clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-53.9
401
scaffold
stringlengths
0
100
CNc1ccc(C(=O)NCC2CCCN2C(=O)Cn2cccn2)c(Cl)c1
CP002715509468
-21
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC(C)c1ccc(C(=O)NC[C@@]2(C)CCCN2C(=O)Cn2cc(C#N)cn2)cc1
CP000173670597
-20.87
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccc(C(=O)NC[C@@]2(C)CCCN2C(=O)Cn2nccc2N)c(C)c1
CP001765079100
-20.78
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1cc(C)ccc1C(=O)NCC1CCCN1C(=O)Cn1nc(C)c(C)c1C
CP000345488391
-20.63
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1cc(C(=O)N(C)CC2CCCN2C(=O)Cn2cccn2)ccc1F
CP001721760519
-20.32
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC1(C)CC(CNC(=O)c2ccccc2CO)N(C(=O)Cn2ccc(N)n2)C1
CP000607334401
-20.17
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC1(C)CC(CNC(=O)c2ccccc2Cl)N(C(=O)C(F)n2cccn2)C1
CP001753641806
-20.04
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
C[C@]1(CNC(=O)c2ccc(C(F)(F)F)cc2)CCCN1C(=O)Cn1cccn1
CP000763740858
-20.01
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1cc(C(=O)NC[C@]2(C)CCCN2C(=O)Cn2cc(N)cn2)ccc1C
CP000584025549
-19.98
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
C[C@@]1(CNC(=O)c2ccccc2CO)CCCN1C(=O)Cn1ccc(N)n1
CP001689810167
-19.97
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cnn(CC(=O)N2CCCC2CNC(=O)c2c(F)ccc(C)c2N)c1
CP001788797735
-19.95
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccc(F)cc1Cl
CP003208687069
-19.92
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cc(F)cc(C(=O)NC[C@@]2(C)CCCN2C(=O)Cn2cc(N)cn2)c1
CP001765658681
-19.9
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccc(F)c(C(=O)NC[C@]2(C)CCCN2C(=O)Cn2cc(C#N)cn2)c1
CP000584218971
-19.9
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
N#Cc1cnn(CC(=O)N2CCCC2CNC(=O)c2ccccc2Cl)c1N
CP002073896247
-19.79
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cc(C(=O)NCC2CCCN2C(=O)Cn2nccc2C)ccc1F
CP002883417242
-19.67
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1c(F)cccc1C(=O)NC(C)(C)C1CCCN1C(=O)Cn1cc(C#N)cn1
CP000075687438
-19.38
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
C=CCCCc1ccc(C(=O)N(C)CC2CCCN2C(=O)Cn2cccn2)cc1
CP000076703032
-19.33
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC(C(=O)N1CCCC1CN(C)C(=O)c1cc(N)cc(N)c1)n1cccn1
CP001976973931
-19.29
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cccc(C(=O)NCC2CCCN2C(=O)Cn2ccc(N)n2)c1C
CP002882731743
-19.18
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC(C(=O)N1CCCC1CNC(=O)c1cc(Cl)c(N)cc1F)n1cccn1
CP001788793534
-19.12
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccnn1CC(=O)N1CCC[C@@]1(C)CNC(=O)c1cccc(C#CCO)c1
CP000056173475
-18.9
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cnn(C(C)C(=O)N2CCCC2CN(C)C(=O)c2ccc(F)cc2C)c1
CP000733644972
-18.69
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cc(N)n(CC(=O)N2CCCC2(C)CNC(=O)c2ccccc2Cl)n1
CP001651627994
-18.66
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccc(C(=O)N(C)CC2CCCN2C(=O)Cn2cc(C)cn2)cc1
CP002573697290
-18.37
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1ccccc1C(=O)NCC1(C)CCCN1C(=O)Cn1ccc(C)n1
CP001651629355
-18.37
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccnn1CC(=O)N1CCCC1(C)CNC(=O)c1cccc(F)c1
CP002582771553
-18.1
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CNC(=O)c1cccc(C(=O)NCC2CCCN2C(=O)C(C)(C)n2cccn2)c1
CP000345359732
-17.64
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccn(CC(=O)N2CCCC2CNC(=O)c2ccc(N)c(C)c2)n1
CP002715680094
-17.61
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Nc1ccnn1CC(=O)N1CC(F)(F)CC1CNC(=O)c1ccc(CO)cc1
CP000590711253
-17.59
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1cccc(C(=O)NCC2CCCN2C(=O)Cn2nccc2N)c1OC
CP001064799005
-17.5
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccn(CC(=O)N2CCC[C@]2(C)CNC(=O)c2ccc(CO)c(F)c2)n1
CP000764734098
-16.96
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cnn(CC(=O)N2CCCC2CN(C)C(=O)c2cccc(F)c2Cl)c1
CP001721772469
-16.86
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COC(=O)c1cccc(C(=O)NCC2CCCN2C(=O)C(F)n2cccn2)c1
CP000870323759
-16.79
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccc(C(=O)NCC2C(C)CCN2C(=O)Cn2ccc(C)n2)c(Cl)c1
CP001757940129
-16.41
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
C[C@@]1(CNC(=O)c2cccc(CO)c2)CCCN1C(=O)Cn1cc(N)cn1
CP001690065942
-16.14
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1cc(O)c(Cl)cc1C(=O)NCC1CCCN1C(=O)Cn1nccc1C
CP001789038851
-15.98
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CCOc1ccccc1C(=O)NC[C@@]1(C)CCCN1C(=O)Cn1nccc1C
CP000763751577
-15.89
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccn(CC(=O)N2CCCC2CN(C)C(=O)c2ccc(N)cc2C)n1
CP001977231892
-15.46
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1cccc(F)c1C(=O)NC[C@]1(C)CCCN1C(=O)Cn1cc(C#N)cn1
CP000056083827
-14.73
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1cccc(O)c1C(=O)N(C)CC1CCCN1C(=O)Cn1cc(C)cn1
CP000889542427
-13.3
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COc1ccccc1C(=O)NCC1(C)CCCN1C(=O)Cn1cc(C)cn1
CP001651629139
-13.18
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccn(CC(=O)N2CCCC2CN(C)C(=O)c2cccc(F)c2)n1
CP002573499380
-12.98
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccc(F)c(O)c1
CP003291457945
-12.9
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC1(C)CC(CNC(=O)c2c(F)cccc2F)N(C(=O)Cn2ccc(N)n2)C1
CP000606693723
-12.81
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC(C)c1ccccc1C(=O)N(C)CC1CCCN1C(=O)C(C)n1cccn1
CP000734143416
-12.63
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
Cc1ccn(CC(=O)N2CCCC2CN(C)C(=O)c2cc(C)c(N)cc2F)n1
CP000889821457
-2.52
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
COCc1ccc(C(=O)NC(C)(C)C2CCCN2C(=O)Cn2cc(C)cn2)cc1
CP000075530082
null
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CC1CCN(C(=O)C(C)n2cc(Cl)cn2)C1CNC(=O)c1ccc(F)cc1
CP001757100154
null
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CSc1ccc(C(=O)NCC2C(C)CCN2C(=O)Cn2cc(C#N)cn2)cc1
CP000756336349
null
O=C(NCC1CCCN1C(=O)Cn1cccn1)c1ccccc1
CCS(=O)(=O)Cc1ccc(NC(=O)Nc2cnn(-c3ccccn3)c2)cc1
CP000521139292
-34.4
O=C(Nc1ccccc1)Nc1cnn(-c2ccccn2)c1
CCOCc1ccc(NC(=O)Nc2cnn(-c3ncccc3F)c2)cc1
CP000884583331
-33.78
O=C(Nc1ccccc1)Nc1cnn(-c2ccccn2)c1
COCCOCc1cccc(NC(=O)Nc2cnn(-c3ncccc3F)c2)c1
CP000406575701
-33.52
O=C(Nc1ccccc1)Nc1cnn(-c2ccccn2)c1
CCC(CC1CCCC1)C(=O)N[C@@H]1CCCN(C(=O)CN2CCN(C)CC2)C1
CP001141191966
-18.33
O=C(CCC1CCCC1)N[C@@H]1CCCN(C(=O)CN2CCNCC2)C1
C=C1CC1C(=O)N1CC2CCC(NC(=O)c3cccn(O)c3=O)C2C1
CP003313375032
-10.69
C=C1CC1C(=O)N1CC2CCC(NC(=O)c3ccc[nH]c3=O)C2C1
CCCN(CCNC(=O)c1cnc2c(c1)c(C)nn2C)c1nccnc1C#N
CP000505716645
-26.45
O=C(NCCNc1cnccn1)c1cnc2[nH]ncc2c1
Nc1cccc(-n2cc(CNC(=O)c3ccnc(OC4CCCCC4)c3)nn2)c1
CP000328019344
-26.65
O=C(NCc1cn(-c2ccccc2)nn1)c1ccnc(OC2CCCCC2)c1
O=C(CCF)NC1CCCCC12CCCN(C(=O)Cn1cc(CO)nn1)C2
CP001860480786
-8.82
O=C(Cn1ccnn1)N1CCCC2(CCCCC2)C1
N=C(N)SCC(=O)NC1CCCCC12CCCN(C(=O)Cn1ccnn1)C2
CP001860468911
-7.89
O=C(Cn1ccnn1)N1CCCC2(CCCCC2)C1
CO[C@H](C)C(=O)NCC1CC2(CCC2)CN1C(=O)C1(C)COC(=O)OC1
CP002766681047
null
O=C1OCC(C(=O)N2CCC3(CCC3)C2)CO1
NC(=O)c1cccc(CN2CCC3(CCN(C(=O)CCc4cscn4)C3)C2)c1
CP000546393229
-30.59
O=C(CCc1cscn1)N1CCC2(CCN(Cc3ccccc3)C2)C1
CC1(C)C(C(=O)NC2CCCC23CN(c2cc(C4CC4)ncn2)C3)C1(C)C
CP001460250345
null
O=C(NC1CCCC12CN(c1cc(C3CC3)ncn1)C2)C1CC1
NC(=O)N1CC(O)CC1C(=O)NC1(CO)CN(C(=O)Cc2ccc(=O)[nH]c2)C1
CP000846732831
-10.63
O=C(NC1CN(C(=O)Cc2ccc(=O)[nH]c2)C1)C1CCCN1
Cc1nc(Cl)cc(N2CCC(CO)C(NC(=O)CN3CC4CC4C3)CC2)n1
CP001461532129
-27.73
O=C(CN1CC2CC2C1)NC1CCCN(c2ccncn2)CC1
O=C(CN1CC2CC2C1)NC1CCCN(c2cc(Cl)ncn2)CC1
CP002918898110
-26.57
O=C(CN1CC2CC2C1)NC1CCCN(c2ccncn2)CC1
O=C(CN1CC2CC2C1)NC1CCCN(c2ncnc(Cl)c2CO)CC1
CP001916969501
-22.51
O=C(CN1CC2CC2C1)NC1CCCN(c2ccncn2)CC1
Cc1cncnc1N1CCC(CO)C(NC(=O)CN2CC3CC3C2)CC1
CP002224566083
-22.19
O=C(CN1CC2CC2C1)NC1CCCN(c2ccncn2)CC1
O=C(Cc1c[nH]c2nccc(Cl)c12)NCC1(CO)CC2(CC(F)(F)C2)C1
CP001053355555
-16.18
O=C(Cc1c[nH]c2ncccc12)NCC1CC2(CCC2)C1
Cc1nc(O)ccc1C(=O)N(C)C(CNC(=O)C12CCOC(C)(C1)C2)C1CC1
CP000776781385
-19.8
O=C(NC(CNC(=O)C12CCOC(C1)C2)C1CC1)c1cccnc1
CNc1ncccc1C(=O)NC(CNC(=O)C12CCOC(C)(C1)C2)C1CC1
CP002241296175
null
O=C(NC(CNC(=O)C12CCOC(C1)C2)C1CC1)c1cccnc1
CN(c1ncnc(C(C)(C)C)n1)C1CCN(C(=O)c2ccc3nc[nH]c3n2)CC1
CP000276885049
-31.98
O=C(c1ccc2nc[nH]c2n1)N1CCC(Nc2ncncn2)CC1
Cc1cccc(NC(=O)CN2CC[C@H](NC(=O)c3cc4ccsc4[nH]3)C2)c1C
CP000542930087
-32.37
O=C(CN1CC[C@H](NC(=O)c2cc3ccsc3[nH]2)C1)Nc1ccccc1
CN(Cc1cc(C#N)cs1)C(=O)C(=O)NCc1ccnc(N2CCCC2)c1
CP001287782077
-23.1
O=C(NCc1ccnc(N2CCCC2)c1)C(=O)NCc1cccs1
O=C(COCc1ccccn1)N1CCC(CCNC(=O)C2(n3cncn3)CC2)C1
CP000224602552
-22.42
O=C(COCc1ccccn1)N1CCC(CCNC(=O)C2(n3cncn3)CC2)C1
CC(C)n1ncc2c(C(=O)N3CCCCC(CN)C3)cc(-c3cccs3)nc21
CP000404668196
null
O=C(c1cc(-c2cccs2)nc2[nH]ncc12)N1CCCCCC1
C=C(F)C1(CC(=O)NCCCC(C)NC(=O)CCc2nccs2)CCC1
CP002521870230
-18.77
O=C(CCc1nccs1)NCCCCNC(=O)CC1CCC1
Cc1noc2ncnc(N(CCO)C3CCN(C(=O)[C@@H]4CCCN4C)CC3)c12
CP000437396106
-17.49
O=C([C@@H]1CCCN1)N1CCC(Nc2ncnc3oncc23)CC1
CCC1(C)CC(C(=O)N2CC(C(C)NC(=O)CN3Cc4ccccc4C3=O)C2)C1
CP000257262905
-22.15
O=C(CN1Cc2ccccc2C1=O)NCC1CN(C(=O)C2CCC2)C1
CC1CCN(C(=O)[C@@H]2CNC(=O)N2)CC1CNC(=O)C(C1CC1)C1CC1
CP002350872188
-16.4
O=C1NC[C@@H](C(=O)N2CCCC(CNC(=O)C(C3CC3)C3CC3)C2)N1
O=C(N[C@H]1[C@@H]2CN(C(=O)C=Cc3ccccn3)C[C@@H]21)c1ccoc1Cl
CP003311599036
-24.45
O=C(N[C@H]1[C@@H]2CN(C(=O)C=Cc3ccccn3)C[C@@H]21)c1ccoc1
Cn1cc(CC(=O)N2CCCC2(C)CNC(=O)C(F)CC2CC2)c2ccccc21
CP000120849864
-25.96
O=C(CCC1CC1)NCC1CCCN1C(=O)Cc1c[nH]c2ccccc12
Cn1cc(CC(=O)N2CCC[C@]2(C)CNC(=O)CCC2(C)CC2)c2ccccc21
CP000173833058
-24.36
O=C(CCC1CC1)NCC1CCCN1C(=O)Cc1c[nH]c2ccccc12
O=C(CCC1CC1)NCC1CCCN1C(=O)Cc1c[nH]c2cc(F)ccc12
CP002073748912
-16.6
O=C(CCC1CC1)NCC1CCCN1C(=O)Cc1c[nH]c2ccccc12
Cn1ncc(C2CCC2)c1C(=O)NC1CCN(C(=O)C(F)Cc2ccccc2)C1
CP000365004729
-22.52
O=C(NC1CCN(C(=O)CCc2ccccc2)C1)c1[nH]ncc1C1CCC1
N#Cc1cc(C(=O)NCCCOCCNC(=O)C2CCc3nccn3C2)co1
CP000774153883
-24.14
O=C(NCCCOCCNC(=O)C1CCc2nccn2C1)c1ccoc1
Cc1n[nH]cc1CNC(=O)N1CCN(c2nc(Cl)c(C#N)n2C)CC1
CP001565888479
-34.85
O=C(NCc1cn[nH]c1)N1CCN(c2ncc[nH]2)CC1
CC(C)Cn1cc(CCCNC(=O)c2cccc3cc(F)ccc23)nn1
CP001268145424
-34.19
O=C(NCCCc1c[nH]nn1)c1cccc2ccccc12
CC1(C)CC=C(C(=O)N2C[C@@H]3CN(C(=O)c4noc5ccccc45)C[C@@H]3C2)CC1
CP000266012028
-22.48
O=C(C1=CCCCC1)N1C[C@@H]2CN(C(=O)c3noc4ccccc34)C[C@@H]2C1
COCCN(CCNC(=O)CN1Cc2ccccc2C1)C(=O)[C@H]1CCC(=O)N1
CP000580699871
-20.42
O=C(CN1Cc2ccccc2C1)NCCNC(=O)[C@H]1CCC(=O)N1
Cc1ncsc1C(=O)NCC1CCCCN1C(=O)C1(C(F)F)CCCC1
CP002973533483
-24.07
O=C(NCC1CCCCN1C(=O)C1CCCC1)c1cncs1
CC(C)c1ncc(C(=O)NCC2C(C)CCCN2C(=O)C2(F)CCCC2)s1
CP002088235301
-23.86
O=C(NCC1CCCCN1C(=O)C1CCCC1)c1cncs1
Cc1ncc(C(=O)NCC2CCCCN2C(=O)C2(C(F)F)CCCC2)s1
CP002973533490
-17.98
O=C(NCC1CCCCN1C(=O)C1CCCC1)c1cncs1
Cc1nc(C)c(C(=O)NCC2CCCCN2C(=O)C2(C)CCC(C)C2)s1
CP002973624712
null
O=C(NCC1CCCCN1C(=O)C1CCCC1)c1cncs1
CCC1C(C(=O)N2CCN(CC3CC3)CC2)CCN1C(=O)OC(C)(C)C
CP001044415484
-16.43
O=C(C1CCNC1)N1CCN(CC2CC2)CC1
CCN1CCN(CC(=O)NCc2cn(Cc3nn(C)cc3C)nn2)CC1
CP001272458773
-21.48
O=C(CN1CCNCC1)NCc1cn(Cc2cc[nH]n2)nn1
COc1ccnc(C(=O)NCC2(C3CC3)CCN(C(=O)C3CC=CC3)C2)c1
CP001825044203
-25.97
O=C(NCC1(C2CC2)CCN(C(=O)C2CC=CC2)C1)c1ccccn1
COc1ccc(C=CC(=O)N2CCC3(CCN(C(=O)c4oncc4C)C3)C2)cc1
CP000252049736
-32.37
O=C(C=Cc1ccccc1)N1CCC2(CCN(C(=O)c3ccno3)C2)C1
O=C(C=Cc1cccc(CO)c1)N1CCC2(CCN(C(=O)c3ccno3)C2)C1
CP000867790289
-27.24
O=C(C=Cc1ccccc1)N1CCC2(CCN(C(=O)c3ccno3)C2)C1
CCC(C(=O)NCC1(NC(=O)c2cnsn2)CCCC1)C1CCOCC1
CP002619075352
null
O=C(CC1CCOCC1)NCC1(NC(=O)c2cnsn2)CCCC1
CC1(CNc2ncc3c(n2)COC3)CCN(C(=O)C2(C)CC=CC2)C1
CP002399161654
-25.92
O=C(C1CC=CC1)N1CCC(CNc2ncc3c(n2)COC3)C1