccc1):2]>>[C:1][O:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_38> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7H1:2]1~[#7:3]~[#7:4]~[#7:5]~[#6:6]~1>>[C:1][#7:2]1:[#7:3]:[#7:4]:[#7:5]:[#6:6]:1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_39> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7H1:2]1~[#7:3]~[#7:4]~[#7:5]~[#6:6]~1>>[#7H0:2]1:[#7:3]:[#7H0:4]([C:1]):[#7:5]:[#6:6]:1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_40> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7:2]1~[#7:3]~[#7H1:4]~[#7:5]~[#6:6]~1>>[C:1][#7H0:2]1:[#7:3]:[#7H0:4]:[#7:5]:[#6:6]:1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_41> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7:2]1~[#7:3]~[#7H1:4]~[#7:5]~[#6:6]~1>>[#7:2]1:[#7:3]:[#7:4]([C:1]):[#7:5]:[#6:6]:1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms tetrazole ring.
Deconstruct the reaction template <RNX_42> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:1][C:2]#[#7;D1].[Cl][#6;$([#6]~[#6]);!$([#6]([Cl,Br,I])[Cl,Br,I]);!$([#6]=O):3]>>[#6:1][C:2](=O)[#6:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_43> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:1][C:2]#[#7;D1].[Br][#6;$([#6]~[#6]);!$([#6]([Cl,Br,I])[Cl,Br,I]);!$([#6]=O):3]>>[#6:1][C:2](=O)[#6:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_44> into a set of instructions defining the required reactant types and the resulting product pattern.	[#6:1][C:2]#[#7;D1].[I][#6;$([#6]~[#6]);!$([#6]([Cl,Br,I])[Cl,Br,I]);!$([#6]=O):3]>>[#6:1][C:2](=O)[#6:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_45> into a set of instructions defining the required reactant types and the resulting product pattern.	[S;$(S(=O)(=O)[C,N]):1][Cl].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[S:1][N+0:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_46> into a set of instructions defining the required reactant types and the resulting product pattern.	[C;$(C([#6])[#6;!$([#6]Br)]):4](=[OD1])[CH;$(C([#6])[#6]):5]Br.[#7;H2:3][C;$(C(=N)(N)[c,#7]):2]=[#7;H1;D1:1]>>[C:4]1=[CH0:5][NH:3][C:2]=[N:1]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_47> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;!$(c1ccccc1);$(c1[n,c]c[n,c]c[n,c]1):1][Cl].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_48> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;!$(c1ccccc1);$(c1[n,c]c[n,c]c[n,c]1):1][F].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_49> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;$(c1c(N(~O)~O)cccc1):1][Cl].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_50> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;$(c1c(N(~O)~O)cccc1):1][F].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_51> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;$(c1ccc(N(~O)~O)cc1):1][F].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_52> into a set of instructions defining the required reactant types and the resulting product pattern.	[c;$(c1ccc(N(~O)~O)cc1):1][Cl].[N;$(NC);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_53> into a set of instructions defining the required reactant types and the resulting product pattern.	[N;$(N-[#6]):3]=[C;$(C=O):1].[N;$(N[#6]);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[O,N]);!$(N[C,S]=[S,O,N]):2]>>[N:3]-[C:1]-[N+0:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_54> into a set of instructions defining the required reactant types and the resulting product pattern.	[N;$(N-[#6]):3]=[C;$(C=S):1].[N;$(N[#6]);!$(N=);!$([N-]);!$(N#);!$([ND3]);!$([ND4]);!$(N[O,N]);!$(N[C,S]=[S,O,N]):2]>>[N:3]-[C:1]-[N+0:2]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_55> into a set of instructions defining the required reactant types and the resulting product pattern.	[$(C([CH2,CH3])),CH:10](=[O:11])-[NH+0:9]-[C$(C(N)(C)(C)(C)),C$([CH](N)(C)(C)),C$([CH2](N)(C)):8]-[C$(C(c)(C)(C)(C)),C$([CH](c)(C)(C)),C$([CH2](c)(C)):7]-[c:6]1[cH:1][c:2][c:3][c:4][c:5]1>>[C:10]-1=[N+0:9]-[C:8]-[C:7]-[c:6]2[c:5][c:4][c:3][c:2][c:1]-12	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_56> into a set of instructions defining the required reactant types and the resulting product pattern.	[$(C([CH2,CH3])),CH:10](=[O:11])-[NH+0:9]-[C$([CH](N)(C)(C)),C$([CH2](N)(C)):8]-[C$([C](c)(C)(C)),C$([CH](c)(C)):7]([O$(OC),OH])-[c:6]1[cH:1][c:2][c:3][c:4][c:5]1>>[c:10]-1[n:9][c:8][c:7][c:6]2[c:5][c:4][c:3][c:2][c:1]-12	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_57> into a set of instructions defining the required reactant types and the resulting product pattern.	[NH3+,NH2]-[C$(C(N)(C)(C)(C)),C$([CH](N)(C)(C)),C$([CH2](N)(C)):8]-[C$(C(c)(C)(C)(C)),C$([CH](c)(C)(C)),C$([CH2](c)(C)):7]-[c:6]1[c:1][c:2][nH:3][cH:5]1.[CH:10](-[CX4:12])=[O:11]>>[c,C:12]-[CH:10]-1-[N]-[C:8]-[C:7]-[c:6]2[c:1][c:2][nH:3][c:5]-12	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_58> into a set of instructions defining the required reactant types and the resulting product pattern.	[NH2,NH3+1:8]-[c:5]1[cH:4][c:3][c:2][c:1][c:6]1.[Br:18][C$([CH2](C)(Br)),C$([CH](C)(C)(Br)):17]-[C:15](=[O:16])-[c:10]1[c:11][c:12][c:13][c:14][c:9]1>>[c:13]1[c:12][c:11][c:10]([c:9][c:14]1)-[c:15]1[c:17][c:4]2[c:3][c:2][c:1][c:6][c:5]2[nH+0:8]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_59> into a set of instructions defining the required reactant types and the resulting product pattern.	[Cl:1][CH2:2]-[C$([CH](C)),C$(C(C)(C)):3]=[O:4].[OH:12]-[c:11]1[c:6][c:7][c:8][c:9][c:10]1-[CH:13]=[O:14]>>[C:3](=[O:4])-[c:2]1[c:13][c:10]2[c:9][c:8][c:7][c:6][c:11]2[o:12]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_60> into a set of instructions defining the required reactant types and the resulting product pattern.	[NH2,NH3+]-[C$([CX4](N)([c,C])([c,C])([c,C])),C$([CH](N)([c,C])([c,C])),C$([CH2](N)([c,C])),C$([CH3](N)):2].[NH2:12]-[c:7]1[c:6][c:5][c:4][c:3][c:8]1-[C:9](-[OH,O-:11])=[O:10]>>[C:2]-[n+0]-1[c:13][n:12][c:7]2[c:6][c:5][c:4][c:3][c:8]2[c:9]-1=[O:10]	Reaction Type: Synthesis Reactant 1: Requires phenethylamine. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_61> into a set of instructions defining the required reactant types and the resulting product pattern.	[N$([NH2]([CX4])),N$([NH3+1]([CX4])):1].[O:5]-[C$([CH]([CX4])(C)(O)),C$([CH2]([CX4])(O)):3][C$(C([CX4])(=O)([CX4])),C$([CH]([CX4])(=O)):4]=[O:6]>[O:15]=[C:9]-1-[CH2:10]-[CH2:11]-[CH2:12]-[CH2:13]-[CH2:14]-1>[C:4]1[C:3][N+0:1][C:10]2-[C:11]-[C:12]-[C:13]-[C:14]-[C:9]12	Reaction Type: Synthesis Reactant 1: Requires phenethylamine. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_62> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(=O)([CX4])([CX4])),C$([CH](=O)([CX4])):2](=[O:6])-[C$([CH]([CX4])),C$([CH2]):3]-[C$(C(=O)([CX4])([CX4])),C$([CH](=O)([CX4])):4]=[O:7].[NH2:8]-[C:9](=[O:10])-[CH2:11][C:12]#[N:13]>>[OH:10]-[c:9]1[n:8][c:4][c:3][c:2][c:11]1[C:12]#[N:13]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_63> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(#C)([CX4])):2]#[C$(C(#C)([CX4])):1].[N$(N(~N)([CX4])):5]=[N+]=[N-]>>[c:2]1[c:1][n:5][n][n]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_64> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(=C)([CX4])):2]=[C$(C(=C)([CX4])):1].[N$(N(~N)([CX4&D1])):5]~[N]~[N]>>[C:2]1[C:1][N:5][N]=[N]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_65> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):1]=[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):2].[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):3]=[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):4]-[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):5]=[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):6]>>[C:1]1[C:2][C:3][C:4]=[C:5][C:6]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_66> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(#C)([CX4,OX2,NX3])),C$([CH](#C)):1]#[C$(C(#C)([CX4,OX2,NX3])),C$([CH](#C)):2].[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):3]=[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):4]-[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):5]=[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):6]>>[C:1]1=[C:2][C:3][C:4]=[C:5][C:6]1	Reaction Type: Synthesis Reactant 1: Requires alkyne. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_67> into a set of instructions defining the required reactant types and the resulting product pattern.	[CH:7](=[O:8])-[c:1]1[c:2][c:3][c:4][c:5][c:6]1.[O:24]=[C:23](-[C:22](=[O:25])-[c:15]1[c:10][c:11][c:12][c:13][c:14]1)-[c:20]1[c:21][c:16][c:17][c:18][c:19]1>[NH4].[O-]C(=O)C>[nH:27]-1[c:7]([n:26][c:23]([c:22]-1[c:15]1[c:10][c:11][c:12][c:13][c:14]1)-[c:20]1[c:21][c:16][c:17][c:18][c:19]1)-[c:1]1[c:2][c:3][c:4][c:5][c:6]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms imidazole ring.
Deconstruct the reaction template <RNX_68> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH:7]-[c:6]1[cH:1][c:2][c:3][c:4][c:5]1.[O$(O(C)([CX4])):12]-[C:11](=[O:15])-[C$([CH](C)(C)([CX4])),C$([CH2](C)(C)):10]-[C:8]=[O:16]>>[C:8]-1=[C:10]-[C:11](=[O:15])-[O]-[C:6]2[C:5][C:4][C:3][C:2][C:1]-12	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_69> into a set of instructions defining the required reactant types and the resulting product pattern.	[O$(O(C)([CX4])):8][C:7](=[O:9])[CH:6][C:5][C:4][C:3][C:2]([O$(O(C)([CX4])):10])=[O:1]>>[O:8][C:7](=[O:9])[C:6]1[C:5][C:4][C:3][C:2]1=[O:1]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_70> into a set of instructions defining the required reactant types and the resulting product pattern.	[O$(O(C)([CX4])):8][C:7](=[O:9])[CH:6][C:5][C:11][C:4][C:3][C:2]([O$(O(C)([CX4])):10])=[O:1]>>[O:8][C:7](=[O:9])[C:6]1[C:5][C:11][C:4][C:3][C:2]1=[O:1]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_71> into a set of instructions defining the required reactant types and the resulting product pattern.	[Cl:9][C:7](=[O:8])-[c:3]1[c:2][c:1][c:6][c:5][c:4]1.[C$([CH2](C)([CX4])),C$([CH3](C)):18]-[C:16](=[O:17])-[c:14]1[c:13][c:12][c:11][c:10][c:15]1-[OH:19]>>[O:17]=[C:16]-1-[C:18]=[C:7](-[O:8]-[c:15]2[c:10][c:11][c:12][c:13][c:14]-12)-[c:3]1[c:2][c:1][c:6][c:5][c:4]1	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_72> into a set of instructions defining the required reactant types and the resulting product pattern.	[Cl:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[O$([OH]([CX4,c])),O$([OH]([CX4,c])([CX4,c])),S$([SH]([CX4,c])),S$([SH]([CX4,c])([CX4,c])):6]>>[*:6]-[C:2]=[O:4]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_73> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[O$([OH]([CX4,c])),O$([OH]([CX4,c])([CX4,c])),S$([SH]([CX4,c])),S$([SH]([CX4,c])([CX4,c])):6]>>[*:6]-[C:2]=[O:4]	Reaction Type: Synthesis Reactant 1: Requires carboxylic acid. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_74> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH]-[C$(C(=O)(O)([CX4,c])):2]=[O:3].[OH:8]-[C$([CH](O)([CX4,c])([CX4,c])),C$([CH2](O)([CX4,c])),C$([CH3](O)):6]>>[C:6][O]-[C:2]=[O:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_75> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([CH](=C)([CX4])),C$([CH2](=C)):2]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):3].[Br:7][C$([CX4]([Br])),c$([c]([Br])):4]>>[C,c:4][C:2]=[C:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_76> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([CH](=C)([CX4])),C$([CH2](=C)):2]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):3].[I:7][C$([CX4]([I])),c$([c]([I])):4]>>[C,c:4][C:2]=[C:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_77> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[N$([NH2,NH3+1]([CX4,c])),N$([NH]([CX4,c])([CX4,c])):6]>>[N+0:6]-[C:2]=[O:4]	Reaction Type: Synthesis Reactant 1: Requires carboxylic acid. Reactant 2: Requires phenethylamine. Product: Forms a generic product.
Deconstruct the reaction template <RNX_78> into a set of instructions defining the required reactant types and the resulting product pattern.	[Cl:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[N$([NH2,NH3+1]([CX4,c])),N$([NH]([CX4,c])([CX4,c])):6]>>[N+0:6]-[C:2]=[O:4]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires phenethylamine. Product: Forms a generic product.
Deconstruct the reaction template <RNX_79> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):1]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):2].[SH:4]-[CX4:5][Br]>>[C:1]-[C:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_80> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):1]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):2].[SH:4]-[CX4:5][Cl]>>[C:1]-[C:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_81> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):1]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):2].[SH:4]-[CX4:5][I]>>[C:1]-[C:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_82> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[OH:6].[SH:4]-[CX4:5][Br]>>[CH2:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires carboxylic acid. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_83> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[OH:6].[SH:4]-[CX4:5][Cl]>>[CH2:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires carboxylic acid. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_84> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[OH:6].[SH:4]-[CX4:5][I]>>[CH2:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires carboxylic acid. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_85> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[Cl:6].[SH:4]-[CX4:5][Br]>>[CH2:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_86> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[Cl:6].[SH:4]-[CX4:5][Cl]>>[CH2:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_87> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[Cl:6].[SH:4]-[CX4:5][I]>>[CH2:2]-[S:4][C:5]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_88> into a set of instructions defining the required reactant types and the resulting product pattern.	[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([Cl])([CX4,c])),C$([CH]([Cl])(=O)):3](=[O:6])[Cl:5]>>[C:2]-[C:3]=[O:6]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_89> into a set of instructions defining the required reactant types and the resulting product pattern.	[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([OH])([CX4,c])),C$([CH]([OH])(=O)):3](=[O:6])[Cl:5]>>[C:2]-[C:3]=[O:6]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_90> into a set of instructions defining the required reactant types and the resulting product pattern.	[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([Cl])([CX4,c])),C$([CH]([Cl])(=O)):3](=[O:6])[OH:5]>>[C:2]-[C:3]=[O:6]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_91> into a set of instructions defining the required reactant types and the resulting product pattern.	[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([OH])([CX4,c])),C$([CH]([OH])(=O)):3](=[O:6])[OH:5]>>[C:2]-[C:3]=[O:6]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires carboxylic acid. Product: Forms a generic product.
Deconstruct the reaction template <RNX_92> into a set of instructions defining the required reactant types and the resulting product pattern.	[Cl:5][S$(S(=O)(=O)(Cl)([CX4])):2](=[O:3])=[O:4].[NH2+0,NH3+:6]-[C$(C(N)([CX4,c])([CX4,c])([CX4,c])),C$([CH](N)([CX4,c])([CX4,c])),C$([CH2](N)([CX4,c])),C$([CH3](N)),c$(c(N)):7]>>[C,c:7]-[NH+0:6][S:2](=[O:4])=[O:3]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires ortho-amino-N-substituted-aniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_93> into a set of instructions defining the required reactant types and the resulting product pattern.	[:1][C:2]#[CH:3].[Br:4][C$(C([CX4,c])([CX4,c])([CX4,c])),C$([CH]([CX4,c])([CX4,c])),C$([CH2]([CX4,c])),C$([CH3]),c$(c):5]>>[C,c:5][C:3]#[C:2][:1]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_94> into a set of instructions defining the required reactant types and the resulting product pattern.	[:1][C:2]#[CH:3].[I:4][C$(C([CX4,c])([CX4,c])([CX4,c])),C$([CH]([CX4,c])([CX4,c])),C$([CH2]([CX4,c])),C$([CH3]),c$(c):5]>>[C,c:5][C:3]#[C:2][:1]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_95> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(C)([CX4])([CX4])([CX4])),C$([CH](C)([CX4])([CX4])),C$([CH2](C)([CX4])),C$([CH3](C)):1][C:2]#[CH:3].[Br:4][C$(C(=O)([Br])([CX4])),C$([CH](=O)([Br])):5]=[O:6]>>[C:1][C:2]#[C:3][C:5]=[O:6]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_96> into a set of instructions defining the required reactant types and the resulting product pattern.	[C$(C(C)([CX4])([CX4])([CX4])),C$([CH](C)([CX4])([CX4])),C$([CH2](C)([CX4])),C$([CH3](C)):1][C:2]#[CH:3].[I:4][C$(C(=O)([I])([CX4])),C$([CH](=O)([I])):5]=[O:6]>>[C:1][C:2]#[C:3][C:5]=[O:6]	Reaction Type: Synthesis Reactant 1: Requires a generic reactant. Reactant 2: Requires a generic reactant. Product: Forms a generic product.
Deconstruct the reaction template <RNX_97> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH,O-:4]-[C$(C(=O)([OH,O-])([CX4])),C$([CH](=O)([OH,O-])):2]=[O:3]>>[Cl:5][C:2]=[O:3]	Reaction Type: Synthesis Reactant 1: Requires carboxylic acid. Product: Forms a generic product.
Deconstruct the reaction template <RNX_98> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH:2]-[$([CX4]),c:1]>>[Br:3][C,c:1]	Reaction Type: Synthesis Reactant 1: Requires ortho-hydroxyaniline. Product: Forms a generic product.
Deconstruct the reaction template <RNX_99> into a set of instructions defining the required reactant types and the resulting product pattern.	[OH:2]-[$([CX4]),c:1]>>[Cl:3][C,c:1]	Reaction Type: Synthesis Reactant 1: Requires ortho-hydroxyaniline. Product: Forms a generic product.

Deconstruct the reaction template <RNX_0> into a set of instructions defining the required reactant types and the resulting product pattern.

[cH1:1]1:[c:2](-[CH2:7]-[CH2:8]-[NH2:9]):[c:3]:[c:4]:[c:5]:[c:6]:1.[#6:11]-[CH1;R0:10]=[OD1]>>[c:1]12:[c:2](-[CH2:7]-[CH2:8]-[NH1:9]-[C:10]-2(-[#6:11])):[c:3]:[c:4]:[c:5]:[c:6]:1

**Reaction Type:** Synthesis **Reactant 1:** Requires phenethylamine. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_1> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;r6:1](-[NH1;$(N-[#6]):2]):[c;r6:3](-[NH2:4]).[#6:6]-[C;R0:5](=[OD1])-[#8;H1,$(O-[CH3])]>>[c:3]2:[c:1]:[n:2]:[c:5](-[#6:6]):[n:4]2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms imidazole ring.

Deconstruct the reaction template <RNX_2> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;r6:1](-[NH1;$(N-[#6]):2]):[c;r6:3](-[NH2:4]).[#6:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[n:2]:[c:5](-[#6:6]):[n:4]2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms imidazole ring.

Deconstruct the reaction template <RNX_3> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;r6:1](-[SH1:2]):[c;r6:3](-[NH2:4]).[#6:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[s:2]:[c:5](-[#6:6]):[n:4]2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms thiazole ring.

Deconstruct the reaction template <RNX_4> into a set of instructions defining the required reactant types and the resulting product pattern.

[c:1](-[OH1;$(Oc1ccccc1):2]):[c;r6:3](-[NH2:4]).[c:6]-[CH1;R0:5](=[OD1])>>[c:3]2:[c:1]:[o:2]:[c:5](-[c:6]):[n:4]2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_5> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;r6:1](-[OH1:2]):[c;r6:3](-[NH2:4]).[#6:6]-[C;R0:5](=[OD1])-[OH1]>>[c:3]2:[c:1]:[o:2]:[c:5](-[#6:6]):[n:4]2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_6> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:6]-[C;R0:1](=[OD1])-[CH1;R0:5](-[#6:7])-[#17].[NH2:2]-[C:3]=[SD1:4]>>[c:1]2(-[#6:6]):[n:2]:[c:3]:[s:4][c:5]([#6:7]):2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires thioamide. **Product:** Forms thiazole ring.

Deconstruct the reaction template <RNX_7> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:6]-[C;R0:1](=[OD1])-[CH1;R0:5](-[#6:7])-[#35].[NH2:2]-[C:3]=[SD1:4]>>[c:1]2(-[#6:6]):[n:2]:[c:3]:[s:4][c:5]([#6:7]):2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires thioamide. **Product:** Forms thiazole ring.

Deconstruct the reaction template <RNX_8> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:6]-[C;R0:1](=[OD1])-[CH1;R0:5](-[#6:7])-[#53].[NH2:2]-[C:3]=[SD1:4]>>[c:1]2(-[#6:6]):[n:2]:[c:3]:[s:4][c:5]([#6:7]):2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires thioamide. **Product:** Forms thiazole ring.

Deconstruct the reaction template <RNX_9> into a set of instructions defining the required reactant types and the resulting product pattern.

[c:1](-[C;$(C-c1ccccc1):2](=[OD1:3])-[OH1]):[c:4](-[NH2:5]).[N;!H0;!$(N-N);!$(N-C=N);!$(N(-C=O)-C=O):6]-[C;H1,$(C-[#6]):7]=[OD1]>>[c:4]2:[c:1]-[C:2](=[O:3])-[N:6]-[C:7]=[N:5]-2

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_10> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2]>>[C:1]1=[N:2]-N-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_11> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#17]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_12> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#35]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_13> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#53]>>[C:1]1=[N:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_14> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#17]>>[C:1]1=[N:2]-N=N-N-1(-[C:3])

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_15> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#35]>>[C:1]1=[N:2]-N=N-N-1(-[C:3])

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_16> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[C;A;!$(C=O):3]-[#53]>>[C:1]1=[N:2]-N=N-N-1(-[C:3])

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_17> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#17]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_18> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#35]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_19> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#53]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_20> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[OH1]>>[C:1]1=[C:2]-N(-[C:3])-N=N-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-hydroxyaniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_21> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#17]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_22> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#35]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_23> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[#53]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_24> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH1:2].[C;H1,H2;A;!$(C=O):3]-[OH1]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-hydroxyaniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_25> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[#17]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_26> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[#35]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_27> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[#53]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_28> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[CH0;$(C-[#6]):2].[C;H1,H2;A;!$(C=O):3]-[OH1]>>[C:1]1=[C:2]-N=NN(-[C:3])-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-hydroxyaniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_29> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[NH2:3]-[NH1:4]-[CH0;$(C-[#6]);R0:5]=[OD1]>>[N:2]1-[C:1]=[N:3]-[N:4]-[C:5]=1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_30> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH0;$(C-[#6]):1]#[NH0:2].[CH0;$(C-[#6]);R0:5](=[OD1])-[#8;H1,$(O-[CH3]),$(O-[CH2]-[CH3])]>>[N:2]1-[C:1]=N-N-[C:5]=1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_31> into a set of instructions defining the required reactant types and the resulting product pattern.

[c:1](-[C;$(C-c1ccccc1):2](=[OD1:3])-[CH3:4]):[c:5](-[OH1:6]).[C;$(C1-[CH2]-[CH2]-[N,C]-[CH2]-[CH2]-1):7](=[OD1])>>[O:6]1-[c:5]:[c:1]-[C:2](=[OD1:3])-[C:4]-[C:7]-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_32> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;r6:1](-[C;$(C=O):6]-[OH1]):[c;r6:2]-[C;H1,$(C-C):3]=[OD1].[NH2:4]-[NH1;$(N-[#6]);!$(NC=[O,S,N]):5]>>[c:1]1:[c:2]-[C:3]=[N:4]-[N:5]-[C:6]-1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_33> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;$(C-c1ccccc1):1](=[OD1])-[C;D3;$(C-c1ccccc1):2]~[O;D1,H1].[CH1;$(C-c):3]=[OD1]>>[C:1]1-N=[C:3]-[NH1]-[C:2]=1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms imidazole ring.

Deconstruct the reaction template <RNX_34> into a set of instructions defining the required reactant types and the resulting product pattern.

[NH2;$(N-c1ccccc1):1]-[c:2]:[c:3]-[CH1:4]=[OD1].[C;$(C([#6])[#6]):6](=[OD1])-[CH2;$(C([#6])[#6]);!$(C(C=O)C=O):5]>>[N:1]1-[c:2]:[c:3]-[C:4]=[C:5]-[C:6]:1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_35> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:6][C:5]#[#7;D1:4].[#6:1][C:2](=[OD1:3])[OH1]>>[#6:6][c:5]1[n:4][o:3][c:2]([#6:1])n1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_36> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;H1:3]1:[c:4]:[c:5]:[c;H1:6]:[c:7]2:[nH:8]:[c:9]:[c;H1:1]:[c:2]:1:2.O=[C:10]1[#6;H2:11][#6;H2:12][N:13][#6;H2:14][#6;H2:15]1>>[#6;H2:12]3[#6;H1:11]=[C:10]([c:1]1:[c:9]:[n:8]:[c:7]2:[c:6]:[c:5]:[c:4]:[c:3]:[c:2]:1:2)[#6;H2:15][#6;H2:14][N:13]3

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_37> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[OH1;$(Oc1ccccc1):2]>>[C:1][O:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_38> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7H1:2]1~[#7:3]~[#7:4]~[#7:5]~[#6:6]~1>>[C:1][#7:2]1:[#7:3]:[#7:4]:[#7:5]:[#6:6]:1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_39> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7H1:2]1~[#7:3]~[#7:4]~[#7:5]~[#6:6]~1>>[#7H0:2]1:[#7:3]:[#7H0:4]([C:1]):[#7:5]:[#6:6]:1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_40> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7:2]1~[#7:3]~[#7H1:4]~[#7:5]~[#6:6]~1>>[C:1][#7H0:2]1:[#7:3]:[#7H0:4]:[#7:5]:[#6:6]:1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_41> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;H1&$(C([#6])[#6]),H2&$(C[#6]):1][OH1].[#7:2]1~[#7:3]~[#7H1:4]~[#7:5]~[#6:6]~1>>[#7:2]1:[#7:3]:[#7:4]([C:1]):[#7:5]:[#6:6]:1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms tetrazole ring.

Deconstruct the reaction template <RNX_42> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:1][C:2]#[#7;D1].[Cl][#6;$([#6]~[#6]);!$([#6]([Cl,Br,I])[Cl,Br,I]);!$([#6]=O):3]>>[#6:1][C:2](=O)[#6:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_43> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:1][C:2]#[#7;D1].[Br][#6;$([#6]~[#6]);!$([#6]([Cl,Br,I])[Cl,Br,I]);!$([#6]=O):3]>>[#6:1][C:2](=O)[#6:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_44> into a set of instructions defining the required reactant types and the resulting product pattern.

[#6:1][C:2]#[#7;D1].[I][#6;$([#6]~[#6]);!$([#6]([Cl,Br,I])[Cl,Br,I]);!$([#6]=O):3]>>[#6:1][C:2](=O)[#6:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_45> into a set of instructions defining the required reactant types and the resulting product pattern.

[S;$(S(=O)(=O)[C,N]):1][Cl].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[S:1][N+0:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_46> into a set of instructions defining the required reactant types and the resulting product pattern.

[C;$(C([#6])[#6;!$([#6]Br)]):4](=[OD1])[CH;$(C([#6])[#6]):5]Br.[#7;H2:3][C;$(C(=N)(N)[c,#7]):2]=[#7;H1;D1:1]>>[C:4]1=[CH0:5][NH:3][C:2]=[N:1]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_47> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;!$(c1ccccc1);$(c1[n,c]c[n,c]c[n,c]1):1][Cl].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_48> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;!$(c1ccccc1);$(c1[n,c]c[n,c]c[n,c]1):1][F].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_49> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;$(c1c(N(~O)~O)cccc1):1][Cl].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_50> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;$(c1c(N(~O)~O)cccc1):1][F].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_51> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;$(c1ccc(N(~O)~O)cc1):1][F].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_52> into a set of instructions defining the required reactant types and the resulting product pattern.

[c;$(c1ccc(N(~O)~O)cc1):1][Cl].[N;$(NC);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[c,O]);!$(N[C,S]=[S,O,N]):2]>>[c:1][N:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_53> into a set of instructions defining the required reactant types and the resulting product pattern.

[N;$(N-[#6]):3]=[C;$(C=O):1].[N;$(N[#6]);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[O,N]);!$(N[C,S]=[S,O,N]):2]>>[N:3]-[C:1]-[N+0:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_54> into a set of instructions defining the required reactant types and the resulting product pattern.

[N;$(N-[#6]):3]=[C;$(C=S):1].[N;$(N[#6]);!$(N=*);!$([N-]);!$(N#*);!$([ND3]);!$([ND4]);!$(N[O,N]);!$(N[C,S]=[S,O,N]):2]>>[N:3]-[C:1]-[N+0:2]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_55> into a set of instructions defining the required reactant types and the resulting product pattern.

[$(C([CH2,CH3])),CH:10](=[O:11])-[NH+0:9]-[C$(C(N)(C)(C)(C)),C$([CH](N)(C)(C)),C$([CH2](N)(C)):8]-[C$(C(c)(C)(C)(C)),C$([CH](c)(C)(C)),C$([CH2](c)(C)):7]-[c:6]1[cH:1][c:2][c:3][c:4][c:5]1>>[C:10]-1=[N+0:9]-[C:8]-[C:7]-[c:6]2[c:5][c:4][c:3][c:2][c:1]-12

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_56> into a set of instructions defining the required reactant types and the resulting product pattern.

[$(C([CH2,CH3])),CH:10](=[O:11])-[NH+0:9]-[C$([CH](N)(C)(C)),C$([CH2](N)(C)):8]-[C$([C](c)(C)(C)),C$([CH](c)(C)):7]([O$(OC),OH])-[c:6]1[cH:1][c:2][c:3][c:4][c:5]1>>[c:10]-1[n:9][c:8][c:7][c:6]2[c:5][c:4][c:3][c:2][c:1]-12

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_57> into a set of instructions defining the required reactant types and the resulting product pattern.

[NH3+,NH2]-[C$(C(N)(C)(C)(C)),C$([CH](N)(C)(C)),C$([CH2](N)(C)):8]-[C$(C(c)(C)(C)(C)),C$([CH](c)(C)(C)),C$([CH2](c)(C)):7]-[c:6]1[c:1][c:2][nH:3][cH:5]1.[CH:10](-[CX4:12])=[O:11]>>[c,C:12]-[CH:10]-1-[N]-[C:8]-[C:7]-[c:6]2[c:1][c:2][nH:3][c:5]-12

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_58> into a set of instructions defining the required reactant types and the resulting product pattern.

[NH2,NH3+1:8]-[c:5]1[cH:4][c:3][c:2][c:1][c:6]1.[Br:18][C$([CH2](C)(Br)),C$([CH](C)(C)(Br)):17]-[C:15](=[O:16])-[c:10]1[c:11][c:12][c:13][c:14][c:9]1>>[c:13]1[c:12][c:11][c:10]([c:9][c:14]1)-[c:15]1[c:17][c:4]2[c:3][c:2][c:1][c:6][c:5]2[nH+0:8]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_59> into a set of instructions defining the required reactant types and the resulting product pattern.

[Cl:1][CH2:2]-[C$([CH](C)),C$(C(C)(C)):3]=[O:4].[OH:12]-[c:11]1[c:6][c:7][c:8][c:9][c:10]1-[CH:13]=[O:14]>>[C:3](=[O:4])-[c:2]1[c:13][c:10]2[c:9][c:8][c:7][c:6][c:11]2[o:12]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_60> into a set of instructions defining the required reactant types and the resulting product pattern.

[NH2,NH3+]-[C$([CX4](N)([c,C])([c,C])([c,C])),C$([CH](N)([c,C])([c,C])),C$([CH2](N)([c,C])),C$([CH3](N)):2].[NH2:12]-[c:7]1[c:6][c:5][c:4][c:3][c:8]1-[C:9](-[OH,O-:11])=[O:10]>>[C:2]-[n+0]-1[c:13][n:12][c:7]2[c:6][c:5][c:4][c:3][c:8]2[c:9]-1=[O:10]

**Reaction Type:** Synthesis **Reactant 1:** Requires phenethylamine. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_61> into a set of instructions defining the required reactant types and the resulting product pattern.

[N$([NH2]([CX4])),N$([NH3+1]([CX4])):1].[O:5]-[C$([CH]([CX4])(C)(O)),C$([CH2]([CX4])(O)):3][C$(C([CX4])(=O)([CX4])),C$([CH]([CX4])(=O)):4]=[O:6]>[O:15]=[C:9]-1-[CH2:10]-[CH2:11]-[CH2:12]-[CH2:13]-[CH2:14]-1>[C:4]1[C:3][N+0:1][C:10]2-[C:11]-[C:12]-[C:13]-[C:14]-[C:9]12

**Reaction Type:** Synthesis **Reactant 1:** Requires phenethylamine. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_62> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(=O)([CX4])([CX4])),C$([CH](=O)([CX4])):2](=[O:6])-[C$([CH]([CX4])),C$([CH2]):3]-[C$(C(=O)([CX4])([CX4])),C$([CH](=O)([CX4])):4]=[O:7].[NH2:8]-[C:9](=[O:10])-[CH2:11][C:12]#[N:13]>>[OH:10]-[c:9]1[n:8][c:4][c:3][c:2][c:11]1[C:12]#[N:13]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_63> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(#C)([CX4])):2]#[C$(C(#C)([CX4])):1].[N$(N(~N)([CX4])):5]=[N+]=[N-]>>[c:2]1[c:1][n:5][n][n]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_64> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(=C)([CX4])):2]=[C$(C(=C)([CX4])):1].[N$(N(~N)([CX4&D1])):5]~[N]~[N]>>[C:2]1[C:1][N:5][N]=[N]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_65> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):1]=[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):2].[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):3]=[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):4]-[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):5]=[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):6]>>[C:1]1[C:2][C:3][C:4]=[C:5][C:6]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_66> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(#C)([CX4,OX2,NX3])),C$([CH](#C)):1]#[C$(C(#C)([CX4,OX2,NX3])),C$([CH](#C)):2].[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):3]=[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):4]-[C$([C](=C)(C)([CX4,OX2,NX3])),C$([CH](=C)(C)):5]=[C$(C(=C)([CX4,OX2,NX3])([CX4,OX2,NX3])),C$([CH](=C)([CX4,OX2,NX3])),C$([CH2](=C)):6]>>[C:1]1=[C:2][C:3][C:4]=[C:5][C:6]1

**Reaction Type:** Synthesis **Reactant 1:** Requires alkyne. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_67> into a set of instructions defining the required reactant types and the resulting product pattern.

[CH:7](=[O:8])-[c:1]1[c:2][c:3][c:4][c:5][c:6]1.[O:24]=[C:23](-[C:22](=[O:25])-[c:15]1[c:10][c:11][c:12][c:13][c:14]1)-[c:20]1[c:21][c:16][c:17][c:18][c:19]1>[NH4].[O-]C(=O)C>[nH:27]-1[c:7]([n:26][c:23]([c:22]-1[c:15]1[c:10][c:11][c:12][c:13][c:14]1)-[c:20]1[c:21][c:16][c:17][c:18][c:19]1)-[c:1]1[c:2][c:3][c:4][c:5][c:6]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms imidazole ring.

Deconstruct the reaction template <RNX_68> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH:7]-[c:6]1[cH:1][c:2][c:3][c:4][c:5]1.[O$(O(C)([CX4])):12]-[C:11](=[O:15])-[C$([CH](C)(C)([CX4])),C$([CH2](C)(C)):10]-[C:8]=[O:16]>>[C:8]-1=[C:10]-[C:11](=[O:15])-[O]-[C:6]2[C:5][C:4][C:3][C:2][C:1]-12

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_69> into a set of instructions defining the required reactant types and the resulting product pattern.

[O$(O(C)([CX4])):8][C:7](=[O:9])[CH:6][C:5][C:4][C:3][C:2]([O$(O(C)([CX4])):10])=[O:1]>>[O:8][C:7](=[O:9])[C:6]1[C:5][C:4][C:3][C:2]1=[O:1]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_70> into a set of instructions defining the required reactant types and the resulting product pattern.

[O$(O(C)([CX4])):8][C:7](=[O:9])[CH:6][C:5][C:11][C:4][C:3][C:2]([O$(O(C)([CX4])):10])=[O:1]>>[O:8][C:7](=[O:9])[C:6]1[C:5][C:11][C:4][C:3][C:2]1=[O:1]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_71> into a set of instructions defining the required reactant types and the resulting product pattern.

[Cl:9][C:7](=[O:8])-[c:3]1[c:2][c:1][c:6][c:5][c:4]1.[C$([CH2](C)([CX4])),C$([CH3](C)):18]-[C:16](=[O:17])-[c:14]1[c:13][c:12][c:11][c:10][c:15]1-[OH:19]>>[O:17]=[C:16]-1-[C:18]=[C:7](-[O:8]-[c:15]2[c:10][c:11][c:12][c:13][c:14]-12)-[c:3]1[c:2][c:1][c:6][c:5][c:4]1

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_72> into a set of instructions defining the required reactant types and the resulting product pattern.

[Cl:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[O$([OH]([CX4,c])),O$([OH]([CX4,c])([CX4,c])),S$([SH]([CX4,c])),S$([SH]([CX4,c])([CX4,c])):6]>>[*:6]-[C:2]=[O:4]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_73> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[O$([OH]([CX4,c])),O$([OH]([CX4,c])([CX4,c])),S$([SH]([CX4,c])),S$([SH]([CX4,c])([CX4,c])):6]>>[*:6]-[C:2]=[O:4]

**Reaction Type:** Synthesis **Reactant 1:** Requires carboxylic acid. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_74> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH]-[C$(C(=O)(O)([CX4,c])):2]=[O:3].[OH:8]-[C$([CH](O)([CX4,c])([CX4,c])),C$([CH2](O)([CX4,c])),C$([CH3](O)):6]>>[C:6][O]-[C:2]=[O:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_75> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([CH](=C)([CX4])),C$([CH2](=C)):2]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):3].[Br:7][C$([CX4]([Br])),c$([c]([Br])):4]>>[C,c:4][C:2]=[C:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_76> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([CH](=C)([CX4])),C$([CH2](=C)):2]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):3].[I:7][C$([CX4]([I])),c$([c]([I])):4]>>[C,c:4][C:2]=[C:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_77> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[N$([NH2,NH3+1]([CX4,c])),N$([NH]([CX4,c])([CX4,c])):6]>>[N+0:6]-[C:2]=[O:4]

**Reaction Type:** Synthesis **Reactant 1:** Requires carboxylic acid. **Reactant 2:** Requires phenethylamine. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_78> into a set of instructions defining the required reactant types and the resulting product pattern.

[Cl:3][C$(C(=O)([CX4,c])),C$([CH](=O)):2]=[O:4].[N$([NH2,NH3+1]([CX4,c])),N$([NH]([CX4,c])([CX4,c])):6]>>[N+0:6]-[C:2]=[O:4]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires phenethylamine. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_79> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):1]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):2].[SH:4]-[CX4:5][Br]>>[C:1]-[C:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_80> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):1]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):2].[SH:4]-[CX4:5][Cl]>>[C:1]-[C:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_81> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):1]=[C$(C(=C)([CX4])([CX4])),C$([CH](=C)([CX4])),C$([CH2](=C)):2].[SH:4]-[CX4:5][I]>>[C:1]-[C:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_82> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[OH:6].[SH:4]-[CX4:5][Br]>>[CH2:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires carboxylic acid. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_83> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[OH:6].[SH:4]-[CX4:5][Cl]>>[CH2:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires carboxylic acid. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_84> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[OH:6].[SH:4]-[CX4:5][I]>>[CH2:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires carboxylic acid. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_85> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[Cl:6].[SH:4]-[CX4:5][Br]>>[CH2:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_86> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[Cl:6].[SH:4]-[CX4:5][Cl]>>[CH2:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_87> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$([C](=O)([CX4])),C$([CH](=O)):2](=[O:1])[Cl:6].[SH:4]-[CX4:5][I]>>[CH2:2]-[S:4][C:5]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_88> into a set of instructions defining the required reactant types and the resulting product pattern.

[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([Cl])([CX4,c])),C$([CH]([Cl])(=O)):3](=[O:6])[Cl:5]>>[C:2]-[C:3]=[O:6]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_89> into a set of instructions defining the required reactant types and the resulting product pattern.

[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([OH])([CX4,c])),C$([CH]([OH])(=O)):3](=[O:6])[Cl:5]>>[C:2]-[C:3]=[O:6]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_90> into a set of instructions defining the required reactant types and the resulting product pattern.

[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([Cl])([CX4,c])),C$([CH]([Cl])(=O)):3](=[O:6])[OH:5]>>[C:2]-[C:3]=[O:6]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_91> into a set of instructions defining the required reactant types and the resulting product pattern.

[I:1][C$(C(I)([CX4,c])([CX4,c])([CX4,c])),C$([CH](I)([CX4,c])([CX4,c])),C$([CH2](I)([CX4,c])),C$([CH3](I)):2].[C$(C(=O)([OH])([CX4,c])),C$([CH]([OH])(=O)):3](=[O:6])[OH:5]>>[C:2]-[C:3]=[O:6]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires carboxylic acid. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_92> into a set of instructions defining the required reactant types and the resulting product pattern.

[Cl:5][S$(S(=O)(=O)(Cl)([CX4])):2](=[O:3])=[O:4].[NH2+0,NH3+:6]-[C$(C(N)([CX4,c])([CX4,c])([CX4,c])),C$([CH](N)([CX4,c])([CX4,c])),C$([CH2](N)([CX4,c])),C$([CH3](N)),c$(c(N)):7]>>[C,c:7]-[NH+0:6][S:2](=[O:4])=[O:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires ortho-amino-N-substituted-aniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_93> into a set of instructions defining the required reactant types and the resulting product pattern.

[*:1][C:2]#[CH:3].[Br:4][C$(C([CX4,c])([CX4,c])([CX4,c])),C$([CH]([CX4,c])([CX4,c])),C$([CH2]([CX4,c])),C$([CH3]),c$(c):5]>>[C,c:5][C:3]#[C:2][*:1]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_94> into a set of instructions defining the required reactant types and the resulting product pattern.

[*:1][C:2]#[CH:3].[I:4][C$(C([CX4,c])([CX4,c])([CX4,c])),C$([CH]([CX4,c])([CX4,c])),C$([CH2]([CX4,c])),C$([CH3]),c$(c):5]>>[C,c:5][C:3]#[C:2][*:1]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_95> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(C)([CX4])([CX4])([CX4])),C$([CH](C)([CX4])([CX4])),C$([CH2](C)([CX4])),C$([CH3](C)):1][C:2]#[CH:3].[Br:4][C$(C(=O)([Br])([CX4])),C$([CH](=O)([Br])):5]=[O:6]>>[C:1][C:2]#[C:3][C:5]=[O:6]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_96> into a set of instructions defining the required reactant types and the resulting product pattern.

[C$(C(C)([CX4])([CX4])([CX4])),C$([CH](C)([CX4])([CX4])),C$([CH2](C)([CX4])),C$([CH3](C)):1][C:2]#[CH:3].[I:4][C$(C(=O)([I])([CX4])),C$([CH](=O)([I])):5]=[O:6]>>[C:1][C:2]#[C:3][C:5]=[O:6]

**Reaction Type:** Synthesis **Reactant 1:** Requires a generic reactant. **Reactant 2:** Requires a generic reactant. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_97> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH,O-:4]-[C$(C(=O)([OH,O-])([CX4])),C$([CH](=O)([OH,O-])):2]=[O:3]>>[Cl:5][C:2]=[O:3]

**Reaction Type:** Synthesis **Reactant 1:** Requires carboxylic acid. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_98> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH:2]-[$([CX4]),c:1]>>[Br:3][C,c:1]

**Reaction Type:** Synthesis **Reactant 1:** Requires ortho-hydroxyaniline. **Product:** Forms a generic product.

Deconstruct the reaction template <RNX_99> into a set of instructions defining the required reactant types and the resulting product pattern.

[OH:2]-[$([CX4]),c:1]>>[Cl:3][C,c:1]

**Reaction Type:** Synthesis **Reactant 1:** Requires ortho-hydroxyaniline. **Product:** Forms a generic product.